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We conclude that TSG does not modulate an activity gradient of DPP. Paper-1152283.
Combinatorial signaling by Twisted Gastrulation and Decapentaplegic. Paper-1152283.
The interaction between TSG and DPP defines a novel type of combinatorial synergism. Paper-1152283.
In vitro association assays revealed a direct interaction of Tsg and TGF-beta proteins. Paper-13226410.
In addition, our data supports a role for Tsg in sensitizing the patterning mechanism to low levels of Dpp. Paper-9943602.
We demonstrate that Tsg and Sog play essential roles in transporting Dpp to the dorsal-most cells. Paper-10763882.
There are seven genes common to both deficiencies, including CG11582, which encodes a twisted gastrulation-like protein. Paper-12619829.
Signaling by these ligands is regulated at the extracellular level by the BMP binding proteins Sog and Tsg. Paper-10763882.
Thus, Tsg functions as an agonist synergizing with TGF-beta to inhibit T-cell activation. Paper-13226410.
crossveinless defines a new family of Twisted-gastrulation-like modulators of bone morphogenetic protein signalling. Paper-11144105.
In Drosophila, tsg acts in synergy with decapentaplegic ( dpp), a member of the TGF-beta family of secreted proteins. Paper-8995828.
Here we show that a second secreted protein, Twisted gastrulation ( Tsg), enhances the antagonistic activity of Sog/chordin. Paper-8719594.
Development of the vertebral morphogenetic field in the mouse: interactions between Crossveinless-2 and Twisted Gastrulation. Paper-13050905.
Facilitated transport of a Dpp/ Scw heterodimer by Sog/ Tsg leads to robust patterning of the Drosophila blastoderm embryo. Paper-10763882.
In accord with this result, coexpression of intact Sog and Tsg in developing wings generates a phenotype very similar to that of Supersog. Paper-8468998.
These data suggest that the developmentally regulated expression of Tsg may allow thymocytes to temporarily withdraw from inhibitory BMP signals. Paper-9216205.
Tsg can synergize with the BMP inhibitor chordin to block the BMP4-mediated inhibition of thymocyte proliferation and differentiation. Paper-9216205.
Twisted gastrulation ( Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes. Paper-13226410.
Genetic screen for regulators of ind expression identifies shrew as encoding a novel twisted gastrulation-like protein involved in Dpp signaling. Paper-12619829.
We also confirm that Tsg and Cv have similar biochemical activities: Sog/Cv complex binds a Dpp/ Gbb heterodimer with high affinity. Paper-11017153.
In this study, additional genetic and biochemical assays were developed to further probe the relationships between the Sog, Tsg, Tld and Dpp proteins. Paper-9943602.
Previous genetic and biochemical studies have revealed that the Sog, Tsg and Tld proteins modify Dpp activity at the post-transcriptional level. Paper-9943602.
Unlike the Decapentaplegic ( DPP) protein that is required to pattern the entire dorsal half of the embryo, TSG is needed only to specify the fate of the dorsal midline cells. Paper-1152283.
Instead, it functions in a permissive rather than instructive role to elaborate cell fates along the dorsal midline after peak levels of DPP activity have 'primed' cells to respond to TSG. Paper-1152283.
From these, 39 lines could be assigned to nine complementation groups: armadillo, brinker, folded gastrulation, giant, hindsight, Notch, runt, stardust and twisted gastrulation. Paper-8740815.
Physical properties of Tld, Sog, Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of the Drosophila embryo. Paper-9943602.
We show that Tsgs from different species are functionally equivalent, and conclude that Tsg is a conserved protein that functions with SOG/chordin to antagonize BMP signalling. Paper-8719594.
We show that the expression of Screw itself, and that of two regulators of Dpp/ Screw activity, Twisted-gastrulation and the Tolloid protease, is compromised in dCBP mutant embryos. Paper-10040760.
The crossveinless gene encodes a new member of the Twisted gastrulation family of BMP-binding proteins which, with Short gastrulation, promotes BMP signaling in the crossveins of the Drosophila wing. Paper-11017153.
In the early Drosophila embryo, Bone morphogenetic protein ( BMP) activity is positively and negatively regulated by the BMP- binding proteins Short gastrulation ( Sog) and Twisted gastrulation ( Tsg). Paper-11017153.
This in vivo processing of Sog can be duplicated in vitro by treating Sog with a combination of the metalloprotease Tolloid ( Tld) plus Twisted Gastrulation ( Tsg), another extracellular factor involved in Dpp signaling. Paper-8468998.
The evolutionarily conserved, secreted protein Twisted gastrulation ( Tsg) modulates morphogenetic effects of decapentaplegic ( dpp) and its orthologs, the bone morphogenetic proteins 2 and 4 (BMP2/4), in early Drosophila and vertebrate embryos. Paper-9216205.
Because the nature of their genetic interactions remained untested in the mouse, we generated a null allele for Cv2 which was crossed to Tsg and Chd mutants to obtain Cv2; Tsg and Cv2; Chd compound mutants. Paper-13050905.
Surprisingly, Tsg did not affect phosphorylation of the BMP-specific Smad1 but induced phosphorylation of the TGF-beta-specific Smad2 and mediated DNA binding on Smad3/4 consensus-binding sites, suggesting that it acted downstream of TGF-beta. Paper-13226410.
Mutations at the folded gastrulation (fog) and twisted gastrulation ( tsg) loci interfere with early morphogenetic movements in Drosophila melanogaster. fog embryos do not form a normal posterior midgut and although their germbands do elongate, they do not extend dorsally. Paper-4871142.
Subtractive hybridization identified Twisted gastrulation ( Tsg) as one of the genes suppressed by Tob. Tsg is a secreted protein that interacts with Drosophila decapentaplegic ( Dpp) and its vertebrate orthologs BMP2/4 and regulates morphogenetic effects in embryos. Paper-13226410.
The predominant view is that Sog and Tsg form a strong ternary complex with Dpp that prevents it from binding to its cognate receptors in lateral regions of the embryo, while in the dorsal-most cells Tld is proposed to process Sog and thereby liberate Dpp for signaling. Paper-9943602.
We propose that the strong Dpp concentration dependence exhibited by the processing reaction, together with movement of Dpp by Sog and Tsg protein can help explain how Tld activity is confined to the dorsal-most region of the embryo through formation of a spatially dependent positive and negative reinforcement loop. Paper-9943602.
Crossveinless-2 ( Cv2), Twisted Gastrulation ( Tsg) and Chordin ( Chd) are components of an extracellular biochemical pathway that regulates Bone Morphogenetic Protein ( BMP) activity during dorso-ventral patterning of Drosophila and Xenopus embryos, the formation of the fly wing, and mouse skeletogenesis. Paper-13050905.
These synonyms are used for gene tsg (twisted gastrulation): Tsg, RF32, Protein twisted gastrulation, l(1)tsg, l(1)RF32, l(1)11Ac, l(1)11Ab, dTsg, Dmel\CG1502, CG1502.
These accession numbers are used for gene tsg: Q9VYR6 (UNIPROT__AC), AAF48123 (NCBI_GENBANK__AC), AAC24234 (NCBI_GENBANK__AC).
tsg is a homologue of twsg1b (twisted gastrulation homolog 1b (Drosophila)) from Danio rerio.
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