Click here for the function of janA.
Edit this page in Wiki Genes - janA or see Wiki Gene.
The jan A and sry beta genes are expressed throughout development in both males and females. Paper-189612.
The 5' end of the janB mRNA mapped within the 3' untranslated region of the janA transcribed sequence. Paper-6160018.
This supports the hypothesis that janA transcription interferes with the function of the janB cis-regulatory elements. Paper-6546165.
The tissue specificity of the expression of the janB gene is maintained when most of the janA coding and upstream sequences are deleted. Paper-6546165.
Together these data indicate that in spite of the physical proximity of the jan A and sry beta genes, their transcription is regulated by separate cis-acting sequences. Paper-189612.
Transcription of janB is restricted to this developmental process, whereas janA is ubiquitously transcribed in both the somatic and germinal tissues of males and females. Paper-6546165.
Activity of Sex-lethal is initiated early in females by chromosome-counting transcription factors, then reinforced by signaling through the Janus kinase pathway. Paper-13215598.
A restriction survey of an additional 28 lines of D. simulans revealed strong linkage disequilibrium over the janA- janB region and identified six more alleles matching the rare haplotype. Paper-8868731.
Our results show that sry beta cis-acting sequences are located in the (-117; +137) 5'-region of the gene and that jan A cis-regulatory sequences are included in the (-56; +151) 5'-domain of this gene. Paper-189612.
Expression of the lacZ reporter regulated by STAT92E binding sites can be detected throughout embryogenesis, and is responsive to the Janus Kinase hopscotch and the ligand upd. Paper-11489484.
Results showed that the testis-specific expression of the janB gene is mediated by a short DNA sequence (positions -174 to +107) which is located entirely within the last exon of the upstream janA gene. Paper-6546165.
It comprises two partially overlapping genes, janA and janB, which are transcribed in the same orientation; the start of transcription of janB, the downstream gene, is located in the 3' exonic region of janA. Paper-6546165.
In order to test the possibility that some cis-acting regulatory sequences are shared by the two genes, we carried out a deletion analysis of the jan A/ sry beta intergenic region in D. melanogaster using transgenic lacZ fusion genes. Paper-189612.
Sequence comparison of the jan A- sry beta intergenic region and 5'-transcribed domain of each gene between D. melanogaster and D. pseudoobscura reveals short stretches of conserved sequences that may correspond to cis-acting regulator elements. Paper-189612.
The most striking feature of this sample was that in a 1.7-kb region containing the janA and janB genes, 30 out of 31 segregating sites contained variants present only once in the sample, and 29 of these unique variants were found in the same allele. Paper-8868731.
Phylogenetic analysis based on protein-encoding sequences predicts a duplication pattern of janA --> janA janB --> janA janB ocn, with the latter event occurring after the divergence of the D. melanogaster and Drosophila obscura species groups. Paper-8828612.
A constitutive activation mutation of the Janus kinase Hopscotch (hopscotch(Tumorous-lethal); hop(Tum-l)) results in a leukemia-like over-proliferation of hemocytes and copious differentiation of lamellocytes during larval stages. Paper-12600671.
The Janus tyrosine kinase/signal transducer and activator of transcription ( JAK/ STAT) pathway represents one such signalling cascade whose evolutionarily conserved roles include cell proliferation and haematopoiesis. Paper-10807756.
Data obtained from genomic and cDNA sequencing and from a combination of S1 mapping and primer extension experiments indicated a very unusual organization of this locus, which appeared to be composed of two partially overlapping genes, designated janA and janB. Paper-6160018.
We report here that RacGAP50C corresponds to the tumbleweed (tum) gene previously identified based on its defects in dendrite development of sensory neurons [Gao, F. B., Brenman, J. E., Jan, L. Y. & Jan, Y. N. (1999) Genes Dev. 13, 2549-2561]. Paper-11126722.
Although the Janus kinase-signal transducer and activator of transcription ( JAK-STAT) signaling pathway is part of the antiviral response in arthropods such as Drosophila, here we show that white spot syndrome virus (WSSV) uses a shrimp STAT as a transcription factor to enhance viral gene expression in host cells. Paper-12428755.
Given the conservation of socs-like genes and their regulation as Janus Kinases/Signal Transducer and Activators Transcription ( JAK/ STAT) pathway targets, we suggest that increased expression within the testis stem cells indicates increased levels of JAK/ STAT signalling and a conserved role for pathway signalling in testis stem cell maintenance. Paper-13022492.
These synonyms are used for gene janA (janus A): Sex-regulated protein janus-A, janus, jan A, Jan, Dmel\CG7933, CG7933, BcDNA:AT12574.
These accession numbers are used for gene janA: Q8T475 (UNIPROT__AC), AAC34203 (NCBI_GENBANK__AC), AAC34202 (NCBI_GENBANK__AC), A4V3M6 (UNIPROT__AC).
janA is a homologue of PHPT1 (phosphohistidine phosphatase 1) from Homo sapiens.
janA is a homologue of PHPT1 (phosphohistidine phosphatase 1) from Bos taurus.
janA is a homologue of PHPT1 (phosphohistidine phosphatase 1) from Gallus gallus.
janA is a homologue of PHPT1 (phosphohistidine phosphatase 1) from Canis lupus familiaris.
janA is a homologue of Phpt1 (phosphohistidine phosphatase 1) from Mus musculus.
janA is a homologue of Phpt1 (phosphohistidine phosphatase 1) from Rattus norvegicus.
janA is a homologue of phpt1 (phosphohistidine phosphatase 1) from Danio rerio.
janA is a homologue of F36A2.8 (hypothetical protein) from Caenorhabditis elegans.
janA is a homologue of AgaP_AGAP002078 (AGAP002078-PA) from Anopheles gambiae str. PEST.
Important links !
iHOP - Information Hyperlinked over Proteins .
Concept & Implementation by Robert Hoffmann.