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E-cadherin-directed signaling increased HOXA1 expression through Rac1. Paper-11309798.
Pure partial 7p trisomy including the TWIST, HOXA, and GLI3 genes. Paper-8807420.
No association between HOXA1 and HOXB1 genes and autism spectrum disorders (ASD). Paper-9559470.
Lack of association of HOXA1 and HOXB1 variants with autism in the Indian population. Paper-13095424.
Three loci were precisely localized in 7p15.3 ( HOXA@), 17q21.3 ( HOXB@) and 12q13.3 (HOXC@). Paper-562286.
Lack of association of HOXA1 and HOXB1 mutations and autism in Sicilian (Italian) patients. Paper-9942975.
Here, we also show an interaction between variants of HOXA1 and one of the HOX protein known cofactors, PBX1. Paper-12444306.
Discovery of allelic variants of HOXA1 and HOXB1: genetic susceptibility to autism spectrum disorders. Paper-8646541.
HOXA1 is required for E-cadherin-dependent anchorage-independent survival of human mammary carcinoma cells. Paper-11309798.
We have found that many CpG islands at the HOXA and HOXD loci were methylated in human lung adenocarcinoma. Paper-9470459.
Expanded HOXA1 variants exhibited reduced PBX1-coupled transcriptional activity through a regulatory enhancer of HOXB1. Paper-12444306.
RESULTS: Novel deletions and insertions of coding trinucleotide repeats were found in the DLX2, HOXA1, and FOXP2 genes. Paper-14478852.
Expression of Hoxa genes is reduced in cells differentiating as a result of MLL- ENL loss, but is maintained in G-CSF treated cells. Paper-11368195.
HOXA cluster deregulation in T-ALL associated with both a TCRD- HOXA and a CALM-AF10 chromosomal translocation. Paper-12111598.
HOXB1 provides minor, albeit detectable contributions to head circumference in autistic patients, with HOXA1 displaying more prominent effects. Paper-15327864.
The human IGFBP-1 and IGFBP-3 genes are contiguous and located in close proximity to the homeobox A ( HOXA) gene cluster on chromosome 7. Paper-1246508.
An initial report, suggesting that HOXB1 could confer autism vulnerability in interaction with HOXA1, was not confirmed by five small association studies. Paper-15327864.
HOXA1 is therefore a downstream effector of E-cadherin-directed signaling required for anchorage-independent proliferation of mammary carcinoma cells. Paper-11309798.
ABSTRACT: BACKGROUND: HOXB1 plays a major role in brainstem morphogenesis and could partly determine the cranial circumference in conjunction with HOXA1. Paper-15327864.
We provide examples of correlation of computational predictions to reported mapped DNase I hypersensitive segments in the HOXA locus in human chromosome 7. Paper-13664838.
Continued maintenance of this MLL-dependent Hoxa gene expression profile is associated with conditional MLL-associated myeloid immortalization. Paper-9997946.
Enhanced autophagic cell death in expanded polyhistidine variants of HOXA1 reduces PBX1-coupled transcriptional activity and inhibits neuronal differentiation. Paper-12444306.
Genes required for FRT development include Pax2, Lim1 and Emx2, genes in the abdominal-B Hoxa cluster, and members of both Wnt and Hedgehog (Hh) gene families. Paper-12154021.
The protein levels of STAT3 and 5B, but not STAT5A, and protein phosphorylation levels of STAT3 and 5B were significantly increased by forced expression of HOXA1. Paper-12762739.
We report here that autocrine hGH production by human mammary carcinoma cells increased the expression and transcriptional activity of the homeobox domain containing protein HOXA1. Paper-9844435.
HOXA1, the most telomeric of the 13 members of the HOXA gene cluster, is located at the centromeric boundary of the patient's chromosome 7 deletion. Paper-9663952.
METHODOLOGY/PRINCIPAL FINDINGS: Phylogenetic analyses of 18 Hox-related genes from Nematostella identify putative Hox1, Hox2, and Hox9+ genes. Paper-12438221.
A cluster of homeobox-containing genes ( HOXA) and a heterogeneous nuclear ribonucleoprotein (hnRPA2B1) have both previously been assigned to chromosome 7p15 by in situ hybridization. Paper-1049196.
These results suggest that HOXA1 partially mediates oncogenic transformation of the immortalized human mammary epithelial cell through modulation of the STAT3 and STAT5B pathways. Paper-12762739.
Genetic studies have reported an association between autism and DLX2, HOXA1, EN2, ARX, and FOXP2 genes whereas only three studies of EN2, OTX2, and FOXP2 were performed on schizophrenia. Paper-14478852.
METHODS: By sequencing regions of genomic DNA of patients with autism spectrum disorders, we detected a substitution variant at HOXA1 and an insertion variant at HOXB1, both in coding regions of the genes. Paper-8646541.
These results provide further evidence that expanded polyhistidine repeats in HOXA1 enhance aggregation and cell death, resulting in impaired neuronal differentiation and cooperative binding with PBX1. Paper-12444306.
No statistically significant effects were detected when the same analyses were applied to the HOXB1 locus, but there was evidence of an interaction between HOXA1, HOXB1, and gender in susceptibility to ASDs. Paper-8646541.
CONCLUSION: This study did not identify specific disease risk variants of trinucleotide repeats in OTX1, EN1, DLX2, HOXA1, and FOXP2 candidate genes in neurodevelopmental psychiatric disorders. Paper-14478852.
Increased HOXA1 expression consequent to E-cadherin-activated signaling decreased apoptotic cell death and was required for E-cadherin-dependent anchorage-independent proliferation of human mammary carcinoma cells. Paper-11309798.
Mice with null mutations of Hoxa1 or Hoxb1, two genes critical to hindbrain development, have phenotypic features frequently observed in autism, but no naturally occurring variants of either gene have been identified in mammals. Paper-8646541.
Transcriptional activation of signal transducer and activator of transcription (STAT) 3 and STAT5B partially mediate homeobox A1-stimulated oncogenic transformation of the immortalized human mammary epithelial cell. Paper-12762739.
Increased HOXA1 expression at full confluence was prevented by an E-cadherin function- blocking antibody and attachment of non-confluent cells to a substrate by homophilic ligation of E-cadherin increased HOXA1 expression. Paper-11309798.
Furthermore, we identified a homozygous deletion of beta-catenin in the mesothelioma, NCI-H28, associated with reduced WNT7a and the lowest overall cell line expression of HOXA1, HOXA7, HOXA9, and HOXA10, whereas HOXB9 levels were unaffected. Paper-8576816.
The four most highly ranked loci, CDKN2A EX2, CDX2, HOXA1 and OPCML, which show significant DNA methylation even in stage IA tumor samples, merit further investigation as some of the most promising lung adenocarcinoma markers identified to date. Paper-13443752.
Using the current tissue collection and 5-fold cross validation, the four most significant loci ( CDKN2A EX2, CDX2, HOXA1 and OPCML) individually distinguish lung adenocarcinoma from non-cancer lung with a sensitivity of 67-86% and specificity of 74-82%. Paper-13443752.
Thus, although aberrant maintenance of Hoxa gene expression may play an important role in MLL- ENL induced leukemia, the contribution of this pathway to immortalization is critically dependent on the cytokine environment of the immortalized myeloid cells. Paper-11368195.
We demonstrate here that primary myeloid progenitors immortalized by various MLL oncoproteins exhibit a characteristic Hoxa gene cluster expression profile, which reflects that preferentially expressed in the myeloid clonogenic progenitor fraction of normal bone marrow. Paper-9997946.
The analysis of multiple null mutants generated through targeted disruption indicates that the 5' members of the Hoxd and Hoxa clusters determine the skeletal pattern in the limb by regulating the formation and growth of the different chondrogenic precursors for the skeletal elements. Paper-1827514.
To construct the PAC and cosmid contig map spanning the HOXA cluster on human chromosome 7, we used 9 DNA markers (D7S2243, D7S3010, HOXA1, EVX1, 750, pBH8, p60, p8.0, and HOXA11), among which the final 4 were generated in this study by shotgun cloning strategy. Paper-1920173.
This review discusses the normal structure and function of CALM and AF10, describes the spectrum of clinical findings seen in patients with CALM-AF10 fusions, summarizes recently published CALM-AF10 mouse models and highlights the role of HOXA cluster gene activation in CALM-AF10 leukemia. Paper-12782476.
Accordingly, inhibition of STAT3 or STAT5B activity with dominant negative STAT3 or STAT5B abrogated the ability of HOXA1 to stimulate cell proliferation, survival, oncogenic transformation, and generation of large disorganized multiacinar structures in three-dimensional culture. Paper-12762739.
RESULTS: We identified thirteen loci showing significant differential DNA methylation levels between tumor and non-tumor lung; eight of these show highly significant hypermethylation in adenocarcinoma: CDH13, CDKN2A EX2, CDX2, HOXA1, OPCML, RASSF1, SFPR1, and TWIST1 (p-value << 0.0001). Paper-13443752.
We are discovering that these disorders result from mutations in genes necessary for the normal development and connectivity of brainstem ocular motoneurons, including PHOX2A, SALL4, KIF21A, ROBO3, and HOXA1, and we now refer to these syndromes as the "congenital cranial dysinnervation disorders," or CCDD. Paper-11363302.
METHODS: We screened the coding trinucleotide repeats of OTX1, EN1, DLX2, HOXA1, and FOXP2 genes in populations suffering from schizophrenia (247 patients), autism (98 patients), and idiopathic mental retardation (56 patients), and compared them with control populations (112 super controls and 202 healthy controls). Paper-14478852.
These synonyms are used for gene HOXA1 (homeobox A1): MGC45232, HOX1F, HOX1, Homeobox protein Hox-A1, Homeobox protein Hox-1F, BSAS.
These accession numbers are used for gene HOXA1: DQ894038 (NCBI_GENBANK__AC), B2R8U7 (UNIPROT__AC), AK308067 (NCBI_GENBANK__AC), A4D184 (UNIPROT__AC).
HOXA1 is a homologue of hoxa1a (homeo box A1a) from Danio rerio.
HOXA1 is a homologue of HOXA1 (homeobox A1) from Canis lupus familiaris.
HOXA1 is a homologue of HOXA1 (homeobox A1) from Bos taurus.
HOXA1 is a homologue of HOXA1 (homeobox A1) from Pan troglodytes.
HOXA1 is a homologue of Hoxa1 (homeobox A1) from Mus musculus.
HOXA1 is a homologue of Hoxa1 (homeo box A1) from Rattus norvegicus.
HOXA1 is a homologue of ceh-13 (Homeobox) from Caenorhabditis elegans.
Important links !
iHOP - Information Hyperlinked over Proteins .
Concept & Implementation by Robert Hoffmann.