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This hypothesis was pursued in the present study by modulating NOS3 and ASS1 levels in cultured endothelial cells. Paper-15637031.
SiRNAs of NOS3 and ASS1 attenuated the increase of NO production in human aortic endothelial cells stimulated by LSS (12 dynes·cm(-2)) for 24 h. Paper-15637031.
Recent studies demonstrated that LSS also increases the expression of argininosuccinate synthetase 1 ( ASS1) that regulates the provision of L-arginine, the substrate of NOS3. Paper-15637031.
The latter effect of overexpressed ASS1 was reduced when human umbilical vein endothelial cells were co-treated with small interfering RNAs (siRNAs) for ASS1 or NOS3. Paper-15637031.
Exogenous expression of either NOS3 or ASS1 in human umbilical vein endothelial cells increased NO production and decreased monocyte adhesion stimulated by tumor necrosis factor-α (TNF-α). Paper-15637031.
However, gene-by-gene interaction analysis conducted using the MDR approach revealed a significant interactive genetic effect of ASS1 (rs666174) and SLC25A13 (rs10252573) on the occurrence of clefting (p=0.002). Paper-15428105.
The current study suggests that the expression of ASS1 harmonized with that of NOS3 may be important for the optimized endothelial NO production and the prevention of the inflammatory monocyte adhesion to endothelial cells. Paper-15637031.
LSS inhibited monocyte adhesion to human aortic endothelial cells stimulated by TNF-α, but this effect of LSS was abrogated by siRNAs of NOS3 and ASS1 that recovered the expression of vascular cell adhesion molecule-1. Paper-15637031.
Microarray analysis identified upregulation of asparagine synthetase (ASNS) and argininosuccinate synthase 1 ( ASS1) to cell lines with acquired resistance to L-asp, and in the case of DNR, upregulation of ATP-binding cassette B1 (ABCB1). Paper-12483622.
DESIGN: PCR-RFLP and HRM analyses were used to analyze single nucleotide polymorphisms ( SNPs) of ASS1, ASL, and SLC25A13 in 172 children with non-syndromic cleft lip with or without cleft palate (CL/ P) and 188 controls without congenital anomalies. Paper-15428105.
These synonyms are used for gene ASS1 (argininosuccinate synthase 1): CTLN1, Citrulline--aspartate ligase, ASS, Argininosuccinate synthase.
These accession numbers are used for gene ASS1: Q86UZ0 (UNIPROT__AC), Q6LDL2 (UNIPROT__AC), CR598119 (NCBI_GENBANK__AC), AK027126 (NCBI_GENBANK__AC).
ASS1 is a homologue of Os12g0235800 (Os12g0235800) from Oryza sativa Japonica Group.
ASS1 is a homologue of NCU02639 (argininosuccinate synthase) from Neurospora crassa OR74A.
ASS1 is a homologue of MGG_12360 (hypothetical protein) from Magnaporthe oryzae 70-15.
ASS1 is a homologue of MGG_07169 (hypothetical protein) from Magnaporthe oryzae 70-15.
ASS1 is a homologue of KLLA0C04037g (hypothetical protein) from Kluyveromyces lactis NRRL Y-1140.
ASS1 is a homologue of CG1315 (CG1315 gene product from transcript CG1315-RA) from Drosophila melanogaster.
ASS1 is a homologue of AT4G24830 (arginosuccinate synthase family) from Arabidopsis thaliana.
ASS1 is a homologue of ASS1 (argininosuccinate synthase 1) from Pan troglodytes.
ASS1 is a homologue of ASS1 (argininosuccinate synthase 1) from Canis lupus familiaris.
ASS1 is a homologue of ASS1 (argininosuccinate synthase 1) from Bos taurus.
ASS1 is a homologue of ASS1 (argininosuccinate synthase 1) from Gallus gallus.
ASS1 is a homologue of Ass1 (argininosuccinate synthetase 1) from Mus musculus.
ASS1 is a homologue of Ass1 (argininosuccinate synthetase 1) from Rattus norvegicus.
ASS1 is a homologue of ass1 (argininosuccinate synthetase 1) from Danio rerio.
ASS1 is a homologue of arg12 (argininosuccinate synthase (predicted)) from Schizosaccharomyces pombe 972h-.
ASS1 is a homologue of ARG1 (Arg1p) from Saccharomyces cerevisiae S288c.
ASS1 is a homologue of AGOS_AER230C (AER230Cp) from Ashbya gossypii ATCC 10895.
ASS1 is a homologue of AgaP_AGAP003015 (AGAP003015-PA) from Anopheles gambiae str. PEST.
Important links !
iHOP - Information Hyperlinked over Proteins .
Concept & Implementation by Robert Hoffmann.