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In addition, CIS was activated by Epo but not SCF. Paper-8406308.
EPO also slightly enhanced expression of GPIIb/IIIa. Paper-6226898.
Human hematopoietic progenitors express erythropoietin. Paper-1439719.
EPO treatment was without influence on AVP plasma levels. Paper-8488.
This therapy may also enhance the hematopoietic effects of EPO. Paper-9311970.
There was no competition between TPO and EPO for binding to EPO receptor. Paper-1546278.
EPO also enhanced the CA1 level of brain-derived neurotrophic factor. Paper-11821239.
On the other hand, Epo had no effect on number and affinity of GM-CSF receptors. Paper-7388892.
Overexpression of CYP2C8 in Hep3B induced EPO and VEGF under hypoxia. Paper-13012255.
Does parathyroid hormone affect erythropoietin therapy in dialysis patients? Paper-12375440.
The improvement in EPO responsiveness may be caused by the effect of statins on CRP. Paper-9940047.
Epo binding induces the stimulation of Jak2 tyrosine kinase. Paper-1646591.
Epo binding induces stimulation of the Jak2 tyrosine kinase. Paper-1883153.
Thus, erythroid development of M-TAT cells is promoted by EPO and suppressed by GM-CSF. Paper-137135.
IFN-gamma produced significant increases in medium levels of Epo and nitrite. Paper-988470.
Erythrocytosis caused by an erythropoietin- producing hepatocellular carcinoma. Paper-8608254.
CONCLUSIONS: Urine characteristics clearly affect the detectability of an EPO profile. Paper-12495111.
IL-6 dependent pathways could be involved in mediating elevated EPO levels in CLD patients. Paper-10354359.
These studies suggest that SHP-1 and Jak2 are constitutively associated in UT-7/ EPO cells. Paper-8459741.
Finally, Epo- induced signal transduction was also inhibited in cells lacking Btk. Paper-10428208.
The cytokines IL-1 beta and TNF prevented this hypoxia- induced increase in Epo mRNA levels. Paper-145384.
Both the production and the action of EPO may fall under the control of IL-1 and IFN-gamma. Paper-1141470.
TGF-beta also inhibited hypoxia- induced Epo production, but only by as much as 56%. Paper-7211427.
Interleukin 2 and erythropoietin activate STAT5/ MGF via distinct pathways. Paper-259794.
IL-4 alone neither supports nor suppresses the erythropoietin (Epo)-dependent colony formation. Paper-6667046.
Indeed, Epo induced the transient tyrosine phosphorylation of GAB1 in UT-7 cells. Paper-1812483.
However, BFU-E responses to SCF and erythropoietin were suppressed in STAT(-/-) mice. Paper-8388675.
(c) SPTB remains unmethylated in human DNA from UT-7/ EPO cells and from cultured erythroblasts. Paper-11494708.
However, the postnatal EPO treatment did not prevent LPS- stimulated loss of MBP-positive staining. Paper-12543806.
When IL-3 was connected to Epo by a short linker, the binding affinity of the IL-3 moiety was lower. Paper-7701549.
Expression of HIF-1alpha and its target genes EPO, VEGF and p21 was also upregulated. Paper-12128895.
Neural progenitor cells treated with EPO induce angiogenesis through the production of VEGF. Paper-12849074.
Our results suggest that PI3K/Akt and GSK-3beta pathway are involved in the neuroprotective effect of EPO. Paper-12597777.
While the postnatal EPO treatment prevented LPS- induced brain injury this effect was partial. Paper-12543806.
The PKC inhibitors staurosporine and calphostin C prevented EPO- induced erythroid differentiation. Paper-2079999.
EPA potentiated the effect of Epo on this progenitor only in experiments performed at unicellular level. Paper-6264065.
In UT-7 cells, both GM-CSF and EPO induced the activation of Stat1 alpha, Stat3 and Stat5. Paper-1424448.
A protective effect of erythropoietin against Fas- induced BAP31 cleavage and apoptosis was observed. Paper-13034992.
Stem cell factor ( SCF) stimulates proliferation of UT-7/ Epo only transiently, for three to five days. Paper-8406308.
In this study, we examined the roles of Stat1alpha and Stat3 in EPO- induced erythroid differentiation. Paper-1501349.
Furthermore, perfusion with EPO resulted in a 50% increase in the phosphorylated MAP kinases p42/ p44. Paper-11431267.
In contrast, erythropoietin starvation induces the nuclear export of Hsp70 and the cleavage of GATA-1. Paper-12393190.
Recombinant murine interleukin 9 enhances the erythropoietin-dependent colony formation of human BFU-E. Paper-7391985.
Neurogenin 1 mediates erythropoietin enhanced differentiation of adult neural progenitor cells. Paper-11399930.
Thus, EPO presents as an interesting candidate to enhance and modulate the regenerative effect of BDNF on SGN. Paper-12976269.
The role of interleukin 1, erythropoietin and red cell bound immunoglobulins in the anaemia of rheumatoid arthritis. Paper-7072458.
Increased levels of C-reactive protein ( CRP) have been associated with relative EPO resistance in dialysis patients. Paper-9940047.
Furthermore, IL-1 beta (10 U/ml) proved to block Epo formation in isolated serum-free perfused rat kidneys. Paper-7518582.
Incubation with EPO (10(-13)-10(-10) M) stimulated mitogen-activated protein kinase activity in PC12 cells. Paper-1861280.
Protective effect of erythropoietin on beta-amyloid- induced PC12 cell death through antioxidant mechanisms. Paper-12961766.
Taken together, these results show that PtdIns 3-kinase controls Epo- induced GPI hydrolysis through PLC-gamma2. Paper-9315543.
UT-7/ EPO cells expressing c-Mpl changed their morphology and the other characteristics similar to the UT-7/ TPO cells. Paper-1926699.
Conversely, IL-6- induced enhancement was blocked by the anti- IL-6 antibody but not by the anti- Epo antibody. Paper-7104146.
Erythropoietin attenuates lipopolysaccharide- induced white matter injury in the neonatal rat brain. Paper-12543806.
Hypoxia-inducible factor-1 ( HIF-1) regulates the expression of neuroprotective genes such as erythropoietin ( EPO). Paper-12854007.
It was concluded that erythropoietin- induced protection from apoptosis involved JAK2, but not MAP kinases or c-jun. Paper-11783989.
Incubation with thapsigargin resulted in decreased EPO synthesis (P < 0.05) but stimulated VEGF secretion (P < 0.05). Paper-1920627.
CONCLUSIONS: We show that upon extended exposure, EPO induces NOS activity but does not affect ET-1 release. Paper-8493313.
Erythropoietin ( EPO) induces endothelin expression in endothelial cells (EC) and has angiogenic effects. Paper-779582.
Concomitant measurements of the production of alpha-fetoprotein indicated that the observed effects were specific for Epo. Paper-6955028.
Zinc inhibited hypoxia-induced increases in HIF-1 DNA- binding activity and the HIF-1-dependent mRNA expression of EPO. Paper-12854007.
Excessive level of parathyroid hormone may induce the reduction of recombinant human erythropoietin effect on renal anemia. Paper-376547.
This preliminary study shows that EPO may inhibit GH secretion from the pituitary gland and IGF-1 production. Paper-11619869.
Hepatic release of erythropoietin induced by transarterial chemoembolization in patients with hepatocellular carcinoma. Paper-280555.
Juvenile hemochromatosis associated with B-thalassemia treated by phlebotomy and recombinant human erythropoietin. Paper-8591328.
Neuroprotective effect of erythropoietin after experimental cold injury- induced vasogenic brain edema in rats. Paper-12769177.
In contrast, an inhibitor of the ERK/MAP kinase pathway (PD98059) had no effect on Epo-independent terminal differentiation. Paper-10404918.
Erythropoietin protects CA1 neurons against global cerebral ischemia in rat: Potential signaling mechanisms. Paper-11821239.
Human telomerase is regulated by erythropoietin and transforming growth factor-beta in human erythroid progenitor cells. Paper-12531062.
Following binding to the 3' hypoxia-response element (HRE) of the Epo gene, HIF-1 markedly enhances Epo transcription. Paper-8378248.
Amniotic fluid erythropoietin showed an independent effect on cord serum CRP in multiple regression analysis. Paper-10441256.
Higher susceptibility of erythropoietin- producing renal cell carcinomas to lysis by lymphokine-activated killer cells. Paper-998842.
These motifs are also found on cytokine, erythropoietin and growth hormone receptors and provide docking sites for JAK kinases. Paper-1937152.
In contrast, GM-CSF and IL-3 both induced GM colonies and sustained the formation of erythroid bursts in the presence of Ep. Paper-5799792.
In this study, we propose a new approach for blocking EP- mediated cell signaling using a soluble chimeric EP2 fragment. Paper-12947145.
While HIF-1 and HIF-2 activate the EPO gene, HIF-3, GATA-2 and NFkappaB are likely inhibitors of EPO gene transcription. Paper-10561481.
Treatment of the cells with antisense-vav and -p85 abrogated Epo- induced cell proliferation and PI3-kinase activity. Paper-1038443.
Interleukin-10 inhibits erythropoietin-independent growth of erythroid bursts in patients with polycythemia vera. Paper-1567810.
The levels of carbonic anhydrase I in K562 cells induced by erythropoietin and in other blood cells were determined. Paper-6545898.
Taken together, these results suggest that Epo enhances plasma cell responses by a different mechanism than does IL-6. Paper-7104146.
Recombinant human erythropoietin induces a delayed increase in reticulocytosis and in soluble transferrin receptor levels. Paper-9891725.
Northern blot analysis of CA-I mRNA using a cloned genomic DNA as a probe showed that mRNA of CA-I was induced by EP. Paper-7135716.
In addition, we have shown that EPO stimulates the formation of a ternary complex consisting of Ship1, Shc, and Grb2. Paper-2129008.
Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelial cells. Paper-10559611.
Recombinant human erythropoietin stimulates vascular endothelial growth factor release by glomerular endothelial cells. Paper-1941060.
Our results demonstrate that PKB/Akt is activated by Epo and SCF, but not by IGF-1 in human primary erythroid progenitors. Paper-8430288.
The gp130 receptor-ligand complexes are contrasted with the complex formed by erythropoietin ( Epo) and its receptor, EpoR. Paper-9996440.
Stimulation of GATA-2 as a mechanism of hydrogen peroxide suppression in hypoxia- induced erythropoietin gene expression. Paper-8674799.
Wortmannin, another PtdIns 3-kinase inhibitor, also suppressed Epo- induced PLC-gamma2 tyrosine phosphorylation. Paper-9315543.
Activation of the Akt/ FKHRL1 pathway mediates the antiapoptotic effects of erythropoietin in primary human erythroid progenitors. Paper-8430288.
Furthermore, the inhibition of JNK using small interference RNA (siRNA) suppressed EPO-enhanced proliferation of AR42J cells. Paper-12963825.
EPO treatment of MoDCs was also associated with an increase in surface expression of CD80 and CD86 as well as that of HLA-DR. Paper-13093623.
RESULTS: EPO induced a 5.0-fold+/-0.4-fold increase in STAT5 transactivation, which could be further enhanced by SCF. Paper-9766422.
CONCLUSION: Treatment with EPO significantly inhibits the LPS- induced secretion of midkine and TNF-alpha regardless of the dosage. Paper-12866425.
On the contrary, EPO activates neither JAK2 nor STAT5 in other cell lines that failed to respond to EPO ( ERT cells). Paper-259794.
A case of erythrocytosis caused by a hepatocellular carcinoma ( HCC) that produced erythropoietin ( Epo) is described. Paper-8608254.
Furthermore, forced expression of hypoxia-inducible factor-1alpha ( HIF-1alpha) enhanced Epo production in all oxygen concentrations. Paper-2094527.
Taken together, our data suggest that Stat1alpha and Stat3 act as negative regulators in EPO- induced erythroid differentiation. Paper-1501349.
Prostaglandin-E2 enhances EPO- mediated STAT5 transcriptional activity by serine phosphorylation of CREB. Paper-9498698.
Finally, expression of endogenous TEL proteins in UT-7/GM cells was down-regulated following erythropoietin and thrombopoietin exposure. Paper-10780244.
Thus, activation of AT1 with angiotensin II enhances erythropoietin-stimulated erythroid proliferation in vitro. Paper-1248131.
High blood soluble receptor p80 for tumour necrosis factor-alpha is associated with erythropoietin resistance in haemodialysis patients. Paper-8938030.
Immunoreactive serum erythropoietin concentrations were measured in 35 patients with anaemia associated with active rheumatoid arthritis. Paper-6710643.
Erythropoietin promotes endothelial progenitor cell proliferative and adhesive properties in a PI 3-kinase-dependent manner. Paper-11007465.
A role for heme oxygenase-1 in the antioxidant and antiapoptotic effects of erythropoietin: the start of a good news/bad news story? Paper-12042807.
Among these growth factors, erythropoietin ( EPO) and granulocyte colony- stimulating growth factor ( G-CSF) are the most prominent. Paper-12820602.
These findings suggest a suppressed serum EPO response ot anemia and the effectiveness of r- EPO in treating anemia associated with RA. Paper-6729630.
Recombinant human erythropoietin inhibits iNOS activity and reverts vascular dysfunction in splanchnic artery occlusion shock. Paper-2010345.
Erythropoietin reduces lipopolysaccharide- induced cell Damage and midkine secretion in U937 human histiocytic lymphoma cells. Paper-12866425.
Interestingly, not only was this increase not seen with IL-3, but IL-3 prevented the Ep- induced appearance of beta-globin message. Paper-147270.
Recombinant human erythropoietin stimulates production of interleukin 2 by whole blood cell cultures of hemodialysis patients. Paper-10568163.
Recombinant human erythropoietin stimulates production of interleukin 2 by whole blood cell cultures of hemodialysis patients. Paper-2054580.
Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha. Paper-12826285.
RESULTS: EPO treatment decreased hypoxia- induced HIF-1alpha protein levels and VEGF transcription, with no effect on cell growth. Paper-10822271.
Lack of influence of recombinant human erythropoietin on parathyroid function in hemodialysis patients with secondary hyperparathyroidism. Paper-360348.
Erythropoietin protects primary hippocampal neurons increasing the expression of brain-derived neurotrophic factor. Paper-11141786.
Furthermore, our data show that Gab1 is the primary IRS-related protein activated by erythropoietin in primary erythroid progenitor cells. Paper-1990473.
CONCLUSION: SCF enhances the EPO- mediated STAT5 transactivation by triggering a PKA/ CREB-dependent pathway. Paper-9766422.
By using nonadherent mononuclear cells from peripheral blood, Epo-dependent colony formation was enhanced by IL-3 and GM-CSF in PV patients. Paper-6232808.
Epo gene expression has been previously shown to be down-regulated through a GATA binding site at its promoter region. Paper-8674799.
Human recombinant erythropoietin (rHuEPO) was produced from Chinese hamster ovary (CHO) cells transfected with the human EPO gene. Paper-12004696.
To our knowledge, this is the first study that demonstrates a protective effect of EPO on LPS- induced WM injury in the developing brain. Paper-12543806.
We suggest that MAPK activation reflects a physiologically relevant effect of Epo on VSMCs that may be correlated to cell proliferation. Paper-8845753.
The restoring effect of EPO in the RAW264.7 cells was associated with the increased of c-Fos and c-Jun expression as well as AP-1 activation. Paper-11389386.
Using this cell line, we examined the effect of a truncated human EPO receptor ( EPOR-T) on EPO- induced erythroid differentiation. Paper-1749577.
Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, inhibits erythropoietin- induced erythroid differentiation of K562 cells. Paper-534255.
However, markers of an underlying inflammatory state and of secondary hyperparathyroidism were associated with decreased response to erythropoietin. Paper-8674874.
Our results suggest that the Src kinase Lyn is involved in PLC-gamma 2 phosphorylation and PI 3-kinase activation induced by Epo. Paper-9684969.
In vitro kinase assay using histone H2B and glucose synthase kinase as substrates demonstrated that Akt was actually activated by EPO. Paper-8364491.
These results suggest that EPOR-T is a negative regulator of EPO- induced anti-apoptosis and EPO- induced erythroid differentiation. Paper-1749577.
These findings suggest that pp60c-src plays crucial roles in the proliferation and EPO- induced erythroid differentiation of K562 cells. Paper-8223764.
We recently found that erythropoietin produced by erythroid progenitors stimulates erythropoiesis via gp130 and c-kit signals. Paper-8540730.
Epo was also able to activate p21ras as measured by exchange of guanosine diphosphate for guanosine triphosphate. Paper-63263.
Our results strongly support a role for the common beta chain CD131 in the protective effect of EPO derivatives on motoneuron degeneration. Paper-12305474.
The differential stimulation of neovascularization by EPO was associated with increased EPO-receptor and VEGF expression in ischemic hearts only. Paper-13084446.
Hypoxia-induced transcription from the Epo promoter was specifically enhanced by ectopic p300 and inhibited by E1A binding to p300/ CBP. Paper-781896.
Moreover, it was found that EPO- induced downregulation of EPOR mRNA level was preceded by a transient downregulation of GATA-1 mRNA. Paper-905785.
Erythropoietin stimulates growth and STAT5 phosphorylation in human prostate epithelial and prostate cancer cells. Paper-10842001.
Recombinant human erythropoietin enhances superoxide production by FMLP-stimulated polymorphonuclear leukocytes in hemodialysis patients. Paper-1221482.
In contrast, Epo induced a marked erythroid differentiation with an increase of glycophorin A expression, accompanied by a few hemoglobinized cells. Paper-7388892.
In addition, Epo uniquely induced phosphorylation of a 72-kDa substrate while IL-3 uniquely induced phosphorylation of a 140-kDa substrate. Paper-7168368.
These results support a role for the specific erythropoietin- induced Janus kinase 2/ STAT signal transduction pathway in PDT resistance. Paper-12917926.
This study examined whether EPO can protect against neuronal death in the CA1 region of the rat hippocampus following global cerebral ischemia. Paper-11821239.
Epo- induced tyrosine phosphorylation of GAB1 was also observed in normal human erythroid progenitors isolated from cord blood. Paper-1812483.
The vascular protective effect of Epo against cerebral vasospasm induced by SAH may be mediated in part by phosphorylation of Akt/ eNOS. Paper-11027246.
CONCLUSIONS: The EPO- induced STAT3 serine 727 phosphorylation is mediated by a pathway involving MEK, ERK, and MSK1. Paper-9660261.
Erythropoietin receptor mutations associated with familial erythrocytosis cause hypersensitivity to erythropoietin in the heterozygous state. Paper-2024259.
The loss of VHL function may result in the accumulation of HIF-1alpha and overproduction of HIF-1 downstream target genes including Epo. Paper-9661944.
The PI3-kinase/ AKT signaling pathway is identified as a mediator of Epo- induced phosphorylation of GATA-1. Paper-10815635.
In contrast, R103A homodimer induces proliferation and transduces signal at concentrations similar to that of wild-type Epo monomer and homodimer. Paper-1425057.
The effect of erythropoietin, with or without transferrin-iron is blocked by pre-incubation of the erythropoietin with rabbit anti erythropoietin serum. Paper-3789706.
It was previously shown that HNF-4 functions as a tissue-specific and hypoxia- activated transcription factor for the erythropoietin ( Epo) gene. Paper-9597035.
Differentiating CD34(+) cells that are stimulated with recombinant human EPO in serum-free liquid cultures express both EPO and EPO receptor ( EPOR). Paper-1439719.
The addition of IL-1 alpha, IL-1 beta, or TNF-alpha resulted in a dose-dependent inhibition of hypoxia- induced Epo production by as much as 89%. Paper-7211427.
Administration of recombinant human erythropoietin to these mice failed to reverse the suppressed erythropoiesis in mice bearing TNF producing tumors. Paper-6170898.
In conclusion, erythropoietin may attenuate high glucose- induced endothelial cell apoptosis via PI-3 kinase pathway. Paper-10740186.
EPO binds to an erythroid progenitor cell surface receptor that includes a p66 chain, and, when activated, the p66 protein becomes dimerized. Paper-9776170.
Male gender, diabetes as cause of ESRD, older age, higher transferrin saturation and higher albumin concentrations were associated with lower Epo/Hb index. Paper-9719204.
Protein kinase C-alpha isoform is involved in erythropoietin- induced erythroid differentiation of CD34(+) progenitor cells from human bone marrow. Paper-2079999.
Stimulation with either TPO or EPO induced rapid increases in adhesion of M07ER cells to fibronectin without apparent change of expression of integrins. Paper-1290176.
This unliganded EPOR dimer is formed from self-association of the same key binding site residues that interact with EPO-mimetic peptide and EPO ligands. Paper-1745948.
We show that VHL disease- associated renal clear cell carcinomas (RCC) consistently coexpress erythropoietin ( Epo) and Epo receptor (EpoR). Paper-10772509.
We describe here that EPO activates hTERT gene transcription in in vitro-expanded primary erythroid precursors as well as in UT7 erythroleukemia cells. Paper-12531062.
Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin- induced cell proliferation and Stat5 activation. Paper-439006.
Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/ AKT signaling pathway. Paper-10815635.
It is concluded that cobalt stimulates a signal cascade with cytochrome b as receptor and H2O2 as second messenger for regulating erythropoietin production. Paper-126312.
In summary, these studies demonstrate that PGE2 enhancement of EPO- induced STAT5 transactivation is mediated by the cAMP/PKA/ CREB pathway. Paper-9498698.
Interleukin-1 ( IL-1) and tumor necrosis factor-alpha ( TNF-alpha) have been reported to inhibit the synthesis of erythropoietin ( EPO) in vitro. Paper-1181075.
In this report, we demonstrate that insulin receptor substrate-2 ( IRS-2) is phosphorylated on tyrosine following treatment of UT-7 cells with erythropoietin. Paper-1206734.
Flow cytometric analysis showed that incubation of K562 cells with EP as well as hemin induced CA-I at the 3rd h, while alpha-globin was detected at the 8th h. Paper-7135716.
We used alanine substitution of EBP residues that contact EMP1 in the crystal structure to investigate the function of these residues in both EMP1 and EPO binding. Paper-1866584.
Epo production was inhibited by MS from patients compared to controls both before and after stimulation with LPS (P < 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS) Paper-7927997.
Antisense src RNA expression in K562 cells inhibited the erythropoietin- induced activatio