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Keratin 16 and keratin 17 mutations cause pachyonychia congenita. Paper-253549.
In hyperplastic urothelium all cells synthesised CK17, but not CK20. Paper-1416123.
After induction of apoptosis three fragments of both K15 and K17 could be observed by 2 -DE. Paper-10965556.
A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita. Paper-12596046.
Apoptosis-induced cleavage of keratin 15 and keratin 17 in a human breast epithelial cell line. Paper-10965556.
The trichilemmal carcinoma demonstrated abundant cytoplasmic staining for cytokeratin 17 and c-erb-B2. Paper-9796366.
Basal and intermediate cells were CK20 negative and cytokeratin 17 ( CK17) positive. Paper-1416123.
By using mass spectrometry we could determine the caspase cleavage sites, one in K15 and two in K17. Paper-10965556.
The sequence VEMD/A at the cleavage site located in the conserved linker region was found in K15 and K17. Paper-10965556.
During culture, skin-derived antileukoproteinase and keratin 17 were expressed only in the epithelial tongue. Paper-12884037.
During differentiation, synthesis of CK17 ceased in superficial cells while the synthesis of CK20 started. Paper-1416123.
We found that expression of cytokeratin 17 and/or cytokeratin 5/6 in tumor cells was associated with a poor clinical outcome. Paper-9265910.
Homotypic keratin interactions has been previously shown for keratin 17 ( K17) and keratin 18 ( K18) by Schnabel et al. Paper-15315490.
Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita. Paper-9129333.
Expression of keratins ( K10 and K17) in steatocystoma multiplex, eruptive vellus hair cysts, and epidermoid and trichilemmal cysts. Paper-1108778.
Immunohistochemistry was performed for p63, cytokeratin 34BE12, cytokeratin 17 ( CK17), and low-molecular cytokeratin CAM5. Paper-14377801.
It is shown here that normal cells produce keratins K5, K6, K7, K14, and K17, whereas tumor cells produce mainly keratins K8, K18, and K19. Paper-6576794.
At the molecular level it has been shown that mutations in keratin K6a or K16 cause PC-1 whereas those in K6b or K17 lead to PC-2. Paper-12596046.
Recessive epidermolysis bullosa simplex phenotype reproduced in vitro: ablation of keratin 14 is partially compensated by keratin 17. Paper-10149157.
CONCLUSIONS; Positive staining for CK5/6 or CK17 was associated with a worse prognosis, high tumor grade and positive axillary lymph nodes. Paper-13716788.
RESULTS: EPPK was colocalized with keratin 17 ( K17) more extensively than with other keratins examined in wounded epidermis. Paper-15455499.
Tissue obtained during the extirpation of the tumor was subjected to immunohistochemical staining for cytokeratin 15, cytokeratin 17, and c-erb-B2. Paper-9796366.
Heterozygous mis-sense or small in-frame insertion/deletion mutations were detected in the genes encoding keratins K6a, K16, and K17 in all cases. Paper-9129333.
In this group the pad test improved from a preoperative mean of 39.1 g (8-112) to 9.7 g (2-29) and LPP from a mean of 37.1 cm H2O (25-50) to 42.0 cm H2O (30-58). Paper-1514805.
The expression profiles of K17, involucrin, dermal Ki-67, fibronectin and chondroitin sulfate were higher in the fetal skin than in adult skin. Paper-14143817.
Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2. Paper-11292959.
In a previous study of 78 breast carcinoma specimens, we noted an association between poor clinical outcome and the expression of cytokeratin 17 and/or cytokeratin 5 mRNAs. Paper-9265910.
OBJECTIVE: To identify mutations in 22 families presenting with clinical symptoms of either PC-1/focal non-epidermolytic palmoplantar keratoderma ( FNEPPK) or PC-2. Paper-12596046.
Keratin 15 ( K15) and keratin 17 ( K17) are intermediate filament (IF) type I proteins that are responsible for the mechanical integrity of epithelial cells. Paper-10965556.
In total, CK5/6 and CK17 were both determined positive in 33.9% (38/112) of the 112 tumor samples, and 46.4% (52/112) were regarded as positive for CK5/6 or CK17. Paper-13716788.
Significantly increased numbers of dividing keratinocytes were present in 48h and 96h reactions, concurrent with high levels of expression of K16 and more moderate expression of K17. Paper-1562731.
Selected cases were then stained for immunohistochemical markers ( CD34, CK17, and NGFR/ p75) that have been used as evidence for tricholemmal differentiation in some studies. Paper-12937826.
We compared the patterns of keratin 10 ( K10) and keratin 17 ( K17) expression in epidermoid cysts, trichilemmal cysts, eruptive vellus hair cysts, and steatocystoma multiplex. Paper-1108778.
RESULTS: Here, we report four new missense and five known mutations in K6a; one new deletion and three previously identified missense mutations in K16; plus one known mutation in K17. Paper-12596046.
Using QRT-PCR data we identified a four-gene model ( PSMD10, HSD17B12, FLOT2 and KRT17) that predicts M/NM status with 77% success in a separate 79-sample validation group of HNSCC samples. Paper-13065823.
Keratin 17 is expressed during the course of SLS-induced irritant contact dermatitis, but unlike keratin 16, the degree of expression is unrelated to the density of dividing keratinocytes. Paper-1562731.
Epidermoid cysts expressed K10 and eruptive vellus hair cysts expressed K17, whereas trichilemmal cysts and steatocystoma multiplex showed expression of both K10 and K17. Paper-1108778.
The results demonstrate that both K16 and K17 expression are features of acute irritant contact dermatitis reactions, but suggest that the factors which influence and control their expression differ. Paper-1562731.
Only one of these loci contains the functional CK 17 gene which is located only approximately 5 kbp 5'-upstream of the CK 16 gene, whereas the other two contain unprocessed CK 17 pseudogenes. Paper-7352177.
When we considered 91 patients whose pathological type was invasive ductal carcinoma, we found that there was also an association between CK5/6 or CK17 immunostaining and high grade ( P = 0.030). Paper-13716788.
METHODS: We examined the immunohistochemical staining of p16, CK8, and CK17 in 134 cervical tissues obtained by punch biopsy and graded as follows: CIN I (n=39), CIN II (n=31), CIN III (n=43), SCC (n=21). Paper-14348336.
The expression of K5, K10, K6, and K17 was the same in EPPK(-/-) mice after wounding as in normal mice, but diameters of keratin filaments were reduced in EPPK(-/-) keratinocytes. Paper-15455499.
METHODS AND STUDY DESIGN: We carried out an immunohistochemical assay for CK5/6 and CK17 markers on formalin-fixed invasive carcinoma samples from 112 patients who were diagnosed between 2000 and 2002. Paper-13716788.
K15 and K17 proteolysis was observed during staurosporine-induced apoptosis and anoikis (anchorage-dependent apoptosis) as well and was shown to be caspase-dependent. Paper-10965556.
The use of complex phytoadaptogen in the treatment of patients with leukoplakia normalized expression of Fas-APO-1 antigen and keratin 17; increased expression of CD54 attested to activation of immune effectors. Paper-10931502.
Initially, reserve recruits were significantly older and heavier and had greater fat-free mass ( FFM; 64.6 vs. 59.3 kg) and lower maximal oxygen uptake (Vo(2)max; 39.1 vs. 43.9 ml.kg(-1).min(-1)) than regular recruits. Paper-11256519.
ChIP assays demonstrate that BRCA1 is recruited to the promoters of KRT5, KRT17 and CDH3, and re-ChIP assays confirm that BRCA1 is recruited independently to form c-Myc and Sp1 complexes on the CDH3 promoter. Paper-14576610.
Among the members of the cytokeratin ( CK) subfamily of intermediate filament (IF) proteins, CK 17 is remarkable as it is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Paper-7352177.
Coordinate expression of cytokeratin 8 and cytokeratin 17 immunohistochemical staining in cervical intraepithelial neoplasia and cervical squamous cell carcinoma: an immunohistochemical analysis and review of the literature. Paper-14348336.
These five genes were secretory leukocyte protease inhibitor ( Slpi), keratin 17 ( Krt17), annexin A1 ( Anxa1), myosin light peptide 6 ( Myl6) and endoplasmic reticulum protein 29 ( Erp29). Paper-15373422.
Keratin 6, keratin 16, and keratin 17, which are known to be upregulated during keratinocyte activation and in hyperproliferative epidermis, were highly expressed in cultured skin substitutes in vitro. Paper-10826784.
We compared the ratio of RNase L isoforms in PBMCs from 11 patients with CFS (6 women and 5 men; mean age +/- standard deviation, 43.2 +/- 13.8 years) and PBMCs from 14 healthy well-matched volunteers (10 women and 4 men; age, 39.1 +/- 11.6 years). Paper-9916101.
These results indicate that during urothelial regeneration after NaSac treatment, specific superficial cell types develop in which the switch to uroplakin synthesis and transition from CK17 to CK20 synthesis are crucial events for terminal differentiation. Paper-1416123.
We report here the results of crystallization of this protein and crystallographic parameters of the monellin crystals; space group is P21; the cell parameters are 39.1 X 71.5 X 86.9 A with beta = 107.6 degrees; and there are 4 monellin molecules/asymmetric unit. Paper-3768959.
After standardisation on age, estimates for the national prevalence of multiple sclerosis in French farmers were 65.0 per 100,000 inhabitants (95% confidence interval 62.5 to 67.5), 41.9 per 100,000 in men ( 39.1 to 44.7) and 96.3 per 100,000 in women (92.0 to 100.6). Paper-13294996.
CONCLUSIONS: Results of the present study showed that p16, CK8, and CK17 immunostaining differed according to the degree of cervical intraepithelial lesions and SCC, and surprisingly, that staining was significantly correlated with increasing lesion grade of CIN and SCC. Paper-14348336.
AIMS AND BACKGROUND: To evaluate the immunohistochemical characterization of CK5/6 and CK17 and whether the expression level of the two markers was correlated with clinical outcome or pathological feature in triple negative (ER-, PR-, HER-2-) patients with breast cancer. Paper-13716788.
These histological subtypes can be differentiated by immunohistochemistry: while positivity for mucin-2 ( MUC2) and caudal homeobox gene transcription factor-2 (CDX2) excludes the pancreatobiliary subtype, positivity for MUC1 and cytokeratin-17 ( CK17) excludes the intestinal subtype. Paper-15241779.
The expression of MUC1 and CK17 was restricted to pancreatic ductal carcinoma (41 of 46, 89%; 38 of 46, 83%, respectively), the ampullary carcinoma of pancreatobiliary origin (6 of 6, 100%; 5 of 6, 83%, respectively), and intrahepatic cholangiocarcinoma (20 of 24, 83%; 17 of 24, 71%, respectively). Paper-11292959.
By using a dye laser with a tuning range of 4.2 nm to a yield resolution of 39.1 mum, we have observed interferograms and their Fourier transforms and autocorrelations to study effects of defocusing and the size ratio of speckle to the CCD pixel for a plane diffuse object positioned normal to the incident beam. Paper-12775322.
An immunohistochemical panel consisting of desmin, smooth-muscle actin, S-100, vimentin, CD34, carcinoembryonic antigen, pancytokeratin, cytokeratin 7, cytokeratin 8, cytokeratin 17, cytokeratin 18, cytokeratin 19, and cytokeratin 20 was applied to paraffin sections. Paper-11480861.
Mature squamous metaplastic epithelium showed a keratin distribution pattern comparable to ectocervical squamous epithelium, with the exception of keratin 17, which was only sporadically found in the basal layer of ectocervical epithelium and was always present in the basal cells of mature squamous metaplastic epithelium. Paper-7210487.
We studied the expression of cytokeratin 7 ( CK7), cytokeratin 17 ( CK17), cytokeratin 20 ( CK20), CDX2, mucin 1 ( MUC1), mucin 2 ( MUC2), and mucin 5AC (MUC5AC) in 46 cases of pancreatic ductal carcinoma, 18 ampulla of Vater adenocarcinomas, and 24 intrahepatic cholangiocarcinomas. Paper-11292959.
The Kaplan-Meier curve showed that positive staining for CK5/6, CK17, or CK which means CK5/6 positive or CK17 positive, was associated with worse disease-free survival ( P = 0.020, P = 0.032, P = 0.003), and positive staining for CK5/6 or CK was associated with worse overall survival ( P = 0.027, P = 0.015). Paper-13716788.
These synonyms are used for gene KRT17 (keratin 17): PCHC1, PC2, PC, Keratin-17, Keratin, type I cytoskeletal 17, K17, Cytokeratin-17, CK-17, 39.1.
These accession numbers are used for gene KRT17: CR605895 (NCBI_GENBANK__AC), CR595280 (NCBI_GENBANK__AC), A6NDV6 (UNIPROT__AC), A5Z1M9 (UNIPROT__AC).
KRT17 is a homologue of zgc:92533 (zgc:92533) from Danio rerio.
KRT17 is a homologue of zgc:92061 (zgc:92061) from Danio rerio.
KRT17 is a homologue of zgc:109868 (zgc:109868) from Danio rerio.
KRT17 is a homologue of si:dkeyp-113d7.7 (si:dkeyp-113d7.7) from Danio rerio.
KRT17 is a homologue of si:dkeyp-113d7.4 (si:dkeyp-113d7.4) from Danio rerio.
KRT17 is a homologue of LOC100331182 (keratin 15-like) from Danio rerio.
KRT17 is a homologue of KRT17 (keratin 17) from Pan troglodytes.
KRT17 is a homologue of KRT17 (keratin 17) from Canis lupus familiaris.
KRT17 is a homologue of KRT17 (keratin 17) from Bos taurus.
KRT17 is a homologue of Krt17 (keratin 17) from Mus musculus.
KRT17 is a homologue of Krt17 (keratin 17) from Rattus norvegicus.
KRT17 is a homologue of krt15 (keratin 15) from Danio rerio.
KRT17 is a homologue of krt1-19d (keratin, type 1, gene 19d) from Danio rerio.
KRT17 is a homologue of cyt1l (type I cytokeratin, enveloping layer, like) from Danio rerio.
KRT17 is a homologue of cyt1 (type I cytokeratin, enveloping layer) from Danio rerio.
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