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The Role of PSA- NCAM in Adult Neurogenesis. Paper-13079826.
These results indicate that neither L1 nor NrCAM are required for TAG-1-elicited neurite outgrowth. Paper-9519837.
Also, these studies provide genetic evidence of an interaction between NrCAM and ankyrin-B. Paper-9016649.
Interference with axonin-1 and NrCAM interactions unmasks a floor-plate activity inhibitory for commissural axons. Paper-925846.
It is caused by mutations in L1CAM that encodes a multifunctional transmembrane neuronal cell adhesion molecule. Paper-10553882.
In hypoganglionism, low AChE activity and a slight decrease in NCAM- and SY-immunoreactive nerves were observed. Paper-8781913.
Binding experiments with Fc-chimeric proteins revealed that TAG-1 interacts with L1, NrCAM, and F3/ contactin. Paper-9519837.
Targeted ablation of NrCAM or ankyrin-B results in disorganized lens fibers leading to cataract formation. Paper-9016649.
We will here review the role of guidance cues involved in PCN migration in particular netrin-1, Slit and Nr-CAM. Paper-10747149.
Furthermore we investigated the putative role of L1 and NrCAM as the neuronal TAG-1 receptors mediating neurite extension. Paper-9519837.
These included, neuronal cell adhesion molecule ( NCAM), hyloronidan motility receptor, and myelin proteolipid protein. Paper-9595321.
Binding studies using transfected COS7 cells and immunoprecipitations reveal a direct interaction between neurofascin and NrCAM. Paper-801241.
Neurofascin and NrCAM are two axon-associated transmembrane glycoproteins belonging to the L1 subgroup of the Ig superfamily. Paper-801241.
The neuronal cell adhesion molecule ( NCAM) marker CD56 was reactive in 2 cases of CML, but negative in all cases of AML. Paper-1875879.
The neurofascin- NrCAM binding can be modulated by alternative splicing of specific stretches within neurofascin. Paper-801241.
Under the reverse experimental conditions where NrCAM induces neurite extension, F11, and not neurofascin, serves as axonal receptor. Paper-801241.
SE expressed nonspecific neuronal markers ( NCAM (100%) and NSE (100%)) which showed weak intensity and a GFAP (100%), but not nestin. Paper-11160224.
Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM. Paper-9388157.
We identified the neuronal cell adhesion molecule L1, as a target gene of beta-catenin- TCF signaling in colorectal cancer cells. Paper-10790639.
Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta. Paper-912675.
Antibody blocking experiments demonstrate that neurite extension on immobilized neurofascin is mediated by NrCAM on the axonal surface. Paper-801241.
Here, we will review recent evidence on how PSA- NCAM might regulate the biological properties of new neurons in sites of adult neurogenesis. Paper-13079826.
Here, we propose that CTL effector function correlates better with CD56 ( neuronal cell adhesion molecule ( NCAM)) surface expression. Paper-2101923.
Dominant negative LEF-1 decreased Nr-CAM expression and antibodies to Nr-CAM inhibited the motility of B16 melanoma cells. Paper-9535185.
Environmental impacts on the developing CNS: CD15, NCAM-L1, and GFAP expression in rat neonates exposed to hypergravity. Paper-10915463.
These results suggest that binding of glial RPTPbeta to the contactin/ Nr-CAM complex is important for neurite growth and neuronal differentiation. Paper-912675.
CD56 ( neuronal cell adhesion molecule, N-CAM) has been reported in neuroendocrine tumours and as a marker of reactive biliary epithelial cells. Paper-11387572.
Neuronal cell adhesion molecule ( NCAM) decreased in pyriform cortex and amygdala of kindled rats, indicating neuronal degeneration. Paper-6765743.
In the aganglionic segment of HD there was very intense AChE activity; in contrast, NCAM- and SY-immunoreactive nerve fibers were markedly decreased. Paper-8781913.
Aim To investigate the effect of ghrelin administration on the gastric pH in humans, using a novel wireless pH capsule ( Bravo, Medtronic, Shoreview, MN, USA). Paper-12398825.
480/270 kD ankyrin-G are highly concentrated along with the L1CAM family members neurofascin and NrCAM at nodes of Ranvier and axon initial segments. Paper-8283616.
Here, we demonstrate that the loss of E-cadherin function upregulates expression of the neuronal cell adhesion molecule ( NCAM). Paper-12957027.
We reveal that NrCAM is the neuronal receptor mediating the enhanced outgrowth of retinal neurons, whereas the related F11- binding molecule NgCAM is not involved. Paper-1323422.
Cytokeratin 19 and neuronal cell adhesion molecule showed patchy and moderate staining in the biliary epithelium of the ductules in focal nodular hyperplasia. Paper-12910225.
Neurofascin induces neurites by heterophilic interactions with axonal NrCAM while NrCAM requires F11 on the axonal surface to extend neurites. Paper-801241.
The cell line reacted negatively to antibodies against platelet-derived growth factor and its receptor, neuronal cell adhesion molecule, and glial fibrillary acidic protein. Paper-7201770.
Neurite outgrowth induced by betaCFS was inhibited by antibodies against Nr-CAM and contactin, and these cell adhesion molecules formed a complex that bound betaCFS. Paper-912675.
Axonin-1 and NrCAM were previously shown to be involved in the in vivo guidance of commissural growth cones across the floor plate of the embryonic chicken spinal cord. Paper-925846.
Neurofascin is a member of the L1 subgroup of the Ig superfamily that promotes axon outgrowth by interactions with neuronal NgCAM-related cell adhesion molecule ( NrCAM). Paper-1557402.
Expressions of integrin alpha2, alpha3, alpha5, and beta1, neuronal cell adhesion molecule ( NCAM), and matrix metalloproteinases (MMPs) were examined by flow cytometry. Paper-8631656.
They express high levels of AFP, elevated levels of albumin, low levels of expression of adult liver-specific proteins, low levels of CK19, and a loss of NCAM and CLDN-3. Paper-12154808.
In the murine gene encoding the neuronal cell adhesion molecule ( NCAM), the integrity of the 5' splice site of exon 18 (E18) is essential for regulation of alternative splicing. Paper-1258968.
Nr-CAM is a target gene of the beta-catenin/ LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis. Paper-9535185.
CD56, a natural killer cell marker reactive with the neuronal-cell adhesion molecule ( NCAM), identifies a group of lymphomas with distinctive clinicopathologic features. Paper-7901900.
The neuronal cell adhesion molecule ( NCAM) is a key mediator of structural plasticity in the central nervous system, but the mechanisms that control its expression are unknown. Paper-8462039.
While in the hepatic adenoma, cytokeratin 19 showed only rare positivity in occasional cells within ductules, and neuronal cell adhesion molecule marked occasional isolated cells in the lesion. Paper-12910225.
CNs expressed all neuronal markers except NF (0%), SNP (100%), NCAM (100%), NSE (100%), NeuN (100%), nestin (29%) and chrA (43%), but GFAP expression was found only in one case (14%). Paper-11160224.
Cytokeratin 7, neuronal cell adhesion molecule, and cytokeratin 19 are differentially expressed in hepatocytes, biliary epithelium, and possibly hepatic progenitor/ stem cells. Paper-12910225.
We have shown previously that F11 promotes neurite extension of chick tectal neurons by interaction with the tectal receptor NrCAM, a member of the L1 subgroup of the Ig superfamily. Paper-1323422.
In addition to NrCAM, we here demonstrate that neurofascin also binds to the extracellular matrix glycoprotein tenascin-R ( TN-R) and to the Ig superfamily members axonin-1 and F11. Paper-1557402.
Axonin-1, NgCAM, and NrCAM, three members of the immunoglobulin (Ig) superfamily of cell adhesion molecules (CAMs), were shown to be important for the correct growth pattern of commissural axons. Paper-2094697.
DRG neurons from L1-deficient mice were found to extend neurites on TAG-1 substrates and blocking NrCAM function did not diminish the TAG-1-dependent neurite outgrowth. Paper-9519837.
Although commissural axons readily entered the floor plate under control conditions, perturbations of either axonin-1 or NrCAM interactions prevented the growth cones from entering the floor-plate explants. Paper-925846.
Immunohistochemical analysis was performed using antibodies against cytokeratin 7, cytokeratin 19, neuronal cell adhesion molecule, and CD34 on formalin-fixed, paraffin-embedded sections from each case. Paper-12910225.
In contrast, overexpression of BNIP3, MRC1, EPHB3, GLIS3, CDK4, COL4A2, EBP, NRCAM, and CCNA1 genes in tumors with high proliferation indices was associated with a poor outcome. Paper-13100838.
The results indicate that induction of Nr-CAM transcription by beta-catenin or plakoglobin plays a role in melanoma and colon cancer tumorigenesis, probably by promoting cell growth and motility. Paper-9535185.
Nr-CAM and LEF-1 expression was elevated in human colon cancer tissue and cell lines and in human malignant melanoma cell lines but not in melanocytes or normal colon tissue. Paper-9535185.
Overexpression of either beta-catenin or plakoglobin induced Nr-CAM in a variety of cell types and the LEF/TCF binding sites in the Nr-CAM promoter were required for its activation by catenins. Paper-9535185.
No relationship was observed between abnormalities of NCAM- and SY-immunoreactive nerve fibers and AChE activity, ganglion-cell maturity, heterotopy, or the clinical symptoms presented by the patients with IND B. Paper-8781913.
The nodal axolemma contains high concentrations of voltage-dependent sodium channels as well as the cell adhesion molecules neurofascin and Nr-CAM, all of which are probably linked to the axonal cytoskeleton by ankyrin. Paper-2040407.
Screening for mutations in six genes mapping to 7q, CUTL1, SRPK2, SYPL, LAMB1, NRCAM and PTPRZ1 in 48 unrelated individuals with autism led to the identification of several new coding variants in the genes CUTL1, LAMB1 and PTPRZ1. Paper-11205197.
By contrast, it does not induce outgrowth of retinal neurons despite the fact that these cells also express NrCAM, suggesting that in retinal cells the F11- NrCAM interaction alone is not sufficient to induce neurite extension. Paper-1323422.
With a quantitative dot-immunobinding assay, the time course changes of neuronal cell adhesion molecule ( NCAM) concentrations and total tissue content were monitored in the rat hippocampus after a 40 nmol NMDA injection. Paper-7464368.
SEGA coexpressed several neuronal markers and a glial marker; NeuN (100%), NSE (88%), NCAM (63%), nestin (100%), SNP (weakly and focally, 100%), and GFAP (100%), however, other neuronal markers including chrA, SNP and NF were all negative. Paper-11160224.
One of them uses the neuronal cell adhesion molecule ( NCAM), another employs the synaptic cell adhesion molecule (SynCAM), and the third one consists of neuronal contactin interacting with glial receptor-like protein tyrosine phosphatase-beta. Paper-12872332.
Using Fc fusion proteins and immunocytochemical techniques, we show that beta1 interacts with the fibronectin-like domains of contactin. beta1 also interacts with NrCAM, Nf155, sodium channel beta2, and Nf186 but not with sodium channel beta3. Paper-10649903.
The neuronal biomarkers included nestin, chromogranin A (chrA), synaptophysin ( SNP), neuronal cell adhesion molecule ( NCAM), neuron specific enolase ( NSE), neuronal nuclear antigen ( NeuN), neurofilament (NF) and the glial marker was GFAP. Paper-11160224.
Isoforms of the neuronal cell adhesion molecule ( NCAM) carrying the linear homopolymer of alpha 2,8-linked sialic acid (polysialic acid, PSA) have emerged as particularly attractive candidates for promoting plasticity in the nervous system. Paper-12611840.
In our studies, the expression of neuronal cell adhesion molecule ( NCAM) could be shown in the zona glomerulosa of the normal human adrenal and in the human adrenocortical cell line NCI-H295 that also produces synaptophysin, a synaptic vesicle associated protein. Paper-1573932.
There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule ( NCAM), and the p75 neurotrophin receptor (p75NTR) bind rabies virus and/or facilitate rabies virus entry into cells. Paper-10791780.
Distinct cytokeratin 7, cytokeratin 19, and neuronal cell adhesion molecule staining patterns are seen in hepatic adenoma and focal nodular hyperplasia possibly suggest activation of different subsets of hepatic progenitor/ stem cell and can be diagnostically useful. Paper-12910225.
We also found a 2- to 10-fold upregulation of (beta)ig-h3 (a collagen-binding extracellular matrix protein), NrCAM (a "neural" cell adhesion molecule), Annexin II (a tPA receptor), ESM-1 (an EC-specific molecule of unknown function), and Id2 (an inhibitory bHLH transcription factor). Paper-9388157.
Some of the molecules identified as being important for axon guidance at choice points are conserved between invertebrates and vertebrates (e.g. Robo and netrin), whereas other molecules have been identified, so far, only in invertebrates (e.g. Comm) or vertebrates (e.g. axonin-1 and NrCAM). Paper-1445851.
Mature hepatocytes lack expression altogether of EpCAM, NCAM, AFP, CLDN-3, cytokeratin 19, and have acquired the well-known adult-specific profile that includes expression of high levels of albumin, cytochrome P4503A4, connexins, phosphoenolpyruvate carboxykinase, and transferrin. Paper-12154808.
In vitro neurite outgrowth and cell attachment assays on a neurofascin-Fc substrate reveal a shift of cellular receptor usage from NrCAM to axonin-1, F11, and at least one additional protein in the presence of TN-R, presumably due to competition of the neurofascin- NrCAM interaction. Paper-1557402.
Furthermore, analysis of lenses of ankyrin-B mutant mice also reveals a disorganization of lens fibers at postnatal day 1, indistinguishable from that generated by the absence of NrCAM, indicating that NrCAM and ankyrin-B are required to maintain contact between lens fiber cells. Paper-9016649.
The rectal biopsies and full-thickness colonic biopsy specimens of 17 patients were studied applying histochemical ( acetylcholinesterase [ AChE], lactic dehydrogenase [LDH], and succinic dehydrogenase [SDH] reactions) and immunohistochemical ( neuronal-cell adhesion molecule [ NCAM] and SY antibodies) methods. Paper-8781913.
Several recent studies suggest that isoforms of the neuronal cell adhesion molecule ( NCAM) carrying the linear homopolymer of alpha 2,8-linked sialic acid (polysialic acid, PSA) play a role in regulating several steps of adult neurogenesis including migration, survival and process outgrowth of newly generated neurons. Paper-13079826.
This study identifies Nav1.6 as the voltage-gated sodium channel isoform at mature Purkinje neuron initial segments and reports an essential role for ankyrin-G in coordinating the physiological assembly of Nav1.6, betaIV spectrin, and the L1 cell adhesion molecules (L1 CAMs) neurofascin and NrCAM at initial segments of cerebellar Purkinje neurons. Paper-8858385.
Subsequently, a subset of NCAM translocates from fibroblast growth factor receptor ( FGFR) complexes outside lipid rafts into lipid rafts where it stimulates the non-receptor tyrosine kinase p59(Fyn) leading to the phosphorylation and activation of focal adhesion kinase and the assembly of integrin-mediated focal adhesions. Paper-12957027.
These synonyms are used for gene NRCAM (neuronal cell adhesion molecule): Nr-CAM, NgCAM-related cell adhesion molecule, Ng-CAM-related, Neuronal surface protein Bravo, Neuronal cell adhesion molecule, MGC138846, MGC138845, KIAA0343, hBravo, Bravo.
These accession numbers are used for gene NRCAM: O15179 (UNIPROT__AC), AY528240 (NCBI_GENBANK__AC), AK092330 (NCBI_GENBANK__AC), A4D0S3 (UNIPROT__AC).
NRCAM is a homologue of Nrg (Neuroglian) from Drosophila melanogaster.
NRCAM is a homologue of NRCAM (neuronal cell adhesion molecule) from Bos taurus.
NRCAM is a homologue of NRCAM (neuronal cell adhesion molecule) from Gallus gallus.
NRCAM is a homologue of Nrcam (neuron-glia-CAM-related cell adhesion molecule) from Mus musculus.
NRCAM is a homologue of Nrcam (neuronal cell adhesion molecule) from Rattus norvegicus.
NRCAM is a homologue of nrcam (neuronal cell adhesion molecule) from Danio rerio.
NRCAM is a homologue of lad-2 (L1 CAM ADhesion molecule homolog) from Caenorhabditis elegans.
NRCAM is a homologue of AgaP_AGAP000720 (AGAP000720-PA) from Anopheles gambiae str. PEST.
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