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NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs. Paper-12592193.
The majority of GnRH neurons are contacted by NPY fibers, and GnRH cells express NPY Y5 receptor ( Y5R). Paper-13560274.
To better characterize these receptor subtypes, we cloned and expressed the Y1, Y2, Y4 and Y5 receptor subtypes from the rabbit. Paper-13786390.
In whites, NPY2R, NPY5R, and SFRP2 SNPs offered suggestive evidence of association with one or more traits ( P < 0.05). Paper-13786005.
These results suggest that rabbit and human Y1, Y2 and Y5 receptor subtypes are well conserved, whereas Y4 receptors are less well conserved. Paper-13786390.
When stimulated by PYY, the Y5 receptor responded with a t(1/2) of 4.6 min and a maximal response approximately 60% of what was observed with Y1. Paper-9746295.
Neuropeptide Y ( NPY) has several receptors; one of them, the neuropeptide Y5 receptor (NPY5) seems involved in feeding behavior in mammals. Paper-11266174.
Genotype analysis of the neuropeptide Y ( NPY) Y1 and NPY Y5 receptor genes in gonadotropin-releasing hormone-dependent precocious gonadarche. Paper-10497872.
Our results show that derived alleles in NPY1R and NPY5R are associated with lower carbohydrate intake, mainly because of a lower consumption of mono- and disaccharides. Paper-13997324.
Neuropeptide Y ( NPY) appears to play a critical role in the integration of appetite and energy expenditure through NPY Y1 and Y5 receptor subtypes. Paper-9303906.
To determine whether increased endogenous NPY tone contributes to GnRH neuronal suppression during lactation, hypothalamic slices were treated with Y5R antagonist. Paper-13560274.
In situ hybridization was used to confirm the presence of NPY, Y2, and Y5 mRNA in the hippocampus of WT mice and the absence of Y5R in knockout mice. Paper-9353786.
Comparison of independent and combined chronic anti-obese effects of NPY Y2 receptor agonist, PYY(3-36), and NPY Y5 receptor antagonist in diet-induced obese mice. Paper-13850257.
Under tetrodotoxin treatment, NPY hyperpolarized GnRH neurons from -56.7 +/- 1.94 to -62.1 +/- 1.83 mV; NPY's effects were blocked by Y5R antagonist. Paper-13560274.
Among blacks, SNPs in IL15, NPY2R, and NPY5R showed strong evidence for association ( P < 0.005); all candidates except EDNRA showed suggestive association ( P < 0.05). Paper-13786005.
These results demonstrate that the Y5R contributes to feeding induced by centrally administered NPY and its analogs, but is not a critical physiological feeding receptor in mice. Paper-1456615.
Binding studies showed that NPY, Y5R-selective agonist peptide, and Y5R-selective antagonist ( CGP71683A) displaced (125)I-PYY binding in BT-549 cell membranes in a dose-dependent manner. Paper-15243885.
The human genes, PPYR1 and NPY5R, have been localized to chromosomes 10q and 4q, respectively, by analysis of a panel of rodent-human somatic cell hybrids and yeast artificial chromosomes. Paper-1288699.
The present study examined and compared the effects of a Y2R agonist, PYY(3-36), and a Y5R antagonist, alone and in combination, on food intake and body weight in diet-induced obese (DIO) mice. Paper-13850257.
Among five NPY receptors described, stimulation of the Y2 receptor ( Y2R) or inhibition of the Y5 receptor ( Y5R) has recently been shown to produce weight-lowering effects in obese rodents. Paper-13850257.
One major player in energy homeostasis is the appetite-stimulating hormone neuropeptide Y, in which the stimulatory capacity may be mediated by the neuropeptide Y receptors 1, 2 and 5 ( NPY1R, NPY2R and NPY5R). Paper-13997324.
CONCLUSION: Genetic variation in NPY1R, NPY2R, NPY5R, CPE, IL15, and SFRP2, detected using linkage analysis in hypertensive siblings, was associated with left ventricular phenotypes in blacks and/or whites. Paper-13786005.
To study the NPY-postsynaptic Y5R system, whole-cell current-clamp recordings were performed in hypothalamic slices from control rats to examine NPY/ Y5R antagonist effects on GnRH neuronal resting membrane potential. Paper-13560274.
NPY deficiency attenuates the obesity syndrome of mice deficient for leptin ( ob/ ob), but these effects are not mediated by NPY signaling through the Y5R because Y5R-null ob/ ob mice are equally obese. Paper-1456615.
BACKGROUND: Several lines of evidence in both human and animal studies suggest that variation in neuropeptide Y ( NPY) or its receptor genes ( NPY1R, NPY2R and NPY5R) is associated with alcohol dependence as well as alcohol withdrawal symptoms. Paper-13547501.
We genotyped a set of 71 single nucleotide polymorphisms ( SNPs) that capture the most common variation in NPY, PPY, PYY, NPY1R, NPY2R, and NPY5R in 2,800 individuals of recent European ancestry drawn from the near extremes of BMI distribution. Paper-13212332.
In both analyses of evoked population spike activity and spontaneous excitatory postsynaptic synaptic currents (EPSCs), NPY agonists induced powerful inhibitory effects in all hippocampal slices from WT mice, whereas these peptides had no effect in slices from Y5R KO mice. Paper-9353786.
Here we demonstrate that NPY, and commonly used Y2R-preferring (NPY(13-36)) and Y5 receptor (Y5R)-preferring ([D-Trp(32)]NPY and hPP) peptide agonists, evoke similar levels of inhibition at excitatory CA3 synapses in hippocampal slices from wild-type control mice (WT). Paper-9353786.
These results illustrate that the combination of a Y2R agonist, PYY(3-36), and a Y5R antagonist resulted in additive effects on body weight and adiposity in DIO mice, suggesting that Y2R stimulation signal and Y5R blockade signal act by distinct pathways. Paper-13850257.
Among five NPY receptors described, the NPY Y5 receptor ( Y5R) is a prime candidate to mediate some of the effects of NPY on energy homeostasis, although its role in physiologically relevant rodent obesity models remains poorly defined. Paper-11836606.
These results suggest that: 1) basal GnRH neuronal activity is suppressed during lactation; 2) NPY can hyperpolarize GnRH neurons via postsynaptic Y5R; and 3) increased inhibitory NPY tone during lactation is a component of the mechanisms responsible for suppression of GnRH neuronal activity. Paper-13560274.
RESULTS: Although single logarithm of the odds (LOD) score peaks of 1.2 or more were found on chromosomes 1, 4, 5, 6, 7, 8, 9, 10, 12, 14, 17, and 21, we observed a broad band of peaks in both ethnic groups (white and black) on chromosome 4 and selected candidate genes ( NPY1R, NPY2R, NPY5R, SFRP2, CPE, IL15, and EDNRA) from this region. Paper-13786005.
These synonyms are used for gene NPY5R (neuropeptide Y receptor Y5): Y5 receptor, NPY-Y5 receptor, NPYY5-R, NPYR5, NPY5-R, Neuropeptide Y receptor type 5.
These accession numbers are used for gene NPY5R: U66275 (NCBI_GENBANK__AC), Q92916 (UNIPROT__AC), Q6GTR7 (UNIPROT__AC), BC042416 (NCBI_GENBANK__AC).
NPY5R is a homologue of NPY5R (neuropeptide Y receptor Y5) from Gallus gallus.
NPY5R is a homologue of NPY5R (neuropeptide Y receptor Y5) from Pan troglodytes.
NPY5R is a homologue of NPY5R (neuropeptide Y receptor Y5) from Canis lupus familiaris.
NPY5R is a homologue of NPY5R (neuropeptide Y receptor Y5) from Bos taurus.
NPY5R is a homologue of NPY5R (neuropeptide Y receptor Y5) from Bos taurus.
NPY5R is a homologue of NPY5R (neuropeptide Y receptor Y5-like) from Bos taurus.
NPY5R is a homologue of Npy5r (neuropeptide Y receptor Y5) from Rattus norvegicus.
NPY5R is a homologue of Npy5r (neuropeptide Y receptor Y5) from Mus musculus.
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