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The beta2- GPI gene is polymorphic with four alleles. Paper-12492968.
The beta 2 integrin Mac-1 but not p150,95 associates with Fc gamma RIIA. Paper-484990.
IGF-1 blockade, however, did not affect NeuroD within the otic epithelium. Paper-10114420.
Cyclin D1 co-operates with INSM1 and suppresses neuroD/ beta2 promoter activity. Paper-12032177.
Second, the beta2- beta3 loop of the hRBMY inserts into the major groove of the RNA stem. Paper-13162103.
Complex role of the beta 2- beta 3 loop in the interaction of U1A with U1 hairpin II RNA. Paper-9169506.
Binding of sera to EC was competitively inhibited by beta 2- GPI, LPC and oxLDL. Paper-1798716.
Antibodies to beta2 integrins also partially inhibited CD98-induced aggregation. Paper-8848471.
However, in the presence of PDX1, the synergistic action of SREBP-1c with BETA2/E47 was canceled. Paper-10973630.
This phenotype was independent of MMP9, selectins, and beta2- and alpha4-integrins. Paper-12443101.
ATP7A is a novel target of retinoic acid receptor beta2 in neuroblastoma cells. Paper-13565924.
The beta2- GPI seems to protect t-PA activity from the inhibition by PAI-1. Paper-8414619.
Our sequence data shows that the histidine at residue 47 of ADH beta 2 is encoded by CAC. Paper-6142461.
Beta1 and beta2 were expressed together with Nav1.5 or Nav1.2 in Pro5 and Lec2 cells. Paper-12209397.
The dominant antigenic targets in APS are beta 2-glycoprotein I ( beta2- GPI) and prothrombin. Paper-12396689.
The CD4 molecule interacts with the alpha2 and beta2 domains of the MHC class II molecules. Paper-833475.
In the adult pituitary gland, NeuroD1 transcripts are detected in POMC-expressing corticotroph cells. Paper-1213763.
SREBP-1c activation of the insulin promoter was markedly enhanced by co-expression of BETA2/E47. Paper-10973630.
In contrast, beta2 integrins induced stimulation of Cdc42 that was independent of Src family members. Paper-9782953.
Beta-3 versus beta-2 adrenergic agonists and preterm labour: in vitro uterine relaxation effects. Paper-8996044.
The ND1-positive cells are located in the SVZ-RMS axis and also co-express Tbr2, Tbr1 and neuroD2. Paper-13606408.
OBJECTIVE: Here we show that the RNA editing of IL-12 receptor (R) beta2 is associated with atopy. Paper-10232001.
Here we show that Finb/ RREB-1 can associate with BETA2 to enhance its transcription-activating function. Paper-9775496.
Both DNA binding and physical interaction of Finb/ RREB-1 with BETA2 are required to potentiate transcription. Paper-9775496.
Solution hybridization for the determination of mRNA for TR alpha 1, alpha 1, beta 1 and beta 2 was performed. Paper-1327451.
ISL1 physically interacts with BETA2 to promote insulin gene transcriptional synergy in non-beta cells. Paper-11119944.
The characteristic alpha1- beta2 structure of the hU2AF(65) RBD1 may interact with other proteins, such as UAP56. Paper-1986157.
BETA3, a novel helix-loop-helix protein, can act as a negative regulator of BETA2 and MyoD-responsive genes. Paper-466182.
However, PI-3K was required for beta1 integrin-, but not beta2 integrin-, mediated NF-kappaB activation. Paper-9152655.
Delta MEKK3:ER* activation induces a p38 alpha/ beta 2-dependent cell cycle arrest at the G2 checkpoint. Paper-9237351.
Transforming growth factor beta2 autocrinally mediates neuronal cell death induced by amyloid-beta. Paper-11807601.
This study also shows a novel role for PD-1 in inhibiting beta1 and beta2 integrin-mediated adhesion. Paper-11532604.
Thus HAR-TX beta 2 may prove to be a useful reagent for the targeting and elimination of HER4-positive tumor cells. Paper-195174.
The expressions of RPL10 and NEUROD1 were prominent in the MEN1 human and heterozygous mouse exocrine pancreas. Paper-13681365.
Thus, the TGF-beta/ beta2 spectrin (beta2SP) pathway may reflect a more functional 'stem/progenitor' state than CD133. Paper-13622833.
RESULTS: Tumors and MEN1 nontumorous endocrine cells showed a prominent cytoplasmatic NEUROG3 and NEUROD1 expression. Paper-13681365.
Epigenetic patterns of the retinoic acid receptor beta2 promoter in retinoic acid-resistant thyroid cancer cells. Paper-13279725.
NeuroD1 expression in human prostate cancer: can it contribute to neuroendocrine differentiation comprehension? Paper-12564061.
In contrast, activation of beta2 receptors caused no detectable effect on V2 receptor internalization in the same cells. Paper-8958266.
Moreover, Glis3 physically and functionally interacts with Pdx1, MafA and NeuroD1 to modulate Ins2 promoter activity. Paper-13757531.
Over expression of alpha M beta 2 integrin on peripheral blood human neutrophils stimulated with GM-CSF. Paper-1762917.
However, treatment of beta 2-deficient (LAD) PMN failed to induce paxillin tyrosine phosphorylation. Paper-140205.
Western blotting of the conditioned medium demonstrated increased collagen I-III, laminin beta2, and fibronectin levels. Paper-10146049.
The results revealed that most GAD67-positive interneurons expressed beta2, and 67 % also expressed alpha7 mRNA. Paper-13014017.
Talin head domain that contains the FERM domain showed binding affinity of K(d) approximately 0.5 mum with the beta2 tail. Paper-13597067.
Likewise in human cells, ICAP-1 associated specifically with the beta1 but not beta2, beta3, or beta5 tails. Paper-1708204.
Myeloperoxidase mediates cell adhesion via the alpha M beta 2 integrin (Mac-1, CD11b/ CD18). Paper-1079765.
We found that engagement of beta2 integrins on human neutrophils increased the levels of GTP- bound Rap1 and Rap2. Paper-12311213.
In contrast, cytokines like IL-5 prevent beta-1 integrin activation while promoting beta-2 integrin function. Paper-1581448.
In addition, both beta2- and PAF- mediated EGR-3 activation could be synergistically activated by CXCR4 activation. Paper-10665525.
To analyze the biological significance of the LL/ beta2 interaction, we utilized RNA interference to specifically knockdown AP-2. Paper-12112948.
Within the bHLH region, ABF-1 shows a remarkable conservation with other HLH proteins, including tal-1, NeuroD, and paraxis. Paper-1444698.
We report here a function for MRP-14 as a stimulator of neutrophil adhesion mediated by the beta 2 integrin, Mac-1. Paper-1405263.
CONCLUSIONS: beta2-containing receptors are necessary for nicotine's effects on the N40 component of the mouse auditory ERP. Paper-13608086.
Strikingly, the phenolic ring of tyrosine -7 enters into a pocket formed by the extended beta 2- beta 3 loop of the Erbin PDZ. Paper-9868479.
BETA2 activates transcription from the upstream glucokinase gene promoter in islet beta-cells and gut endocrine cells. Paper-9843628.
An SRC-dependent outside-in signalling initiated by beta2 integrins was also required for adhesion triggered by interleukin-8. Paper-10557455.
Stabilin-2 was recently shown to mediate a heterophilic interaction with integrin alpha M beta 2 via its FAS1 domain. Paper-13714647.
A chromatin immunoprecipitation assay confirmed that in vivo INSM1 is situated on the promoter region of the neuroD/ beta2 gene. Paper-12032177.
On DEAE ion-exchange chromatography ( TSK DEAE 5PW) TCF-I beta gave two peaks with TCF activity (TCF-I beta 1 and TCF-I beta 2). Paper-6289697.
Furthermore, we show that Neurod1/2/6 and Lhx1/5, which act downstream of Ptf1a, control distinct aspects of peptidergic differentiation. Paper-13547540.
By using flow cytometry, we have characterized LPS- induced expression of the beta 2 integrin CD11b/ CD18. Paper-6872059.
RANTES- induced TEM was concentration-dependent and was inhibited by Abs directed against the beta 2 integrin CD18. Paper-8224748.
Competition of HLA-DR and a beta 2 domain peptide for HIV envelope glycoprotein gp120 binding to CD4. Paper-221404.
The data suggest that beta1-strand interacts with beta2, beta2 with beta3, beta3 with beta4, and beta4 with beta5. Paper-12851017.
These results show that eotaxin-2 rapidly reduced alpha4 integrin function while increasing beta2 integrin function. Paper-8426856.
Transglutaminase interacts directly with multiple integrins of beta1 and beta3 subfamilies, but not with beta2 integrins. Paper-2124843.
Novel transcriptional potentiation of BETA2/ NeuroD on the secretin gene promoter by the DNA- binding protein Finb/ RREB-1. Paper-9775496.
MCP-1 stimulated beta1 integrin-dependent, but not beta2 integrin-dependent cell adhesion in a time-dependent manner. Paper-8778659.
Pdx1 and BETA2/neuroD1 participate in a transcriptional complex that mediates short-range DNA looping at the insulin gene. Paper-12772870.
Here, we elaborate on the recent finding that auxiliary subunits of voltage-gated sodium channels ( beta2 and beta4) are BACE substrates. Paper-13522252.
Surprisingly, the beta2 integrin- induced activation of Rap2 was not regulated by any of the signaling pathways mentioned above. Paper-12311213.
In a solution binding assay, both beta1 and beta2 competed with each other for binding to immobilized repeat nucleoporin Nup98. Paper-1010990.
In isolated mature pollen the beta 4- tubulin overwhelmingly predominates the ubiquitously expressed beta 2- tubulin isotype. Paper-5808093.
BETA2 induces cell cycle arrest and apoptosis in addition to activating secretin gene expression. Paper-8444662.
The sequence of the DRw53-associated DR7 beta 2 chain is identical to the reported sequence of the DRw53- associated DR4 beta 2 chain. Paper-5164791.
Moreover, inhibition of neurogenesis by skp2 occurs upstream of the proneural gene encoding NeuroD and prior to cell cycle exit. Paper-13450657.
Hemoglobin Fannin-Lubbock [alpha2 beta 2 119 ( GH2) Gly replaced by Asp]. A new hemoglobin variant at the alpha1 beta 1 contact. Paper-2499927.
Both, MoDCs and CD34DCs expressed the alpha integrins LFA-1, Mac-1, CR4, VLA-4, VLA-5 and the beta2 integrin CD18. Paper-13434578.
PMN interactions with non-laminin ECM ligands thus seem to be mediated either exclusively by beta 2 integrins or by nonintegrin molecules. Paper-7587730.
It involved beta2 integrins and Fcgamma receptor, because it was prevented by anti-CD18 antibodies and was not observed with anti- PR3 F(ab')(2). Paper-13355839.
Changes in active renin and plasma renin activity (PRA) were used as indirect witness of the dobutamine- induced beta 2-stimulation. Paper-185101.
Casein kinase II consists of catalytic (alpha) and regulatory (beta) subunits complexed into a heterotetrameric alpha 2 beta 2 structure. Paper-6955812.
Phospholipids in EC membranes may thus be antigenic epitopes. beta 2- GPI may bind to these phospholipids, and become an autoantigen. Paper-1798716.
Constitutively activated PKCbeta1 and beta2 also enhanced the transcription of c-fos in transient transfection luciferase reporter assays. Paper-12344927.
Cutaneous lymphocyte antigen expression on activated lymphocytes and its association with IL-12R (beta1 and beta2), IL-2Ralpha, and CXCR3. Paper-11627450.
Retinoschisin octamerisation is implicated in cell-cell interactions and cell adhesion perhaps by interacting with beta2 laminin. Paper-13163044.
Chronic PKC- beta2 activation in HT-29 Cl.19a colonocytes prevents cAMP- mediated ion secretion by inhibiting apical membrane CFTR targeting. Paper-12059876.
Cyclin D1 may be recruited to BETA2 by binding to the C-terminal domain of the p300 coactivator, downstream from the BETA2-binding site. Paper-9157829.
In sector CA1, mRNA levels of subunits alpha1, alpha5, beta2, beta3, and gamma2 decreased by 35-54% in spite of only a minor (9%) cell loss. Paper-9146276.
Transforming growth factor beta 1 and beta 2 induce down-modulation of thrombomodulin in human umbilical vein endothelial cells. Paper-397604.
GABA(A) R beta2/3 subunits were also expressed in a few VIP- or NOS-IR neurons, the cholinergic or non-adrenergic, non-cholinergic (NANC) neurons. Paper-12137899.
INSM1 functions as a transcriptional repressor of the neuroD/ beta2 gene through the recruitment of cyclin D1 and histone deacetylases. Paper-12032177.
Gene expression of nAChR subunits alpha1, alpha2, alpha 4, alpha 5, alpha 6, alpha 7, beta1, beta2, and beta 4 was detected in HDPCs. Paper-12973311.
Three COOH-terminal residues (aa 758-760) were essential for beta2- induced accumulation of Rho at complement receptor 3 ( CR3) phagosomes. Paper-11359489.
RESULTS: Increased Beta 1 (12.5-16 Hz) and Beta 2 (16.5-20 Hz) absolute power was observed in alcohol-dependent subjects at all loci over the scalp. Paper-9587362.
FMLP stimulated neutrophil shape change and the surface expression of the beta 2 integrins CD11b/ CD18 and CD11a/ CD18. Paper-143528.
Parathyroid hormone regulates transforming growth factor beta1 and beta2 synthesis in osteoblasts via divergent signaling pathways. Paper-8465438.
CD63 has been reported to associate with beta1 and beta2 integrins, but the mechanism of signal transduction by CD63 is not clear. Paper-11497760.
In M phase, the expression of alpha1, alpha2, beta1 and beta2 isoforms of p70S6K increased noticeably, while the expression of 4EBP-1 decreased. Paper-12382825.
BACE1 produced complex effects on sodium channel gating that could be only partially explained by beta2/ beta4 cleavage. Paper-13522252.
Overexpression of cyclin D1 and HDAC-3 significantly enhanced the transcriptional repression activity of INSM1 on the neuroD/ beta2 promoter. Paper-12032177.
BR-trainees showed a lower theta rhythm than the controls before the training session began and lower beta2 power before, during and after the session. Paper-9626399.
This beta 2 integrin- induced phosphorylation of PLC gamma 2 occurred in parallel with an increased accumulation of Ins(1,4,5)P3. Paper-619298.
Significantly elevated levels of antibodies to beta2- GPI were found in all patients with definite antiphospholipid syndrome (median = 91 AU). Paper-1127337.
In contrast, co-expression of PDX-1 but not NeuroD inhibits activation of the INGAP-promoter driven by PAN-1, PMA or LIF stimulation. Paper-11318689.
Antibodies against CD29 (beta1 integrin), but not against CD18 ( beta2 integrin) or CD31 ( PECAM-1), inhibited TF expression. Paper-9274696.
As expected, tumors that have high levels of ASCL1 also express neuroendocrine markers, and we found that this is accompanied by increased levels of NEUROD1. Paper-13274991.
Of patients, 91% carried DQ2 and/or DQ8 heterodimers, 6% only had beta2 chain, 2% was alpha5 positive, and four were DQ2/DQ8/ beta2/alpha5 negative. Paper-13568424.
Structural analysis of anti-DR1 allorecognition by using DR1/H-2Ek hybrid molecules. Influence of the beta 2-domain correlates with CD4 dependence. Paper-6871365.
Thereafter 166 paraffin sections from normal and neoplastic prostates were stained with NeuroD1, chromogranin-A, synaptophysin, and CD56 antibodies. Paper-12564061.
RRIG1 mediates effects of retinoic acid receptor beta2 on tumor cell growth and gene expression through binding to and inhibition of RhoA. Paper-12068317.
The clones reactive to SEA and SEB expressed various V beta genes while T cell reactivity to TSST-1 correlated with the V beta 2 expression. Paper-424825.
The resulting anti- PSCA scFv 7F5 was fused to the beta2 constant region derived from the beta-chain of a TCR and to the CD3zeta-signaling domain. Paper-13255451.
The NeuroD1-containing heterodimers specifically recognize and activate transcription from the POMC promoter E box that confers transcriptional specificity. Paper-1213763.
At the same time, IFN- beta2 and a 26 kDa protein in the fibroblasts were independently cloned and found to be identical to B cell stimulatory factor-2. Paper-12081788.
In particular, the Neurod1/2/6 factors are essential for dynorphin and galanin expression, whereas the Lhx1/5 factors are essential for NPY expression. Paper-13547540.
5 These findings indicate that TNF-alpha- stimulated GPI-80 release from human neutrophils depends upon adherence via beta2 integrins. Paper-9626825.
Our main finding is that the Ca(V)beta subunit GK domains, from either beta1b or beta2, are sufficient to restore voltage dependence to G protein modulation. Paper-13528732.
This was demonstrated in experiments in which we found that ENA-78 induces inside-out signaling of beta2 integrins on the PMN surface, as does IL-8. Paper-1130257.
Dynamic partitioning into lipid rafts controls the endo-exocytic cycle of the alphaL/ beta2 integrin, LFA-1, during leukocyte chemotaxis. Paper-11467171.
For the solution pathway the linear dipeptides were synthesized by coupling of the BOC- protected L-alpha-amino acid with the beta2-amino acid ester (EDC/HOBT). Paper-10013740.
Insulin resistance is prevalent in heart failure (HF) patients, and beta2 adrenergic receptors ( beta2-AR) are involved in glucose homeostasis. Paper-13514676.
This DAB-like gene is 63% identical to the X. maculatus DXB sequence in the conserved beta2- encoding exon and was mapped to new unassigned linkage group LG U24. Paper-1558763.
Mutational analysis of a proximal enhancer in the secretin gene identified several cis-acting elements in addition to the E-box binding site for BETA2. Paper-9775496.
These data strongly suggest that synchronous activation of both the ERK and PI3K pathways is essential for collagen I-III and laminin beta2 production. Paper-10146049.
The NeuroD1/ BETA2 sequences essential for insulin gene transcription colocalize with those necessary for neurogenesis and p300/ CREB binding protein binding. Paper-1713344.
Unlike pharmacologic inhibition of PKA, AKAP peptide- induced adhesion was PKC dependent and did not affect beta2 integrin expression or CBRM1/5 binding. Paper-9479774.
Association of oestrogen receptor beta 2 ( ER beta 2/ ER beta cx) with outcome of adjuvant endocrine treatment for primary breast cancer--a retrospective study. Paper-13399981.
Conversely, beta(2-DeltaN) modulated Nav1.2 gating virtually identically to beta2, confirming that beta2 N- linked sugars have no impact on Nav1.2 gating. Paper-12209397.
Histone deacetylase ( HDAC) inhibitors have been shown to reverse repression of some genes, including retinoic acid (RA) receptor beta2. Paper-12107835.
The beta2 gene locus was closely linked to the endothelin-2 ( ET-2) locus (LOD of 13.0), which has been shown to cosegregate with blood pressure. Paper-1495215.
The receptors on which GLC756 binds (D1, D2, D4, alpha-1, alpha-2, 5-HT1A, 5-HT2C, 5-HT1D, 5-HT2 A, beta-1, and beta-2) were suggested to play a role. Paper-12242420.
Both genes are transiently expressed in vestibular and then in cochlear neuroblasts, while differentiated neurons express Islet1, Tuj1 and TrkC, but not NeuroM or NeuroD. Paper-13037049.
Rewiring the retinal ganglion cell gene regulatory network: Neurod1 promotes retinal ganglion cell fate in the absence of Math5. Paper-13012760.
Heterologous coexpression studies demonstrated that beta2 induced larger currents through rabbit and human cardiac CaV1.2 pore subunits than beta3 isoforms. Paper-9740806.
Prealbumin and haemopexin showed correlations preoperatively; alpha1 antitrypsin and beta2 glycoprotein only correlated at three months postoperatively. Paper-2792335.
The beta2 integrin subfamily may regulate the growth of hematopoietic cells in hematopoiesis in vivo and/or cause the abnormal growth of leukemia cells. Paper-1322032.
We report that IFN-beta increases IL-12- induced STAT4 phosphorylation and up-regulates IL-12 receptor beta1 and beta2 expression. Paper-13257037.
Progressive loss of PAX6, TBR2, NEUROD and TBR1 mRNA gradients correlates with translocation of EMX2 to the cortical plate during human cortical development. Paper-13065430.
Signal regulatory protein alpha negatively regulates beta2 integrin-mediated monocyte adhesion, transendothelial migration and phagocytosis. Paper-13013187.
All 8 tumors with reduced levels of RAR- beta2 mRNA expression showed methylation of the promoter and the first exon expressed in the RAR- beta2 transcript. Paper-9171135.
Induction and functional characterization of beta2-microglobulin (beta2-mu)-free HLA class I heavy chains expressed by beta2-mu-deficient human FO-1 melanoma cells. Paper-1574919.
In this article, current knowledge will be reviewed that places ahnak into the context of cardiac L-type Ca2+ channel function by its interaction with the beta2 subunit. Paper-12382768.
These data suggest that protein C could be a target of aCL by making a complex with CL and beta2- GPI, leading to protein C dysfunction. Paper-1480882.
This motif is found at tyrosine residue 800 in the beta2 subunit of the interleukin-12 receptor and is required for DNA binding and transcriptional activity of STAT4. Paper-1719852.
An asymmetric contribution to gamma-aminobutyric type A receptor function of a conserved lysine within TM2-3 of alpha1, beta2, and gamma2 subunits. Paper-12041627.
Analysis of the INGAP promoter suggested that candidate regulators of INGAP expression include the transcription factors PDX-1, NeuroD, PAN-1, STAT and AP-1. Paper-11318689.
No transcript for IL-12 receptor beta1 subunit was detected in freshly isolated and activated T-LPLs whereas the beta2 subunit mRNA was consistently found in T-LPL samples. Paper-1686349.
During expansion, cells expressed transcription factors implicated in islet development such as Isl1, Nkx2.2, Nkx6.1, nestin, Ngn3, Pdx1, and NeuroD. Paper-12853396.
Herein, we report a transmembrane beta subunit ( beta2) that yields inactivating MaxiK currents on coexpression with the pore-forming alpha subunit of MaxiK channels. Paper-1823177.
Rapid and prominent up-regulation of high-affinity receptor for immunoglobulin G ( Fc gamma RI) by cross- linking of beta 2 integrins on polymorphonuclear leukocytes. Paper-8384099.
Although heparin is routinely used in the treatment and prophylaxis of APS patients, the primary heparin-binding site within beta2- GPI has not been identified. Paper-9154537.
A further chromatin immunoprecipitation assay confirmed that HDAC-3 occupies this same region of the neuroD/ beta2 promoter, by forming a transcription complex with INSM1. Paper-12032177.
Ang1 also blocked VEGF- induced translocation of protein kinase C (PKC) and beta2 to the membrane, but had no effect on activation of PKC alpha. Paper-10283266.
The E-box activator is a heteromeric complex composed of a beta-cell-enriched factor, BETA2/ NeuroD, and ubiquitously distributed proteins encoded by the E2A and HEB genes. Paper-1413249.
Chemoattractant signals and beta 2 integrin occupancy at apical endothelial contacts combine with shear stress signals to promote transendothelial neutrophil migration. Paper-10892746.
3. Minor changes in the ring substituents of the drugs reduced their affinity to the alpha 6 beta 2 gamma 2 subtype more pronouncedly than to the alpha 1 beta 2 gamma 2 subtype. Paper-7630389.
Vav1 phosphorylation is induced by beta2 integrin engagement on natural killer cells upstream of actin cytoskeleton and lipid raft reorganization. Paper-10028106.
We further demonstrated that ER-beta1 is the only fully functional isoform, whereas ER- beta2, - beta4, and -beta5 do not form homodimers and have no innate activities of their own. Paper-12205442.
As mutation analysis of E3 box showed a decrease in the enhancer activity to the basal level, it showed that the E3 box is important to activate the NeuroD transcription. Paper-1922396.
The beta1-, beta2- and beta3-AR mRNAs were all positively expressed in detrusor smooth muscle preparations in a reverse transcription polymerase chain reaction assay. Paper-1840370.
The beta2 integrin- triggered relocalization of Rac1 to the cytoskeleton was enabled by a PI 3-kinase- induced dissociation of Rac1 from LyGDI. Paper-9782953.
These results suggested that maintenance of the property of insulin- producing cells derived from ES cells could be achieved by synergistic expression of Pdx-1 and NeuroD1. Paper-13384946.
Levels of insulin, transforming growth factor (TGF) beta2, TGFalpha and epidermal growth factor receptor ( EGFR) were measured by enzyme-linked immunosorbent assay ( ELISA). Paper-12021437.
RESULTS: Mutations in the cholinergic receptor, neuronal nicotinic, alpha2, alpha4 and beta2 subunit genes have been found in autosomal dominant nocturnal frontal lobe epilepsy. Paper-13675348.
BETA2 is a transcription factor in the basic helix-loop-helix (bHLH) family, which activates expression of tissue-specific genes in several developmental systems. Paper-11119944.
We have identified an INSM1 binding site in the neuroD/ beta2 promoter and demonstrated transcriptional repressor activity of INSM1 by transient transfection assay. Paper-12032177.
We now show that NeuroD1 is expressed in corticotroph cells of the pituitary gland and that it is involved in cell-specific transcription of the proopiomelanocortin ( POMC) gene. Paper-1213763.
Measurement of beta 2- GPI plasma levels in 19 LAC positive patients, 40 LAC negative patients and 15 controls showed no difference in beta 2- GPI levels. Paper-7279240.
Conversely, TLRs and cytokines modulate ITAM-mediated signaling, by means including activation of beta2 integrins that are coupled to the ITAM-containing adaptors DAP12 and FcRgamma. Paper-13673271.
In conclusion, the antagonistic effect on alpha-2 adrenoceptors and the agonistic effect on beta-2 adrenoceptors were identified as mechanism for the TNF-alpha decreasing effect of GLC756. Paper-12242420.
Insulin-like growth factor binding protein 3 mediates retinoic acid- and transforming growth factor beta2-induced growth inhibition in human breast cancer cells. Paper-517682.
The non-proteolytic BACE1 effect on Nav1.2 current was confirmed in murine neuroblastoma cells, which express sodium channels endogenously, but lack beta2 and beta4. Paper-13522252.
Beta2 integrins/ ICAM-1 adhesion mechanisms were examined and the results indicate LFA-1 and Mac-1 cooperate to mediate the PMN-EC-melanoma interactions under shear conditions. Paper-10975944.
In turn, monocytic cells induced CD69 expression and IFN-gamma production in NK cells, an effect that was mediated mainly by beta2 integrins and membrane- bound IL-15. Paper-12414883.
Only a subset of ACTH-negative tumours expressed NAK-1/ Nur77, and NeuroD1 expression was detected in approximately 50% of the tumours regardless of their secretory status. Paper-10843358.
The p110delta isoform of PI3K differentially regulates beta1 and beta2 integrin-mediated monocyte adhesion and spreading and modulates diapedesis. Paper-12153520.
Promoter hypermethylation of the retinoic acid receptor beta2 gene is frequent in acute myeloid leukaemia and associated with the presence of CBFbeta- MYH11 fusion transcripts. Paper-11843558.
Male rats were treated with propranolol (beta1- and beta2-antagonist), atenolol (beta1-antagonist), or phentolamine ( alpha1- and alpha2-antagonist) dissolved in drinking water. Paper-13685209.
Immunohistochemically, the tumor cells revealed positive expression to NeuroD and faint expression to mASH1 ( hASH1): both essential transcriptional factors for normal neural development. Paper-12978370.
Tyrosine phosphorylation of the beta2 subunit of clathrin adaptor complex AP-2 was detected in three types of cells treated with epidermal growth factor ( EGF). Paper-10039336.
Taken together, these results demonstrate that hypoxia induces leukocyte beta2 integrin expression and function by transcriptional mechanisms dependent upon HIF-1. Paper-10470965.
TGF-beta 1- stimulated adhesion of human mononuclear phagocytes to fibronectin and laminin is abolished by IFN-gamma: dependence on alpha 5 beta 1 and beta 2 integrins. Paper-467670.
Moreover, signals in pathological CNS extracts of ALS mice were more effective in promoting hMSCs neurogenic differentiation than those in physiological extracts of normal adult mice. Paper-13427887.
These results suggest that impaired beta2 integrin function in WASp-deficient PMNs may contribute substantially to the clinical immunodeficiency suffered by WAS patients. Paper-12184189.
We propose that cathepsin X causes cytoskeletal rearrangements and stimulates migration of T lymphocytes by modulating the activity of the beta2 integrin receptor LFA-1. Paper-12963944.
In addition, the HMGB1- induced migration of EPCs on fibronectin and fibrinogen was significantly inhibited by antibodies against beta1 and beta2 integrins, respectively. Paper-12448908.
Replacement of beta2- with beta3-TM generated a chimaeric alphaLbeta2 of an intermediate affinity that adhered to ICAM-1 (intercellular adhesion molecule 1) but not to ICAM-3 constitutively. Paper-12752546.
There was less restricted compartment-specific expression of TBR2, NEUROD and TBR1 mRNA than in the rodent, where the gradients of expression were similar to that of PAX6 prior to 9 PCW. Paper-13065430.
We studied the potential contribution of nine positional and functional candidate genes: TBR-1; GAD1; DLX1; DLX2; cAMP-GEFII; CHN1; ATF2; HOXD1 and NEUROD1. Paper-10191807.
Solution structure of the PDZ2 domain from cytosolic human phosphatase hPTP1E complexed with a peptide reveals contribution of the beta2- beta3 loop to PDZ domain-ligand interactions. Paper-9502215.
Alpha1, alpha2, beta1, beta2 and gamma1 chains were detected in nerves of salivary tissue and alpha1, alpha3, beta1, beta2 and gamma1 chains and epiligrin in blood vessels. Paper-1842705.
The results revealed that the loop region of the U2 snRNA hairpin IV interacted mainly with three regions of the U2B" protein: 1) beta 1-helix A, 2) beta 2- beta 3, and 3) beta 4-helix C. Paper-9021611.
Telmisartan therapy significantly decreased the lymphocyte beta2 integrin MAC-1 expression, whereas hs-CRP, IL-6, s-ICAM and sL-selectin remained unaltered. Paper-12181033.
(-)-Norepinephrine, the unspecific beta-adrenergic agonist (-)-isoproterenol, and the beta 2-specific agonist terbutaline mimicked the effect of epinephrine on LDL-receptor activity. Paper-5955105.
Human eotaxin induces alpha 4 and beta 2 integrin-dependent eosinophil accumulation in rat skin in vivo: delayed generation of eotaxin in response to IL-4. Paper-1376970.
The beta2- GPI transcriptional signal of 1.5 kb was detected in Northern blot analysis and its 326-amino-acid sequence was found to be one of the most proline-rich eukaryotic proteins. Paper-12492968.
PPlike cells show a strong upregulation of Ipf1/ Pdx1, p48, Isl-1 and Nkx6.1, but not Ngn3, NeuroD/ Beta2 or Pax4. Paper-12247869.
Transforming growth factor beta2-induced myofibroblastic differentiation of human retinal pigment epithelial cells: regulation by extracellular matrix proteins and hepatocyte growth factor. Paper-12027441.
Recombinant Escherichia coli-derived human tumor necrosis factor ( TNF) induces the 1.3-kilobase beta 2 interferon ( IFN-beta 2) mRNA in human diploid fibroblasts (FS-4 strain). Paper-5202435.
CONCLUSIONS: beta2 Integrin is up-regulated during an acute attack of FMF in dissociation with LS expression, suggesting a unique nonchemoattractant-mediated neutrophil activation. Paper-10350361.
These included screening coagulations tests, tests for lupus anticoagulant (LA), IgG and IgM antibodies to anticardiolipin antibodies (ACA), beta2 glycoprotein 1 (beta2GP1) and annexin V. Paper-13091099.
The E1 decarboxylase component of the human branched-chain ketoacid dehydrogenase complex comprises two E1alpha (45.5 kDa) and two E1beta (37.5 kDa) subunits forming an alpha2 beta2 tetramer. Paper-1453843.
In the present study, we plated human neutrophils on surface-bound anti-beta 2 ( CD18) antibodies and found that the small GTP-binding protein p21ras is activated by beta 2 integrins. Paper-619220.
Efficient internalization has been obtained with HLH domains derived from bHLH proteins, NeuroD/ BETA2, Neurogenin3, and Mitf, in various cell types including stable cell lines and primary cells. Paper-12076962.
Interestingly, the NeuroD1 heterodimers activate transcription in synergy with Ptx1, a Bicoid-related homeodomain protein, which also contributes to corticotroph specificity of POMC transcription. Paper-1213763.
Also like Ptx1, the Ptx1b, Ptx2a, and Ptx2b transcription factors synergize with the structurally unrelated factors SF-1, Egr-1, Pit1, and NeuroD1/ Pan1 to activate promoter-specific transcription. Paper-8395505.
The basic helix-loop-helix protein BETA2/ NeuroD activates transcription of the secretin gene and is essential for terminal differentiation of secretin-producing enteroendocrine cells. Paper-9775496.
The condition is caused by mutations in the LAMB2 gene leading to complete loss of function of the gene product laminin beta2, an essential component of the glomerular and other basement membranes. Paper-12269351.
Antibody-induced engagement of beta 2 integrins on adherent human neutrophils triggers activation of p21ras through tyrosine phosphorylation of the protooncogene product Vav. Paper-619220.
Finally, we find that p160ROCK signaling negatively regulates integrin adhesions and that inhibition of RhoA results in an accumulation of beta2 integrin in the unretracted tails. Paper-8849928.
These results show that pathological condition of ALS is endowed with capacity to induce hMSCs neurogenic differentiation and hMSCs have shown a potential candidate in cellular therapy for ALS. Paper-13427887.
Separate expression of BETA2, E2A, or PDX1 led to modest (<10-fold) activation of the insulin promoter, whereas co-expression of the three proteins produced synergistic, high level activation (160-fold). Paper-2102769.
Although cryopreservation of lymphocytes did not modify the expression of beta1 and beta2 integrins it produced a marked reduction in the percentage of CD4+ and CD8+ T cells bearing CD62L. Paper-9396521.
Beta2- glycoprotein I, ( Beta2- GPI) a natural anticoagulant, is involved in the regulation of protein S anticoagulant activity by preventing the binding of protein S to C4b-binding protein. Paper-13146654.
Based on our findings, we propose a model whereby Pdx1 and BETA2/ NeuroD1 physically interact to form a nucleoprotein complex on the insulin gene that mediates formation of a short DNA loop. Paper-12772870.
OBJECTIVE: To investigate polymorphisms of the beta2 and beta3 adrenoceptor (BAR-2 and BAR-3, respectively) genes associated with insulin-resistant polycystic ovary syndrome ( PCOS) pathogenesis. Paper-12126322.
These results suggest that glucocorticoids impair insulin synthesis in HIT-T15 cells by decreasing PDX-1 and BETA2/ NeuroD and that enhancement of HES-1 expression is involved in this regulation. Paper-9061306.
Treatment of sensitive HL60 cells with 1,25D resulted in predominantly nuclear localization of C/ EBP isoforms beta-2 and beta-3, while a large proportion of C/EBPbeta-1 remained in the cytoplasm. Paper-12039977.
The resultant model predicts that the betaM3 residue beta2M286, implicated in anesthetic binding, faces the adjacent alpha1- M1 segment and not into the beta2 subunit interior as some models have suggested. Paper-13661382.
We explored the sequence of activation of certain transcription factors known to be essential for the beta cell phenotype: PDX-1, Beta2/ NeuroD, and hepatocyte nuclear factor 3beta ( HNF3beta). Paper-9513652.
Similarly, the IL-10 induced modulation of the beta2 integrin CD11b/ CD18 adhesion molecule expression was only observed on GM-CSF-preactivated neutrophils and monocytes. Paper-1688403.
We show that IL-2 induces tyrosine phosphorylation of a 125-kDa protein and homotypic adhesion in beta2 integrin (CD18)-positive but not in beta2-integrin-negative T cells. Paper-1469062.
In the mature beta cell Pdx1, MafA, beta2, and Nkx2.2 play important roles in regulating expression of insulin and to some extent other genes responsible for maintaining beta cell function. Paper-13048514.
The majority of the MODY subtypes are caused by mutations in transcription factors that include hepatocyte nuclear factor (HNF)-4 alpha, HNF-1 alpha, PDX-1, HNF-1 beta, and NEURO-DI/ BETA-2. Paper-9625808.
We show that RRM2 binds to RNA in a new way, by using a tryptophan within a conserved SWQLKD motif that resides on helix alpha1, together with amino acids from strand beta2 and a histidine on loop 5. Paper-13363806.
SAR studies led to the identification of benzenesulfonamide derivative 20, a 6.3 nM beta 3 agonist which shows 30-fold selectivity for beta 3 agonist activity over beta 1 and beta 2 receptor binding. Paper-1692235.
These experiments point toward the LT-alpha 1/ beta 2 complex as the predominant membrane form of LT on the lymphocyte surface, and this complex is the primary ligand for the LT-beta receptor. Paper-143530.
FoxO1 inhibits beta cell proliferation through suppression of Pdx1 by competing with FoxA2 and protects against beta cell failure induced by oxidative stress through NeuroD and MafA induction. Paper-12558363.
CONCLUSIONS/INTERPRETATION: Common variants in the beta2- and beta3- adrenoceptor genes are associated with increased fasting insulin and NEFA concentrations and could increase susceptibility to Type II diabetes. Paper-8968245.
Recently, it was reported that certain human tumor cells express the beta 1 integrins and that small cell lung cancer ( SCLC) cell lines express the beta 2 integrin Mo1 (alpha M/ beta 2). Paper-6903323.
Mutational analysis of nicotinic acetylcholine receptor beta2 subunit gene ( CHRNB2) in a representative cohort of Italian probands affected by autosomal dominant nocturnal frontal lobe epilepsy. Paper-9431855.
These findings indicate that in addition to induction of CD11a/ CD18-mediated cell adhesion, the ICAM-2 peptide may also serve as a " trigger" for high avidity ligand binding of other beta 2 integrins. Paper-226929.
Hydroxyurea suicide showed that this was due to a decrease in the number of CFU-C in S phase. beta 2 blocking agents are able to decrease the number of normal hematopoietic cells entering S phase. Paper-3915600.
Our data suggest that cPLA2 activation and its catalytic product platelet- activating factor play an essential role in regulating beta 1 and beta 2 integrin-dependent adhesion of eosinophils. Paper-1995001.
BETA2/ NeuroD protein is important for regulating insulin gene transcription and for the terminal differentiation of islet cells, including insulin- and glucagon-producing cells. Paper-12450083.
Blockade of beta2 integrins and membrane- bound IL-15 inhibited TNF production, whereas TNF synthesis increased in the presence of anti-CD48 and anti-CD244 ( 2B4) monoclonal antibodies. Paper-12414883.
We reported that BETA2/ NeuroD protein can permeate several cell types, including pancreatic islets, because of an arginine- and lysine-rich protein transduction domain ( PTD) sequence in its structure. Paper-12450083.
To gain further support for an involvement of PLC- induced Ins(1,4,5)P3 formation in the beta 2 integrin-induced Ca2+ signal, we searched for the molecular event(s) underlying the effects of U73122. Paper-619298.
The TIA-1 RRM2 adopts the RRM fold (betaalphabetabetaalphabeta) and possesses an extra beta-strand between beta2 and beta3, which forms an additional beta-sheet with the C-terminal part of beta2. Paper-12826239.
We conclude that Pax6 is critical for glucagon biosynthesis and processing by directly and indirectly activating the glucagon gene through cMaf and Beta2/ NeuroD1, as well as the PC2 and 7B2 genes. Paper-13686902.
Twelve CpG islands (AR, CDKN1C, DLC1, DRD2, GATA4, GDNF, GRIN2B, MTHFR, MYOD1, NEUROD1, ONECUT2 and TFAP2A) showed significant methylation in over 85% of tumors. Paper-12767457.
We now show that immobilized SLC strongly induces beta2 integrin- mediated binding of T lymphocytes of naive phenotype and B lymphocytes to ICAM-1 under static conditions. Paper-1655182.
Similarly, IGF-1 or Mn/MgATP, but not insulin, treatment of immunoaffinity-purified alpha beta heterodimeric IGF-1 receptors induced the formation of an alpha 2 beta 2 heterotetrameric IGF-1 receptor complex. Paper-6452853.
Mutagenesis studies of the beta2 receptor tail revealed that the optimal C-terminal motif for binding to the first PDZ domain of NHERF is D-S/T-x-L, a motif distinct from those recognized by other PDZ domains. Paper-1515083.
The relative distribution of the 90 families fitting maturity-onset diabetes of the young ( MODY) criteria was 63% HNF-1alpha, 2% HNF-4alpha, 0% IPF-1, 1% HNF-1beta, 0% NeuroD1/ BETA2, and 20% glucokinase. Paper-8698648.
Several Sak residues located within the unique alpha-helix and the beta2 strand do not contribute to the binding epitope but are essential to induce plasminogen activating potential in the Sak:microPli complex. Paper-1924123.
Differentiated cells express the cytoskeleton-associated protein tau and other typical neuronal markers, such as Map2, Ngn1, NeuroD, Mash1, and GluR which are also expressed in primary human fetal neurons. Paper-12384899.
These data single out the alpha2/ beta2/gamma3 heterotrimer as an important actor in exercise- regulated AMPK signalling in human skeletal muscle, probably mediating phosphorylation of ACCbeta. Paper-12356608.
In contrast, expression levels of Mash1, Ngn1, and NeuroD were significantly higher in Tlx3-expressing cells after neural induction for 4 days compared with those in cells expressing the control vector. Paper-12784183.
Altogether these results indicate that CD45 tyrosine phosphatase plays a relevant role in the regulation of both intracellular signaling and cell adhesion induced through ICAM-3 and beta 2 integrins. Paper-8225137.
Pneumolysin-independent responses included down-regulation of the genes encoding CD68, CD53, CD24, transforming growth factor beta2, and signal transducers and activators of transcription 1. Paper-9877668.
The association of gelsolin and actin was specific for PLCgamma1 because immunoprecipitates of PLCs beta2, beta3, gamma2 and delta1, which are also expressed in human platelets, did not contain detectable gelsolin or actin. Paper-1024340.
This present study was designed to use conditioned medium to investigate whether signals from pathological condition of ALS were competent to induce a program of neurogenic differentiation in expanded cultures of hMSCs. Paper-13427887.
CONCLUSIONS: HKa domains 3 and 5 may contribute to the pathogenesis of inflammatory diseases by releasing IL-1beta from human monocytes using intracellular signaling pathways initiated by uPAR, beta2 integrins and gC1qR. Paper-12239683.
In addition, VDR mediates a ligand-dependent repression of the response of the retinoic acid receptor beta2 promoter to retinoic acid, and the helix 3 and helix 12 mutants were unable to mediate transrepression. Paper-1848128.
Fibrosis-stimulating growth factors (transforming growth factor beta1, transforming growth factor beta2, bone morphogenetic protein 2, and endothelial growth factor) were expressed at significantly higher levels in PV-CD34(+) cells. Paper-11505087.
Thus, engagement of ligands on extracellular matrix and endothelium by the beta2 integrins Mac-1 and LFA-1 plays a role in delaying apoptosis in PMN recruited in response to LPS and TNF-alpha. Paper-10480557.
JNK activation was attenuated by blocking antibodies to beta2 integrins, the tyrosine kinase inhibitors, genistein, and tyrphostin A9, a Pyk2-specific inhibitor, and piceatannol, a Syk-specific inhibitor. Paper-8703823.
Here we identify the most carboxyl-terminal ahnak region ( aa 5262-5643) to interact with recombinant beta2a as well as with beta2 and beta1a isoforms of native muscle Ca2+ channels using a panel of GST fusion proteins. Paper-9526612.
However, the number of tumors per mouse did not correlate with the RARbeta-isoform expression levels. beta-carotene alone after 3 mo of supplementation mildly but significantly increased levels of RARbeta1, beta2, and beta4. Paper-12170962.
Islet beta cell-specific transcription of the insulin gene is mediated through the binding of the islet-enriched PDX-1, BETA2, and MafA transcription factors to conserved 5'-flanking region regulatory elements. Paper-10821617.
Firstly, (15)N transverse relaxation rates in the native state indicate that the regions around N10, Q27, the loop between beta2 and beta4 strands, and K87 at the C-terminal are potential unfolding initiation sites in the protein. Paper-12382604.
OBJECTIVES: The present study reports the clinical and histological features of 14 cases of prostate adenocarcinoma coupled with their expression of the TGF isoforms beta2 and beta3, as well as their receptor endogline ( CD105). Paper-10225010.
Truncation and site-directed mutagenesis of putative cis -elements within this region showing an atypical TATA box and a HNF-1 (hepatic nuclear factor-1) element were both essential for the beta2- GPI promoter activity. Paper-10417163.
Surrounding the PANDER transcriptional start site are several putative A- and E-Box elements that may bind to the various pancreatic transcriptional factors of MafA, BETA2/ NeuroD, and Pancreatic Duodenal Homeobox-1 ( PDX-1). Paper-13035886.
Markers that are currently widely used for the investigation of adult hippocampal neurogenesis are: glial fibrillary acidic protein, nestin, Pax6, NeuroD, PSA- NCAM, doublecortin, TUC-4, Tuj-1, and calretinin. Paper-13376352.
Affinity labeling and immunoprecipitation studies demonstrate that alpha 2-macroglobulin ( alpha 2M) is the major serum- binding protein for transforming growth factors beta 1 and beta 2 ( TGF-beta 1 and TGF-beta 2). Paper-6577237.
This synergistic activation by SREBP-1c/ BETA2/E47 was not mediated through SREs but through the E-boxes on which BETA2/E47 physically interacts with SREBP-1c, suggesting a novel function of SREBP as a co-activator. Paper-10973630.
Moreover, treatment with heparinase III impaired BETA2/ NeuroD internalization, whereas treatment with chondroitinase ABC, or with chondroitinase AC, was completely ineffective in inhibiting BETA2/ NeuroD internalization. Paper-12450083.
The CD18 hypomorphic (CD18hypo) PL/J mouse model clinically resembling human psoriasis is characterized by reduced expression of the common chain of beta2 integrins (CD11/ CD18) to only 2-16% of WT levels. Paper-12078773.
For example, the C-terminal extension of standard subunit beta2 is required for beta2's interaction with adjacent beta3, whereas the C-terminal extension of immunosubunit beta2i is dispensable for beta2i's interaction with beta3. Paper-13264816.
Integrin-linked kinase ( ILK), bound to the cytoplasmic tails of integrin beta1, beta2, and beta3, is thought to signal through AKT and glycogen synthase kinase-3beta (GSK-3beta) for survival and proliferation regulation. Paper-10518558.
To assess whether absolute levels of PKC were altered in human diabetes, platelet levels of PKC alpha, beta 1 and beta 2 were determined in 22 controls and 25 NIDDM subjects with poorly controlled diabetes (HbA1c = 9.8 +/- 0.36%). Paper-999191.
We have investigated the PRKAB2 gene encoding the beta2 subunit, which is located on chromosome 1q within a region linked with type 2 diabetes mellitus (T2DM) in the Pima Indians and four different Caucasian populations. Paper-9591629.
Similarly, denopamine exhibited a 7-fold greater potency to stimulate the adenylyl cyclase activity in cells expressing the beta-1 AR than in cells expressing the beta-2 subtype, which confirmed the subtype selectivity of this drug. Paper-7875831.
CONCLUSIONS: Our results allow us to conclude that the TGF-beta3 family of cytokines, particularly the isoforms beta-2 and beta-3, seem to play a key role in the initiation, progression and transformation of tumoral cells inprostatic ADC. Paper-10225010.
Expression of cytokeratin 1, 5, 14, 19 and transforming growth factors-beta1, beta2, beta3 in osteofibrous dysplasia and adamantinoma: A possible association of transforming growth factor-beta with basal cell phenotype promotion. Paper-8522241.
We describe a patient with clinical features compatible with a moderately severe phenotype of LAD-1 but who expresses the beta2 integrins lymphocyte function- associated molecule (LFA)-1 and Mac-1 at 40%-60% of normal levels. Paper-1719757.
The crystal structure of the Btk pleckstrin homology (PH) domain in complex with Ins(1,3,4,5)P(4) has shown that the binding site is located in a partially buried pocket between the beta 1/ beta 2- and beta 3/ beta 4-loops. Paper-8741425.
Activation of beta2 integrins in response to GPCR signals and intrinsic soluble ligand binding properties of the very late activation antigen-4 ( VLA-4) integrin are also retained in patient leukocytes. Paper-9728048.
These determinations are made by RNAse protection assay after 3 or 6 days of incubation and include measurements of the RNAs for type I collagen, alkaline phosphatase, osteopontin, transforming growth factor alpha 1 and beta 2, and Vgr-1/ BMP-6. Paper-809644.
Triggered via a beta-arrestin/ GPCR interaction, the motif must be displaced and must undergo a strand to helix transition to enable the beta2 appendage binding that drives GPCR- beta-arrestin complexes into clathrin coats. Paper-11323777.
A comparison between the structures of eotaxin-3 and related chemokines suggests that the electrostatic potential in the vicinity of a surface groove and the structure of the beta2- beta3 turn may be important for maintaining receptor specificity. Paper-8997718.
We have analyzed herein the ability of anti-CD43 monoclonal antibody (MoAb) to upregulate both beta 1 and beta 2 integrin- mediated cell adhesion and to promote redistribution of the CD43 molecule into a cellular uropod. Paper-344940.
We analyzed muscle for Na+-K+-ATPase alpha1, alpha2, alpha3, beta1, beta2, and beta3, as well for RNAP II, eIF-4E, and 4E-BP1 mRNA expression by real-time RT-PCR and Na+-K+-ATPase isoform protein abundance using immunoblotting. Paper-10817809.
The major findings are that the A-box sites that bind PDX-1 are among the most highly conserved regulatory sequences, and that the conservation of the C1, E1, and CRE sequences emphasize the importance of MafA, E47/ beta2, and cAMP-associated regulation. Paper-12333887.
Whereas NeuroD1 expression was higher in corticotroph and CNS adenomas (P=0.0001 versus Pit-1-dependent PA), Ngn2 expression was higher in secreting PA, especially in Pit-1-dependent PA (P=0.007 and P=0.0006 versus CNS respectively). Paper-13413155.
Furthermore, IL-8 receptors interacted with endogenous pertussis toxin-sensitive G proteins or with the recombinant G protein Gi to release free beta gamma subunits that could then specifically activate the beta 2 isoform of PLC. Paper-93609.
Transcription factor binding sites for STAT, CREB, C/EBPbeta, NF-1, AP-1, NFAT, HNF-3beta and HNF-1 have been identified in the promoter region of the beta2- GPI gene by computer analysis. Paper-12492968.
Genetic depletion of Trk receptors led to impaired recruitment of C/EBPs and NeuroD in vivo, and elimination of Cebpa and Cebpb alleles reduced BDNF induction of Fos, Egr1 and Egr2 in primary neurons. Paper-13113214.
In contrast, AML cell adhesion to BMF monolayers was not impaired by blocking antibodies to either beta 1 or beta 2 integrins used alone, although the combination of anti-CD11/ CD18 and anti-VLA-4 inhibited binding in more than 50% of cases. Paper-7601272.
CVAK104 is a novel coated vesicle- associated protein with a serine/ threonine kinase homology domain that was recently shown to phosphorylate the beta2-subunit of the adaptor protein (AP) complex AP2 in vitro. Paper-12243452.
The results strongly suggest that gp120 and the beta 2 region (amino acids 134-148) of HLA-DR1 bind mainly to the same part of CD4 domain 1 and that the CD4 binding site of HLA-DR requires the existence of a class II homodimer. Paper-221404.
RESULTS: Despite the negligible expression of IL-12R on fresh cells, PB CD4+ T cells from RA patients expressed higher levels of both IL-12Rbeta1 and beta2 subunits after stimulation with anti-CD3 antibody (Ab) than the cells of healthy controls. Paper-10265122.
Surprisingly, despite the homology between BETA2 and BETA3 and its intact basic region, BETA3 is unable to bind the insulin E box in bandshift analysis as a homodimer or as a heterodimer with the class A bHLH factors E12, E47, or BETA1. Paper-466182.
Finally, we find a striking congruence in the positions of amino acid residues found to be under positive selection in both TRIM5alpha and TRIM22, which in both proteins fall predominantly in the beta2- beta3 surface loop of the B30.2 domain. Paper-13459058.
Also, PDX-1 has potency to induce insulin-producing cells from non-beta-cells in various tissues, and PDX-1-VP16 fusion protein more efficiently induces insulin-producing cells, especially in the presence of NeuroD or Ngn3. Paper-13384945.
Co-transfection of beta2- GPI promoter-luciferase vector with HNF-1alpha expression vector in Huh7 and HNF-1-deficient HeLa cells demonstrated the transactivation effect of HNF-1alpha on beta2- GPI promoter activity. Paper-10417163.
Immunodetectable alpha1 and beta2 subunits of the Na/K-ATPase localized to the apical membrane of collecting duct cysts in tissue sections of human fetal ARPKD nephrectomy specimens and conditionally immortalized cells derived from these cysts. Paper-9816917.
Specifically, expression of the alpha2, alpha4, beta1, beta3, and gamma1 to gamma3 subunit mRNAs was significantly less in the OFC, whereas the expression of beta1, beta2, gamma1, and delta subunit mRNAs was less in the DLPFC of alcohol-treated monkeys. Paper-12324228.
The different population linkage disequilibrium relationships have permitted tentative assignment of TaqI fragments to either the DR beta 1 or DR beta 2 genes and are highly suggestive that the DQw1 specificity is encoded by the DQ alpha chain gene. Paper-5442991.
CONCLUSION: We here identify three IE genes as targets for BDNF/ TrkB signaling, show that C/EBPalpha and -beta are recruited along with NeuroD to target promoters, and that C/EBPs are essential mediators of Trk signaling in cortical neurons. Paper-13113214.
In the hippocampal sector CA3c and in the piriform cortex, mRNA levels of GABA(A) receptor subunits alpha1, alpha5, beta1, beta2, beta3, gamma2 and of both GABA(B) receptors declined (by 46-72%) after 5-16 days, being consistent with the extensive cell loss. Paper-9146276.
Adhesion studies under defined laminar flow conditions showed that the antioxidant treatment induced an enhanced adhesion mediated by beta2 integrins with a decrease in the fraction of PMN rolling on TNF-alpha-activated endothelial cells. Paper-1154406.
This observation is consistent with the previously described affinity of the beta 2 integrins for LPS, leading to the notion that the LPS portion of the LPS/LPB complex binds to Mo1, serving to link it with LPS/ LBP bound to CD14. Paper-1000927.
A secreted BSC-1 cell protein identical to transforming growth factor beta 2 inhibited DNA synthesis in growing cultures and induced marked accumulation of c-sis mRNA without a corresponding increase in the release of PDGF-like activity. Paper-5972453.
These data imply that only high affinity interactions between the integrin alpha4beta1 on melanoma cells and VCAM-1 on activated endothelial cells may enhance the metastatic capacity of human beta2/ beta3-negative melanoma cells. Paper-13271884.
In cell type-specific expression, KCNQ1 was expressed in most taste bud cells, including beta2/M5-TRCs, whereas KCNH2 was expressed in a subset of beta2/M5-TRCs with no correlation with their taste modality, such as sweet or bitter taste reception. Paper-12256203.
A robust and progressive rise in DNA methylation levels across the lifespan was observed for 8/50 loci ( GABRA2, GAD1, HOXA1, NEUROD1, NEUROD2, PGR, STK11, SYK) typically in conjunction with declining levels of the corresponding mRNAs. Paper-12499409.
Finally, mAb-mediated cross-linking of NKRP1A molecules in CD4+ T lymphocytes induced the up-regulation of the lymphocyte function- associated antigen 1 Mg(2+)- binding site as well as beta 1 and beta 2 integrin chains. Paper-1205374.
BACKGROUND: We investigated the possible role of antiphospholipid ( APA) and anti-human 2-glycoprotein I ( beta2- GPI) antibodies (Ab) in thrombosis and atherosclerosis in human immunodeficiency (HIV)-positive patients, in whom they seem to be more frequent. Paper-1442048.
Seven genes, including hepatocyte nuclear factor 4A ( HNF4A), glucokinase ( GCK), HNF1A, pancreas duodenal homeobox 1 ( PDX1), HNF1B, neurogenic differentiation 1 ( NEUROD1), and PAX4, were directly sequenced in all patients. Paper-13745354.
The derivatives that stably express the constitutively activated mutants of PKCbeta1 or beta2 also displayed increased cyclin D1 promoter activity in transient transfection luciferase reporter assays, and this induction of activity requires activator protein 1. Paper-12344927.
B19- associated aCL increased their binding to antigen in the presence of beta 2- GPI as a binding cofactor, similar to aCL found in SLE patients, but unlike antibodies from patients with other viral infections or from those with syphilis. Paper-868192.
PURPOSE: To determine whether the overexpression of the proteasome catalytic beta5 subunit ( PSMB5) can induce the expression of the catalytic subunits beta1 and beta2, enhance proteasome activity, and exert a cytoprotective effect in lens epithelial cells. Paper-12444702.
Fifty-one PAs--22 clinically non-secreting (CNS) and 29 secreting respectively--and normal human pituitaries (NP) were studied for NeuroD1 and neurogenins ( Ngn1, Ngn2 and Ngn3) gene expression by RT-PCR and quantitative real-time RT-PCR (qRT-PCR). Paper-13413155.
The beta-2 agonist salmeterol, the H1-receptor antagonist terfenadine and the phosphodiesterase inhibitor theophylline inhibited the release of IL-4 and IL-13 by more than 50% following 4 h of basophil stimulation with anti-IgE. Paper-1558032.
Serum alpha 1 antitrypsin, alpha 1 acid glycoprotein and beta 2 glycoprotein I concentrations were determined in 36 patients with malignant hepatocellularcarcinoma, 30 with cirrhosis and 35 with hepatitis by quantitative immunoelectrophoresis. Paper-3324187.
RESULTS: Although the pancreatic transcription factors Pdx1, Ngn3, NeuroD, and Pax6 were induced in both SHs and MHs after Adeno-Pdx1 gene expression, the pancreatic transcription factors Nkx2.2 and Nkx6.1 were induced in SHs more than in MHs. Paper-12960448.
We compared the expression of antigen 14C5 with the expression of eight integrin subunits ( alpha1, alpha2, alpha3, alphav, beta1, beta2, beta3, and beta4) and three integrin heterodimers (alphavbeta3, alphavbeta5, and alpha5beta1) by flow cytometry. Paper-13507331.
Heteromeric nAChRs generally contain either a beta2 or beta4 subunit in addition to an alpha subunit at the ligand- binding interface. alpha-Conotoxin BuIA kinetically distinguishes between beta2- and beta4-containing nAChRs, with long off times for the latter. Paper-12220223.
Levan ( beta-2, 6-fructan), a major fraction of fermented soybean mucilage, displays immunostimulating properties via Toll-like receptor 4 signalling: induction of interleukin-12 production and suppression of T-helper type 2 response and immunoglobulin E production. Paper-11362797.
Furthermore, inhibition of Src tyrosine kinases, or phosphoinositide 3-kinase with PP1 or LY294002, respectively, blocked beta2 integrin- induced degranulation and the redistribution of Rap1 and Rap2 to a membrane-enriched fraction. Paper-13049272.
Recombinantly expressed gamma-aminobutyric acid type A (GABAA) receptors consisting of alpha 1, beta 2, and gamma 2 subunits contain a binding site for benzodiazepines that differs in its properties from that of alpha 3 beta 2 gamma 2 receptors. Paper-7158898.
Since aminophylline stimulates the secretions of catecholamine from the sympathetic nerve endings and the adrenal medulla, we assumed that TRH was released from the hypothalamus by a beta-2-receptor mechanism because TSH secretion had been stimulated. Paper-6370291.
Anti-c-Myc monoclonal antibody (mAb 9-E10) derivatized with a fluorophore ( europium cryptate, EuK) was used to individually label c-Myc-tagged alpha1-, beta2-, or gamma2-subunits of the hetero-oligomeric gamma-aminobutyric acid (GABAA) receptor in intact cells. Paper-1812272.
In addition, multiple genes associated with vesicular trafficking and exocytotic machinery, including Sec24D, carboxypeptidase E, myosin Va, SNAP25, syntaxin 1A, Rab, Rims, Munc18-1, and adenylyl cyclase, were up-regulated by NeuroD gene transfer. Paper-12438830.
We report that in addition to CD21 and IgE, CD23 interacts specifically with the CD11b and CD11c, the alpha chains of the beta 2 integrin adhesion molecule complexes CD11b- CD18 and CD11c- CD18, on monocytes. Paper-300616.
We previously found that SNX9 is one of the major proteins in hematopoietic cells that binds to the alpha and beta2-appendages of adaptor protein complex 2 (AP-2), a protein with a critical role in the formation of clathrin-coated vesicles at the plasma membrane. Paper-10042725.
Unlike beta1- and beta2, beta3-immunoreactivity did not decrease after avulsion injury, and the beta3:neurofilament ratio was significantly increased in proximal injured human nerves. beta3-subunit expression may thus be regulated differently from beta1, beta2 and Nav1. Paper-10535604.
These hNPCs showed neurosphere formation, expressed high levels of early neuroectodermal markers, such as the proneural genes NeuroD1 and Olig2, the NSC markers Nestin and Musashi1, the proliferation marker Ki67 and significant activity of telomerase. Paper-12052638.
PMA-induced transcellular ISC correlated with PKC-alpha membrane association, whereas low doses of both agents inhibited transcellular and apical membrane ISC-cAMP, increased PKC-beta1, decreased PKC- beta2 membrane association, and caused reciprocal changes in isoform mass. Paper-12059877.
We show that while there are no changes in alpha1, alpha4, alphav, beta1, beta2, beta3, alpha5beta1, alphavbeta3, alphavbeta5 integrin expression on the LEC surface after hypoxia exposure, there exists an accumulation of TGFBI adaptor protein in LEC supernatants. Paper-12933540.
We identified two homozygous mutations in NEUROG3, both of which rendered the NEUROG3 protein unable to activate NEUROD1, a downstream target of NEUROG3, and compromised the ability of NEUROG3 to bind to an E-box element in the NEUROD1 promoter. Paper-12148931.
5. These cells also expressed the transcription factor, neurogenin-3, NeuroD/ beta 2, and islet factor I, which are believed to be transcription factors in neuroectoderm as well as in pancreatic islet cells, but not pancreatic-duodenal homeobox 1, Pax4, or Nkx2. Paper-8674118.
Glutathione S-transferase-beta2 tail fusion protein/ mutagenesis experiments suggest that the affinity of alpha-actinin binding to the beta2 tail is regulated by a change in the conformation of the tail that unmasks a cryptic alpha-actinin binding domain. Paper-1681278.
In this study, we define the scaffolding potential of the Schwann cell dystrophin glycoprotein complex (DGC) by establishing the presence of four syntrophin isoforms, ( alpha1, beta1, beta2, and gamma2), and one dystrobrevin isoform, (alpha-dystrobrevin-1), in the abaxonal membrane. Paper-12766886.
A monoclonal antibody specific for the insulin receptor ( MA5) completely immunoprecipitated all the insulin binding activity from both the alpha 2 beta 2 heterotetrameric and alpha beta heterodimeric insulin receptor complexes but did not immunoprecipitate IGF-1 receptors. Paper-6452853.
We hereby report several previously unknown DNA polymorphisms for HOXD8, BETA2, and IGFBP5, which we have used along with previously known polymorphisms of HOXD8 and CTLA4 to test whether these candidate loci are the susceptibility genes on chromosome 2q31-35. Paper-1027504.
RESULTS: Within the cohort, we found one patient with a novel mutation, R321H (CGC-->CAC) in exon 5 of the HNF-1alpha gene, one with ND1 mt3316 G-->A mutation in mitochondrial DNA, five with Ala45Thr polymorphisms in the neuroD1/ beta2 gene, and two patients with autoantibodies to SOX13. Paper-11363193.
By binding and transactivation studies, we found that Pax6 indirectly regulates PC2 gene transcription through cMaf and Beta2/ NeuroD1 while it activates the 7B2 gene both directly and indirectly through the same transcription factors, cMaf and Beta2/ NeuroD1. Paper-13686902.
Na(v)1.9 mRNA was detected at E19, reached a maximum at P1, and was then reduced. beta1 mRNA showed a steady rise in expression from E17, while beta2 mRNA was widely expressed from P1. beta 3 mRNA was detected at E15, reached a maximum at E19 followed by a decrease in expression. Paper-13744959.
Cytohesin-1 had been identified as a regulator of beta2 integrin inside-out regulation in immune cells and was subsequently shown to be involved in mitogen-associated protein kinase signaling in tumor cell proliferation as well as in T-helper cell activation and differentiation. Paper-13334813.
Density measurements of nine hippocampal regions demonstrated highest levels of beta2/3 immunolabeling in the inner molecular layer of the dentate gyrus > CA1 > CA2, while the lowest levels were found in the granular layer of the dentate gyrus < or = CA4 < CA3 field. Paper-1213773.
A point-mutated form of PC4 within the C-terminal domain beta-ridge, PC4 W89A, or a triple mutant in the beta2- beta3 loop of PC4, F77A/K78G/K80G, inactivate the ability of PC4 to bind AP-2alpha and to relieve the transcription self-interference of AP-2alpha. Paper-10062268.
Immunoblot analysis indicated that MCF-7 cells that stably overexpress wild-type or constitutively activated mutants of PKCbeta1 or beta2 had higher cellular levels of cyclin D1 than vector control cells, whereas cells that express a dominant negative mutant had decreased levels of cyclin D1. Paper-12344927.
Furthermore, transfection of HEK 293 cells with alpha 1 plus gamma 2L subunits results in responses to GABA that are potentiated by the drug loreclezole, suggesting that a subunit resembling the beta 2 or beta 3 subunit had assembled with the alpha 1 gamma 2L subunits. Paper-718958.
Their further differentiation into beta-like cells expressing genes related to endocrine pancreas development ( Ngn3, NeuroD, Pax4, Nkx2.2, Nkx6.1, Pdx-1) and beta-cell function ( Glut-2, Kir6.2, insulin) was achieved only in the presence of Pdx-1(-VP16) protein. Paper-13664165.
We have previously reported the presence in human gingival keratinocytes (GKC) of choline acetyltransferase, the acetylcholine (ACh) synthesizing enzyme, acetylcholinesterase, the ACh degrading enzyme, and alpha 3, alpha 5, alpha 7, beta 2 as well as alpha 9 nicotinic ACh receptor subunits. Paper-9686735.
The clathrin heavy chain accesses the same contact surface on the AP-2 beta2 appendage, but because of additional clathrin binding sites located within the unstructured hinge segment of the beta2 subunit, clathrin binds the beta2 chain with a higher apparent affinity than PIPKIgamma661. Paper-13760896.
BACKGROUND: Inhaled long-acting beta2 agonists improve lung function and health status in symptomatic chronic obstructive pulmonary disease ( COPD), whereas inhaled corticosteroids reduce the frequency of acute episodes of symptom exacerbation and delay deterioration in health status. Paper-9657386.
The expression of other basic helix-loop-helix genes changed during RA-induced differentiation: expression of neuroblast-specific ASCL1 ( HASH-1) gene was promptly reduced after RA treatment, whereas expression of differentiation-promoting genes NEUROD6 (NEX-1, HATH-2) and NEUROD1 was increased. Paper-9165813.
Untreated and interleukin 1 ( IL-1) -pretreated confluent monolayers were overlaid with unstimulated and phorbol ester (PMA)- stimulated PMNs in the absence and presence of the monoclonal antibody IB4 recognizing and functionally blocking beta 2 ( CD18) of the leukocyte integrins. Paper-7212688.
We sequenced genes with a recognized role in monogenic forms of diabetes, including KCNJ11, ABCC8, GCK, IPF1, HNF1beta, NeuroD1 and TCF7L2, as well as a novel candidate gene, HNF6, known to be involved in hepatobiliary and pancreatic development, but did not identify mutations. Paper-12845006.
METHODS: We detected NeuroD1 gene expression, by duplex reverse transcriptase-polymerase chain reaction, in primary human prostate fibroblasts, in EPN, LNCaP, DU145, and PC3 cell lines before and after cAMP exposure, in 6 BPH and 11 pCA samples. Paper-12564061.
Insulin receptor beta subunit autophosphorylation occurs in an intramolecular trans-reaction in which one beta subunit phosphorylates the adjacent beta subunit within an alpha 2 beta 2 holoreceptor complex (Frattali, A. L., Treadway, J. L., and Pessin, J. E. (1992) J. Biol. Chem. 267, 19521-19528). Paper-7780805.
Therefore, the present study has investigated the ability of beta2-mu-free HLA class I heavy chains to modulate NK cell- mediated lysis of melanoma cells and to present melanoma-associated antigen (MAA)-derived peptides to HLA class I-restricted, MAA-specific cytotoxic T lymphocytes (CTL). Paper-1574919.
Using indirect immunofluorescence and flow cytometry, we found that both beta 1 and beta 3 integrin subunits were expressed on the surface of HTR trophoblast cells adhering to entactin; in contrast, beta 2 and beta 4 integrin subunits were not detected. Paper-845170.
Finally, using an in vitro assay, we demonstrate that Ngn2 and ND1 equally and exclusively direct differentiation of Mash1- expressing precursors into calbindin- expressing and calretinin-expressing neurons, which are both neuronal subtypes normally found in the olfactory bulb. Paper-13606408.
We analyzed expression of human NEUROD1, NEUROD2, NEUROD3, and ACHAETE SCUTE 1 ( HASH1) in cerebellar and cerebral primitive neuroectodermal tumors ( PNETs), gliomas, and cell lines derived from a variety of neuroectodermal tumors by Northern analysis and in situ hybridization. Paper-1127296.
Four microsomal cytochrome P-450s ( P-450), all of which are active testosterone 6 beta-hydroxylases, were purified to electrophoretic homogeneity from livers of phenobarbital-treated (P-4506 beta-1 and P-4506 beta-3) or dexamethasone-treated adult male rats (P-4506 beta-2 and P-4506 beta-4). Paper-17489.
In patients A, B, C, and D with homozygous mutations in NeuroD1, CS1 ( normal range, 6.8 to 18.5 ng/mL/min) was 0.508, 1.481, 1.223, and 1.584 ng/mL/min, respectively, and Si ( normal range, 2.6 to 7.6 x 10(-4)/min/[microU/mL]) was 0.727, 3.31, 3.79, and 0.00 x 10(-4)/min/(microU/mL), respectively. Paper-9541118.
These results showed that Pyk2 is involved in the functional activation of granulocytic cells in 2 signaling pathways: an fMLP receptor- mediated "inside-out" signaling pathway that might cause beta2 integrin activation and a subsequent beta2 integrin-mediated "outside-in" signaling pathway. Paper-8380371.
Sequence analysis of the catalytic domains of the PHDs in the light of crystal structures for PHD2, and results for other 2OG oxygenases, suggested that either the C-terminal region or a loop linking two beta-strands ( beta2 and beta3 in human PHD2) are important in determining substrate selectivity. Paper-12734926.
After completion of deletion construct analysis and mutagenesis and mobility shift assays, we concluded that collapsin response mediator protein-2 basal promoter activity is regulated by the transcription factors AP-2 and Pax-3, whereas E2F, Sp1 and NeuroD1 seem not to participate in its regulation. Paper-12428366.
In previous work (Sankaran, B., Osterhout, J., Wu, D., and Smrcka, A. V. (1998) J. Biol. Chem. 273, 7148-7154), we showed that overlapping peptides, N20K (Asn(564)-Lys(583)) and E20K (Glu(574)-Lys(593)), from the catalytic domain of phospholipase C (PLC) beta2 block Gbetagamma-dependent activation of PLC beta2. Paper-8775751.
We show that upon neutrophil adhesion to the endothelial lining, leukocytic beta2 integrin signaling triggers the release of neutrophil-borne heparin-binding protein ( HBP), also known as CAP37/azurocidin, a member of the serprocidin family of neutrophil cationic proteins. Paper-9076284.
Our data show that all PPAR-gamma agonists under study significantly down-regulated the RSV- induced expression of ICAM-1 on A549- and NHBE cells in a dose-dependent manner resulting in a reduced beta2 integrin-mediated adhesion of monocytic effector cells (U937) to RSV-infected A549 cell monolayers. Paper-13178570.
TCF-I beta 1 was slightly neutralized by anti-TNF alpha antibody, but TCF-I beta 2 was not affected by antisera against IL-1 alpha and IL-1 beta, or anti-TNF alpha antibody, thus ruling out the possibility that tumor necrosis factor ( TNF alpha) might be involved in tumor cell killing mediated by TCF-I beta 2. Paper-6289697.
A battery of antibodies directed against fragments of different connexins localized beta 1- and beta 2-gap junction antigens (connexins 32 and 26, respectively) at the intercellular borders of the superficial epithelium while alpha 1-gap junction antigen ( connexin 43) was localized to the loose connective tissues. Paper-215202.
In this anatomical study, we systematically investigated the co-expression of GAD67 with different nAChR subunits by using double in situ hybridization with a digoxigenin-labeled GAD67 probe and (35)S-labeled probes for nAChR subunits (alpha2, alpha3, alpha4, alpha5, alpha6, alpha7, beta2, beta3, and beta4). Paper-13014017.
The scheme has equivalent residues in the C'/C'' loop-C'' strand-C''/D loop region in domain 1 of CD4 and CD8 alpha binding to equivalent residues in the C and D beta-strands and C/D loops in HLA-DR beta 2 (class II) and HLA-A2 alpha 3 (class I) respectively through a series of electrostatic, hydrogen and hydrophobic bonds. Paper-7397443.
The effects of interferons (IFN)-alpha, beta 2 and -gamma in inducing megakaryocytic differentiation of blast cells from a patient with acute megakaryoblastic leukaemia (AMegL) was investigated in liquid suspension culture by the increase in CD41 and CD42b expressions using monoclonal antibodies in the APAAP technique. Paper-206899.
Northern blot analysis indicated a 3.4-kb RNA transcript for the beta 2 subunit, a 4.5-kb RNA for the alpha 1 subunit and a doublet of 2.3 and 2.6 kb for the beta 1 subunit, respectively. alpha 1 ( 100 kDa), beta 1 (45 kDa) and beta 2 (65 kDa) isoforms were detected in hRPE extracts by immunoblotting. Paper-796066.
Statistical comparison of the functional constraints imposed on the canonical and non-canonical PBC containing sequences reveals that a key arginine, which coordinates with the cAMP phosphate, has co-evolved with a glycine in a distal beta2- beta3 loop that allosterically couples cAMP binding to distal regulatory sites. Paper-13453834.
In contrast to control mice, transgenic mice with low-level beta2* nAChR expression in the VTA showed no increase in overall levels of cyclic AMP response element- binding protein ( CREB) but did show an increase in CREB phosphorylation in response to exposure to a nicotine-paired chamber. Paper-13728550.
In ADPKD kidneys, alpha1 and beta2 subunits were localized to the apical epithelial cell membranes, whereas beta1 was distributed throughout the cytoplasm and predominantly in the endoplasmic reticulum, but was not seen associated with cystic epithelial cell membranes or in cell membrane fractions. Paper-2085017.
Using a modification of the chromosome conformation capture (3C) assay in vitro and in ss cells, we observed that Pdx1 and BETA2/ NeuroD1 mediate looping of a segment of the insulin gene that brings EcoRI sites located at -623 bp and +761 bp (relative to the transcriptional start site) in proximity to one another. Paper-12772870.
We have examined, using immunohistological methods, the expression of the VLA (very late activation) family comprising beta 1 in association with alpha 1-6, and also alpha 6 in association with beta 4, the LFA beta chain beta 2, and the vitronectin receptor, in association with beta 1 or beta 5 and as the complex alpha v beta 3. Paper-6873399.
Furthermore, ISV markedly changes the gene expression profile of key insulin regulatory genes GLUT2, Ins1, Ins2, Pdx1/ Ipf1, Beta2/ Neurod1, Pax6 and 11-beta-HSD-1 and beta-cell transcription factors Nkx2-2, Nkx6-1, C/EBPalpha and FoxA2 in isolated islets of the KKAy mice. Paper-13018265.
In addition, they expressed multiple genes related to pancreatic beta-cell development and function (e.g. insulin 1, insulin 2, islet-1, Pdx-1, NeuroD/ beta2, glut-2 and Nkx6.1), but not other pancreas-specific hormones and enzymes (e.g. glucagon, somatostatin and amylase). Paper-13575761.
We found that Alx3 transactivates the insulin promoter by acting on the E2A3/4 enhancer in conjunction with the basic helix-loop-helix transcription factors E47/ Pan1 and Beta2/ NeuroD, and that Alx3 physically interacts via the homeodomain with E47/ Pan1 but not with Beta2/ NeuroD. Paper-12289834.
A more promising gene therapy approach has been to express pancreatic endocrine developmental factors, such as PDX-1, NeuroD/ BETA2 and Neurogenin 3, to promote differentiation of non-endocrine cells towards a beta cell or islet phenotype, enabling these cells to synthesize and secrete insulin in a glucose-regulated manner. Paper-11332468.
The association of a common T/C polymorphism in the promoter region of the beta 2 constant chain of the T-cell receptor with autoimmune diseases, such as insulin-dependent diabetes, autoimmune hepatitis, IgA nephropathy, membranous nephropathy, Graves' disease and Hashimoto's thyroiditis, was described in the 1990s. Paper-12763219.
Scatchard analyses of insulin binding to the alpha 2 beta 2 heterotetrameric control or dithiothreitol-treated but nondissociated alpha 2 beta 2 heterotetrameric insulin receptor complexes demonstrated a curvilinear binding isotherm with a maximum of 1 mol of insulin bound/ mol of alpha 2 beta 2 heterotetrameric complex. Paper-5728594.
We have previously reported that human T cell receptors (TcR) selected in the class II-restricted (HLA-DRB1*1302) response to a tetanus toxin peptide (tt830-843) frequently used the V beta 2 germ-line segment which paired with several V alpha segments and that the putative CDR3 of both alpha and beta chains showed remarkable heterogeneity. Paper-107043.
Cry1 induction at night was associated with up-regulation of genes coding for NeuroD1 ( neurogenic differentiation factor 1), Pbef / Nampt ( nicotinamide phosphoribosyltransferase), Hif1alpha (hypoxia-inducible factor-1alpha), and Kcnq5 (K+ channel) and down-regulation of Rorbeta, a key clock gene regulator. Paper-13047241.
The proposed model for the coordinate regulation of genes in the cluster accounts for the head-to-head orientation and parallel expression of the alpha1 and beta2 subunit genes, and for the disruption of transcription caused by insertion of a neomycin gene in the close vicinity of the alpha6 gene, which is proximal to a putative critical S/ MAR. Paper-13358658.
A role for Vav in the activation of p21ras is supported by the observations that antibody- induced engagement of beta 2 integrins causes an association of Vav with p21ras and that the effect of genistein on p21ras activation coincided with its ability to inhibit both the tyrosine phosphorylation of Vav and the Vav-p21ras association. Paper-619220.
We found that all the alpha subunits of the Gq class, including G alpha q, G alpha 11, G alpha 14, G alpha 15, and G alpha 16 could activate PLC beta 4 and that none of the G beta gamma subunits that we tested including G beta 1 gamma 1, G beta 1 gamma 2, G beta 1 gamma 3, or G beta 2 gamma 2 activated phospholipase C beta 4. Paper-8002556.
Monoclonal antibodies to the leukocyte response integrin (LRI) and the integrin-associated protein blocked entactin- mediated adhesion and chemotaxis whereas monoclonal antibodies to beta 1 and beta 2 integrins had no effect and PMN from an individual with leukocyte-adhesion deficiency adhered normally to entactin-coated surfaces. Paper-7450718.
We examined the association of variants in genes encoding several transcription factors ( TCF1, TCF2, HNF4A, ISL1, IPF1, NEUROG3, PAX6, NKX2-2, NKX6-1, and NEUROD1) and genes encoding the ATP-sensitive K(+) channel subunits Kir6.2 ( KCNJ11) and SUR1 ( ABCC8) with type 2 diabetes in a Japanese cohort of 2,834 subjects. Paper-12157432.
Some cells were cultured at 37 degrees C and 5% CO(2) in neurogenic or myogenic medium and analysed by immunocytochemistry, using Neuron specific enolase, Vimentin, Glial fibrillary acidic protein, Tau, MAP2 to confirm neurogenic differentiation, MyoD1, Myosin heavy chain, Actin smooth muscle, vimentin to confirm myogenic differentiation. Paper-13113235.
Out of 13 bHLH genes tested, 4 genes, i.e., achaete-scute complex-like 1 ( ASCL1, HASH1, Mash1), atonal homolog 1 ( ATOH1, HATH1, MATH1), NEUROD4 ( ATH-3, Atoh3, MATH-3) and neurogenic differentiation factor 1 ( NEUROD1, NEUROD, BETA2), showed differential expression among lung tumors and absent or low expression in normal lung. Paper-13274991.
In situ hybridization data supported the finding of SS4(+81) and SS2(+174) in vascular smooth muscle and trigeminal ganglion. beta-subunits beta2 and beta4 showed high expression in brain and trigeminal ganglion and some in cerebral vessels while beta1 showed highest expression in blood vessels. beta3 was found only in testis and possibly brain. Paper-13605684.
Amongst these factors, Pdx1 plays a critical role in defining the region of the primitive gut that will form the pancreas, Ngn3 expression drives cells towards an endocrine lineage, and a number of additional proteins including Pdx1, in a second wave of expression, Pax4, NeuroD1/ beta2, and MafA act as beta cell differentiation factors. Paper-13048514.
Those sets were a voltage-dependent K(+) channel series (rat erg, KvLQT1, Kv4.3, Kv4.2, Kv2.1, Kv1.5, Kv1.4, Kv1.2), an inwardly rectifying K(+) channel series (rat Kir6.2, SUR2A/B, Kir3.4, Kir3.1, Kir2.2, Kir2.1), and an inward cationic ion channel series (rat SCN5A, alpha1C, beta2, alpha2delta2 of cardiac L-type Ca(2+) channel and alpha1G). Paper-12273701.
MODY is both clinically and genetically heterogeneous, with six different genes identified to date; glucokinase ( GCK), hepatocyte nuclear factor-1 alpha ( HNF1A, or TCF1), hepatocyte nuclear factor-4 alpha ( HNF4A), insulin promoter factor-1 ( IPF1 or PDX1), hepatocyte nuclear factor-1 beta ( HNF1B or TCF2), and neurogenic differentiation 1 ( NEUROD1). Paper-12200832.
These synonyms are used for gene NEUROD1 (neurogenic differentiation 1): Neurogenic differentiation factor 1, NeuroD1, NEUROD, NeuroD, bHLHa3, BHF-1, BETA2.
These accession numbers are used for gene NEUROD1: Q9UEC8 (UNIPROT__AC), Q5U095 (UNIPROT__AC), AAH09046 (NCBI_GENBANK__AC), AAA93480 (NCBI_GENBANK__AC).
NEUROD1 is a homologue of NEUROD1 (neurogenic differentiation 1) from Bos taurus.
NEUROD1 is a homologue of NEUROD1 (neurogenic differentiation 1) from Pan troglodytes.
NEUROD1 is a homologue of NEUROD1 (neurogenic differentiation 1) from Gallus gallus.
NEUROD1 is a homologue of NEUROD1 (neurogenic differentiation 1) from Canis lupus familiaris.
NEUROD1 is a homologue of Neurod1 (neurogenic differentiation 1) from Mus musculus.
NEUROD1 is a homologue of Neurod1 (neurogenic differentiation 1) from Rattus norvegicus.
NEUROD1 is a homologue of neurod (neurogenic differentiation) from Danio rerio.
NEUROD1 is a homologue of cnd-1 (Neuro D homolog) from Caenorhabditis elegans.
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