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Morpholino phenocopies of the bmp2b/swirl and bmp7/snailhouse mutations. Paper-8919159.
Expression of bmp2a and bmp2b in late-stage zebrafish median fin development. Paper-11415566.
An Oct-1 binding site mediates activation of the gata2 promoter by BMP signaling. Paper-10772815.
Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation. Paper-2149287.
Forced expression of gata5 in swr/ bmp2b and Zoep mutants restores robust nkx2.5 expression. Paper-8844342.
Lateral line primordia and neuromasts also express bmp2b, 4, follistatin, smad1, and smad5. Paper-10708252.
Based on their predicted amino acid sequences, these two clones were designated as zbmp-2 and zbmp-4. Paper-1002085.
The nieuwkoid/ dharma homeobox gene is essential for bmp2b repression in the zebrafish pregastrula. Paper-8342779.
Involvement of the sonic hedgehog, patched 1 and bmp2 genes in patterning of the zebrafish dermal fin rays. Paper-1643950.
Further, we show that the boz-mediated induction of hhex is independent of the Boz- mediated repression of bmp2b. Paper-10564339.
Also, the dorsalized phenotype of bmp2b-mutant embryos can be rescued by exogenous Smad1, but not by Smad5. Paper-2054154.
5. We show that both swr/ bmp2b and Zoep mutants exhibit defects in gata5 expression in the myocardial precursors. Paper-8844342.
Here we show that in addition to bmp2b and bmp4 another family member, bmp6, is involved in fin regeneration. Paper-12296348.
This result is consistent with the observation that there is no gap between the expression domains of zbmp-2 and otx-2. Paper-1726090.
We show that Radar ventralizes zebrafish embryos and induces the early expression of bmp2b and bmp4. Paper-8642066.
Ectopic expression of shh or bmp2 in the blastema-induced excess bone deposition and altered patterning of the regenerate. Paper-9165239.
A constitutively active Alk8-TGFbeta-receptor can ectopically induce bmp2b and bmp4 and rescues the dorsalization of MZspg. Paper-12047657.
They do not respond to injected bmp2b mRNA, indicating that Smad5 is absolutely essential for ventral development and Bmp2/7 signaling. Paper-9434240.
The extracellular BMP antagonist Chordin and other signals from the dorsal mesoderm play important roles in this process. Paper-11154534.
Most importantly, Mm169(-/-) embryos display reducedbmp7 mRNA levels during blastula stages, when bmp2b and bmp7 mutants are still normal. Paper-9434240.
Transcription regulation of the vegf gene by the BMP/Smad pathway in the angioblast of zebrafish embryos. Paper-10748732.
Activation of FGF signaling was also able to repress BMP transcription in the absence of protein synthesis. Paper-11154534.
However, each also regulates a remarkably distinct genetic program, with Smad5 uniquely regulating the BMP signaling pathway itself. Paper-12546149.
Lastly we observed a striking increased penetrance of the swirl/ bmp2b dominant dorsalized phenotype, when Chordin function is also absent. Paper-9440522.
The ventral ogon/ sizzled expression in the gastrula stage was reduced or absent in the swirl/ bmp2b mutants but expanded in the chordino mutants. Paper-9754808.
The CCN family member Wisp3, mutant in progressive pseudorheumatoid dysplasia, modulates BMP and Wnt signaling. Paper-12512366.
This indicates that pou2 acts upstream of Alk8, a maternally provided receptor implicated in the activation of zygotic bmp2b and bmp4 transcription. Paper-12047657.
The allele snh(st1) is a translocation deleting the bmp7 gene, while snh(ty68) displays a Val->Gly exhange in a conserved motif of the Bmp7 prodomain. Paper-2094640.
Bone patterning is altered in the regenerating zebrafish caudal fin after ectopic expression of sonic hedgehog and bmp2b or exposure to cyclopamine. Paper-9165239.
The zbmp-2-expressing domain and the neuroectoderm, marked by otx-2 expression, were complementary, suggesting that BMP has a short-range effect in vivo. Paper-1726090.
These data indicate that the BMP/Smad signaling pathway is involved in the regulation of zebrafish vegf transcription. Paper-10748732.
The requirement for pou2 to initiate bmp2b expression can therefore be bypassed by releasing the repressive function of Fgf signaling upon bmp2b transcription. Paper-12047657.
Using a genetic interference approach we further identify bmp2b and bmp5 as crucial components of the endodermal signals that induce epibranchial neurogenesis. Paper-11159040.
Moreover, swirl(tc300), a null mutation in bmp2b, is epistatic to ogo(m60) mutation, providing further evidence that ogo normally functions in a BMP-dependent manner. Paper-8296906.
Compensatory growth mechanisms regulated by BMP and FGF signaling mediate liver regeneration in zebrafish after partial hepatectomy. Paper-14024689.
Compensatory growth mechanisms regulated by BMP and FGF signaling mediate liver regeneration in zebrafish after partial hepatectomy. Paper-14024689.
We found that the expression of bmp2b and bmp4, both expressed in the normal optic vesicle at the protrusion stage, are extremely upregulated in the otic vesicle of gallery. Paper-12596097.
Our results suggest that specificity of BMP signaling output, with respect to hematopoiesis, can be explained by differential functions of Smad1 and Smad5. Paper-12546149.
We also found that zbmp-2 was induced cell autonomously within the transplanted cells in the host ectoderm, suggesting that BMP cannot influence even the neighboring cells. Paper-1726090.
Several genes, including gata5, fgf8, bmp2b, one-eyed pinhead, and hand2, have been shown to be relevant to the patterning events that regulate myocardial differentiation. Paper-10696965.
Additionally, both genes are expressed in neural and hemal arches and spines. bmp2a is strongly expressed in the lens; lens bmp2b expression is detected only weakly via RT-PCR. Paper-11415566.
In particular, increased levels of Bmp signalling in chordino gastrulae are associated with a markedly reduced her5 expression domain, that may be abolished by injecting bmp2b mRNA. Paper-9628546.
While Xenopus epidermal cytokeratin gene expression is activated by bone morphogenetic protein ( BMP) signaling, zebrafish cyt1 is not responsive to BMPs. Paper-10763110.
We observe a loss in neural crest progenitors in swirl/ bmp2b mutant embryos, while somitabun mutants display an opposite, dramatic expansion of the prospective neural crest. Paper-1508913.
Injection of bmp2b or smad5 mRNA into homozygous mutant swirl ( bmp2b(-/-)) embryos rescues the early patterning defects in these mutants and the fish survive to adulthood. Paper-13602467.
Zebrafish wnt8; swr ( bmp2b) double mutants display a progressive loss of non-axial mesoderm and a concomitant expansion of axial mesoderm during gastrulation. Paper-11501659.
The bone morphogenetic protein ( BMP) signaling pathway regulates multiple steps of hematopoiesis, mediated through receptor-regulated Smads, including Smad1 and Smad5. Paper-12546149.
The dorsalized mutant phenotypes of these genes can be rescued by overexpression of bmp4, bmp2b, an activated BMP type I receptor, and the downstream functioning Smad1 gene. Paper-1508913.
Expanded Zic1 expression in swirl and reduced expression in chordino as well as in bmp2 injected embryos suggest that BMP2 and its antagonists define the extent of zic1 expression in the neural plate. Paper-1972472.
Both swr/ bmp2b and oep mutants exhibit severe defects in myocardial development. swr/ bmp2b mutants exhibit reduced or absent expression of nkx2.5, an early marker of the myocardial precursors. Paper-8844342.
We observed that FGF signaling is required for chordin expression but that it also acts via other mechanisms to repress BMP transcription during late blastula stages. Paper-11154534.
We developed an assay in Xenopus embryos to analyze regulatory sequences of the zebrafish gata2 promoter that are necessary to mediate the response to BMP signaling during embryogenesis. Paper-10772815.
Double mutant snailhouse/ bmp7; swirl/ bmp2b embryos do not exhibit additional or stronger dorsalized phenotypes, indicating that these Bmp ligands do not function redundantly in early embryonic development. Paper-2149287.
Indeed, maternal pou2 function is necessary to initiate zygotic expression of ventrally expressed genes such as bmp2b and bmp4, and for proper activation of bmp7, vox, vent and eve1. Paper-12047657.
Activation of the gata2 gene during embryogenesis is dependent on the bone morphogenetic protein ( BMP) signaling pathway, but the mechanism for how signaling controls gene activity has not been defined. Paper-10772815.
Conversely, injected mRNA encoding a constitutively active version of Alk8 can rescue the strong dorsalization of bmp2b/swirl and bmp7/snailhouse mutants, whereas smad5/ somitabun mutant embryos do not respond. Paper-8711339.
In a search for factors differentially expressed in swirl/ bmp2b mutants compared with wild type, we isolated zebrafish Sizzled, a member of the secreted Frizzled-related protein family and putative Wnt inhibitor. Paper-9825687.
Notably, Bozozok appears to function by repressing transcription of target genes such as swr ( bmp2b) gene, and as such is the earliest acting repressor that the nascent dorsal axis is using to antagonize ventral influences. Paper-8773388.
Further observations indicate that the bmp2 gene, in addition to being expressed in the same cells of the basal layer of the epidermis as shh, is also expressed in a subset of the ptc1-expressing cells of the blastema. Paper-1643950.
The boz gene is activated in the organizer in response to beta-catenin signaling, and Boz protein has been demonstrated to contribute to organizer formation by repression of ventralizing genes, including bmp2b, vega1, and vega2. Paper-10190205.
A much stronger dorsalization, similar to that of bmp2b/swirl and bmp7/snailhouse mutants, however, is obtained by inhibiting both maternally and zygotically supplied alk8 gene products with morpholino antisense oligonucleotides. Paper-8711339.
Double mutant analyses and RNA injection experiments show that sbn and bmp2b interact and that sbn acts downstream of Bmp2b signaling to mediate Bmp2b autoregulation during early dorsoventral (D-V) pattern formation. Paper-1882735.
Our results support a model in which specification of anterior neural tissue requires early FGF- mediated repression of BMP transcript levels and later activities of Chordin and mesodermal factors. Paper-11154534.
By analyzing genes whose expression is very sensitive to BMP signaling levels, we found that the absence of Ogon or Chordin antagonism did not increase the BMP activity remaining in swirl/ bmp2b or hypomorphic snailhouse/ bmp7 mutants. Paper-9440522.
Similar to the BMP antagonist chordino, we found that the BMP ligand mutants swirl/ bmp2b and snailhouse/ bmp7 are also epistatic to the putative BMP pathway antagonist, ogon, excluding a class of intracellular antagonists as candidates for ogon. Paper-9440522.
We have studied the role of Bmp signaling in patterning neural tissue through the use of mutants in the zebrafish that disrupt three different components of a Bmp signaling pathway: swirl/ bmp2b, snailhouse/ bmp7 and somitabun/ smad5. Paper-2166859.
Gene co-expression during segmentation (5.5-6.5 mm SL) is similar between tetrapods and zebrafish: bmp2b, bmp4, chordin, and gdf5 in interradial mesenchyme and ZS; bapx1, col2a1, noggin3, and sox9a in chondrocytes. Paper-12588982.
We demonstrate that the snailhouse/ bmp7 null mutant phenotype is identical to the presumptive null mutant phenotype of the strongest dorsalized zebrafish mutant swirl/ bmp2b, revealing equivalent genetic roles for these two Bmp ligands. Paper-2149287.
However, simultaneous knockdown of mini fin and bmp1 results in severe dorsalization resembling the Swirl (swr) and Snailhouse (snh) phenotypes; caused by defects in major zebrafish ventralizing genes bmp2b and bmp7, respectively. Paper-12173049.
Using transgenic lines that ectopically express either noggin3 or bmp2b, we show a requirement for BMP signaling during early segmentation to repress southpaw expression in the right lateral plate mesoderm and regulate both visceral and heart laterality. Paper-13222679.
In the present study, we have used dorsalized swirl ( bmp2b) and ventralized chordino ( chordin) zebrafish mutants to investigate the effects of dorsoventral signalling on endoderm patterning and on the differentiation and positioning of its derivatives. Paper-9628546.
The analysis of Radar overexpression in both swirl/ bmp2b mutants and embryos expressing truncated BMP receptors shows that Radar-induced ventralization is dependent on functional BMP2/4 pathways, and may initially rely on an Alk6-related signaling pathway. Paper-8642066.
We propose that early transcriptional repression of bmp2b by Boz is one of the first steps toward formation of a stable organizer, whereas the later-acting Bmp antagonists (e.g. Chordin, Noggin) modulate Bmp activity in the gastrula to induce patterning along the dorsoventral axis. Paper-9835204.
These results implicate shh and bmp2b signaling in the proliferation and/or differentiation of specialized bone- secreting cells in the blastema and suggest shh expression may be controlled by regulatory feedback mechanisms that define the region of bone secretion in the outgrowing fin. Paper-9165239.
A similar early role for Bmp signaling is suggested in the specification of dorsal neural cell types, since the bmp2b/swirl and bmp7/snailhouse genes are only coexpressed during gastrulation and within the tail bud, and are not found in the dorsal neural tube or overlying epidermal ectoderm. Paper-2166859.
Examination of dorsally and ventrally restricted markers during gastrulation reveals a successive reduction and reciprocal expansion in nonneural and neural ectoderm, respectively, in snailhouse, somitabun, and swirl mutant embryos, with swirl/ bmp2b mutants exhibiting almost no nonneural ectoderm. Paper-1508913.
Based on recent studies with other BMP-dependent promoters (Drosophila vestigial and Xenopus Xvent-2), our studies of the gata2 gene suggest that POU-domain proteins comprise a common component of the BMP signaling pathway, cooperating with Smad proteins and other transcriptional activators. Paper-10772815.
In the expanded ICM, vegf and VEGF receptor 2 ( flk-1) were ectopically co-expressed, suggesting that an autocrine/paracrine regulation of vegf expression may exist and contribute to the BMP-induced hemangiogenic cell proliferation. Paper-10748732.
This study reports expression patterns in the lower jaw dentition of a number of key regulatory genes such as bmp2, bmp4, and sox9 and structural genes such as col1alpha 1 and osteocalcin (= bgp, Bone Gla Protein) by means of in situ hybridization using salmon-specific, digoxygenin-labeled antisense riboprobes. Paper-12959158.
Similar to the amphibian embryo, the key patterning functions of the fish dorsal organizer (i.e., dorsalization of mesoderm, ectoderm, and coordination of gastrulation movements) are performed by secreted molecules that antagonize the ventralizing activity of the swil ( zbmp-2) and zbmp-4 gene products expressed on the ventral side of the embryo. Paper-1651035.
Here we report the cloning and sequencing of the zebrafish vegf promoter which revealed that the promoter contains a number of bone morphogenetic protein (BMP)-activated Smad binding elements (SBE), implicating Smad1 and Smad5 in the regulation of BMP- induced expression of vegf. Paper-10748732.
By analyzing transgenic fish expressing dominant-negative forms of either bone morphogenetic protein (BMP) receptor or fibroblast growth factor (FGF) receptor 1, we demonstrate that the BMP and FGF signaling pathways are crucial regulators of the early events during liver regeneration after PH. Paper-14024689.
These synonyms are used for gene bmp2b (bone morphogenetic protein 2b): zbmp-2, zbmp2, MGC92556, MGC136722, cb670, bmp2-4, bmp-2, bmp2.
These accession numbers are used for gene bmp2b: O57573 (UNIPROT__AC), O13108 (UNIPROT__AC), BC114256 (NCBI_GENBANK__AC), AF072456 (NCBI_GENBANK__AC).
bmp2b is a homologue of dpp (decapentaplegic) from Drosophila melanogaster.
bmp2b is a homologue of BMP2 (bone morphogenetic protein 2) from Homo sapiens.
bmp2b is a homologue of BMP2 (bone morphogenetic protein 2) from Bos taurus.
bmp2b is a homologue of BMP2 (bone morphogenetic protein 2) from Pan troglodytes.
bmp2b is a homologue of BMP2 (bone morphogenetic protein 2) from Gallus gallus.
bmp2b is a homologue of BMP2 (bone morphogenetic protein 2) from Canis lupus familiaris.
bmp2b is a homologue of Bmp2 (bone morphogenetic protein 2) from Mus musculus.
bmp2b is a homologue of Bmp2 (bone morphogenetic protein 2) from Rattus norvegicus.
bmp2b is a homologue of AgaP_AGAP007987 (AGAP007987-PA) from Anopheles gambiae str. PEST.
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