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We have characterized two Drosophila POU genes designated dPOU-19 and dPOU-28. Paper-7197127.
Pdm and Castor close successive temporal identity windows in the NB3-1 lineage. Paper-13029690.
Pdm and Castor specify late-born motor neuron identity in the NB7-1 lineage. Paper-12231794.
DNA-dependent conversion of Oct-1 and Oct-2 into transcriptional repressors by Groucho/TLE. Paper-10805342.
This GMC-1 defect in miti- and pdm1- embryos can be rescued by the pdm1 or miti transgene. Paper-300204.
Overexpression of pdm1 or miti well after GMC-1 is formed results in the duplication of RP2 and/or sib cells. Paper-300204.
The miti-mere and pdm1 genes collaborate during specification of the RP2/sib lineage in Drosophila neurogenesis. Paper-300204.
We have isolated genomic and cDNA clones from three Drosophila POU domain genes, designated pdm-1, pdm-2, and Cf1a. Paper-6980983.
In GMC-1 of the RP2/sib lineage, Slit promotes asymmetric division by down regulating two POU proteins, Nubbin and Mitimere. Paper-9079571.
The mRNAs encode 601- and 475-amino acid deduced proteins; their POU domains are most related to those of the human OCT1 and OCT2. Paper-7197127.
The results show that pdm-1 and pdm-2 are coexpressed in an identified neural precursor and function redundantly to specify the fate of this cell. Paper-404980.
Upregulation of Mitimere and Nubbin acts through cyclin E to confer self-renewing asymmetric division potential to neural precursor cells. Paper-10210129.
Embryonic neuroblasts sequentially express Hunchback, Krüppel, Pdm1/ Pdm2 ( Pdm), and Castor ( Cas) transcription factors. Paper-12231794.
We show that deletion of pdm1 causes a partially penetrant GMC-1 defect, while deletion of both miti and pdm1 results in a fully penetrant defect. Paper-300204.
It shares sequence similarity with just the POU domain region of pdm-1, but shares extensive sequence similarity with the largest exon of pdm-2. Paper-235000.
These POU domain genes, pdm-1 and pdm-2, are expressed at high levels during early embryogenesis and at lower levels throughout the rest of development. Paper-6885102.
Hunchback and Krüppel specify early-born temporal identity, but the role of Pdm and Cas in specifying temporal identity has never been addressed. Paper-12231794.
Here, we identify neuronal birth-order and molecular markers within the NB3-1 cell lineage, and then use this lineage to assay Pdm and Castor function. Paper-13029690.
The closely linked pdm-1 and pdm-2 genes of Drosophila are expressed in complex patterns that suggest diverse roles in segmentation and nervous system development. Paper-235000.
In the horseshoe crab, a primitively aquatic chelicerate, pdm/ nubbin is specifically expressed in opisthosomal appendages that give rise to respiratory organs called book gills. Paper-9629536.
A recent report details the roles that two genes, pdm-1 and pdm-2, play within an identified neural stem cell lineage in the Drosophila embryonic central nervous system. Paper-404980.
Our results provide a new neuroblast lineage for investigating temporal identity and reveal the importance of Pdm and Cas as timing factors that close temporal identity windows. Paper-13029690.
Dimerization of Oct-1 and Oct-2 on palindromic response elements results in the conformational dependent inclusion or exclusion of the transcriptional coactivator OBF-1. Paper-10805342.
In this paper, we demonstrate that Oct-1 and Oct-2 can function as transcriptional repressors by recruiting and physically interacting with members of the Grg/TLE family of corepressors. Paper-10805342.
The closely linked POU domain genes pdm-1 and pdm-2 are first expressed early during cellularization in the presumptive abdomen in a broad domain that soon resolves into two stripes. Paper-7709086.
We have characterized two genes from Drosophila melanogaster that encode proteins with POU domains showing a high degree of identity with the human Oct-1 and Oct-2 transcription factors. Paper-6885102.
We examine the expression of two developmental genes, pdm/ nubbin and apterous, that participate in the specification of insects' wings and are expressed in particular crustacean epipods/gills. Paper-9629536.
Hunchback and Kruppel specify early temporal identity in two posterior neuroblast lineages (NB7-1 and NB7-3), whereas Pdm and Castor specify late neuronal identity in the NB7-1 lineage. Paper-13029690.
In mutant animals where both pdm-1 and pdm-2 functions are removed, GMC4-2a fails to express markers consistent with a GMC4-2a identity and no mature ( Eve protein expressing) RP2 neurons are produced. Paper-237593.
In later stage embryos, both pdm-1 and pdm-2 are expressed in selected neuroblasts in the ventral nervous system, with higher levels in the three thoracic segments and lower levels in the abdominal segments. Paper-6885102.
We have also identified the cells in the dorsal and lateral clusters of the peripheral nervous system that express pdm-1 and pdm-2, and show that some of these cells derive from lineages that require BX-C functions. Paper-6885102.
The spatial expression patterns of the pdm-2 and Cf1a genes show that they probably play multiple roles during development: an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system. Paper-6980983.
We have investigated (i) the role of pdm1, a Drosophila POU gene, during the elaboration of the GMC-1-->RP2/sib lineage and (ii) the functional relationship between pdm1 and the closely linked second POU gene, miti-mere, in this lineage. Paper-300204.
Six clusters are enhancers of adjacent genes: giant, fushi tarazu, odd-skipped, nubbin, squeeze and pdm2; three drive expression in patterns unrelated to those of neighboring genes; the remaining 18 do not appear to have enhancer activity. Paper-10643274.
In Drosophila, embryonic neural progenitors (neuroblasts) sequentially express the transcription factors Hunchback, Kruppel, Pdm1/ Pdm2 ( Pdm) and Castor as they generate a stereotyped sequence of neuronal and glial progeny. Paper-13029690.
In accordance with a model of DNA induced cofactor assembly, and analogous to the recruitment of the OBF-1 coactivator, the different Grg/TLE members can discriminate between both Oct-1 and Oct-2, and the monomeric or dimeric nature of the POU/DNA complex. Paper-10805342.
Because Pdm and Castor have only been assayed in one lineage, it is unknown whether their function is restricted to neuronal identity in the NB7-1 lineage, or whether they function more broadly as late temporal identity genes in all neuroblast lineages. Paper-13029690.
Here we show that Pdm and Cas regulate late-born motor neuron identity within the NB7-1 lineage: Pdm specifies fourth-born U4 motor neuron identity, while Pdm/ Cas together specify fifth-born U5 motor neuron identity. Paper-12231794.
Most interestingly, three transcription factors belonging to the POU domain class of homeodomain proteins, Pdm1, Pdm2 and Dfr/Vvl were isolated as Dif-interacting partners, and subsequently verified as regulators of CecA1 expression in Drosophila cells. Paper-13105665.
In spiders (terrestrial chelicerates), pdm/ nubbin and apterous are expressed in successive segmental primordia that give rise to book lungs, lateral tubular tracheae, and spinnerets, novel structures that are used by spiders to breathe on land and to spin their webs. Paper-9629536.
We conclude that Hunchback and Kruppel specify the first and second temporal identities, an unknown factor specifies the third temporal identity, and Pdm and Castor are timing factors that close the second and third temporal identity windows in the NB3-1 lineage. Paper-13029690.
We conclude that Pdm and Cas specify late-born neuronal identity; that Pdm and Cas act combinatorially to specify a temporal identity distinct from either protein alone, and that Cas repression of pdm expression regulates the generation of neuronal diversity. Paper-12231794.
We show here that within the early part of the NB4-2 lineage, two closely linked and structurally related POU homeo domain genes, pdm-2 ( dPOU28) and pdm-1 ( dPOU19), both encode proteins that accumulate to high levels only in the first GMC (GMC4-2a) and not in its progeny, the RP2 motoneuron. Paper-237593.
Our results from the genetic and developmental analysis of pdm-1 and pdm-2 demonstrate that these genes are not required for the birth of GMC4-2a; however, they are both involved in specifying the identity of GMC4-2a and, ultimately, in the genesis of RP2 neurons, with pdm-2 being the more dominant player in this process. Paper-237593.
These synonyms are used for gene pdm2 (POU domain protein 2): Protein didymous, POU domain protein 2, isoform A, POU-28, Pdm-2, pdm-2, Pdm2, Pdm, pdm, Oct-2, OCT2, Oct2, Miti-mere, miti, dPOU28/pdm-2, dPOU-28, dPOU28, dpou28, dOct2, Dmel\CG12287, dim, CG15487, CG15486, CG12287.
These accession numbers are used for gene pdm2: Q6NR41 (UNIPROT__AC), Q24430 (UNIPROT__AC), AAF53209 (NCBI_GENBANK__AC), AAA28481 (NCBI_GENBANK__AC).
pdm2 is a homologue of ceh-18 (Homeobox) from Caenorhabditis elegans.
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iHOP - Information Hyperlinked over Proteins .
Concept & Implementation by Robert Hoffmann.