The most recent information on Fcr is here. Click here for the function of Fcr. Edit this page in Wiki Genes - Fcr or see Wiki Gene. Mice lacking the FcR gamma have no functional FcR for IgG or IgE. Paper-788206. A new Fc receptor on mouse macrophages binding IgG3. Paper-3803048. CD3 and immunoglobulin G Fc receptor regulate cerebellar functions. Paper-13320242. IgG1 and IgG2b share the Fc receptor on mouse macrophages. Paper-3572444. Polymorphism of Fc receptor on murine B cells is Igh-linked. Paper-4831450. Staining to FcR and CD45 was combined with a DNA stain Hoechst 33342. Paper-7842281. Site of binding of mouse IgG2b to the Fc receptor on mouse macrophages. Paper-3205879. The mouse Fc receptor for IgG ( Ly-17): molecular cloning and specificity. Paper-5471947. A polymorphic Fc receptor for mouse IgG2b on human B cells and monocytes. Paper-6924444. The association between FcRgamma and NKR-P1 is independent of Fc receptor complexes. Paper-1264381. The low affinity IgE Fc receptor ( CD23) participates in B cell activation. Paper-7465262. Isolation and characterization of the Fc receptor from the fetal yolk sac of the rat. Paper-6840568. GRM1 also did not block Fc receptor in an erythrocyte antibody rosette assay. Paper-5621654. Furthermore, phosphorylation of the FcR induced its association with Ship. Paper-930366. CH3 domain of IgG as binding site to Fc receptor on mouse lymphocytes. Paper-2250034. Simultaneous blocking of FcR and CR3 further increased the inhibition of phagocytosis. Paper-7684808. The Fc receptor for mouse IgG1 plays a role in antibody-induced T cell proliferation. Paper-4763260. Definition of an Fc receptor-related gene ( FcRX) expressed in human and mouse B cells. Paper-9614590. Cells from these lines were all adherent, phagocytic, Fc receptor positive, and esterase positive. Paper-4356495. We therefore investigated the possible role of Rho in Fc receptor-mediated phagocytosis. Paper-1171153. Antibodies to HA and NA augment uptake of influenza A viruses into cells via Fc receptor entry. Paper-7149748. Regulation of macrophage Fc receptor expression and phagocytosis by histidine-rich glycoprotein. Paper-7471719. The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60. Paper-12080686. Evidence for clustering of H-2K, H-2D, and the Fc receptor on the membranes of B cells. Paper-2483879. Macrophage membrane potential changes associated with gamma 2b/gamma 1 Fc receptor-ligand binding. Paper-4280549. The FcR has been purified using rat anti-mouse FcR monoclonal antibody which blocks FcRII. Paper-3786418. Finally, FcR-bearing K cells bind to target cell-bound, rather than free, IgG2a or IgG2b molecules. Paper-4864899. A major histocompatibility complex class I-related Fc receptor for IgG on rat hepatocytes. Paper-219233. B-cell-stimulatory factor 1 reverses Fc receptor-mediated inhibition of B-lymphocyte activation. Paper-5492365. Other agents also shown to induce Fc receptor expression were LPS and certain batches of fetal calf sera. Paper-3471802. The sequence TTAC(N)4CACC (-135 and -124 bp) is similar to the IL-4 response region in the Fc receptor II. Paper-10344086. Mice deficient in FcgammaRIIb, an inhibitory immunoglobulin G Fc receptor, have enhanced immune responses. Paper-10512692. The structure and expression of the guinea pig Fc receptor for IgG1 and IgG2 (Fc gamma 1/gamma 2R). Paper-9325. Quantitative and qualitative analysis of the Fc receptor for IgE ( Fc epsilon RII) on human eosinophils. Paper-5822829. IL-3 promotes production of IL-4 by splenic non-B, non-T cells in response to Fc receptor cross-linkage. Paper-6840005. Colocalization of F-actin and talin during Fc receptor-mediated phagocytosis in mouse macrophages. Paper-22778. Cloning of cDNAs for new subtypes of murine low-affinity Fc receptor for IgE ( Fc epsilon RII/ CD23). Paper-7962985. Syk and Zap-70 are related protein-tyrosine kinases implicated in antigen and Fc receptor signaling. Paper-700420. The human mononuclear phagocyte high-affinity Fc receptor, FcRI, defined by a monoclonal antibody, 10.1. Paper-5490251. After 24 hr in culture the cells were phagocytic, contained non-specific esterase and exhibited an Fc receptor. Paper-3508864. Fc receptor-independent development of autoimmune glomerulonephritis in lupus-prone MRL/lpr mice. Paper-9759786. Molecular cloning and expression of the porcine high-affinity immunoglobulin G Fc receptor ( FcgammaRI). Paper-12266672. FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features. Paper-9348359. It was suggested that Fc-receptor or Ia-like antigen in human has a close relation with beta2-microglobulin. Paper-3122300. Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils. Paper-7719807. Thus, separate receptors mediate these stimulations, and Fc receptor cross-linkage is required for IL-4 production. Paper-4888. By inhibition studies it is demonstrated that mouse IgG1, IgG2a, and IgG2b MC bind to the same Fc receptor. Paper-5149418. In these cases, the ratio of B cell expressing low-affinity Fc receptor for IgE ( Fc epsilon RII) also decreased. Paper-7173441. There were also some spleen cells reacting with ABS even after depletion of C3- and/or Fc-receptor-bearing cells. Paper-3456180. The FcR aglutinated erythrocytes that were coated with both IgG2b and IgG2a that did not otherwise hemagglutinate. Paper-3611922. FcRn is an Fc receptor that structurally resembles the major histocompatibility complex class I molecule. Paper-562730. This inhibition was not caused by direct suppressive effect of Ly-5 antibody or Fc receptor-mediated negative signaling. Paper-5169593. This inhibition by immune complexes appears to be mediated through the monocyte Fc receptor for mouse IgG1. Paper-4763260. The precipitating, C1q-binding, complement-activating and Fc receptor binding properties of these complexes were compared. Paper-4720703. Opposing effects of glucocorticoids on interferon-gamma- induced murine macrophage Fc receptor and Ia antigen expression. Paper-4865388. Stoichiometry of the interaction between the major histocompatibility complex-related Fc receptor and its Fc ligand. Paper-1970882. We show here that FcgammaRIIB, a low-affinity immunoglobulin G Fc receptor, and CD3 are involved in cerebellar functions. Paper-13320242. Exaggerated Neointima Formation in Human C-Reactive Protein Transgenic Mice Is IgG Fc Receptor Type I (Fc{gamma}RI)-Dependent. Paper-12687496. Purified rabbit anti- M-CSF IgG, but not normal rabbit IgG, inhibited the M-CSF- mediated Fc receptor enhancement. Paper-5489802. Murine B-cell stimulatory factor 1 ( interleukin 4) increases expression of the Fc receptor for IgE on mouse B cells. Paper-5475570. Specific subclasses of immunoglobulins ( IgG1 and IgG2b) bound to an Fc receptor on the surface of these macrophages. Paper-5274943. We conclude that Lyt-2+ T cells are triggered to IL 2 reactivity by Fc receptor-mediated presentation of RaMB antibodies. Paper-4936187. These data indicate that Fc receptor binding of IgG2b results from the concerted action of membrane lipid and protein. Paper-3572440. Localization of the site of the murine IgG1 molecule that is involved in binding to the murine intestinal Fc receptor. Paper-134404. Fc-receptor for mouse IgG1 ( Fc gamma RII) and antibody-mediated cell clearance in patients treated with Leu2a antibody. Paper-6250130. Requirement for a beta 2-microglobulin- associated Fc receptor for acquisition of maternal IgG by fetal and neonatal mice. Paper-243048. Subpopulations of small cells express low levels of c-kit, FcR, and MHC type II, and only a 20% subpopulation is weakly endocytic. Paper-8490451. Resident peritoneal macrophages were incubated with M-CSF for 48-72 hr and analysed for Fc receptor and Ia antigen expression. Paper-5489802. Immunological properties of Fc receptor on lymphocytes. 4. Fc receptor of Con A induced suppressor and helper T cells. Paper-3070469. Innate stimuli accentuate end-organ damage by nephrotoxic antibodies via Fc receptor and TLR stimulation and IL-1/ TNF-alpha production. Paper-10601613. Expression and crystallization of a soluble and functional form of an Fc receptor related to class I histocompatibility molecules. Paper-7264126. The same effect could also be achieved through site-directed mutagenesis of the FcR binding site in the IgG1 H chain. Paper-1832725. We have used monoclonal IgG3 anti-SRBC to identify a third Fc receptor on mouse macrophages which binds IgG3 uniquely. Paper-3803048. Toward understanding the sites of FcRn function, we have generated a mouse strain in which this Fc receptor can be conditionally deleted. Paper-13631615. In vitro, this pathway can be interrupted by coligation to FcgammaRIIB, an IgG Fc receptor containing an inhibitory motif (ITIM). Paper-1731894. It is shown that the Fc receptor for IgG on lymph node cells recognizes IgG molecules of mouse IgG1, IgG2a and IgG2b subclasses. Paper-2644450. Expression of the Fc-receptor for IgE ( Fc epsilon RII, CD23) on alveolar macrophages in extrinsic allergic alveolitis. Paper-6828096. Alloantisera to H-2K, H-2D, and Ia antigens markedly inhibited the binding of EA but not FITC-IgG by the B cell Fc receptor. Paper-2483879. The increase in intracellular free calcium associated with IgG gamma 2b/gamma 1 Fc receptor-ligand interactions: role in phagocytosis. Paper-4766807. Thus, talin and F-actin undergo dynamic and coordinate changes in their cytoplasmic location during Fc receptor-mediated phagocytosis. Paper-22778. Flow cytometry and Fc receptor- blocking experiments showed that CD16(+) cells were essential for IL-2-enhanced ADCC. Paper-1710176. The invading phagocytic cell population was identified as Fc receptor-positive, Mac-1-positive macrophages by immunocytochemistry. Paper-6293458. Additional Fc receptor-bearing cells were revealed in bursa, spleen and bone marrow lymphocytes after neuraminidase treatment. Paper-2974503. These results indicate that both the HA and the NA induce antibodies that enhance uptake of virus by Fc receptor bearing cells. Paper-7149748. Stimulation of helper cells by either dendritic cells or Ia+ Fc receptor-positive cells resulted in the production of interleukin 2. Paper-4063264. They do not resemble mature DC because they express low levels of MHC type II and CD86 molecules, as well as c-kit and Fc receptor ( FcR). Paper-8490451. Human CD32B ( FcgammaRIIB), the low-affinity inhibitory receptor for IgG, is the predominant Fc receptor ( FcR) present on B cells. Paper-12237493. Mouse anti-human CD3 (T3) antibodies can induce T cell proliferation in the presence of Fc receptor (FcR)-bearing accessory cells. Paper-5724602. Mouse macrophage Fc receptor for IgG gamma 2b/gamma 1 in artificial and plasma membrane vesicles functions as a ligand-dependent ionophore. Paper-4464826. The findings of this study provide additional evidence that induction of Fc receptor and Ia antigen by IFN-gamma occurs by different mechanisms. Paper-4865388. We have studied the distribution of talin in J774 cells and mouse peritoneal macrophages undergoing Fc receptor-mediated phagocytosis. Paper-22778. Maturation would take place between days 6-8 as long as the cultures were depleted of Fc-receptor-bearing cells, or if TNF-alpha were added. Paper-1025817. An interferon-gamma activation sequence mediates the transcriptional regulation of the IgG Fc receptor type IC gene by interferon-gamma. Paper-368330. An antibody against mouse Fc receptor (2.4G2) blocked the trapping but antibodies against mouse complement receptor (8C12, Mac-1 and 7G6) did not. Paper-7670844. These endogenous phagocytes were identified as proliferating resident monocytes and were positive for the Fc receptor and Mac-1 markers. Paper-6293458. The effect on cell numbers in vivo also depended on Fc receptor binding because reduced expansion was observed in FcRgamma(-/-) mice. Paper-12725085. Effects of receptor dimerization on the interaction between the class I major histocompatibility complex-related Fc receptor and IgG. Paper-418949. Regulation of macrophage Fc receptor (Fc gamma R)- mediated phagocytic function by histidine-rich glycoprotein ( HRG) was investigated. Paper-7471719. The fractions that contained the MGI did not induce FcR on bone marrow cells, while the fractions rich in FcRI did not induce colony formation. Paper-4000021. The complete sequence of the murine low affinity Fc receptor for IgE ( Fc epsilon RII), including the 5' and 3' flanking sequences, is reported. Paper-7056191. They present at their surface, besides the Mac-1 antigen and Fc-receptor, a mannose receptor which was characterized for its binding properties. Paper-6023946. Interferon-gamma treatment impairs Fc receptor type II-mediated phagocytosis of human macrophages by a post-receptor-binding mechanism. Paper-6924001. Effects of inhibitors of C1q biosynthesis on macrophage Fc receptor subclass-mediated antibody-dependent cellular cytotoxicity and phagocytosis. Paper-5481624. Microglia that form in op/op neopallial cell cultures, in the presence of CSF-1, are capable of Fc-receptor-mediated phagocytosis. Paper-294562. Occasional ALS-positive and one-third of the Fc receptor-bearing and phagocytic cells also separated in fractions 7 to 10 of the isokinetic gradient. Paper-3019823. Activation mediated by RP105 but not CD40 makes normal B cells susceptible to anti-IgM-induced apoptosis: a role for Fc receptor coligation. Paper-602800. Fc-receptor cross- linking induces rapid secretion of tumor necrosis factor ( cachectin) by human peripheral blood monocytes. Paper-5829496. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. Paper-12316649. Statin inhibition of Fc receptor- mediated phagocytosis by macrophages is modulated by cell activation and cholesterol. Paper-10948149. A critical role for Syk protein tyrosine kinase in Fc receptor-mediated antigen presentation and induction of dendritic cell maturation. Paper-9723802. A fully penetrant immunological defect also mapped to this segment, which encodes the high-affinity Fc receptor for immunoglobulin G (IgG), Fc gamma RI. Paper-7730271. Degradation by macrophage elastase was limited to the heavy chain, resulting in products that did not compete for binding to the macrophage Fc receptor. Paper-4484557. It was demonstrated that IgG2b, when compared with IgG1, led to differential activation of dendritic cells (DC) through Fc receptor signalling. Paper-10893533. Similarly, these absorbed sera retained the capacity to block the Fc receptor of BN lymphocytes, and this effect was completely strain specific. Paper-2615248. In addition, our studies point towards TrkB-Fc or TrkC- Fc receptor bodies as useful tools to influence the survival of neuroblastoma cells. Paper-10212683. This Fc receptor was not detectable on monocytes from those individuals exhibiting no mitogenic responses to IgG1 anti-T3 monoclonal antibodies. Paper-4763260. In contrast to the expression of Fc receptor capacity, both basal and IFN-gamma-induced levels of Ia antigen expression were inhibited by glucocorticoids. Paper-4865388. Despite similar levels of expression in macrophages, SLP-76 is not required for Fc receptor for immunoglobulin G (IgG; FcgammaR)-mediated activation. Paper-10390756. However, no PCR products were obtained, even for proteins known to be expressed in high copy numbers in mast cells ( beta-actin and Fc receptor). Paper-112225. A decreasing gradient of C3b and Fc receptor-mediated phagocytosis was established in the following order: B10.BR, B10, C3H/Di and C3H.SW strains. Paper-7039677. We conclude that Fc receptor function is triggered through binding to each of the three epitopes of Fc gamma RI that we have defined. Paper-6495289. CD23, the low-affinity Fc receptor for IgE, is constitutively expressed on mature, naive B cells, but is lost following B cell activation. Paper-342792. The unique individual and polymorphic properties of the FcR/FcRH members indicate a remarkably diverse Fc receptor gene family with immunoregulatory function. Paper-9310142. These results indicate that 44.7b binds to an epitope on the IgE molecule which is within the binding site of the mast cell IgE Fc receptor ( FcERI). Paper-6194526. Lipoprotein lipase regulates Fc receptor-mediated phagocytosis by macrophages maintained in glucose-deficient medium. Paper-1120396. B-lymphocyte Fc receptor- associated non-H-2 antigens are determined by a single polymorphic locus which is linked to the Mls locus. Paper-2828337. Live-cell affinity receptor chromatography ( LARC) resulted in a partially nonredundant list of 288 proteins that were specific to the Fc receptor complex. Paper-12890700. We have earlier reported on a group A streptococcal strain, type M12, which upon serial mouse passage acquired IgG Fc-receptor activity but lost the M-antigen. Paper-3705092. A major objective of the present studies was to seek biochemical evidence for the production of the low affinity IgE Fc receptor ( CD23) by murine T cells. Paper-104235. The Fc receptor on B lymphocytes, Fc gamma RIIB (beta 1 isoform), helps to modulate B-cell activation triggered by the surface immunoglobulin complex. Paper-112822. Idd17 was localized to a 1.1-cM region between D3Mit26 and D3Mit40, proximal to Fcgr1, a candidate gene encoding the high affinity Fc receptor for IgG. Paper-1115162. T cell activation is thought to be triggered by CD3 cross- linking mediated by the Abs bridging T cells and Fc receptor-bearing cells. Paper-1176221. Importantly, Mac-1(-/-) phagocytes retained the capacity to bind tumor cells, implying that Mac-1 is essential during actual FcR-mediated cytotoxicity. Paper-9787337. The binding affinity of human IgG for its high affinity Fc receptor is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region. Paper-6918444. The present results demonstrate that this polymorphism is caused by polymorphism of an Fc receptor for mouse IgG1, present on human monocytes. Paper-4763260. Studies on Fc receptor function. II. Depressive effect of aggregated IgG2b on B lymphocyte activation by T-dependent and T-independent antigens. Paper-3702387. Here we show that SAP forms a ternary complex with the kinase Lyn and the inhibitory IgG Fc receptor FcgammaRIIB to regulate B cell proliferation and survival. Paper-13036022. This suppression of MIP-2 production by intact immunoglobulin treatment was blocked by a specific Fc receptor (Fc gamma III/II receptor) antibody pretreatment. Paper-10380305. Cell surface antigens ( Mac-1 and Ia) and Fc receptor capacity (as assessed by Fc-mediated phagocytosis) were examined as markers of macrophage differentiation. Paper-5081902. A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus. Paper-8007446. Defects in the inhibitory Fc receptor, FcgammaRIIB, have been shown to contribute to B cell activation and autoimmunity in several mouse models of SLE. Paper-12212611. However, in a murine model of ITP, the therapeutic effect of IVIg appears to be wholly dependent upon the expression of the inhibitory Fc receptor, Fc gamma RIIB. Paper-10786916. Most clones express Thy-1, Pgp-1, ICAM-1, HSA and B220 antigen, but are negative for LFA-1, CD2, Mel 14, Fc receptor, Mac-1, CD4 and CD8. Paper-117885. Results of this study indicated that CEF inhibits the PCA in rats, presumably by blocking the binding of heterocytotropic antibodies to Fc receptor of mast cells. Paper-3734948. The data support the concept of Fc/Ia identity, and they suggest that H-2K, H-2D, and the Fc receptor may be closely grouped on the membranes of B cells. Paper-2483879. The interaction of the intact biMAb with Fc receptor I ( Fc gamma RI) present on human leucocytes was not observed when the antibody was used as an F(ab')2 fragment. Paper-371586. Finally, we evaluated the relative importance of the Fc receptor versus the complement pathway in disposing antibody-opsonized DAF/ Crry-deficient erythrocytes. Paper-9281778. We show that ingestion of amastigotes appears to occur primarily through the FcR and CR3; however, additional receptors may also participate in the uptake of amastigotes. Paper-7684808. However, despite this loss, the residual Fc receptor-positive cells present following hemorrhage were capable of releasing enhanced levels of PGE2. Paper-8233941. A new photometric microassay for the quantitation of macrophage Fc receptor function. In vitro enzyme-containing immune complexes clearance ( EIC) assay. Paper-12044. In addition, B lymphocytes from thoracic duct lymph of athymic nude mice and a Thy-1-positive, FcR-positive thymoma served as control cell populations. Paper-2258442. Nevertheless, cells derived from PAM cultures in media containing IL-3 displayed a high degree of heterogeneity in terms of their Fc receptor-mediated phagocytic activity. Paper-6024557. We demonstrate the utility of this method by conjugating F(ab')(2) fragments of an anti-B7-2 antibody, and using this conjugate to assay B7-2 on Fc-receptor bearing cells. Paper-2129253. The structure responsible for beta2 microglobulin binding to the surface of cells is distinct from the Fc receptor specific for aggregated IgG. Paper-2379734. ALP inhibited the conversion of the leukocyte beta2 integrins into an active conformation upon Fc receptor stimulation of granulocytes. Paper-10343182. Inhibition experiments provided evidence for the involvement of a complement receptor ( CR3) and an Fc-receptor ( FCR) for IgG in the uptake of opsonized microparticles. Paper-5934297. Each Mab, complexed to NS1, bound to macrophage Fc receptor ( FcR) but only the IgG2a and IgG2b Mabs sensitized YF-infected cells to complement-mediated cytolysis. Paper-7708190. When incorporated into immune complexes, the modified antibody also retains Fc receptor recognition ability as determined by erythrocyte-antibody rosette inhibition assays. Paper-4938457. Immunoglobulin Fc receptor ( FcR) gamma subunit is a component of low affinity receptor for IgG, Fc gamma RIII, as well as high affinity receptor for IgE, Fc epsilon RI. Paper-822695. Tyrosine phosphorylation of the gamma subunit of Fc gamma receptors, p72syk, and paxillin during Fc receptor-mediated phagocytosis in macrophages. Paper-112239. IgG affinity purification from detergent lysates of surface radiolabeled U937 cells has yielded both a 40-Kd IgG-binding membrane protein ( p40) and the 72-Kd FcR protein. Paper-5145902. The Fc receptor on thymus-derived lymphocytes. IV. Inhibition of binding of antigen-antibody complexes to Fc receptor-positive T cells by anti-Ia sera. Paper-2861363. The response of platelets to these MoAbs was blocked by prior addition of MoAb IV.3 specific for the Fc gamma RII receptor, indicating that activation was Fc receptor mediated. Paper-7317789. Increase in the percentage of monocytes able to bind mouse IgG2a was detected by Fc receptor flow cytometry analysis 24 h after the first IFN gamma infusion. Paper-6547144. Chronic administration of dexamethasone results in Fc receptor up-regulation and inhibition of class I antigen expression on macrophages from MRL/ lpr autoimmune mice. Paper-1190245. Here we show that Mincle selectively associated with the Fc receptor common gamma-chain and activated macrophages to produce inflammatory cytokines and chemokines. Paper-12949257. It has recently been proposed that the CH2-CH3 interface also contains the principal binding site for an isoform of the low affinity IgG Fc receptor II ( Fc gamma RIIb). Paper-8497028. Fc receptor (FcR)-mediated phagocytosis requires activation of the Rho GTPases Cdc42 and Rac1, but how they are recruited to the FcR is unknown. Paper-10794353. The G3 mutant cell line and the XC hybrid cell line had macrophage-like characteristics, such as surface antigens, Fc receptor, C3 receptor, and lysosomal enzymes. Paper-24275. FcgammaRI requires both the intracellular domain of the alpha-chain and associated leukocyte Fc receptor ( FcR) gamma-chains for its biological function. Paper-10520478. Infection with Nippostrongylus brasiliensis or injection of anti-IgD antibodies markedly enhances Fc-receptor- mediated interleukin 4 production by non-B, non-T cells. Paper-9688. Both placental macrophages and cell lines show colony-stimulating factor 1-dependent growth, express Fc receptors, and can perform Fc-receptor-mediated phagocytosis. Paper-7566853. Macrophage (MØ) phagocytosis via the Fc receptor for immunoglobulin G (Fc gammaR) requires the spleen tyrosine kinase ( Syk) and serves an important antimicrobial function. Paper-12027563. Immunohistochemical detection of Fc receptor. I. Light microscopic demonstration of Fc receptor by using soluble immune complexes of peroxidase-antiperoxidase immunoglobulin G. Paper-2869737. As many or more lymphocytes lack membrane-incorporated Ig determinants but have an Fc receptor that binds IgG1 and IgG3 in normal serum maximally at 4degreeC. Paper-2382268. This has been achieved by targeting the activity of the Fc receptor, FcRn, which serves through its IgG salvage function to maintain and regulate IgG concentrations in the body. Paper-11476369. Basal levels of Fc receptor capacity and Mac-1 antigen were markedly influenced by exposure to CSF-1, and appear to be modulated by CSF-induced, macrophage-derived IFN. Paper-5081902. In addition, iodinated FcR bound to Sephadex beads coated with rabbit IgG, mouse IgG1, IgG2b, and IgG2a, but not to beads coated with mouse IgG3 or rabbit F(ab')2 fragments. Paper-3611922. In summary, this study documents Mac-1 to be required for FcR-mediated antimelanoma immunity in vivo and, furthermore, supports a role for neutrophils in melanoma rejection. Paper-9787337. The cytoplasmic domains of Ig-alpha and Ig-beta share a region of limited homology with each other and with components of the T cell antigen receptor and of the Fc receptor. Paper-179089. We have observed that the phagocytosis of Candida is mediated by a combination of lectin-like receptor-, Fc receptor-, and complement receptor-type 3 (CR3)-dependent processes. Paper-334241. Tumor necrosis factor-alpha induces increased hydrogen peroxide production and Fc receptor expression, but not increased Ia antigen expression by peritoneal macrophages. Paper-5533781. We show that phospholipase C (PLC) gamma2 is phosphorylated downstream of Src family kinases and Syk during integrin or Fc receptor-mediated activation of neutrophils. Paper-13670764. Expression of these markers is increased with IFN-gamma treatment, although some evidence suggests that the induction pathway for Fc receptor and Ia antigen expression may be dissociable. Paper-4865388. SC-1 cells which showed such K cell activity, however escaped from Fc receptor detection by erythrocyte antibody rosettes and FITC-conjugated aggregated human gamma-globulin binding. Paper-3730915. Tissue macrophages from BALB/c mice were IgG1/G2b Fc receptor ( FcR)+ and Ia- late in disease, whereas macrophages in C57BL/6 became FcR and Ia during healing. Paper-5825760. MGF-cultured MO were positive for latex phagocytosis, non-specific esterase, Fc-receptor expression, and could mediate antibody-dependent cell-mediated cytotoxicity. Paper-6254998. The segregation of alleles among mouse genetic recombinants positions ADPRP on mouse chromosome 1 between the complement receptor-related gene At-3 and the Fc receptor locus FcR. Paper-6157496. Detection of macrophages and the characterization of Fc receptor-bearing cells in the mouse decidua, placenta and yolk sac using the macrophage-specific monoclonal antibody F4/80. Paper-4985619. These results identify PLCgamma2 as a critical player of integrin and Fc receptor-mediated neutrophil functions and the neutrophil-mediated effector phase of autoimmune arthritis. Paper-13670764. Interleukin-4 ( IL-4) is known to be involved in both the in vivo IgE response and the elevated B cell IgE Fc receptor (Fc epsilon R11) expression seen after a parasite infection. Paper-6276178. This review discusses possible markers of scleroderma, including fibronectin gene mutations, major histocompatibility complex class II antigens, anti-Scl-70, and the Fc receptor. Paper-7076585. Soluble forms of Fc receptor also regulate antibody production by enhancing interleukin-4-induced IgE synthesis ( Fc epsilon RII) or inhibiting IgG synthesis (Fc gamma R). Paper-7642890. We find that a significant proportion of FcR positive cells in decidual, placental and yolk sac tissues are macrophages as defined by the expression of the macrophage marker, F4/80 antigen. Paper-4985619. Some forms of macrophage ADCC have been reported to be inhibited by serum immunoglobulin, which competes with monoclonal antibodies for binding to the high-affinity Fc receptor ( FcRI). Paper-26962. This receptor ( Fc gamma RI) has been partially characterized using mAb 32 which binds outside the Fc binding domain of the receptor, but nonetheless triggers Fc receptor-dependent functions. Paper-6495289. Antibodies to CD3 are potent immunosuppressants now generally applied as non Fc-receptor ( FcR) binding monoclonals (F(ab')2 fragments in mice and humanized Fc-mutated monoclonals in humans). Paper-10665783. This defect in Fc receptor capacity is completely overcome by treatment of macrophage monolayers with extremely low concentrations of a lymphokine-rich, Con A-stimulated spleen cells supernatant. Paper-4134447. To address the potential pathogenicity of human RA-associated Abs, we developed a passive transfer model involving mice deficient in the low-affinity inhibitory Fc receptor, FcgammaRIIB. Paper-10811110. We now report a novel model for GPS using mice deficient in a central regulatory receptor for immunoglobulin (Ig)G antibody expression and function, the type IIB Fc receptor for IgG ( FcgammaRIIB). Paper-2150613. We investigated the hypothesis that certain Fc receptor functions promote the rapid induction of elevated T helper type 1 ( Th1) response, which effectively clears chlamydiae. Paper-9809112. However, the expression level of the Fc receptor for immunoglobulin G (Fc gamma R) did not increase, rather IL-4 caused a slight but consistent decrease in the Fc gamma R level on the B cells. Paper-5472628. Another source of Fc receptor ligands, autoimmune MRL/Mp- lpr/ lpr mouse sera, unlike MRL/Mp-+/+ sera, also showed synergism with 3-deazaadenosine in the inhibition of AD phi. Paper-5562140. Matrix-associated transforming growth factor-beta1 primes mouse bone marrow-derived mast cells for increased high-affinity Fc receptor for immunoglobulin E-dependent eicosanoid biosynthesis. Paper-8499107. An autoimmune MRL/Mp-Ipr/Ipr mouse-derived monoclonal IgG antibody stimulates cytokine production in bone-marrow-derived cell line by cross- linking of a cell surface antigen and Fc receptor. Paper-8065800. Using FcRgamma(-/-) and C1q(-/-) mice, we could definitively establish that the demyelinating capacity of such autoAb in vivo relies entirely on complement activation and is FcR-independent. Paper-12348202. 0. In summary, the data suggest that we have isolated the Fc receptor of the yolk sac and that this receptor is structurally and functionally related to the Fc receptor of the neonatal intestine. Paper-6840568. Both M phi populations stained positively with antibodies F4/80 and 2.4G2 ( Fc receptor IgG1/2b), bore mannosyl/fucosyl receptors, and showed reactivity for acid phosphatase and nonspecific esterase I. Paper-4985168. Trauma-hemorrhage suppressed Kupffer cell phagocytosis by decreasing Fc receptor expression and Akt activation; however, it induced p38 MAPK activation and increased NF-kappaB activity. Paper-13675091. On the platelet surface, GPVI is present as a complex with the homodimeric Fc receptor y-chain ( FcRgamma with a possible stoichiometry of two GPVI molecules and one FcRgamma dimer). Paper-13501682. TGF-beta 1 is suppressive but only indirectly via Fc-receptor-bearing suppressive cells, presumably suppressive macrophages, while TNF-alpha enhances the final maturation of DC. Paper-1025817. Previously we described a monoclonal antibody (mAb 12-15) that reacted with murine Fc receptor proteins (beta 1, beta 2 and alpha) and an undefined molecule of 37 kDa (beta 3) on certain types of cells. Paper-6386858. Direct measurement of the weak interactions between a mouse Fc receptor ( Fc gamma RII) and IgG1 in the absence and presence of hapten: a total internal reflection fluorescence microscopy study. Paper-7370572. We recently reported the isolation of a rat monoclonal antibody designated 2.4G2 (9) that is directed against the mouse trypsin-resistant Fc receptor ( FcR) for IgG2b and IgG1 immune aggregates. Paper-3611922. The Fc receptor for murine IgG1 could be detected by a newly developed rosetting assay on monocytes from all individuals responsive to the mitogenic effect of IgG1 anti-T3 antibodies. Paper-4763260. The Fc receptor common gamma-chain ( FcRgamma) is a widely expressed adaptor bearing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. Paper-13578043. We have now extended these studies by quantitating FcR expression on monocytes and cell lines by a recently developed EA rosette assay, using the erythrocyte-associated pseudoperoxidase activity. Paper-5474393. Purified T-cell-derived as well as recombinant IL-4 was shown to increase the expression of the low-affinity Fc receptor for IgE (Fc epsilon R) on a majority of B lymphocytes in a 24-hr culture period. Paper-5475570. Furthermore, suppression was not limited to Fc receptor- mediated phagocytosis because binding and uptake of C3bi-opsonized SRBCs to CR3 receptors was also decreased following LPS treatment. Paper-7726118. This decreased expression was also observed on zeta chains associated with the low affinity Fc receptor for IgG found in tumor-infiltrating NK cells ( Fc gamma RIIIA alpha; CD16). Paper-7630642. Here we show that the calcium-promoted Ras inactivator ( CAPRI), a Ras GTPase-activating protein, functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. Paper-10794353. Improvements in the half-lives of two different immunocytokines were made by changing the isotype of the human heavy chain C region from IgG1 or IgG3 to those with reduced binding to FcR, e.g., IgG4. Paper-1832725. Based on the fact that GPVI is coupled to the Fc receptor (FcR)-gamma chain and thus should share homology with the FcR chains, the genes encoding human and mouse GPVI were identified. Paper-8380379. In contrast, when ICA was induced in knee joints of Fc receptor ( FcR) gamma-chain(-/-) C57BL/6 mice, which lack functional Fc gamma RI and RIII, inflammation and cartilage destruction were prevented. Paper-8552994. RaMB-induced IL 2 reactivity was found to require accessory cells which are Fc receptor positive, and clearly distinct from those required to induce T cell proliferation in mixed lymphocyte cultures. Paper-4936187. Macrophages plated on both IgG2a-and IgG2b-coated substrates showed reduced immunofluorescence staining by an anti-IgG2b Fc receptor ( FcR) Ab, 2.4G2 and reduced E(IgG2a) and E(IgG2b) binding. Paper-4975572. Maternal IgG from milk is transported across the intestinal epithelium of neonatal rats by an Fc receptor (FcRn) that comprises an alpha-chain similar to the class I Ag of the MHC and beta 2-microglobulin. Paper-106125. Thus MRL-lpr/ lpr mice display a selective defect in MPS Fc receptor function and may provide a valuable model for elucidating the etiology and importance of MPS dysfunction in immune complex deposition disease. Paper-4839785. We used a mouse mAb (MC-39) against the 45-54-kD component of the Fc receptor of the neonatal intestine to find an antigenically related protein that might function as an Fc receptor in fetal yolk sac. Paper-6840568. An allotypic form of the low affinity IgG Fc receptor Fc gamma RIIa ( CD32), termed low responder (LR) because of its weak reactivity with mouse (m) IgG1, interacts efficiently with human (h) IgG2. Paper-7300014. Aggregation of the high-affinity Fc receptor (FcepsilonRI) for immunoglobulin E (IgE) in MC/9 mouse mast cells stimulates the synthesis and secretion of tumor necrosis factor alpha ( TNF-alpha). Paper-1051603. The hemagglutinin (HA) and neuraminidase ( NA) of influenza A viruses induce antibodies which augment the uptake of influenza A virus by antigen presenting cells via Fc receptor entry. Paper-7149748. In contrast to the inductive effect produced by cyclic AMP elevating agents, 8 BrcGMP and PGF2 alpha were unable to reverse the increased Fc receptor expression produced by LPS and fetal calf sera. Paper-3471802. Addition of a number of specific ligands to the immunoglobulin gamma 2b/gamma 1 Fc receptor resulted in a transient increase in [Ca2+]i, the magnitude of which depended on the extent of receptor aggregation. Paper-4766807. Exogenous C1q reconstitutes resident but not inflammatory mouse peritoneal macrophages for Fc receptor-dependent cellular cytotoxicity and phagocytosis. Relationship to endogenous C1q availability. Paper-6338512. These results demonstrate that targeting lymphoma cells via CD30 to the myeloid high affinity Fc receptor for IgG and to the Fc receptor for IgA results in potent in vitro anti-tumor activity. Paper-8700059. To assess the role of Fc receptor engagement in mediation of the disease, TSLP transgenic mice were crossbred with mice deficient for immunoglobulin- binding receptor gamma IIb ( FcgammaRIIb). Paper-13126083. Because Fc receptor- mediated phox assembly was normal in both C5(-/-) and C5(+/+) macrophages, the defect in phox assembly around MTB phagosomes was specific to C5 deficiency. Paper-12234582. Further analysis revealed that both maximal phosphorylation of SHIP and its association with Shc require co-clustering with the Fc receptor for IgG ( Fc gamma RII) rather than stimulation of the BCR alone. Paper-755998. The synthesis and release of CSF-1 and MCP-1 by mesangial cells as a consequence of Fc receptor occupancy may be responsible for macrophage recruitment and activation at sites of immune-complex deposition. Paper-54391. CONCLUSIONS: The inhibition of Fc receptor- mediated phagocytosis of lovastatin is related to its effect on cholesterol biosynthesis rather than its effect on the formation of isoprenoids. Paper-10948149. Conversely, injection of tTA producing adenovirus into mice that were transgenic for a trkB/Fc fusion protein gene under tc promoter control resulted in swift expression of serum trkB/ Fc receptor-body. Paper-1732400. Interaction of Fc receptor ( CD16) ligands induces transcription of interleukin 2 receptor ( CD25) and lymphokine genes and expression of their products in human natural killer cells. Paper-5792541. The inhibitory effect of lovastatin on Fc receptor-mediated phagocytosis was prevented completely by addition of mevalonate, farnesyl pyrophosphate, LDL, or cholesterol to the culture medium. Paper-10948149. With this series of isotype variant antibodies we were able, in proliferation induction experiments, to confirm the Fc receptor polymorphism for murine IgG2a, IgG2b and IgG1 on human monocytes. Paper-5473561. Before flow cytometry, the cells were stained with fluorescein isothiocyanate-conjugated anti-mouse monoclonal antibodies to specific immune cell membrane markers (Mac1, Fc receptor ( FcR) or CD45). Paper-7842281. This was probably due to an increased expression of Fc receptors on monocytes or to the modulation of Fc receptor signaling pathways by signals originating from the binding of TNF-alpha to its receptors. Paper-8802199. Since M phi have been shown to synthesize C1q, the Fc-recognizing subcomponent of the first component of complement, evidence was provided that endogenous C1q can serve as an Fc receptor on M phi during secretion. Paper-4821662. The clearance of 125I-labelled IgG1 was strikingly more rapid in the mice lacking beta 2-microglobulin. beta 2-microglobulin-/- mice lack functional molecules of the MHC class I-related Fc receptor, FcRn. Paper-868526. Interferon failed to enhance expression of the antigen detected by T101 on target cells, but it did increase Fc receptor binding of T101 and other IgG2A and IgG3 murine proteins, but not IgG1 or IgG2B. Paper-5207121. PIR-A requires homodimeric Fc receptor common gamma chain, which harbors an immunoreceptor tyrosine-based activation motif, for its efficient cell surface expression and for the delivery of activation signaling. Paper-8907979. Furthermore, MMP-induced aggrecan neoepitopes, which were abundantly found in controls, were also absent in FcR gamma-/-. Nevertheless, latent MMPs were present in the cartilage matrix as seen in APMA-activated patellae. Paper-2202597. Fc receptor-triggered macrophages interacted by a contact dependent, but histocompatibility independent, mechanism with T lymphocytes, thereby signalling the lymphocytes to elaborate the active product. Paper-3437943. Because M phi have been shown to synthesize C1q, the Fc-recognizing subcomponent of the first component of complement, evidence was provided that endogeneous C1q can serve as an Fc receptor on M phi during secretion. Paper-4708530. Efficacy of drug delivery with liposomes directed both to the Fc receptor and to glycophorin A was not reduced by human IgG or soluble antiglycophorin A, but it was reduced twofold in the presence of both soluble ligands. Paper-4750637. The intraperitoneal immunization with SRBC leads to a prompt increase of FcR expression and of phagocytic and pinocytic activity in the A/J mice, while in the B10 strain the activity of macrophages remains unchanged. Paper-4367809. Further, these observations suggest that the beta2-microglobulin associated with H-2 could serve to link T cells with the Fc receptor of B cells during the inductive phase of antibody synthesis. Paper-2483879. Although recent studies suggest that interferons can increase the number of IgG Fc receptor ( FcR gamma) sites on mouse macrophages, direct assessment of similar effects on human mononuclear phagocytes is lacking. Paper-4297378. Maturation of bone marrow lymphocytes. III. Genesis of Fc receptor-bearing " null" cells and B lymphocytes subtypes defined by concomitant expression of surface IgM, Fc, and complement receptors. Paper-3420460. In contrast to B cell FcR which bound IgG1 preferentially, those on T cells bound both IgG1 and IgG2, raising the possibility that the FcR on T cell is distinct from that on B cell. Paper-2258442. The bupleuran 2IIb-induced up-regulation of FcR was also blocked by two structurally distinct calmodulin antagonists, trifluoperazine and N-(6-aminohexyl)-5-chloro-1-naphthalenesulphonamide hydrochloride. Paper-279293. J774 FcR was judged to be a glycoprotein based on the sensitivity of its isoelectric point to neuraminidase digestion, its labeling with galactose oxidase/NaB[3H4], and its binding to concanavalin A-Sepharose. Paper-3611922. In this study, it was discovered that 4N1-1 or its derivative peptide, 4N1K, induces rapid phosphorylation of the Fc receptor ( FcR) gamma chain, Syk, SLP-76, and phospholipase C gamma2 in human platelets. Paper-9097411. In human platelets and leukocytes, ABP directly links, respectively, the membrane glycoproteins GPIb and the high-affinity Fc receptor for IgG (Fc gamma IR) to cytoskeletal actin microfilaments. Paper-94477. The increase of mRNA for CSF-1 and MCP-1 was not reduced by either cytochalasin B or D, indicating that Fc receptor occupancy is sufficient for signaling and that phagocytosis is not required to elicit this response. Paper-54391. This study has localized Lp to a region of approximately 1.46 cM on mouse chromosome 1, flanked by the gene for the alpha chain of high-affinity Fc receptor for IgE (Fcer1 alpha) and a microsatellite repeat D1Mit113. Paper-286908. The inhibitory function of PIR-B is mediated via its cytoplasmic immunoreceptor tyrosine-based inhibitory motifs, whereas PIR-A pairs with the Fc receptor common gamma chain to form an activating receptor complex. Paper-2069946. With respect to the mechanism underlying defective macrophage adherence in EFA deficiency, no change in the expression of cell surface adherence molecules ( Fc receptor, Mac-1, or LFA-1) was noted with the deficiency state. Paper-6865226. Results demonstrate the SHIP is the predominant intracellular ligand for the phosphorylated Fc gamma RIIB1 ITIM, although the SHP-2 decoy exhibits some ability to bind Fc gamma RIIB1 and block Fc receptor function. Paper-2087639. Biochemical signal transmitted by Fc receptor for immunoglobulin G2a of a murine macrophage-like cell line, P388D1: mode of activation of adenylate cyclase mediated by immunoglobulin G2a binding proteins. Paper-5389901. ALT was associated with hemoconcentration, hypotension, and circulatory collapse; however, toxicity could be prevented by platelet-activating factor inhibitor, rat antibody to Fc receptor, or IgM before IgG1. Paper-1982141. In addition to the above proteins detected by anti-phosphotyrosine immunoblotting, the gamma subunit of FcRI and III was shown to undergo tyrosine phosphorylation during Fc receptor-mediated phagocytosis. Paper-112239. We investigated the cytolytic mechanism by CD4+ T cells in anti-CD3 mAb- induced redirected cytotoxicity against a murine Fc receptor-bearing mastocytoma (P815) transfected with either CD80 or CD137 ligand (CD137L). Paper-8847479. It may well be that the residual Fc receptor population represents a sub-population of cells which have been differentially primed for enhanced PGE2 release by the hypotensive insult.(ABSTRACT TRUNCATED AT 250 WORDS) Paper-8233941. The expression of cell surface proteins on monocytes, including HLA-DR, HLA-DQ, beta 2-microglobulin, and the Fc receptor, and serum interleukin-1 activity also were not significantly increased by the administration of TNF. Paper-6953583. Sequence comparisons demonstrate that Lyb-2 is homologous to the asialoglycoprotein receptor and to CD23, the B-cell-specific Fc receptor for IgE, both of which are oriented with their carboxyl termini external to the cell. Paper-6144667. The interaction of ligands with the mouse macrophage Fc receptor which binds IgG2b and IgG1 immune complexes ( FcR gamma 2b/gamma 1) triggers phagocytosis and secretion of various mediators of inflammation. Paper-4480247. By culturing with tunicamycin A1, an inhibitor of N-glycosylation, or by sialidase digestion, mouse monocytic cells P388D1 were induced to carry out Fc receptor-mediated phagocytosis of IgG-coated sheep red blood cells. Paper-7771616. The sequence of the heavy chain C region of mouse mutant IgG2a antibodies with reduced capacity for C1q binding but with retained ability for Fc receptor-mediated functions was determined by cDNA cloning and by mRNA sequencing. Paper-6394862. Based on these results, it was proposed that the cells have at least two types of Fc receptor ( FcR) for homologous IgG isotypes: FcR2 for IgG2 and FcR1.2 for both IgG2 and IgG1, and also that VIA2 IgG1 is anti-FcR1.2 antibody. Paper-5471480. BQ inhibited the broadest range of functions including release of H2O2, Fc receptor-mediated phagocytosis, interferon gamma priming for tumor cell cytolysis, and bacterial lipopolysaccharide ( LPS) triggering of cytolysis. Paper-5904809. A series of amino acid substitutions were engineered into the CH2 domain of IgG3 and IgG4 at sites considered potentially important to Fc receptor binding based on homology comparisons of binding and nonbinding IgG subclasses. Paper-6918444. These results suggest that bupleuran 2IIb induces the up-regulation of FcR on macrophages by a mechanism dependent on an increase in intracellular Ca2+ followed by activation of the calmodulin, but not by a PKC or PKA pathway. Paper-279293. Modification of these responses in the presence of three monoclonal antibodies (MAb), NIMP-R10 and M1/70, which bind to different epitopes of the mouse C3 receptor, and 2.4G2, which binds to the mouse Fc receptor, was investigated. Paper-5169346. Serum interleukin-2 receptor levels and neopterin secretion were enhanced significantly 24 hours after therapy (P = 0.002); enhancement of monocyte Fc receptor levels had borderline statistical significance (P = 0.07). Paper-7235262. The mean fluorescent intensity of monocytes positive for HLA-DR and Fc receptor expression also increased significantly in both groups, as did serum beta 2-microglobulin expression and indoleamine 2,3-dioxygenase activity. Paper-7674797. Fc-receptor- mediated attachment and ingestion of opsonized sheep erythrocytes (EA) by the macrophages of spleen and peritoneal cavity were studied during dengue virus type 2 (DV) infection of Swiss albino mice. Paper-4404350. These results suggest that the polymorphism in the mitogenic effect of these IgG1 antibodies is caused by polymorphism in monocyte function, possibly at the level of the Fc receptor that reacts with mouse IgG1. Paper-4278041. Antigen presentation by human monocytes was recently found to be enhanced in vitro through the high-affinity Fc receptor for IgG ( Fc gamma RI; CD64), which is exclusively present on myeloid cells. Paper-482384. The ALCL model was established by intravenous injection of karpas299 cells into nonobese diabetic/severe combined immuno-deficient ( SCID/NOD) wild-type or SCID/NOD Fc receptor common gamma chain-deficient ( FcRgamma(-/-)) mice. Paper-12058714. BALB/C cells consistently removed more anti-S. typhimurium antibodies than did CBA cells, whilst the quantities of Fc receptor-bearing cells were found to be similar in both strains when measured by the erythrocyte-antibody rosette technique. Paper-3695366. In conclusion, Apt4 antibody binds to GPIIb/IIIa complex and induces aggregation, requiring energy metabolism, calcium, ADP release and Fc portion of IgG to interact with Fc receptor, but independent of thromboxane A2 formation. Paper-92512. Macrophages were activated 7 days after the inoculation, as indicated by the enhanced expression of MHC class II, intercellular adhesion molecule-1 ( ICAM-1) and Fc receptor ( FcR), which have been known as their activation markers. Paper-121229. The immunoreceptor tyrosine-based inhibition motif (ITIM) is found in various membrane molecules such as CD22 and the low-affinity Fc receptor for IgG in B cells and the killer cell-inhibitory receptor and Ly-49 in NK cells. Paper-2102879. Culture of murine splenic B cells with interleukin 4 ( IL-4) caused the up-regulation of the lymphocyte Fc receptor for immunoglobulin E (IgE) (Fc epsilon R) over a similar dose range as required for Ia up-regulation. Paper-5472628. Effects of immunoglobulin structure on Fc receptor binding: a mouse myeloma variant immunoglobulin with a gamma 2b-gamma 2a hybrid heavy chain having a complete gamma 2a Fc region fails to bind to gamma 2a Fc receptors on mouse macrophages. Paper-4213826. It was shown that LFA-1 and the Fc receptor on T gamma cells did not comodulate and it is therefore concluded that Fc receptors and LFA-1 are independent membrane structures, both required for the killer cell activity of T gamma cells. Paper-4709009. In addition to its effect on Fc receptor function, 2.4G2 also had a small but significant inhibitory effect upon the clearance of 125I-labeled heat-aggregated HSA by the mononuclear phagocyte system both in intact and C5-deficient mice. Paper-4615580. Inhibition by Ly-5.1 antiserum appeared not to be due to competition for the Fc receptor ( FcR), since in mixing experiments 'third-party' thymus cells treated with Ly-5 antiserum did not inhibit the cytotoxic activity of untreated cells. Paper-5781060. Involvement of Lyn in the IgE-mediated immediate-type hypersensitivity is well documented, but the physiological significance of Lyn in IgG-dependent, type III low-affinity FcR for IgG (FcgammaRIII)-mediated responses is largely unknown. Paper-8724023. One of these genes is the microglia-associated triggering receptor expressed on myeloid cells ( TREM2) which enhances phagocytosis, but abrogates cytokine production as well as TLR and Fc receptor-mediated induction of TNF secretion. Paper-12973066. Suppressive B-cell factor (SBF) is elaborated by FcR gamma ( Fc receptor for IgG)-bearing small, resting B cells after the stimulation of immune complexes and is known to inhibit humoral immune responses by acting on resting B cells. Paper-5792392. We demonstrated previously that inhibition of AT1R protects against crescentic glomerular injury in Fc receptor-deficient mice (gamma(-/-)) with anti-glomerular basement membrane antibody-induced glomerulonephritis (anti-GBM GN). Paper-12770820. The expression of this FcR on cell lines correlates with their accessory function in IgG1 anti-CD3-induced T cell proliferation. mIgG2a can inhibit the rosetting of monocytes with erythrocytes sensitized with human IgG. Paper-5474393. The liposomes were conjugated with either nonspecific mouse IgG, which interacts with an Fc receptor, or with monoclonal anti-human glycophorin, which interacts simultaneously with an Fc receptor and human glycophorin in the cell membrane. Paper-4750637. In conclusion, TA99 enhances DNA vaccination against both the target antigen Tyrp1 and a distinct melanoma antigen gp100 in an Fc receptor-dependent mechanism, consistent with enhanced cross-presentation of tumor-derived antigen. Paper-13474810. These suppressor cells are Fc-receptor positive small lymphocytic cells lacking T-cell markers which arise following implantation, are localized at the implantation site, and block the action of IL-2 that stimulates NK and T effector cells. Paper-5470361. Regulation of immune complexes binding of macrophages by pectic polysaccharide from Bupleurum falcatum L.: pharmacological evidence for the requirement of intracellular calcium/ calmodulin on Fc receptor up-regulation by bupleuran 2IIb. Paper-279293. Immunological evaluation indicated that the presence of specific anti-chlamydial antibodies enhanced chlamydial antigen presentation for induction of a Th1 response by FcR+/+, but not FcRminus sign/minus sign, antigen-presenting cells. Paper-9391877. The tetravalent MAbs containing both the CH2 and CH3 domains and a chimeric recombinant divalent antibody bound similarly to Fc receptor, C1q, and mediate antibody-dependent cellular cytotoxicity equally well with human natural killer cells. Paper-10436547. We recently reported the isolation from a placental cDNA library of clones encoding the alpha chain of a human homologue of the major histocompatibility complex class I-related Fc receptor, the neonatal Fc receptor ( FcRn). Paper-624553. The specificity for the IgE Fc receptor was suggested by the high levels of inhibition of IgE rosettes formed by eosinophils after incubation with the purified IgM fraction of BB10, whereas other receptors (Fc gamma R, CR1) were not affected. Paper-5388084. Stimulation of the CD40 antigen on normal B cells by crosslinking of anti-CD40 mAbs via their Fc receptor using a Fc gamma RII(CD32)-transfected mouse fibroblast cell line (' CD40 system') results in activation and proliferation. Paper-556282. However, the disruption of a single gene, which encodes the gamma chain of the Fc receptor, was found to achieve this uncoupling in a spontaneous model of lupus nephritis, the New Zealand Black/ New Zealand White (NZB/NZW) mouse. Paper-1325224. We now show that a significant proportion of resident AMO possess an Fc receptor for IgA (14%) and this proportion increases to nearly 30% upon activation of the cell, coincident with an increase in release of plasminogen activator and phagocytic activity. Paper-4353266. In our recent previous studies, we have identified and purified a murine 17-kDa protein which diminishes the avidity of binding between IgE and CD23 (low-affinity Fc receptor for IgE) without decreasing the quantitative expression of the CD23. Paper-7156259. These results indicate that exocytosis of granule enzyme from LAK cells is triggered by stimulation of Fc receptor on LAK cells and that LAK CMC and LAK ADCC differ in their lytic mechanism in terms of the release of BLT esterase. Paper-7156881. We did functional genetic screens to identify IgG1 Fc domains with improved binding to the low-affinity activating Fc receptor CD16A (FcgammaRIIIA) and reduced binding to the low-affinity inhibitory Fc receptor, CD32B ( FcgammaRIIB). Paper-12496603. We investigated the mechanisms of entry of amastigotes of Leishmania major from two different sources into macrophages by comparing their use of the Fc receptor ( FcR), complement receptor type 3 ( CR3), and mannose-fucose receptor ( MFR). Paper-7684808. Differentiated HL-60 cells were considered to be mature macrophages as judged by the positivity of butyrate esterase activity, the acquisition of Fc receptor, and the increment in capacity of phagocytosis and nitroblue tetrazolium reduction. Paper-5737720. We tested the hypothesis that the depressed Kupffer cell phagocytic capacity following trauma-hemorrhage is enhanced by estrogen administration and this occurs due to maintenance of Fc receptor expression and cellular ATP content via the activation of Akt. Paper-13675091. The four necessary and sufficient elements for HITT in vivo were established in our mouse model (namely platelet factor 4 [ PF4], heparin, antibody to the heparin/ PF4 complex, and platelet Fc receptor for immunoglobulin G [FcgammaRIIa]). Paper-10633436. Evidence is presented that TLA do not exhibit Fc receptor properties, nor do they adsorb to murine leukemia virus antigens under the conditions of isolation for analysis on polyacrylamide gel electrophoresis (PAGE) in sodium dodecyl sulfate ( SDS). Paper-3242377. The existence of a molecule responsible for the induction of Fc receptor ( FcR) on bone marrow cells ( FcR inducer, FcRI) is demonstrated in conditioned media from the macrophage-like cell line WR19M.1 activated by bacterial lipopolysaccharides. Paper-4000021. Here we report that a monoclonal antibody (mAb) against the mouse TRAIL receptor, DR5, exhibited potent antitumor effects against TRAIL-sensitive tumor cells in vivo by recruiting Fc receptor-expressing innate immune cells, with no apparent systemic toxicity. Paper-10512663. Double-labeling studies with anti-Ia and a second monoclonal antibody revealed that all Langerhans cells expressed F4/80 (macrophage), Mac-1 (C3bi receptor), and 2.4G2 ( Fc receptor), as well as the thymus leukemia (TL) and heat-stable (M1.69/16) antigens. Paper-5115656. After crosslinking by anti-Ig reagents or by Fc receptor-bearing accessory cells, mAb D7 could induce IL-2 production from T cell hybridomas, and in the presence of PMA could trigger a vigorous proliferative response in resting peripheral T cells. Paper-5174342. Thus, the interaction between IgG and the complement system was unchanged both for pr/o IgG2 and pr/o IgG3, while the Fc-receptor- mediated antibody-dependent cellular cytotoxicity ( ADCC) was depressed to the same degree for both pr/o IgG2 and pr/o IgG3. Paper-7563769. The pharmacologic effect is mediated by a specific ligand-receptor interaction, since Fc receptor-positive cells are protected by an excess of unconjugated HSA and by the addition of a small amount of staphylococcal protein A, which binds to the Fc portion of IgG. Paper-4558135. In this study, we generated a double-mutant mouse strain deficient in both type II FcR for IgG ( FcgammaRIIB) and Lyn to exclude any involvement of inhibitory signaling by FcgammaRIIB, which otherwise downregulates FcgammaRIII-mediated cellular responses. Paper-8724023. A monoclonal antibody (MAb) with specificity for murine interferon-gamma ( IFN-gamma) was used as a probe for studying the effect of recombinant IFN-gamma (rIFN-gamma) on antiviral activity, Fc receptor expression, and Ia antigen induction in macrophages. Paper-5403406. Collagen-related peptide (CRP), a collagen homologue, induces platelet activation through a tyrosine kinase-dependent pathway, leading to sequential tyrosine phosphorylation of Fc receptor ( FcR) gamma-chain, Syk, and phospholipase C-gamma2. Paper-1758618. The Src family kinase Lyn initiates intracellular signal transduction by associating with a variety of immune receptors such as antigen receptor on B cells and high-affinity Fc receptor ( FcR) for immunoglobulin Ig(E) (FcepsilonRI) on mast cells. Paper-8724023. Injection of Fc receptor-negative cultured tumor cells into F1 hybrids, in which host cells could be distinguished from the tumor cells by anti-H2 sera, revealed that many or all of the Fc receptor-bearing cells in the resultant tumor were of host origin. Paper-2421743. These results suggest that tissue transglutaminase may have no significant role in bactericidal, tumoricidal, or tumoristatic function of macrophages; however, it might have some role in promoting the Fc-receptor-mediated phagocytic function of the macrophages. Paper-6359814. In vitro studies using mouse J774 FcR- expressing cells showed increased binding of interleukin 2-based immunocytokines, relative to their corresponding Abs, and that this was reversed in those fusion proteins made with IgG4 or mutated IgG1 H chains. Paper-1832725. A mouse macrophage-specific rat monoclonal antibody, F4/80, has been used to detect directly macrophages in short term cultures of mouse decidua, fetal placenta and yolk sac and to investigate the identity of Fc receptor ( FcR) bearing cells in these tissues. Paper-4985619. The Th2 cell-dependent activation of small resting T cells does not require the external cross-linkage of the anti-CD3 mAb via Fc receptor expressing cells or the secretion of lymphokines from the Th2 helper clones, but it is inhibitable by anti-LFA 1 antibody. Paper-31025. Specifically, we show that KIR ligation inhibits the Fc receptor (FcR)- induced tyrosine phosphorylation of the FcR- associated zeta signaling chain, the PTK ZAP-70, and phospholipase C gamma. Paper-833609. CD23, a low-affinity IgE Fc receptor, is not displayed on most resting T cells but its expression has been shown to be transiently induced in vivo and in vitro on some CD4+ T cells [1-4] and in vivo on CD8+ T cells by IgE-secreting hybridoma tumors [5]. Paper-275390. In fact, bone erosion and osteoporosis, but not inflammation, caused by aberrant TNF-alpha expression were ameliorated in mice deficient in Fc receptor common gamma subunit or beta(2)-microglobulin, in which the expression of PIR-As and PIR-A ligands is impaired, respectively. Paper-13325903. It was found that long-term established in vitro cell lines of the TA3/Ha SAD/2 and CAD/2 tumors were entirely negative for the Fc receptor, whereas injection of these cells led to the formation of tumors containing a high proportion of Fc receptor-bearing cells. Paper-2421743. The authors established that this was mediated by a Fc receptor- mediated process because 8G9 F(ab')2 fragments that lack the Fc portion of the IgG molecule were capable of inhibiting TNF-alpha secretion, but did not promote increased LPS uptake to the same degree. Paper-99487. From studies on the minimal structural requirement of IgG both for mediation and inhibition of EA rosettes using IgG and several well-defined fragments, it appeared that both the CH2 and the CH3 domain of Fc are needed for optimal interaction with the lymphocyte Fc receptor. Paper-3730847. An Fc receptor blockade with opsonized sheep erythrocytes abrogated LPS- mediated direct activation and triggering of interferon gamma-primed macrophages, but had no inhibitory effect on direct activation or triggering by CVF for nonspecific tumor cytotoxicity. Paper-5782304. In contrast, amastigotes isolated from mouse lesions bind with rapid, hyperbolic kinetics to COS cells expressing the Fc receptor or to peritoneal macrophages but with slow, sigmoid kinetics to COS cells expressing the CR3 or the mannose receptor. Paper-888220. Since FcgammaRIIB has been shown to act as a negative regulator, we speculate that in the aged mice Fc receptor- mediated mast cell function may be upregulated by a release from the negative regulation as a result of decreased FcgammaRIIB expression. Paper-2024980. Here we show that the Src-like protein-tyrosine kinase Fgr, which is specifically expressed in mature myelomonocytic cells, coimmunoprecipitates with IgG Fc receptor II ( Fc gamma RII), but not with Fc gamma RIII from detergent lysates of human peripheral neutrophils. Paper-7719807. The beta 2m dependence could not be explained by class I-dependent immunoregulatory cells (CD8+ cells, NK1.1+ T cells, or conventional NK+ cells) or by the transfer of maternal IgG into the prenatal/neonatal mouse made possible by the beta 2m-dependent Fc receptor (FcRn). Paper-1218726. Thymus-derived features were identified on the membrane of the neoplastic lymphocytes using the following cellsurface markers: Heterologous T-cell antigen, sheep erythrocyte receptor, surface immunoglobulin, complement receptor, Fc receptor and mouse erythrocyte receptor. Paper-2828724. To evaluate its signaling potential, we expressed constructs for chimeric molecules composed of the cytoplasmic region of FCRL5 and the extracellular and transmembrane regions of the IgG Fc receptor FcgammaRIIB in a B cell line lacking an endogenous Fc receptor. Paper-13276345. A survey of several cell surface components on the lymphoid tumor cells, obtained after transplantation of preleukemic cells, indicated that most of the tumor lines bore both the Thy-1.2 antigen (weak) and the Fc receptor, whereas the rest were positive only for the Fc receptor. Paper-2870017. One protein (17 kDa) modulates the low-affinity Fc receptor for IgE on lymphocytes (i.e., CD23); it decreases the binding avidity of IgE to CD23-bearing B cells without affecting quantitative expression of CD23 and is thus designated epsilon-receptor-modulating protein. Paper-6919052. Since schistosome-infected Fc receptor-deficient ( FcR gamma chain knockout) mice display the same exacerbated egg pathology as that observed in infected muMT mice, the B cell- dependent regulatory mechanism revealed by these experiments appears to require receptor-mediated cell triggering. Paper-1344546. In the present study, we have shown that cross-linking of GPVI by JAQ1 results in tyrosine phosphorylation of the same profile of proteins as that induced by collagen, including the Fc receptor ( FcR) gamma-chain, Syk, LAT, SLP-76, and phospholipase C gamma 2. Paper-8690092. Surface markers not specifically associated with the myeloid lineage such as the MHC class II antigens and the Fc-receptor; and surface markers normally associated with the B-cell and T-cell lineages such as B220, L3T4 and Thy1.2 are also found on these cell lines. Paper-6273413. Purified IFN increased Fc receptor-mediated phagocytosis in J774.2 cells, and in cAMP-responsive nonphagocytic variants but was without effect in cAMP-unresponsive nonphagocytic variants, in adenylate cyclase-deficient variants, and in cAMP-dependent protein kinase-deficient variants. Paper-4183931. Differences in the relative content of Fc receptor-bearing cells in ependymoblastoma and CT-2A tumors grown in vivo (8.3 and 16.8%, respectively) were proportional to differences in the relative content of NeuGc-containing gangliosides (25.5 and 45.1%) and GA1 ( 8.5 and 13.8%), respectively. Paper-806648. The phenotype was determined on the basis of the quantitative binding of monoclonal antibodies to cell-surface antigens (antigen F4/80, complement receptor III, Fc receptor II, Ia antigen, common leukocyte antigen, and Mac-2 and Mac-3 antigens) on individual mononuclear phagocytes. Paper-5600224. Given the high affinity of FcRI (the subtype I Fc receptor for IgE) for IgE monoclonal antibody (mAb), modification of T cells with chimeric FcRI in combination with tumor-specific IgE mAbs is potentially a powerful and effective strategy to specifically target T cells to tumor cells. Paper-12360936. Fc receptor involvement in arthritis has been evaluated, identifying pro-inflammatory and inhibitory Fc gamma receptor subtypes, and demonstrating a link between Fc gamma receptor expression, cytokine production, cartilage destruction, and mouse strain susceptibility to immune complex arthritis. Paper-9460013. We previously identified a novel Fc receptor for IgA and IgM, designated Fcalpha/mu receptor (Fcalpha/muR), whose gene is closely located at the polymeric immunoglobulin receptor (poly-IgR), also a receptor for IgA and IgM, in the Fc receptor gene cluster on the chromosome 1. Paper-12341381. We investigated the effect of a lymphokine termed 'suppressive B-cell factor' (SBF), which is produced by FcR gamma ( Fc receptor for IgG)-stimulated B cells or hybridoma TS4.44, and is known to suppress B-cell responses in vivo and in vitro by inhibiting their proliferation. Paper-5470236. These experiments suggest that alloantisera to the H-2 complex express at least part of their inhibitory properties by blocking the Fc receptor on B cells, and the data support the concept that certain Ia antigens and the Fc receptor are identical or closely associated. Paper-2260209. These results demonstrate that Fc-receptor-dependent mechanisms contribute substantially to the action of cytotoxic antibodies against tumors and indicate that an optimal antibody against tumors would bind preferentially to activation Fc receptors and minimally to the inhibitory partner FcgammaRIIB. Paper-10567899. The T cells used in these studies were Thy-1+, Lyt-1+, Lyt-2- and lacked Fc receptor for IgM, IgG and IgA, and the unprimed splenic B cells were selected by the fluorescence-activated cell sorter for their lack of expression of surface (s)IgG and by panning for their lack of expression of sIgA. Paper-5128122. The MC-39 cross-reactive protein and beta 2-microglobulin, a component of the intestinal Fc receptor, were copurified from detergent-solubilized yolk sac by an affinity purification that selected for proteins which, like the intestinal receptor, bound to IgG at pH 6.0 and eluted at pH 8. Paper-6840568. Although cross-linking of either DAP10- or DAP12- associated receptors has been shown to be sufficient to trigger NK cell- mediated cytotoxicity against Fc receptor-bearing cells, substantial synergy was observed in the induction of cytokine production when both receptors were engaged. Paper-8536990. This result has led to clinical trials, presently ongoing, in recent onset type 1 diabetic patients using non FcR binding monoclonal antibodies to CD3 that are well tolerated since they are devoid of the mitogenic activity that was a hallmark of first generation CD3 antibodies such as OKT3. Paper-10665783. C5 presentation by macrophages was enhanced in the presence of C5-specific antibody and augmented further if antigen was added in the form of particulate latex-antigen-antibody complexes indicating enhanced uptake via Fc receptor-mediated endocytosis or phagocytosis. Paper-7349601. Both forms of recombinant human D-factor were active on the murine myeloid leukemia cell line M1 in a dose- and time-dependent manner for the inhibition of [3H]thymidine incorporation, and also induced phagocytosis, Fc receptor expression, and prostaglandin E2 synthesis by M1 cells. Paper-6495627. All lines were found to be consistently Fc receptor-negative, as assayed by rosette formation with sheep erythrocytes coated with subhemagglutinating amounts of anti-sheep erythrocyte antibodies, or bovine erythrocytes heavily coated with non-hemagglutinating anti-bovine erythrocyte antibodies. Paper-2780819. Furthermore, pre-treating macrophages with annexin V was found to inhibit phagocytosis of apoptotic thymocytes and thymocytes on which PS expression was artificially induced, but did not inhibit phagocytosis of latex beads or Fc receptor-mediated phagocytosis of opsonized erythrocytes. Paper-8439668. During the production of Fc receptor (FcR)-bearing hybridomas it was observed with a particular monoclonal anti-sheep red blood cell antibody (anti-SRBC 1/5, IgG1) that the contamination with Mycoplasma arginini of in vitro cultured cell lines leads to an apparent FcR activity. Paper-4918878. Although the Src homology 2 domain-containing 5' inositol phosphatase (SHIP) is a well-known mediator of inhibitory signals after B cell antigen receptor (BCR) coaggregation with the low affinity Fc receptor, it is not known whether SHIP functions to inhibit signals after stimulation through the BCR alone. Paper-2204464. This study shows that aggregation of U937 cell high affinity IgG Fc receptor ( Fc gamma RI) results in the transient tyrosine phosphorylation of Fc gamma RI gamma-chain but not the phosphorylation of gamma-chains associated with nonaggregated IgA Fc receptors (Fc alpha R) on the same cells. Paper-544016. Other possible explanations are that IgG/antigen complexes are eliminated via Fc-receptor dependent phagocytosis or that the complexes inhibit B cell activation by co-crosslinking the B cell receptor for antigen and the inhibitory Fc-receptor, FcgammaRIIB, expressed by B cells. Paper-2017483. Mouse bone marrow-derived mast cells (BMMC) developed with IL-3 generate prostaglandin D2 ( PGD2) through the utilization of prostaglandin endoperoxide synthase (PGHS)-1 within several minutes of cross- linking the high affinity Fc receptor for IgE (Fc epsilon RI) by hapten-specific IgE and Ag. Paper-407700. Recent evidence validates a forgotten 40-year-old hypothesis: the MHC-related Fc receptor for IgG ( FcRn) protects albumin from intracellular catabolic degradation, as it does for IgG, accounting for the uniquely long half-lives of both molecules and explaining their direct concentration-catabolism relationships. Paper-12137675. CONCLUSIONS: These results suggest that IgG and IgM anti-LPS mAbs exert protective capacity by extracellular neutralization of LPS, while IgG Fc receptor- mediated cellular uptake also may serve to bypass macrophage activation and TNF-alpha secretion by promoting internalization and intracellular neutralization. Paper-99487. In order to characterize the Fc receptor for IgE ( Fc epsilon RII) on human eosinophils, we have compared the binding of human IgE myeloma protein to that of a monoclonal antibody (mAb BB10) directed against a common antigenic determinant of the Fc epsilon RII present on eosinophils, platelets and macrophages. Paper-5822829. Two assays were used: IgG1 and IgG2 EA rosettes to evaluate their Fc receptor-binding capacity, and IgG-mediated monocyte chemiluminescence to test their receptor-related activation since mouse anti-T cell antibodies binding to lymphocytes trigger monocyte chemiluminescence via their Fc receptor. Paper-5471868. To evaluate the feasibility of using a monoclonal anti-Fc receptor antibody to alter Fc receptor function in vivo, the disappearance of radiolabeled human serum albumin-rabbit anti-human serum albumin ( HSA-anti-HSA) complexes was studied in mice before and after the infusion of 2.4G2, a monoclonal antibody (developed by J. Unkeless). Paper-4615580. To overcome this problem and to study cells which expressed Fc gamma RI and only this Fc receptor, stable transfection of Chinese hamster ovary (CHO) cells ( Fc gamma RI-) with Fc gamma RI cDNA was performed thereby permitting biochemical characterization of Fc gamma RI in isolation from other Fc receptors. Paper-88971. Specifically, an increased number of macrophages was recovered from arthritic rats which spread readily in culture, exhibited enhanced Fc receptor-mediated phagocytosis, increased leucine aminopeptidase ectoenzyme activity, enhanced secretion of prostaglandin E2 and interleukin 1, and ability to lyse tumor cells spontaneously. Paper-5217612. We studied microglial Fc receptor ( FcR) activation with respect to the specific FcgammaR types involved and the downstream signaling events by using monoclonal antibody (MAb)-coated Cryptococcus neoformans immune complexes as the stimuli and macrophage inflammatory protein 1alpha ( MIP-1alpha) production as the final outcome. Paper-9535238. As a first step in generating a soluble MHC molecule that could function as an antigen-specific immunostimulant, the extracellular domains of the murine H-2Kb MHC class I molecule were fused to the constant domains of a murine IgG1 heavy chain, resulting in a divalent molecule with both a TCR-reactive and an Fc receptor (FcR)-reactive moiety. Paper-1796238. Neuraminidase digestion of the isolated proteins resulted in mobility shifts on polyacrylamide gel electrophoresis which were consistent with the interpretation that either the isolated proteins have considerably different sialic acid contents, or that removal of the sialic acid results in disaggregation of an Fc receptor molecule. Paper-2746756. epsilon receptor modulating protein (epsilon RMP) was identified and purified in our previous studies as a murine T cell-derived soluble 17-kDa chymotryptic serine protease which suppresses avidity of binding between IgE and CD23 (low affinity Fc receptor for IgE) without decreasing the quantitative expression of the CD23 molecule. Paper-7755916. These results indicate that the inhibitory signal that is transmitted through the FcR is not mediated by a global shutdown of tyrosine phosphorylation but is, rather, a selective mechanism involving localized changes in the interactions of adapter proteins and the enzymes Ship and phosphatidylinositol 3-kinase with the antigen receptor complex. Paper-930366. The mRNA expressions of nfat2 (nuclear factor of activated T cells 2) and oscar ( osteoclast-associated receptor) were enhanced only by SFs from patients with OA, whereas the mRNA expressions of dap12 (DNAX-activating protein 12) and fcrgamma ( Fc receptor common gamma subunit) were not affected by either of the two SF types. Paper-12478721. In the lungs of mice intratracheally inoculated with heat-killed C. neoformans, macrophages were activated, as indicated by augmented expression of MHC class II, intercellular adhesion molecule-1 ( ICAM-1) and Fc receptor ( FcR), and about two-thirds of macrophages were found to have ingested an average of 3.77 +/- 0.12 yeast cells per macrophage. Paper-261166. In particular, the ability of TCDD to mimic hallmark responses of B-cells to IL-4, such as upregulation of major histocompatibility complex (MHC) antigens of the class II type, increases in cell surface expression of the low affinity form of the Fc receptor for IgE ( CD23) and induction of immunoglobulin class switching, was tested. Paper-168089. EA rosette formation approached normal levels when masked H-2 but not Ia specificities were allowed to cap on the membranes of B cells. beta2-mu coated SRBC were bound by the Fc receptor, and high concentrations of soluble beta2-mu were found to moderately inhibit EA rosette formation while lower concentrations enhanced binding. Paper-2483879. Our results suggest that (i) at least two different pathogenic epitopes are implicated in autoimmune hemolytic anemia; and (ii) sequestration of agglutinated MRBC in spleens and livers and Fc receptor-dependent phagocytosis, but not complement-mediated hemolysis, are the major mechanisms for the development of autoimmune hemolytic anemia. Paper-6782576. CT did not affect the mRNA expression of dendritic cell-specific transmembrane protein, d2 isoform of vacuolar (H(+)) ATPase v(o) domain, a disintegrin and metalloproteinase domain 8 (ADAM8), ADAM12, DNAX-activating protein or Fc receptor common gamma chain suggested to be involved in fusion of mononucleated osteoclast progenitor cells. Paper-12605371. ISS-ODN and ISS-containing pDNA enhanced the expression of antigen presentation molecules (MHC class I and II), co-stimulatory molecules ( B7-1, B7-2 and CD40), cytokine receptors ( IFN-gamma receptor and IL-2 receptor), an adhesion molecule ( ICAM-1) and an Fc receptor (Fcgamma receptor) on murine B cells or bone marrow-derived macrophages. Paper-1974393. It thus appears that erythrophagocytosis of young and old erythrocytes from old donors and old erythrocytes from young donors are all mediated by a lectin-like receptor on the monocytes which recognizes beta-galactoside-like sugar moiety on the erythrocytes rather than by recognition of IgG on the erythrocyte and an Fc receptor on the macrophage. Paper-6926320. The phosphatase Src homology 2-containing inositol 5'-phosphatase 1 ( SHIP1) is known to exert inhibitory effects on Fc receptor ( FcR) signaling via its enzymatic activity on phosphatidylinositol 3-kinase ( PI3-K) products within many cells of the immune system, most notably mast cells, B cells, and monocytes. Paper-11239312. The inhibition of Cx43 using small interfering RNA or by obtaining macrophages from Cx43 heterozygous or knockout mice resulted in significantly impaired phagocytosis, while transfection of Cx43 into Fc-receptor expressing HeLa cells, which do not express endogenous Cx43, conferred the ability of these cells to undergo phagocytosis. Paper-13480838. These accession numbers are used for gene Fcr: . Important links ! iHOP - Information Hyperlinked over Proteins . Concept & Implementation by Robert Hoffmann.