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5. The KLF6 mRNA level in corneal layers remained relatively constant until P60. Paper-10635765.
Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6. Paper-10821393.
TGF-beta1 protein was also up-regulated in a pattern parallel to that of Zf9. Paper-11215560.
The KLF6 transcript was found in the lens pit at E10.5 and in the ectoderm and mesenchyme at E12. Paper-10635765.
SM2, SM1 and IM contain MLC1s; SM1, IM, FM2 and FM3 contain MLC1f; FM2 and FM1 contain MLC3f. Paper-6388169.
Krüppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1. Paper-10740147.
Repression of Dlk1 requires HDAC3 deacetylase activity, which is recruited to the endogenous Dlk1 promoter where it interacts with KLF6. Paper-10740147.
Studies of mutants lacking FM or FM2 enhancer demonstrated that these enhancers indeed regulate Otx2 expression in forebrain and midbrain. Paper-10488501.
Antisense oligonucleotides to Zf9 markedly blunted the induction of Zf9 and TGF-beta1, and significantly inhibited the apoptotic response to ATP depletion. Paper-11215560.
Otx2 expression in the forebrain and midbrain was found to be regulated by two distinct enhancers (FM and FM2) located at 75 kb 5' upstream and 115 kb 3' downstream. Paper-10488501.
CONCLUSION: Induction of Zf9 and its transactivating factor TGF-beta1 may play a critical and hitherto unrecognized role in the early apoptotic response to ischemic renal injury. Paper-11215560.
Western blot analysis indicated that c-Jun (an AP-1 protein), Kruppel-like factor 6 (KFL6), and inducible nitric oxide synthase ( iNOS) were upregulated sequentially in that order. Paper-10479313.
RESULTS: The maximally induced gene (21-fold at 3 hours of reflow) was Zf9, a Kruppel-like transcription factor involved in the regulation of transforming growth factor-beta1 ( TGF-beta1). Paper-11215560.
A key mechanism of growth inhibition by wild-type KLF6 is through p53-independent up-regulation of p21(WAF1/ cip1) ( CDKN1A), which is abrogated in several tumor-derived mutants. Paper-11042188.
In cultured human proximal tubule cells, induction of ischemia by partial adenosine triphosphate ( ATP) depletion resulted in a rapid up-regulation of both Zf9 and of TGF-beta1 proteins. Paper-11215560.
KLF6 degradation occurred in the presence or absence of p53, was associated with ubiquitination, mediated by the proteasome ( half-life 16min, unstimulated), and independent of caspases and calpain. Paper-12360192.
Chromatin immunoprecipitation assay analysis revealed that the endogenous KLF-6/ Zf9 binds the BS5-B elements that contain the CACCC motif, which is a consensus recognition sequence for other proteins in the KLF family. Paper-9252185.
At E10.5 Otx1-/-Otx2DeltaFM/DeltaFM mutants, in which Otx2 expression under the FM2 enhancer remained, exhibited almost complete loss of the entire diencephalon and mesencephalon; the telencephalon did, however, develop. Paper-10488501.
A single lysine-to-arginine point mutation (K209R) derived from prostate cancer reduces acetylation of KLF6 and abrogates its capacity to up-regulate endogenous p21(WAF1/ cip1) and reduce cell proliferation. Paper-11042188.
Forced expression of KLF6 strongly inhibits Dlk1 expression in preadipocytes and NIH 3T3 cells in vivo, whereas down-regulation of KLF6 in 3T3-L1 cells by small interfering RNA prevents adipogenesis. Paper-10740147.
Analysis of the distribution of native myosins (FM1, FM2, FM3, IM, SM, in order of decreasing gel migration rate) in dystrophic muscles revealed increased proportions of the slower-migrating forms, when compared with the distribution in the corresponding normal muscles. Paper-4466502.
We have identified Krüppel-like factor-6 ( KLF6), a recently described tumor suppressor gene, as a repressor of the proto-oncogene Delta-like 1 ( Dlk1), a gene encoding a transmembrane protein that inhibits adipocyte differentiation. Paper-10740147.
To explore the potential role of Klf6 in mouse development, we analyzed Klf6-/- mice and found that the homozygous mutation is embryonic lethal by embryonic day (E) 12.5 and associated with markedly reduced hematopoiesis and poorly organized yolk sac vascularization. Paper-10821393.
Here, we demonstrate that KLF6 protein is rapidly degraded when apoptosis is induced via the intrinsic pathway by cisplatin, adriamycin, or UVB irradiation in multiple cell lines (HCT116, SW40, HepG2, PC3-M, Skov3, NIH-3T3, 293T, GM09706, and MEF, IMR-90). Paper-12360192.
Here we show by chromatin immunoprecipitation that transactivation of p21(WAF1/ cip1) by KLF6 occurs through its direct recruitment to the p21(WAF1/ cip1) promoter and requires acetylation by histone acetyltransferase activity of either cyclic AMP-responsive element binding protein-binding protein or p300/ CBP-associated factor. Paper-11042188.
These synonyms are used for gene Klf6 (Kruppel-like factor 6): Zf9, R75280, Krueppel-like factor 6, Ierepo3, Ierepo1, FM6, FM2, CPBP, Cpbp, Core promoter element-binding protein, Copeb, C86813, BCD1, AI448727.
These accession numbers are used for gene Klf6: Q8BPQ2 (UNIPROT__AC), Q3UGJ1 (UNIPROT__AC).
Klf6 is a homologue of KLF6 (Kruppel-like factor 6) from Canis familiaris.
Klf6 is a homologue of KLF6 (Kruppel-like factor 6) from Bos taurus.
Klf6 is a homologue of KLF6 (Kruppel-like factor 6) from Gallus gallus.
Klf6 is a homologue of KLF6 (Kruppel-like factor 6) from Homo sapiens.
Klf6 is a homologue of KLF6 (Kruppel-like factor 6) from Pan troglodytes.
Klf6 is a homologue of Klf6 (Kruppel-like factor 6) from Rattus norvegicus.
Klf6 is a homologue of copeb (core promoter element binding protein) from Danio rerio.
Important links !
iHOP - Information Hyperlinked over Proteins .
Concept & Implementation by Robert Hoffmann.