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The myeloperoxidase gene in acute promyelocytic leukemia. Paper-11967677.
Neither PR3 nor MPO elicited significant IL-2 production. Paper-9513342.
NSE, MPO, and MDA serum levels did not differ among groups. Paper-9976532.
HMW- APN correlates positively with MPO in patients with type 2 diabetes. Paper-14465049.
Low leucocyte myeloperoxidase activity in patients with multiple sclerosis. Paper-9741179.
Interaction of ceruloplasmin, lactoferrin, and myeloperoxidase. Paper-13246481.
Some cells lining the sinus lumen expressed CD68, lysozyme and myeloperoxidase. Paper-8343241.
Furthermore, myeloperoxidase colocalized with human leukocyte elastase. Paper-2024331.
PLG-AT, PLG-BT, and PRP showed a comparable, gradually increasing MPO release. Paper-12749253.
7. MPO, urokinase, XPA and XPD in both groups were non-significantly different. Paper-15285896.
Novel markers of tissue injury ( FABP, PAPP-A, or MPO) are the earliest markers to rise. Paper-15448098.
MPO cytochemistry was also associated with immunologic detection of LF. Paper-4884486.
MPO is expressed in macrophages-microglia in multiple sclerosis ( MS) lesions. Paper-8488800.
CP subjected to partial proteolysis was virtually unable to inhibit activity of MPO. Paper-13503432.
PMN were activated by IL-8 and secreted hydrogen peroxide and myeloperoxidase ( MPO). Paper-1816210.
Sputum NE/AAT complex and MPO levels were lower on rAAT compared to placebo. Paper-11324331.
These peptides are able to displace CP from its complexes with LF and MPO. Paper-13246481.
Alterations in MBP did not occur in CO-poisoned knockout mice lacking MPO. Paper-12319070.
We hypothesized that infections may trigger the ANCA response against MPO through hHSP60. Paper-12163542.
Antineutrophil cytoplasmic antibodies and antibodies to myeloperoxidase in rheumatoid arthritis. Paper-7165095.
NADH-oxidase, NADPH-oxidase and myeloperoxidase activity of visceral leishmaniasis patients. Paper-9586370.
Only six of 15 ANCA-positive sera reacted with myeloperoxidase and four of 15 with lactoferrin. Paper-1645331.
SP-A and SP-D inhibit binding of an anti- MPO monoclonal Ab to late apoptotic cells. Paper-15575299.
Estrogen blocked PPARgamma effects on MPO expression, especially for the A allele. Paper-10205399.
GCF samples were assayed for the enzymes NE, BG, MPO and the cytokines IFN-alpha and IL-1 alpha. Paper-1318662.
RESULTS: Episodic increases in CRP were accompanied by higher levels of VEGF, sICAM and MPO. Paper-12366540.
These data suggest that low MPO, which may be genetically determined, plays a part in MS pathogenesis. Paper-9741179.
Disorders of phagocyte killing and digestion ( CGD, G-6-PD and myeloperoxidase deficiencies). Paper-6478069.
MPO/H2O2- mediated cytotoxicity of CF sputum was measured in cell culture assays. Paper-1439330.
MMP-1 and -8 may have been activated by MMP-3 and/or oxidants generated by myeloperoxidase. Paper-1016121.
The two main targets of ANCA in vasculitis are proteinase 3 ( PR3) and myeloperoxidase ( MPO). Paper-389256.
Six sera reacted to BPI, five to LF, one to MPO, one to PR3, and one to CG by ELISA testing. Paper-11447305.
In CF sputum samples, activities and concentrations of MPO and catalase (CAT) were determined. Paper-1439330.
RESULTS: DSS increased DAI, MDS, MPO activity and TNF-alpha production and decreased CH. Paper-9578317.
There were strong correlations between the concentration of bFGF and the concentrations of MPO and IL-6. Paper-8429167.
Overall, both MPO- and LF-ANCA were found mainly in RA, SLE, and PSS patients but not in PM/DM patients. Paper-8543305.
Both human and canine MPO could form a complex when mixed with CP from seven mammalian species. Paper-13246481.
Enzymatic inactivation of human alpha-1- proteinase inhibitor by neutrophil myeloperoxidase. Paper-3349686.
Myeloperoxidase-dependent inactivation of surfactant protein D in vitro and in vivo. Paper-15125474.
Myeloperoxidase mediates neutrophil activation by association with CD11b/ CD18 integrins. Paper-11187971.
CYP1B1, CYP1A1, MPO, and GSTP1 polymorphisms and lung cancer risk in never-smoking Korean women. Paper-14391577.
Lactoferrin co-purifies with myeloperoxidase and is recognised by anti-neutrophil cytoplasm antibodies. Paper-7652939.
Similarly, the MPO ab reactivity of patients with systemic vasculitis could not be inhibited by native TPO. Paper-1106512.
Genotype frequencies were similar for MTHFR (A1298C), MPO (C(-)463T), and XRCC1 (Arg280His, Arg399Gln). Paper-10316527.
The expression of CD14 and MPO in HL-60 leukemia cells overexpressing GMPR2 clearly increased after induction by TPA. Paper-9695502.
Immunohistochemistry for myeloperoxidase ( MPO), SP, and VIP was performed in whole mount sections. Paper-13204228.
They incorporated data on two biologically relevant polymorphic genes, matrix metalloproteinase-1 and myeloperoxidase. Paper-10791251.
CONCLUSIONS: MPO genotype GG is associated with cirrhosis in patients with hereditary hemochromatosis. Paper-10793652.
LY-83583 (100 microM) inhibited the release of both LF and MPO after stimulation with FMLP or A-23187. Paper-7727719.
While immunogold labeling of PDE4A was reduced after fMLP stimulation, staining of MPO-containing granules remained high. Paper-9925425.
Preincubation of HUVEC monolayers with PR3 or MPO resulted in a dose-dependent binding of both PR3 and MPO. Paper-8049921.
In addition, iNOS protein expression was significantly enhanced in TKTL1(-/-) mice as well as MPO activity. Paper-15795813.
No differences in IL-6, TNF-alpha, MPO or histamine levels between patients and healthy volunteers were observed. Paper-8803167.
These data indicate the LPO heme is distinct from heme b of Mb and HRP as well as from "heme m" of MPO. Paper-547643.
Myeloperoxidase-derived oxidants selectively disrupt the protein core of the heparan sulfate proteoglycan perlecan. Paper-14166669.
Association of genetic polymorphisms in CYP2E1, MPO, NQO1, GSTM1, and GSTT1 genes with benzene poisoning. Paper-9332803.
Immunohistochemical studies showed intense immunoexpression for CD43, CD68, CD45RO and myeloperoxidase within these cells. Paper-12855806.
(4) Several structurally deviated segments were identified by a structural comparison between cyclooxygenase and myeloperoxidase. Paper-8748577.
Polyclonal antibodies to both LF and MPO displace the respective proteins from the CP- LF- MPO complex. Paper-13246481.
Detection of myeloperoxidase by flow cytometry in acute lymphoblastic leukaemias with BCR- ABL gene rearrangement. Paper-8913406.
Genotyping was done using PCR and gel electrophoresis for MPO and NQO1 and using MALDI-TOF mass spectrometry for SOD2. Paper-10313181.
Genomic DNA was hybridized simultaneously with probes corresponding to portions of HER-2/neu and a single-copy gene, myeloperoxidase. Paper-101712.
Tyrosine modification is not required for myeloperoxidase- induced loss of apolipoprotein A-I functional activities. Paper-11070740.
T cells recognize epitopes in the MPO-like region but not in the CCP- or EGF-like regions in humans. Paper-12540120.
Alpha-1-antitrypsin ( alpha 1AT) is the major physiological inhibitor of PR3, while MPO is an inhibitor of alpha 1AT. Paper-615949.
MPO and caspase-3 enzyme activity levels were significantly reduced in animals treated either with r-Hu- EPO or MPSS. Paper-13138604.
Xanthine oxidase (XO), myeloperoxidase ( MPO) and adenosine deaminase ( ADA) activities were also evaluated in the same samples. Paper-12944553.
Indeed, anti- MPO IgG induced secretion of KC and MIP-2, leading to neutrophil chemotaxis in vitro. Paper-16230470.
In this study, we have investigated the genetic role of the myeloperoxidase ( MPO) gene encoding myeloperoxidase in MS. Paper-13328542.
Flow cytometry showed that p38- MAPK inhibition decreased the translocation of PR3 (by 93 +/- 2%) and of MPO (by 64 +/- 2%). Paper-8774777.
Candidates include genetic variants of glutathione S-transferases ( GSTM1, GSTT1 and GSTP1) and myeloperoxidase ( MPO). Paper-10823008.
Anti- myeloperoxidase (MPO)-ANCA are a typical feature of MP and CSS, while anti- proteinase 3 (PRTN3)-ANCA are highly specific for WG. Paper-9056317.
Genetic polymorphisms of MPO, COMT, MnSOD, NQO1, interactions with environmental exposures and bladder cancer risk. Paper-10295990.
HES also decreased the number of MPO-positive cells induced by LPS and inhibited activation of NF-kappaB and AP-1. Paper-11766317.
CK1 interacts with MPO in vitro, even in the presence of 100% human plasma, thus substantiating biological relevance. Paper-13298693.
The concentrations of XDH, XOD and alpha-amylase in plasma and AF and myeloperoxidase ( MPO) in lung have been evaluated. Paper-10309651.
The possible protein-protein interface is comprised of the area near active site of MPO and the loop linking domains 5 and 6 in CP. Paper-13503432.
Anti- ECP antibodies reacted with both eosinophils and neutrophils and anti- MPO antibodies with neutrophils and monocytes. Paper-9444543.
TNF-alpha, TNF-beta, IL-6, IL-10, PECAM-1 and the MPO inflammatory gene polymorphisms in osteosarcoma. Paper-13223587.
Conversely, animals receiving recombinant IL-4 and recombinant IL-10 demonstrated reduced permeabilities and lung MPO content. Paper-9915137.
We previously showed that NGAL is sorted to azurophil granules and colocalizes with myeloperoxidase in undifferentiated HL-60 cells. Paper-930423.
Myeloperoxidase delays neutrophil apoptosis through CD11b/ CD18 integrins and prolongs inflammation. Paper-12908983.
Association of the polymorphisms of MTHFR C677T, VDR C352T, and MPO G463A with risk for esophageal squamous cell dysplasia and carcinoma. Paper-12889158.
We also measured nitro-tyrosinylation (NO(2)-Tyr) of LDL as an indicator of biological activity of CRP- mediated MPO release. Paper-13594910.
Moyamoya disease associated with positive findings for rheumatoid factor and myeloperoxidase-anti-neutrophil cytoplasmic antibody. Paper-12639791.
Co-treatment with TNF- binding protein decreased both lung MPO and lung leak increases in rats given TNF intratracheally. Paper-892990.
By contrast, of the 60 sera positive for p-ANCA, 15 (25%) reacted to MPO, 13 (22%) to PR3, eight (13%) to LF, and four (7%) to LZ. Paper-8702027.
MPO polymorphism was assessed by RFLP analysis; HO-1 microsatellite polymorphism by a laser-based semi-automated DNA sequencer. Paper-10793652.
Both EPO and DSP markedly decreased tissue MPO and caspase-3 levels and preserved ultrastructure of the injured brain cortex. Paper-12769177.
The PPARalpha ligand GW9578 downregulates MPO expression in GMCSF-macrophages, while upregulating in MCSF-macrophages. Paper-12230946.
Cotreatment with TNF-alpha and H(2)O(2) promoted apoptotic signaling via MPO activation and subsequent attenuation of FLIP(S) expression. Paper-12532153.
Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer. Paper-15160143.
Possible mitogenic effects of active PR3 and toxic effects of active MPO were excluded by using heat- inactivated PR3 and MPO. Paper-8052294.
TNF-alpha-primed PMN were stimulated with a monoclonal antibody to myeloperoxidase ( MPO) and with PR3- and MPO-ANCA, respectively. Paper-9232838.
RESULTS: Twins with a history of MDD had 32% higher levels of MPO (p < .0001); this difference persisted after adjusting for other risk factors. Paper-12975607.
The occurrence of sensorineural hearing loss in a patient with myeloperoxidase-anti-neutrophil cytoplasmic antibody-related microscopic polyangiitis. Paper-12544349.
MPO secreted from activated phagocytes may also tag phospholipid-containing targets for removal by CD36-positive cells. Paper-8488833.
SB203580 inhibited p38 MAPK and MPO activity, and reduced iNOS, COX-2, and IL-1beta protein or gene expression. Paper-12459496.
LPS injection induced elevated cytokine (IL-1beta and IL-6) secretion and lung MPO activity, which was also attenuated by hANP treatment. Paper-15252157.
Furthermore, in the absence of TGF-beta1, FL consistently promotes generation of LZ+, MPO+, and CD14+ cells, but not of CD1a+ cells. Paper-1145872.
Meanwhile, the levels of plasma amylase, endotoxin, and DAO and the activity of MPO in the intestinal mucosa were rapidly increased after SAP. Paper-14165137.
Five candidate genes were chosen: apolipoprotein E ( APOE), alpha 2-macroglobulin, cathepsin D, myeloperoxidase and nitric oxide synthase. Paper-9729782.
ECP, EDN/ EPX and MPO serum levels reflect the ongoing disease and are related to functional activity of the respective leukopoetic system. Paper-964018.
We found similar release of myeloperoxidase and lactoferrin from granulocytes challenged with serogroup A or W-135 meningococci in either sera. Paper-7016644.
Twenty-three (42%) had anti- Lf antibodies, nine (16%) had anti- MPO and eight (15%) had anti-alpha-antigen antibodies, none of which reacted with PR3. Paper-1983540.
In CD, fecal Lf, PMN-E, and MPO concentrations were high in 19, 10, and 16 samples, respectively, of 30 samples with normal alpha 1-AT concentration. Paper-547350.
In parallel, transcription of the genes for MPO, terminal deoxynucleotidyltransferase ( TdT), CD3-gamma, Ig-mu, TCR-gamma, and beta was also examined. Paper-6219300.
COPD patients had significantly lower CD63 expression and released less MPO upon chemokine stimulation compared with the healthy individuals. Paper-12475445.
Both Trp53 and Mpo have been mapped to human chromosome 17, but the chromosomal assignment of human GFAP has not been previously determined. Paper-42588.
Collectively, these results suggest that MPO-dependent conversion of LDL into a ligand for CD36 is a likely pathway for generating foam cells in vivo. Paper-8488833.
Myeloperoxidase-dependent caspase-3 activation and apoptosis in HL-60 cells: protection by the antioxidants ascorbate and (dihydro)lipoic acid. Paper-9445855.
Of the 21 serum samples positive for c-ANCA, 12 (57%) reacted to PR3, four (19%) to LF, four (19%) to LZ, and three (14%) to MPO on ELISA. Paper-8702027.
Myeloperoxidase plays critical roles in killing Klebsiella pneumoniae and inactivating neutrophil elastase: effects on host defense. Paper-10986726.
The neoplasm was composed predominantly of blasts that expressed CD68, CD117, myeloperoxidase, and lysozyme, with occasional immature eosinophils. Paper-12025064.
The serum concentrations of MPO were measured by enzyme-linked immunosorbent assay ( ELISA) and CRP were measured by turbidimetric immunoassay. Paper-12022175.
Antibodies against SP and MP were produced using bovine milk lactoperoxidase ( LP) and human MP as the immunogens, respectively. Paper-7166380.
Studies on the enzymatic properties shows that CP behaves as a competitive inhibitor impeding the binding of aromatic substrates to the active centre of MPO. Paper-13503432.
Interaction of LF and MPO with CP-Sepharose is blocked at ionic strength above 0.3 M NaCl and at pH below 4.1 ( LF) and 3.9 ( MPO). Paper-13246481.
The aim of this study was to evaluate whether the -463GA MPO promoter polymorphism is linked to clinical severity of CF-associated pulmonary inflammation. Paper-12162053.
CONCLUSIONS: In LJP the concentrations of lysozyme, lactoferrin and myeloperoxidase are significantly elevated in peripheral blood PMNs, also reflected in GCF. Paper-784410.
Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China. Paper-15352369.
Immunohistochemical characterization of the tumors showed expression of CD4, CD56, CD43, and CD123, whereas CD8, CD20, and MPO were negative. Paper-13437001.
CONCLUSION: Polymorphisms in the oxidative stress-related genes ( CYP1A1, GSTM1, GSTT1, MPO, MnSOD) do not seem to be risk factors for preeclampsia. Paper-11292930.
I/ R induced pronounced haemorrhagic intestinal injury accompanied by increase of myeloperoxidase ( MPO) and N-acetyl-β-D-glucosaminidase ( NAGA) activity. Paper-15577973.
Seventeen single nucleotide polymorphisms ( SNPs) were identified in NQO1, CYP2E1, and MPO genes, including 6 novel SNPs in CYP2E1 and MPO. Paper-9332803.
Furthermore, CD63-depleted cells showed a lack of morphologically normal granules, but contained MPO-positive cytoplasmic vacuoles with a lack of proNE and NE. Paper-12956768.
This study assessed the impact of polymorphisms of the MPO (-463G/A) and the HO-1 promotors of Vienna (GT)n on the evolution of cirrhosis in patients with HHC. Paper-10793652.
Formation of this novel class of oxidized PC species contributes to CD36- mediated recognition of LDL oxidized by MPO and other biologically relevant mechanisms. Paper-9171808.
Finally, there was no difference in concentrations of histamine, MPO, ECP, and PAI-1 in samples collected before and after heating of leukofiltered whole blood. Paper-1243042.
At pH 5.5 LP activity was inhibited by 85% and MP by 34% with 10 mM F-. TSP activity was also inhibited only at low pH (5.5) by approximately 25%. Paper-8186601.
Cotyledons of cows with RFM (n = 8) had lower ( P < 0.01) MPO and greater ( P < 0.05) lysozyme and ACP enzyme activities than those from non-RFM cows (n = 6). Paper-11475183.
Then, colonic myeloperoxidase ( MPO) activity, malondialdehyde (MDA) and glutathione (GSH) levels, and Bax and Bcl-2 expression were measured. Paper-12769795.
To test the pathogenic potential of antibodies alone, purified anti- MPO IgG or control IgG was injected intravenously into Rag2(-/-) mice and wild-type mice. Paper-9412803.
CONCLUSIONS: CRP stimulates MPO release both in vitro and in vivo, providing further cogent data for the proinflammatory effect of CRP. Paper-13594910.
Refinement of localization of the human genes for myeloperoxidase ( MPO), protein kinase C, alpha polypeptide, PRKCA, and the DNA fragment D17S21 on chromosome 17q. Paper-50998.
Immunohistochemical stains of the cells indicated a neoplasm of myelomonocytic derivation ( CD4, CD43, CD45, CD68, myeloperoxidase, and lysozyme positive). Paper-12373001.
Intralymphatic mononuclear histiocytes expressed CD68 ( PGM1), although some cases also had variable immunoexpression for myeloperoxidase, CD31, and podoplanin. Paper-13681706.
These results suggest that butyrate induces MPO rather than EPO in EoL-1 cells and that the formation of nitrotyrosine in butyrate- induced cells is dependent on MPO. Paper-10544615.
The ability of lipid-free apoA-I to facilitate ATP-binding cassette transporter A1 cholesterol transport was greatly reduced after chlorination by MPO. Paper-10766500.
MPO-deficient mice showed decreased cross- linking of SP-D and increased SP-D-dependent aggregating activity in the pneumonia model. Paper-15125474.
This resulted in the targeting of NGAL to azurophil granules as demonstrated by colocalization of NGAL with myeloperoxidase, visualized by immunoelectron microscopy. Paper-598964.
Enzyme-linked immunosorbent assay ( ELISA) was applied to estimate MPO, fetuin A, IL-6, and IL-1beta; FPIA was applied for L-homocysteine concentrations. Paper-14071695.
The TaqMan technique was used to detect polymorphisms of CYP1A1, CYP1A2, CYP1B1, ADH1B, EPHX1, EPHX2, NQO1, MPO, GSTP1 and UGT1A6 genes. Paper-13480350.
Initial AP neutrophil responses were significantly amplified compared with those in CP ( MPO, 3.2-fold; beta-NAH, 37.5-fold; CD, 2.2-fold; alpha-1-EPI, 1.4-fold; p < 0.05). Paper-9555993.
C-reactive protein stimulates myeloperoxidase release from polymorphonuclear cells and monocytes: implications for acute coronary syndromes. Paper-13594910.
By FACS, simvastatin decreased TNF-alpha-mediated ANCA antigen translocation (from 219 +/- 33 to 180 +/- 35 MFI for PR3 and 24.0 +/- 2.4 to 18.3 +/- 1.1 for MPO). Paper-9913020.
Immunohistochemical stains for CD4, CD34, CD56, CD68, CD117, CD123, TdT, lysozyme and myeloperoxidase were performed on 12 with available tissue blocks. Paper-12688823.
METHODS: PBMCs from vasculitis patients with PR3 ANCA or MPO ANCA and from healthy controls were stimulated for 7 days with PR3, MPO, or control stimuli. Paper-9513342.
The spontaneous membrane expression of MPO and PR3 on PMN could be significantly increased by lipopolysaccharide (LPS) and TNF-alpha, but not by IL-8 or GRO-alpha. Paper-12381438.
CONCLUSIONS: Our results suggest that polymorphism of CYP2E1, GSTP1, MPO and NQO1 genes does not contribute to overall NPC risk in a Han Chinese in southern China. Paper-15352369.
The granulocytes were positive for CD15, CD68, and myeloperoxidase on immunohistochemistry, and the megakaryocytes showed positive reactivity for factor VIII. Paper-10337236.
We investigated the stability of LF and MPO mRNA and the effects of purified recombinant human TNF-alpha on LF and MPO levels in normal human bone marrow. Paper-6902890.
Purified ceruloplasmin inhibited the peroxidase activity of MPO in a concentration-dependent manner, and exhibited selective binding to MPO-coated microtitre plates. Paper-980443.
In contrast, F(ab) binding to TPO was unaffected by human MPO (both native and reduced), bovine LPO, or human Tg at concentrations up to 10(-8) mol/L. Paper-198841.
Concentrations of alpha(1)-protease inhibitor (API), secretory leukocyte protease inhibitor ( SLPI), NE-API complex, and myeloperoxidase ( MPO) were measured by ELISA. Paper-2039256.
Myeloperoxidase deficiency is probably just another phenotypical marker of some patients with generalized ceroidlipofuscinosis rather than the genetic defect of Batten disease. Paper-2293525.
To confirm its role in recognition, it was shown that purified immobilised MPO binds SP-A and SP-D, and that MPO is surface-exposed on late apoptotic neutrophils. Paper-15575299.
These data indicate that BCM can enhance neutrophil- induced genotoxicity by inhibition of MPO in combination with subsequent increased formation of hydroxyl radicals. Paper-13636438.
We sought to examine whether MPO and other markers of inflammation are associated with MDD and whether the association is confounded by genetic or other shared familial factors. Paper-12975607.
Antineutrophil cytoplasmic antibodies against myeloperoxidase, proteinase 3, elastase, cathepsin G and lactoferrin in Japanese patients with rheumatoid arthritis. Paper-15674149.
Heating reduced histamine, MPO, and ECP concentrations significantly (p < 0.05) in nonfiltered whole blood, whereas PAI-1 concentrations increased significantly (p < 0.05). Paper-1243042.
There were significant increases (P<0.01) in expression of IL-8, MPO, IL-1beta, TREM, MMP9, and C5aR in circulating blood at 24 hours postoperatively, but not at six hours. Paper-10913293.
Here we show that peroxisome proliferator-activated receptor gamma ( PPARgamma) agonists strongly regulate MPO gene expression through the AluRRE. Paper-10205399.
Myeloperoxidase inactivates TIMP-1 by oxidizing its N-terminal cysteine residue: an oxidative mechanism for regulating proteolysis during inflammation. Paper-12534131.
Its consensus DNA binding site has been isolated, and sites in several promoters of myeloid-specific genes, such as CD34, lactoferrin, and myeloperoxidase, have been defined. Paper-501040.
RESULT: Combination of emodin and baicalein significantly reduced pancreatic TNF-alpha, IL-6 and MPO, and also inhibited pancreatic SDF-1 expression. Paper-13709414.
Demyelination in MS is associated with increased activity of MPO, suggesting that this production of reactive oxygen species may contribute to axonal injury within plaques. Paper-12998795.
As compared with the sputum of asthmatic subjects, the sputum of CF patients contained high concentrations of chloramines along with high levels of taurine and active MPO. Paper-437034.
GSTM1 deletion was quite common in both controls (49.4%) and cases (50.3%) but was not associated with risk of lung cancer alone or in combination with the MPO polymorphism. Paper-9500840.
MATERIAL AND METHODS: Blood samples from 298 patients hospitalized with a myocardial infarction were subsequently tested for NT-proBNP, hsCRP, MMP-9, PAPP-A, MPO, sCD40L and FM. Paper-13057793.
The hematopoietic foci included erythroid precursors, myeloid precursors, and megakaryocytes, which were immunoreactive with hemoglobin, myeloperoxidase, and CD61, respectively. Paper-12682590.
RESULTS: CRP treatment significantly increased release of MPO (both mass and activity) from human PMNs as well as monocytes ( P < 0.05) and caused NO(2)-Tyr of LDL. Paper-13594910.
We introduced the NQO1 gene into the HL-60 cell line to create a high MPO-, high NQO1-expressing cell line, and tested its response in assays of benzene metabolite toxicity. Paper-1931528.
Fecal lactoferrin, myeloperoxidase and serum C-reactive are effective biomarkers in the assessment of disease activity and severity in patients with idiopathic ulcerative colitis. Paper-14637070.
Neutrophil infiltration was assessed using the myeloperoxidase ( MPO) assay and immunohistochemical staining for CD43-positive ( CD43+) cells. Paper-8947991.
When cytochemical detection of MPO was coupled with immunologic detection of LF, LF was observed in the population of MPO-negative granules, which were identified as specific. Paper-4884486.
The presence of 0.1 N Cl- or Br- shifted the pH optimum for MPO to about 5.4 but had little or no effect on TPO- or LPO-catalyzed iodination. Paper-7523342.
Antibodies against myeloperoxidase ( MPO) and proteinase 3 ( PR3) are the predominant autoantibodies present in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Paper-8533602.
CONCLUSIONS: This pilot Singapore study concludes that there is no significant ANCA association with proteinase 3, lactoferrin, myeloperoxidase, elastase, cathepsin G and lysozyme. Paper-8751679.
The importance of apolipoprotein E ( ApoE) and myeloperoxidase ( MPO) genotypes in the clinical characteristics of multiple sclerosis ( MS) has been recently emphasized. Paper-10439177.
The presence of each marrow-derived lineage, dysplasia and immunohistochemical results were evaluated ( CD34, CD117, myeloperoxidase, CD68, p53, TdT, CD42b and hemoglobin). Paper-11266254.
Genetic ( knockout mice) or pharmacological (1400W and L-NAME) inhibition of iNOS activity reduced indomethacin induced gastric damage, despite no reduction in MPO activity. Paper-10288914.
The intraneutrophilic concentrations of lactoferrin, myeloperoxidase, collagenase and chymotrypsin-like cationic proteins were measured sequentially during acute bacterial infection. Paper-3132399.
It is shown here that perlecan binds myeloperoxidase via its heparan sulfate side chains and that this enhances oxidative damage by myeloperoxidase-derived HOCl and HOBr. Paper-14166669.
Immunoreactivities of CD3, CD163, myeloperoxidase, TNF-α, IL-8, IL-17, MMP-2, MMP-9 and VEGF were significantly higher in both PG and Sweet's syndrome than in controls (P=0·0001). Paper-15399258.
Three of the patients with anti- LF antibodies had vasculitis affecting areas additional to the pulmonary-renal involvement which characterised the patients with anti- MPO antibodies. Paper-7652939.
Eosinophil peroxidase ( EPX) is one of a family of mammalian peroxidases that includes myeloperoxidase ( MPO), lactoperoxidase ( LPO), and thyroid peroxidase ( TPO). Paper-8447112.
Two c-myb antisense oligomers of identical length with either 2- or 4-bp mismatches had no effect on cell growth nor did an 18-bp c-myb sense or myeloperoxidase antisense oligomer. Paper-6475644.
Polymorphisms in genes involved in oxidative stress-related mechanisms ( GSTA1, GSTM1, GSTT1, GSTP1, MPO, MnSOD, eNOS, CAT) were determined from blood samples by MALDI-TOF. Paper-12709952.
The antibody 7D5, secreted by the hybridoma, bound to solubilized cytochrome b of the neutrophils but not to other proteins such as hemoglobin, myeloperoxidase, and pig cytochrome P-450. Paper-5503683.
In humans with established cardiovascular disease, myeloperoxidase ( MPO) oxidizes HDL, and oxidation by MPO impairs apoA-I's ability to activate LCAT in vitro. Paper-12920463.
Myeloperoxidase impairs ABCA1-dependent cholesterol efflux through methionine oxidation and site-specific tyrosine chlorination of apolipoprotein A-I. Paper-11310334.
Among the patients, GSTM1 null was associated with a significant increase of CA and MPO AA was associated with a significant decrease of CA compared to their respective wild-type genotypes. Paper-10073260.
We investigated a functional biallelic (G/A) polymorphism in the promoter region (-463) of the MPO gene in 465 patients affected by MS, divided into 204 cognitively normal and 261 impaired. Paper-11383980.
MMP-8 levels correlated significantly with the small airway flow parameters (MEF50, MEF25) (p = 0.005 and p = 0.0004) and markers of neutrophil activation ( myeloperoxidase, lactoferrin). Paper-13447481.
The released amounts of eosinophil cationic protein ( ECP), eosinophil protein X (EPX), myeloperoxidase ( MPO), and lactoferrin ( LF) were measured by radioimmunoassay (RIA). Paper-7628016.
After IR (60 minutes each) we determined wet-to-dry weight ratio, and levels of ET-1, neutrophil elastase ( NE), myeloperoxidase ( MPO), and malondialdehyde ( MDA). Paper-14769280.
Diagnostic value of MPO and lysozyme antibodies in acute leukemia. Implications for the definition of FAB subtypes using a flow cytometric approach in combination with different permeabilising methods. Paper-1764632.
Immunohistochemical study demonstrated that the expression levels of TNF-alpha, ICAM-1, and MPO were all increased in the SAH group, but these increases were attenuated in the PDTC group. Paper-13400338.
Immunogold cytochemistry on LR White resin sections localised elastase and myeloperoxidase to the primary granules, lactoferrin to the secondary granules and lysozyme to both types of granule. Paper-6448649.
The blasts in this group were non-reactive for myeloperoxidase or non-specific esterase and expressed CD7, CD34 and CD36 with variable expression of CD61, CD13 and CD33. Paper-338557.
Immunohistochemical study was performed to assess the expression and localization of tumor necrosis factor (TNF)-alpha, intercellular adhesion molecule (ICAM)-1, and myeloperoxidase ( MPO). Paper-13400338.
RESULTS: During untreated phase of LJP myeloperoxidase, lysozyme and lactoferrin concentrations were remarkably elevated in peripheral blood PMNs, also reflected in their high concentrations in GCF. Paper-784410.
We investigated the relationship between DNA adduct levels and genetic polymorphisms in key enzymes of chemical carcinogenesis: CYP1A1, CYP1A2, GSTT1, GSTM1, GSTP1, NQO1 and MPO. Paper-9203271.
Moreover, significant associations with multiple SNPs in the phase II genes ALDH2, COMT, EPHX1, SOD2, NAT1, NAT2, GSTM3, GSTP1, GSTT2 and MPO were also found. Paper-12774741.
The expression of the myeloperoxidase ( MPO) gene is restricted to cells of the myeloid cell lineage and is induced by granulocyte colony-stimulating factor ( G-CSF). Paper-1156116.
Stimulation with PR3, and to a lesser extent with MPO, induced a Th2 cytokine milieu, characterized by high production of IL-6 and IL-10 and low production of IFN gamma in patients and controls. Paper-9513342.
Acid extracts of myeloperoxidase from either control or patient neutrophils also yielded chemiluminescence in the presence of streptococci, but not in the presence of catalase-positive microbes. Paper-3874343.
Studies focused on GSTT1 null and SOD2 Ala16Val polymorphisms gave conflicting results, while promising results came from studies on alpha1-antitrypsin in asbestosis and MPO in lung cancer. Paper-12893123.
Significantly greater areas of positive immunostaining for CD68, CD3, MCP-1, MMP-2, IL-17 and MPO were found in plaques from symptomatic patients compared with asymptomatic patients (p<0.05 for all). Paper-14119599.
A sequential pattern of first LF release followed by MPO and beta-glu was demonstrated with each of the stimuli examined, with or without cytochalasin B pretreatment. Paper-3550847.
Significant, albeit not large, correlations were found between subgingival temperature and NE ( r = 0.35, p < 0.001), MPO ( r = 0.26, p < 0.001) and BG ( r = 0.23, p < 0.01). Paper-1318662.
The observations presented led us to conclude that the administration of TCA at subchronic was decreased BChE and ADA activities whereas increased MPO activity in various tissues of rats. Paper-15451727.
Our findings suggest that MPO produces hypobromous acid as well as hypochlorous acid in the airways of children with CF and that these oxidants are involved in the early pathogenesis of CF. Paper-15420048.
Based on adjustment by age, gender and smoking history, the MPO GA interacted with the presence of GSTM1 and GSTT1 genotypes to significantly reduce the risk (OR = 0.17, 95% CI = 0.03-0.98). Paper-10073260.
There was weak risk reduction associated with GSTM1 null in heavy smokers (OR = 0.71; 95%CI 0.54-0.94; P = 0.02), but neither GSTM1 nor MPO genotypes affected the overall risk of NSCLC. Paper-10823008.
We investigated whether ALL outcome was related to polymorphisms in genes CYP2D6, MPO, EPHX1, NQO1, TS, XPD and XRCC1 in 95 consecutive ALL children by PCR or PCR-FRLP techniques. Paper-13752871.
Overexpression of ZNF342 by juxtaposition with MPO promoter/enhancer in the novel translocation t(17;19)(q23;q13.32) in pediatric acute myeloid leukemia and analysis of ZNF342 expression in leukemia. Paper-13714678.
SP-A nitration and oxidation by MPO is markedly enhanced in the presence of physiological concentrations of Cl - and the lipid aggregation function of SP-A is completely abolished. Paper-9590673.
CD11b neutrophil expression, and myeloperoxidase and lactoferrin production, were found to be upregulated during CPB and then to decline to preoperative levels by the third postoperative hour. Paper-8708705.
The AELJ (100 mg/kg) also significantly inhibited PAR2 agonists- induced myeloperoxidase ( MPO) activity and tumor necrosis factor (TNF)-alpha expression in paw tissue. Paper-9936108.
Collectively, these results reveal that binding of MPO to CD11b/ CD18 integrins stimulates PMN signaling pathways to induce PMN activation in a mechanism independent of MPO catalytic activity. Paper-11187971.
The murine glial fibrillary acid protein ( GFAP) gene is located on chromosome 11 in close proximity to the genes encoding transforming protein p53 (Trp53) and myeloperoxidase ( Mpo). Paper-42588.
Antibodies against MPO, PR-3, LF, CG and EL were determined in sera from 125 patients with RA and 83 sera from patients with other rheumatic diseases by enzyme-linked immunosorbent assay. Paper-15674149.
We measured plasma PTX3, serum hsCRP, lactate, noradrenaline (NOR), white blood cells (WBC), interleukin-6 ( IL-6) and myeloperoxidase ( MPO), a marker of neutrophil degranulation. Paper-15495728.
On day 10, colons were removed and assessed for pathological score, myeloperoxidase ( MPO), NO synthase ( NOS), TACE enzymatic activity and protein levels, colonic TNF-alpha and NOx- levels. Paper-9128722.
NO metabolites (NO(x)) and MPO levels in fresh sputum of control and adult CF patients were determined and related to measurements of eNO and to in vitro consumption of NO in CF sputum. Paper-14647849.
Peroxisome proliferator-activated receptor gamma ligands regulate myeloperoxidase expression in macrophages by an estrogen-dependent mechanism involving the -463GA promoter polymorphism. Paper-10205399.
After 2 weeks, significant reductions (p<0.05) in all serum lipids (except HDL cholesterol), 8-iso-PGF2alpha, MPO, sICAM-1, sE-selectin, CRP, MMP-9, and cellular MCP-1 production were noted. Paper-13113039.
Of importance, our in vitro studies found that MPO mediated oxidative inactivation of NE, an enzyme that has been widely implicated in the pathogenesis of various tissue-destructive diseases. Paper-10986726.
In AITD patients antibody binding to TPO could not be inhibited by adding native MPO to the serum diluent, suggesting that the possible cross-reactive epitopes were exposed in the denaturated MPO molecule. Paper-1106512.
Our results indicate that local production of markers of the nonspecific inflammatory response is high in both chronic and acute pleural infection, and suggest a role for IL-8 in the release of NE and MPO. Paper-1442986.
Furthermore, we tried to characterize the antigen specificity by enzyme-linked immunosorbent assay ( ELISA), using elastase, lactoferrin, myeloperoxidase, proteinase 3, and cathepsin G as antigens. Paper-389536.
Myeloperoxidase ( MPO), an enzyme derived from neutrophils, metabolically activates a wide range of carcinogens, whereas glutathione S-transferase M1 ( GSTM1) detoxifies various electrophilic metabolites. Paper-9500840.
The contact between CP and MPO probably entails conformational changes close to the p-phenylenediamine binding site in CP, which explains the observed activation by MPO of the substrate's oxidation. Paper-13503432.
To address heme identity for LPO, we used comparative magnetic circular dichroism (MCD) spectroscopy of LPO versus myoglobin ( Mb), horseradish peroxidase (HRP), and MPO. Paper-547643.
Analyses of bulky DNA adduct levels in human breast tissue and genetic polymorphisms of cytochromes P450 (CYPs), myeloperoxidase ( MPO), quinone oxidoreductase ( NQO1), and glutathione S-transferases (GSTs). Paper-9203271.
Amino acids recognized by TPOAbs are located in the regions with homology to myeloperoxidase ( MPO) and the complement control protein (CCP) but not in the epidermal growth factor (EGF)-like region. Paper-12540120.
The perfusion fluid concentrations of bFGF, biochemical markers of inflammation, myeloperoxidase ( MPO), interleukin-6 ( IL-6), and permeability (albumin) were determined with immunochemical methods. Paper-8429167.
In GER children, but not in controls, neutrophil proportion significantly correlated with LLM index (r=0.65, P=0.002), with IL-8 (r=0.62, P=0.003) and MPO levels (r=0.54, P=0.014) but not with elastase concentrations. Paper-11334278.
Colonic damage score, tissue myeloperoxidase ( MPO) activity, TLR4, NF-kappaB mRNA expression, and tissue TNF-alpha, TLR4, NF-kappaB production were determined, respectively. Paper-13649189.
Polymorphisms of the GSTM1, GSTP1, MPO, XRCC1, and NQO1 genes in Chinese patients with non-small cell lung cancers: relationship with aberrant promoter methylation of the CDKN2A and RARB genes. Paper-10751323.
Because a single methionine residue in apoA-I, Met-148, resides near the center of the protein's LCAT activation domain, we determined whether its oxidation by MPO could account for the loss of LCAT activity. Paper-12920463.
AMPD3 mRNA, AMPD activity and IMP production in the lungs significantly increased after ischemia-reperfusion with increases in MPO activity, TNF-alpha level and decreased oxygen saturation (SpO(2)). Paper-12469672.
In the present study, we show that activation of the neutrophil respiratory burst by anti- PR3 and anti- MPO is strongly enhanced after TNF priming and lost on removal of the Fc parts of the antibodies. Paper-389256.
We found that activated neutrophils lost cathepsin G activity by a pathway requiring myeloperoxidase, suggesting that oxidants generated by myeloperoxidase might regulate cathepsin G activity in vivo. Paper-11035949.
Associations between deletion genotypes of GSTM1 and GSTT1 and between single nucleotide polymorphisms ( SNPs) of GSTP1 Ile105Val and MPO G-463A were first tested by adjusted logistic regression. Paper-10823008.
The 5-year incidence of HCC was 34.4% in patients with both the GG- MPO genotype and one or two Ala- SOD2 alleles, 5.1% in patients with only one of these two traits, and 0% in patients with none of these traits. Paper-14167771.
However, the pathways that promote the chlorination of specific Tyr residues in apoA-I are controversial, and the mechanism for MPO- mediated loss of ABCA1-dependent cholesterol efflux of apoA-I is unclear. Paper-11310334.
CONCLUSIONS: The sputum processing by DTT caused a statistically significant fall in EPO and MPO concentrations but did not significantly influence the measured concentrations of ECP and EPX. Paper-8800141.
Consequently, our data suggest that TPO autoantibodies that cross-react with MPO, LPO, or Tg, or inhibit TPO enzymatic activity are likely to bind outside the immunodominant region. Paper-198841.
RESULTS: Individuals with periodontal disease exhibited a significant increase in the activities of MPO, GPx, GST, and also in TBARS and GSSG levels in gingival tissue compared to the control group (P<.05). Paper-13454560.
To date, the role of neither soluble mediators, such as cytokines, nor serum levels of myeloperoxidase ( MPO), eosinophil cationic protein ( ECP) and tryptase (TRY) have been studied in the peripheral blood of DH. Paper-9210698.
RESULTS: The MPO levels were significantly higher in case subjects than in control subjects and correlated with C-reactive protein ( CRP) (rho = 0.25; p < 0.001) and white blood cell count (rho = 0.33; p < 0.001). Paper-13304079.
RESULTS: The incidence of antibodies directed against alphaGr and HLE but not PR3, MPO, LF or BPI was increased in the PiZZ as compared to the PiMM group (Fisher probability respectively P < 0.0001 and P < 0.05). Paper-8761790.
A case-control study was conducted to investigate the effects of genetic polymorphisms in the MPO, EPHX1, GSTT1, GSTM1, GSTP1 and NQO1 genes on the risk of early-onset lung cancer development. Paper-15160143.
Explaining the differences in clinical presentation between proteinase 3 (PR3)- associated AAV and myeloperoxidase (MPO)-associated AAV requires an adequate animal model for PR3-ANCA disease, which is currently lacking. Paper-15873596.
RESULTS: Treatment of NaB, 5-ASA, and the combination improved diarrhoea, colonic damage score, and MPO activities, increased TFF3 mRNA expression, and decreased serum IL1beta production and tissue NFkappaB expression. Paper-10810587.
However, adhesion to myeloperoxidase was inhibited by monoclonal antibodies to alpha M ( CD11b) or to beta2 ( CD18) integrin subunits, but not by antibodies to alpha L (CD11a), alpha M (CD11c), or to other integrins. Paper-1079765.
Expression of FLT3/ITD completely blocked morphologic differentiation and induction of myeloperoxidase ( MPO), lysozyme, and CCAAT/enhancer-binding protein epsilon (C/EBPepsilon) in response to G-CSF. Paper-9276079.
Studying separately the NGS-2 subpopulation with the CD16/ MPO/LF combination, the low CD16(+)/MPO(+) and low CD16(+)/LF(+) percentages seemed to discriminate between lower-risk and higher-risk patients with MDS in most occasions. Paper-13703889.
Catalase (CAT), Glutathione peroxidase ( GSHPx), Myeloperoxidase ( MPO) activities and the levels of Malondialdehyde ( MDA) were measured in whole blood, serum and synovial fluid in both groups. Paper-15686333.
The effects of genetic polymorphisms in the NQO1 (rs1800566), MPO (rs2333227), and XRCC1 (rs25487) genes on benzene-induced chromosome abnormalities were assessed in 108 benzene-exposed workers and 33 office workers. Paper-12705767.
Our findings indicate that the level of MPO gene expression influences the CF pathogenesis, presumably reflecting cellular damage by MPO-generated oxidants or other activity of MPO in airway inflammation. Paper-12162053.
Biochemical assays of 12 substances (hemoglobin, albumin, transferrin, alpha(1)-antitrypsin, fibronectin, IgA, IgG, IgM, lactoferrin, myeloperoxidase and neutrophil elastase) were conducted at a commercial laboratory. Paper-11067885.
Rapid kinetic measurements indicate that MPO, EPO, and LPO Compound I formation occur at rates slower than complex decay, and its formation serves to simultaneously catalyze SCN- via 1e- and 2e- oxidation pathways. Paper-11135177.
RESULTS: The increases of TM, vW, sVCAM-1, CRP, SOD and Mpx correlated with the CAD status in the order CO < SAP < ACS, whereas NO and sL-selectin were inversely correlated (p < 0.05, resp.). The other markers remained unchanged. Paper-12250371.
Exceptionally, serum-opsonized A. actinomycetemcomitans stimulated myeloperoxidase isoform release in proportion to the neutrophil granule constituency with or without localized juvenile periodontitis serum pre-opsonization. Paper-992543.
Effect of tumor necrosis factor-induced integrin activation on Fc gamma receptor II-mediated signal transduction: relevance for activation of neutrophils by anti- proteinase 3 or anti- myeloperoxidase antibodies. Paper-389256.
A questionnaire was used to determine relevant demographic and lifestyle characteristics, and polymorphisms in following genotypes were determined GSTM1, GSTM3, GSTP1, GSTT1, GPX1, MPO, NQO1 and NAT2. Paper-11178082.
In this investigation, we studied 120 AR patients and 90 matched controls to elucidate the association between polymorphisms in some metabolizing genes ( GSTM1, GSTT1, CYP2E1, mEH, PON1, and MPO) and susceptibility to AR. Paper-9196437.
CONCLUSIONS: As opposed to never smokers, those with acute cigarette smoke exposure (< or =6h) had significantly higher concentrations of all markers (p<0.0001) except serum CD40L, MPO, and TNFR2; plasma CD40L were significantly lower. Paper-12768166.
In contrast, both groups showed significant activation of neutrophils, platelets and coagulation, as indicated by an early increase in myeloperoxidase and a post-operative increase in beta-thromboglobulin and F1 + 2, respectively. Paper-13440249.
In this study we have extended the investigations on neutrophil activation by ANCA directed against proteinase 3 ( PR3), myeloperoxidase ( MPO) and lactoferrin ( LF), and we have analysed the underlying mechanisms. Paper-138687.
3. The following humoral markers of the inflammatory response to exercise were measured: polymorphonuclear myeloperoxidase ( MPO), anaphylatoxin C5a (C5a), tumour necrosis factor-alpha ( TNF-alpha) and interleukin-6 ( IL-6). Paper-1029979.
Treatment with an NO donor, both with and without associated hemorrhage, reduced the inflammatory response at the systemic ( TNF-alpha and IL-10) and kidney ( MPO, SOA, and SOD) levels, normalizing kidney function. Paper-11278913.
In addition, RvD1 markedly reduced LPS-induced the expression of cyclooxygenase-2 ( COX-2), inducible nitric oxide synthase ( iNOS), and adhesion molecules, as well as myeloperoxidase ( MPO) activity. Paper-15933155.
RESULTS: With a median follow-up of 4.3 years, patients with AML blasts negative for CD9, CD11b, CD13, CD34, and CD41, or positive for CD15, CD33, CD38, CD64, and MPO had superior overall survival. Paper-10020494.
Our results indicate that chlorination of apoA-I by the MPO pathway selectively inhibits two critical early events in cholesterol efflux: (1) the binding of apoA-I to ABCA1 and (2) the activation of a key signaling pathway. Paper-15156914.
The expressions of CD11b/ CD18, ICAM-1 and MPO in T/ HS + RL group were significantly increased compared to T/SS group ( P = 0.025, P = 0.036, P = 0.028, respectively). Paper-12317257.
We examined the associations between NOS3 Glu298Asp and MPO G-463A polymorphisms and breast cancer risk by cigarette smoking among post-menopausal women in the American Cancer Society's Cancer Prevention Study II Nutrition Cohort. Paper-13270801.
A systemic bolus (i.v.) of aFGF (2.6 microg) administered immediately after myocardial ischemia, significantly reduced (p<0.001) the MPO activity in the ischemic reperfused left ventricle compared to vehicle-treated rats. Paper-1016895.
I/ R produced a significant increase in the superoxide dismutase (SOD), xanthine oxidase (XO), adenosine deaminase ( ADA) and myeloperoxidase ( MPO) activities in spinal cord tissue when compared with control group. Paper-10855876.
The observations presented led us to conclude that the administrations of IBA at subacute and subchronic exposure decreased AChE, BChE and ADA activities whereas increased MPO activity in various tissues of rats. Paper-13773243.
On the other hand, neither granulocyte/macrophage colony-stimulating factor ( GM-CSF) nor IL-3 induced MPO gene expression, but they inhibited G-CSFR-mediated MPO gene expression. Paper-101786.
There were significant differences (P<0.01) between preoperative specimens and normal comparisons (i.e. higher MPO, PDGF, TREM and IRAKM; lower mtHSP) reflecting the effects of chronic inflammation associated with osteoarthritis. Paper-10913293.
Potential cross-reactivity between thyroid peroxidase ( TPO) and myeloperoxidase ( MPO) molecules was evaluated by analysing the binding of 199 TPO antibody- and MPO antibody-positive sera to TPO and MPO molecules. Paper-1106512.
Serum levels of amylase, tumor necrosis factor alpha ( TNF-alpha), interleukin 1beta (IL-1beta), and interleukin 10 ( IL-10) as well as myeloperoxidase ( MPO) activity in pancreatic tissue were determined. Paper-14209697.
Our findings demonstrate the formation of MPO-derived oxidizing and possibly nitrating species within the respiratory tract of subjects with CF, which collectively may contribute to bronchial injury and respiratory failure in CF. Paper-8424857.
Here we show that chlorination (but not nitration) of apoA-I by the MPO pathway impairs its ability to interact directly with ABCA1, to activate the Janus kinase 2 signaling pathway, and to promote efflux of cellular cholesterol. Paper-15156914.
Expression of CD3, CD10, CD15, CD20, CD34, CD61, CD68, CD79a, CD99, CD117, CD138, myeloperoxidase, haemoglobin A1, glycophorin and terminal deoxynucleotidyl transferase was immunohistochemically analysed. Paper-12400967.
In conclusion, the present data indicate that TPO autoantibodies can interact with TPO molecules in which the amino-terminus is replaced with the homologous MPO prosequence region, not normally present in mature MPO. Paper-7631103.
The use of immunogold double-labeling of CD67 and lactoferrin ( LF; as marker for specific granules) or CD67 and myeloperoxidase ( MPO; as marker for azurophilic granules) showed that CD67 occurred only in the specific granules. Paper-6922886.
Interestingly, AML1- MTG8 enhanced the expression of several genes that are usually induced during granulocytic differentiation, particularly those encoding azurophil granule proteins, including cathepsin G, myeloperoxidase and lysozyme. Paper-9448179.
Granulocyte-mediated reactions such as opsonization, chemotaxis, and release of granulocyte myeloperoxidase and lactoferrin were studied in properdin-deficient and normal human serum incubated with serogroup A and W-135 meningococci. Paper-7016644.
The gene polymorphisms of myeloperoxidase ( MPO), interleukin (IL)-1beta, IL-6, C-reactive protein ( CRP), fetuin A, and homocysteine and their gene product concentrations were correlated with 12-month kidney transplant function. Paper-14071695.
Vein graft extracts were analyzed for MMPs, TIMP-2, tumor necrosis factor-alpha ( TNF-alpha), polymorphonuclear neutrophil (PMN) infiltration, myeloperoxidase ( MPO), and thrombin activity, and for ERK-1/2 activation. Paper-11327903.
The cell specificity of monoclonal antibodies against eosinophil peroxidase ( EPO), eosinophil cationic protein ( ECP), human neutrophil lipocalin (HNL), and myeloperoxidase ( MPO) was investigated using immunocytochemical techniques. Paper-9444543.
Cardiac expression of endothelial selectin ( E-selectin) was decreased, whereas immunoreactivity to ED-1 and myeloperoxidase ( MPO) activity, markers of macrophage and leukocyte infiltration, respectively, were increased in DOCA-salt. Paper-10334356.
In contrast, both myeloperoxidase (MPO)-dependent oxygenation activity (measured by luminol luminescence) and chloramine release were increased significantly in both CF homozygotes and heterozygotes as compared with controls. Paper-756035.
METHODS: We tested a population of 191 PiZZ (273 sera) for ANCA activity versus 272 PiMM matched control subjects using alphaGr or antigen-specific ELISA [ PR3, HLE, MPO, lactoferin (LF) and bactericidal/ permeability increasing protein (BPI)]. Paper-8761790.
Lung tissues were harvested for myeloperoxidase ( MPO) determination, ICAM-1, VCAM-1, CXCR2, KC, MIP-2, interleukin-1beta, and interleukin-6 messenger RNA expression; iNOS immunohistochemical staining; and histologic studies. Paper-10566322.
The release of lactoferrin and HNL, but not of myeloperoxidase ( MPO), was slightly enhanced after preincubation of isolated normal neutrophils with G-CSF in vitro, but no obvious release of these proteins was observed with G-CSF alone. Paper-568924.
TNF-alpha-primed neutrophils were stimulated with monoclonal antibodies (MAb) to human myeloperoxidase ( MPO) and proteinase 3 ( PR3), and with preparations of human ANCA (three patients with PR3-ANCA and two patients with MPO-ANCA). Paper-8774777.
Our objective was to investigate the correlation between lipoprotein-associated phospholipase A2 (PLA2-LDL), myeloperoxidase ( MPO), and paraoxonase ( PON), enzymes implicated in the evolution of endothelial dysfunction associated with type 2 diabetes. Paper-10566204.
Particularly, genetic polymorphisms in NAD(P)H-quinone oxidoreductase ( NQO1), cytochrome P450 (CYP)1A1, myeloperoxidase ( MPO), glutathione-S-transferase (GST)P1, GSTT1, and GSTM1, and have been suspected to affect lung cancer risk. Paper-13339475.
We conclude that (a) an immunohistochemical panel including CD20, CD43, CD68, and MPO can successfully identify the vast majority (96%) of EMT in paraffin sections, and (b) there is an association between morphology and phenotype in these lesions. Paper-7665972.
ANCAs directed against either myeloperoxidase ( MPO) or proteinase 3 ( PR3) can activate cytokine-primed neutrophils by binding cell surface- expressed MPO or PR3, with the concurrent engagement of Fcgamma receptors (FcgammaR). Paper-8855251.
Genetic variations in catalase (CAT) (C-262T), myeloperoxidase ( MPO) (G-463A), endothelial nitric oxide synthase ( NOS3) (G894T) and heme oxygenase-1 ( HO-1) [(GT)(n) dinucleotide length polymorphism] were not associated with breast cancer risk. Paper-13745098.
Anti- myeloperoxidase antibodies enhance phagocytosis, IL-8 production, and glucose uptake of polymorphonuclear neutrophils rather than anti- proteinase 3 antibodies leading to activation-induced cell death of the neutrophils. Paper-12381438.
When compared to controls, plasma MDA, Cp, Cu levels and also plasma MPO activity were significantly higher in patients, whereas plasma TF, SH and Se levels, and also plasma GSH-Px activity were lower in BD patients than those in controls. Paper-491437.
CONCLUSION: The conceivable cumulative non-specific membrane effect of carvedilol and its effect on PLD signalling pathway contribute to the decrease of both superoxide generation and MPO release, thus supporting the restoration of NO-superoxide balance. Paper-12365987.
Vascular peroxidase 1 ( VPO1) is a newly discovered member of the peroxidase family that is mainly expressed in vascular endothelial cells and smooth muscle cells and has structural characteristics and biological activity similar to those of MPO. Paper-16218065.
The genetic contribution to the development of ALL is examined by association studies that analyze the loci of Phase I enzymes ( cytochrome P-450, myeloperoxidase) and Phase II enzymes ( quinone-oxidoreductase, glutathione-S-transferase, N-acetyltransferase). Paper-11556338.
Using cytochemical techniques the authors observed the intracellular deficiency of N-acetyl-beta-glucosaminidase accompanied by diminished absolute count of the enzyme-positive cells as well as the beta-glucuronidase- and the myeloperoxidase-positive neutrophils. Paper-3557238.
In this review, we highlight recent results on several of the more promising markers of inflammation for cardiovascular disease risk assessments, such as C-reactive protein, myeloperoxidase, and soluble CD40 ligand and nitrotyrosine, as well as other potential markers. Paper-10357722.
We determined whether episodes of a high CRP value were paralleled by simultaneous increases in mediators of inflammatory injury or molecules associated with endothelial cell adhesion or growth and whether CRP levels correlated with those of VEGF and MPO. Paper-12366540.
The effects of this exposure were evaluated using a questionnaire, spirometry and measurements of airway responsiveness ( methacholine) and levels of eosinophil cationic protein ( ECP), myeloperoxidase ( MPO), and C-reactive protein ( CRP) in serum. Paper-1957821.
Hepatic neutrophil influx, as assessed by myeloperoxidase ( MPO) levels, serum alanine aminotransferase (ALT), and hepatic TNF and ENA-78 levels, as measured by ELISA, were evaluated at 1, 6, and 12 h following operation. Paper-900185.
We investigated the potential role of the co-substrate, thiocyanate ( SCN-), in modulating the catalytic activity of myeloperoxidase ( MPO) and other members of the mammalian peroxidase superfamily ( lactoperoxidase ( LPO) and eosinophil peroxidase ( EPO)). Paper-11135177.
Specifically, the ability of this fraction to inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumor promotion and two markers of promotion in mouse skin, ornithine decarboxylase ( ODC) and myeloperoxidase ( MPO) activities, was evaluated. Paper-1772731.
Sera were tested by indirect immunofluorescence (IIF) and by ELISA for antibodies to neutrophil cytoplasmic components proteinase 3 ( PR3), myeloperoxidase ( MPO), cathepsin G ( CG), human leucocyte elastase (HLE), and lactoferrin ( LF). Paper-1212858.
Compared to baseline, significantly elevated concentrations of total protein, bradykinin, IL-1beta, TNF-alpha, IL-6, IL-8, MCP-1, IFN-gamma, MPO and sICAM-1 were detected in nasal lavage fluids of symptomatic patients, whereas IL-1ra remained unaltered. Paper-9142918.
The activities of catalase (CAT), prolidase ( PRS), myeloperoxidase ( MPO), total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), total thiol (T-SH) were determined in plasma and colon samples. Paper-14160116.
Biosynthetically radiolabeled CRT (60 kDa) and apopro- MPO (90 kDa) were coprecipitated from PLB 985 cells by monospecific antiserum against CRT when the immunoprecipitations were performed either under nondenaturing conditions or following reversible crosslinking. Paper-174084.
Cortical demyelination in MS is associated with increased activity of MPO, which is expressed by a CD68-positive subset of activated microglia, suggesting that microglial production of reactive oxygen species is likely to be involved in cortical demyelination. Paper-12709640.
CONCLUSION: The combination of the GG- MPO genotype (leading to high MPO expression) and at least one Ala- SOD2 allele ( associated with high liver iron score) markedly increased the risks of HCC occurrence and death in patients with alcoholic cirrhosis. Paper-14167771.
At the same time, FG alone, unlike recombinant GH alone, led to significant increases in anastomotic bursting pressures, tensile strength, and tissue HP content, along with decreases in anastomotic MPO and NF-kappaB activity and later plasma levels of TNF-a and IL-6. Paper-13618579.
Serum beta2M level was positively correlated with hCRP, interleukin-6 ( IL-6), tumor necrosis factor-alpha ( TNF-alpha), MPO, TnT, N-terminal pro-B-type natriuretic peptide (NT-proBNP) and inversely correlated with PA and ankle-brachial index (ABI). Paper-15197933.
RESULTS: Median serum concentrations of IL-6, SAA, ICAM-1, E-selectin, TNFalpha, and MPO and peripheral blood neutrophil count were higher in patients with RA than controls (all P < 0.05), independent of Framingham risk score and diabetes mellitus (DM). Paper-14092461.
All FAB M6 and M7 and trilineal leukaemias expressed mRNAs for alpha-globin, glycoprotein IIb (GpIIb), erythropoietin receptor ( Epo-R) and thrombopoietin receptor (c-mpl), but not for myeloperoxidase ( MPO) which in contrast was expressed in the other FAB-subtype leukaemias. Paper-1616026.
Cotreatment with an inhibitor of IL-1beta and TNF-alpha synthesis, pentoxifylline, decreased stilbene estrogen-induced levels of myeloperoxidase ( MPO), 8-hydroxydeoxyguanosine formation, and gene mutations, and prevented stilbene estrogen-induced lesions. Paper-13304391.
After biopsy, conventional immunohistochemical stains were positive for CD45 (hematological marker) and myeloid markers, such as myeloperoxidase, and CD68, demonstrating a myeloid lineage with monocytic cell differentiation, suggesting the diagnosis of GS associated to AML-M5. Paper-13746389.
Neutrophils and myeloperoxidase ( MPO) colocalized with SP-D in a murine bacterial pneumonia model of acute inflammation, suggesting that MPO-derived reactive species might alter the function of SP-D. Paper-15125474.
MPO in plasma from 246 blood samples (103 used for statistical analysis) from 27 patients (18 LTX and 9 HTX) was determined using ELISA; C-reactive protein ( CRP), gamma-glutamyl-transpeptidase ( GGT), white blood count and CMV pp65 antigen were monitored routinely. Paper-13552247.
Upon omission of TGF-beta1, percentages of CD1a+ DC decreased (to mean, 10% +/- 8%; P = .001) and, in turn, percentages of granulomonocytic cells (CD1a- cells that are lysozyme [ LZ+]; myeloperoxidase [ MPO+]; CD14+) increased approximately threefold ( P < .05). Paper-1145872.
In this study, the main antioxidant enzymes (AOE) of glutathione peroxidase ( GPX), superoxide dismutase (SOD), catalase (CAT) and myeloperoxidase ( MPO) were identified, and the influence of sex and age in healthy human polymorphonuclear leukocytes (PMNL) was determined. Paper-9850195.
OBJECTIVES: To investigate the roles of insulin-like growth factor II ( IGF2), myeloperoxidase ( MPO), E-cadherin ( CDH1), urokinase and xeroderma pigmentosum group A and D ( XPA, XPD) polymorphisms upon leiomyoma susceptibility. Paper-15285896.
Myeloperoxidase ( neutrophil marker), IL-8 (cytokine chemotactic for neutrophils) and MMP-9 (proteinase-mediating tissue damage) were expressed more significantly in both ulcerative and bullous PG than in vegetative PG as well as in Sweet's syndrome (P=0·008-P=0·0001). Paper-15399258.
In addition, compared with the control group, SFN markedly reduced liver tissue MPO activity (P < 0.05) and elevated liver tissue GSH and GSH-Px activity (P < 0.05, P < 0.05), which was in parallel with the increased level of liver Nrf2 and HO-1 expression. Paper-15262195.
In addition, we investigated whether interaction of PR3 or MPO with HUVEC monolayers also resulted in antibody-dependent cell- mediated cytotoxicity ( ADCC) mediated by anti-neutrophil cytoplasmic antibody (ANCA)-positive patient sera or rabbit IgG anti- PR3 or anti- MPO. Paper-8049921.
NO synthase inhibitors, L-NAME and aminoguanidine, as well as the neurotoxin capsaicin and NK1, calcitonin gene-related peptide ( CGRP) receptor antagonists, SR140333 and CGRP(8-37), prevented SLIGRL-induced MPO and damage score increases and permeability. Paper-9754569.
RESULTS: Positive-stained cells of CD15 ( CD15) and MPO ( MPO+) were mainly located in glomeruli with cellular crescents and segmental fibrinoid necrotic lesions and in periglomerular area of cellular crescents, especially at the area of ruptured Bowman capsule. Paper-15529469.
Analysis of the DNA methylation status at key sites within these genes showed a pattern of differentiation- and expression-associated demethylation of the LZM gene, which was also enhanced by G-CSF, and constitutive and unaltered demethylation at key regions of the CD34 and MPO genes. Paper-475933.
The T-cell clones shared TCR Beta CDR3 amino acid motifs, depending on their MPO epitope: AGXiXiN was used by clones recognizing the light chain and TGXiS or QGXiE by those recognizing the heavy chain, whether the cells were derived from MPA patients or healthy subjects. Paper-14574653.
This in vitro study, therefore, attempted to investigate whether different biomaterials influence monocyte cellular activity, determined by the myeloperoxidase level and mitochondrial XTT cleavage, and phenotype dynamics characterized by the presence of CD14, RM 3/1 and 27E10 antigens. Paper-11783493.
The effect of daily in vivo granulocyte colony-stimulating factor ( G-CSF) treatment on neutrophil function was studied over a 14-day period using a luminescence system for differential measurement of oxidase and myeloperoxidase ( MPO) dioxygenation activities in whole blood. Paper-1005201.
We examined the association between malignant lymphoma risk and the polymorphisms of the IL-1 gene family [ IL-1B -31 C/ T, IL-1A -889 C/ T, and IL-1RN 86-bp variable number of terminal repeat ( VNTR)] and myeloperoxidase ( MPO -463 G/A). Paper-9106149.
Among the AQP4 + / MS patients, a significant positive correlation between anti- HP-NAP antibody levels and the final Kurtzke's Expanded Disability Status Scale scores was found, and MPO levels were higher in anti- HP-NAP antibody-positive patients than anti- HP-NAP antibody-negative ones. Paper-14617532.
ALA significantly inhibited the ability of CAR to induce: (1) the degree of acute inflammation, (2) the rise in MPx activity, (3) the increases of GST and iNOS activities and the amount of LPO and (4) the decreases of GPx, GR and SOD activities and the amount of GSH. Paper-15604361.
Based on recent observations with several anti-inflammatory and thiol-containing drugs, the present study was designed to test the hypothesis that anti-hypertensive agents from the angiotensin converting enzyme (ACE) inhibitors group inhibit the oxidative modifications of Apo B-100 caused by MPO. Paper-11846847.
METHODS: We measured mucosal myeloperoxidase ( MPO) activity as a marker of inflammation, plasma CRH level, and abdominal withdrawal reflex (AWR) to colorectal distension as a visceral nociceptive response at 2, 7 and 14 d after the induction of colitis with 4% acetic acid. Paper-12700342.
The myocardial infarct volume, serum levels of Tn-T, TNF-alpha and IL-6, content of MDA and MPO activity in myocardial tissue were all reduced, protein expression of HMGB1, phosphor-I kappaB-alpha and phosphor- NF-kappaB were down-regulated, while attenuated the decrease of SOD and GPx activities. Paper-14624718.
Thirteen single nucleotide polymorphisms ( SNPs) from 10 oxidative stress genes ( AKR1A1, AKR1C1, CYBA, GPX, MPO, NOS2A, NOS3, OGG1, PPARG and SOD2) were genotyped in 1172 NHL cases and 982 population-based controls from a USA multicenter case-control study. Paper-12180974.
METHODS: Our study included 5 patients, 4 patients with myeloperoxidase (MPO)-ANCA- associated renal vasculitis and 1 patient with proteinase 3 (PR3)-ANCA-associated renal vasculitis, who had achieved remission through treatment with methylprednisolone pulse therapy, corticosteroids, and CYC. Paper-10432501.
A 30% release of myeloperoxidase ( MPO) and lactoferrin ( LF) from the primary and specific granules, respectively, was detected by enzyme-linked immunosorbent assay in adhered neutrophils stimulated with 0.1 microM N-formyl-methionyl-leucyl-phenylalanine ( FMLP) or 20 microM A-23187. Paper-7727719.
We studied -308G>A TNF-alpha, +252A>G TNF-beta, -174G>C IL-6, -1082A>G IL-10, +125C>G PECAM-1, and the -463A>G MPO inflammatory gene polymorphisms in 80 osteosarcoma patients and 160 control individuals using polymerase chain reaction-restriction-fragment length polymorphism method. Paper-13223587.
Serial nasal lavage samples were analyzed for the presence of inflammatory cells ( eosinophils and neutrophils) and soluble markers associated with cellular inflammation [ interleukin-5 ( IL-5), interleukin-8 ( IL-8), eosinophil cationic protein ( ECP) and myeloperoxidase ( MPO)]. Paper-9696434.
PURPOSE: Because radiotherapy exerts cytotoxic effects via generation of massive oxidative stress, we hypothesized that catalase, manganese superoxide dismutase, myeloperoxidase ( MPO), and endothelial nitric oxide synthase ( eNOS) genotypes might result in greater risk of radiotoxicity. Paper-12344994.
The main purpose of the present study was to evaluate myeloperoxidase ( MPO) positive cell infiltration, COX-2 and HIF-1alpha protein expression in colorectal carcinogenesis, especially in its early phases, using immunohistochemistry and immunofluorescence confocal microscopy techniques. Paper-13760507.
Purified MPO prebound to bovine aorta endothelial cells (BAEC) and supplemented with hydrogen peroxide dose- and time-dependently abrogated the interaction of coagulation factor IX (FIX) with factor IX-binding protein (FIXBP) on the surface of BAEC reflecting oxidative modification of the binding protein. Paper-1773396.
The centromeric region and the NF1 locus, which is located between the centromere and c-erbB-2, were not amplified in any of the DCIS and invasive breast carcinomas, but co-amplification of the myeloperoxidase gene was detected in 3/5 DCIS and 1/5 invasive carcinomas with c-ErbB-2 overexpression. Paper-1031159.
Most markers of inflammation were also increased in the lavage fluids of LCS3-treated mice: MPO and elastase showed a 2.47 fold and 17 fold increase, respectively ( P < 0.05 in both cases); TNF-alpha showed a 11.1 fold increase ( P < 0.05) whereas the IL-1 alpha levels were not significantly modified. Paper-753161.
The genotype distributions of CYP1A1, CYP2E1, CYP2A6, NQO1, NAT2, mEH, MPO and GSTT1 genes were not statistically different; however, the ratio of the GSTM1 null genotype was significantly higher in patients than in controls (62.1% vs 47.2%; P = 0.019; OR, 1.83; 95% CI, 1.11-3.04). Paper-14475041.
The polymorphic frequency of 10 genetic susceptibility genes and their association with lung cancer were examined in a northern Thai population: CYP1A1 (MspI), CYP1A1 (Ile462Val), CYP2E1 (PstI), CYP2E1 (DraI), GSTM1, GSTT1, MPO (AciI), OGG1 (Ser326Cys), TP53 (Arg72Pro), and MMP1(AluI). Paper-14602111.
The formation of TGZ quinone was inhibited approximately 90% by coincubation with ascorbic acid or cysteine in the MPO reaction system but only 10 to 20% in liver microsomes, which might reflect the difference in the mechanism by which TGZ quinone is formed by P450 and peroxidase. Paper-10544989.
In this case-control study (830 non-small cell lung carcinoma (NSCLC) patients; 1119 controls) we evaluated whether the MPO -G463A polymorphism ( associated with a novel estrogen receptor binding site) modifies the association between the SOD2 Ala16Val polymorphism and NSCLC risk differently by gender. Paper-10537861.
There was no clinical benefit in either lung function or symptom scores, and no significant change in the inflammatory indices as measured by total and differential cell counts and concentrations of TNF-alpha eosinophil activation markers ECP and EPO, and neutrophil activation markers MPO and HNL. Paper-895405.
A series of novel and potent 3,4-diamino-2,5-thiadiazole-1-oxides were prepared and found to show excellent binding affinities for CXCR2 and CXCR1 receptors and excellent inhibitory activity of Gro-alpha and IL-8 mediated in vitro hPMN MPO release of CXCR2 and CXCR1 expressing cell lines. Paper-12682728.
CONCLUSIONS: Results of this study demonstrate that a Gln-supplemented enteral diet increased lymphocyte CD11a/ CD18 expressions, whereas neutrophil CD11b/ CD18 expressions, circulating intracellular adhesion molecule-1 levels, and MPO activities in various organs decreased with gut-derived sepsis. Paper-11315639.
BACKGROUND/AIMS: To clarify the clinical significance of tumor necrosis factor ( TNF) receptors in patients with myeloperoxidase (MPO)-anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis, we evaluated the cell surface expression of TNF receptor 1 ( TNFR1) and TNF receptor 2 (TNFR2). Paper-14061341.
Together with data from the present study on DNA repair genes, we did not observe significant associations between any single variant genotype for several DNA-repair and chemical-metabolizing genes ( XPD [or ERCC2], XRCC1, XRCC3, GSTM1, GSTT1, MPO, and mEH [or EPHX1]) and lung cancer. Paper-10509088.
The beneficial effect was associated with the inhibition of the colonic levels of the proinflammatory cytokines, tumor necrosis factor alpha ( TNF alpha) and interleukin 1beta (IL-1beta), and the reduction in colonic myeloperoxidase ( MPO) activity and inducible nitric oxide synthase ( iNOS) expression. Paper-15115602.
Liquid chromatography-mass spectrometry and tandem mass spectrometry analyses demonstrated that methionine and N-terminal cysteine residues were rapidly oxidized by MPO-derived HOCl but only oxidation of the N-terminal cysteine of TIMP-1 correlated well with loss of inhibitory activity. Paper-12534131.
METHODS AND RESULTS: Conditioned media from luminal, intermediate, and abluminal layers of 29 human ILTs were analysed for neutrophil markers [elastase/alpha1-antitrypsin and MMP9/NGAL complexes, myeloperoxidase ( MPO), and alpha-defensin peptides], RANTES, platelet factor 4 ( PF4), and interleukin-8 ( IL-8). Paper-13771808.
To investigate interactions between the endothelium and leukocytes in patients with sepsis, we measured soluble adhesion molecules (sE-selectin and sICAM-1), von Willebrand factor antigen ( vWf:Ag), myeloperoxidase ( MPO), and lactoferrin ( Lacto-f) as plasma markers of endothelial and neutrophil activation. Paper-1361419.
The colonic MPO and MDA levels were significantly lower in control, BBS, NTS and BBS + NTS groups than in the colitis group ( MPO levels, 24.36 +/- 8.10, 40.51 +/- 8.67 and 25.83 +/- 6.43 vs 161.47 +/- 38.24; MDA levels, 4.70 +/- 1.41, 6.55 +/- 1.12 and 4.51 +/- 0.54 vs 15.60 +/- 1.88, P < 0.05). Paper-14286186.
We evaluated the frequency of polymorphisms in the CYP2D6 (*3 and *4), EPHX1 (*2 and *3), MPO (*2), and NQO1 (*2) genes in 206 patients with childhood ALL and in 364 healthy individuals matched for age and gender from a Brazilian population separated by ethnicity (European ancestry and African ancestry), using the PCR-RFLP method. Paper-14127915.
METHODS: : Leukotriene B4 or a vehicle was administered to adult rats via celiac axis injection after pretreatment with the TRPV1 antagonist, capsazepine, or vehicle, and the severity of subsequent pancreatitis was assessed by measuring pancreatic edema, myeloperoxidase ( MPO) activity, and histological grading. Paper-16014496.
Thyroid peroxidase ( TPO) autoantibodies are heterogeneous and have been classified in terms of whether they cross-react with myeloperoxidase ( MPO), lactoperoxidase ( LPO), or thyroglobulin ( Tg) as well as by whether they inhibit TPO enzymatic activity. Paper-198841.
Six polymorphisms in five different genes were analysed: myeloperoxidase ( MPO) -129G/A and -463G/A, toll-like receptor 4 ( TLR4) Asp299Gly, interleukin-6 ( IL6) -174G/C, surfactant protein D ( SFTPD) Met11Thr and regulated upon normal T-cell expressed and secreted ( CCL5) -403G/A. Paper-13575239.
MEASUREMENTS AND RESULTS: Response to inhaled NO was assessed, and ARDS was characterized in terms of pulmonary morphology (scoring of high-resolution CT); inflammation ( BAL neutrophil count and plasma myeloperoxidase concentration); and markers of lung injury severity (oxygenation deficit and pulmonary vascular resistance [PVR]). Paper-1641608.
The concentrations of the plasma-proteins alpha 1-proteinase inhibitor (alpha-1PI), alpha 2-macroglobulin (alpha 2PI), albumin (Alb) and of the locally released proteins myeloperoxidase ( MPO), lactoferrin ( Lf), elastase ( Ela) and fibronectin ( Fib) were determined in BALF using chemiluminescence immunoassays. Paper-1203330.
Since it has been shown that alterations in innate immune pathways contribute to the risk for serious infections, we analyzed well-characterized variants in innate immune genes ( TNF, IL6, IL8, MPO, CHIT, FCGR2A, TLR2, and TLR4) to determine their possible contribution to infectious complications during therapy for pediatric AML. Paper-10992823.
Because mitochondrial manganese superoxide dismutase catalyzes conversion of superoxide radicals to H(2)O(2), with catalase neutralizing H(2)O(2) and myeloperoxidase converting H(2)O(2) to highly reactive hypochlorous acid, we hypothesized that gene variants could impact the efficacy of treatment for breast cancer and improve survival. Paper-11150819.
METHODS: In a hospital-based case-control study, we compared 125 cases and 193 controls with respect to prevalence of (1) the T-->C (val-->ala) substitution at the -9 position in the signal sequence of SOD2; (2) the G-->A substitution at the -463 position in the promoter region of MPO; and (3) the C-->T (pro-->ser) change in exon 6 of NQO1. Paper-10313181.
To clarify the role of myeloperoxidase ( MPO) in multiple sclerosis ( MS), we measured serum MPO levels in 86 Japanese patients with relapsing remitting MS, 47 with opticospinal MS (OSMS) and 39 with conventional MS ( CMS), and 85 healthy subjects by sandwich enzyme immunoassays and analyzed relationships with clinical features. Paper-12210041.
Introduction of purified eosinophil peroxidase ( EPO) into the phagosome by binding the enzyme to the surface of the zymosan particles changed the hypermetabolic characteristics of superoxide production in MPO-deficient cells to more closely resemble normal cells, but had no effect on superoxide generation by the normal monocytes. Paper-4410842.
The t(8;16)(p11;p13) fuses the MOZ ( MYST3) gene at 8p11 with CBP ( CREBBP) at 16p13 and is associated with an infrequent but well-defined type of acute myeloid leukemia (AML) that has unique morphocytochemical findings (monocytoid blast morphology with erythrophagocytosis and simultaneously positive for myeloperoxidase and nonspecific esterases). Paper-10311340.
In 24 men aged 32 to 58 years with precancerous states of the larynx, i.e., leukoplakia, papillomas and pachydermia the peripheral blood lymphocytes were cytochemically stained for N-acetyl-beta-glucosaminidase, beta-glucuronidase, acid phosphatase and glycogen; and the neutrophils were stained for alkaline phosphatase, myeloperoxidase and lipids. Paper-3243660.
RESULTS: A significant improvement was observed in DAI and histological score in rats with NPY antisense ODNs, and the increase in NPY and TNF-alpha levels, MPO activity, and the expression p-Akt and p-NF-kappaB in rats with DSS-induced colitis was significantly reduced following the administration of NPY antisense ODNs. Paper-15327685.
Metabolic enzymes involved in benzene activation or detoxification, including NAD(P)H, quinone oxidoreductase 1 ( NQO1), cytochrome P450 2E1 ( CYP2E1), myeloperoxidase ( MPO), glutathione-S-transferase mu-1 ( GSTM1), and glutathione-S-transferase theta-1 ( GSTT1), were studied for their roles in human susceptibility to benzene poisoning. Paper-9332803.
C-reactive protein ( CRP), interleukin-6 ( IL-6), tumour necrosis factor-alpha ( TNF-alpha), histamine, vascular endothelial growth factor ( VEGF), tissue inhibitor of metalloproteinases-1 (TIMP-1), plasminogen activator inhibitor type-1 ( PAI-1) and myeloperoxidase ( MPO) were determined in serum or plasma obtained on the same days. Paper-8803167.
Candidates included genes that control the transcription of metabolizing genes [ aryl hydrocarbon receptor ( AHR), AHRR and aryl hydrocarbon nuclear translocator ( ARNT)] and genes that activate/detoxify AA or PAH ( AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX1, EPHX2, NQO1, MPO, UGT1A4, SULT1A1 and SULT1A2). Paper-12955278.
The pattern of disulfide bridges is in agreement with that predicted from the X-ray crystallographic structure of canine myeloperoxidase ( MPO) (Zeng, J., and Fenna, R. E. (1992) J. Mol. Biol. 226, 185-207) to be general for the class of mammalian peroxidases, including EPO, MPO, lactoperoxidase ( LPO), and thyroid peroxidase ( TPO). Paper-8404473.
The PAL, bronchial fraction, and BAL fluids were analyzed for the following endpoints: total and differential cell counts; total protein, lactate dehydrogenase (LDH), fibronectin, interleukin-8 ( IL-8), granulocyte-macrophage colony-stimulating factor ( GM-CSF), myeloperoxidase ( MPO), and transforming growth factor-beta ( TGF beta 2) concentrations. Paper-590763.
EXPERIMENTAL DESIGN: We investigated the relationship between the risk of relapse in ALL patients and functional polymorphisms in genes encoding carcinogen-metabolizing enzymes, including CYP1A1, CYP2D6, CYP2E1, MPO, GSTM1, GSTT1, GSTP1, NAT1, NAT2, NQO1, as well as DNA-repair enzymes hMLH1, hMSH3, XRCC1, XPF, and APE. Paper-9198762.
No significant correlation was observed between PF IL-8 and neutrophil count in any group; in contrast, IL-8 was associated with NE and MPO in empyema ( r = 0.7545, and r = 0.7283; p < 0.001), tuberculosis ( r = 0.4016, p = 0.008 and r = 0.6545, p < 0.001), and nonspecific effusions ( r = 0.3748, p = 0.007 and r = 0.3085, p = 0.028). Paper-1442986.
Superoxide dismutase (SOD, 10 U/ml) prevented 1) the effects of TNF on the hemodynamic responses to U-46619 and ACh and 2) the TNF- induced decrease in NO2-. The effects of TNF on lung MPO and effluent O2- were prevented using cyclophosphamide intraperitoneally (100 mg/kg 5 days before, and 50 mg/kg 1 day before, treatment with TNF or control). Paper-7875202.
Genotyping was performed in 107 D/ R DNA pairs for gene polymorphisms of cytokines ( tumor necrosis factor-alpha [ TNF-alpha] and TNF-beta, interleukin-1 receptor antagonist [ IL-1Ra], IL-6, and IL-10), adhesion molecules ( CD31 and CD54), Fcgammareceptors (FcgammaRIIa, IIIa, IIIb), mannose-binding lectin ( MBL), and myeloperoxidase ( MPO). Paper-9276084.
These synonyms are used for gene MPO (myeloperoxidase): Myeloperoxidase.
These accession numbers are used for gene MPO: X04876 (NCBI_GENBANK__AC), Q9UCL7 (UNIPROT__AC), BC130476 (NCBI_GENBANK__AC), A1L4B8 (UNIPROT__AC).
MPO is a homologue of MPO (myeloperoxidase) from Pan troglodytes.
MPO is a homologue of MPO (myeloperoxidase) from Canis lupus familiaris.
MPO is a homologue of MPO (myeloperoxidase) from Gallus gallus.
MPO is a homologue of Mpo (myeloperoxidase) from Mus musculus.
MPO is a homologue of Mpo (myeloperoxidase) from Rattus norvegicus.
Important links !
iHOP - Information Hyperlinked over Proteins .
Concept & Implementation by Robert Hoffmann.