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PYY treatment increased VEGF. Paper-9213010.
ATS abolishes the augmented VEGF response to PYY. Paper-9213010.
Plasma CCK, GLP-1, and PYY concentrations were measured. Paper-1832764.
Metformin increases fasting plasma PYY in women with PCOS. Paper-13072489.
VEGF production is inhibited by vitamin E, but increased by PYY. Paper-9213010.
Basal and fat-stimulated plasma peptide YY levels in celiac disease. Paper-9094793.
PYY inhibited the vagal action more effectively than did NPY. Paper-5091873.
Peptide-YY Is Released by the Intestinal Cell Line STC-1. Paper-13686588.
RESULTS: PYY and GLP-1 colocalized in the same cells in human duodenum. Paper-11513020.
The STC-1 cells were able to secrete PYY in a time-dependent manner. Paper-13686588.
Characterization of a Y1-preferring NPY/ PYY receptor in HT-29 cells. Paper-7907934.
PYY inhibits upper gastrointestinal secretory and motor functions. Paper-1908744.
There was no significant effect of ghrelin on plasma motilin or peptide YY. Paper-12216279.
In contrast, apolipoprotein A-I, B, and C-III mRNA did not respond to peptide YY. Paper-2147085.
Effect of CCK-1 receptor blockade on ghrelin and PYY secretion in men. Paper-13167355.
A peptide YY inhibits the human renin activity in a pH dependent manner. Paper-13656415.
Proteolytic processing of neuropeptide Y and peptide YY by dipeptidyl peptidase IV. Paper-7852140.
Intestinal PYY/ NPY receptors may have pharmacological value for the treatment of diarrhea. Paper-12778455.
4) Peptide YY, in contrast to NPY, is not able to stimulate the release of catecholamines. Paper-9104049.
Co-existence of glucagon with GLP-1, and PP with PYY were observed in some cells. Paper-12805038.
The two PYY genes are expressed in a broad range of tissues including brain and gonads. Paper-11493395.
PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans. Paper-12536533.
DSIP, PYY and SOM levels in CSF were decreased in patients with NPH compared to controls. Paper-7192956.
Moreover, unlike controls, there was no postprandial increase in PYY levels in DP IV-deficient rats. Paper-12140776.
Colocalization of the {alpha}-subunit of gustducin with PYY and GLP-1 in L cells of human colon. Paper-12262852.
Similarly, in PCOS subjects metformin treatment increased fasting PYY concentrations (P < 0.05). Paper-13072489.
METHODS: Barrett's cancer cell lines ( BIC and SEG-1) were treated with PYY (3-36) at 500 pmol/mL. Paper-10901170.
The VIP, but not the CGRP and PYY concentrations seem to be influenced by gastric distension. Paper-846457.
Further, they support a role for PYY and the Y1R in regulating growth in human colonic epithelium. Paper-8637514.
Concentrations of enteroglucagon, GIP, and PYY remained high throughout the six-month study period. Paper-572113.
Mucosal biopsies were taken from the ileum and colon and the content of GLP-2 and PYY was measured. Paper-10783470.
Mutations in the human PYY and Y2 receptor genes may contribute to the development of obesity. Paper-12119367.
Inhibition of protein kinase C (PKC) also blocks PYY- induced MAPK phosphorylation. Paper-1442846.
Immunoreactivity with sera raised against m-INS and PYY was also observed in the stomach of P. buchholzi. Paper-1472444.
GLP-2 has a trophic effect on the intestinal epithelium, whereas PYY has pro-absorptive effects. Paper-10783470.
Peptide YY stimulates the expression of apolipoprotein A-IV gene in Caco-2 intestinal cells. Paper-2147085.
Peptide YY ( PYY) is the most abundant endocrine regulatory peptide localized to the distal bowel. Paper-5795551.
Ghrelin ( GHR) has orexigenic effects, whereas peptide YY ( PYY) reduces intake. Paper-13835151.
Our data suggest that PYY is involved in the regulation of VEGF production and prostate cancer growth. Paper-9213010.
The areas under the curve from 0-120 min for PYY and GLP-1 were similar in both obese and lean participants. Paper-11513020.
BIIE0246, an antagonist for NPY Y(2) receptor, attenuated the suppression of ANP release by PYY. Paper-13543033.
Low serum PYY is linked to insulin resistance in first-degree relatives of subjects with type 2 diabetes. Paper-12294700.
PYY-positive L-cell numbers and NPY innervation were also compared. Paper-12976152.
The cell bodies showed immunoreactivity to galanin, oxytocin, peptide tyrosine tyrosine and glucagon. Paper-8643584.
Both RYGB and BPD were associated with a significant increase in PYY, significantly greater for BDP (p = 0.001). Paper-13030343.
The CCK-1 receptor antagonist Dexlox abolished the effect of ID LCF, on both ghrelin and PYY. Paper-13167355.
Blood samples were drawn for plasma cholecystokinin ( CCK) and PYY measurements. Paper-11266852.
The addition of PYY to TNF-treated cells reduced IRF-1 and p53 binding to control levels. Paper-12294290.
In the temporal cortex of the schizophrenic brains, galanin, AVP, NPY and PYY were significantly reduced. Paper-7191856.
Apolipoprotein A-IV mRNA levels were increased in response to peptide YY in a dose- and time-dependent fashion. Paper-2147085.
SNPs were determined in the GHRL, GHSR, LEP, LEPR, PYY, NPY, NPY2R and CART genes. Paper-13505499.
It is unknown whether fat digestion is a prerequisite for their suppression ( ghrelin) or release ( PYY, PP). Paper-11096141.
Neither the fasting plasma levels nor the meal responses of GLP-2 and PYY differed between controls and IBD patients. Paper-10783470.
Fasting plasma PYY and GHR were assayed in duplicate with Linco enzyme-linked immunosorbent assay kits. Paper-13835151.
Additional investigation of STAT proteins and PYY could provide new therapeutic strategies for pancreatitis. Paper-11829088.
TNF alpha induced elevation of PYY levels in portal plasma with no change in other gut peptide levels. Paper-50624.
Radioimmunoassays for motilin, cholecystokinin ( CCK), NT, PYY and GLP-1 were performed. Paper-1072414.
The assay was highly specific, NPY-related peptides such as pancreatic polypeptide and peptide YY not being detected. Paper-6491453.
In mammals, it binds primarily to the Y4 receptor, to which NPY and peptide YY ( PYY) bind with lower affinities. Paper-9485636.
Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits. Paper-10538042.
The incremental increases in PYY and GLP-1 during that first 20 min were significantly correlated (r2 = 0.388; P < 0.0001). Paper-11513020.
H2-receptor blockade induces peptide YY and enteroglucagon-secreting gastric carcinoids in mastomys. Paper-6485901.
The putative satiety hormone PYY is raised in cardiac cachexia associated with primary pulmonary hypertension. Paper-11115635.
Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/ peptide YY Y2 receptor subtype. Paper-417687.
Thirty-three AA and 54 AW prepubertal children underwent an OGTT measuring ghrelin, PYY, glucose, and insulin. Paper-12081097.
Dipeptidyl peptidase-IV converts PYY to a metabolite PYY-(3-36), a highly selective agonist for the Y2 receptor type. Paper-8077015.
Therefore, tissue levels and meal-stimulated secretion of GLP-2 and PYY were studied in IBD patients and compared to controls. Paper-10783470.
Plasma levels of PYY and GLP-1 were increased by exercise, whereas plasma ghrelin levels were unaffected by exercise. Paper-13684444.
Aminopeptidase-P removes the N-terminal tyrosine from PYY, but the intact peptide is not a substrate for aminopeptidase-N. Paper-8077015.
2. From concentration-response curves in the jejunum EC50 values of 3 nM for PYY and 10 nM for NPY were obtained. Paper-6083359.
Other high affinity substrates of DPP-IV including peptide YY may also play a role in the regulation of energy homeostasis. Paper-12786171.
Postprandial glucose, insulin, leptin, ghrelin, glucagon-like peptide 1, and PYY responses were also studied. Paper-13650841.
NPY is expressed exclusively in neurons, whereas PYY and PP are produced primarily in gut endocrine cells. Paper-426509.
The tendency of PYY to decrease in Japanese FAP might contribute to the development of diarrhoea in these patients. Paper-1867950.
Western blotting revealed that the exogenous peptide YY increased the intracellular concentration of apolipoprotein A-IV. Paper-2147085.
The decreased PYY was associated with the increased NPY expression and their predisposal to obese and overeating in rats. Paper-11447859.
Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. Paper-426509.
In contrast, peptide YY (3-36) ( PYY), an NPY Y(2) receptor agonist, suppressed the release of ANP with positive inotropy. Paper-13543033.
Fasting PYY level correlated positively with glucose infusion rate (r=0.713, p=0.002) and fasting adiponectin (r=0.5, p=0.02). Paper-12294700.
After colonoscopy the patients took a mixed meal and plasma was collected for 90 min for plasma measurements of GLP-2 and PYY. Paper-10783470.
Effect of fatty acid chain length on suppression of ghrelin and stimulation of PYY, GLP-2 and PP secretion in healthy men. Paper-12126834.
GLP-1 and PYY response to food ingestion were enhanced; fasting ghrelin and resistin were significantly reduced (P<0.05). Paper-12286203.
CONCLUSION: The lower suppression of ghrelin in AA, but not the lower PYY levels, correlates with insulinemia and insulin resistance. Paper-12081097.
Cholecystokinin ( CCK), peptide YY ( PYY), and ghrelin have been proposed to act as satiety hormones. Paper-13167355.
In response to the meal, plasma ghrelin was further suppressed, and PYY and PP stimulated, during both FAT and FAT-THL infusions. Paper-11096141.
Somatostatin, PPA, PYY and glucagon immunoreactive cells occurred in a lower frequency in the periphery of pancreatic islets. Paper-13453757.
In addition, argyrophilic cancer cells with immunoreactivities of neuron-specific enolase, chromagranin A and peptide YY were demonstrated. Paper-7151562.
GLU was colocalized with PYY and NPY in a few cells in a small peripheral area in the big islet and a few intermediate islets. Paper-12165762.
NPY and PYY competed with (125)I-hPP at Y4 receptors expressed in CHO cells according to a two-site model. Paper-8774115.
We conclude that the postprandial peripheral plasma concentrations of CGRP, VIP and PYY are dependent on the caloric meal composition. Paper-846457.
Maximal PP responses were unaffected by prior addition of PYY, indicating that Col-1 cells may express a PP specific, Y4-like receptor. Paper-997523.
Ghrelin increased with weight loss and reverted to baseline, whereas leptin and PYY fell at 6 months and remained persistently low. Paper-13668811.
Dipeptidyl peptidase-IV hydrolyzes PYY at the Pro2-Ile3 bond, producing PYY-(3-36), which is a Y2 receptor-selective ligand. Paper-8077015.
A small peptide YY dose (10 pmol/kg) inhibited significantly (P < 0.005) the jejunal net water flux produced by 30 microg/kg per h of VIP. Paper-1217565.
Peptide YY ( PYY) reverses the increased intestinal secretion stimulated by vasoactive intestinal peptide ( VIP) in humans. Paper-7495840.
We hypothesized that tumor necrosis factor (TNF)-alpha would induce STAT1 and STAT3, and PYY would attenuate their transcription factor binding. Paper-11829088.
The authors will review some studies on NA, DA, 5-HT, beta-endorphins, CRH, VP, OT, CCK, NPY and PYY involved in eating disorders. Paper-944430.
OBJECTIVE: We investigated whether aging influenced the secretion of CCK, GLP-1, and PYY and their effects on appetite and pyloric motility. Paper-1832764.
Only non-selective ( PYY) or selective Y1 receptor agonists behaved as potent competitors for [125I][Leu31,Pro34]PYY binding in transfected cells. Paper-660129.
Hormones such as peptide YY, pancreatic polypeptide, glucagon-like peptide-1 and oxyntomodulin are thought to act as postprandial satiety signals. Paper-13547721.
Regulatory peptides such as cholecystokinin ( CCK), vasoactive intestinal polypeptide ( VIP), gastrin and GLP-1 modulate PYY release. Paper-12105003.
Two different co-localization patterns could be distinguished: insulin, IAPP and glucagon, and glucagon, secretin, PP and PYY. Paper-2044457.
Subsequently, we evaluated the effects of 6 months metformin treatment on fasting PYY levels and anthropometric measurements in 20 women with PCOS. Paper-13072489.
DAIR reduces production of ghrelin and resistin and enables more nutrients to be absorbed distally enhancing GLP-1 and PYY secretion. Paper-12286203.
Fat digestion is required for suppression of ghrelin and stimulation of peptide YY and pancreatic polypeptide secretion by intraduodenal lipid. Paper-11096141.
The gastrointestinal hormones cholecystokinin ( CCK), glucagon-like peptide 1 ( GLP-1), and peptide YY ( PYY) may mediate these changes. Paper-1832764.
The " brain stem peptides" CCK and PYY had additive inhibitory effects on reticulospinal inputs, as did the "sensory peptides" CGRP and NPY. Paper-8502351.
CONCLUSIONS/INTERPRETATION: These results provide evidence of association for NPY2R and PYY gene variants with obesity and none for PPY variants. Paper-12454657.
In the gizzard, endocrine cells secreting somatostatin, 5-HT and PYY were detected, while those secreting glucagon and insulin were not. Paper-13554489.
Neuropeptide Y and peptide YY inhibit lipolysis in human and dog fat cells through a pertussis toxin-sensitive G protein. Paper-6524346.
Gastric emptying of glucose solution and associated plasma concentrations of GLP-1, GIP, and PYY before and after fundoplication. Paper-12404582.
TNF-alpha substantially upregulated STAT1 and STAT3 (two-fold or greater); PYY downregulated their binding activity to control levels. Paper-11829088.
Results from both the electrophoretic mobility shift assay- and the ELISA-based assays verified STAT1 and STAT3 responses to TNF-alpha and PYY. Paper-11829088.
In contrast, colonic levels of bombesin, VIP, somatostatin and PYY were significantly lower (P less than 0.05) in older mastomys compared with young. Paper-6814256.
Unlabeled porcine and human NPY and structurally related porcine peptide YY ( PYY) competed with labeled NPY for binding to the receptors. Paper-6818225.
C12 markedly suppressed plasma ghrelin and increased both PYY and GLP-2 (all P < 0.05) compared with control and C10, while C10 had no effect. Paper-12126834.
Lack of cross reactivity of peptide YY ( PYY) and neuropeptide Y ( NPY) with antibodies to pancreatic polypeptide ( PP) in radioimmunoassay. Paper-4322819.
We also quantified its effects on the release of peptide YY ( PYY), neurotensin, human pancreatic polypeptide, gastrin-cholecystokinin, and motilin. Paper-6468367.
Furthermore, we have found that PYY can act in concert with IGF-1 to stimulate cellular responsiveness in pancreatic epithelial cells in vitro. Paper-12362849.
METHODS: We correlated peptide YY ( PYY) and glucagon-like peptide 1 ( GLP-1) changes within the first week after gastric bypass with changes in appetite. Paper-12535408.
In IBD patients with acute inflammation, the content of GLP-2 was similar to controls, whereas PYY was decreased to 72.1+/-17.7% (P=0.03, n=13) of control values. Paper-10783470.
2) LCF significantly inhibited ghrelin levels (P < 0.02) and stimulated PYY release (P < 0.008), whereas MCF were ineffective compared with controls. Paper-13167355.
The aim of this study was to investigate whether STC-1 cells are able to secrete PYY and if so, whether dietary compounds can modulate PYY secretion. Paper-13686588.
The stimulatory effect of TRH (10(-8)6 M) on alpha-MSH release was inhibited by fNPY, pPYY, and [Leu(31),Pro(34)]pNPY, but not by pNPY-(13-36) and [D-Trp(32)]pNPY. Paper-9224941.
BACKGROUND: Disturbances of leptin, neuropeptide Y ( NPY), and peptide YY ( PYY) have been found in women who are ill with anorexia or bulimia nervosa. Paper-8277523.
The effects of doses of NPY were compared with those of equimolar doses of peptide YY ( PYY), and of avian and human pancreatic polypeptides ( APP and HPP). Paper-5091873.
Ghrelin stimulates appetite, and glucagon-like peptide-1, oxyntomodulin, peptide YY, cholecystokinin, and pancreatic polypeptide inhibit appetite. Paper-10266291.
Fourteen cases of gastrointestinal endocrine tumors were examined immunohistochemically for peptide YY, pancreatic polypeptide, glucagon, and somatostatin. Paper-5756580.
In addition, we demonstrate the presence of cells co-expressing PYY and the critical pancreatic transcription factor pancreatic duodenal homeobox1 ( PDX-1). Paper-12362849.
Peptide YY Y1 receptor activates mitogen-activated protein kinase and proliferation in gut epithelial cells via the epidermal growth factor receptor. Paper-8637514.
Ghrelin stimulates, and glucagon like peptide-1, oxyntomodulin, peptide YY ( PYY), cholecystokinin and pancreatic polypeptide inhibit, appetite. Paper-10655682.
Both stimulate glucagon-like peptide-1, but only lipid stimulates peptide YY ( PYY), while only glucose raises blood glucose and stimulates insulin. Paper-13685827.
Blood samples were obtained from 30 cases and 30 controls at the first trial and from 30 cases at the second trial and assayed for peptide YY, TNF-alpha, and IL-1beta. Paper-13050467.
Glucagon, glicentin, proglucagon, PYY, PP and proPP-icosapeptide immunoreactivities of rectal carcinoid tumors and related non-tumor cells. Paper-5767962.
The PP binding was much more sensitive to N5-substituted amiloride inhibitors of Na+ transport than the binding of LP- PYY, or that of hPYY(3-36). Paper-2002326.
5. Recently, yet another NPY receptor, Y3, that is distinct from Y1 and Y2 in that it recognizes PYY poorly, has been demonstrated in the brainstem and in the periphery. Paper-104121.
In addition, we have shown that PYY attenuates transcription factors, such as nuclear transcription factor (NF)-kappaB and Smad3/4, which mediate inflammation. Paper-11829088.
The results support the hypothesis that the effect of PYY on gallbladder emptying is mediated by vagal-dependent rather than cholecystokinin-dependent pathways. Paper-8883849.
We are the first to show that the STC-1 cells are also able to secrete PYY next to cholecystokinin ( CCK) and glucagon-like peptide 1 ( GLP-1). Paper-13686588.
There were PP, PYY, and NPY ( NPY-like) immunoreactivities in a population of glucagon-IR cells in the pancreatic duodenal region ( glucagon/ NPY cells). Paper-2102955.
The levels of VIP, substance P and NPY were higher in the ascending colon than in the descending colon, whereas the opposite pattern was seen for PYY. Paper-9788597.
The use of NPY-related receptor-specific peptides and Y1 receptor antagonist revealed that anti-inflammatory effect of PYY is mediated via NPY Y1 receptors. Paper-12182665.
Ileal interposition is associated with dramatically elevated ileal hormones, GLP-1, PYY, and glucagon (p < 0.01) with no change in the duodenal hormone GIP. Paper-13566642.
The present results suggest that peptide YY modulates apolipoprotein A-IV gene expression, likely via the Y1-receptor subtype in intestinal epithelial cells. Paper-2147085.
In both groups higher levels of cholecystokinin, pancreatic polypeptide, peptide YY, vasoactive intestinal polypeptide, and neuropeptide Y were seen after lipids. Paper-8682371.
This review considers the anorectic peptides PYY, PP, GLP-1, and oxyntomodulin, which decrease appetite and promote satiety in both animal models and humans. Paper-10226292.
Neither GHR nor PYY was significantly related to energy intake or absorption ( GHR: R = 0.22 and R = -0.233, PYY: R = 0.10 and R = -0.13). Paper-13835151.
PYY, ghrelin, GIP, insulin, and glucose concentrations and four markers of satiety were measured for 240 min after a mixed meal. Paper-10991982.
BACKGROUND AND AIM: Glucagon-like peptide-2 ( GLP-2) and peptide YY ( PYY) are produced in endocrine L-cells of the intestine and secreted in response to food intake. Paper-10783470.
Both islet types contained cells with PP/ PYY coexisting with glucagon peptide, while cells showing solely glucagon immunoreactivity were found in type I islets only. Paper-7191139.
Satiety signals derived from the intestine and pancreas include peptide YY, pancreatic polypeptide, glucagon-like peptide 1, oxyntomodulin, and cholecystokinin. Paper-10299707.
Y(1) tone was unchanged in NPY(-/-) but was approximately 90% inhibited in PYY(-/-) and abolished in PYYNPY(-/-) colon mucosa. Paper-12976152.
Peptide YY ( PYY) is a thirty-six amino acid peptide related to neuropeptide Y ( NPY) and is co-secreted with glucagon-like peptide 1. Paper-11123782.
The results of the present study suggest that the PYY-containing enteroendocrine cells and 5-HT-containing mucosal mast cells sense SCFAs via the GPR43 receptor. Paper-11819084.
The PP binding had a high sensitivity to alkali cations and inhibitors of phospholipase C, very similar to that of LP- PYY binding 'masked' by excess cold hPP. Paper-2002326.
There is evidence that the hormone PYY and the neurotransmitter NPY are involved in the regulation of fluid and electrolyte secretion, motility, and blood flow in the intestine. Paper-12778455.
Neuropeptide Y ( NPY) and peptide YY ( PYY) are structurally related peptides that primarily function as neurotransmitter and gastrointestinal hormone, respectively. Paper-7355340.
In addition, literature on the gastrointestinal hormones glucagon-like-peptide 1, apolipoprotein A-IV and peptide YY, and how they may act to regulate satiety, is described. Paper-10136410.
The tumor cells revealed argyrophilia, and were positive for peptide tyrosine tyrosine ( PYY) in the cytoplasm and for CEA in part of the luminal surface. Paper-6859071.
While obese subjects have appropriate reductions in orexigenic ghrelin, other gut-hormone disturbances may contribute to obesity such as reduced anorexigenic PYY and PP. Paper-12157731.
The most well studied in this regard are cholecystokinin ( CCK), pancreatic polypeptide, peptide YY, glucagon-like peptide-1 ( GLP-1), oxyntomodulin and ghrelin. Paper-12136054.
CONCLUSIONS: In morbidly obese adults reducing their weight by bariatric surgery, fasting PYY levels increased and GLP-1 concentrations decreased independently of each other. Paper-12651906.
STUDY DESIGN: Rat pancreatic acinar cells were treated with recombinant TNF-alpha (200 ng/mL); PYY (3-36; 500 pM) was added 30 minutes post- TNF-alpha treatment. Paper-11829088.
Endopeptidase-24.11 ( neutral endopeptidase; enkephalinase) metabolizes PYY efficiently, with a major site of hydrolysis at the Asn29-Leu30 bond, an inactivating cleavage. Paper-8077015.
The aim of the present study was to investigate the mechanisms of the peptide YY effect on vasoactive intestinal peptide (VIP)-stimulated jejunal net water flux in the rat. Paper-1217565.
The binding was blocked only by unlabeled NPY but not by NPY-related peptides i.e. peptide YY, pancreatic polypeptide (avian and human), nor by neurotensin. Paper-5164327.
We suggest that dipeptidyl peptidase IV might be involved in the degradation of neuropeptide Y and peptide YY to N-terminal truncated neuropeptide Y(3-36) and peptide YY(3-36). Paper-7852140.
By Northern blot and reverse transcription polymerase chain reaction analyses, PYY mRNA was expressed in a complete form as detected in normal human colon mucosa. Paper-1738141.
Neuropeptide Y ( NPY), peptide YY ( PYY), and pancreatic polypeptide ( PP) are structurally related peptides found in all higher vertebrates. Paper-426509.
After VIP, the PYY EC50 values (in nM) were 18.6 in Y1-4, 8.0 in Y1-7 and 52.5 in Y1-16 hPP (1 microM) produced only small and transient responses in each transfected cell type. Paper-844401.
Plasma concentrations of gastrin, neurotensin, peptide YY ( PYY), pancreatic polypeptide ( PP), motilin and glucose were monitored before and after meals. Paper-1021727.
Substance P, neurokinin A ( NKA), calcitonin gene-related peptide ( CGRP), vasoactive intestinal peptide ( VIP), and peptide YY ( PYY) were tested. Paper-7849678.
This pathway further requires protein kinase C with EGFR TK inhibition blocking PYY-induced protein kinase Cepsilon (PKCepsilon) translocation to the cell membrane. Paper-8637514.
In obese unoperated patients, the density of PYY and secretin cells was decreased compared with the JIB-patients and the density of the GIP cells compared with both other groups. Paper-9954794.
Phospho- PYY potently inhibits forskolin-stimulated cAMP accumulation in SK-N-MC cells with an IC(50) value of 0.5 nM compared to 0.15 nM for non-phosphorylated PYY. Paper-8707257.
Somatostatin, peptide YY, pancreatic polypeptide, glucagon, ghrelin, and leptin were described as potentially involved from studies mostly performed on animals. Paper-12853378.
Whereas rat and human PP1 bind PP with the same affinity, the rat receptor has much lower affinity than its human ortholog for peptide YY and neuropeptide Y. Paper-560349.
Cell bodies and nerve fibres immunoreactive to PP, PYY, VIP, SP and FMRFamide are present throughout the CNS; the distributions of PHI and SRIF were more restricted. Paper-6819235.
The pancreatic polypeptide-fold family of peptides consists of three 36-amino acid peptides, namely neuropeptide Y ( NPY), peptide YY, and pancreatic polypeptide ( PP). Paper-10065267.
Fasting ghrelin and resistin, and postprandial GLP-1 and PYY were measured.RESULTS: Mean BMI reduction was 4.8, 9.5, 15.4 and 20.1 kg/m(2) respectively at 1, 3, 6 and 12 months. Paper-12286203.
To investigate the influence of maldigestion on PYY, we determined plasma PYY levels in patients with celiac disease under basal conditions and in response to intraduodenal fat. Paper-9094793.
Saturable 125I-porcine PYY binding sites in all regions of the dogfish brain closely resembled the mammalian Y1 NPY receptor subtype in specificity for these substances. Paper-612190.
Neuropeptide Y ( NPY) receptors type 1 (Y1), type 2 Y2) and type 5 (Y5) were tested for their kinetic properties to bind radiolabeled NPY or PYY. Paper-11533772.
CCK and PYY are stimulated during meal intake by the presence of nutrients in the small intestine, especially fat, whereas ghrelin is inhibited by eating. Paper-13167355.
RS-fed rats had decreased body fat, increased POMC expression in the hypothalamic ARC, and elevated plasma PYY and GLP-1 in both the capsaicin and vehicle-treated rats. Paper-13555301.
Venom dipeptidyl peptidase IV-like enzymes probably also contribute to hypotension by destroying vasoconstrictive peptides such as Peptide YY, neuropeptide Y and substance P. Paper-9345136.
The inverse relationship between circulating PYY and CCK in the late postprandial phase is compatible with a negative feedback regulation of CCK release by endogenous PYY. Paper-1908744.
Immunoreactivity was obtained to five peptides, namely pancreatic polypeptide ( PP), peptide YY ( PYY), neuropeptide Y ( NPY), substance P ( SP) and FMRFamide. Paper-33460.
The release of PYY was completely blocked by infusion of somatostatin, and its release from the bowel in normal subjects may therefore be modulated by local somatostatin in the gut. Paper-5086992.
PYY and [Leu31,Pro34]NPY had no effect on release of intracellular calcium alone or on the increase in intracellular calcium concentration caused by carbachol or neurotensin. Paper-7907934.
We hypothesized that TNF-alpha would induce IRF-1 and p53 protein binding in pancreatic acinar cells and that PYY would attenuate the effect. Paper-12294290.
RESULTS: Tissue levels of GLP-2 in control patients were highest in the terminal ileum (407+/-82 pmol/g tissue, n=10), whereas PYY was highest in the rectum (919+/-249 pmol/g tissue, n=10). Paper-10783470.
CONCLUSIONS: Weight reduction with sibutramine is associated with altered gastric functions and increased peptide YY and is significantly associated with SLC6A4 genotype. Paper-13335393.
PP, PYY, and NPY immunoreactivities coexisted in intestinal endocrine cells ( NPY-like peptide containing cells), in some of which there was also glucagon immunoreactivity. Paper-1608125.
The neuropeptide Y ( NPY) family peptides NPY, peptide YY ( PYY), and pancreatic polypeptide ( PP) bind to four G protein-coupled receptors (GPCRs): Y1, Y2, Y4, and Y5. Paper-9746295.
Concentrations of gastrin and cholecystokinin, bombesin, peptide histidine methionine, peptide YY, and neurotensin in plasma were similar in pregnant and nonpregnant women. Paper-6679309.
The high-fat evening meals elevated plasma cholecystokinin concentrations, reduced fasting concentrations of pancreatic polypeptide, and had no significant effect on peptide YY concentrations. Paper-9386361.
CONCLUSION: Endogenous PYY mediates Y(1) absorptive tone that is epithelial in origin, whereas Y(2) tone is a combination of PYY and NPY mediation. Paper-12976152.
Both cleave the peptide hormones glucagon-like peptide-1, glucagon-like peptide-2, neuropeptide Y and peptide YY with marked kinetic differences compared with dipeptidyl peptidase IV. Paper-12000010.
Sham feeding significantly increased plasma concentrations of gastrin and neurotensin ( NT), but did not affect those of cholecystokinin ( CCK), insulin, and peptide YY ( PYY). Paper-7510389.
Additionally in this cell model PYY causes an increase in GTP binding to Ras protein, and cotransfection of dominant negative constructs for Ras and Raf blocks PYY effects on MAPK. Paper-1442846.
However, the postprandial incremental area under curve ( AUC) of PYY was significantly lower in REL after the high carbohydrate (HCHO) meal (+27.3 vs +60.6% increase from baseline, P=0.038). Paper-12837758.
The primary aim of the study was to measure plasma concentrations of three key gut peptides influencing hunger ( ghrelin) and satiety ( PYY, GLP-1) to ascertain potential abnormalities in BED. Paper-12839032.
In ganglionic as well as in aganglionic intestine large populations of cells storing chromogranin A, serotonin, glucagon and PYY and a smaller population of somatostatin cells were seen. Paper-6821863.
Peptide YY Reverses TNF-alpha Induced Transcription Factor Binding of Interferon Regulatory Factor-1 and p53 in Pancreatic Acinar Cells. Paper-12294290.
RESULTS: A total of 28 studies were identified, including sufficient studies to perform a meta-analysis for ghrelin, peptide YY, cholecystokinin, insulin, and pancreatic polypeptide. Paper-13624449.
Conclusion: The rigorous adaptive hyperphagia seen in these patients with short bowel syndrome was not related to fasting GHR or PYY, suggesting the need to explore other mechanisms. Paper-13835151.
MAIN OUTCOME MEASURES: Measures consisted of gastric empty-ing parameters and postprandial plasma levels of ghrelin, cholecystokinin, glucagon-like peptide-1, peptide YY, and motilin. Paper-12216279.
AIMS/HYPOTHESIS: Genetic variants of genes for peptide YY ( PYY), neuropeptide Y2 receptor ( NPY2R) and pancreatic polypeptide ( PPY) were investigated for association with severe obesity. Paper-12454657.
The use of polyclonal specific antisera for somatostatin, glucagon, avian pancreatic polypeptide (APP), YY polypeptide ( PYY) and insulin, revealed a diversified distribution in the pancreas. Paper-13453757.
Inhibition of ECL cell histamine release and calcium signaling is produced by somatostatin acting at a type 2 receptor, histamine acting at a histamine-3 receptor, and by peptide PYY. Paper-997051.
Gastric emptying, gallbladder volume and the plasma levels of CCK, PYY, GLP-1, and ghrelin were determined and appetite sensations were measured using visual analogue scales. Paper-13027116.
In the intestinal tract only a small fraction of somatostatin, gastrin, cholecystokinin, enteroglucagon, enteroglucagon/ peptide tyrosine tyrosine displayed synaptophysin immunoreactivity. Paper-1778212.
They are also rich in histidine decarboxylase activity and produce large amounts of histamine, although other hormones, such as peptide YY and enteroglucagon, have also been demonstrated in these tumors. Paper-7222608.
Ghrelin, peptide YY ( PYY), and pancreatic polypeptide ( PP) appear to play an important role in appetite regulation, and their release is modulated by food ingestion, including fat. Paper-11096141.
Blood samples were obtained at 30 min intervals during both sessions for measurement of glucose, insulin, glucagon, ghrelin, peptide YY ( PYY), and glucagon-like peptide-1 ( GLP-1). Paper-13684444.
Via Y2 receptors, the satiety signal mediated by PYY inhibits NPY neurons and activates pro-opiomelanocortin neurons within the hypothalamic arcuate nucleus. Paper-12669731.
These data demonstrate that lack of PYY enhances insulin secretion from the Islets of Langerhans and that low fasting PYY levels are associated with insulin resistance in humans. Paper-12294700.
The IC(50) values with the Y1, Y2, and Y5 receptor subtypes were for NPY 2.4, 3.1, and 3.3 nM, for PYY 2.3, 0.94, and 3.2 nM, and for phospho- PYY 4.6, 2.2, and 5.5 nM, respectively. Paper-8707257.
Plasma concentrations of gastrin, cholecystokinin, motilin, and peptide YY were measured in the fasting state, immediately after food ingestion, and at 15-min intervals in the postprandial period. Paper-653298.
Plasma CCK, PP, PYY and neurotensin levels were in the same range in the early postprandial phase but were significantly reduced during SST infusion compared with placebo (late postprandial phase). Paper-8733257.
CCK secretion was significantly reduced after VLCT compared to LCT (36 +/- 12 pM x 120 min vs 78 +/- 15 pM x 120 min, P < 0.05), whereas PYY and neurotensin release were not significantly different. Paper-8532143.
Restricted distribution and lack of immunoreactivity for 5-HT, CGRP, or CT suggest that the PYY-positive endocrine cells form a regional subset performing special roles in pulmonary homeostasis. Paper-8151780.
RESULTS: We found these IgG and IgA autoantibodies directed against leptin, ghrelin, peptide YY, neuropeptide Y, and other appetite-regulating peptides are present in human sera at levels of 100-900 ng/mL. Paper-12757909.
The authors evaluated whether GHR or PYY was related to caloric intake or absorption in patients with short bowel syndrome and whether GHR was associated with body mass index. Paper-13835151.
Gastrointestinal hormones, such as ghrelin and peptide YY ( PYY), could be involved as mediators of the alcohol effect because ghrelin stimulates the appetite and PYY appears to induce satiety. Paper-12343339.
Dynorphin A and LHRH inhibited the binding of NPY/ PYY to SK-N-MC cell membranes at concentrations ranging from 10(-7) to 10(-5) M, whereas dynorphin A and CRF were effective in SMS- MSN cells. Paper-138338.
In contrast, other neuropeptides ( neuropeptide Y, somatostatin, substance P, peptide YY, neurokinin A, calcitonin gene-related peptide, chole-cystokinin octapeptide, and beta-endorphin) were ineffective. Paper-773486.
In addition to higher fasting ghrelin concentrations, the PWS children showed significantly higher fasting levels of total peptide YY ( PYY) and gastric inhibitory polypeptide ( GIP) compared to obese controls. Paper-12629762.
Negative feedback from impaired gastric motility, exaggerated long-term adiposity signals ( leptin, insulin) and postprandial anorexigenic signals ( CCK, PYY) seem to prevail over the central feeding drive. Paper-13210603.
CHO K1 cells stably expressing either NPY Y1 or Y2 receptors were shown to specifically bind radiolabelled Peptide YY ( PYY), and MAPK activity in these cells was assessed using a peptide kinase assay. Paper-1683767.
Adjacent sections stained by peroxidase-antiperoxidase (PAP) technique and individual sections stained by immunofluorescence double staining showed the coexistence of glucagon and PP/ PYY-like immunoreactivities. Paper-7191139.
Several other hormones, including cholecystokinin, peptide YY and secretin, released from intestinal endocrine cells in response to food substrates, have significant inhibitory effects on gastric acid secretion. Paper-8175181.
The pretreatment of NPY (18-36), an antagonist for NPY Y(3) receptor, markedly attenuated the stimulation of ANP release by PP but did not affect the suppression of ANP release by PYY. Paper-13543033.
We conclude that the STC-1 cell line provides an appropriate cell line for screening the effects of ingredients on the release of the satiety-related gut hormones CCK, GLP-1, and PYY. Paper-13686588.
The pancreatic polypeptide family includes neuropeptide Y ( NPY), one of the most abundant neuropeptides in the mammalian nervous system, as well as peptide YY ( PYY) and pancreatic polypeptide ( PP). Paper-417687.
Patients with steatorrhea due to chronic destructive pancreatitis also had substantially increased basal PYY levels (47.5 +/- 6.3 pM), and their postprandial response was also greater than that of normal subjects. Paper-5392767.
1229U91 potently displaced [125I]-peptide YY ( PYY) binding to human NPY Y1 receptors ( IC50 = 0.245+/-0.004 nM, n = 4). but displayed little affinity for the human NPY Y2 and Y5 receptors ( IC50 > 1000 nM). Paper-1398453.
The aim of this study was therefore to investigate whether CCK mediated the effect of intraduodenal (ID) fat on ghrelin secretion and PYY release via CCK-1 receptors. Paper-13167355.
These hormones, together with peptide YY ( PYY) and glucagon-like peptide-1 ( GLP-1) have been implicated in the reduction of upper gastrointestinal motility seen after infusion of nutrients into the ileum. Paper-1072414.
Since the effects of OE on food intake appear early, here we studied the effect of OE on the expression of gut peptides that affect short-term ingestive behavior: ghrelin, leptin, CCK, PYY, and GLP-1. Paper-13494711.
Human breast ZR-75 ductal carcinoma ( estrogen receptor negative) and MCF-7 adenocarcinoma ( estrogen receptor positive) cells were cultured and exposed to VES (10 pg/ml), PYY (500 pmol), or both agents together. Paper-8502819.
These results suggest that peptide YY inhibits VIP-stimulated jejunal net water flux in vivo through a neural mechanism implicating the participation of nicotinic synapses, alpha2-adrenoceptors and sigma receptors. Paper-1217565.
Based on [cAMP] radioimmunoassay, the human Y4 receptor exhibits a less selective interaction with rat PP vs. NPY or PYY and a greater dependence on N-terminal PP residues, relative to rat Y4. Paper-1130507.
We addressed whether Orlistat alters the secretion of glucagon-like peptide-1-(7-36)-amide ( GLP-1), cholecystokinin ( CCK), peptide YY ( PYY), and ghrelin as well as postprandial appetite sensations. Paper-13027116.
Our laboratory has previously shown that TNF-alpha induces the binding of many transcription factors, including NF-kappa B, and treatment with the gut hormone, Peptide YY ( PYY), ameliorates the effects. Paper-12294290.
The effects of PYY on enzyme specific activity were compared with those of pancreatic polypeptide, neuropeptide-Y, vasoactive intestinal peptide, pentagastrin, bombesin, and selective Y1- and Y2-receptor agonists. Paper-12270532.
We also investigated whether PYY ablation affects the intrinsic ability of islets to secrete insulin, which may be a contributing factor to the hyperinsulinemia observed in PYY knockout mice. Paper-12294700.
PYY induced expression of tetraspanins and intestinal fatty acid binding protein ( I-FABP) may be part of a mechanism whereby FFA modulate expression of differentiation dependent proteins in the mucosa. Paper-9182658.
OBJECTIVE: To establish the functional significance of endogenous peptide YY ( PYY) and neuropeptide Y ( NPY) as mediators of Y(1) and Y(2) absorptive tone in colonic mucosa. Paper-12976152.
Peripheral venous plasma concentrations of calcitonin gene-related peptide ( CGRP), substance P ( SP), vasoactive intestinal peptide ( VIP), and peptide YY ( PYY) were measured pre- and postprandially. Paper-846457.
Under basal conditions, cotransfection of tagged Y1 receptor and Y5 produced a substantial dimerization signal that was unaffected by the endogenous, nonselective agonists, NPY and peptide YY ( PYY). Paper-12584865.
Generation of LCF through hydrolysis of fat is a critical step for fat-induced inhibition of ghrelin and stimulation of PYY in humans; the signal is mediated via CCK release and CCK-1 receptors. Paper-13167355.
PYY levels incompletely corresponded to reported satiety in the OW group.Discussion:Mixed meal consumption had little effect on ghrelin secretion and a variable effect on PYY secretion in young children in our study. Paper-12756856.
The roles of the gastrointestinal peptides including secretin, CCK, neurotensin, motilin, PYY and pancreatic islet hormones including insulin, pancreatic polypeptide and somatostatin have been established. Paper-10700343.
2. NPY analogues produced a concentration-dependent transient inhibition of the spontaneous contractions of the rabbit ileum with the following order of potency hPP > rPP > PYY > or = [Leu31,-Pro34]-NPY > NPY >> NPY13-36. Paper-1953279.
RESULTS: In lean individuals, atropine led to a decrease in ghrelin concentrations comparable and nonadditive with breakfast ingestion and a significant decrease in both basal and meal- induced PYY concentrations. Paper-12921076.
The same concentration of antagonist abolished responses to PYY and [Leu31,Pro34]NPY but had no effect upon human pancreatic polypeptide ( hPP) in monolayer cultures of the human adenocarcinoma cell line, Colony-6. Paper-834259.
In the gastric mucosa, PYY binds to Y1 receptors in the enterochromaffin-like cells to inhibit gastrin-stimulated histamine release and calcium signaling via a pertussis toxin-sensitive pathway. Paper-9367683.
In conclusion, in healthy humans, 1) the presence of fat in the small intestine suppresses ghrelin secretion, and 2) fat-induced suppression of ghrelin and stimulation of PYY and PP is dependent on fat digestion. Paper-11096141.
Postprandial plasma levels, incremental integrated and total integrated responses for CCK, secretin, insulin, neurotensin, PYY, and enteroglucagon, were significantly greater in patients with primary DGR compared with controls. Paper-7564770.
Not surprisingly, PYY and PP are believed to play an important role in the function of the gastrointestinal tract while NPY is a potent vasconstrictor and may have effects on the gut through the enteric nervous system. Paper-1405294.
These neuronal systems include neuropeptides ( CRH, opioids, neuropeptide-Y ( NPY) and peptide YY ( PYY), vasopressin and oxytocin, CCK, and leptin) and monamines ( serotonin, dopamine, norepinephrine). Paper-9705345.
These neuronal systems include neuropeptides ( CRH, opioids, neuropeptide-Y ( NPY) and peptide YY ( PYY), vasopressin and oxytocin, CCK, and leptin) and monoamines ( serotonin, dopamine, norepinephrine). Paper-9705346.
Levels of corticotropin-releasing hormone ( CRH), gastrin, motilin, neuropeptide Y ( NPY), and peptide YY ( PYY) were determined by radioimmunoassay and high-performance liquid chromatography ( HPLC). Paper-89649.
MAIN OUTCOME MEASURES: Immunostaining of human duodenum, BMI, hemoglobin A1c, plasma glucose, insulin, PYY, glucagon like peptide-1 ( GLP-1), ghrelin, and leptin were the main outcome measures. Paper-11513020.
In this study, the presence of NPY receptors was evaluated in another group of gynecological tumors, namely ovarian tumors, using in vitro receptor autoradiography with (125)I-labeled peptide YY and receptor subtype selective analogs. Paper-10215078.
In the PNS, nerve fibres immunoreactive to PP occur in the bothridia, whilst in the free proglottis nerve fibres immunoreactive to PYY and VIP innervate the gonads; VIP-immunoreactive nerve elements also supply the reproductive ducts. Paper-6819235.
MAIN OUTCOME MEASURES: Fasting and postprandial PYY levels were measured and analyzed for potential correlations with markers for adiposity and insulin resistance.Results:Insulin sensitivity was not different between REL and CON. Paper-12837758.
Protein-induced satiety coincides with a relatively high GLP-1 release, stimulated by the carbohydrate content of the diet, PYY release, while ghrelin does not seem to be especially affected, and little information is available on CCK. Paper-12765581.
Furthermore, six new phenotypes of endocrine-like cells were characterized by their immunoreactivity for PYY, GLP-1, protein gene product 9.5 (PGP), calcitonin gene-related peptide ( CGRP), neurotensin ( NT), and SOM. Paper-202386.
Y receptors (YRs) are G protein-coupled receptors whose Y(1)R, Y(2)R, and Y(5)R subtypes preferentially bind neuropeptide Y ( NPY) and peptide YY, whereas mammalian Y(4)Rs show a higher affinity for pancreatic polypeptide ( PP). Paper-13138454.
Basal PYY was increased in untreated celiac patients (N = 13) compared to patients on a gluten free diet (N = 9) [15.6 (11.8-27.0) pM vs 12.2 (10.1-13.1) pM; P < 0.05] and compared to control subjects (N = 15) [9.5 (8.3-10.4) pM; P < 0.001]. Paper-9094793.
Few physiological substrates have yet been identified for aminopeptidase-P and dipeptidyl peptidase-IV; the pancreatic polypeptide fold family, of which PYY is a member, may well represent endogenous substrates for those cell surface ectoenzymes. Paper-8077015.
In contrast, natural or synthetic neuropeptide Y, which has 25 out of 36 amino acids in common with PYY, retained a high affinity for PYY binding sites [only 4.7 +/- 1.2 (n = 5) times lower than that of PYY]. Paper-5395600.
Neuropeptide-Y ( NPY), peptide YY ( PYY) and pancreatic polypeptide ( PP) are a family of 36-amino-acid peptides, which are widely distributed in the body and act through several subtypes of G-protein-coupled Y receptors. Paper-1573921.
The balance and interaction between anorexigenic ( CCK, PYY, OXM) and orexigenic ( ghrelin and OX) factors originating from GIT appears to play an important role in short-term regulation of food intake and growth hormone ( GH) release. Paper-10548113.
RESULTS: PYY reduced gallbladder emptying in response to modified sham feeding from 23 +/- 5% to 5 +/- 7% (P < 0.01) and integrated plasma pancreatic polypeptide from 2337 +/- 397 pmol/L x 90 min to 903 +/- 232 pmol/L x 90 min (P < 0.01). Paper-8883849.
In addition, HPLC-characterization of motilin, NPY, and PYY showed a different pattern of fragments among patients in groups A and B. In all patients duodenal motilin, PYY, and somatostatin were localized in the endocrine cells. Paper-1404290.
Octreotide therapy improved fluid balance but suppressed gut hormone (insulin, gastrin, glucagon, peptide YY) levels in blood and the uptake of amino acids into pancreatic enzyme and mucosal proteins, increasing oxidative losses. Paper-8224303.
In the tracheal epithelium, endocrine cells immunoreactive to PHI, PYY, and Leu-enkephalin were detected, while immunoreactivity to serotonin, calcitonin, CGRP, PHI, and Leu-enkephalin was found in pulmonary endocrine cells. Paper-8231097.
We therefore temporally related the emptying of fat, protein, and glucose of a mixed meal to release of the gut hormones cholecystokinin, pancreatic polypeptide, and peptide YY and outputs of trypsin, lipase, bilirubin, and bile salts. Paper-6121356.
Of CGA-positive tumors, 70% additionally produced neurohormones, mainly indigenous to normal colorectal epithelium: 55% showed immunoreactivity for glucagon-like substances, 20% for serotonin and 10% for somatostatin, PYY and HCG. Paper-94808.
Here we show, using functional magnetic resonance imaging, that peptide YY3-36 ( PYY), a physiological gut-derived satiety signal, modulates neural activity within both corticolimbic and higher-cortical areas as well as homeostatic brain regions. Paper-12536533.
In meal groups with carbohydrates, acarbose attenuated responses of plasma insulin and glucose-dependent insulinotropic polypeptide ( GIP) while augmenting responses of CCK, glucagon-like peptide-1 ( GLP-1), and peptide YY ( PYY). Paper-9054361.
Neuropeptide Y (NPY)-like and peptide YY (PYY)-like immunoreactivities were measured in cerebrospinal fluid (CSF) from patients with major depressive disorder or schizophrenia and from healthy volunteers without physical or mental illness. Paper-6085948.
There was a negative correlation between fasting ghrelin (but not PYY or GIP) and BMI and insulin (r2= 0.33) and a positive correlation between the decrease in hunger 15 min after the meal and PYY concentrations at 15 min (r2= 0.20). Paper-10991982.
Furthermore, the following neuropeptides are dysregulated in both anorexia nervosa and cancer cachexia: vasoactive intestinal peptide, cholecystokinin, corticotropin-releasing factor, neuropeptide Y, peptide YY and beta-endorphin. Paper-927030.
Plasma levels of CCK (by approximately 53%), PYY (by approximately 40%), and GLP-1 (by approximately 20%) were significantly lowered by Orlistat (P < 0.001), whereas ghrelin levels were unaffected by Orlistat treatment (P = 0.18). Paper-13027116.
Short-term signal hormones including Cholecystokinin ( CCK), Ghrelin, Peptide YY (PYY(3-36)) and Glucagon-like peptide 1 ( GLP-1) control meal size via pathways converging on the hypothalamus. Paper-10981205.
Two-way ANOVA revealed significant (P < 0.05) interaction effects for hunger, acylated ghrelin, and PYY, indicating suppressed hunger and acylated ghrelin during aerobic and resistance exercise and increased PYY during aerobic exercise. Paper-13559141.
Reverse transcriptase-polymerase chain reaction analysis indicated expression also in human cultured vascular smooth muscle cells, supporting the view that the Y1 receptor is associated with NPY/ PYY-evoked vasoconstriction. Paper-7355340.
Forty-one studies were analyzed in order to understand the effects of different operations on the behavior of gut peptides ( ghrelin, cholecystokinin, peptide YY, glucagon-like peptide-1, gastric inhibitory polypeptide, pancreatic polypeptide). Paper-12179547.
No consistent effects of calcium on appetite sensation, or on energy intake at the subsequent meal, or on the postprandial responses of cholecystokinin, glucagon-like peptide 1, ghrelin, peptide YY, insulin, or glucose were observed. Paper-13145672.
RESEARCH DESIGN AND METHODS: We investigated: 1) ghrelin suppression/ PYY elevation in response to an oral glucose tolerance test ( OGTT) in AA vs. AW, and 2) the relationship of ghrelin and PYY dynamics to insulin sensitivity. Paper-12081097.
Distension tended to increase integrated plasma PYY from 77 +/- 30 pM min to 128 +/- 40 pM min in the first hour after the meal (P = 0.08) and it suppressed integrated plasma PP from 1133 +/- 248 pM min to 269 +/- 284 pM min in the second hour (P < 0.05). Paper-8640004.
Hormones including cholescytokinin, peptide YY, gastric inhibitory peptide, neurotensin and pancreatic polypeptide have been proposed to be involved in the mechanism by which MCT may induce satiety; however, the exact mechanisms have not been established. Paper-9395698.
Stomach-derived ghrelin increases food intake even in those with anorexia from chronic illness, while pancreatic polypeptide ( PP), intestinal peptide YY 3-36 ( PYY), oxyntomodulin, and other hormones reduce food intake and appetite. Paper-12157731.
The gut hormone peptide-YY ( PYY) has anorexic effects via the inhibitory neuropeptide Y2 receptor ( Y2R) highly expressed in orexigenic NPY/AGRP neurons within the arcuate nucleus, a major integrator of appetite control in the hypothalamus. Paper-10847768.
CONCLUSIONS: We have shown for the first time that short-term exposure to TNF-alpha induces the binding activity of transcription factors IRF-1 and p53 in rat pancreatic acinar cells, and that addition of PYY reduces it. Paper-12294290.
RESULTS: The postprandial response in plasma ghrelin levels was associated with SNPs in PYY (215G>C, P<0.01) and LEPR (326A>G and 688A>G, P<0.01), and in plasma PYY levels with SNPs in GHRL (-501A>C, P<0.05) and GHSR (477G>A, P<0.05). Paper-13505499.
The direct cerebrovascular responses of peptides with structural similarities with NPY, peptide YY ( PYY), avian ( APP), and bovine (BPP) and human (HPP) pancreatic polypeptides, have been compared with that of NPY on isolated feline cerebral arteries. Paper-5085549.
This may be due to a significant increase in gastric acid output after Roux-en-Y, but gastric emptying and plasma gastrin, cholecystokinin, secretin, gastric inhibitory polypeptide, peptide YY, and neurotensin were similar after both procedures. Paper-7238795.
By immunohistochemistry, GPR43 immunoreactivity was localized to enteroendocrine cells expressing peptide YY ( PYY), whereas 5-hydroxytryptamine (5-HT)-immunoreactive (IR) enteroendocrine cells were not immunoreactive for GPR43. Paper-11819084.
RESULTS: Weight loss after bariatric surgery resulted in improvement of insulin resistance by 54% (p < 0.03) and plasma triglycerides by 26% (p < 0.01) without changes in fasting PYY ( 16.2 +/- 8.7 pmol/l at baseline, 15.1 +/- 6.3 pmol/l at 12 months). Paper-13292761.
The effect of peptide YY, a gastrointestinal hormone, on the expression of the apolipoprotein A-IV gene in the intestinal epithelial cell line Caco-2 was examined by semiquantitative RT-PCR followed by Southern hybridization with an inner oligonucleotide probe. Paper-2147085.
In the Y1-7 clone, BIBP 3226 fully inhibited the reductions in VIP- stimulated SCC induced by 30 nM PYY, with an IC50 of 27.2 nM and 30 nM BIBP 3226 caused a parallel rightward shift on the PYY concentration-response curve, with an approximate pKB of 8. Paper-844401.
Neuropeptide Y ( NPY), peptide YY ( PYY) and pancreatic polypeptide ( PP) belong to the NPY hormone family and activate a class of receptors called the Y-receptors, and also belong to the large superfamily of the G-protein coupled receptors. Paper-8495485.
The order of potency obtained here ( PYY greater than NPY much greater than APP, HPP, CFPP) can be expected to be of use in efforts to distinguish the active site(s) of the NPY molecule, and to characterise the receptors involved in these modulatory effects. Paper-5091873.
METHODS: We examined meal-stimulated responses of insulin, ghrelin, peptide YY ( PYY), glucagon-like-peptide-1 ( GLP-1), and pancreatic polypeptide ( PP) in humans and rodents following different bariatric surgical techniques. Paper-11336236.
With radioimmunoassay, the levels of vasoactive intestinal peptide ( VIP), substance P, neuropeptide Y ( NPY) and peptide YY ( PYY) were analysed in biopsies from the descending colon and ascending colon obtained during colonoscopy. Paper-9788597.
Many peptides are synthesized and released from the gastrointestinal tract and pancreas, including pancreatic polypeptide ( PP) and the products of the gastrointestinal L cells, glucagon-like peptide 1 ( GLP-1), oxyntomodulin, and peptide YY ( PYY). Paper-10226292.
The results suggest that serotonin, substance P-, glucagon-like peptide-1 ( GLP-1)-, peptide tyrosine tyrosine ( PYY)-, neurotensin-, and cholecystokinin (CCK)-producing cells can all arise from a single stem cell located within a given gland. Paper-7273456.
At the end of study, body fat, food intake, plasma peptide YY ( PYY) and glucagon-like peptide 1 ( GLP-1), and hypothalamic pro-opiomelanocortin ( POMC), neuropeptide Y ( NPY), agouti-related peptide (AgRP) gene expressions were measured. Paper-13555301.
This site was Y1 preferring because neuropeptide Y ( NPY) and the Y1-selective agonist [Leu31,Pro34]NPY were equipotent to PYY at displacing 125I-PYY; PYY-(13-36) and pancreatic polypeptide were > 1,000- and 10,000-fold less potent at displacing the radioligand. Paper-7907934.
Semi-quantitative estimation of gene mRNA tissue levels showed that OE markedly decreased ghrelin expression in the stomach; leptin mRNA was unchanged; CCK mRNA decreased in the proximal intestine while PYY and GLP-1 expression in the intestine was not altered. Paper-13494711.
Immunohistochemical studies were carried out using monoclonal and polyclonal antibodies against chromogranin A, synaptophysin (general markers of NE cells), 5-Hydroxytryptamine ( 5-HT), somatostatin, peptide YY ( PYY), and glucagon/glicentin (neuropeptides). Paper-7874467.
Gut hormones are key mediators of this information, including: peptide YY ( PYY), pancreatic polypeptide (PP), glucagon-like peptide 1 ( GLP-1), oxyntomodulin (OXM), ghrelin, amylin and cholecystokinin ( CCK). Paper-13953838.
Intestinal biopsies were homogenized, and levels of the neuropeptides calcitonin gene-related peptide, substance P, peptide YY ( PYY), vasoactive intestinal peptide, somatostatin, galanin, motilin and neurotensin were measured by radioimmunoassay. Paper-10293155.
Introduction of air, saline (isotonic and hypertonic), glucose (isotonic and hypertonic), oleic acid (without bile salts), and casein hydrolysate all failed to release PYY but glucose caused a small but significant increase in enteroglucagon concentrations. Paper-7872052.
We focus on ghrelin and the incretins glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and peptide YY as the most likely candidates for increasing insulin sensitivity after these operations, even before substantial weight loss has occurred. Paper-12333954.
Prominent among intrinsic mediators is peptide YY ( PYY) which is present in approximately 50% of colorectal endocrine cells and neuropeptide Y ( NPY), a neurotransmitter expressed in submucous and myenteric nerves. Paper-12453179.
The three endogenous ligands NPY, peptide YY ( PYY) and pancreatic polypeptide ( PP) have similar affinities as in mammals, i.e. NPY and PYY have subnanomolar affinity for both receptors whereas chicken PP bound with nanomolar affinity to Y5 but not to Y1. Paper-9487016.
However, upon expression in COS1 (confirmed by Northern analysis), COS7 or CHO-K1 cells, the hFB22 receptor did not confer specific 125I-Bolton-Hunter- NPY, 3H-propionyl- NPY or 125I- peptide YY ( PYY) binding sites, in either intact cells or in membrane preparations. Paper-7622879.
This study suggests that peptide YY cells may be a common constituent of rectal endocrine tumors together with pancreatic polypeptide and glucagon cells, and that the peptide YY spectrum of gastrointestinal endocrine tumors may be closely related to the location of the tumors. Paper-5756580.
1229U91 displaced [125I]peptide YY ( PYY) binding to membranes of human neuroblastoma-derived SK-N-MC cells that predominantly express Y1 receptors with a K1 value 0.10 nM and inhibited the NPY-induced increase in intracellular calcium levels(IC50 = 0.27 nM). Paper-767586.
METHODS AND RESULTS: Using double immunohistochemistry and in situ hybridization, we found that GLP-1 was colocalized with either GIP or PYY in endocrine cells of the porcine, rat, and human small intestines, whereas GIP and PYY were rarely colocalized. Paper-9925414.
Neuropeptide Y, peptide YY and pancreatic polypeptide share an evolutionary conserved proline-rich N-terminal sequence, a structure generally known to be inert to the attack of common proteinases, but a potential target for specialized proline-specific aminopeptidases. Paper-7852140.
However, no significant group x time interactions ( ghrelin: p=0.89, CCK: p=0.93, PYY: p=0.68 and insulin: p=0.85) were observed; in addition, there were no differences in an assessment of a three-hour area under the curve after breakfast. Paper-13300104.
Immunohistochemical studies were carried out using monoclonal and polyclonal antibodies against chromogranin A and synaptophysin (general markers of NE cells), 5-hydroxytryptamine ( 5-HT) (a marker of amine), peptide YY ( PYY), and somatostatin (markers of neuropeptides). Paper-7436671.
CONCLUSIONS: Widespread distribution of Y1 receptors in the colonic epithelium and mucosal nerve fibers suggests diverse regulatory roles for peptide YY in modulating epithelial function as well as secretomotor reflexes in response to lumenal peptide YY-release signals. Paper-8315742.
Membrane and autoradiographic receptor binding studies showed specific high-affinity binding sites for the purported Y1-selective radioligands 125I-[Leu31Pro34]peptide YY ( PYY) and 3H-BIBP 3226 in dog spleen, and for the putative Y2-selective 125I-PYY(3-36) in dog and pig spleen. Paper-1683750.
Peptide tyrosine tyrosine/ pancreatic polypeptide ( PYY/ PP)- and C-terminal gastrin/cholecystokinin (G/CCK)-immunoreactive cells were investigated in the intestine of the lizard Podarcis hispanica, using immunocytochemistry with light and electron microscopy. Paper-7321816.
Increased basal and postprandial levels of gastrin (P < 0.05), cholecystokinin ( CCK, P < 0.05), glucose-dependent insulinotropic peptide ( GIP, P < 0.01), peptide YY ( PYY, P < 0.001), and enteroglucagon (P < 0.001), were seen at one month after small bowel resection. Paper-572113.
PYY3-36 is a biopharmaceutical antiobesity agent under development as well as an endogenous satiety hormone, which is generated by dipeptidyl peptidase-IV digestion of polypetide YY ( PYY), and in contrast to the parent hormone, PYY is highly selective for the Y2 versus the Y1 receptor. Paper-12057967.
PYY ablation had no apparent effect on NPY innervation and PYY-positive cells were observed at the same frequency in NPY(-/-) (56.7+/-6.8 cells/section) and WT (55.0+/-4.6 cells/section) colons. Paper-12976152.
We genotyped a set of 71 single nucleotide polymorphisms ( SNPs) that capture the most common variation in NPY, PPY, PYY, NPY1R, NPY2R, and NPY5R in 2,800 individuals of recent European ancestry drawn from the near extremes of BMI distribution. Paper-13212332.
Blockade or loss of this mucosal Y-absorptive tone (i.e. with Y(1) or Y(2) antagonists) leads to hypersecretion and potentially to diarrhea, so Y agonists are predicted to rescue absorption by mimicking endogenous neuroendocrine PYY or neuronal NPY. Paper-12453179.
However, other peptides capable of inhibiting gastric acid secretion in vivo, such as CCK, VIP, and PYY, were unable to induce any inhibition of the parietal cell response to db-cAMP or histamine in the isolated gastric gland preparation irrespective of the species studied. Paper-27992.
The endocrine cells were studied using antibodies against the neuroendocrine marker chromogranin A, the amine serotonin and the hormonal peptides somatostatin, glucagon/glicentin and peptide YY ( PYY), thus covering virtually all endocrine cell types known to occur in this region. Paper-6821863.
The aim of the present study was to investigate if physiologic changes of noradrenaline would evoke any alterations in gastric acid secretion or in the plasma concentration of some gastrointestinal hormones ( gastrin, secretin, PP, PYY, and GIP) known to affect gastric physiology. Paper-5753270.
Since specific binding to Y1, but not to Y2 subtype of neuropeptide Y/ peptide YY receptors requires intact N- as well as C-termini of neuropeptide Y and peptide YY, removal of their amino-terminal dipeptides by dipeptidyl peptidase IV inactivates them for binding to one receptor subtype. Paper-7852140.
The TJM peptide was tested in the in vitro tissue model for potential to enhance permeation of a low-molecular-weight (LMW) drug, namely the acetylcholinesterase inhibitor galantamine, as well as three peptides, salmon calcitonin, parathyroid hormone 1-34 (PTH(1-34)), and peptide YY 3-36 (PYY(3-36)). Paper-11830097.
Infusions of PYY into the brachial artery at 5 pmol/min decreased local vasodilation induced by VIP infused at 2 pmol/min at the same site by 40% (P < 0.01), even though this dose of PYY had no significant effect on local blood flow when given alone.(ABSTRACT TRUNCATED AT 250 WORDS) Paper-7495840.
Using an antiserum directed against the C-terminus of the Y1 receptor we determined the actual extent of Y1 receptor protein expression in the human colon in order to identify areas targeted for peptide YY effects and suggest additional physiological roles for PYY in the human gut. Paper-8315742.
Four immunoreactive cell types were identified within the pancreatic islets (A, B, D, and F cells), using antisera directed against mammalian insulin (m-INS), somatostatins (SST-14, SST-25), and members of the pancreatic polypeptide (aPY, NPY, PYY) and glucagon (GLU, GLP) families. Paper-1472444.
Antropyloroduodenal pressures, plasma CCK, PYY and insulin, blood glucose, and appetite were measured during 90-min intraduodenal infusions of 1) 3 kcal/min lipid (L3), 2) 2 kcal/min lipid and 1 kcal/min maltodextrin (L2/ CHO1), or 3) 1 kcal/min lipid and 2 kcal/min maltodextrin (L1/ CHO2). Paper-13685827.
Infusion of PYY at the lower dose reproduced normal postprandial plasma concentrations and caused significant decreases in glomerular filtration rate (10% reduction), plasma renin activity (30% reduction), and aldosterone levels while increasing sodium excretion by approximately 30% (all P < 0.01). Paper-217743.
In addition, autoradiographic studies show that sites for 125I-labeled Bolton-Hunter NPY or 125I- labeled PYY (2 specific ligands of NPY receptors) are not present in the adenohypophysis, while moderate concentrations of these binding sites are found in the neural lobe of the pituitary. Paper-6584706.
These studies show that butyrate-treated HT-29 cells constitutively express the Y1-preferring NPY/ PYY receptor and Y1 mRNA and provide a new model for studies of PYY- regulated epithelial cell function and tissue-specific expression of the human Y1-receptor gene. Paper-7907934.
RESULTS: Except for the concentrations of CRH, which were increased 2-fold, the tissue concentration of motilin, NPY and PYY were decreased by approximately 50% among patients with esophageal and intestinal dysfunction (group B) compared to patients with impaired esophageal motility alone (group A). Paper-1404290.
PYY, which belongs to a family of peptides including neuropeptide Y ( NPY) and pancreatic polypeptide, is released into the circulation as PYY(1-36) and PYY(3-36); the latter is the major form of PYY in gut mucosal endocrine cells and throughout the circulation. Paper-12669731.
Sixteen hours after CLP or sham operation, portal and systemic blood was drawn, and plasma levels of gastrin, vasoactive intestinal peptide ( VIP), secretin, peptide YY ( PYY), gastrin-releasing peptide ( GRP), and substance P were determined by radioimmunoassay. Paper-50624.
Neither peptide YY ( PYY) or somatostatin 14-28 ( SRIF) reduced short-circuit current (SCC) in Col-1 epithelial layers stimulated with vasoactive intestinal polypeptide ( VIP), suggesting that their respective receptors are either absent in this cell line, or are not functionally coupled. Paper-997523.
No significant differences were noted in PYY, somatostatin and serotonin immunoreactive cells in FAP patients compared to autopsy controls, though PYY cells tended to be decreased and serotonin and somatostatin cells tended to be increased in FAP patients. Paper-1867950.
This review focuses on the roles played by the sensory CVOs in detecting and responding to a number of signals that carry information regarding nutritional status, including cholecystokinin, amylin, ghrelin, peptide YY, pancreatic polypeptide, leptin, adiponectin, and glucose. Paper-13096906.
The peptide hormone recently isolated from anglerfish endocrine pancreas (aPY) (Andrews, P. C., Hawke, D., Shively, J.E., and Dixon, J.E. (1985) Endocrinology 116, 2677-2681), is a member of a family of peptide hormones which includes pancreatic polypeptide, neuropeptide Y, and the gut peptide YY. Paper-5183178.
Various NPY analogs inhibited in a dose-dependent manner the spontaneous secretion of alpha-MSH from perifused frog neurointermediate lobes with the following order of potency porcine peptide YY ( pPYY) > frog NPY (fNPY) > porcine NPY (pNPY)-2-36) > pNPY-(13-36) > [D-Trp(32)]pNPY > [Leu(31),Pro(34)]pNPY. Paper-9224941.
Four peptides were examined; peptide YY ( PYY) and cholecystokinin ( CCK), which are contained in brain stem reticulospinal neurons, and calcitonin-gene-related peptide ( CGRP) and neuropeptide Y ( NPY), which are contained in primary afferents and sensory interneurons, respectively. Paper-8502351.
CONCLUSIONS: Our findings show that PYY and GLP-1 are colocalized and cosecreted from L cells and that total secretion of PYY is higher in females than in males, but fasting PYY levels and PYY secretion in response to oral glucose were not in any way correlated with BMI. Paper-11513020.
Among the neuropeptides, alterations in the levels of neuropeptide Y, peptide YY, beta-endorphin, corticotrophin-releasing hormone, somatostatin, cholecystokinin and vasopressin have been found in the symptomatic phase of bulimia nervosa, with a return to levels seen in controls after remission. Paper-8881803.
In this review we describe our initial studies and the results of more recent investigations into the effects of the gastric hormone ghrelin and the intestinal hormones peptide YY, pancreatic polypeptide, glucagon-like peptide-1, and oxyntomodulin on energy homeostasis. Paper-12398606.
Methionine encephalin, insulin, somatostatin, peptide YY, substance P, basolaterally applied adenosine triphosphate, arginine vasopressin, 5-hydroxytryptamine and epidermal growth factor have all been shown to inhibit fluid and/or HCO(3)(-) secretion from pancreatic ducts. Paper-12364798.
In this study we have characterized the potency of the high affinity peptide dimer antagonist, GR231118, to displace radiolabeled NPY/ PYY from different tissues and cell lines expressing Y1 or Y2 receptors and from CHO cells stably transfected with human cDNA encoding for Y1, Y2 and Y4 receptors. Paper-1459119.
This suggests that the combination of increased PYY levels and elevated levels of DPP-IV observed after bariatric operations may generate increased circulating levels of PYY(3-36), leading to hypothalamic-mediated suppression of appetite and promotion of weight loss through Y2 receptor mediated mechanisms. Paper-12119367.
In fish, the peptide hormones cholecystokinin ( CCK) and peptide Y (PY) may be involved in pancreatic exocrine secretion, as found with mammalian CCK and peptide YY ( PYY); CCK stimulates, whereas PYY inhibits, pancreatic exocrine secretion in mammals. Paper-11325035.
Emphasis is placed on a distributionist "two-tier" model, arguing that traditional short-term (cholescystokinin, ghrelin, peptide YY, glucagon-like peptide 1, etc.) and long-term ( insulin and leptin) feeding signals may be actively suppressed by the nested nuclei and projections of cortical-limbic brain areas. Paper-13225111.
The levels and location of gastrin, gastric inhibitory peptide ( GIP), neurotensin, peptide YY ( PYY), pancreatic polypeptide ( PP), glucagon, bombesin, vasoactive intestinal peptide ( VIP) and somatostatin ( SRIF) were investigated by radioimmunoassay and immunocytochemistry. Paper-6814256.
This cross-sectional study analyzed serum ghrelin, peptide YY ( PYY), glucagon-like peptide-1 ( GLP-1), menstrual status (by E1G and PdG), resting energy expenditure (REE), and subclinical eating behaviours in sedentary ovulatory (SedOv), exercising ovulatory (ExOv), and exercising amenorrheic (ExAmen) women. Paper-13490407.
In the analysis of the hormonal substances coexpressed by CGA-positive cells, immunoreactive serotonin ( SER) was found most frequently, and somatostatin ( SS), gastrin (GAS), glucagon/glicentin (GLU/ GLI), and peptide-tyrosine-tyrosine ( PYY) like immunoreactivities were found in a few tumor cells. Paper-6132734.
A number of circulating factors are produced by peripheral organs, for example, leptin by adipose tissue, insulin and pancreatic polypeptide by the pancreas, gut hormones (e.g., ghrelin, obestatin, glucagon-like peptide-1, oxyntomodulin, peptide YY), and triiodothyronine by the thyroid gland. Paper-13269983.
These results indicate that the interaction of dynorphin A with Y1 and Y2 receptors is not mediated by changes in receptor-G protein interaction, receptor phosphorylation, and allosteric binding to NPY/ PYY receptors but that dynorphin A binds to NPY/ PYY receptors at high concentrations, probably in an antagonistic manner. Paper-138338.
SIGNALLING NETWORK FACTS: Methionine encephalin, insulin, somatostatin, peptide YY, substance P, basolaterally applied adenosine triphosphate, arginine vasopressin, 5-hydroxytryptamine and epidermal growth factor have all been shown to inhibit fluid and/or HCO(3)(-) secretion from pancreatic ducts. Paper-12364798.
Examining for rarer endocrine cell types, we found that cocaine amphetamine regulated transcript (CART) immunoreactive cells were co-localized with SS; and peptide YY ( PYY) immunoreactive cells could be found that were singly immunoreactive or co-localized with either PP or glucagon. Paper-12847753.
We aimed to evaluate the immunocytochemical staining of peptide YY ( PYY) and pancreatic polypeptide ( PP) immunoreactive cells, and detect if alteration of these cells relates to an increase in enterochromaffin cells (EC) demonstrated by chromogranin A ( CgA), in the colonic mucosa of patients with colonic inertia. Paper-11617525.
Ghrelin-, glucagon-, PYY-, gastrin-, somatostatin ( SS)-, pancreatic polypeptide ( PP)-, and insulin-immunoreactive cells are found scattered or in small groups within or lining the developing ductal epithelium as marked by cytokeratin 19. Paper-12378022.
These were somatostatin-, pancreatic polypeptide ( PP)-, peptide YY ( PYY)-, neuropeptide Y ( NPY)-, vasoactive intestinal peptide ( VIP)-, gastric inhibitory peptide ( GIP)-, neurotensin-, cholecystokinin (CCK)/gastrin C-terminus, substance P-, galanin- and serotonin-immunoreactive nerve fibres. Paper-642262.
Concentrations of extractable GIP and PYY were highest in the midjejunum [154 (95-167) and 141 (67-158) pmol/g, median and range, respectively], whereas GLP-1 concentrations were highest in the ileum [92 (80-207) pmol/l], but GLP-1, GIP, and PYY immunoreactive cells were found throughout the porcine small intestine. Paper-9925414.
Both peptides, released from L-cells from the gastrointestinal tract by the local action of digested food, exert various regulatory functions: stimulation of insulin secretion and inhibition of glucagon secretion as typical actions of GLP-1, inhibition of gastric emptying, and inhibition of appetite for both GLP-1 and PYY. Paper-12294880.
Concentrations of plasma total triacylglycerol, chylomicron triacylglycerol, serum total cholesterol, HDL cholesterol, cholecystokinin, glucagon-like peptide 1, ghrelin, peptide YY, glucose, and insulin and appetite sensation were measured before and at regular intervals until 420 min postprandially. Paper-13145672.
EXPERIMENTAL DESIGN: Fifteen adrenal cortical tumors, 20 paragangliomas, 23 pheochromocytomas, 20 neuroblastomas, and 8 normal adrenal glands were investigated by in vitro NPY receptor autoradiography using 125I- labeled peptide YY in competition experiments with receptor subtype selective analogs. Paper-10888331.
METHODS: Levels of corticotrophin-releasing hormone ( CRH), motilin, neuropeptide Y ( NPY) and peptide YY ( PYY) were determined by radioimmunoassay and high-performance liquid chromatography ( HPLC), and the occurrence of motilin, PYY, somatostatin, and NPY were studied with immunohistochemistry. Paper-1404290.
METHODS: We assessed BMD using dual-energy x-ray absorptiometry and measured fasting testosterone, estradiol, IGF-I, leptin, ghrelin, and peptide YY and a bone formation (aminoterminal propeptide of type 1 procollagen) and bone resorption (N-telopeptide of type 1 collagen) marker in 17 AN boys and 17 controls 12-19 yr old. Paper-12900107.
Bonito insulin ( INS)-, synthetic somatostatin-14 (SS-14)-, salmon somatostatin-25 (SS-25)-, mammalian somatostatin-28 (1-12) (SS-28)-, porcine glucagon ( GLU)-, glucagon-like peptide-1 (1-19) ( GLP-1)-, synthetic porcine peptide tyrosine tyrosine ( PYY)-, and neuropeptide Y (NPY)-like immunoreactivities were demonstrated. Paper-12165762.
Other peptides or test substances, including GIP, pancreatic glucagon, somatostatin-14, gastrin, CCK, neurotensin, pancreatic polypeptide, PYY, substance P, histamine and isoproterenol are inactive in this system, while the ubiquitous adenylate cyclase activators NaF, forskolin and prostaglandins were effective. Paper-5074752.
HYPOTHESES: We hypothesized that BMD would be low in adolescent boys with AN compared with controls associated with a decrease in bone turnover markers, and that the gonadal steroids, testosterone and estradiol, and levels of IGF-I and the appetite regulatory hormones leptin, ghrelin, and peptide YY would predict BMD and bone turnover markers. Paper-12900107.
We evaluated neuropeptide Y (NPY) receptor expression in 131 primary human brain tumors, including gliomas, embryonal tumors, meningiomas, and pituitary adenomas, by in vitro receptor autoradiography using the 125I-labeled NPY receptor ligand peptide YY in competition with NPY receptor subtype-selective analogs. Paper-12893339.
Of the four peptide immunoreactivities (IR) demonstrated ( pancreatic polypeptide ( PP), peptide YY ( PYY), substance P ( SP), FMRFamide), PP-IR was the most predominant, occurring not only within the central ganglia and longitudinal nerve cords, but also in subtegumental plexuses and in fibres associated with the egg-forming apparatus. Paper-7878695.
Fasting plasma levels of gastrointestinal growth factors (epidermal growth factor, transforming growth factor-alpha, IGF-II), gastrointestinal hormones ( gastrin, enteroglucagon, peptide YY), and islet hormones (insulin, islet amyloid polypeptide ( IAPP) and pancreatic glucagon) were determined by RIA preoperatively and after five days of treatment. Paper-8669917.
To study the pattern and response of the anorexigenic hormones such as cholecystokinin ( CCK) and peptide YY ( PYY) to a meal in PWS, we measured the plasma CCK, PYY, ghrelin and serum insulin levels in PWS patients (n=4) and in controls (n=4) hourly for a day, and analyzed hormone levels and hormonal responses to meals. Paper-13300104.
In the last 10 years, discoveries of new hormones such as leptin and ghrelin, together with greater understanding of previously described hormones such as cholecystokinin ( CCK), pancreatic polypeptide ( PP), peptide YY ( PYY) and glucagon-like peptide 1 ( GLP-1), have led to a rapid increase in our knowledge of the regulation of energy balance. Paper-11814494.
When expressed in COS1 cells, hY1-5 conferred specific 125I- PYY binding sites with displacement patterns characteristic of the Y1 receptor, i.e. PYY greater than or equal to NPY greater than or equal to [Leu31,Pro34]NPY much greater than NPY2-36 greater than C2NPY greater than pancreatic polypeptide greater than NPY13-36 greater than NPY18-36. Paper-7355340.
BACKGROUND: This study was designed to assess the relationship between gastric emptying of glucose solution and the ensuing plasma concentrations of glucagon-like peptide-1 ( GLP-1), peptide YY ( PYY), and glucose-dependent insulinotropic polypeptide ( GIP) in patients having undergone fundoplication for gastroesophageal reflux ( GERD). Paper-12404582.
To determine whether peptide YY ( PYY), ghrelin, glucose-dependent insulinotropic polypeptide ( GIP), and satiety responses to food intake are impaired in anorexia or obesity, we studied 30 female adolescents with anorexia nervosa [ body mass index (BMI) 16.3 kg/m2], obesity (BMI 34.3 kg/m2), or normal weight (BMI 20.2 kg/m2). Paper-10991982.
The modulation of neuropeptide Y ( NPY) and peptide YY ( PYY) receptors by dynorphin, luteinizing hormone-releasing hormone (LHRH), corticotropin-releasing factor ( CRF), and cholecystokinin octapeptide has been studied in human neuroblastoma cell lines SK-N-MC and SMS- MSN, which express Y1 and Y2 receptors for NPY/ PYY. Paper-138338.
We have evaluated the effects of fatty acid chain length on ghrelin, peptide YY ( PYY), glucagon-like peptide-2 ( GLP-2) and pancreatic polypeptide ( PP) secretion and hypothesized that intraduodenal administration of dodecanoic ("C12"), but not decanoic (" C10"), acid would decrease plasma ghrelin and increase PYY, GLP-2 and PP concentrations. Paper-12126834.
The expression and structure of the receptors for neuropeptide-Y ( NPY) and peptide-YY ( PYY) were studied in 16 human and rodent tumor cell lines derived from the neural crest by ligand binding and cross- linking techniques using [125I]Bolton-Hunter- NPY, [125I]PYY, and various forms of monoiodinated NPY and PYY. Paper-73570.
Glucose, insulin, total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein ( LDL) cholesterol, triglycerides, leptin, active ghrelin, total peptide YY ( PYY), adiponectin, and resistin concentrations were measured. Paper-13878563.
5. The rank order of potency of PYY > or = [Pro34]r/pPYY = [Pro34]hPYY> r/ hNPY = pNPY to stimulate gastric acid secretion upon injection into the DVC and the ineffectiveness of PP, [Leu31,Pro34]NPY and C-terminal NPY/ PYY fragments suggest that a PYY-preferring receptor subtype may be involved in mediating the stimulating effect. Paper-1465347.
The tissue specimens were processed for immunocytochemical demonstration of cells/nerves containing: gastrin, cholecystokinin ( CCK), secretin, gastric inhibitory peptide ( GIP), motilin, somatostatin, serotonin, glicentine, peptide YY ( PYY), neurotensin, vasoactive intestinal peptide ( VIP), substance P, neuropeptide Y ( NPY) and galanin. Paper-9954794.
These synonyms are used for gene PYY (peptide YY): PYY-I, PYY1, Peptide YY, Peptide tyrosine tyrosine.
These accession numbers are used for gene PYY: Q6FGH8 (UNIPROT__AC), Q5U5Q6 (UNIPROT__AC), BAA03000 (NCBI_GENBANK__AC), BAA02998 (NCBI_GENBANK__AC).
PYY is a homologue of pyya (peptide YYa) from Danio rerio.
PYY is a homologue of PYY (peptide YY) from Pan troglodytes.
PYY is a homologue of PYY (peptide YY) from Canis lupus familiaris.
PYY is a homologue of Pyy (peptide YY) from Mus musculus.
PYY is a homologue of Pyy (peptide YY (mapped)) from Rattus norvegicus.
PYY is a homologue of LOC793458 (similar to Peptide Y) from Danio rerio.
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