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PYY treatment increased VEGF. Paper-9213010.
ATS abolishes the augmented VEGF response to PYY. Paper-9213010.
Expression of peptide YY in human brain and pituitary tissues. Paper-12976153.
Plasma CCK, GLP-1, and PYY concentrations were measured. Paper-1832764.
Metformin increases fasting plasma PYY in women with PCOS. Paper-13072489.
Plasma total PYY, ghrelin, insulin, and glucose were assayed. Paper-11145313.
VEGF production is inhibited by vitamin E, but increased by PYY. Paper-9213010.
Basal and fat-stimulated plasma peptide YY levels in celiac disease. Paper-9094793.
PYY inhibited the vagal action more effectively than did NPY. Paper-5091873.
Adiponectin and peptide YY in the fasting blue fox ( Alopex lagopus). Paper-10755340.
Characterization of a Y1-preferring NPY/ PYY receptor in HT-29 cells. Paper-7907934.
PCOS subjects exhibited smaller rises in postprandial levels of total PYY. Paper-13009734.
PYY inhibits upper gastrointestinal secretory and motor functions. Paper-1908744.
Fasting had no acute effects on Acrp30 or PYY concentrations of the blue foxes. Paper-10755340.
There was no significant effect of ghrelin on plasma motilin or peptide YY. Paper-12216279.
In contrast, apolipoprotein A-I, B, and C-III mRNA did not respond to peptide YY. Paper-2147085.
Proteolytic processing of neuropeptide Y and peptide YY by dipeptidyl peptidase IV. Paper-7852140.
Intestinal PYY/ NPY receptors may have pharmacological value for the treatment of diarrhea. Paper-12778455.
4) Peptide YY, in contrast to NPY, is not able to stimulate the release of catecholamines. Paper-9104049.
Co-existence of glucagon with GLP-1, and PP with PYY were observed in some cells. Paper-12805038.
The two PYY genes are expressed in a broad range of tissues including brain and gonads. Paper-11493395.
PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans. Paper-12536533.
After the meal, PYY increased significantly in C (+41%, P < 0.05) but not in AN or OB adolescents. Paper-10991982.
DSIP, PYY and SOM levels in CSF were decreased in patients with NPH compared to controls. Paper-7192956.
Intestinal hormones and regulation of satiety: the case for CCK, GLP-1, PYY, and Apo A-IV. Paper-12978221.
Moreover, unlike controls, there was no postprandial increase in PYY levels in DP IV-deficient rats. Paper-12140776.
Colocalization of the {alpha}-subunit of gustducin with PYY and GLP-1 in L cells of human colon. Paper-12262852.
Similarly, in PCOS subjects metformin treatment increased fasting PYY concentrations (P < 0.05). Paper-13072489.
METHODS: Barrett's cancer cell lines ( BIC and SEG-1) were treated with PYY (3-36) at 500 pmol/mL. Paper-10901170.
The VIP, but not the CGRP and PYY concentrations seem to be influenced by gastric distension. Paper-846457.
Further, they support a role for PYY and the Y1R in regulating growth in human colonic epithelium. Paper-8637514.
Concentrations of enteroglucagon, GIP, and PYY remained high throughout the six-month study period. Paper-572113.
Mutations in the human PYY and Y2 receptor genes may contribute to the development of obesity. Paper-12119367.
Inhibition of protein kinase C (PKC) also blocks PYY- induced MAPK phosphorylation. Paper-1442846.
Immunoreactivity with sera raised against m-INS and PYY was also observed in the stomach of P. buchholzi. Paper-1472444.
Peptide YY stimulates the expression of apolipoprotein A-IV gene in Caco-2 intestinal cells. Paper-2147085.
Peptide YY ( PYY) is the most abundant endocrine regulatory peptide localized to the distal bowel. Paper-5795551.
Our data suggest that PYY is involved in the regulation of VEGF production and prostate cancer growth. Paper-9213010.
Low serum PYY is linked to insulin resistance in first-degree relatives of subjects with type 2 diabetes. Paper-12294700.
However, 1229U91 also displaces (125)I- peptide YY ( PYY) with high affinity from the Y4 subtype. Paper-2172689.
The cell bodies showed immunoreactivity to galanin, oxytocin, peptide tyrosine tyrosine and glucagon. Paper-8643584.
Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men. Paper-10793188.
It is unknown whether fat digestion is a prerequisite for their suppression ( ghrelin) or release ( PYY, PP). Paper-11096141.
Both RYGB and BPD were associated with a significant increase in PYY, significantly greater for BDP (p = 0.001). Paper-13030343.
Pharmacological characterization of (125)I-1229U91 binding to Y1 and Y4 neuropeptide Y/ Peptide YY receptors. Paper-2172689.
The addition of PYY to TNF-treated cells reduced IRF-1 and p53 binding to control levels. Paper-12294290.
In the temporal cortex of the schizophrenic brains, galanin, AVP, NPY and PYY were significantly reduced. Paper-7191856.
Addition of both Y1 and Y5 receptor antagonists was required to significantly decrease PYY-induced internalization. Paper-12584865.
Apolipoprotein A-IV mRNA levels were increased in response to peptide YY in a dose- and time-dependent fashion. Paper-2147085.
CONTEXT: The gut hormone peptide YY(3-36) ( PYY) reduces food intake via hypothalamic Y2 receptors in the brain. Paper-11513043.
The effects of cholecystokinin, glucagon-like peptide I, peptide YY, and apolipoprotein A-IV are described. Paper-12978221.
Additional investigation of STAT proteins and PYY could provide new therapeutic strategies for pancreatitis. Paper-11829088.
Acrp30 and PYY were present in blue fox plasma at similar or lower levels as reported previously for other mammals. Paper-10755340.
TNF alpha induced elevation of PYY levels in portal plasma with no change in other gut peptide levels. Paper-50624.
Radioimmunoassays for motilin, cholecystokinin ( CCK), NT, PYY and GLP-1 were performed. Paper-1072414.
Fasting ghrelin and resistin and fasting and postprandial GLP-1 and PYY were measured pre- and postoperatively. Paper-12703284.
Plasma samples were taken in order to analyse levels of motilin, peptide YY, cholecystokinin, and somatostatin. Paper-11451160.
Effects of chronic treatment of olanzapine and haloperidol on peptide YY binding densities in the rat brain. Paper-12681732.
The assay was highly specific, NPY-related peptides such as pancreatic polypeptide and peptide YY not being detected. Paper-6491453.
In mammals, it binds primarily to the Y4 receptor, to which NPY and peptide YY ( PYY) bind with lower affinities. Paper-9485636.
Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits. Paper-10538042.
H2-receptor blockade induces peptide YY and enteroglucagon-secreting gastric carcinoids in mastomys. Paper-6485901.
The putative satiety hormone PYY is raised in cardiac cachexia associated with primary pulmonary hypertension. Paper-11115635.
Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/ peptide YY Y2 receptor subtype. Paper-417687.
Thirty-three AA and 54 AW prepubertal children underwent an OGTT measuring ghrelin, PYY, glucose, and insulin. Paper-12081097.
RESULTS: Obese children demonstrated significantly lower PYY levels than lean children (median, 67 vs. 124 pg/ml; P < 0.001). Paper-11513043.
Dipeptidyl peptidase-IV converts PYY to a metabolite PYY-(3-36), a highly selective agonist for the Y2 receptor type. Paper-8077015.
Pharmacologically, the receptor exhibited high affinity for NPY, PYY, and carboxyl-terminal fragments of NPY and PYY. Paper-548218.
Aminopeptidase-P removes the N-terminal tyrosine from PYY, but the intact peptide is not a substrate for aminopeptidase-N. Paper-8077015.
Peptide YY and Glucagon-like Peptide-1 in Morbidly Obese Patients Before and After Surgically Induced Weight Loss. Paper-12651906.
Other high affinity substrates of DPP-IV including peptide YY may also play a role in the regulation of energy homeostasis. Paper-12786171.
PYY was infused intravenously at low doses (0.4 and 0.2 pmol.kg-1.min-1) for 100 min each during the continuous VIP infusion. Paper-6823061.
NPY is expressed exclusively in neurons, whereas PYY and PP are produced primarily in gut endocrine cells. Paper-426509.
Rats were killed to measure PYY, ghrelin, cholecystokinin ( CCK), and glucagonlike peptide-1 ( GLP-1). Paper-11057912.
Appetite-related gut peptides, ghrelin, PYY, and GLP-1 in obese women with and without binge eating disorder (BED). Paper-12839032.
The tendency of PYY to decrease in Japanese FAP might contribute to the development of diarrhoea in these patients. Paper-1867950.
Western blotting revealed that the exogenous peptide YY increased the intracellular concentration of apolipoprotein A-IV. Paper-2147085.
The decreased PYY was associated with the increased NPY expression and their predisposal to obese and overeating in rats. Paper-11447859.
Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. Paper-426509.
Somatostatin also lowered plasma PYY levels by 45 +/- 16% (P = 0.04), and produced post-prandial hyperglycemia (P = 0.04). Paper-10514125.
Fasting PYY level correlated positively with glucose infusion rate (r=0.713, p=0.002) and fasting adiponectin (r=0.5, p=0.02). Paper-12294700.
Effect of fatty acid chain length on suppression of ghrelin and stimulation of PYY, GLP-2 and PP secretion in healthy men. Paper-12126834.
In response to the meal, plasma ghrelin was further suppressed, and PYY and PP stimulated, during both FAT and FAT-THL infusions. Paper-11096141.
GLP-1 and PYY response to food ingestion were enhanced; fasting ghrelin and resistin were significantly reduced (P<0.05). Paper-12286203.
Concentrations of plasma PYY were increased, while plasma ghrelin was decreased in RYGB versus SO Obese and PF (P < .05). Paper-11057912.
CONCLUSION: The lower suppression of ghrelin in AA, but not the lower PYY levels, correlates with insulinemia and insulin resistance. Paper-12081097.
Ghrelin, peptide YY and their receptors: gene expression in brain from subjects with and without Prader-Willi syndrome. Paper-11105080.
Fasting ghrelin and resistin were significantly reduced (P < 0.05); GLP-1 and PYY response to food ingestion was enhanced (P < 0.05). Paper-12703284.
It reduces production of ghrelin and resistin and takes more nutrients to be absorbed distally enhancing GLP-1 and PYY secretion. Paper-12703284.
In addition, argyrophilic cancer cells with immunoreactivities of neuron-specific enolase, chromagranin A and peptide YY were demonstrated. Paper-7151562.
GLU was colocalized with PYY and NPY in a few cells in a small peripheral area in the big islet and a few intermediate islets. Paper-12165762.
CONCLUSION: A common and conserved variant of the PYY and NPY receptor Y2R is less prevalent among obese compared to among lean Swedish men. Paper-10847768.
Postprandial response of ghrelin and PYY and indices of low-grade chronic inflammation in lean young women with polycystic ovary syndrome. Paper-13009734.
In conclusion, the blunted PYY response to a meal in OB adolescents suggests that PYY plays a role in the pathophysiology of obesity. Paper-10991982.
NPY and PYY competed with (125)I-hPP at Y4 receptors expressed in CHO cells according to a two-site model. Paper-8774115.
We conclude that the postprandial peripheral plasma concentrations of CGRP, VIP and PYY are dependent on the caloric meal composition. Paper-846457.
Maximal PP responses were unaffected by prior addition of PYY, indicating that Col-1 cells may express a PP specific, Y4-like receptor. Paper-997523.
When stimulated by PYY, the Y5 receptor responded with a t(1/2) of 4.6 min and a maximal response approximately 60% of what was observed with Y1. Paper-9746295.
Y(1) tone was unchanged in NPY(-/-) but was approximately 90% inhibited in PYY(-/-) and abolished in PYYNPY(-/-) colon mucosa. Paper-12976152.
Dipeptidyl peptidase-IV hydrolyzes PYY at the Pro2-Ile3 bond, producing PYY-(3-36), which is a Y2 receptor-selective ligand. Paper-8077015.
PYY, ghrelin, GIP, insulin, and glucose concentrations and four markers of satiety were measured for 240 min after a mixed meal. Paper-10991982.
A small peptide YY dose (10 pmol/kg) inhibited significantly (P < 0.005) the jejunal net water flux produced by 30 microg/kg per h of VIP. Paper-1217565.
Fat digestion is required for suppression of ghrelin and stimulation of peptide YY and pancreatic polypeptide secretion by intraduodenal lipid. Paper-11096141.
Peptide YY ( PYY) reverses the increased intestinal secretion stimulated by vasoactive intestinal peptide ( VIP) in humans. Paper-7495840.
We hypothesized that tumor necrosis factor (TNF)-alpha would induce STAT1 and STAT3, and PYY would attenuate their transcription factor binding. Paper-11829088.
The authors will review some studies on NA, DA, 5-HT, beta-endorphins, CRH, VP, OT, CCK, NPY and PYY involved in eating disorders. Paper-944430.
OBJECTIVE: We investigated whether aging influenced the secretion of CCK, GLP-1, and PYY and their effects on appetite and pyloric motility. Paper-1832764.
Only non-selective ( PYY) or selective Y1 receptor agonists behaved as potent competitors for [125I][Leu31,Pro34]PYY binding in transfected cells. Paper-660129.
Regulatory peptides such as cholecystokinin ( CCK), vasoactive intestinal polypeptide ( VIP), gastrin and GLP-1 modulate PYY release. Paper-12105003.
Two different co-localization patterns could be distinguished: insulin, IAPP and glucagon, and glucagon, secretin, PP and PYY. Paper-2044457.
Moreover, reverse transcription polymerase chain reaction analysis showed expression of mRNA for PYY in human brain and pituitary tissues. Paper-12976153.
Subsequently, we evaluated the effects of 6 months metformin treatment on fasting PYY levels and anthropometric measurements in 20 women with PCOS. Paper-13072489.
DAIR reduces production of ghrelin and resistin and enables more nutrients to be absorbed distally enhancing GLP-1 and PYY secretion. Paper-12286203.
The gastrointestinal hormones cholecystokinin ( CCK), glucagon-like peptide 1 ( GLP-1), and peptide YY ( PYY) may mediate these changes. Paper-1832764.
Gastric emptying of glucose solution and associated plasma concentrations of GLP-1, GIP, and PYY before and after fundoplication. Paper-12404582.
The " brain stem peptides" CCK and PYY had additive inhibitory effects on reticulospinal inputs, as did the "sensory peptides" CGRP and NPY. Paper-8502351.
CONCLUSIONS/INTERPRETATION: These results provide evidence of association for NPY2R and PYY gene variants with obesity and none for PPY variants. Paper-12454657.
Peptide YY ( PYY) is a thirty-six amino acid peptide related to neuropeptide Y ( NPY) and is co- secreted with glucagon-like peptide 1. Paper-11123782.
Peptide YY ( PYY) is released postprandially from gastrointestinal L-cells with glucagon-like peptide 1 ( GLP-1) and oxyntomodulin. Paper-11442598.
A lesser postprandial suppression of plasma ghrelin in Prader-Willi syndrome is associated with low fasting and a blunted postprandial PYY response. Paper-12425345.
Neuropeptide Y and peptide YY inhibit lipolysis in human and dog fat cells through a pertussis toxin-sensitive G protein. Paper-6524346.
TNF-alpha substantially upregulated STAT1 and STAT3 (two-fold or greater); PYY downregulated their binding activity to control levels. Paper-11829088.
Results from both the electrophoretic mobility shift assay- and the ELISA-based assays verified STAT1 and STAT3 responses to TNF-alpha and PYY. Paper-11829088.
However, PYY is also involved in a wide range of digestive functions including regulating insulin secretion and glucose homeostasis. Paper-12453199.
Unlabeled porcine and human NPY and structurally related porcine peptide YY ( PYY) competed with labeled NPY for binding to the receptors. Paper-6818225.
Several hormones, including peptide YY, pancreatic polypeptide, oxyntomodulin, glucagon-like peptide 1 and cholecystokinin function as satiety signals. Paper-12711366.
Pulmonary hydrogen and methane excretion and plasma glucagon-like peptide 1 ( GLP-1) and peptide YY ( PYY) levels were measured during the next 3 h. Paper-13003334.
C12 markedly suppressed plasma ghrelin and increased both PYY and GLP-2 (all P < 0.05) compared with control and C10, while C10 had no effect. Paper-12126834.
METHODS: We correlated peptide YY ( PYY) and glucagon-like peptide 1 ( GLP-1) changes within the first week after gastric bypass with changes in appetite. Paper-12535408.
We also quantified its effects on the release of peptide YY ( PYY), neurotensin, human pancreatic polypeptide, gastrin-cholecystokinin, and motilin. Paper-6468367.
Furthermore, we have found that PYY can act in concert with IGF-1 to stimulate cellular responsiveness in pancreatic epithelial cells in vitro. Paper-12362849.
The stimulatory effect of TRH (10(-8)6 M) on alpha-MSH release was inhibited by fNPY, pPYY, and [Leu(31),Pro(34)]pNPY, but not by pNPY-(13-36) and [D-Trp(32)]pNPY. Paper-9224941.
BACKGROUND: Disturbances of leptin, neuropeptide Y ( NPY), and peptide YY ( PYY) have been found in women who are ill with anorexia or bulimia nervosa. Paper-8277523.
The effects of doses of NPY were compared with those of equimolar doses of peptide YY ( PYY), and of avian and human pancreatic polypeptides ( APP and HPP). Paper-5091873.
Ghrelin stimulates appetite, and glucagon-like peptide-1, oxyntomodulin, peptide YY, cholecystokinin, and pancreatic polypeptide inhibit appetite. Paper-10266291.
Fourteen cases of gastrointestinal endocrine tumors were examined immunohistochemically for peptide YY, pancreatic polypeptide, glucagon, and somatostatin. Paper-5756580.
In addition, we demonstrate the presence of cells co-expressing PYY and the critical pancreatic transcription factor pancreatic duodenal homeobox1 ( PDX-1). Paper-12362849.
Peptide YY Y1 receptor activates mitogen-activated protein kinase and proliferation in gut epithelial cells via the epidermal growth factor receptor. Paper-8637514.
Ghrelin stimulates, and glucagon like peptide-1, oxyntomodulin, peptide YY ( PYY), cholecystokinin and pancreatic polypeptide inhibit, appetite. Paper-10655682.
Subjective appetite and circulating glucose, insulin, ghrelin, cholecystokinin, and peptide YY were assessed at 0, 15, 30, 45, 60, 90, 120, and 180 min. Paper-12638433.
Fasting glucose to insulin ratio (G(F)/I(F)) was used to assess the relationship of insulin sensitivity to fasting and post-OGTT ghrelin and PYY levels. Paper-12081097.
Blood samples were obtained from 30 cases and 30 controls at the first trial and from 30 cases at the second trial and assayed for peptide YY, TNF-alpha, and IL-1beta. Paper-13050467.
Glucagon, glicentin, proglucagon, PYY, PP and proPP-icosapeptide immunoreactivities of rectal carcinoid tumors and related non-tumor cells. Paper-5767962.
The PP binding was much more sensitive to N5-substituted amiloride inhibitors of Na+ transport than the binding of LP- PYY, or that of hPYY(3-36). Paper-2002326.
5. Recently, yet another NPY receptor, Y3, that is distinct from Y1 and Y2 in that it recognizes PYY poorly, has been demonstrated in the brainstem and in the periphery. Paper-104121.
In addition, we have shown that PYY attenuates transcription factors, such as nuclear transcription factor (NF)-kappaB and Smad3/4, which mediate inflammation. Paper-11829088.
The results support the hypothesis that the effect of PYY on gallbladder emptying is mediated by vagal-dependent rather than cholecystokinin-dependent pathways. Paper-8883849.
Human PP inhibited binding with a Ki of 0.023 nM, whereas human PYY (Ki = 0.31 nM) and human NPY Ki = 12 nM) were significantly less potent. Paper-606057.
There were PP, PYY, and NPY ( NPY-like) immunoreactivities in a population of glucagon-IR cells in the pancreatic duodenal region ( glucagon/ NPY cells). Paper-2102955.
The levels of VIP, substance P and NPY were higher in the ascending colon than in the descending colon, whereas the opposite pattern was seen for PYY. Paper-9788597.
The use of NPY-related receptor-specific peptides and Y1 receptor antagonist revealed that anti-inflammatory effect of PYY is mediated via NPY Y1 receptors. Paper-12182665.
Pharmacological studies indicate that peptide YY ( PYY) and neuropeptide Y interact with multiple binding sites, categorized as Y1 and Y2 subtypes. Paper-6815197.
The present results suggest that peptide YY modulates apolipoprotein A-IV gene expression, likely via the Y1-receptor subtype in intestinal epithelial cells. Paper-2147085.
In both groups higher levels of cholecystokinin, pancreatic polypeptide, peptide YY, vasoactive intestinal polypeptide, and neuropeptide Y were seen after lipids. Paper-8682371.
This review considers the anorectic peptides PYY, PP, GLP-1, and oxyntomodulin, which decrease appetite and promote satiety in both animal models and humans. Paper-10226292.
Via Y2 receptors, the satiety signal mediated by PYY inhibits NPY neurons and activates pro-opiomelanocortin neurons within the hypothalamic arcuate nucleus. Paper-12669731.
Both islet types contained cells with PP/ PYY coexisting with glucagon peptide, while cells showing solely glucagon immunoreactivity were found in type I islets only. Paper-7191139.
Satiety signals derived from the intestine and pancreas include peptide YY, pancreatic polypeptide, glucagon-like peptide 1, oxyntomodulin, and cholecystokinin. Paper-10299707.
Postprandial ghrelin, cholecystokinin, peptide YY, and appetite before and after weight loss in overweight women with and without polycystic ovary syndrome. Paper-12638433.
The results of the present study suggest that the PYY-containing enteroendocrine cells and 5-HT-containing mucosal mast cells sense SCFAs via the GPR43 receptor. Paper-11819084.
The PP binding had a high sensitivity to alkali cations and inhibitors of phospholipase C, very similar to that of LP- PYY binding 'masked' by excess cold hPP. Paper-2002326.
There is evidence that the hormone PYY and the neurotransmitter NPY are involved in the regulation of fluid and electrolyte secretion, motility, and blood flow in the intestine. Paper-12778455.
At 1, 3 and 6 months after operation, progressively increasing peptide YY (P < 0.001), enteroglucagon (P = 0.045) and glucagon-like peptide 1 (P = 0.042) responses were observed. Paper-10827981.
In addition, literature on the gastrointestinal hormones glucagon-like-peptide 1, apolipoprotein A-IV and peptide YY, and how they may act to regulate satiety, is described. Paper-10136410.
The tumor cells revealed argyrophilia, and were positive for peptide tyrosine tyrosine ( PYY) in the cytoplasm and for CEA in part of the luminal surface. Paper-6859071.
While obese subjects have appropriate reductions in orexigenic ghrelin, other gut-hormone disturbances may contribute to obesity such as reduced anorexigenic PYY and PP. Paper-12157731.
The most well studied in this regard are cholecystokinin ( CCK), pancreatic polypeptide, peptide YY, glucagon-like peptide-1 ( GLP-1), oxyntomodulin and ghrelin. Paper-12136054.
STUDY DESIGN: Rat pancreatic acinar cells were treated with recombinant TNF-alpha (200 ng/mL); PYY (3-36; 500 pM) was added 30 minutes post- TNF-alpha treatment. Paper-11829088.
Endopeptidase-24.11 ( neutral endopeptidase; enkephalinase) metabolizes PYY efficiently, with a major site of hydrolysis at the Asn29-Leu30 bond, an inactivating cleavage. Paper-8077015.
The aim of the present study was to investigate the mechanisms of the peptide YY effect on vasoactive intestinal peptide (VIP)-stimulated jejunal net water flux in the rat. Paper-1217565.
The binding was blocked only by unlabeled NPY but not by NPY-related peptides i.e. peptide YY, pancreatic polypeptide (avian and human), nor by neurotensin. Paper-5164327.
We suggest that dipeptidyl peptidase IV might be involved in the degradation of neuropeptide Y and peptide YY to N-terminal truncated neuropeptide Y(3-36) and peptide YY(3-36). Paper-7852140.
By Northern blot and reverse transcription polymerase chain reaction analyses, PYY mRNA was expressed in a complete form as detected in normal human colon mucosa. Paper-1738141.
Neuropeptide Y ( NPY), peptide YY ( PYY), and pancreatic polypeptide ( PP) are structurally related peptides found in all higher vertebrates. Paper-426509.
After VIP, the PYY EC50 values (in nM) were 18.6 in Y1-4, 8.0 in Y1-7 and 52.5 in Y1-16 hPP (1 microM) produced only small and transient responses in each transfected cell type. Paper-844401.
Plasma concentrations of gastrin, neurotensin, peptide YY ( PYY), pancreatic polypeptide ( PP), motilin and glucose were monitored before and after meals. Paper-1021727.
Substance P, neurokinin A ( NKA), calcitonin gene-related peptide ( CGRP), vasoactive intestinal peptide ( VIP), and peptide YY ( PYY) were tested. Paper-7849678.
Plasma Acrp30 and PYY concentrations were determined with radioimmunoassays during a 22-day period of fasting, which led to a 20.3% reduction in body mass of the animals (n=32). Paper-10755340.
This pathway further requires protein kinase C with EGFR TK inhibition blocking PYY-induced protein kinase Cepsilon (PKCepsilon) translocation to the cell membrane. Paper-8637514.
In obese unoperated patients, the density of PYY and secretin cells was decreased compared with the JIB-patients and the density of the GIP cells compared with both other groups. Paper-9954794.
Phospho- PYY potently inhibits forskolin-stimulated cAMP accumulation in SK-N-MC cells with an IC(50) value of 0.5 nM compared to 0.15 nM for non-phosphorylated PYY. Paper-8707257.
Somatostatin, peptide YY, pancreatic polypeptide, glucagon, ghrelin, and leptin were described as potentially involved from studies mostly performed on animals. Paper-12853378.
Whereas rat and human PP1 bind PP with the same affinity, the rat receptor has much lower affinity than its human ortholog for peptide YY and neuropeptide Y. Paper-560349.
Cell bodies and nerve fibres immunoreactive to PP, PYY, VIP, SP and FMRFamide are present throughout the CNS; the distributions of PHI and SRIF were more restricted. Paper-6819235.
Fasting ghrelin and resistin, and postprandial GLP-1 and PYY were measured.RESULTS: Mean BMI reduction was 4.8, 9.5, 15.4 and 20.1 kg/m(2) respectively at 1, 3, 6 and 12 months. Paper-12286203.
To investigate the influence of maldigestion on PYY, we determined plasma PYY levels in patients with celiac disease under basal conditions and in response to intraduodenal fat. Paper-9094793.
Saturable 125I-porcine PYY binding sites in all regions of the dogfish brain closely resembled the mammalian Y1 NPY receptor subtype in specificity for these substances. Paper-612190.
Neuropeptide Y ( NPY) receptors type 1 (Y1), type 2 Y2) and type 5 (Y5) were tested for their kinetic properties to bind radiolabeled NPY or PYY. Paper-11533772.
The 36-amino acid peptide, neuropeptide Y ( NPY), is a member of a peptide family that includes the endocrine peptides, peptide YY ( PYY), and pancreatic polypeptide ( PP). Paper-548218.
Venom dipeptidyl peptidase IV-like enzymes probably also contribute to hypotension by destroying vasoconstrictive peptides such as Peptide YY, neuropeptide Y and substance P. Paper-9345136.
When transiently expressed in EBNA cells, the guinea pig