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Is there anything for NOS to SNO in the Antarctic? Paper-12252710.
Arg II coimmunoprecipited with NOS1 but not NOS3. Paper-11369523.
In the GCL, amacrine cells but not RGCs were nNOS(+). Paper-10752899.
Additionally, TLR4 expression was reduced by NOS inhibitor. Paper-12987626.
No mutation in the CACNA1A and NOS genes was found in CH patients. Paper-11454333.
NOS1 decreased by 35.6% in group DI and increased by 58.1% in group DIS. Paper-10658433.
NOS1 C5266T and NOS3 G894T were not associated with asthma, atopy or FeNO. Paper-11090168.
The effect of HSP90 is mediated by the enhancement of CaM binding to nNOS. Paper-9090071.
Endothelin regulates NOS1 and NOS3 isoforms in the renal medulla. Paper-12602849.
Dystrophin antisense oligonucleotides decrease expression of nNOS in human neurons. Paper-10088009.
A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. Paper-12023390.
The NOS1 intron 2 GT repeat and STAT6 exon 1 GT repeat were associated with asthma. Paper-10224072.
PTCL/ NOS also show variable Ki-67 marking, with rates >80% heralding a worse prognosis. Paper-13057188.
PMCA is of particular interest since it may affect activity of calcineurin and nNOS. Paper-11374033.
One of these proteins, PSD-93, co-localizes with a subpopulation of nNOS in the macula densa. Paper-2141362.
NOS inhibition may have negative effects on CBF but further studies are required. Paper-10755582.
Expression of nNOS in these neurons was highly co-localized with p21ras and p16INK4a. Paper-2100638.
In CC, iNOS and nNOS decreased at 1 year, whereas there was no change in TGF-beta1 levels. Paper-13411466.
Moreover, the NOS inhibitor NMA partially reduced the angiogenic activity of icariin. Paper-13038985.
Endothelial NOS was evenly expressed in all groups while neuronal NOS was undetectable. Paper-8854537.
CaM-K Ialpha and CaM-K IV failed to phosphorylate nNOS at Ser(847) in transfected cells. Paper-9740553.
Effects of long term NOS inhibition on disease and the immune system in MOG induced EAE. Paper-11525933.
Conversely, N(G)-monomethyl-L-arginine, a NOS inhibitor, decreased PPARgamma binding. Paper-13134311.
These data demonstrate that the neuronal NOS is implicated in proliferative effect evoked by CCK. Paper-8297061.
No association was found between the estrogen or progesterone receptor status and nNOS expression. Paper-8623674.
Finally, the inhibition of TRPV1 receptor by capsazepine caused a significant fall in NOS activity. Paper-12970136.
Other studies reported that smoking modified the risk of PD due to polymorphisms in the MAO-B and nNOS genes. Paper-11140464.
We therefore studied wild-type mice and mice with a congenital deficiency of NOS 1, NOS 2, or NOS 3. Paper-8626798.
Microsatellite markers NOS1B ( NOS1), D7S636 (NOS3) and CPHD1-1/2 ( EDN-1) were genotyped in the sample. Paper-8607626.
Effects of acute caffeine administration on NOS and Bax/ Bcl2 expression in the myocardium of rat. Paper-12746250.
The expression of CD34, CD105, NOS and HIF-1alpha was detected by immunohistochemistry (S-P). Paper-12088072.
However, in the caudal brain, increased iNOS expression did not profoundly suppress nNOS expression. Paper-12721161.
NOS1 polymorphism is associated with atopy but not exhaled nitric oxide levels in healthy children. Paper-9994185.
NOS inhibitors that bound tightly to CLL cell NOS1 and were hydrophobic potently induced CLL cell death. Paper-12788601.
The infiltrate in the dermis contained numerous cells expressing AQP1, AQP3, nNOS, iNOS, and eNOS. Paper-10120685.
Thus, we conclude that a decrease of dystrophin in human neurons is associated with a decrease of nNOS expression. Paper-10088009.
However, EPO augmented urinary NOx concentrations as well as the expression of NOS 1 and NOS 2 in the kidney. Paper-12789179.
EGF- induced formation of the nNOS- RSK1 complex was significantly decreased by PD98059 treatment. Paper-12378501.
Neither eNOS nor nNOS expression was associated with vascular density, tumor grade or the TNM status of the tumors. Paper-8623674.
In NPY(-/-) mice, there were significantly fewer nNOS-containing enteric neurons compared with wild-type (WT) mice. Paper-12263095.
NOS inhibitors and SOD mimetic also prevent O(2)- induced diminished brain mass and functional deficit. Paper-12298011.
NOS inhibition had no effect on the augmented dilation during exogenous VIP or hyperthermia (P > 0.05). Paper-11509554.
NMDAR- nNOS generated zinc recruits PKCgamma to the HINT1-RGS17 complex bound to the C terminus of Mu-opioid receptors. Paper-12975238.
In OA chondrocytes NMDAR signalling requires extracellular calcium, association with PSD-95, and nNOS activity. Paper-13078653.
The results demonstrate that the nNOS variants are found at similar frequencies in MDD patients and healthy control subjects. Paper-9718307.
PRMT1 is the major type 1 PRMT in vivo, thus it is the primary producer of the competitive NOS inhibitor, ADMA. Paper-13008624.
The NOS inhibitor N(G)-nitro-l-arginine methyl ester (l-NAME) abolished the effect of eNOS transfection. Paper-12307235.
AT1 receptor blockade prevents the decrease in conduit artery flow- mediated dilatation during NOS inhibition in humans. Paper-13131557.
Sildenafil reduces cardiovascular remodeling associated with hypertensive cardiomyopathy in NOS inhibitor-treated rats. Paper-12151357.
In addition, the similar behavior of nNOS and SIN-1 provides further evidence for NO as initial product of the NOS reaction. Paper-12146329.
Conversely, overexpression of neuronal NOS within the PVN with adenoviral gene transfer significantly attenuated ANG II responses. Paper-11328121.
We therefore studied hemodynamic NOS and Bax/ Bcl2 expression in the rat myocardium after a single cafffeine administration. Paper-12746250.
Neuronal NOS ( nNOS) was expressed in normal (fetal and adult) human pituitary tissues and in GH-secreting adenomas. Paper-11051699.
In contrast, the expression of nNOS and eNOS gradually decreased in the hippocampal CA1 sector up to 14 days after ischemia. Paper-10531592.
The C415H mutant contained bound FAD and FMN at levels of 1.0 +/- 0.1 and 0.9 +/- 0.1 mol/ mol of nNOS subunit, respectively. Paper-587619.
In a population-based association study, we tested the hypothesis that the nNOS C276T polymorphism confers susceptibility to MDD. Paper-9718307.
In patients with COPD, neuronal NOS expression correlated negatively with the degree of the airway obstruction (%FEV1 predicted). Paper-10056023.
In rat islets, NOS inhibition decreased JNK and p38 activities induced by a 6-h exposure to IL-1beta. Paper-11103078.
Real-time PCR analysis of IFN-gamma-treated HMC1 showed a significant (P < 0.05) time-dependent increase in NOS1 and NOS3 mRNA. Paper-12688358.
NOS exists in three distinct isoforms: neuronal NOS ( nNOS), inducible NOS ( iNOS), and endothelial NOS ( eNOS). Paper-10326365.
The aim of this study was to determine whether allelic variation at the nNOS gene locus is associated with MS in an Australian cohort. Paper-10373114.
Here, we describe a novel interaction between the PDZ domain of nNOS and Vac14, the activator of the PtdIns(3)P 5-kinase PIKfyve. Paper-12360222.
CONCLUSIONS: Changes in muscle blood flow may affect the muscular size through actions of HSP-72, myostatin, and NOS-1. Paper-10739631.
Also, specific immunoreactivity for neurotransmitters SP, VIP, CGRP, ChAT and nNOS was mainly expressed by macrophagic cells. Paper-12043436.
Renin, NO synthase-1 ( NOS-1), and cyclooxygenase-2 ( COX-2) are key regulators of the RAS and TGF. Paper-12654979.
This NOS is regulated by its substrate L-arginine, by calcium, and by phosphorylation via PI3 kinase. Paper-11774975.
CONCLUSIONS: These data suggest a possible link between the NOS1 gene locus and the rate of decline in lung function in patients with CF. Paper-10361487.
The PSD95- nNOS interface: a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death. Paper-10742331.
Cellular compartmentalization of phosphorylated eIF2alpha and neuronal NOS in human temporal lobe epilepsy with hippocampal sclerosis. Paper-9693607.
Similarly, both myogenin (P = 0.001) and MyoD1 (P < 0.001) had significantly higher expression for ARMS than RMS, not otherwise specified ( NOS). Paper-12070991.
Moreover, a NOS inhibitor abolished MAPK phosphorylation as well as neurite outgrowth in genipin-treated cells. Paper-12734487.
Moreover, NOS inhibitor ( L-NAME) and anti-TLR 4mAb reduced the LPS-induced NO, IL-8 and VEGF production and ICAM-1 expression. Paper-12987626.
All NOS isoforms were expressed and active in unlesioned animals. nNOS and iNOS were detected in some small cells in the parenchyma. Paper-12243579.
Both EFS and LS led to fluorescence emission from a fiber network associated with neuronal NO synthase ( nNOS) immunoreactive nerves. Paper-12655790.
Thus these studies provide direct evidence demonstrating that HSP90 enhances nNOS catalytic function in vitro and in intact cells. Paper-9090071.
This study investigated the expression of NO synthases ( NOS) and their relationship with expression of ET-1 and angiogenic markers in PTC. Paper-12014329.
The presence of L-NAME, an inhibitor of NOS, abrogated the inhibitory effect of ammonia on PRL secretion from APs from control and PH rats. Paper-12418269.
Topical application of dynorphin A (1-17) antiserum significantly attenuated neuronal NOS up-regulation in the adjacent T9 and T12 segments. Paper-11838826.
The expression of nitric oxide synthase-1 ( NOS-1) mRNA increased (P < 0.01), whereas that of IGF-1 mRNA showed no significant change (P = 0.36). Paper-10739631.
Thus, NO binding to the NOS heme may be a fundamental feature of catalysis and functions to down-regulate NO synthesis by neuronal NOS. Paper-369203.
Immunoreactivities for VAChT and nNOS, VAChT and VIP, and nNOS and VIP, were generally found in the same varicose nerve terminals. Paper-8420466.
This occurred in the absence of modifications in NFH, NFM or neuronal nitric oxide synthase (Type I NOS; nNOS) steady state mRNA levels. Paper-2029557.
In addition to NOS-1-positive reactions, COX-2-positive reactions were observed in the MD of mice, rats, hamsters and gerbils. Paper-12654979.
Recent studies have shown that antioxidants and selective neuronal NOS inhibitor increase survival in the SOD1 transgenic mouse model of FALS. Paper-2118071.
Diabetic rat studies suggest that skeletal muscle neuronal NOS ( nNOS) micro protein expression may be reduced in human insulin resistance. Paper-12502594.
To test whether variants of NOS1, NOS2, and NOS3 relate to asthma, a genetic association study was conducted in a British population (n = 300). Paper-2121910.
The presence of nNOS and DDAH1 in brain suggests that ADMA may have specific CNS activity and be more than an unregulated metabolite. Paper-13399466.
We examined the relationship between the size of an AAT repeat polymorphism in intron 20 of the NOS1 gene and FENO in 75 patients with CF. Paper-8551324.
In building our recombinant system, we used human kidney embryonic cells, HEK 293, as host for transfection of nNOS and NMDA receptor proteins. Paper-9491874.
PCA therefore not only increases the expression of nNOS but also induces the expression of iNOS and NT in both neurones and astrocytes. Paper-12302754.
We conclude that mitochondrial Arg II negatively regulates NOS1 activity, most likely by limiting substrate availability in its microdomain. Paper-11369523.
The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ domains of beta2-syntrophin and nNOS in pancreatic beta-cells. Paper-8563994.
Furthermore, L-NAME, a non-selective NOS inhibitor and methylene blue, a guanylate cyclase inhibitor blocked the effect of sildenafil. Paper-12145672.
Northern blot analysis revealed that DAN mRNA was detected in OS-KH and RMS-NK cells, but was not detectable in SAOS-2, NOS-1, and ASPS-KY cells. Paper-8612720.
Such genes include those for monoamine oxidase ( MAO-A isoform), nitric oxide synthase ( nNOS isoform) and the peripheral-type benzodiazepine receptor. Paper-10126564.
Renoprotective effects of neuronal NOS-derived nitric oxide and cyclooxygenase-2 metabolites in transgenic rats with inducible malignant hypertension. Paper-12684290.
These data demonstrate that the FMN subdomain of CYPOR cannot effectively substitute for that of nNOS, whereas the FAD subdomains are interchangeable. Paper-9777495.
Although pre-incubation with AM251 (CB1 antagonist) or AM630 ( CB2 antagonist) had no effect, co-incubation with both antagonists induced NOS activity. Paper-12970136.
Immunohistochemical double labeling for nNOS and SP or enkephalin further confirmed that nNOS is found in boutonal and cap-like endings in the CG. Paper-2044486.
Thus, we attempted to study whether or not a decrease of dystrophin expression would induce a modification in nNOS expression in cultured human neurons. Paper-10088009.
Purified MV showed lower ecNOS (14-fold), COX-1 (2-fold), and about equal levels of bNOS and COX-2 in comparison with MV from 6-week-old pigs. Paper-1947703.
Serum TNF-alpha, sTNFR-I, and asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NOS, in CD were significantly higher than in UD or NS. Paper-11626063.
ICA512 also interacted in vitro with the PDZ domain of nNOS and ICA512- nNOS complexes were co-immunoprecipitated from INS-1 cells. Paper-8563994.
Confocal and biochemical analysis confirmed subcellular co-localisation and protein-protein interaction of RyR1 with nitric oxide (NO)-synthase type-1 ( NOS1). Paper-12765175.
Resveratrol exerts its antiproliferative effect on HepG2 hepatocellular carcinoma cells, by inducing cell cycle arrest, and NOS activation. Paper-12304474.
Associations between ACS and the AAT repeat in intron 13 (formerly intron 20) of the NOS1, and with NOS3 T-786C polymorphism were explored. Paper-13163808.
The addition of inhibitors of Hsp90, phosphatidylinositol 3-kinase, and NOS significantly alleviated this hypoxia-induced attenuation of respiration. Paper-13093277.
Water-soluble heteroatomic basic classes detected at >1% relative abundance include N, NO, NO2, NS, NS2, NOS, NO2S, N2, N2O, N2O2, OS, O2S, and O2S2. Paper-13265698.
CONCLUSIONS: DDAH2 upregulated the expression of VEGF through Sp1-dependent and NO/ NOS system-independent promoter activation. Paper-12046531.
Patients with CF who had the NOS1 genotype associated with high NO production had a slower decline in lung function during the 5 year follow up period. Paper-10361487.
In vitro, we determined NOS and soluble guanylate cyclase (sGC) expression, NOS activity, and haemoxygenase ( HO) expression in the lung. Paper-12676463.
To study this, human MSCs were stimulated to produce growth factors with TNF or LPS with and without various doses of NO donors or NOS inhibitors. Paper-13044119.
Two cases classified as nonkeratinizing SQCC and 2 cases of large cell neuroendocrine carcinoma on histology were misclassified as ADC- NOS by FNA. Paper-13394845.
Immunohistochemistry studies were performed for the detection of cGMP and nNOS, while Western blot analysis was employed for the detection of SHP-1. Paper-11363473.
As classic neurotransmitters, VIP is stored in vesicles in the nerve endings, while NO is synthetized on demand by the neuronal isoform of NO synthase ( nNOS). Paper-10536889.
The expression of NHE3, NBC1, nNOS and iNOS proteins was determined in the cortex of the kidney by immunoblotting and immunohistochemistry. Paper-12752771.
To date, 3 distinct NOS isoforms have been identified: neuronal NOS ( NOS1), inducible NOS ( NOS2), and endothelial NOS ( NOS3). Paper-11281116.
These results demonstrate that E2-stimulated NO production occurs via estrogen receptor-mediated activation of the constitutive NOSs, neuronal NOS and eNOS. Paper-10611477.
In mice, Meis2-expressing ( Meis2+) AM cells are not cholinergic or dopaminergic, but some are immunoreactive for neuronal nitric oxide synthase ( bNOS). Paper-13419718.
It is established that neuronal NO synthase ( nNOS) is associated with the chaperone hsp90, although the functional role for this interaction has not been defined. Paper-9163703.
The administration of AST-120 to CRF rats significantly increased urine levels of NOx and the expression of glomerular eNOS and tubulointerstitial nNOS. Paper-12665123.
These data provide evidence that the NOS1 gene is not only associated with the variability of FENO, but also with P. aeruginosa colonization of airways in CF patients. Paper-8551324.
The syntrophins are PDZ-domain-containing proteins that facilitate the recruitment of signalling proteins such as nNOS (neuronal nitric oxide synthase) to the DPC [4]. Paper-8634394.
Activation of ERbeta increases levels of phosphorylated nNOS and NO production through a Src/ PI3K/Akt-dependent pathway in hypothalamic neurons. Paper-12994725.
In addition, six genes ( DPYSL2, DTNBP1, G30/ G72, GRID1, GRM4, and NOS1) showed overlapping suggestive evidence of association in both disorders. Paper-11451435.
Furthermore, isorhynchophylline increased the NO content and NOS activity, and suppressed Ang II-induced over-expression of c-fos, OPN and PCNA. Paper-13088661.
Experimental evidence suggested that CGRP stimulated both constitutive NOS activity and generation of NO via nitrosothiol degradation within the first hour. Paper-12084472.
Incubation of B-CLL cells with TLR-7 agonists effectively resulted in an increased resistance to apoptosis that was reverted with the NOS inhibitor L-NMMA. Paper-12883959.
Recent studies showed that heat shock protein 90 ( HSP90) enhances nitric oxide (NO) synthesis from endothelial and neuronal NO synthase ( eNOS and nNOS, respectively). Paper-9090071.
ROS expression and catalase, glucose-6-phosphate-dehydrogenase ( G6PHD), and NOS/NADPH-diaphorase activity were investigated by using histochemical reactions. Paper-12109361.
The VIP/ nNOS co-localization in myenteric neurons, reported for various regions of the GI tract in different species, suggests that VIP and NO are co-transmitters. Paper-10536889.
Within minutes of adding EGF to transfected cells, RSK1 associated with nNOS and subsequently dissociated following more prolonged agonist stimulation. Paper-12378501.
Effect of Buthus martensi Karsch on aromatase activity and cytokine-inducted NOS and NO production in osteoblasts and leukaemic cell line FLG 29.1. Paper-12156850.
Notably, SUMOylation of CtBP1 was inhibited by the PDZ domain of nNOS, correlating with the known inhibitory effect of nNOS on the nuclear accumulation of CtBP1. Paper-9728240.
RESULTS: Urine levels of NOx and the expression of glomerular eNOS and tubulointerstitial nNOS were significantly decreased in CRF rats compared with normal rats. Paper-12665123.
Using the selective ERbeta agonist, DPN (10nM), we show that activation of ERbeta rapidly increases phosphorylation levels of nNOS at Ser(1412) and NO production. Paper-12994725.
The prooxidant [NAD(P)H oxidase] and antioxidant [ NOS, superoxide dismutase, catalase and glutathione peroxidase] enzyme activities were determined by specific assays. Paper-12214863.
Furthermore, an acute bout of exercise did not alter AMPK alpha1, AMPK alpha2, ACC-beta, or nNOS mu protein expression during the 24-h period after exercise. Paper-13082265.
CONCLUSION: NOS activity decreases AQP2 expression/traffick in the inner collecting duct principal cells in response to hemorrhage and this effect is lower with aging. Paper-12880834.
Inducible-NOS but not neuronal-NOS participate in the acute effect of TNF-alpha on hypothalamic insulin-dependent inhibition of food intake. Paper-12176694.
Furthermore, NO produced from newly induced neuronal NOS was reported to induce expression of thioredoxin and several other genes for preconditioning-induced neuroprotection. Paper-9491883.
With heat, arteriolar blood flow increased (187.2 +/- 28.5%, P = 0.00003), which was significantly attenuated with NOS plus sensorineural blockade (88.6 +/- 37.2%, P = 0.04). Paper-13263020.
The VEGF promoter activity was increased by DDAH2 transfection, which was not blocked by an NO synthase ( NOS) inhibitor but required the Sp1 sites. Paper-12046531.
EDHF-dependent dilatations to acetylcholine ( ACh) were measured in the presence of L-NNA (100 microM, NOS inhibitor) and indomethacin (10 microM, COX inhibitor). Paper-10756686.
Data on the effects of NOS inhibition on lesion volume (mm3, %) and cerebral blood flow ( CBF; %, ml * min(-1) * g(-1)) were analyzed using the Cochrane Review Manager software. Paper-10755582.
Citrulline formed as a by-product of the NOS reaction can be recycled to arginine by argininosuccinate synthetase (AS) and argininosuccinate lyase ( AL). Paper-13247789.
NOS activity - measured by conversion of [(3)H]-L-arginine to [(3)H]-L-citrulline - was enhanced under treatment with both drugs due to inhibition of HMG-CoA reductase. Paper-12521178.
The NO synthase ( NOS) inhibitor N(G)-monomethyl-L-arginine (1 mM) reduced basal levels of c-GMP by 50% but had no effect on telomerase activity or replicative capacity. Paper-13405655.
In addition, subcellular localization of both NOS1 and NOS3 has been shown to regulate enzymatic activity and influence the ability of NOS to produce nitric oxide (NO). Paper-12692695.
Nitric oxide synthase ( NOS) type 1 or neuronal NOS ( nNOS) is expressed in the macula densa and NOS type II or endothelial NOS ( eNOS) in the afferent arteriole. Paper-10067446.
We have discovered that inhibition of hsp90 by radicicol or geldanamycin nearly prevents the heme- mediated activation and assembly of heme-deficient apo- nNOS in insect cells. Paper-9163703.
In endothelial cells, eNOS and CAV-1 were present throughout the vasculature, whereas nNOS and CAV-3 were absent except in capillaries, which reacted for nNOS. Paper-2012232.
It appears that both NOS uncoupling and the activation of NADPH oxidase participate in the changes of reactive oxygen concentrations seen in cerebral hypoxic-ischemic injury. Paper-13024745.
The impaired reendothelialization with CRP was mimicked by NOS antagonism in CF1 mice; conversely, in cultured ECs CRP attenuation of migration was prevented by exogenous NO. Paper-13255698.
We concluded that, estrone rapid action on vascular tissue involves a cross talk between NOS and COX system, and the activation of PLC/ DAG/PKC transduction pathways. Paper-12198970.
Fluvastatin increased eNOS [ endothelial NOS (NO synthase)] expression, but NOS inhibitors failed to reverse the effect of fluvastatin on vWF secretion. Paper-13305019.
RESULTS: Along strands of smooth muscle in the CC and CS, rich numbers of VAChT-, nNOS-, VIP-, TH-, and very few HO-1-immunoreactive (-IR) nerve fibers were observed. Paper-8420466.
These data suggest that NO generated by neuronal NOS exacerbates oxidative damage to cones in RP and that combined therapy to reduce NO and oxidative stress should be considered. Paper-13039847.
Incubation of ferric P420 nNOS with BH4 alone or BH4 and L-arginine resulted in time-dependent reactivation of catalysis and associated recovery of P450 character. Paper-1741961.
The K0.5 for enzyme inhibition by melatonin was determined for nNOS (2.0 +/- 0.1 mm), for XO (0.8 +/- 0.1 mm) and for MPO (0.063 +/- 0.003 mm), the latter one with high affinity. Paper-10181182.
The relationship between excitotoxic stress-generated NO and activation of p38, and the significance of the PSD95- nNOS interaction to p38 activation also remain unclear. Paper-10742331.
While GABAergic genes might underlie reduced anxiety, dysregulation of the glucocorticoid receptor can well contribute to a blunted stress response as found in NOS1 knockdown mice. Paper-12539670.
Insulin treatment decreased platelet adhesion to endothelial cells through insulin stimulation of endothelial NO production and NOS inhibition interfered with this process. Paper-12766174.
PTCL/ NOS are characterised by erratic expression of T cell associated antigens, including CD4 and CD52, which have recently been proposed as targets for ad hoc immunotherapies. Paper-13057188.
These responses were blocked by NMDAR antagonists, removal of extracellular calcium, inhibition of nNOS (neuronal nitric oxide synthase) activity and uncoupling of NMDAR from PSD-95. Paper-13078653.
EDHF-dependent dilatations to acetylcholine ( ACh) were measured in the presence of L-NNA (100 microM, NOS inhibitor) and indomethacin ( INDO; 10 microM, COX inhibitor). Paper-12104178.
Overexpression of NOS- interacting protein ( NOSIP) induces translocation of eNOS from the plasma membrane to intracellular compartments, thereby impairing NO production. Paper-10759169.
Statistical analysis indicated that there is no association of this nNOS variant and MS and hence the gene does not appear to play a genetically significant role in disease susceptibility. Paper-10373114.
The relative contribution of constitutive forms of NOS and COX, as well as interactions between IP, PPARbeta and guanylyl cyclase pathways in vessels and platelets, is discussed. Paper-12673661.
High salt resulted in decreased expression of preproET as well as all three NOS isoforms in the Obese, while cytokine induced NOS ( iNOS) and neuronal NOS ( nNOS) increased in Leans. Paper-13034679.
METHOD: Three oral cancer cell lines were used to investigate the effects of NO synthase enzymes ( NOS) on HIF-1alpha expression under both normal oxygen and hypoxic conditions. Paper-10759445.
BACKGROUND: The role of endothelial nitric oxide synthase 3 ( NOS-3) in the hyperdynamic circulation associated with cirrhosis is established but not that of the neuronal ( NOS-1) isoform. Paper-10525949.
Two different consensus sequences were identified: GIQVD present in nNOS, in DNA cytosine methyl transferase and also in GKAP, where it is present twice in the protein sequence. Paper-9049788.
AM404 completely prevented the overproduction of NO and the overexpression of nNOS, inhibited the increase in tumour necrosis factor alpha (TNFalpha) and enhanced the production of interleukin-10. Paper-12159260.
Both methods revealed that SNPs in genes within the 6q22.3-23.2 and 8q11-q12 linkage peaks, and also the ARG2, FLT1, HAO2 and NOS1 genes were associated with the HbF response to HU. Paper-12622903.
Sheep at high altitude relative to sea level had significantly greater total lung NOS activity and eNOS protein, but reduced sGC and HO expression and carbon monoxide production. Paper-12676463.
Following MTB treatment, the cellular NOS activities were significantly enhanced with a concomitant increase in the levels of constitutive NOS ( cNOS) protein mass (110-178%). Paper-8663274.
Also, the increase in NOS activity and/or content in AP induced NO production that directly inhibited PRL secretion from the AP, without the participation of the dopaminergic system. Paper-12418269.
The carbachol-induced corticosterone response was significantly increased by pretreatment with nNOS inhibitor L-NNA and was considerably reduced by indomethacin, a general COX inhibitor. Paper-12265409.
Inhibition of leptin secretion that had been induced by the IFN-gamma-LPS mixture was completely nullified by NOS inhibitors such as Nomega-monomethyl-L-arginine and aminoguanidine. Paper-12173875.
Genomic DNA from all patients was screened for an intronic AAT-repeat polymorphism in the NOS1 gene using polymerase chain reaction and simple sequence length polymorphism (SSLP) analysis. Paper-9198393.
These results indicate that the NMDAR/ nNOS cascade, activated via MORs, provide the free zinc ions required for inactive PKCgamma to bind to HINT1/ RGSZ complex at the C terminus of the receptor. Paper-12975238.
In mammals, endothelial nitric oxide synthase ( eNOS) has the weakest activity, being one-tenth and one-sixth as active as the inducible NOS ( iNOS) and the neuronal NOS ( nNOS), respectively. Paper-13261573.
These results demonstrate that AT(1) receptor blockade prevents the decrease in conduit artery FMD during NOS inhibition in humans, suggesting the development of a compensatory endothelial mechanism. Paper-13131557.
L-NAME (a nonselective NOS inhibitor) or aminoguanidine (a selective iNOS inhibitor) was given p.o. twice daily for 6 days starting from the termination of DSS treatment. Paper-12879609.
Mean SUV(max) was 8.3 g/ml in the 12 sites with NLP, 11.2 g/ml in the 147 sites affected with NS, 14.6