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The lowest [ Gluc] during the IT identified the GT. Paper-12875755.
GlcCer was found to fit well the cleft of the crystal structure of KLrP. Paper-12523113.
Uptake of LTC4 or E2- Gluc by human CMVs showed little inter-subject variability (2-5-fold). Paper-12005324.
Capillary blood glucose ( CBG) was determined hourly, and the insulin infusion rate was modified accordingly. Paper-12747251.
The EMR (prebreakfast CBG-midsleep CGB) was inversely related to the midsleep CBG level (r = -.45, P less than .001). Paper-5996360.
In addition, knockdown of the endogenous KLrP by small interfering RNA increased the cellular level of GlcCer. Paper-12523113.
The crystal structure of human cytosolic beta-glucosidase unravels the substrate aglycone specificity of a family 1 glycoside hydrolase. Paper-13294977.
Blood glucose and insulin concentrations were lower, and free fatty acids higher in Gal compared with Gluc/Gal and Gluc/Fru. Paper-13601615.
The purified recombinant KLrP hydrolyzed 4-methylumbelliferyl-glucose, C6-NBD- GlcCer, and authentic GlcCer at pH 6. Paper-12523113.
Uptake clearance among different species varied by approximately ten-fold (rat > dog = human > monkey) for LTC4 and less than two-fold for E2- Gluc. Paper-12005324.
Collectively, KLrP was identified as a cytosolic neutral glycosylceramidase that could be involved in a novel nonlysosomal catabolic pathway of GlcCer. Paper-12523113.
The usual treatment group had a total of 87 CBG measurements of <or=3.6 mmol/l during the study, and only 1 such measurement (3.5 mmol/l) was recorded in the GLP-1 group. Paper-10137355.
There was no difference in mean intrapartum maternal CBG levels (103.9 +/- 8.7 mg/dL and 103.2 +/- 17.9 mg/dL in the rotating fluids and insulin drip group, respectively, P = .89). Paper-12244887.
CONCLUSIONS: The absorption of dietary flavonoid glycosides in humans involves a critical deglycosylation step that is mediated by epithelial beta-glucosidases ( LPH and CBG). Paper-9886941.
The results are in sharp contrast to those observed in human pregnancies in which both hSBP and hCBG are increased severalfold during pregnancy, including at term. Paper-3132502.
Uptake of [3H]-leukotriene C4 ( LTC4) and [3H]-estradiol-17beta-d-glucuronide ( E2- Gluc) was determined at a low substrate concentration and/or by kinetic measurements (K(m) and V(max)). Paper-12005324.
Correlation of in vitro data with in vivo findings was achieved by determining the biliary clearance of E2- Gluc in rats after a single i.v. dose and with literature in vivo data for LTC4. Paper-12005324.
Unlike klotho protein, it possesses neither a signal sequence nor a transmembrane domain, suggesting that it is a cytosolic protein, and thus was termed cytosolic beta-glucosidase-like protein-1 ( cBGL1). Paper-8555562.
Among this family, only the KL-related protein ( KLrP) is capable of degrading C6-NBD- GlcCer when expressed in CHOP cells, in which Myc-tagged KLrP was exclusively distributed in the cytosol. Paper-12523113.
Based on the substrate specificity of the human enzymes, sequence alignment of family 1 enzymes and analysis of the hCBG structural model, we selected and mutated putative substrate (aglycone) binding site residues. Paper-9920001.
Cytosolic beta-glucosidase (EC 3.2.1.21) from mammalian liver is a member of the family 1 glycoside hydrolases and is known for its ability to hydrolyse a range of beta-D-glycosides, including beta-D-glucoside and beta-D-galactoside. Paper-8982608.
We recently reported the crystal structure of KLrP in complex with glucose [Y. Hayashi, N. Okino, Y. Kakuta, T. Shikanai, M. Tani, H. Narimatsu, M. Ito, Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase, J. Biol. Chem. 282 (2007) 30889-30900]. Paper-12908975.
CB with Giemsa ( CBG) revealed weak heterochromatic blocks in the telomeric regions of some chromosomes and conspicuous bands on the short arms of one chromosome pair, where nucleolar organizer regions (NORs) were evidenced by silver-staining. Paper-9815297.
To estimate the frequency of an early-morning glucose rise (EMR) in relatively unselected children with insulin-dependent diabetes mellitus ( IDDM), we assessed capillary blood glucose ( CBG) at midsleep (0200-0430) and prebreakfast (0700-0800) in 97 children with diabetes at camp. Paper-5996360.
Diabetic keto-acidosis (DKA) requires prompt diagnosis and all patients arriving emergency with dehydration, shock, coma, severe respiratory difficulty and evidence of any major illness should be tested for capillary blood glucose ( CBG) and urinary ketones urgently not to miss DKA. Paper-12280952.
Differences in in vitro uptake clearance (10-fold) between LTC4 and E2- Gluc in rat CMVs seemed to correlate with differences in their biliary clearance (4-fold) in rats, consistent with LTC4 and E2- Gluc being a high and a low clearance substrate, respectively. Paper-12005324.
When klotho and cBGL1 gene expression was examined in renal cell carcinoma tissues, both klotho and cBGL1 mRNA levels in tumors were lower than those in nontumor regions, suggesting that renal epithelial cells may lose klotho and cBGL1 gene expression during the course of malignant transformation. Paper-8555562.
Sample preparation for systematic toxicological screening analysis (STA) in urine by gas chromatography-mass spectrometry (GC-MS) generally involves cleavage of conjugates by acid hydrolysis (Hy) or enzymatic hydrolysis ( Gluc) followed by liquid-liquid extraction (LLE) or solid-phase extraction (SPE), and derivatization, e.g., acetylation (Ac). Paper-13550938.
These synonyms are used for gene GBA3 (glucosidase, beta, acid 3 (cytosolic)): MGC126878, MGC104276, KLrP, GLUC, Cytosolic beta-glucosidase-like protein 1, Cytosolic beta-glucosidase, CBGL1, CBG.
These accession numbers are used for gene GBA3: Q6NSF4 (UNIPROT__AC), Q32LY7 (UNIPROT__AC), AAI09378 (NCBI_GENBANK__AC), AAI01830 (NCBI_GENBANK__AC).
GBA3 is a homologue of zgc:112375 (zgc:112375) from Danio rerio.
GBA3 is a homologue of Os01g0897600 (Os01g0897600) from Oryza sativa Japonica Group.
GBA3 is a homologue of GBA3 (glucosidase, beta, acid 3 (cytosolic)) from Pan troglodytes.
GBA3 is a homologue of GBA3 (glucosidase, beta, acid 3 (cytosolic)) from Canis lupus familiaris.
GBA3 is a homologue of Gba3 (glucosidase, beta, acid 3 (cytosolic)) from Rattus norvegicus.
GBA3 is a homologue of BGLU42 (BGLU42 (BETA GLUCOSIDASE 42); beta-glucosidase/ catalytic/ cation binding /...) from Arabidopsis thaliana.
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Concept & Implementation by Robert Hoffmann.