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Glomerular deposition of Hageman factor in IgA nephropathy. Paper-4597051.
At the same time, the domain error of conventional LMP2 is removed in LMP2- F12. Paper-13610787.
Inhibition of the activation of Hageman factor (factor XII) by beta 2-glycoprotein I. Paper-5898686.
Mechanisms for Hageman factor activation and role of HMW kininogen as a coagulation cofactor. Paper-3929184.
Normal platelet adhesiveness and aggregation in congenital PTA or Hageman factor deficiency. Paper-3679691.
Questions have been raised about the role of HMWK in the activation of Hageman factor by surfaces. Paper-4487869.
A local explicitly correlated LMP2- F12 method is described that can be applied to large molecules. Paper-13610787.
The defect in each assay was reconstituted by afactor separable from Hageman factor or Fletcher factor. Paper-2376384.
Enzymatic properties of human Hageman factor fragment with plasma prekallikrein and synthetic substrates. Paper-3659386.
Activation of human factor XI ( plasma thromboplastin antecedent) by factor XIIa (activated Hageman factor). Paper-2787250.
Interaction between factor XII ( Hageman factor), high molecular weight kininogen and prekallikrein. Paper-2625805.
Rapid triplex asymmetric real-time PCR hybridization probe assay for the joint genotyping of F2, F5 and F12. Paper-14546684.
Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time. Paper-15232576.
All these sera recognized a 185-kD band that co-migrated with the polypeptide labeled by MoAb F12 on immunoblots. Paper-7664549.
Mechanisms for the involvement of high molecular weight kininogen in surface-dependent reactions of Hageman factor. Paper-2627086.
The inhibition of activated factor XII ( Hageman factor) by antithrombin III: the effect of other plasma proteinase inhibitors. Paper-2882372.
Moreover, rapid proteolytic inactivation of Factor XII ( Hageman factor) by MMP-12, MMP-13, and MMP-14 was noted. Paper-8654649.
In contrast, once Hageman factor was activated by kaolin, its clot-promoting properties were not inhibited by beta 2-glycoprotein I. Paper-5898686.
Guinea pig macroalbumin. A major inhibitor of activated Hageman factor in plasma with an alpha 2-macroglobulin-like nature. Paper-4612500.
Activation of surface-bound Hageman factor: pre-eminent role of high molecular weight kininogen and evidence for a new factor. Paper-2624149.
Binding and dissociation of Hageman factor, prekallikrein and high molecular weight kininogen in human plasma during contact activation. Paper-3658692.
These two different reaction processes are considered to be linked by the release of plasminogen activator and/or Hageman factor activating enzyme. Paper-4777994.
The role of prekallikrein and high-molecular-weight kininogen in the contact activation of Hageman factor (factor XII) by sulfatides and other agents. Paper-4487869.
Rapid fibrinolysis, augmented Hageman factor (factor XII) titers, and decreased C1 esterase inhibitor titers in women taking oral contraceptives. Paper-3462583.
Glomerular localization of Hageman factor and fibrin-related antigen (FRA) was examined in 31 cases of IgA nephropathy by immunofluorescent techniques. Paper-4597051.
These observations suggest a relationship between MoAb F12 and the autoimmune response characterizing paraneoplastic pemphigus patients' sera. Paper-7664549.
Distal cultures undergo extensive chondrogenesis whether in F12 medium supplemented with 10% fetal calf serum, 5% fetal calf serum, or fibronectin. Paper-4594335.
In addition, the IIF and IIEM staining patterns of MoAb F12 were similar to those observed with sera from two patients with paraneoplastic pemphigus. Paper-7664549.
In this study beta 2-glycoprotein I inhibited the kaolin- induced generation of clot- promoting properties in solutions of Hageman factor. Paper-5898686.
HMW-kininogen is also therefore a cofactor for HF activation, but its effect on HF activation is indirect because it occurs via kallikrein formation. Paper-4488292.
Transforming growth factor-β1 induces expression of human coagulation factor XII via Smad3 and JNK signaling pathways in human lung fibroblasts. Paper-14695417.
Toxic granulomas produced by metals may be caused by C3 being split by plasmin after conversion from plasminogen by activation of the Hageman factor. Paper-3839801.
The effect of nine common polymorphisms in coagulation factor genes ( F2, F5, F7, F12 and F13 ) on the effectiveness of statins: the GenHAT study. Paper-13751128.
Plasma levels of HF, PKK, and HMwK and both immunochemical levels and functional activities of AT III were significantly lower in the septic shock patients. Paper-4124219.
Within the first day after trauma significantly reduced values were found for plasma prekallikrein (PKK), Hageman factor ( HF) and Antithrombin III (AT III). Paper-4485796.
This property in HUVEC lysates could be neutralized by a purified preparation of Hageman factor but not by purified prekallikrein or high molecular mass kininogen. Paper-7565576.
Studies on Hageman factor, plasma prekallikrein, kallikrein "like" activity and kallikrein inhibition in plasma samples from normal subjects and clinical material. Paper-4485800.
METHODS: We screened the coding regions of F12 and the gene encoding membrane-bound APP ( XPNPEP2), for genetic variants in the 3 affected female subjects. Paper-13705728.
Human coagulation factor XI has been purified, and upon activation with Hageman factor fragments, was found to convert the fibrinolytic proenzyme plasminogen to plasmin. Paper-3325699.
Two children with bleeding disorders (factor VIII [ antihemophilic factor] and factor XII [ Hageman factor] deficiency) did not require packed red blood cells transfusion. Paper-6729400.
The mechanisms by which human high molecular weight kininogen (HMKrK) contributes to the surface-dependent activation of the Hageman factor systems have been studied. Paper-2627086.
Initiation of the intrinsic coagulation and fibrinolytic pathways of man: the role of surfaces, hageman factor, prekallikrein, high molecular weight kininogen, and factor XI. Paper-3142465.
Complement components are activated by immunologic and non-immunologic mechanisms through various plasma protein systems such as immunoglobulins, properdin, plasmin, thrombin and Hageman factor. Paper-2686894.
No defect in cytotaxin formation could be demonstrated in Hageman factor-deficient plasma, nor did kallikrein inhibitor interfere with the chemotactic activity of normal immune complex-activated human plasma. Paper-2885393.
Further, beta 2-glycoprotein inhibited the generation of amidolytic activity against H-D-prolyl-L-phenylalanyl-L-arginine p-nitroanilide dihydrochloride in mixtures of Hageman factor and ellagic acid. Paper-5898686.
The parameters measured included Hageman factor ( HF), prekallikrein (PKK), high molecular weight kininogen ( HMwK), antithrombin III (AT III), fibrinogen (Fg) and fibrin(ogen) degradation products (FDP's). Paper-4124219.
C1 inhibitor ( C1INH), the major plasma inhibitor of activated C1, kallikrein, and activated Hageman factor, may be an important factor in limiting inflammatory injury mediated by the complement and contact systems. Paper-6604550.
Our data demonstrate that the catalytic domains of MMP-8, MMP-12, MMP-13, and MMP-14 can proteolytically process fibrinogen and, with the exception of MMP-8, also inactivate Factor XII ( Hageman factor). Paper-8654649.
The reactivity of MAb Me14/D12, which identifies the intercellular adhesion molecule ICAM-1 and MAb Mel14/ F12, directed against a 40-kDa molecule, was found to be independent of the Breslow thickness of primary melanomas. Paper-7211648.
Three sera blocked F12 reactivity; two were from paraneoplastic pemphigus patients and the other was from the pemphigus vulgaris patient whose peripheral blood lymphocytes were used to make F12. Paper-7664549.
LMP2- F12 calculations on molecules of chemical interest involving up to 80 atoms, 200 correlated electrons, and 2600 contracted Gaussian-type orbitals, as well as several reactions of large biochemical molecules are reported. Paper-13610787.
No change in TAME esterase or renin activity occurred after addition of kaolin to acid-treated plasma deficient in Hageman factor; however, both enzymatic activities increased slightly in acidified prekallikrein-deficient plasma. Paper-3717486.
The roles of HMW-kininogen, Hageman factor (HF, Factor XII), plasma prekallikrein (Fletcher factor), and plasma thromboplastin antecedent ( PTA, Factor XI) in blood coagulation were studied in a purified system. Paper-2884226.
MAbs F12 and F15, both IgG3k, induced human complement-mediated cytolysis of 3 Fuc-GM1-expressing tumor cell lines: one rat hepatoma cell line, H4-II-E, and 2 human SCLC cell lines, NC1 H69 and NC1 H128. Paper-7170497.
Three out of 6 MoAbs (C9, F12 and H10) reacted only with the cytoplasmic components of A. fumigatus while the remaining three ( B12, F6G5 and D6E6) showed reactivity to both cytoplasm and cell wall of the conidia and hyphae. Paper-7425486.
Indirect immunoelectron microscopy (IIEM) analysis showed that MoAb F12 bound to a component common to desmosomal and hemidesmosomal plaques and to zona adherens-type junctions between hepatocytes and bile duct cells. Paper-7664549.
This study demonstrates that prekallikrein and high-molecular-weight kininogen are physically associated in plasma as a noncovalently linked complex and may therefore be adsorbed together during surface activation of Hageman factor. Paper-2627107.
Low levels of Hageman factor, prekallikrein, and high molecular weight kininogen, together with significantly reduced concentrations of alpha 2-macroglobulin, were observed during septic shock both in patients who died and in the survivors. Paper-3662030.
Hageman factor (HF, factor XII), adsorbed to negatively charged agents, is transformed to an activated state in which it initiates reactions of the intrinsic pathway of thrombin formation by activating plasma thromboplastin antecedent ( PTA, factor XI). Paper-4487869.
These experiments showed that Df-proteinase could activate all the steps of the kinin-generating cascade, i.e., HF, PK and HMWK, and that Df-proteinase retained proteolytic activity even in the presence of an excess amount of endogenous proteinase inhibitors in plasma. Paper-7007793.
We conducted a genome-wide association study for aPTT and identified significant associations with SNPs in three coagulation cascade genes, F12 (rs2731672, combined p = 2.16 x 10(-30)), KNG1 (rs710446, combined p = 9.52 x 10(-22)), and HRG (rs9898, combined p = 1.34 x 10(-11)). Paper-15232576.
The most commonly produced arylamidases active against substrates employed for testing human blood clotting cascade were activated protein C(Ca)-like, activated factor X(Xa)-like and Hageman factor-like followed by kallikrein-like and chymotrypsin-like enzymes.(ABSTRACT TRUNCATED AT 250 WORDS) Paper-191159.
DESIGN AND METHODS: We develop a rapid and feasible asymmetric multiplex real-time PCR-based method using fluorescence resonance emission transfer (FRET) probes followed by a melting temperature (T(m)) curve assay for the simultaneous clinical diagnosis of F2, F5 and F12 mutations in a 10 microl closed tube. Paper-14546684.
The activation of the kinin cascade by Df-proteinase was examined in vitro by using purified guinea pig Hageman factor ( HF), prekallikrein (PK) and high-molecular-weight kininogen ( HMWK) and the effect of this proteinase on endogenous human plasma proteinase inhibitors (serpins) and alpha 2-macroglobulin was tested. Paper-7007793.
The Hageman factor dependent pathways are influenced by several control proteins which modulate the extent of activation and biologic activity of these enzyme substrates (Fig. 1). C1 INH plays a prominent role by acting at the common initiating step for all three Hageman factor dependent systems and its deficiency produces disease in man. Paper-2646859.
RESEARCH DESIGN AND METHODS: We enrolled 3,094 Japanese type 2 diabetic subjects (62.7% male; aged 61.5 +/- 8.4 years) and determined their genotypes regarding matrix metalloproteinase 9 C-1562T, coagulation factor XII ( F12) C46T, von Willebrand factor ( VWF) G-1051A, and plasminogen activator inhibitor ( PAI-1) 675 4G/5G polymorphisms. Paper-14221238.
D10 and F12 clones substantially differ in terms of protein pattern; that is, D10 is super-imposable to infected HUT-78 cells, whereas F12 exhibits a decreased uncleaved p55 gag precursor and the presence of uncleaved gp160 and of a unique p19, although they do not show qualitative or quantitative differences in viral RNA synthesis. Paper-6202885.
These synonyms are used for gene F12 (coagulation factor XII (Hageman factor)): Hageman factor, HAF, HAEX, HAE3, Coagulation factor XII.
These accession numbers are used for gene F12: P78341 (UNIPROT__AC), P78339 (UNIPROT__AC), M11723 (NCBI_GENBANK__AC), BT007350 (NCBI_GENBANK__AC).
F12 is a homologue of F12 (coagulation factor XII (Hageman factor)) from Pan troglodytes.
F12 is a homologue of F12 (coagulation factor XII (Hageman factor)) from Canis lupus familiaris.
F12 is a homologue of F12 (coagulation factor XII (Hageman factor)) from Bos taurus.
F12 is a homologue of F12 (coagulation factor XII-like) from Bos taurus.
F12 is a homologue of F12 (coagulation factor XII (Hageman factor)) from Mus musculus.
F12 is a homologue of F12 (coagulation factor XII (Hageman factor)) from Rattus norvegicus.
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iHOP - Information Hyperlinked over Proteins .
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