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In Gli mutants, localization of SJ markers neurexin-IV, discs large, and coracle are disrupted. Paper-9732793.
Yurt, Coracle, Neurexin IV and the Na(+),K(+)-ATPase form a novel group of epithelial polarity proteins. Paper-13856140.
Drosophila neurexin IV interacts with Roundabout and is required for repulsive midline axon guidance. Paper-15063117.
We show that GFP-tagged Nrg and Nrx IV molecules exhibit very stable association with septate junctions in wild-type embryos. Paper-12900756.
Nrg-GFP is mislocalized to the baso-lateral membrane in nrx IV or cont null mutant embryos, and displays increased mobile fraction. Paper-12900756.
Coexpression of Nrx IV and Robo in mammalian cells confirms that these proteins retain the ability to interact in a heterologous system. Paper-15063117.
Similarly, Nrx IV-GFP becomes distributed to the baso-lateral membrane in null mutants of vari and cora, and its mobile fraction is strongly increased. Paper-12900756.
Genetic analyses indicate that Nrx-IV and Na(+),K(+)-ATPase act together with Cora in one pathway, whereas Yrt acts in a second redundant pathway. Paper-13856140.
Furthermore, Ggamma1 signaling is required for proper SJ protein localization, and loss of at least one SJ protein, Nrx-IV, induces cardiac lumen collapse. Paper-13089995.
Furthermore, we demonstrate that the extracellular region of Nrx IV is sufficient to rescue Robo localization and axon guidance phenotypes in nrx IV mutants. Paper-15063117.
We have characterized a novel member of the neurexin family, Neurexin IV ( NRX), which is localized to septate junctions (SJs) of epithelial and glial cells. Paper-830834.
At subsequent stages of development, DLT interacts with the apical determinant Crumbs (CRB) and the laterally localized protein Neurexin IV ( NRX IV). Paper-1804664.
We show that CONT, Neuroglian ( NRG) (Drosophila homolog of NF-155) and NRX IV are interdependent for their SJ localization and these proteins form a tripartite complex. Paper-10629339.
Mutations in dlt or double-stranded RNA interference lead to aberrant localization of CRB and NRX IV and cause a concomitant loss of epithelial cell polarity. Paper-1804664.
The loss of Vari, a MAGUK protein that interacts with the cytoplasmic tail of Nrx IV, has a stronger effect than the null mutation of nrx IV on the lateral mobility of Nrg-GFP. Paper-12900756.
Interestingly, the murine homologs of Neurexin IV, Contactin, and Neuroglian are expressed at the paranodal SJs and play a key role in axon-glial interactions of myelinated axons. Paper-11400378.
Varicose ( Vari) and Coracle ( Cora), that both interact with the cytoplasmic tail of Nrx IV, are scaffolding molecules required for the formation of septate junctions. Paper-12900756.
These CAMs are interdependent for their localization at septate junctions and e.g. null mutation of nrx IV or cont induces the mislocalization of Nrg to the baso-lateral membrane. Paper-12900756.
Together, our studies establish that Nrx IV is essential for proper Robo localization and identify Nrx IV as a novel interacting partner of the Slit/ Robo signaling pathway. Paper-15063117.
We also show that Neurexin IV, Contactin, and Neuroglian are coexpressed in the peripheral glial membranes and that these proteins exist as a complex in the Drosophila nervous system. Paper-11400378.
Cardial-pericardial cell adhesion also relies on the septate junction (SJ) proteins Neurexin-IV ( Nrx-IV), Sinuous, Coracle, and Nervana2, which together function in a common pathway with Ggamma1. Paper-13089995.
The stronger effect of vari by comparison with nrx IV null mutation supports the hypothesis that this scaffolding molecule may cross-link different types of CAMs and play a crucial role in stabilizing the strands of septate junctions. Paper-12900756.
Mutations in neurexin IV, contactin, and neuroglian result in the disruption of blood-nerve barrier function in the PNS, and ultrastructural analyses of the mutant embryonic peripheral nerves show loss of glial SJs. Paper-11400378.
In vivo biochemical studies reveal that Nrx IV associates with Robo, Slit, and Syndecan, and interactions between Robo and Slit, or Nrx IV and Slit, are affected in nrx IV and robo mutants, respectively. Paper-15063117.
Here we report that the Drosophila FERM proteins Yurt ( Yrt) and Coracle ( Cora) and the membrane proteins Neurexin IV ( Nrx-IV) and Na(+),K(+)-ATPase are a new group of functionally cooperating epithelial polarity proteins. Paper-13856140.
These synonyms are used for gene Nrx-IV (Neurexin IV): rsg23, Nx IV, nrx-IV, NRX IV, Nrx IV, nrx IV, NrxIV, nrxIV, NRX, Nrx, nrx, Neurexin-4, l(3)rsg23, l(3)68Ff, Dnrx, Dmel\CG6827, CT21123, CG6827.
These accession numbers are used for gene Nrx-IV: Q9VTU5 (UNIPROT__AC), CAA60383 (NCBI_GENBANK__AC), AAF49951 (NCBI_GENBANK__AC).
Nrx-IV is a homologue of nlr-1 (Neurexin Like receptor) from Caenorhabditis elegans.
Nrx-IV is a homologue of LOC559157 (contactin-associated protein-like 2-like) from Danio rerio.
Nrx-IV is a homologue of CNTNAP2 (contactin associated protein-like 2) from Pan troglodytes.
Nrx-IV is a homologue of CNTNAP2 (contactin associated protein-like 2) from Homo sapiens.
Nrx-IV is a homologue of CNTNAP2 (contactin associated protein-like 2) from Bos taurus.
Nrx-IV is a homologue of Cntnap2 (contactin associated protein-like 2) from Mus musculus.
Nrx-IV is a homologue of AgaP_AGAP007545 (AGAP007545-PB) from Anopheles gambiae str. PEST.
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