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In contrast to Fbn1-/- mice, Fbn2 null mice had a well developed and morphologically normal aortic wall. Paper-11406742.
Mutations of the mouse Twist and sy ( fibrillin 2) genes induced by chemical mutagenesis of ES cells. Paper-8838273.
The results position Fbn2 between the D18Mit35 and Pdgfrb loci in the central region of mouse Chr 18. Paper-171815.
Together, these results imply functional interaction between Fbn2-rich microfibrils and BMP-7 signaling. Paper-9030366.
Transcriptional regulation of fibrillin-2 gene by E2F family members in chondrocyte differentiation. Paper-13641241.
Here, we report the isolation of genomic clones of the corresponding mouse fibrillin genes ( Fbn-1 and Fbn-2). Paper-7798637.
Of mice and Marfan: genetic linkage analyses of the fibrillin genes, Fbn1 and Fbn2, in the mouse genome. Paper-171815.
Recent work has revealed the existence of two structurally related microfibrillar components, termed fibrillin-1 and fibrillin-2. Paper-226930.
We then sublocalized the fibrillin genes to bands 2F ( Fbn-1) and 18D-E1 ( Fbn-2) by fluorescence in situ hybridization. Paper-7798637.
On the other hand, mice double heterozygous for null Fbn2 and Bmp7 alleles display the combined digit phenotype of both nullizygotes. Paper-9030366.
In the majority of cases, fibrillin-2 transcripts appear earlier and accumulate for a shorter period of time than fibrillin-1 transcripts. Paper-226930.
Relaxin regulates fibrillin 2, but not fibrillin 1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin. Paper-9823127.
The 5'-flanking region of the fibrillin-2 gene contains potential binding sites for E2F, Runx, AP-2, and Sox transcription factors. Paper-13641241.
The promoter activity of fibrillin-2 decreased markedly following deletion and mutagenesis of the E2F binding site between -143 and -136 bp. Paper-13641241.
We have found that relaxin specifically inhibits a microfibril component, fibrillin 2 ( FBN2), without affecting fibrillin 1 ( FBN1). Paper-9823127.
These results indicated that coordinated expression of the E2F family is critical for the transcriptional regulation of fibrillin-2 during chondrogenesis. Paper-13641241.
Greater osteoclastogenic potential of Fbn2(-/-) osteoblasts was largely accounted for by up-regulation of the Rankl gene secondary to heightened TGFβ activity. Paper-15406287.
Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly. Paper-9170476.
By analyzing a mapping panel of mouse x rodent somatic hybrid cell lines, we have assigned the Fbn-1 gene to mouse chromosome 2 and the Fbn-2 gene to mouse chromosome 18. Paper-7798637.
Accordingly, we propose that fibrillin-1 provides mostly force-bearing structural support, whereas fibrillin-2 predominantly regulates the early process of elastic fiber assembly. Paper-226930.
Consistent with a specialized function of fibrillin-2, electron microscopy visualized ultrastructurally different microfibrils in Fbn1 null compared with control cell cultures. Paper-11406742.
We recently found that fibrillin-1 and fibrillin-2 control bone formation by regulating osteoblast differentiation through the differential modulation of endogenous TGFβ and bone morphogenetic protein signals. Paper-15406287.
Mutations in fibrillin-1 or fibrillin-2, the major structural components of extracellular microfibrils, cause pleiotropic manifestations in Marfan syndrome and congenital contractural arachnodactyly, respectively. Paper-15406287.
Immunostaining of wild-type and mutant skin samples indicate no detectable differences in the expression and deposition of matrilin-2 binding partners including collagen I, laminin- nidogen complexes, fibrillin-2 and fibronectin. Paper-10493046.
This conclusion was based on the findings that blockade of TGFβ signaling blunts Rankl up-regulation in Fbn2(-/-) osteoblasts and bones and that systemic TGFβ antagonism improves locally induced osteolysis in Fbn2(-/-) mice. Paper-15406287.
The importance of the cell in this process was further underscored by novel data demonstrating that keratinocytes selectively secrete fibrillin-1 into the matrix and not into the medium and can differentiate between fibrillin-1 and fibrillin-2. Paper-9128903.
Synthesis of fibrillin-1 correlates with late morphogenesis and the appearance of well-defined organ structures; fibrillin-2 synthesis, on the other hand, coincides with early morphogenesis and, in particular, with the beginning of elastogenesis. Paper-226930.
Restriction fragment length polymorphisms ( RFLPs) between the progenitors of an interspecific backcross involving AEJ/Gn and Mus spretus mice were used to establish the segregation patterns of the murine homologs, Fbn1 and Fbn2, in the backcross progeny. Paper-171815.
Collectively, these data demonstrate that involvement of fibrillin-2 in the initial assembly of the aortic matrix overlaps in part with fibrillin-1 and that continued fibrillin-1 deposition is absolutely required for the maturation and function of the vessel during neonatal life. Paper-11406742.
The evidence includes the identification of fibrillin 2, a microfibrillar component structurally related to fibrillin 1; the differential pattern of gene expression of the two fibrillin; and the association of fibrillin 2 mutations with congenital contractural arachnodactyly. Paper-734150.
Results obtained from studies of wild type and fibrillin-1 null tissues, using monoclonal and polyclonal antibodies with defined epitopes, demonstrated that N-terminal fibrillin-2 epitopes are masked in postnatal microfibrils and can be revealed by enzymatic digestion or by genetic ablation of Fbn1. Paper-15190429.
These synonyms are used for gene Fbn2 (fibrillin 2): sy, Sne, sne, mKIAA4226, KIAA4226, Fibrillin-2, Fib-2, Fbn-2, BC063774.
These accession numbers are used for gene Fbn2: U20217 (NCBI_GENBANK__AC), Q63957 (UNIPROT__AC), Q571J3 (UNIPROT__AC), AK220196 (NCBI_GENBANK__AC).
Fbn2 is a homologue of fbn2b (fibrillin 2b) from Danio rerio.
Fbn2 is a homologue of FBN2 (fibrillin 2) from Homo sapiens.
Fbn2 is a homologue of FBN2 (fibrillin 2) from Pan troglodytes.
Fbn2 is a homologue of FBN2 (fibrillin 2) from Canis lupus familiaris.
Fbn2 is a homologue of FBN2 (fibrillin 2) from Bos taurus.
Fbn2 is a homologue of FBN2 (fibrillin 2) from Gallus gallus.
Fbn2 is a homologue of Fbn2 (fibrillin 2) from Rattus norvegicus.
Fbn2 is a homologue of AgaP_AGAP010021 (AGAP010021-PA) from Anopheles gambiae str. PEST.
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