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The Drosophila serotonin transporter ( dSERT) is normally expressed exclusively in serotonin ( 5-HT) neurons in the CNS. Paper-11400266.
These data suggest that a small number of neurons selectively express factor(s) required for 5-HT storage, and potentially for function of dSERT. Paper-11400266.
We find a surprising limitation on 5-HT storage following ectopic expression of dSERT and green fluorescence protein-tagged dSERT (GFP- dSERT). Paper-11400266.
Loss of robo2 or robo3 causes a loss of SerT expression in about half of neurons, and resembles the phenotype seen in mutants for the transcription factor eagle (eg). Paper-10208938.
When dSERT transcription is driven ectopically in the CNS, 5-HT is detectable only in 5-HT, dopamine ( DA), and a very limited number of additional neurons. Paper-11400266.
Finally, we show a direct relationship between robo2/3 and eg: robo2/3 mutants lose Eg expression in serotonergic neurons, and robo2 and eg interact genetically to regulate SerT expression. Paper-10208938.
Furthermore, this limitation is not due to gross mislocalization of dSERT, because cells lacking or containing 5-HT show similar levels and subcellular distribution of GFP- dSERT protein, nor is it due to lack of the vesicular transporter, dVMAT. Paper-11400266.
These synonyms are used for gene SerT (Serotonin transporter): Sodium-dependent serotonin transporter, SERT, Sert, dSERT1, dSERT, dSerT, dSert, DmSerT, Dmel\CG4545, Cocaine-sensitive serotonin transporter, CG4545, 5HT transporter, 5HTT.
These accession numbers are used for gene SerT: Q9W177 (UNIPROT__AC), Q23969 (UNIPROT__AC), AAF47200 (NCBI_GENBANK__AC), AAD10615 (NCBI_GENBANK__AC).
SerT is a homologue of slc6a4b (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4B) from Danio rerio.
SerT is a homologue of mod-5 (Modulation Of locomotion Defective) from Caenorhabditis elegans.
SerT is a homologue of LOC427700 (similar to serotonin transporter a) from Gallus gallus.
SerT is a homologue of AgaP_AGAP010621 (AGAP010621-PA) from Anopheles gambiae str. PEST.
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iHOP - Information Hyperlinked over Proteins .
Concept & Implementation by Robert Hoffmann.