Click here for the function of Hoxa1.
Edit this page in Wiki Genes - Hoxa1 or see Wiki Gene.
Hox-1.6: a mouse homeo-box-containing gene member of the Hox-1 complex. Paper-5464783.
Hoxa1 and Krox-20 synergize to control the development of rhombomere 3. Paper-1756556.
Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse. Paper-2149285.
The truncated Hoxa1 protein interacts with Hoxa1 and Pbx1 in stem cells. Paper-13590677.
Hox-1.6, a mouse homeo-box-containing gene member of the Hox-1 complex, is described. Paper-5464783.
Separately, mutations in Hoxa1 and Hoxb1 have profoundly different effects on hindbrain development. Paper-8296414.
Compensatory defects associated with mutations in Hoxa1 restore normal palatogenesis to Hoxa2 mutants. Paper-8342114.
The loss of Hoxa1 or Hoxa2 function affects the development of multiple neural crest-derived structures. Paper-8342114.
Targeted insertion results in a rhombomere 2-specific Hoxa2 knockdown and ectopic activation of Hoxa1 expression. Paper-9637502.
Unexpectedly, in Hoxa1/ Hoxa2 double mutants, the penetrance of cleft palate is dramatically reduced. Paper-8342114.
Hoxa1 and Hoxb1 synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch. Paper-1389976.
Genetic interactions between Hoxa1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning. Paper-1389966.
Orientation of the Hoxa complex and placement of the Hd locus distal to Hoxa2 on mouse chromosome 6. Paper-999052.
We examined the interchangeability of Hoxa1 and Hoxb1 in mouse development by swapping their protein-coding regions. Paper-12165543.
Synergy between Hoxa1 and Hoxb1: the relationship between arch patterning and the generation of cranial neural crest. Paper-9052452.
Hoxa1 and Hoxb1 have overlapping synergistic roles in patterning the hindbrain and cranial neural crest cells. Paper-9052452.
Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development. Paper-8296414.
Expression of the mouse labial-like homeobox-containing genes, Hox 2.9 and Hox 1.6, during segmentation of the hindbrain. Paper-7160568.
Characterization of Pax-6 and Hoxa-1 binding to the promoter region of the neural cell adhesion molecule L1. Paper-135339.
Further, we established a mouse line in which we have inserted the 107 bp Hoxb1 autoregulatory enhancer into the Hoxa1 promoter. Paper-12165543.
Hox 2.9 and Hox 1.6 are the only two mouse members of the labial-like family of homeobox-containing genes as yet identified. Paper-7160568.
The analysis of mice mutant for both Hoxa1 and Hoxb1 suggests that these two genes function together to pattern the hindbrain. Paper-8296414.
The transcription factor genes Hoxa1 and Krox-20 have been shown to play important roles in vertebrate hindbrain segmentation. Paper-1756556.
Neuronal defects in the hindbrain of Hoxa1, Hoxb1 and Hoxb2 mutants reflect regulatory interactions among these Hox genes. Paper-10066215.
Evolutionary-conserved enhancers direct region-specific expression of the murine Hoxa-1 and Hoxa-2 loci in both mice and Drosophila. Paper-225929.
In the developing vertebrate hindbrain Hoxa1 and Hoxb1 play important roles in patterning segmental units (rhombomeres). Paper-1389966.
The equivalent gene in the Hox 1 cluster is Hox 1.6 which shows extensive similarity to Hox 2.9 both within and outside the homeodomain. Paper-7160568.
Inter- and intrasexual variation in digit ratios may be ultimately controlled by modulation of the expression of Hoxa and Hoxd genes. Paper-11101956.
Segmentation transcription factors Hoxa1, Krox20 and kreisler are expressed in the future rhombomeres r4-r5, r3 and r5, r5-r6, respectively. Paper-9506985.
At gestation day 9.5, two domains of strong Hoxb-1 expression are found in the anterior region of the hindbrains of Hoxa-1 transgenic embryos. Paper-140241.
The Hoxa1 mutant phenotype is consistent with a partial misspecification of the presumptive r4 territory that results from partial Hoxb1 activation. Paper-10066215.
The analysis of Hoxa1 and Hoxb1 null mutants suggested that these genes are involved in distinct aspects of hindbrain segmentation and specification. Paper-1389976.
Co-incubation with folic acid blocked ethanol-induced teratogenesis, with up-regulated Hoxa1 and down-regulated miR-10a ( P < 0.01). Paper-13628958.
The r4 rhythm generator appears to be homologous to a murine respiratory parafacial neuronal system developing in r4 under the control of Krox20 and Hoxa1. Paper-10602372.
We identified three independent enhancers which direct distinct portions of the Hoxa-1 and Hoxa-2 expression domains during early murine embryogenesis. Paper-225929.
Exposure of midgastrulation mouse embryos to retinoic acid induced anteriorized expression of the Hoxa-1 ( Hox-1.6) and Hoxb-1 ( Hox-2.9) genes. Paper-7585194.
In E8.0-8.5 Hoxa-1 mutants, cad6 expression was suppressed in the region of rhombomeres 4 to 6, although that in the other regions was not essentially affected. Paper-985802.
Two of these genes, Hoxa1 and Hoxa2, have been shown to be required for proper patterning of the early mouse hindbrain and the associated neural crest. Paper-2149285.
Critical to the model is the demonstration that Hoxa1 activity is required to set the anterior limit of Hoxb1 expression at the presumptive r3/4 rhombomere boundary. Paper-2149285.
Double mutant analysis with this Hoxb1(3'RARE) allele and other targeted loss-of-function alleles from both Hoxa1 and Hoxb1 reveals synergy between these genes. Paper-1389966.
The hindbrain patterning defects were analyzed in embryos individually mutant for Hoxa1 and Hoxa2 in greater detail and extended to embryos mutant for both genes. Paper-2149285.
Neurofilament staining and retrograde labelling of motor neurons indicated that Hoxa1 and Hoxb1 synergise in patterning the VIIth through XIth cranial nerves. Paper-1389976.
Taken together, our results unveil an extensive functional synergy between Hoxa1 and Hoxb1 that was not anticipated from the phenotypes of the simple null mutants. Paper-1389976.
No ectopic Hoxb-1 expression is detected in rhombomere 5 and the expression of Hoxa-3 and Krox-20 in this region is unchanged in the Hoxa-1 transgenic embryos. Paper-140241.
Strong genetic interactions between Hoxa1 and Hoxb1 were uncovered by introducing the Hoxb1(3'RARE) and Hoxb1 null mutations into the Hoxa1 null genetic background. Paper-1389976.
From these data a model is proposed to describe how Hoxa1, Hoxa2, Hoxb1, Krox20 ( Egr2) and kreisler function together to pattern the early mouse hindbrain. Paper-2149285.
This suggests a failure to initiate rather than maintain the specification of r4 identity and defines new roles for both Hoxb1 and Hoxa1 in early patterning events in r4. Paper-1389966.
We then studied the effect of Hoxa-1 mutation on the expression of cad6, as their expressions spatiotemporally overlapped with each other in the early posterior hindbrain. Paper-985802.
Local alterations of Krox-20 and Hox gene expression in the hindbrain suggest lack of rhombomeres 4 and 5 in homozygote null Hoxa-1 ( Hox-1.6) mutant embryos. Paper-7589168.
Loss of retinoic acid receptor gamma function in F9 cells by gene disruption results in aberrant Hoxa-1 expression and differentiation upon retinoic acid treatment. Paper-102149.
Similar ectopic domains of beta-galactosidase activity are detected in dual transgenic embryos containing both beta-actin/ Hoxa-1 transgene and a Hoxb-1/lacZ reporter construct. Paper-140241.
Interestingly, this abnormal development in the Hoxa-1 transgenic mice is associated with ectopic expression of the Hoxb-1 ( Hox 2.9) gene in select hindbrain regions. Paper-140241.
Differences in gene expression between wild type and Hoxa1 knockout embryonic stem cells after retinoic acid treatment or leukemia inhibitory factor ( LIF) removal. Paper-10786070.
Mouse embryos in culture were used to examine the effect of ethanol treatment on expression of the putative target genes of miR-10a ( Hoxa1 and other Hox members) at mRNA and protein level. Paper-13628958.
Interestingly, although the RARE is not required for the spatiotemporal control of colinear expression of the Hoxa genes, it is absolutely required for correct Hoxa-2 expression in rhombomere 5. Paper-903095.
Failure to express Hoxb1 to this boundary in Hoxa1 mutant embryos initiates a cascade of gene misexpressions that result in misspecification of the hindbrain compartments from r2 through r5. Paper-2149285.
Therefore, we have delineated the functional requirements in hindbrain neuronal patterning that follow the establishment of the genetic regulatory hierarchy between Hoxa1, Hoxb1 and Hoxb2. Paper-10066215.
This has allowed us to examine neural crest and arch patterning defects that originate exclusively from the neuroepithelium as a result of the simultaneous loss of Hoxa1 and Hoxb1 in this tissue. Paper-9052452.
Since Hoxa1 is expressed early and Hoxc13 is expressed late in mouse embryogenesis, this study shows that single-copy GFP gene fusions can be used through most of mouse embryogenesis. Paper-1625468.
Additionally, Hoxa1(-/-) ES cells express high levels of various endodermal markers, including Gata4 and Dab2, and express much less Fgf5 after leukemia inhibitory factor ( LIF) withdrawal. Paper-10786070.
Reverse transcriptase PCR identified Hoxa-1, Hoxa-3, Hoxa-5, Hoxb-3, Hoxb-4, Hoxb-6, Hoxb-7, and Hoxb-8 transcripts from within this tissue at 11.5 day post coitum (E11.5). Paper-1300427.
Hoxa1 mutations disrupt the rhombomeric organization of the hindbrain, whereas Hoxb1 mutations do not alter the rhombomeric pattern, but instead influence the fate of cells originating in rhombomere 4. Paper-8296414.
We suggest that these differences are not the consequences of different functional roles for these gene products, but rather reflect differences in the kinetics of Hoxa1 and Hoxb1 gene expression. Paper-8296414.
Here, we show that the fluorescent signals produced by single-copy, targeted GFP in-frame fusions with two different murine Hox genes, Hoxa1 and Hoxc13, are readily detectable by using confocal microscopy. Paper-1625468.
Strikingly, the newly generated autoregulatory Hoxa1 gene can deliver the functionality of both paralogs in these mice, providing normal viability as well as proper facial nerve formation even in the Hoxb1 mutant background. Paper-12165543.
In this study, genetic analysis of double mutants demonstrates that both Hoxa1 and Hoxb1 participate in the establishment and maintenance of Hoxb1 expression in rhombomere 4 through auto- and para-regulatory interactions. Paper-1389966.
To understand to what extent such regulatory interactions shape neuronal patterning in the hindbrain, we analysed neurogenesis, neuronal differentiation and motoneuron migration in Hoxa1, Hoxb1 and Hoxb2 mutant mice. Paper-10066215.
The combination of an ectoderm-specific regulatory mutation in the Hoxb1 locus and the Hoxa1 mutant genetic background results in an ectoderm-specific double mutation, leaving the other germ layers impaired only in Hoxa1 function. Paper-9052452.
Two enhancers mediate hindbrain-specific expression, being active in either rhombomere 2, the most anterior rhombomere expressing Hoxa-2, or in rhombomere 4, a region where Hoxa-1 and Hoxa-2 have been shown to exert critical developmental roles. Paper-225929.
This detailed analysis has enabled us to draw the following conclusions: (1) There are extensive similarities in the temporal and spatial expression of Hox 2.9 and Hox 1.6, throughout the period that both genes are expressed in the embryo (7 1/2 to 10 days). Paper-7160568.
We previously identified a 3' enhancer called the RAIDR5, which contained a DR5 retinoic acid response element (RARE) and was responsible for the retinoic acid (RA)- associated expression of the murine Hoxa-1 gene in teratocarcinoma cells. Paper-869577.
In strong support of the idea that Hoxa1 and Hoxb1 have overlapping functions, Hoxa1/ Hoxb1 double mutant homozygotes exhibit a plethora of defects either not seen, or seen only in a very mild form, in mice mutant for only Hoxa1 or Hoxb1. Paper-8296414.
These findings suggest that cad6 may contribute to the formation of the segmental structure of the early brain through its ability to confer specific adhesiveness on cells and that Hoxa-1 may be required for early cad6 expression in the posterior hindbrain. Paper-985802.
Neonatal respiratory abnormalities in Krox20(-/-), Hoxa1(-/-) and kreisler mutant mice indicate the vital role of a para-facial ( Krox20-dependent, rhombomere 4-derived) respiratory group, that is distinct from the more caudal rhythm generator called Pre-B??tzinger complex. Paper-12303263.
These include genes encoding Hoxa-1 ( Hox-1.6) and the extracellular matrix proteins laminin B1 and collagen type IV (alpha 1), all of which are RA inducible in wild-type F9 embryonal carcinoma cells but are not significantly induced in the RAR gamma-/- lines. Paper-102149.
These phenotypic manifestations become more severe in the context of the additional inactivation of one allele of the Krox-20 gene, demonstrating that Hoxa1 and Krox-20 synergize in a dosage-dependent manner to specify r3 identity and odd- versus even-numbered rhombomere characters. Paper-1756556.
These findings reveal that Hoxa2 is a target gene of Hoxb1 and permit us to develop a gene regulatory network for r4, whereby Hoxa2, along with Hoxb1, Hoxb2 and Hoxa1, is integrated into a series of auto- and cross-regulatory loops between Hox genes. Paper-13108849.
We examined in transgenic mice the DNA regulatory elements that determine the temporal and spatially restricted expression of two of the earliest and most anteriorly expressed murine genes, Hoxa-1 and Hoxa-2, which are homologues of the labial and proboscipedia genes of Drosophila. Paper-225929.
To analyse further the function of Hox 2.9 during development and to determine if the other mouse labial-like gene Hox 1.6, displays similar properties, we have investigated the expression patterns of these two genes and an additional rhombomere-specific gene, Krox 20, on consecutive embryonic sections at closely staged intervals. Paper-7160568.
These synonyms are used for gene Hoxa1 (homeobox A1): Hoxa-1, Hox-1.6, Homeotic protein ERA-1-993, Homeobox protein Hox-A1, Homeobox protein Hox-1.6, Homeoboxless protein ERA-1-399, Era-1, ERA1, Early retinoic acid 1, early retinoic acid.
These accession numbers are used for gene Hoxa1: P15463 (UNIPROT__AC), B9EHK8 (UNIPROT__AC), AK143943 (NCBI_GENBANK__AC), AAA37559 (NCBI_GENBANK__AC).
Hoxa1 is a homologue of hoxa1a (homeo box A1a) from Danio rerio.
Hoxa1 is a homologue of HOXA1 (homeobox A1) from Homo sapiens.
Hoxa1 is a homologue of HOXA1 (homeobox A1) from Canis lupus familiaris.
Hoxa1 is a homologue of HOXA1 (homeobox A1) from Bos taurus.
Hoxa1 is a homologue of HOXA1 (homeobox A1) from Pan troglodytes.
Hoxa1 is a homologue of Hoxa1 (homeo box A1) from Rattus norvegicus.
Hoxa1 is a homologue of ceh-13 (Homeobox) from Caenorhabditis elegans.
Important links !
iHOP - Information Hyperlinked over Proteins .
Concept & Implementation by Robert Hoffmann.