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One of the functions regulated by HSCARG may be argininosuccinate synthetase that is involved in NO synthesis. Paper-13253350.
Renal argininosuccinate synthetase: purification, immunohistochemical localization, and elastin-binding property. Paper-7503089.
Adult-onset type II citrullinemia ( CTLN2) is characterized by a liver-specific deficiency of argininosuccinate synthetase (ASS) protein. Paper-8649469.
Argininosuccinate synthetase and argininosuccinate lyase: two ornithine cycle enzymes from Agaricus bisporus. Paper-13272645.
Activated microglia cells express argininosuccinate synthetase and argininosuccinate lyase in the rat brain after transient ischemia. Paper-12585181.
This requires the sequential action of two enzymes, argininosuccinate synthetase (AS) and argininosuccinate lyase ( AL). Paper-10524364.
Argininosuccinate-synthetase (ASS), argininosuccinate-lyase ( ASL) and nitric oxide synthase (NOS) act in the l-arginine-NO-l-citrulline cycle. Paper-12585181.
Nitric oxide synthase (NOS), argininosuccinate synthetase (ASS), and argininosuccinate lyase ( ASL) compose a cyclic pathway to form nitric oxide (NO). Paper-1377693.
Transient ischemia increases neuronal nitric oxide synthase, argininosuccinate synthetase and argininosuccinate lyase co-expression in rat striatal neurons. Paper-13140855.
Quantitative PCR was utilized to determine liver GS, CPS, OCT, ARG, argininosuccinate synthetase (ASS) and argininosuccinate lyase ( ASL) mRNA expression. Paper-13781195.
Hepatocellular carcinoma ( HCC) is believed to be auxotrophic for arginine through the lack of expression of argininosuccinate synthetase (ASS). Paper-12396771.
Argininosuccinate synthetase (ASS), argininosuccinate lyase ( ASL) and nNOS act in the L-arginine-NO-L-citrulline cycle permitting a correct NO production. Paper-13140855.
An NADPH sensor protein ( HSCARG) down-regulates nitric oxide synthesis by association with argininosuccinate synthetase and is essential for epithelial cell viability. Paper-12758449.
In this work the nucleotide sequences of the genes and corresponding cDNAs encoding argininosuccinate synthetase (ass) and argininosuccinate lyase ( asl) from Agaricus bisporus were determined. Paper-13272645.
The enzymes involved in citrulline-arginine metabolism, argininosuccinate synthetase (ASS), argininosuccinate lyase ( ASL), and NOS were expressed in rat islets and insulinoma HIT T15 cells. Paper-1073947.
These effects were mimicked by 10(-4) M Bt2cAMP, but the activities of ornithine transcarbamylase ( OTC) and argininosuccinate synthetase (ASS) were never changed by the addition of these compounds. Paper-5531633.
The activities of the arginine recycling enzymes, argininosuccinate synthetase (ASS) and argininosuccinate lyase ( ASL) were both decreased in lung tissues of Shunt lambs while arginase activity was increased. Paper-14572745.
Argininosuccinate synthetase (ASS) and argininosuccinate lyase ( ASL) are two ornithine cycle enzymes catalysing the last two steps in the arginine biosynthetic pathway. Paper-13272645.
CTLN2 differs from classical citrullinaemia ( CTLN1, OMIM 215700) in that CTLN1 is neonatal or infantile in onset, with ASS enzyme defects (in all tissues) arising due to mutations in ASS on chromosome 9q34 (refs 18-21). Paper-1881897.
We found increased mRNA levels of inducible nitric oxide synthase ( iNOS) and the arginine regenerating enzyme argininosuccinate synthetase (ASS) within cortices of AD patients suggesting high output NO production. Paper-9436348.
Argininosuccinate synthetase (ASS) is a ATP-dependent and rate-limiting enzyme of the urea cycle which catalyzes L-citrulline to L-arginine in combination with argininosuccinate lyase ( ASL). Paper-6803373.
The expression of two genes, coding for argininosuccinate synthetase (ASS) and argininosuccinate lyase ( ASL), enzymes which synthesize arginine, was studied by Northern analysis in various tissues of fetal rats. Paper-8277507.
Citrulline, which is formed as a by-product of the NOS reaction, can be recycled to arginine by the 2 enzymes acting in the urea cycle: argininosuccinate synthetase (ASS) and argininosuccinate lyase ( ASL). Paper-13617694.
There are five key enzymes in the urea cycle: carbamoyl-phosphate synthetase 1 ( CPS1), ornithine transcarbamylase ( OTC), argininosuccinate synthetase ( ASS1), argininosuccinate lyase ( ASL), and arginase 1 ( ARG1). Paper-13529627.
Cerebral creatine and guanidinoacetate and blood and urine metabolites were studied in four patients with argininosuccinate synthetase (ASS) or argininosuccinate lyase (ASL) deficiency receiving large doses of arginine. Paper-14710224.
Citrulline formed as a by-product of the NOS reaction, can be recycled to arginine by successive actions of argininosuccinate synthetase (ASS) and argininosuccinate lyase ( ASL) via the citrulline-NO cycle. Paper-10753757.
Free citrulline metabolism involves three key enzymes: NO synthase (NOS) and ornithine carbamoyltransferase ( OCT) which produce citrulline, and argininosuccinate synthetase (ASS) that converts it into argininosuccinate. Paper-11486658.
Carbamoylphosphate synthetase (CPS), ornithine aminotransferase (OAT), argininosuccinate synthetase (ASS), arginase-1 ( ARG1), arginase-2 (ARG2), and nitric-oxide synthase (NOS) were visualized by semiquantitative immunohistochemistry in 89 small-intestinal specimens. Paper-13547967.
We previously reported that argininosuccinate synthetase (ASS) and argininosuccinate lyase ( ASL), together with NOS, constitute the citrulline-argininosuccinate-arginine (Cit-AS-Arg) cycle in beta-cells and that this cycle metabolizes citrulline to produce NO and increase cytosolic Ca2+ concentration ([Ca2+]i) in islet beta-cells. Paper-9999188.
Expression profiling of argininosuccinate synthetase (ASS), argininosuccinate lyase ( ASL) and OTC in 40 HCC tumor biopsy specimens predicted that 16 of the patients would be rhArg-sensitive, compared with 5 who would be sensitive to arginine deiminase (ADI), another arginine-depleting enzyme with anti-tumor activity. Paper-13669941.
These synonyms are used for gene ASS1 (argininosuccinate synthase 1): CTLN1, Citrulline--aspartate ligase, ASS, Argininosuccinate synthase.
These accession numbers are used for gene ASS1: Q96GT4 (UNIPROT__AC), Q6LDL2 (UNIPROT__AC), AAH21676 (NCBI_GENBANK__AC), AAA51782 (NCBI_GENBANK__AC).
ASS1 is a homologue of NCU02639 (argininosuccinate synthase) from Neurospora crassa OR74A.
ASS1 is a homologue of MGG_12360 (hypothetical protein) from Magnaporthe oryzae 70-15.
ASS1 is a homologue of MGG_07169 (hypothetical protein) from Magnaporthe oryzae 70-15.
ASS1 is a homologue of KLLA0C04037g (hypothetical protein) from Kluyveromyces lactis NRRL Y-1140.
ASS1 is a homologue of CG1315 (CG1315 gene product from transcript CG1315-RA) from Drosophila melanogaster.
ASS1 is a homologue of ASS1 (argininosuccinate synthase 1) from Bos taurus.
ASS1 is a homologue of ASS1 (argininosuccinate synthase 1) from Pan troglodytes.
ASS1 is a homologue of ASS1 (argininosuccinate synthase 1) from Gallus gallus.
ASS1 is a homologue of ASS1 (argininosuccinate synthase 1) from Canis lupus familiaris.
ASS1 is a homologue of Ass1 (argininosuccinate synthetase 1) from Mus musculus.
ASS1 is a homologue of Ass1 (argininosuccinate synthetase 1) from Rattus norvegicus.
ASS1 is a homologue of ass1 (argininosuccinate synthetase 1) from Danio rerio.
ASS1 is a homologue of arg12 (argininosuccinate synthase (predicted)) from Schizosaccharomyces pombe.
ASS1 is a homologue of ARG1 (Arg1p) from Saccharomyces cerevisiae S288c.
ASS1 is a homologue of AGOS_AER230C (AER230Cp) from Ashbya gossypii ATCC 10895.
ASS1 is a homologue of AgaP_AGAP003015 (AGAP003015-PA) from Anopheles gambiae str. PEST.
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