Click here for the function of HRH2.
Hyper-IgE syndrome and H2-receptor blockade. Paper-6439721.
Prolactin responses to histamine H2 receptor antagonists. Paper-3649278.
H2R and beta-actin mRNA were amplified by RT-PCR. Paper-1854170.
H4R or H2R stimulation suppressed IL-12p70 production in MoDC. Paper-10801253.
Effect of histamine H2-receptor antagonists on vitamin B12 absorption. Paper-7216693.
Histamine H2 receptor blockade in patients with hyperparathyroidism. Paper-4803388.
VIP and histamine H2 receptor activity in human fetal gastric glands. Paper-5403164.
Recently, H1- and H2-receptor genes have been cloned in various animal species. Paper-8077794.
Epithelial cells also expressed H1R, H2R and, to some extent, H4R. Paper-11392854.
Immune cells expressed mRNA and protein for H1R, H2R, and low levels of H4R. Paper-11392854.
H2-receptor antagonists are indicated in GOR complicated by esophagitis. Paper-11593416.
H2-receptor antagonists inhibit gastric ADH activity to a variable extent. Paper-1871338.
Histamine H1 and H3 receptor agonists do not show histamine H2 receptor activity. Paper-8123002.
H2R overexpression induced PDE activity stimulation and GRK2 overexpression. Paper-11771574.
The effects of histamine H2-receptor antagonists on PHA induced lymphocyte proliferation. Paper-4669458.
H2 receptor antagonists and an agonist ( impromidine) inhibit intestinal DAO. Paper-4499352.
Neurobehavioral syndrome induced by H2-receptor blocker withdrawal: possible role of prolactin. Paper-963382.
The H2 receptor message was mainly down-regulated by activation of the H1 receptor protein. Paper-8288618.
RT-PCR showed that SW756 expressed mRNA for CB1, CB2, H1R, H2R, and H4R. Paper-12754476.
Histamine increases the expression of LOX-1 via H2 receptor in human monocytic THP-1 cells. Paper-9098462.
This rebound in GH secretion might indicate an inhibitory effect of TRH during H2-receptor stimulation. Paper-4784579.
Proton pump inhibitors are more effective than H2-receptor antagonists in virtually all cases. Paper-11210226.
This may reflect differences in H1 to H2 receptor density or cell responsiveness to receptor stimulation. Paper-2882143.
Efficacy of H2 receptor antagonists in the treatment of gastroesophageal reflux disease and its symptoms. Paper-1227789.
Proton pump inhibitors are more potent inhibitors of acid secretion than H2-receptor antagonists. Paper-786264.
Histamine receptor immunoreactivity ( H1R, H2R, H3R, H4R) was found in situ and in vitro. Paper-12119807.
Effect of H2-receptor antagonists on gastric acid secretion and serum gastrin concentration: a review. Paper-2931657.
Treatment of peptic ulcer in the elderly. Proton pump inhibitors and histamine H2 receptor antagonists. Paper-856192.
Cimetidine, an H2 receptor antagonist, is a potent stimulant of PRL secretion in normal women. Paper-6046887.
H2 receptor antagonists, cytochrome P450, and paracetamol-induced hepatotoxicity. Paper-11932930.
Like other G protein-coupled receptors, exposure of H2r to agonists produces a desensitization of the response. Paper-9070038.
Histamine H2 receptor desensitization: involvement of a select array of G protein-coupled receptor kinases. Paper-9070038.
Effect of histamine H2-receptor stimulation on bombesin- and peptone- stimulated gastrin release in man. Paper-5254446.
Cimetidine and other H2-receptor antagonists as inhibitors of human E3 aldehyde dehydrogenase. Paper-1125122.
This response was reduced by the histamine H2-receptor antagonist ranitidine ( IC50 = 3 X 10(-6) mol/l). Paper-5301253.
It has been reported that cimetidine, an H2-receptor antagonist, stimulates PRL secretion in postpartum. Paper-4870326.
Evaluation of combined H1- and H2-receptor blocking agents in the treatment of seasonal allergic rhinitis. Paper-4250908.
Selective expression of histamine receptors H1R, H2R, and H4R, but not H3R, in the human intestinal tract. Paper-11392854.
Effect of the new H2-receptor antagonist ranitidine on plasma prolactin levels in duodenal ulcer patients. Paper-3922702.
Four- to six-week therapy of H2-receptor antagonist and antacid had no influence on serum gastrin concentrations. Paper-7744707.
Stimulation of postprandial somatostatin release by H2-receptor agonists and prostaglandins has been reported. Paper-5407268.
The effects of histamine H2-receptor antagonists on acetylcholinesterase and pseudocholinesterase activity were studied. Paper-5440527.
Proton-pump inhibitors or H2-receptor antagonists for Helicobacter pylori eradication-a meta-analysis. Paper-517359.
Histamine H2 receptor agonists and antagonists are more potent than drugs acting on H1 receptors ( H2 greater than H1). Paper-5440197.
These results suggest a predominantly H2-receptor mediated phenomenon with a minor H1-receptor mediated component. Paper-5261622.
Chronic beta 1-adrenoceptor blockade sensitises the H1 and H2 receptor systems in human atrium: rôle of cyclic nucleotides. Paper-689867.
H2-receptor blockade induces peptide YY and enteroglucagon-secreting gastric carcinoids in mastomys. Paper-6485901.
Proton pump inhibitors, histamine H2 receptor antagonists, and other antacid medications and the risk of fracture. Paper-12197089.
Long-term effects of histamine H2-receptor antagonists on serum parathyroid hormone in chronic renal failure. Paper-4853290.
This effect was blocked by the H1 receptor antagonist mepyramine but not by the H2 receptor antagonist cimetidine. Paper-6590512.
The recent observation of constitutive H1- and H2-receptor activity has led to a reclassification of H1- and H2-antagonists. Paper-9509055.
In fura-loaded H1- and H2-receptor-expressing cells histamine induced the release of calcium from intracellular stores. Paper-1133782.
H2 receptor antagonist treatment had little effect on tissue type or urokinase type plasminogen activator activity. Paper-7848823.
H2-Receptor antagonists and omeprazole, a H-K ATPase inhibitor, inhibit acid secretion from the parietal cells. Paper-6436952.
Dimaprit analogues inhibit tyrosinase via a disulphide breakdown product independently of the histamine H2 receptor. Paper-8047757.
These options include the proton pump inhibitors, misoprostil, double-dose H2-receptor blockers and the COX-2 selective NSAIDs. Paper-10683266.
The results indicate an effect of H2-receptor antagonists on physiological functions in the control of PRL secretion. Paper-3943129.
The Ki value of the E3 isozyme for cimetidine was the same as the in vitro dissociation constant for the H2-receptor. Paper-1125122.
Histamine H2 receptor mediated dual signaling: mapping of structural requirements using beta2 adrenergic chimeric receptors. Paper-8658154.
Previous reports have suggested that the H2-receptor blocker, cimetidine, can inhibit parathyroid hormone ( PTH) release. Paper-3768031.
Down-regulation of the H1 receptor message seemed to be a net result of H1 and H2 receptor activation. Paper-8288618.
However, H2 receptor antagonist ( ranitidine) and H3/ H4 receptor antagonist ( thioperamide) did not alter this effect. Paper-11333706.
H1 and H2-receptor antagonists have been successfully used for a long time in the treatment of allergy and ulcer, respectively. Paper-8077794.
Proton-pump inhibitors and H2-receptor antagonists accounted for 261 (44.5%) and 307 (52.5%) of prescriptions respectively. Paper-8459805.
The decrease in TNF-alpha production by dimaprit was reversed by cimetidine, a histamine H2 receptor antagonist. Paper-1046626.
Dimaprit--[S-[3-(N,N-dimethylamino)propyl]isothiourea]--a highly specific histamine H2-receptor agonist. Part 1. Pharmacology. 1977. Paper-8217943.
H1 receptor agonist ( betahistine), but not H2 receptor agonist ( amthamine), induced phosphorylation of STAT4. Paper-11333706.
In the present study, we demonstrate that H1R, H2R and H4R are expressed in colon carcinoma and the adjacent normal mucosa. Paper-12774371.
Attenuation of the aggressive gastric juice by anticholinergics and antihistamines of the H2 receptor blocker type and secretin. Paper-2314730.
All H2-receptor antagonists clearly antagonized histamine- induced NKCC enhancement in monocyte-containing effector cells. Paper-5736930.
Furthermore, c-Myc levels decreased following forskolin treatment, while the histamine H2 receptor agonist dimaprit had no effect. Paper-1572589.
RESULTS: We found that H1R, H2R, and H4R mRNA were expressed throughout the gastrointestinal tract, while H3R mRNA was absent. Paper-11392854.
OBJECTIVE: To discuss the potential of histamine H2-receptor antagonists (H2RAs) to cause malabsorption of vitamin B12 (cyanocobalamin). Paper-7216693.
Activation of histamine receptor 1 ( H1R) and 2 ( H2R) can cause allergic symptoms which can be blocked effectively by antihistamines. Paper-11233462.
RESULTS: Proton pump blockers were used by 275 women, H2 receptor antagonists by 255 women, and both categories of drugs by 20 women. Paper-1590666.
HP eradication may decrease the efficacy of acid secretion lowering drugs such as Proton Pump Inhibitors and H2-Receptor Antagonists. Paper-1641199.
The time dependency and extent of histamine induced down-regulation varied between the H1 and H2 receptor message. Paper-8288618.
Human gastric alcohol dehydrogenase: its inhibition by H2-receptor antagonists, and its effect on the bioavailability of ethanol. Paper-6808989.
Drug interactions of H2-receptor antagonists involving cytochrome P450 (CYPs) enzymes: from the laboratory to the clinic. Paper-2007239.
Intestinal fibroblasts exclusively expressed H1R while the muscular layers of human intestine stained positive for both H1R and H2R. Paper-11392854.
In particular, histamine, acting upon the H2 receptor for a short period of time, increased IL-10 production and reduced IL-12 secretion. Paper-8864366.
AIM: In this study, we evaluated the efficacy of H2-receptor antagonist ( famotidine) and 5-HT4 receptor agonist ( mosapride citrate). Paper-11283097.
Misoprostol, high-dose H2-receptor antagonists, proton-pump inhibitors, and COX-2 inhibitors have been shown to reduce this risk. Paper-10514982.
Fasting and secretin- stimulated serum gastrin levels were not affected by long-term treatment with histamine H2-receptor antagonists. Paper-3008061.
H1R and H2R transcript levels have been found to be up-regulated in perennial - but not in seasonal - allergic rhinitis ( AR). Paper-11233462.
H2-receptor antagonists differentially inhibit cytochrome P450 and this may affect the rate at which benzodiazepines are metabolised. Paper-7778489.
Ranitidine, another H2-receptor antagonist, has been shown to have an extremely low level of interaction with the cytochrome P450 system. Paper-5466432.
Incubation of lymphocytes with 50 U/ml IL-2 alone in 3-day culture significantly (p less than 0.005) enhanced H2 receptor expression. Paper-7265844.
H2 receptor antagonist, metiamide, did not modify the magnitude of the contractile response of the lower esophageal sphincter to gastrin I. Paper-2465561.
The prescription of sodium citrate and the H2 receptor antagonist ranitidine has superseded that of Mist. magnesium trisilicate. Paper-6794679.
The percentage of relapse-free patients, 1 year after DU or GU healing, with CBS is substantially higher than is the case with H2-receptor blockers. Paper-5515815.
Cimetidine, an H2 receptor antagonist, blocked chemoattractant production, whereas diphenhydramine, an H1 receptor antagonist, did not. Paper-5256867.
Experimental evidence suggested that H2-receptor antagonists may inhibit not only hepatic but also adrenal cytochrome P-450 dependent monooxygenases. Paper-7443862.
The inhibitory effects of histamine on CD14 expression were antagonized by H2-receptor antagonist, but not by H1 and H3/ H4 antagonist. Paper-9988439.
Pretreatment H2 receptor antagonists that differ in P450 modulation activity: comparative effects on paclitaxel clearance rates and neutropenia. Paper-258826.
However, the immunohistochemical localization of histamine receptor subtypes ( H1R, H2R, H3R, and H4R) in human nasal mucosa is unknown. Paper-10343272.
The evidence is consistent with sensitisation of both the histamine H1 and histamine H2 receptor systems by chronic beta 1-adrenoceptor blockade. Paper-689867.
Proton pump inhibitors were mostly prescribed for reflux disease (52.7%) and H2-receptor antagonists for non-specific dyspepsia (43.6%). Paper-1604933.
Proton pump inhibitors achieve healing rates by week four, which are not achieved by H2-receptor antagonists even after 12 weeks of treatment. Paper-2200160.
Immunohistochemical staining revealed expression patterns of H1R, H2R and H4R similar to those suggested by the mRNA and Western blot results. Paper-12774371.
Proton pump inhibitors (PPIs) and histamine H2 receptor antagonists (H2RAs) are two major acid-suppressing drugs used for the treatment of GERD. Paper-9715979.
The therapeutic use of CT in gastric hypersecretory states appears to be inferior and less practicable compared to the histamine-H2-receptor antagonists. Paper-3703737.
Recent investigations suggest that H1R signaling on lymphocytes may enhance whereas activation of the H2R may inhibit lymphocyte responses. Paper-8567537.
These changes persisted after H2 receptor blockade with cimetidine, but were completely abolished after H1 receptor blockade with diphenhydramine. Paper-5581148.
Pharmacological control of the human gastric histamine H2 receptor by famotidine: comparison with H1, H2 and H3 receptor agonists and antagonists. Paper-6471837.
Dimaprit, (S-[3-(N,N-dimethylamino)propyl]isothiourea). A highly specific histamine H2-receptor agonist. Part 2. Structure-activity considerations. Paper-2702151.
Thus, in human skin, VIP- mediated vasodilation includes a NO-dependent component that could not be explained by H1- and H2-receptor activation. Paper-10940516.
CONCLUSIONS: Our results suggest that histamine stimulated neutrophil adhesion is due to H1 and H2 receptor mediated activation of PLC, NOS and GC. Paper-1557113.
Proton pump inhibitors produce a greater and longer-lasting degree of suppression of acidity than conventional doses of H2-receptor antagonists. Paper-165070.
Small H1R agonists and 2-phenylhistamines interacted differentially with human and guinea pig H2R in terms of potency and efficacy, respectively. Paper-9720226.
The released histamine begins the H2-receptor mediated sequence of events in the parietal cell, which results in activation of the gastric H+/K+ - ATPase. Paper-8246813.
The efficacy of prophylactic administration of H1 and H2 receptor blockers to prevent adverse haemodynamic responses to heparin and protamine was studied. Paper-866965.
In contrast, successful treatment of GER by H2-receptor antagonists in patients resistant to the acid-suppressing effects of omeprazole is rarely reported. Paper-364425.
The modulation of the forskolin response was also observed after H2 receptor expression in HEK-293 and Sf9 cells or TSH receptor expression in COS-7 cells. Paper-1281290.
Cimetidine, an H2 receptor antagonist, reversed the histamine (10(-5) M)-mediated increase in IL-1 alpha- induced IL-1 beta synthesis. Paper-7718629.
Is antral gastrin important in the resistance of duodenal ulcers to H2 receptor antagonists or in recurrent ulceration after highly selective vagotomy? Paper-6505666.
Very important drug interactions are caused by inhibition of the hepatic microsomal enzyme cytochrome P450 by some of the H2-receptor antagonists. Paper-5442551.
The alteration of the responsiveness of LOX-1 expression to histamine was related to suppressed expression of the H2 receptor in THP-1 macrophages. Paper-9098462.
The histamine inhibition was shown to be specific for H2 receptor activation by blocking experiments with selective H1 and H2 receptor antagonists. Paper-7632849.
This paper reviews the main steps in the research of the interactions of H2-receptor antagonist drugs with cytochrome P450 ( CYP) enzymes. Paper-2007239.
Dimaprit, [S-[3-(N,N-dimethylamino)propyl]isothiourea]. A highly specific histamine H2-receptor agonist. Part 2. Structure-activity considerations. 1977. Paper-8217944.
CONCLUSIONS: These results suggest that histamine-induced stimulation of PDE4 is mediated by the H2 receptor and related to intracellular levels of cAMP. Paper-9898164.
Lack of association between atopic asthma and polymorphisms of the histamine H1 receptor, histamine H2 receptor, and histamine N-methyltransferase genes. Paper-2176308.
It is thought that the difference between these two H2-receptor antagonists may lie in their affinities for binding to the cytochrome P-450 enzymes. Paper-5466485.
The histamine H2-receptor antagonists cimetidine, ranitidine and tiotidine suppressed NK cell cytotoxicity ( NKCC) at a high concentration (10(-3) M). Paper-5736930.
Changes in serum gastrin concentration, basal acid output, or sensitivity to a given dose of histamine H2-receptor antagonist did not reflect changes in tumor size. Paper-5823283.
CONCLUSION: Proton pump inhibitor treatment provides more consistent heartburn relief than an H2-receptor antagonist, or "step-up" or "step-down" therapy. Paper-8845941.
The histamine H2-receptor antagonists have been identified as inhibitors of human liver aldehyde dehydrogenase (EC 1.2.1.3) isozymes, E1, E2, and E3. Paper-1125122.
Histamine inhibits cell proliferation and modulates the expression of Bcl-2 family proteins via the H2 receptor in human pancreatic cancer cells. Paper-12391279.
The H2 receptor agonist dimaprit (10 microM) or the H3 receptor agonist imetit (100 nM) were without significant effect on the membrane properties of SPNs. Paper-11368127.
Histamine maintained NKp46 and NKG2D expression despite the presence of inhibitory phagocytes by targeting an H2 receptor on phagocytes. Paper-10601948.
Symptomatic relief can be achieved with pro-kinetic agents, antacids, sucralfate suspension, H2-receptor antagonists and H(+)-K+ ATPase pump blockers. Paper-7212289.
Effect of a new potent H2-receptor antagonist on meal- stimulated gastric acid secretion and serum gastrin concentration in duodenal ulcer patients. Paper-4697199.
Comparison between dose-responses of prolactin, thyroid stimulating hormone and growth hormone to two different histamine H-2 receptor antagonists in normal men. Paper-3943129.
It would appear that the stimulatory effect of cimetidine on serum prolactin concentration is not mediated through its histamine H2-receptor antagonist activity. Paper-3915384.
The H2-receptor antagonists cimetidine and ranitidine were transferred from prescription only to over-the-counter ( OTC) status in Denmark on March 27, 1989. Paper-7005154.
Tolerance to H2 receptor antagonist correlates well with the decline in efficacy against gastroesophageal reflux in patients with gastroesophageal reflux disease. Paper-12189908.
The H2-receptor antagonist ranitidine completely reversed the inhibition of IL-4 and IFN-gamma production, whereas the agonist dimaprit mimicked this effect. Paper-1036237.
Ranitidine is thought to spare phase I hepatic metabolism mediated by cytochrome P-450, unlike its counterpart H2-receptor antagonist cimetidine. Paper-5884211.
Histamine and H2-receptor agonists inhibit the generation of superoxide anion from human neutrophils activated by FMLP and by substance P. Paper-6089326.
The erection-promoting action of histamine is probably due to H2 receptor activation, although another histamine receptor, possibly H3, also seems to be involved. Paper-162360.
Neither the histamine H2 receptor agonist dimaprit (1 mM) nor the histamine H3 receptor agonist S-(+)-alpha-methyl histamine (1 mM) altered short circuit current. Paper-368999.
In seven healthy volunteers, we studied how histamine H2-receptor blockade affected the reflex response to hypovolaemia induced by lower-body negative pressure ( LBNP). Paper-6505254.
BACKGROUND: Concomitant administration of an H1-receptor antagonist with an H2-receptor antagonist may enhance the wheal and flare suppression produced by the H1-antagonist. Paper-185191.
In situ hybridization with a digoxigenin-labeled H2R cRNA probe was performed on surgical specimens of nasal turbinate of patients with allergic rhinitis. Paper-1854170.
Inhibition of gastric alcohol dehydrogenase activity by histamine H2-receptor antagonists has no influence on the pharmacokinetics of ethanol after a moderate dose. Paper-8206660.
This study suggests that antral gastrin is not important in 'resistance' of duodenal ulceration either to H2 receptor antagonist treatment or to highly selective vagotomy. Paper-6505666.
The potential of famotidine, a new H2-receptor antagonist with a guanylthiazole ring structure, to interact with the cytochrome P450 system has been extensively evaluated. Paper-5466432.
Successful omeprazole therapy in patients with symptomatic gastroesophageal reflux ( GER) refractory to treatment with H2-receptor antagonists has often been reported. Paper-364425.
The present study shows that, unlike ranitidine, ebrotidine, a competitive H2-receptor antagonist, is also a non-competitive inhibitor of carbonic anhydrase I and II. Paper-1096509.
These results indicate that in H2r-transfected COS-7 cells, exposure to an agonist caused desensitization controlled by H2r phosphorylation via GRK2 and GRK3. Paper-9070038.
Intracytoplasmic domains of the human beta2 adrenergic receptor were substituted with the corresponding sequences of the human H2 receptor and stably expressed in HEK-293 cells. Paper-8658154.
Histamine H2 receptor ( H2R) stimulation controls histamine release and mediates mucus secretion, suggesting that H2R might play some role in allergic rhinitis. Paper-1854170.
Proton pump inhibitors are at least as effective, and may be more effective than histamine H2-receptor antagonists in achieving this pH goal and preventing bleeding. Paper-10760098.
This protection was antagonized by the H2 receptor antagonists cimetidine and zolantidine but not by the H1 receptor antagonists pyrilamine and diphenhydramine. Paper-11337563.
Failure of H2-receptor antagonists to affect serum calcium and immunoreactive parathyroid hormone levels in normal subjects and patients with primary hyperparathyroidism. Paper-4245468.
Studies show that patients with peptic ulcer disease treated with the H2-receptor antagonist cimetidine show significant elevations in their HDL, HDL2, and HDL3 profiles. Paper-5466513.
We describe two patients who demonstrated therapeutic responses to high dose H2-receptor antagonists after high dose omeprazole failed to suppress gastric acidity and GER. Paper-364425.
The intravenous administration of 200 mg cimetidine, an H2-receptor antagonist, was followed by a significant and marked rise in serum prolactin levels in all control subjects. Paper-4084437.
The studies using receptor subtype-selective agonists and antagonists suggested that the effect of histamine was mediated by H2 receptor but not by H1, H3 and H4 receptors. Paper-10348832.
Prolonged high-dose histamine H2-receptor dosing compromises the feedback mechanism regulating gastrin release, whilst this is maintained during dosing with omeprazole. Paper-8014500.
On the other hand, tolerance can now be explained by a gastrin- induced increase in ECL cell-derived histamine at the parietal cell H2-receptor competing with the antagonist. Paper-1548840.
Histamine H2 receptor activity (cAMP generation) has been characterized in U-937 cells before and after retinoic acid-induced differentiation into monocyte-/macrophage-like cells. Paper-5084073.
Zollinger-Ellison syndrome was treated with a histamine-H2-receptor blocker, and ectopic ACTH syndrome was controlled with trilostane, metyrapone and o,p'-DDD. Paper-8217270.
The effect of cimetidine, a new histamine H2-receptor antagonist, on meal-stimulated acid secretion, serum gastrin, and gastric emptying in patients with duodenal ulcer. Paper-2472843.
The major classes of OTC medication to be considered in this light include antacids, histamine H2 receptor antagonists, NSAIDs, cough and cold preparations and the antiasthma products. Paper-641390.
A prospective, open, multicenter clinical trial was set up to evaluate the potential interaction of ITF 282 with H2-receptor antagonists in patients affected with iron deficiency. Paper-7588162.
Using specific histamine H1 and H2 receptor antagonists, evidence is presented for the existence of both H1 and H2 receptors on human articular chondrocytes in vitro. Paper-5565081.
It is suggested that the absence of a interaction may be attributed to a lack of specificity of the H2 receptor antagonists for CYP3A, the isoenzyme responsible for CyA metabolism. Paper-496577.
In further experiments, suppression of human polyclonal IgM PFC responses by Con A and interferons, substances that activate the SIRS pathway, was inhibited by H-2 receptor antagonists. Paper-5622258.
Effect of systemically administered H1- and H2-receptor antagonists on nasal blood flow as measured with laser Doppler flowmetry in a provoked allergic reaction. Paper-653396.
The biphasic response of the ratio of H+ and gastrin (H+/G) following each meal was suppressed by both H2-receptor antagonists, with numerically lower values obtained in R than in C. Paper-4902001.
The beta-2-selective antagonist ICI118551 was a more potent inhibitor of acid production than both the beta-1 antagonist practolol and the H2-receptor antagonist cimetidine. Paper-5806476.
Activation of the CCK2 receptor results in mobilization of histamine (and pancreastatin) from the ECL cells with consequent activation of the parietal cell histamine H2 receptor. Paper-1880369.
Modulation of the permeability of H2 receptor antagonists cimetidine and ranitidine by P-glycoprotein in rat intestine and the human colonic cell line Caco-2. Paper-1708119.
Its various actions are mediated not only by the two well known H1- and H2-receptor subclasses but also by the recently discovered H3-receptors, with distinct localization and pharmacology. Paper-5403792.
After 24-h histamine treatment, known to desensitize H1 receptors, reapplication of histamine increased cell coupling in a way prevented by ranitidine, an H2 receptor blocker. Paper-10613257.
In another group of six healthy subjects the postprandial plasma PP release was not affected by inhibition of the gastric H+ secretion by the H2-receptor antagonist ranitidine. Paper-4201392.
Previously, omega-guanidino- and omega-aminoalkanamides, structurally derived from arpromidine-like histamine H2 receptor agonists, were reported as novel neuropeptide Y Y1 antagonists. Paper-1683745.
Mast cell chemotaxis toward histamine could be blocked by the dual H3/ H4 receptor antagonist thioperamide, but not by H1 or H2 receptor antagonists. Paper-9720234.
However, other known or unknown intracellular signals, could also be triggered by the stimulation in a transfected cell of a single H1 or H2 receptor through coupling to different G-proteins. Paper-8077794.
Our hypergastrinaemic group had plasma gastrin concentrations similar to, or greater than those reported during treatment with drugs such as omeprazole and histamine H2 receptor blockers. Paper-6613963.
The effects on airflow resistance of an inhaled H1 receptor antagonist, clemastine, and an H2 receptor antagonist, cimetidine, have been investigated in normal and asthmatic subjects. Paper-3673618.
The histamine H2 receptor ( H2r) belongs to the heptahelical receptor family; upon agonist binding, members of this family activate a G protein and the downstream effector adenylyl cyclase. Paper-9070038.
A cyclooxygenase inhibitor or a thromboxane A2-prostaglandin H2 receptor antagonist partially but significantly reduced the effect of the factor.(ABSTRACT TRUNCATED AT 250 WORDS) Paper-404830.
Histamine-induced increase of cAMP was inhibited by the H2 receptor antagonist famotidine, whereas induction of IP3 was not observed, making signaling via the H1 receptor unlikely. Paper-10211314.
H2r desensitization was not affected by protein kinases A and C (PKA and PKC) inhibitors but was remarkably reduced by Zn(2+), an inhibitor of G protein-coupled receptor kinases (GRKs). Paper-9070038.
The chemoattractant activity of histamine itself is not influenced by H1 or H2 receptor antagonists, thus it is possible that an eosinophil has a third type of histamine receptor. Paper-2882143.
However, H2 receptor antagonist ranitidine and H3/ H4 receptor antagonist thioperamide did not affect the histamine mediated hyper-phosphorylation of STAT6. Paper-12451572.
This interference clearly implies that tiotidine biases the system to Galphas-coupled form of the H2 receptor and turns Galphas-protein less available to interact with beta2-adrenoreceptor. Paper-9779376.
The effect of an i.v. bolus of the H2-receptor antagonist ranitidine 50, 100, 200 and 300 mg on serum levels of prolactin, TSH, GH, LH, FSH and cortisol was studied in 12 normal males. Paper-4199121.
Thus H2 receptor antagonists probably caused abnormalities in T helper cells leading to lymphokine unresponsiveness and subsequently loss of cellular immunity to candidal antigen. Paper-6610435.
The ratio of relative gene copy numbers between the SAR and NR groups were as follows: H1R, 0.85 (P = 0.52); H2R, 0.67 (P = 0.35); EGF, 1.02 (P = 0.93), and EGFR, 103.5 (P < 0.05). Paper-9899807.
These effects of histamine were antagonized by cimetidine, an H2 receptor antagonist, but not by selective H1 and H3 receptor blockers, and were mimicked by an H2 receptor agonist. Paper-1538479.
The effect of an H2-receptor antagonist on food-stimjlated acid secretion, serum gastrin