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UAF1 is a subunit of multiple deubiquitinating enzyme complexes. Paper-13617072.
Furthermore, we demonstrate the purification of a ternary USP12 x UAF1 x WDR20 complex. Paper-14695432.
Peak latency and peak to peak amplitude of P80, P100, and P200 waves were measured. Paper-13715598.
WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex. Paper-14695432.
We identified WDR20, a WD40-repeat containing protein, as a common binding partner of UAF1, USP12, and USP46. Paper-14695432.
Mean amplitude of P80 and P100 waves increased significantly after PTNS while it did not vary after sham stimulation. Paper-13715598.
The UAF1 ( Usp1-associated factor 1) protein binds and stimulates three deubiquitinating enzymes: USP1, USP12, and USP46. Paper-14695432.
UAF1 binding increases the catalytic turnover (kcat) but does not increase the affinity of the USP1 enzyme for the substrate (KM). Paper-12645118.
RESULTS: Mean latency of P80, P100, and P200 and mean amplitude of P200 did not show any significant change after both stimulation. Paper-13715598.
CONCLUSION: The P80 and P100 amplitude increase might reflect long-term modifications in synaptic efficiency through the somatosensory pathway. Paper-13715598.
Interestingly, and consistent with the binding assays, WDR20 stimulated the enzymatic activity of USP12 x UAF1, but not of USP1 x UAF1. Paper-14695432.
We provide a model in which WDR20 serves as a stimulatory subunit for preserving and regulating the activity of the subset of the UAF1 x USP complexes. Paper-14695432.
Moreover, we show that DNA damage results in an immediate shutoff of transcription of the USP1 gene, leading to a rapid decline in the USP1/ UAF1 protein complex. Paper-12645118.
A protocol is described here to study the molecular association between p80 TNFR-2 and TRAF2 fusion proteins containing CFP and YFP using flow cytometric FRET measurement. Paper-10318711.
Although the USP1 x UAF1 complex is required for regulation of the Fanconi anemia (FA) DNA repair pathway, less is known about the USP12 x UAF1 and the USP46 x UAF1 complexes. Paper-14695432.
Here we report the purification of a USP1 multisubunit protein complex from HeLa cells containing stoichiometric amounts of a WD40 repeat-containing protein, USP1 associated factor 1 ( UAF1). Paper-12645118.
In vitro reconstitution of USP1 deubiquitinating enzyme activity, using either ubiquitin-7-amido-4-methylcoumarin (Ub-AMC) or purified monoubiquitinated FANCD2 protein as substrates, demonstrates that UAF1 functions as an activator of USP1. Paper-12645118.
We recently reported that the USP1 deubiquitinating enzyme, which regulates the Fanconi anemia pathway by deubiquitinating the central player of the pathway, FANCD2, is activated by the WD40-repeat containing UAF1 protein through formation of a stable USP1/ UAF1 protein complex. Paper-13617072.
These synonyms are used for gene WDR48 (WD repeat domain 48): WD repeat endosomal protein, WD repeat-containing protein 48, USP1-associated factor 1, UAF1, P80, p80, KIAA1449, DKFZp686G1794.
These accession numbers are used for gene WDR48: Q658Y1 (UNIPROT__AC), Q63HJ2 (UNIPROT__AC), AK302307 (NCBI_GENBANK__AC), AK025513 (NCBI_GENBANK__AC).
WDR48 is a homologue of WDR48 (WD repeat domain 48) from Pan troglodytes.
WDR48 is a homologue of WDR48 (WD repeat domain 48) from Canis lupus familiaris.
WDR48 is a homologue of WDR48 (WD repeat domain 48) from Bos taurus.
WDR48 is a homologue of WDR48 (WD repeat domain 48) from Gallus gallus.
WDR48 is a homologue of Wdr48 (WD repeat domain 48) from Mus musculus.
WDR48 is a homologue of Wdr48 (WD repeat domain 48) from Rattus norvegicus.
WDR48 is a homologue of wdr48 (WD repeat domain 48) from Danio rerio.
WDR48 is a homologue of Os12g0165000 (Os12g0165000) from Oryza sativa Japonica Group.
WDR48 is a homologue of LOC100333793 (WD repeat-containing protein 48-like) from Danio rerio.
WDR48 is a homologue of CG9062 (CG9062 gene product from transcript CG9062-RB) from Drosophila melanogaster.
WDR48 is a homologue of beta-transducin (hypothetical protein) from Caenorhabditis elegans.
WDR48 is a homologue of AT3G05090 (transducin family protein / WD-40 repeat family protein) from Arabidopsis thaliana.
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