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Medullary interstitium strongly expressed MCP but not DAF. Paper-8227321.
Bile duct cells were reactive for MCP and protectin. Paper-8224305.
No appreciable difference was seen in CD46 or CD59 expression. Paper-11499129.
CD46 and CD35 were not detected in control tissue sections. Paper-12243064.
CD46, CD55, and CD59 are complement regulatory proteins. Paper-14150106.
CD59, DAF and MCP were all shown to be expressed by MCF7. Paper-1724105.
As a result, pigs transgenic for both hMCP and hDAF have been produced. Paper-9206599.
The efficiency of binding C3b to CR1 or MCP was maximal at pH 6. Paper-6530316.
CD46 was upregulated in 77%, CD55 in 55% and CD59 in 59% of tumors. Paper-12939305.
Relative roles of hCD46 and hCD55 in the regulation of hyperacute rejection. Paper-8479023.
Villous cytotrophoblast cells expressed MCP but were largely devoid of DAF. Paper-7274721.
RESULTS: Protectin and MCP were widely expressed in normal and diseased mucosae. Paper-1443556.
We demonstrate that apoptotic neuronal lines lose the C regulators CD46 and CD59. Paper-11389249.
A study of human DAF, CD59, MCP transgene in xenotransplantation. Paper-8929626.
Juxtaglomerular apparatus was abundant in DAF and MCP but not in HRF20. Paper-8227321.
Physical association of moesin and CD46 as a receptor complex for measles virus. Paper-177016.
Chromatin immunoprecipitation confirms binding of STAT3 to the CD46 promoter. Paper-13387598.
Expression of endogenous pig CD46 was detected with polyclonal sera against human CD46. Paper-8401736.
Expression of MCP and DAF on MCF-7 cell lines was analyzed by flow cytometry. Paper-8230763.
Expression of CD46, CD55, and CD59 was determined by two-color flow cytometry. Paper-14150106.
This effect could be abrogated by the addition of monoclonal antibody against DAF or MCP. Paper-11728857.
This effect could be abrogated by the addition of monoclonal antibody against DAF or MCP. Paper-368157.
Fetal neurons were stained for CD59 and CD46 and were negative for CD55 and CD35. Paper-8384404.
Forty RA patients with involvement of some or all of MCP or PIP joints were recruited. Paper-8074202.
Mice transgenic for human CD46 and CD55 are protected from human complement attack. Paper-173790.
Human CD59 and MCP can only protect NIH/3T3 cells from human complement-mediated lysis. Paper-8872872.
Presenilin/gamma-secretase cleaves CD46 in response to Neisseria infection. Paper-14200458.
Our results reveal ADAM10 as an important regulator of CD46 expression during apoptosis. Paper-12071259.
Expression of human DAF and MCP on pig endothelial cells protects from human complement. Paper-173789.
In 5 patients mutations were identified: 1 in CFH, 1 in CFI, 1 in CD46, and 2 in C3. Paper-14088795.
CD46- and CD150-independent endothelial cell infection with wild-type measles viruses. Paper-9679242.
0. Low ionic conditions enhanced the C3b binding and cofactor activity of both CR1 and MCP. Paper-6530316.
Nevertheless, it acts additively, and in certain tumors even synergistically, with CD55 and CD46. Paper-9827543.
Using a yeast two-hybrid screen, we identified a physical interaction between CD46 and DLG4. Paper-9155564.
Results: CD46, CD55 and CD59 were highly expressed in HNSCC cells including T1/T2N0M0 stages. Paper-12223207.
In CML patients, the high level of MCP and the lack of CR1 were normalized after medical treatment. Paper-7496157.
We observed that expression of CD46 and CD59 were higher in patients with CR than in group with NR. Paper-14150106.
Significant coexpression of CD55 & CD46 on the IAM suggests some functional cooperation at this site. Paper-12060338.
We demonstrate that the prostatic epithelium, in addition to MCP, expresses CD59 but not DAF. Paper-8222955.
2. The isoelectric point (pI) of MCP was acidic (approximately 4.0), while that of CR1 was 6. Paper-6530316.
Human herpesvirus 7 infection increases the expression levels of CD46 and CD59 in target cells. Paper-13173665.
Similar vaccines targeting CD46 and CD59 would eliminate any cell overexpressing a complement inhibitor. Paper-9147210.
In summary, the expression of E1A gene products inhibited IFN- MCP independently of virus infection. Paper-7586532.
Porcine MCP gene promoter directs high level expression of human DAF ( CD55) in transgenic mice. Paper-8409917.
Production of transgenic pigs expressing human DAF ( CD55) regulated by the porcine MCP gene promoter. Paper-10588212.
A functional interaction between CD46 and DLG4: a role for DLG4 in epithelial polarization. Paper-9155564.
F(ab')2 fragment of anti- DAF was much more effective in causing enhancement of lysis than that of anti- MCP. Paper-1389598.
HRF20 was most strongly expressed in the peritubular capillaries where MCP was not detectable. Paper-8227321.
Thus, cultured normal human melanocytes express functionally active MCP and DAF but not CD59. Paper-1389598.
MCP expression was up-regulated by IL-1 beta, but not by TNF alpha or INF gamma. Paper-555613.
RESULTS: MCP, DAF, and CD59 were found to be expressed in human endometrium and fallopian tube. Paper-418381.
We show that an interaction between CD46 and DLG4 is important for polarization in epithelial cells. Paper-9155564.
Group C, adenovirus serotype 5 (Ad5) infection inhibits both IFN- MCP and cellular protein synthesis. Paper-7586532.
The optimal pH for the first and second cleavage of either substrate was 6.0 for MCP and 7.5 for CR1. Paper-6530316.
Human CD46 rather than CD55 is a key element in protection against complement activation in vitro. Paper-8414948.
MCP and HRF20 were clearly seen in the glomerular capillaries, while DAF was only faintly observed. Paper-8227321.
Germline mutations were identified in 17% of the index cases; 12% in CFH, 3% in CD46 and 2% in CFI. Paper-14201935.
Effect of transfectant molecules, MCP, DAF, and MCP/ DAF hybrid on xenogeneic vascular endothelium. Paper-8223942.
There was no association between the pattern or intensity of CD46 and CD59 expression and tumour differentiation. Paper-1612917.
Dissecting sites important for complement regulatory activity in membrane cofactor protein ( MCP; CD46). Paper-8578703.
Inhibition of CD46 and CD59 resulted in increased susceptibility of syncytiotrophoblasts to complement lysis. Paper-7551293.
These include decay-accelerating factor ( DAF, CD55), membrane cofactor protein ( MCP, CD46) and CD59. Paper-8955884.
In contrast, fetal astrocytes were strongly stained for CD59, CD46, CD55, and were negative for CD35. Paper-8384404.
Contribution of DAF in protecting melanocytes against complement attack was much more than that of MCP. Paper-1389598.
Expression of complement restriction factors ( CD46, CD55 & CD59) in head and neck squamous cell carcinomas. Paper-12223207.
Protection of xenogeneic cells from human complement-mediated lysis by the expression of human DAF, CD59 and MCP. Paper-8872872.
Recently, however, murine homologues of DAF and MCP have been identified, prompting a search for the rat counterparts. Paper-8298026.
PIP joints, MCP joints and wrists of 80 patients with rheumatoid arthritis were operated on with late synovectomy. Paper-2512096.
These findings indicate that murine moesin is neither a receptor nor a CD46 coreceptor for MV entry into mouse ES cells. Paper-1307074.
Human cells express C-regulatory proteins, CD46 and CD55, thereby circumventing attack by C3, a major effector of C. Paper-1230833.
Endothelial cells of portal vessels and centrilobular veins expressed high levels of DAF, MCP, and protectin. Paper-8224305.
RESULTS: Five hundred forty-four manic patients were psychotic, 364 (33.4%) being MCP, 180 (16.5%) MIP. Paper-12345333.
Acute humor xenograft rejection occurred at a median time of 152 hr in hDAF hearts and 162 hr in hDAF/ hMCP organs. Paper-10646983.
In the temporal cortex, MCP and CD59 mRNA were expressed by glia and at low level by neurons, but DAF was not detected. Paper-8304552.
In cancer cells, the expression of CD59/ HRF20 and MCP was diminished, whereas DAF expression was markedly enhanced. Paper-167209.
Membrane cofactor protein ( MCP; CD46) regulates the complement cascade by inhibiting C3b and C4b deposited on self tissue. Paper-9262092.
The specificity of the two MB for the corresponding CRP was assessed by ELISA using purified CD46, CD55 and CD59. Paper-10774366.
Cells in suspension and cells growing in TMSs showed a similar expression of membrane co-factor protein ( MCP, CD46) and CD59. Paper-1011089.
Simultaneous evaluations of 86 shoulder, elbow, knee, ankle, 84 wrist, 420 MCP and PIP, and 430 MTP joints were recorded. Paper-5624546.
Distribution of complement regulators ( CD46, CD55 and CD59) in skin appendages, and in benign and malignant skin neoplasms. Paper-7301062.
8. Therefore, compared to CR1, MCP possesses distinct functional profiles relative to C3b-binding and factor I-cofactor activity. Paper-6530316.
DAF and MCP were observed at the surface of syncytiotrophoblasts (ST) and extravillous trophoblast (EVT) in all subjects. Paper-7578025.
CD46 and CD150 (signalling lymphocytic activation molecule, SLAM) have been described as cellular receptors for certain MV strains. Paper-9679242.
In conclusion level of expression of CD46, CD55, and CD59 could be clinically helpful to predict the response to rituximab therapy. Paper-14150106.
Human CD46 but not CD59 in transgenic mice protects against hyperacute rejection evoked by ex vivo perfusion with human serum. Paper-958308.
Heterotopic heart xenotransplantation was performed in baboons with either hDAF (n=5) or hDAF/ hMCP (n=5) transgenic pig organs. Paper-10646983.
Levels of complement regulatory proteins, CD35 ( CR1), CD46 ( MCP) and CD55 ( DAF) in human haematological malignancies. Paper-7496157.
However, unlike for CD46, CD55 displayed patchy staining over the acrosome, with some variation between individual spermatozoa. Paper-12060338.
Conversely, in meningitis, the ependyma, subependyma and choroid plexus epithelia were strongly stained for CD46 and CD35. Paper-12243064.
In contrast to this reciprocal expression of CD55 and CD46, CD59 was broadly distributed on the cell membrane in all layers. Paper-10439547.
CONCLUSIONS: MCP and MIP manias occurred in nearly half of this largest sample of manic patients ever reported. Paper-12345333.
In lesional skin, however, the expression of MCP and DAF in endothelium was either undetectable or only present to a very slight degree. Paper-8226775.
In contrast, tissue samples from colorectal adenocarcinomas showed clear staining for both CD59 (10/18) and, more markedly, CD46 (15/18). Paper-1612917.
None of the C+ fibers immunostained for IgG or IgM, and none failed to immunostain for CD59 or CD46-inhibitors of the complement cascade. Paper-1295607.
C3b/C4b receptor ( CR1) and membrane cofactor protein ( MCP) are integral membrane glycoproteins with factor I-dependent cofactor activity. Paper-6530316.
Genetic mapping studies within the E1A gene demonstrated that expression of only the first exon of E1A was sufficient to inhibit IFN- MCP. Paper-7586532.
These include complement receptor 1 ( CR1), decay-accelerating factor ( DAF, CD55) and membrane cofactor protein ( MCP, CD46). Paper-8298026.
The expression of hMCP on tissues where hDAF is not expressed could provide these tissues with protection against human complement mediated lysis. Paper-9206599.
The double combination of CRPs, hDAF- hMCP, and hMCP- hCD59 survived over 50% in the presence of 50% human serum, compared to the control. Paper-12049282.
Characterization of complement-mediated liver damage and protection in control and transgenic mice for human complement blockers MCP and DAF. Paper-556502.
Membrane complement inhibitors ( CD46, CD55 and CD59) are upregulated in some human cancers indicating that they play a role in immune evasion. Paper-12939305.
In contrast to E1A-negative, parental cell lines, IFN- MCP was blocked in Ad5 E1A-transfected epithelial and fibroblastic cell lines. Paper-7586532.
Analysis of membrane complement regulatory proteins (mCRP) on breast carcinoma cells revealed a heterogenous expression of CD46, CD55 and CD59. Paper-1970777.
To date, 29 different mutations of CD46 have been reported, with incomplete penetrance and better clinical outcome compared with CFH mutations. Paper-12934137.
Expression of complement regulatory proteins: CD46, CD55, and CD59 and response to rituximab in patients with CD20+ non-Hodgkin's lymphoma. Paper-14150106.
CD46 promoter activity is induced by activation of STAT3 and blocked by a dominant-negative form of STAT3 in luciferase reporter assays. Paper-13387598.
Adenovirus-mediated gene transfer of the triple human complement regulating proteins ( DAF, CD59, MCP) in xenogeneic pig liver perfusion. Paper-8414891.
E1A's inhibition of IFN- MCP has the net effect of promoting the selective NK cell-mediated clearance of Ad-infected or Ad-transformed human cells. Paper-7586532.
Of the other complement regulatory proteins expressed by PMN, only CD59 colocalized with CR1, while CD55 and CD46 were almost absent. Paper-2024331.
Moreover, the cell viability was increased more than 65% and 80% in the combination of human DAF- CD59 and DAF- MCP- CD59, respectively. Paper-12049282.
Both CD46 and CD59 were shed from cells, CD46 as a soluble form following MMP cleavage, and CD59 on apoptotic blebs and as a soluble form. Paper-11389249.
Co-purification of soluble membrane cofactor protein ( CD46) and human herpesvirus 6 variant A genome in serum from multiple sclerosis patients. Paper-10777310.
Mutation analyses were performed in the genes CFH, CD46 and CFI and in the six potential susceptibility genes, FHR1 to FHR5 and C4BP. Paper-14201935.
CD46 and CD59 were either lacking or only weakly expressed in the epithelial component of control colorectal mucosa: 2/15 and 5/15, respectively. Paper-1612917.
Thus, MCP appears to be developmentally regulated in the human liver and is expressed in the absence of DAF on the early hepatic epithelium. Paper-7626443.
Although MCP expression on haemopoietic cells was also limited, by contrast with DAF the developing hepatic epithelium was strongly MCP-positive. Paper-7626443.
Immunohistochemically by electron microscopy, CD46 and moesin were found to be localized at sites of the cellular membrane where MV particles adsorbed. Paper-177016.
Basolateral membranes of the proximal tubules and collecting ducts expressed MCP strongly, while there was no expression of DAF in the proximal tubules. Paper-8227321.
In addition, immunohistochemical results indicated a high level of expression of hMCP on neural tissues and islets where hDAF was absent or weakly expressed. Paper-9206599.
Several lines of evidence point to the role of c- Yes, a member of the Src family of nonreceptor tyrosine kinases, in CD46 phosphorylation. Paper-9158171.
The CD46 promoter contains two binding sites for activated STAT3 and mutations introduced into the major site abolished STAT3 binding. Paper-13387598.
At the usual expression rate, DAF and MCP protected SEC from human complement mediated cell lysis, but CD59 did not block human complement attack on SEC. Paper-576004.
Background: Tumor cells can escape complement-dependent cytotoxicity ( CDC) by expressing complement restriction factors (CRFs), CD46, CD55 and CD59. Paper-12223207.
IFN- MCP was not inhibited by infection with dl343, despite the production of large amounts of both early (E1B, p55) and late (hexon) Ad proteins. Paper-7586532.
The aim of this study was to investigate a possible correlation between elevated levels of soluble CD46 and the presence of serum HHV-6 DNA in MS patients. Paper-10777310.
Changes in the nephrologist MCP this year and the MMA changes to provider reimbursement coming in 2005 are reprioritizing the parameters for reimbursement. Paper-10865098.
Concordance was noted in 67% of the evaluations and this was significant for the MCP, PIP, elbow, shoulder, knee, MTP, ankle, but not wrist joints. Paper-5624546.
The results indicate that CD46 is expressed preferentially on the apical membranes while moesin appears to be present at similar levels on both surfaces. Paper-265248.
Complement regulatory molecules, membrane cofactor protein ( MCP), decay accelerating factor ( DAF) and CD59, protect body cells from autologous complement. Paper-1389598.
The identification of CD46 as a virus receptor and of the involvement of moesin sheds some light on the molecular events occurring during virus entry into the cell. Paper-437609.
The co-purification of sCD46 and HHV-6 DNA from MS sera indicates that HHV-6 is tightly connected to its receptor, CD46, in the serum of MS patients. Paper-10777310.
However, we did not find that porcine endothelial cells expressing both hDAF and hMCP were better protected than those expressing hDAF alone. Paper-9206599.
The complement regulatory proteins CD46 and CD59, but not CD55, are highly expressed by glandular epithelium of human breast and colorectal tumour tissues. Paper-1612917.
CD46 (membrane cofactor protein, MCP) is a cell surface complement regulatory protein which may have an additional role in human sperm-egg interaction. Paper-850221.
Identification of the complement regulatory proteins CD46, CD55, and CD59 in human fallopian tube, endometrium, and cervical mucosa and secretion. Paper-418381.
The demonstration herein that neurons express only very low levels of CD59 and MCP and lack both CR1 and DAF might explain their susceptibility to C damage. Paper-8304552.
Purification and functional properties of soluble forms of membrane cofactor protein ( CD46) of complement: identification of forms increased in cancer patients' sera. Paper-378825.
In this review, we describe different CD46 and CD150 transgenic models and detail their utilization in the study of various aspects of measles pathogenesis. Paper-13608420.
Reverse transcriptase-polymerase chain reaction revealed CD59, MCP, and to a lesser degree, DAF mRNA both in the choroid plexus and temporal cortex. Paper-8304552.
Nevertheless, certain malignant cells, particularly those undergoing apoptotic stress, can activate homologous C, overcoming the regulatory actions of CD46 and/or CD55. Paper-1230833.
Molecular assembly of CD46 with CD9, alpha3-beta1 integrin and protein tyrosine phosphatase SHP-1 in human macrophages through differentiation by GM-CSF. Paper-9195287.
We found that antibodies to moesin or CD46 separately inhibited MV-cell interactions to a high percentage in the plaque test, by approximately 85 and 75%, respectively. Paper-177016.
We detected the presence of decay-accelerating factor ( DAF) and CD59 and have confirmed the presence of Membrane Cofactor Protein ( MCP) and SP-40,40 on human sperm. Paper-7584635.
Our results suggest that under stress, the high expression of CRPs ( CD46, CD55, and CD59) could protect endometrial injured cells against complement mediated lysis. Paper-9819725.
Homologous complement activation is restricted on cells by the complement regulators, decay-accelerating factor ( DAF), membrane cofactor protein ( MCP) and CD59. Paper-8418722.
In humans, they include decay-accelerating factor ( DAF, CD55), membrane cofactor protein ( MCP, CD46), complement receptor 1 ( CR1, CD35) and CD59. Paper-11776132.
Normal human sera contained 10-60 ng/ml of soluble membrane cofactor protein ( MCP, CD46) whereas sera of > 50% of the cancer patients contained > 60 ng/ml. Paper-378825.
We conclude that GC infection leads to rapid tyrosine phosphorylation of the CD46 Cyt2 tail and that the Src kinase c- Yes is involved in this reaction. Paper-9158171.
An immunoaffinity column comprised of immobilized monoclonal antibodies to CD46 was developed to isolate sCD46 from cell free body fluids of MS patients and controls. Paper-10777310.
In mouse and rat a single membrane inhibitor, Crry, appeared to perform the functions of both DAF and MCP and was proposed to be the functional analogue of both. Paper-8298026.
Overall, this study suggests that C regulatory proteins, and in particular CD59 and MCP, are required from the very early stages of gestation within the fetus itself. Paper-7626443.
Decay accelerating factor ( DAF, CD55) and membrane co-factor protein ( MCP, CD46) act at the level of the C3 convertase enzymes which activate C3 to C3b. Paper-7370954.
CD3/ CD46- activated Tregs adhere to/roll on MAdCAM-1-expressing HeLa cells, similar to T cells isolated from the human lamina propria (LP). Paper-12900951.
In the present study, we investigated the expression of MCP, DAF and CD59 in the endothelium of lesional and non-lesional skin of patients with localized morphoea. Paper-8226775.
Differential expression of complement regulatory proteins decay-accelerating factor ( CD55), membrane cofactor protein ( CD46) and CD59 during human spermatogenesis. Paper-8222955.
GC infection causes c- Yes to aggregate in the host cell cortex beneath adherent bacteria, increases binding of c- Yes to CD46, and stimulates c- Yes kinase activity. Paper-9158171.
We have established an ELISA for determination of membrane cofactor protein ( MCP, CD46) both solubilized from cell membranes and released in body fluids. Paper-7276877.
Expression of complement membrane regulators membrane cofactor protein ( CD46), decay accelerating factor ( CD55), and protectin ( CD59) in human malignant gliomas. Paper-554586.
Expression of complement regulatory proteins [membrane cofactor protein ( CD46), decay accelerating factor ( CD55), and protectin ( CD59)] in endometrial stressed cells. Paper-9819725.
Sections were examined by immunofluorescence with monoclonal antibodies to protectin ( CD59), decay accelerating factor ( DAF), and membrane cofactor protein ( MCP). Paper-1443556.
To analyse the mechanisms involved in these phenomena, P-selectin, ICAM-1, VCAM-1 and MCP- 1 expression were evaluated in HuVEC seeded on the different ECM components. Paper-11993959.
We have described the identification of rat DAF and here describe the cloning of rat MCP from cDNA and genomic libraries, using a probe based on the mouse MCP cDNA sequence. Paper-8298026.
We show that MCP fluorescent intensity is significantly lessened in HIV-infected children and that DAF intensity is similarly lessened in infected children with advanced disease. Paper-264029.
Because of higher N excretion, NH(3) concentration on the dairy barn floor increased ( LCP: 7.1mg of NH(3)/m(3); MCP: 10.4 mg of NH(3)/m(3); HCP: 10.8 mg of NH(3)/m(3)). Paper-15282951.
Recipients of hDAF or hDAF/ hMCP hearts did not differ in their patterns of serum antiporcine antibodies or in plasma levels of the soluble terminal complement complex sC5b-9. Paper-10646983.
These data support a model of direct interaction of CD46 and moesin in the cellular membrane and suggest that this complex is functionally involved in the uptake of MV into cells. Paper-177016.
Using two different substrates, fluid-phase C3b and cell-bound C3b, the cleavage of C3b by MCP and factor I was compared to that by CR1 and factor I under various conditions. Paper-6530316.
Using microarray gene expression profiling, we identified the CD46 gene as a target for activated STAT3 signaling in human breast and prostate cancer cells. Paper-13387598.
Immunofluorescence analysis revealed the presence of CD46 and CD59 on all syncytiotrophoblasts, whereas CD55 was only detected on approximately 30% of the cells. Paper-7551293.
Uncontrolled complement activation is prevented in successful pregnancy by the three regulatory proteins DAF, MCP and CD59 positioned on the surface of trophoblasts. Paper-10835501.
The ADAM10- mediated release of CD46 from apoptotic vesicles may represent a form of strategy to allow restricted complement activation to deal with modified self. Paper-12071259.
These CD3/ CD46- stimulated IL-10-producing CD4+ cells proliferate strongly, suppress activation of bystander T cells and acquire a memory phenotype. Paper-9742394.
Proliferation of this population to generate extra-villous cytotrophoblast cell columns was associated with both an increase in DAF expression and a decrease in MCP expression. Paper-7274721.
MCP purified by immunoaffinity chromatography from both normal and cancer patients' sera consisted of three bands of 56, 47 and 29 kDa on SDS-PAGE/ immunoblotting. Paper-378825.
Furthermore, a cell line lacking DAF (IA10-/D17-) allowed alternative pathway- mediated homologous complement ( C3) deposition after pretreatment with anti- MCP antibody. Paper-7576932.
The immunohistochemically stained membrane cofactor protein of complement ( MCP/ CD46), one of the complement regulatory proteins, was up-regulated in some diseased kidney tissues. Paper-101415.
Assignment of MCP encoding the porcine membrane cofactor protein ( MCP/ CD46) to the long arm of pig chromosome 9 with somatic cell hybrids. Paper-2010542.
It has been thought that the virally induced inhibition of IFN- MCP is secondary to the shutdown of cellular macromolecular synthesis that accompanies cytopathic virus infections. Paper-7586532.
The aim of this study was to analyze expression of complement inhibitors CD46, CD55, and CD59 in patients with CD20(+) NHLs treated with rituximab combined with chemotherapy. Paper-14150106.
Membrane cofactor protein ( MCP, CD46), a widely distributed regulatory protein, inhibits complement activation on host cells and serves as a measles virus receptor. Paper-7946168.
Because IFN- MCP was also blocked in Ad12 E1A-transfected cell lines, expression of one or more of the E1A-conserved regions may be necessary to inhibit IFN- MCP. Paper-7586532.
Immunostaining revealed that DAF, MCP and CD59 are all expressed from at least 6 weeks of gestation in the liver but that these proteins display distinct distribution patterns. Paper-7626443.
DAF, MCP and CD59 are all expressed where trophoblast surfaces are in contact with maternal blood and tissues and expression occurs from at least 6 weeks of gestation. Paper-7370954.
Expression of the complement-regulatory proteins CD55, CD46 and CD59 are deregulated in cancer with tumors showing loss of one or more inhibitors and strong overexpression of others. Paper-9147210.
Infection of target cells with cytopathic viruses inhibits IFN induction of cytolytic resistance to NK cell-mediated cytolysis [ IFN-mediated cytoprotection ( IFN- MCP)]. Paper-7586532.
However, whilst a limited protective role was seen for MCP, CD59 and DAF appeared to be of far more importance for protection from complement-mediated lysis via the classical pathway. Paper-422386.
Prior to this maturation stage, Mphi expressed sufficient amounts of CD9 and CD46 but showed no such complex formation, and as in intact monocytes MV replication was markedly suppressed. Paper-9195287.
This study determined if the Ad5-induced inhibition of IFN- MCP was independent of adenovirus (Ad) infection and secondary only to the expression of the Ad early region 1A gene (E1A). Paper-7586532.
Because expression of mCRP may limit a complement-mediated anti-tumor response, we determined whether complement deposition was associated with the expression level of CD46, CD55, and CD59. Paper-2162278.
In this study, we used an indirect fluorescent immunostaining to investigate the distribution of complements, MCP, DAF, and CD59, in the villi before the 10th week of pregnancy in 18 women. Paper-7578025.
Primary fetal human astrocytes and an astrocytoma cell line, U373-MG, expressed membrane cofactor protein ( CD46), CD59, and low levels of decay-accelerating factor ( CD55). Paper-821171.
About 60% of non-Stx-associated aHUS are due to the defect of protection of endothelial cells from complement activation, secondary to mutations in the genes of CFH, MCP, IF, BF, or C3. Paper-12977654.
CD46 expression was decreased on tumor cells; in contrast, CD55 was expressed on tumor cells (12 out of 31 samples), while it was not detected on proximal tubular epithelial cells (PTEC). Paper-2162278.
It is concluded that in this pig-to-baboon heterotopic heart transplant, model expression of hDAF/ hMCP does not provide an additional benefit in prevention of rejection to that of hDAF alone. Paper-10646983.
Furthermore, when these cells were transfected to express human CD46, a 100-fold increase in syncytium formation was observed with these cells and was independent of the expression of moesin. Paper-1307074.
CD46 mRNA expression is induced by interleukin-6 and by transient transfection of normal human epithelial cells with a persistently active mutant construct of STAT3, STAT3C. Paper-13387598.
For the combinated expression of human CRPs in transformed pig cells, cDNAs of human DAF, MCP, and CD59 were cloned into the same insertional plasmid under the control of pCMV IE and LTR. Paper-12049282.
Research on membrane complement inhibitors ( DAF, MCP, and CD59) has led to understanding of the regulation of complement system; however, their precise role and distribution remain speculative. Paper-7578025.
Throughout placental development, expression of DAF appeared to be lower than that of MCP and CD59 as assessed by solid-phase binding assays on isolated trophoblast membranes. Paper-7274721.
Membrane cofactor protein ( MCP; CD46), a widely distributed regulator of complement activation, is a cofactor for the factor I-mediated degradation of C3b and C4b deposited on host cells. Paper-8578703.
Regulation of proteolytic activity of complement factor I by pH: C3b/C4b receptor ( CR1) and membrane cofactor protein ( MCP) have different pH optima for factor I-mediated cleavage of C3b. Paper-6530316.
The complement regulatory proteins CD55 (decay accelerating factor) and CD59 are expressed on the inner acrosomal membrane of human spermatozoa as well as CD46 (membrane cofactor protein). Paper-12060338.
The combination of tumour necrosis factor-alpha, IL-1beta, and IL-6 caused increased expression of CD55 (three-fold) and CD59 (two-fold) and decreased expression of CD46 at day 3 post-exposure. Paper-8372634.
While the risk of post-transplant recurrence is less than 1% in Stx-HUS patients, it is approximately 80% in CFH or IF-mutated patients, 20% in MCP-mutated patients, and 30% in patients with no mutation. Paper-12977654.
Serum levels of MCP-1 were measured in children with and without asthma in order to determine a possible correlation between the MCP-1-2518A/G polymorphism, serum levels of MCP-1 and asthma. Paper-12050397.
The ECs expressing both DAF and MCP proteins or both DAF and CD59 proteins exhibited more protection against cytolysis by human serum compared to the cells with only DAF expressed alone. Paper-8872872.
Interestingly, both DAF and MCP, which inhibit complement activation at C3/ C4 level, were not expressed in the apical portion of the tubular cells including proximal tubule brush border. Paper-8227321.
While MCP-mutated patients can reasonably go to transplantation, recent reports suggest that plasmatherapy started before surgery and maintained life-long may prevent recurrence in CFH-mutated patients. Paper-12977654.
PS/gammaS processing of CD46 releases immunoprecipitable cyt1 and cyt2 tail peptides into the cell, is blocked by chemical inhibitors, and is prevented in dominant negative presenilin mutant cell lines. Paper-14200458.
Interestingly, down-regulation of CD46 alone is sufficient to confer susceptibility of cells to complement lysis despite the continued surface expression of other RCA proteins such as CD35 and CD55. Paper-221518.
Expression of the complement-regulatory proteins ( CRP) CD46, CD55 and CD59 represents a strategy used by tumor cells to evade complement-dependent cell cytoxicity stimulated by monoclonal antibodies. Paper-10774366.
Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome. Paper-14088795.
This study is the first report demonstrating that HHV-7 infection causes elevation of the CRPs CD46 and CD59, which may be a possible mechanism for HHV-7 to evade humoral immunity via complement. Paper-13173665.
Immunohistochemistry was performed on all tissue samples, using monoclonal antibodies to membrane cofactor protein ( MCP), decay accelerating factor ( DAF), CD59 and complement receptor 1 ( CR1). Paper-418381.
Three Holstein mid to late lactating cows were confined in separate tie-stalls and randomly assigned to 3 diets with varying CP content [low CP ( LCP): 14.1%; moderate CP ( MCP): 15.9%; high CP ( HCP): 16.9%]. Paper-15282951.
This DAF-TM construct used the TM and cytoplasmic domains of membrane cofactor protein ( MCP); an alternate TM version of DAF constructed with the TM and cytoplasmic domains of HLA-B44 showed equivalent protection. Paper-6928999.
Paired samples of tumor and normal tissue from 22 bladder cancer patients were analyzed for expression of MUC1, CD46, CD55 and CD59, and matched serum samples analyzed for anti-MUC1 IgM and IgG levels. Paper-12939305.
These data establish that soluble forms of MCP are present in human sera that possess cofactor activity and their concentrations, especially the 56 and 47 kDa forms, are increased in sera of cancer patients. Paper-378825.
Typical CD59 and MCP components were observed in fetal liver extracts by immunoblotting, although liver MCP components consistently migrated 4000-5000 MW ahead of those observed on placental trophoblast. Paper-7626443.
Complement factor H ( CFH), factor I, and membrane cofactor protein ( MCP; CD46), 3 regulators of the alternative pathway of the complement system activation, have been implicated in this pathological state. Paper-12934137.
However, when fecal and urinary samples were incubated at 4, 19, and 29 degrees C in the laboratory, ammonia concentration increased for all diets, especially for the MCP and HCP diets, as the temperature increased. Paper-15282951.
The human complement RCA proteins analyzed were factor H ( FH), C4 binding protein alpha chain, membrane cofactor protein ( MCP), decay accelerating factor (DAF), and complement receptors type 1 ( CR1) and 2 (CR2). Paper-10746585.
Functional modulation of human macrophages through CD46 ( measles virus receptor): production of IL-12 p40 and nitric oxide in association with recruitment of protein-tyrosine phosphatase SHP-1 to CD46. Paper-8594490.
There was a significant difference in the intensity of the staining of CD55 and CD46 among cells in various layers of normal esophageal mucosa and esophageal carcinoma cells, but not in the staining of CD59. Paper-10439547.
Chemical cross-linking of cell surface proteins indicated the close proximity of CD46 and moesin in the membrane of human cells, and coimmunoprecipitation of moesin with CD46 suggested their physical interaction. Paper-177016.
Moesin, and not the murine functional homologue ( Crry/ p65) of human membrane cofactor protein ( CD46), is involved in the entry of measles virus (strain Edmonston) into susceptible murine cell lines. Paper-318000.
Mouse cells ubiquitously express CRRY, which is a functional orthologue of human decay-accelerating factor ( DAF; CD55) and membrane cofactor protein ( MCP; CD46), and thus protects cells from homologous complement. Paper-9563811.
Application of Spearman rank correlation test revealed CD46 expression was significantly associated with expression of ER at the level of protein (p = 0.031; r = 0.31) and mRNA (p < 0.001; r = 0.52). Paper-10216153.
Using chimeric molecules composed of different combinations of the short consensus repeat domains (SCRs) of DAF and membrane cofactor protein ( CD46), we show that sequences in SCR1 of DAF are essential for EV70 binding. Paper-1602331.
Whereas DAF and CD59/ HRF20 were present only occasionally on the apical surfaces of normal epithelial cells, MCP was diffusely distributed on the basolateral surfaces of most epithelial cells of the colon. Paper-167209.
MCP was generally observed basolaterally on all epithelial cells, whereas apical protectin expression was more intense on the epithelium of normal colonic mucosa than in the normal duodenum (p = 0.001). Paper-1443556.
To investigate the localization of CD46 and moesin, which are receptors for measles virus, Caco-2 cells were incubated with monoclonal antibodies against CD46 or moesin followed by 125I-labeled anti-mouse Ig. Paper-265248.
Complement regulatory proteins at the feto-maternal interface during human placental development: distribution of CD59 by comparison with membrane cofactor protein ( CD46) and decay accelerating factor ( CD55). Paper-7274721.
These results strongly suggest complement regulation by CMV virions that is modulated by anti-CMV antibody; this regulation may be attributed to three host complement regulators on the virions: CD55, CD46, and CD59. Paper-1109277.
This study investigated whether the coexpression of human decay-accelerating factor ( hDAF) and human membrane cofactor protein ( hMCP) on porcine organs provides an additional benefit to that of hDAF alone to prevent rejection. Paper-10646983.
Mouse cells expressing the human complement regulatory proteins decay accelerating factor ( DAF) or membrane cofactor protein ( MCP) were produced both by hybridoma technology and by transfection with the appropriate cDNAs. Paper-11728857.
Mouse cells expressing the human complement regulatory proteins decay accelerating factor ( DAF) or membrane cofactor protein ( MCP) were produced both by hybridoma technology and by transfection with the appropriate cDNAs. Paper-368157.
METHODS: Infarct volume and total intracranial volume were measured with Leica Q500 MCP image analysis software, or with a caliper, on 38 CT scans of patients who participated in the Tirilazad Efficacy Stroke Study II ( TESS II). Paper-8764096.
These findings indicated that these complement inhibitors played an important role in early pregnancy, and that CD59 continued to appear in early pregnancy, whereas the expression of MCP and DAF depended on the stage of pregnancy. Paper-7578025.
We investigated the functional consequences of binding of monoclonal antibodies to both molecules individually and combined on MV attachment, fusion, and plaque formation and the putative direct physical interaction of moesin and CD46. Paper-177016.
Moesin-negative ES cells expressing or not expressing human CD46 formed separate pieces of fragmented syncytia which were torn apart during spreading, whereas ES cells expressing moesin exhibited typical syncytia. Paper-1307074.
Here, we found that peripheral blood monocytes treated for 5--8 days with GM-CSF (i.e. mature Mphi) acquired the capacity to assemble CD9, alpha3-beta1 integrin and the tyrosine phosphatase SHP-1 with their CD46. Paper-9195287.
Three of the proteins protecting cells from autologous lysis by complement are: membrane cofactor protein ( MCP; CD46), an inhibitor of the membrane attack complex formation ( CD59), and decay accelerating factor ( DAF; CD55). Paper-1612917.
Recently, two cellular membrane proteins, the membrane cofactor protein CD46 and the membrane-organizing external spike protein, moesin, have been identified to be functionally associated with measles virus (MV) infectivity of cells. Paper-177016.
In this report we describe our efforts to solve the structures of human membrane cofactor protein ( CD46), the vaccinia virus complement control protein, which mimics mammalian RCA proteins, and human complement receptor type 1 ( CD35). Paper-10675745.
These data suggest either that GPI-anchored and TM versions of a protein have equal lateral mobility in the membrane, or else that increased lateral mobility is not advantageous to DAF or MCP in carrying out their complement inhibitory roles. Paper-6928999.
Recently, we have shown undetectable or decreased expression of complement regulatory molecules, membrane cofactor protein ( MCP) and decay-accelerating factor ( DAF), in cutaneous endothelium of patients with systemic sclerosis (SSc). Paper-8226775.
Adenovirus-mediated gene transfer of triple human complement regulating proteins ( DAF, MCP and CD59) in the xenogeneic porcine-to-human transplantation model. Part II: xenogeneic perfusion of the porcine liver in vivo. Paper-9162945.
We have produced and tested the function of novel recombinant chimeric proteins that incorporate the functional domains of both CD46 (membrane cofactor protein, MCP) and the low affinity human IgG receptor FcgammaRII ( CD32). Paper-2191787.
When melanocytes were sensitized with autoantibody as well as F(ab')2 fragment of either anti- MCP or anti- DAF and subsequently incubated with NHS or GpS, both antibody fragments increased the killing of melanocytes by NHS as well as by GpS. Paper-1389598.
Furthermore, we show that inhibition of STAT3- mediated CD46 cell surface expression sensitizes DU145 prostate cancer cells to cytotoxicity in an in vitro complement lysis assay using rabbit anti-DU145 antiserum and rabbit complement. Paper-13387598.
CONCLUSION: The complement regulatory proteins MCP, DAF, and CD59 are expressed throughout the female genital tract, and may thus play an important role in protecting the traversing sperm and implanting blastocyst from complement mediated damage. Paper-418381.
Furthermore, DAF and MCP demonstrated approximately equal protection of cells from complement-mediated cytotoxicity, suggesting that DAF and MCP provide overlapping levels of protection to cells against damage mediated by the complement system. Paper-6928999.
Flow-cytometric analysis revealed that upregulation of CD46 occurred at a late stage of infection in both SupT1 cells and primary CD4+ T cells, and also that expression of another CRP, CD59, was increased at a late stage of infection. Paper-13173665.
CD46 exhibited the most striking pattern of association, with increased levels of expression being associated with ER-positive samples and lower levels of expression associated with a loss of differentiation and epidermal growth factor receptor positivity. Paper-10216153.
Biochemical, molecular, and immunohistologic studies have identified membrane cofactor protein ( MCP) and decay accelerating factor ( DAF) on trophoblast cells, which could assist in preventing lysis of the cells by complement-activating maternal antibodies. Paper-6956080.
These studies were performed to examine whether alterations in the cell-surface complement regulatory proteins decay-accelerating factor ( DAF, CD55) and membrane cofactor protein ( MCP, CD46) may occur during HIV infection in vitro or in vivo. Paper-264029.
Endometrial cells are protected from autologous complement attack by membrane-bound complement regulatory proteins (CRPs) that prevent complement activation: membrane cofactor protein ( CD46), decay accelerating factor ( CD55), and protectin ( CD59). Paper-9819725.
BACKGROUND: Although included in successive editions of the DSM since its introduction in the IIIrd, the subtyping of manic episode into 'with mood-congruent ( MCP) versus mood-incongruent ( MIP) psychotic features' is yet to be fully validated. Paper-12345333.
An enzyme linked immunosorbent assay ( ELISA) has been developed for the quantitative determination of the most probable contaminating proteins ( MCP) of recombinant human Erythropoietin produced in the mouse fibroblast cell line C-127. Paper-6638487.
We show that novel, low MW forms of MCP and DAF are expressed in normal testis membranes but are absent from testis membranes obtained from patients undergoing gender reassignment surgery in whom the germinal epithelium is diminished. Paper-8222955.
To assess how the kidney is protected from the autologous complement attack, comparative localization of decay accelerating factor ( DAF), membrane cofactor protein ( MCP) and 20 kDa homologous restriction factor ( HRF20) was studied in the normal human kidney. Paper-8227321.
CD46 associated in part with several tetranspans and with all beta1 integrins that were tested ( CD29/ CD49a, CD29/ CD49b, CD29/CD49c, CD29/CD49e, CD29/CD49f) but not with beta4 integrins. Paper-2168917.
Interleukin-1beta (IL-1beta) consistently downregulated the expression of CD46 and CD59; IL-4 consistently downregulated the expression of CD46 and transforming growth factor-beta1, consistently downregulated the expression of both CD46 and CD55. Paper-9728408.
We report that anti-moesin monoclonal antibodies 119 and 38/87 reduce the number of infectious centres attributed to MV in murine cell lines NS20Y and L929, whereas polyclonal antisera specific for Crry/ p65 and CD46 had no effect on MV infection of these cells. Paper-318000.
To address this question, the expression levels of CD46, CD55, and CD59 were measured semi-quantitatively in situ on renal cell carcinomas and compared with the expression level and cellular distribution of these mCRP in proximal tubuli within each patient (n = 31). Paper-2162278.
These results show that activated STAT3 signaling induces the CD46 promoter and protects human cancer cells from complement-dependent cytotoxicity, suggesting a potential mechanism whereby oncogenic signaling contributes to tumor cell evasion of antibody-mediated immunity. Paper-13387598.
We have examined the distribution of the complement (C) regulatory proteins CD59, membrane cofactor protein ( MCP) and decay-accelerating factor ( DAF) on mature sperm and compared expression of these proteins in parallel both during spermatogenesis and in the prostate. Paper-8222955.
Here, we highlight new advances in the field, emphasising the interaction between MV proteins and their cellular targets, in particular the cell membrane receptors, CD46, CD150, TLR2 and FcgammaRII in the induction of immunological abnormalities associated with measles. Paper-11775142.
These results are in agreement with the data obtained with human leukaemia cell lines, and support the hypothesis that CR1 is essentially a differentiated cell antigen and that a high level of MCP reflects some malignant transformation or an immature stage in blood cells. Paper-7496157.
METHODS AND RESULTS: In the normal esophageal mucosa, CD55 predominantly stained on the cell membrane of squamous epithelium in the superficial and prickle cell layers, whereas CD46 most intensely stained on the cell membrane in the basal and parabasal cell layers. Paper-10439547.
METHODS: In this study, we assessed the capacity of brain epithelial cells to express membrane-bound complement regulators (ie, CD35, CD46, CD55 and CD59) in vitro and in situ by immunostaining of control and meningitis human brain tissue sections. Paper-12243064.
METHODS: We investigated the expression pattern of CD46, CD55, CD59, and CD97 (a receptor for CD55) in prostate cancer by tissue microarray analysis using high-density tissue microarrays spotted with tissue cores from biopsy and autopsy specimens. Paper-11499129.
The complement regulatory proteins CD55 and CD59 are expressed on the plasma membrane of human spermatozoa, whereas CD46 is only on the inner acrosomal membrane (IAM) which becomes surfaced exposed after the acrosome reaction when sperm assume fertilisation-competence. Paper-12060338.
In 25 cell lines (10 adenocarcinoma, 3 large-cell carcinoma, 7 small-cell lung cancer [ SCLC], and 5 squamous cell carcinoma), flow cytometric analysis revealed that MCP was expressed in all cell lines, whereas none of the cell lines was CR1-positive. Paper-7576932.
Enhanced immunoperoxidase staining and radioimmunoassay confirmed that C regulators are differentially expressed on sperm; CD59 was strongly expressed on the surface of acrosome intact sperm while MCP and DAF appear to be located primarily on the inner acrosomal membrane. Paper-8222955.
To escape complement-mediated lysis, HIV has adopted various properties, which include the acquisition of HIV-associated molecules (HAMs) belonging to the family of complement regulators, such as CD46, CD55, CD59, and the interaction with humoral regulatory factors like factor H (fH). Paper-10776380.
They participate the pathological process through the synthesis and secretion of pro-inflammatory cytokines, including interleukin 1 ( IL1), IL6, IL8, and the three colony stimulating factors G-CSF, M-CSF, and GM-CSF and the two chemotactic factors gro-alpha and MCP. Paper-525012.
As several reports have supported an association of HHV-6 and multiple sclerosis, it was of interest to compare levels of soluble CD46 in the sera of multiple sclerosis patients to that of healthy controls, other neurological disease controls, and other inflammatory disease controls. Paper-9076653.
We here demonstrate that expression of the C inhibitors decay-accelerating factor ( DAF), membrane cofactor protein ( MCP) and CD59 was unaltered on K562 after non-lethal C attack and that neutralization of these inhibitors with specific blocking antibodies did not reverse the induced resistance. Paper-1031179.
Flow cytometry analysis demonstrated uptake of acetylated low density lipoproteins (Ac-LDL) and constitutive expression of SLA class I, CD29, CD31, CD41/61, CD80/86, CD46, SWC3, and LAMP-1 antigens by all analyzed lines and showed little differences to primary cells. Paper-9547177.
Complement activation in turn may be regulated by various means including specific plasma or membrane proteins [e.g. decay-accelerating factor ( DAF), membrane cofactor protein ( MCP), membrane inhibitor of reactive lysis ( MIRL), C8-binding protein (C8bp, homologous restriction factor hrf)]. Paper-214872.
The distribution of affected joints was as follows: hip joint (7 cases), knee joint (2 cases), ankle joint (2 cases); iliosacral joint (2 cases), lumbar spine (2 cases), carpus (2 cases), shoulder (1 case), second metacarpal ( MCP; 1 case) and first metatarsal ( MTP; 1 case). Paper-384163.
The particles entered the lymphatic cells exclusively through the signaling lymphocyte activation molecule (SLAM, CD150), whereas particles pseudotyped with the MV vaccine strain glycoproteins also recognized the ubiquitous membrane cofactor protein ( CD46) as receptor and had less specific cell entry. Paper-13769594.
As the complement regulatory proteins CD46 and CD59 are also strongly expressed by trophoblast at the feto-maternal tissue interface, these results support the concept that similar mechanisms are employed both by the genetically dissimilar fetus and certain tumours to evade immune attack by their host. Paper-1612917.
RESULTS: Double immunofluorescence experiments for ependymal cell markers ( GFAP, S100, ZO-1, E-cadherin) and complement regulators indicated that the human ependymal cell line model was strongly positive for CD55, CD59 compared to weak stainings for CD46 and CD35. Paper-12243064.
The human fetus appears to be capable of protecting itself from maternal complement (C) from an early stage in development by expressing the C regulatory proteins decay-accelerating factor ( DAF), membrane co-factor protein ( MCP) and CD59 on fetally derived trophoblast at the feto-maternal interface. Paper-7626443.
Using fluorescent labeling, ultracentrifugation, and density gradient centrifugation, virtually all CD46 was present on prostasomes whereas CD59, CD55, AND CDw52 were also detected in a form which remained in the 200,000 g supernatant and equilibrated at higher density than prostasomes in gradients. Paper-516436.
BACKGROUND: Altered expression of three complement regulatory proteins, decay-accelerating factor ( CD55), membrane cofactor protein ( CD46) and homologous restriction factor 20 ( CD59) has been identified in human gastrointestinal malignancies, but their expression in esophageal cancer has not been described. Paper-10439547.
We found that engagement of CD46-1 or CD46-2 differentially affected CD8(+) T cell cytotoxicity, CD4(+) T cell proliferation, interleukin 2 ( IL-2) and IL-10 production as well as tyrosine phosphorylation of Vav in T lymphocytes. Paper-9214169.
Analysis of the correlation of each antibody with the expression of each complement inhibitor by Spearman's rank test revealed a strong correlation between both anti-MUC1 IgM and IgG levels and increased expression of CD46 and CD55, and combined anti-MUC1 IgM/IgG levels correlated with increased expression of all 3 complement inhibitors. Paper-12939305.
Immunohistochemical and immunoelectron microscopic localization of complement components, C3d and C5b-9, and the complement-regulatory factors, such as s-protein, decay-accelerating factor (CD55), membrane cofactor protein ( CD46), complement receptor types 1 ( CD35) and 2 ( CD21), and protectin ( CD59), were examined in these tissues. Paper-8226685.
Herein, we report that cell surface expression of two complement regulator proteins, CD55 and CD46, which are members of the regulators of complement activation (RCA) gene cluster, increased up to eightfold following infection of fibroblasts or glioblastoma cells with HCMV, but not after infection with HSV-1 or adenovirus. Paper-624554.
The complement (C) regulatory proteins decay-accelerating factor ( DAF, CD55) and membrane cofactor protein ( MCP, CD46), which control C3 convertases, together with CD59, an inhibitor of the membrane attack complex (MAC), were found to be present in the developing human placenta from at least 6 weeks of gestation until term. Paper-7274721.
The authors established several swine endothelial cell (SEC) lines expressing human CD59 by transfection of cDNA, and assessed the function of the transfectant molecules in comparison with those of membrane cofactor protein ( MCP) and decay-accelerating factor ( DAF) in an in vitro hyperacute rejection model of swine to human discordant xenograft. Paper-576004.
With this in mind, we have examined a new human colon cancer cell line (LIM1899) which has a heterogeneous expression of several cell surface molecules: by flow cytometry 38% were carcinoembryonic antigen positive; 64%, human milk fat globule positive, and 73%, CD46 positive; 87% of tumor cells bound a mixture of all three antibodies in vitro. Paper-6713634.
These synonyms are used for gene CD46 (CD46 molecule, complement regulatory protein): Trophoblast leukocyte common antigen, TRA2.10, TLX, MIC10, MGC26544, Membrane cofactor protein, MCP, AHUS2.
These accession numbers are used for gene CD46: Y00651 (NCBI_GENBANK__AC), X59406 (NCBI_GENBANK__AC), Q9NNW4 (UNIPROT__AC), Q5VWS8 (UNIPROT__AC).
CD46 is a homologue of CD46 (CD46 molecule, complement regulatory protein) from Pan troglodytes.
CD46 is a homologue of CD46 (CD46 molecule, complement regulatory protein) from Canis lupus familiaris.
CD46 is a homologue of CD46 (CD46 molecule, complement regulatory protein) from Bos taurus.
CD46 is a homologue of Cd46 (CD46 antigen, complement regulatory protein) from Mus musculus.
CD46 is a homologue of Cd46 (CD46 molecule, complement regulatory protein) from Rattus norvegicus.
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iHOP - Information Hyperlinked over Proteins .
Concept & Implementation by Robert Hoffmann.