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GRM7 variants confer susceptibility to age-related hearing impairment. Paper-13513805.
Interaction between metabotropic glutamate receptor 7 and alpha tubulin. Paper-9432116.
On the basis of previous biological evidence, we consider GRM7 a strong MDD candidate gene. Paper-15640909.
Finally, co-expression of Filamin-A and mGluR7 splice variants was shown in brain regions. Paper-9427882.
The genes encoded by frequently lost clones were PTPRG, GRM7, ZDHHC3, EXOSC7, LRP1B, and NR3C2. Paper-13242539.
We selected 8 and 43 common SNPs distributed in the entire gene regions of GRM4 (>111 kb) and GRM7 (>900 kb), respectively. Paper-13733631.
Domain mapping revealed that alternative splicing of mGluR4, mGluR7 and mGluR8 C-termini regulated the interaction. Paper-9427882.
Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia. Paper-13733631.
Here, we describe the interaction of mGluR7, a group-III mGluR and presynaptic autoreceptor, with the cytoskeletal protein, alpha tubulin. Paper-9432116.
The antagonist potency of the purported group III mGluR antagonist MPPG also varied among the receptors being human mGluR8 >> mGluR4 = mGluR7. Paper-1375329.
Here we report association studies of schizophrenia with polymorphisms in group III metabotropic glutamate receptor genes, GRM4 and GRM7. Paper-13733631.
These studies yielded a single prominent mGluR7 CT-associated protein of 55 kDa, which subsequent microsequencing analysis revealed to be alpha tubulin. Paper-9432116.
Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/ orphanin FQ receptor and panic disorder. Paper-12376336.
As a previous GWAS of a European and Finnish sample set already suggested a role for GRM7 in ARHI, this study provides further evidence for the involvement of this gene. Paper-15120403.
Complementary DNAs (cDNAs) encoding the human mGluR4, human mGluR7, and human mGluR8 were isolated from human cerebellum, fetal brain or retinal cDNA libraries. Paper-1375329.
We show a relationship between these three proteins using recombinant PICK1, mGluR7, and PKCalpha, where they were co-immunoprecipitated as a complex from COS-7 cells. Paper-8630203.
The strongest evidence for association in the meta-analysis was observed for intronic SNPs in ATP6V1B2 (P=6.78 x 10⁻⁷), SP4 (P=7.68 x 10⁻⁷) and GRM7 (P=1.11 x 10⁻⁶). Paper-15640909.
The nucleotide and amino acid sequences in the coding region of human mGluR4 and mGluR7 were found to be identical to the previously published sequences by Flor et al. and Makoff et al. Paper-1375329.
The human mGluR4 and mGluR7 had amino acid identity of 96% and 99.5% with rat mGluR4 and 7, respectively, whereas the human mGluR8 has 98.8% amino acid identity with the mouse mGluR8. Paper-1375329.
The reported group II mGluR agonist L-CCG-I was a highly potent mGluR8 agonist (EC50=0.35 microM), with significant agonist activities at both mGluR4 (EC50=3.7 microM) and mGluR7 (EC50=47 microM). Paper-1375329.
Coimmunoprecipitation assays confirmed that full-length mGluR7 and alpha tubulin interact in rat brain as well as in BHK cells stably expressing mGluR7a, a splice variant of mGluR7. Paper-9432116.
We conclude that at least one susceptibility locus for schizophrenia is located within or nearby GRM7, whereas GRM4 is unlikely to be a major susceptibility gene for schizophrenia in the Japanese population. Paper-13733631.
Together these data indicate that common alleles of GRM7 contribute to an individual's risk of developing ARHI, possibly through a mechanism of altered susceptibility to glutamate excitotoxicity. Paper-13513805.
The human mGluR4, mGluR7 and mGluR8 receptors were 912, 915 and 908 amino acid residues long and share 67-70% amino acid similarity with each other and 42-45% similarity with the members of mGluR subgroups I and II. Paper-1375329.
Indeed, deletion mutagenesis experiments revealed that the alpha tubulin- binding site is located within amino acids 873-892 of the mGluR7 CT domain, a region known to be important for regulation of mGluR7 trafficking. Paper-9432116.
A total of 182 patients meeting DSM-IV alcohol dependence criteria and 117 controls, both groups being of German descent, were investigated. mGluR7 and mGluR8 polymorphisms were determined using polymerase chain reaction of lymphocyte DNA. Paper-9410558.
These data suggest that the mGluR7/ alpha tubulin interaction may provide a mechanism to control access of the CT domain to regulatory molecules, or alternatively, that this interaction may lead to morphological changes in the presynaptic membrane in response to receptor activation. Paper-9432116.
These synonyms are used for gene GRM7 (glutamate receptor, metabotropic 7): MGLUR7, mGluR7, MGLU7, mGlu7, Metabotropic glutamate receptor 7, GPRC1G, GLUR7, FLJ40498.
These accession numbers are used for gene GRM7: X94552 (NCBI_GENBANK__AC), Q8NFS4 (UNIPROT__AC), Q8NFS3 (UNIPROT__AC), BC136458 (NCBI_GENBANK__AC).
GRM7 is a homologue of LOC568484 (glutamate receptor, metabotropic) from Danio rerio.
GRM7 is a homologue of grma (glutamate receptor, metabotropic a) from Danio rerio.
GRM7 is a homologue of GRM7 (glutamate receptor, metabotropic 7) from Pan troglodytes.
GRM7 is a homologue of GRM7 (glutamate receptor, metabotropic 7) from Canis lupus familiaris.
GRM7 is a homologue of GRM7 (glutamate receptor, metabotropic 7) from Bos taurus.
GRM7 is a homologue of GRM7 (glutamate receptor, metabotropic 7) from Gallus gallus.
GRM7 is a homologue of Grm7 (glutamate receptor, metabotropic 7) from Mus musculus.
GRM7 is a homologue of Grm7 (glutamate receptor, metabotropic 7) from Rattus norvegicus.
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