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Morpholino phenocopies of the bmp2b/swirl and bmp7/snailhouse mutations. Paper-8919159.
bmp2b and bmp4 are dispensable for zebrafish tooth development. Paper-15442673.
Expression of bmp2a and bmp2b in late-stage zebrafish median fin development. Paper-11415566.
This latter pattern of bmp2b expression in the ZS mirrors tetrapod bmp2 expression in developing joints. Paper-11415566.
The nieuwkoid/ dharma homeobox gene is essential for bmp2b repression in the zebrafish pregastrula. Paper-8342779.
Involvement of the sonic hedgehog, patched 1 and bmp2 genes in patterning of the zebrafish dermal fin rays. Paper-1643950.
Also, the dorsalized phenotype of bmp2b-mutant embryos can be rescued by exogenous Smad1, but not by Smad5. Paper-2054154.
This result is consistent with the observation that there is no gap between the expression domains of zbmp-2 and otx-2. Paper-1726090.
A constitutively active Alk8-TGFbeta-receptor can ectopically induce bmp2b and bmp4 and rescues the dorsalization of MZspg. Paper-12047657.
Here we show that in addition to bmp2b and bmp4 another family member, bmp6, is involved in fin regeneration. Paper-12296348.
They do not respond to injected bmp2b mRNA, indicating that Smad5 is absolutely essential for ventral development and Bmp2/7 signaling. Paper-9434240.
These observations suggest a role for shh, ptc1 and bmp2 in patterning of the dermoskeleton of developing and regenerating teleost fins. Paper-1643950.
Most importantly, Mm169(-/-) embryos display reducedbmp7 mRNA levels during blastula stages, when bmp2b and bmp7 mutants are still normal. Paper-9434240.
Lastly we observed a striking increased penetrance of the swirl/ bmp2b dominant dorsalized phenotype, when Chordin function is also absent. Paper-9440522.
This indicates that pou2 acts upstream of Alk8, a maternally provided receptor implicated in the activation of zygotic bmp2b and bmp4 transcription. Paper-12047657.
In the inner ears of zebrafish larvae, chsy1 is expressed similarly to the BMP inhibitor dan and in a complementary fashion to bmp2b. Paper-15542888.
We show that ved transcripts are ventrally restricted by BMP factors such as bmp2b, bmp7, smad5, and alk8, and by dorsal factors ( chd and gsc). Paper-10443865.
The zbmp-2-expressing domain and the neuroectoderm, marked by otx-2 expression, were complementary, suggesting that BMP has a short-range effect in vivo. Paper-1726090.
The requirement for pou2 to initiate bmp2b expression can therefore be bypassed by releasing the repressive function of Fgf signaling upon bmp2b transcription. Paper-12047657.
Using a genetic interference approach we further identify bmp2b and bmp5 as crucial components of the endodermal signals that induce epibranchial neurogenesis. Paper-11159040.
We found that the expression of bmp2b and bmp4, both expressed in the normal optic vesicle at the protrusion stage, are extremely upregulated in the otic vesicle of gallery. Paper-12596097.
Injection of bmp2b or smad5 mRNA into homozygous mutant swirl ( bmp2b(-/-)) embryos rescues the early patterning defects in these mutants and the fish survive to adulthood. Paper-13602467.
Additionally, both genes are expressed in neural and hemal arches and spines. bmp2a is strongly expressed in the lens; lens bmp2b expression is detected only weakly via RT-PCR. Paper-11415566.
In particular, increased levels of Bmp signalling in chordino gastrulae are associated with a markedly reduced her5 expression domain, that may be abolished by injecting bmp2b mRNA. Paper-9628546.
Several genes, including gata5, fgf8, bmp2b, one-eyed pinhead, and hand2, have been shown to be relevant to the patterning events that regulate myocardial differentiation. Paper-10696965.
Zebrafish wnt8; swr ( bmp2b) double mutants display a progressive loss of non-axial mesoderm and a concomitant expansion of axial mesoderm during gastrulation. Paper-11501659.
Conversely, injected mRNA encoding a constitutively active version of Alk8 can rescue the strong dorsalization of bmp2b/swirl and bmp7/snailhouse mutants, whereas smad5/somitabun mutant embryos do not respond. Paper-8711339.
Indeed, maternal pou2 function is necessary to initiate zygotic expression of ventrally expressed genes such as bmp2b and bmp4, and for proper activation of bmp7, vox, vent and eve1. Paper-12047657.
During development, nma expression is similar to that of bmp2b and bmp4, and analysis in the dorsalized and ventralized zebrafish mutants swirl and chordino indicates that nma is regulated by BMP signaling. Paper-8750731.
Further observations indicate that the bmp2 gene, in addition to being expressed in the same cells of the basal layer of the epidermis as shh, is also expressed in a subset of the ptc1-expressing cells of the blastema. Paper-1643950.
Further, we have shown that dlx3b and dlx4b function in a non-cell-autonomous manner for RB neuron development; dlx3b and dlx4b act to regulate bmp2b expression at the non-neural ectodermal border. Paper-10613723.
Notably, Bozozok appears to function by repressing transcription of target genes such as swr ( bmp2b) gene, and as such is the earliest acting repressor that the nascent dorsal axis is using to antagonize ventral influences. Paper-8773388.
The boz gene is activated in the organizer in response to beta-catenin signaling, and Boz protein has been demonstrated to contribute to organizer formation by repression of ventralizing genes, including bmp2b, vega1, and vega2. Paper-10190205.
A much stronger dorsalization, similar to that of bmp2b/swirl and bmp7/snailhouse mutants, however, is obtained by inhibiting both maternally and zygotically supplied alk8 gene products with morpholino antisense oligonucleotides. Paper-8711339.
Double mutant analyses and RNA injection experiments show that sbn and bmp2b interact and that sbn acts downstream of Bmp2b signaling to mediate Bmp2b autoregulation during early dorsoventral (D-V) pattern formation. Paper-1882735.
By analyzing genes whose expression is very sensitive to BMP signaling levels, we found that the absence of Ogon or Chordin antagonism did not increase the BMP activity remaining in swirl/ bmp2b or hypomorphic snailhouse/ bmp7 mutants. Paper-9440522.
Similar to the BMP antagonist chordino, we found that the BMP ligand mutants swirl/ bmp2b and snailhouse/ bmp7 are also epistatic to the putative BMP pathway antagonist, ogon, excluding a class of intracellular antagonists as candidates for ogon. Paper-9440522.
The dorsalized mutants swirl/ bmp2b, snailhouse/ bmp7, lost-a-fin/ alk8, and mini fin/ tolloid were each analyzed in double mutant combinations with the ventralized mutants chordino/ chordin and ogon, whose molecular nature is not known. Paper-9440522.
Gene co-expression during segmentation (5.5-6.5 mm SL) is similar between tetrapods and zebrafish: bmp2b, bmp4, chordin, and gdf5 in interradial mesenchyme and ZS; bapx1, col2a1, noggin3, and sox9a in chondrocytes. Paper-12588982.
Overexpression experiments of wild-type and chimeric Hex constructs indicate that Hex functions as a transcriptional repressor and its overexpression led to the downregulation of bmp2b and wnt8 expression and the expansion of chordin expression. Paper-8314650.
In the present study, we have used dorsalized swirl ( bmp2b) and ventralized chordino ( chordin) zebrafish mutants to investigate the effects of dorsoventral signalling on endoderm patterning and on the differentiation and positioning of its derivatives. Paper-9628546.
Knockdown of tsg1 combined with loss of function of the BMP agonist tolloid (mini fin) or heterozygosity for the ligand bmp2b (swirl) enhanced dorsalization, supporting a role for Tsg1 in specifying ventral cell fates as a BMP signaling agonist. Paper-10900199.
Zygotic laf/ alk8 mutants can be rescued by overexpression of the BMP signal transducer Smad5, but not the Bmp2b or Bmp7 ligands, consistent with the Laf/Alk8 receptor acting within a BMP signaling pathway, downstream of a Bmp2b/ Bmp7 signal. Paper-8711340.
Amputations of caudal fins immediately after the first branching point of the lepidotrichia, and global administration of all-trans-retinoic acid, two procedures known to cause fusion of adjacent rays, result in a transient decrease in the expression of shh, ptc1 and bmp2. Paper-1643950.
We used morpholino antisense oligonucleotides and mutant analysis in the zebrafish to reduce or eliminate the function of bmp2b and bmp4, two ligands known to be expressed in zebrafish teeth and whose mammalian orthologs are thought to play important roles in tooth development. Paper-15442673.
Although smad1, smad5, bmp2b, and bmp4 are all expressed during gastrulation and although all four proteins have ventralizing activities, they appear to play distinct roles during dorsoventral pattern formation. smad1 expression starts shortly before the onset of gastrulation. Paper-2054154.
Similar to the amphibian embryo, the key patterning functions of the fish dorsal organizer (i.e., dorsalization of mesoderm, ectoderm, and coordination of gastrulation movements) are performed by secreted molecules that antagonize the ventralizing activity of the swil ( zbmp-2) and zbmp-4 gene products expressed on the ventral side of the embryo. Paper-1651035.
These synonyms are used for gene bmp2b (bone morphogenetic protein 2b): zbmp-2, zbmp2, MGC92556, MGC136722, cb670, bmp2-4, bmp-2, bmp2.
These accession numbers are used for gene bmp2b: O57573 (UNIPROT__AC), O13108 (UNIPROT__AC), BC114256 (NCBI_GENBANK__AC), BC076076 (NCBI_GENBANK__AC).
bmp2b is a homologue of dpp (decapentaplegic) from Drosophila melanogaster.
bmp2b is a homologue of BMP2 (bone morphogenetic protein 2) from Homo sapiens.
bmp2b is a homologue of BMP2 (bone morphogenetic protein 2) from Pan troglodytes.
bmp2b is a homologue of BMP2 (bone morphogenetic protein 2) from Canis lupus familiaris.
bmp2b is a homologue of BMP2 (bone morphogenetic protein 2) from Bos taurus.
bmp2b is a homologue of BMP2 (bone morphogenetic protein 2) from Gallus gallus.
bmp2b is a homologue of Bmp2 (bone morphogenetic protein 2) from Mus musculus.
bmp2b is a homologue of Bmp2 (bone morphogenetic protein 2) from Rattus norvegicus.
bmp2b is a homologue of AgaP_AGAP007987 (AGAP007987-PA) from Anopheles gambiae str. PEST.
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