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RESULTS: MoDCs express both H1R and H2R. Paper-9404578.
Hyper-IgE syndrome and H2-receptor blockade. Paper-6439721.
Finally, K44E dynamin did not affect ERK1/2 activation induced by internalization-deficient H2R. Paper-12956429.
Histamine and H1R and H2R agonists downregulated IL-12p70 production of prestimulated MoDCs. Paper-9404578.
In this model, animals were treated with human gastrin, XPA067.06, and H2R or M1 receptor antagonists. Paper-12880005.
Our results show that histamine enhances melanoma growth via H1R rather than through H2R. Paper-14368897.
Furthermore, ERK1/2 activation via H2R is likely dependent of the endocytotic process rather than dynamin itself. Paper-12956429.
HaCaT KCs and normal human KCs (NHKs) predominantly expressed histamine H1 receptor ( H1R) and H2 receptor ( H2R). Paper-15771854.
These results suggest that the agonist-induced H2R internalization and ERK1/2 activation are partially dynamin-dependent. Paper-12956429.
Proton-pump inhibitors or H2-receptor antagonists for Helicobacter pylori eradication-a meta-analysis. Paper-517359.
These options include the proton pump inhibitors, misoprostil, double-dose H2-receptor blockers and the COX-2 selective NSAIDs. Paper-10683266.
In the present study, we demonstrate that H1R, H2R and H4R are expressed in colon carcinoma and the adjacent normal mucosa. Paper-12774371.
We hypothesized that SAR subjects express higher nasal mucosal histamine receptor 1 ( H1R) and 2 ( H2R) levels than do NR subjects. Paper-9899807.
METHODS: Expression of histamine H1 and H2 receptors ( H1R and H2R) on MoDCs was assessed by means of RT-PCR and flow cytometry. Paper-9404578.
Furthermore, activation of extracellular-signal regulated kinases ERK1/2 in response to dimaprit, an H2R agonist, was attenuated by K44E-dynamin. Paper-12956429.
Immunohistochemical staining revealed expression patterns of H1R, H2R and H4R similar to those suggested by the mRNA and Western blot results. Paper-12774371.
Proton pump inhibitors produce a greater and longer-lasting degree of suppression of acidity than conventional doses of H2-receptor antagonists. Paper-165070.
CONCLUSIONS: There were no significant differences in H1R or H2R mRNA levels between SAR and NR subjects in-season, despite observed differences in H reactivity. Paper-9899807.
In addition, the H1R antagonist olopatadine significantly blocked histamine-induced production of IL-6, whereas the H2R antagonist ranitidine did not. Paper-14658679.
Three impromidine analogues and six arpromidine analogues exhibited agonistic activity at H2R and antagonistic activity at H1R as assessed in the steady-state GTPase assay. Paper-13177385.
RESULTS: Reverse transcription-polymerase chain reaction and Western blotting revealed expression of histamine H1 receptor ( H1R) and H2 receptor ( H2R) in human amnion. Paper-14658679.
A prospective, open, multicenter clinical trial was set up to evaluate the potential interaction of ITF 282 with H2-receptor antagonists in patients affected with iron deficiency. Paper-7588162.
The purpose of this study was to examine structure-activity relationships of guanidines at human and guinea pig H1R and H2R species isoforms expressed in Sf9 insect cells. Paper-13177385.
Real-time RT-PCR results revealed significantly decreased (p<0.001) H1R and H4R mRNA levels in tumours compared to normal colonic mucosa, without any significant change in H2R mRNA expression. Paper-12774371.
The biogenic amine histamine, acting via H2-type histamine receptors ( H2R) on monocytes, completely counteracted the monocyte-mediated suppression of IL-2-induced NK-cell proliferation. Paper-6923353.
In this study, we examined the effects of NG-acylated imidazolylpropylguanidines substituted with a single phenyl or cyclohexyl substituent on H1R and H2R species isoforms expressed in Sf9 insect cells. Paper-11993261.
The ratio of relative gene copy numbers between the SAR and NR groups were as follows: H1R, 0.85 ( P = 0.52); H2R, 0.67 ( P = 0.35); EGF, 1.02 ( P = 0.93), and EGFR, 103.5 ( P < 0.05). Paper-9899807.
As shown previously, native or recombinant (r) human platelet factor 4 ( PF4) alleviates the suppression induced by Con A or dimaprit, a histamine type 2 receptor ( H2-R) agonist, in a murine system. Paper-727235.
No significant differences were observed in allele and genotype frequencies, and haplotype frequencies of all the SNPs of FCER1B, HNMT, HRH1, and HRH2 among the three groups (p>0.05, respectively). Paper-11262317.
Although H2R with truncation of 51 amino acids at its carboxy-terminus did not internalize after agonist stimulation, it still activated ERK1/2, but the degree of this activation was less than that of the wild-type receptor. Paper-12956429.
Functional exploration of these receptors was performed by monitoring the increase of intracellular calcium levels ( H1R), cyclic adenosine monophosphate formation ( H2R), F-actin polymerization, and IL-12p70 production. Paper-9404578.
In Part II, drugs used in the management of peptic ulcer disease (antacids, H-2 receptor and proton pump antagonists), pancreatic enzymes, prokinetic agents, and drugs used with inflammatory bowel disease are described. Paper-7674366.
We report a high-throughput method for genotyping of single nucleotide polymorphisms ( SNPs) within the genes of histamine H2 receptor ( HRH2), serotonin receptor (HTR2A1 and HTR2A2), and beta(3) adrenergic receptor ( ADRB3). Paper-13557949.
Our data indicate that it is difficult to obtain guanidine-type agonists with high potency and high efficacy for hH2R, but those compounds may be useful tools for exploring the antagonist binding site and constitutive activity of H1R. Paper-13177385.
This study evaluates the event rates for all NSAID-induced GI complications in patients with rheumatoid arthritis, describes the time course of these events, and evaluates the role of prophylactic therapy with antacids and H2 receptor antagonists. Paper-597833.
Agonist stimulation of H2R results in several cellular events including activation of adenylate cyclase and phospholipase C, desensitization of the receptor, activation of extracellular signal-regulated kinases ERK1/2, and receptor endocytosis. Paper-12956429.
In the present study we investigated whether the histamine H2 receptor ( H2R), a Gα(s)-coupled GPCR known to be desensitized by GRK2, needs to be phosphorylated for its desensitization and/or internalization and resensitization. Paper-16150440.
Because many patients will not achieve complete relief from OTC products, clinicians will be required to rethink treatment strategies for those who present with persistent reflux symptoms after a trial of low dose H2 receptor antagonists or other antisecretories. Paper-8854331.
ITF 282 resulted, also when administered together with H2-receptor antagonists, in the expected therapeutic efficacy, with the expected clinical tolerability and biological safety, without signs of possible interaction, negative or positive.(ABSTRACT TRUNCATED AT 250 WORDS) Paper-7588162.
Both the histamine H1-receptor ( H1R) and H2-receptor ( H2R) exhibit pronounced species selectivity in their pharmacological properties; i.e., bulky agonists possess higher potencies and efficacies at guinea pig (gp) than at the corresponding human (h) receptor isoforms. Paper-11993261.
A review of the recent literature reveals that clinical studies of both classic and new nonsedating H1-receptor antagonists, H2-receptor antagonists, a variety of intranasal medications, and mast-cell stabilizers demonstrate variable roles in the management of these diseases. Paper-7961411.
Collectively, our data show that gpH1R and gpH R do not necessarily exhibit preference for bulky agonists (2) compared with hH1R and hH2R, respectively, and that UR-AK57 is a promising starting point for the development of both potent and efficacious hH1R and hH2R agonists. Paper-11993261.
Although histidine decarboxylase mRNA levels did not change with age in C57BL/6 mice, significant differences were found in histamine H1 receptor ( H1R), histamine H2 receptor ( H2R), and histamine H3 receptor ( H3R) mRNA levels in several brain regions. Paper-10341574.
This histamine effect on LOX-1 gene expression, via the histamine H2 receptor-mediated cAMP signal transduction pathway, was reduced after differentiation of the cells into macrophages, even though forskolin and Bt2-cAMP still enhanced the gene expression. Paper-9098462.
Regulation of histamine-coupled genes was investigated by checking the presence and functional integrity of all four known histamine receptors in experimental melanomas and by administering histamine H1 receptor ( H1R) and H2 receptor ( H2R) antagonists to tumor-bearing mice. Paper-14368897.
Proton pump inhibitors are considered the best choice for the management of grades II-IV oesophagitis and are more cost-effective than H2-receptor antagonists because of their fast healing of oesophagitis, early relief of symptoms, and prevention of recurrent oesophagitis and development of complications. Paper-906279.
We also found that the cimetidine-mediated down-regulation of NCAM expression in HSG cells did not occur via blocking of the histamine receptor, even though H2R expression was observed on HSG cells, as two other H2R antagonists, famotidine and ranitidine, did not show similar effects. Paper-12449817.
On the other hand, we show that engagement of H2R also reduces intracellular protein pools of IGF-IIR and FBLN5, but being a downstream acting posttranslational effect with minimal consequences on exported IGF-IIR and FBLN5 protein levels, H2R is rather irrelevant compared with H1R in melanoma. Paper-14368897.
Eleven single nucleotide polymorphisms ( SNPs) of the beta chain of the high-affinity IgE receptor ( FCER1B) and three histamine-related genes- histamine N-methyltransferase ( HNMT), histamine H1 receptor ( HRH1), histamine H2 receptor (HRH2)-were screened using the SNP-IT assay based on a single base extension method. Paper-11262317.
These synonyms are used for gene HRH2 (histamine receptor H2): Histamine H2 receptor, HH2R, H2R, Gastric receptor I.
These accession numbers are used for gene HRH2: Q14464 (UNIPROT__AC), B5BUP7 (UNIPROT__AC), AY136744 (NCBI_GENBANK__AC), AB451483 (NCBI_GENBANK__AC).
HRH2 is a homologue of HRH2 (histamine receptor H2) from Gallus gallus.
HRH2 is a homologue of HRH2 (histamine receptor H2) from Pan troglodytes.
HRH2 is a homologue of HRH2 (histamine receptor H2) from Canis lupus familiaris.
HRH2 is a homologue of HRH2 (histamine receptor H2) from Bos taurus.
HRH2 is a homologue of Hrh2 (histamine receptor H2) from Mus musculus.
HRH2 is a homologue of Hrh2 (histamine receptor H 2) from Rattus norvegicus.
HRH2 is a homologue of hrh2 (histamine receptor H2) from Danio rerio.
Important links !
iHOP - Information Hyperlinked over Proteins .
Concept & Implementation by Robert Hoffmann.