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Serum total renin after tubal sterilization. Paper-8874912.
Effect of autonomic hyperreflexia on plasma renin. Paper-2664435.
Renin release: beta 1- or beta 2-receptor mediated? Paper-4935324.
HinfI RFLP at the human renin ( REN) gene locus. Paper-6358815.
We now find that PPARgamma binds to the renin HRE. Paper-12917159.
There was no correlation between endothelin and active renin. Paper-423896.
The endothelin system and renin in human fetal membranes. Paper-11526623.
Thus, the increase in active renin was not mediated by endothelin. Paper-423896.
Human renin ( REN) gene locus: BglII, RsaI and TaqI RFLPs. Paper-5163814.
Cyclooxygenase-2 and macula densa control of renin secretion. Paper-8938010.
Is peroxisome proliferator-activated receptor-gamma a new "pal" of renin? Paper-12487696.
Renin and the juxtaglomerular apparatus in diabetic nephropathy. Paper-3059539.
Activation of plasma prekallikrein and inactive renin by puff adder venom. Paper-3660784.
Cardiac peptides and plasma renin activity in acute dilated cardiomyopathy. Paper-8709986.
A pepstatin-dextran conjugate as an inhibitor of proteinase-free human renin. Paper-3926743.
CBP and p300 in renin homeostasis: can they drive the fate? Paper-13747554.
We next crossed homozygous hAGT TGR from both strains with homozygous hREN TGR. Paper-2149890.
Expression of REN and FLJ10761 were also proportional to copy number. Paper-10208827.
Arterial and renal venous plasma renin activity was unaffected by adrenomedullin. Paper-8169603.
Atrial natriuretic peptide in normal and low renin essential hypertension. Paper-6841458.
Renin is an aspartyl protease that plays a key role in regulating blood pressure. Paper-5765458.
CD-68, a marker for macrophages, was applied to slides previously stained with renin. Paper-9222569.
Renin inhibits N-acetyl-D-glucosamine 2-epimerase ( renin-binding protein). Paper-8643659.
Infused unblocked and blocked radiolabeled hREN was distributed similarly in the hAGT TGR strains. Paper-2149890.
In addition, Cx40 mediates pressure feedback inhibition on renin synthesis in the kidney. Paper-12742889.
Multipoint linkage analysis placed LAMB2 between FY and the cluster including REN, DAF, and CR2. Paper-5813556.
Expression of local renin and angiotensinogen mRNA in cirrhotic portal hypertensive patient. Paper-9907390.
Basal gene expression for Ren1 and Cox-2 in ISIAH rats was much lower than in WAG rats. Paper-14542406.
Burn and trauma associated proteinuria: the role of lipid peroxidation, renin and myoglobin. Paper-5807744.
Neurohumoral factors, e.g., plasma renin activity and atrial natriuretic peptide, may also be relevant. Paper-7401768.
Hypertension in autosomal dominant polycystic kidney disease: is renin acquitted as a culprit? Paper-12000782.
The notion that AGT is merely a passive substrate reservoir for REN should be revised. Paper-2149890.
No effect of a BglI polymorphism at the renin ( REN) locus on blood pressure level or variability. Paper-181179.
In conclusion, prorenin and renin- induced ERK 1/2 activation are independent of angiotensin II. Paper-12750481.
Infused mouse REN, which cannot convert hAGT, had similar T1/2beta and MCR values in hAGT TGR. Paper-2149890.
In addition, a significant increase in plasma renin activity during LBNP was found in the HI responders only. Paper-1161795.
Immunohistochemistry demonstrated enrichment of HADHB in renin-producing renal juxtaglomerular cells. Paper-10165380.
Ischemia-induced brain damage is enhanced in human renin and angiotensinogen double-transgenic mice. Paper-14098860.
Plasma atrial natriuretic peptide, plasma renin activity, and plasma glucagon levels were also determined. Paper-1211772.
Alzheimer disease is not associated with polymorphisms in the angiotensinogen and renin genes. Paper-10727763.
Laparoscopic tubal sterilization caused no measurable changes in total renin secretion during one year follow-up. Paper-8874912.
Effects of extracorporeal shock wave lithotripsy on plasma concentrations of endothelin and renin in humans. Paper-423896.
GFAP-icREN mice express hREN primarily in the brain and at the same level of expression as GFAP-secreted prorenin. Paper-10828982.
The associations were confirmed in haplotype analysis for REN, AGTR1, and ACE in African Americans. Paper-9684402.
RESULTS: Large amounts of prorenin and renin were detected in all samples with 85% to 95% in the form of prorenin. Paper-1059618.
Renin-binding protein ( RnBP) is a highly specific renin inhibitor first isolated from porcine kidney. Paper-8643659.
Plasma active and inactive renin concentrations ( PARC and PIRC) were measured by immunoradiometric assay. Paper-6658743.
UKa was also elevated in the normal renin group (25.7 +/- 2.4 nkat/24 h) but to a significantly lesser degree. Paper-6473690.
Aspartic proteinases form a widely distributed protein superfamily including cathepsins, pepsins, renin and napsin. Paper-10455886.
Cultured mouse myeloma cells were transfected with expression vectors encoding the aspartyl proteinase, human renin. Paper-6236150.
Blood pressure in the hREN/ GFAP- hAGT mice was lowered after ICV, but not intravenous losartan. Paper-9046460.
Renin positive interstitial cells co-expressed CD-68 antigen identifying these cells as macrophages. Paper-9222569.
Re: Severe hypertension in a newborn associated with increased renin production by a hypoplastic kidney. Paper-4525005.
Responses of plasma catecholamine and plasma renin activity after glucagon stimulation in essential hypertension. Paper-3989203.
Urology: Very Selective Renal Vein Renin Determination in the Diagnosis of Segmental Renal Hypertension. Paper-13467932.
Peroxisome proliferator-activated receptor-gamma is involved in the control of renin gene expression. Paper-12526649.
Novel mass spectrometric methods for evaluation of plasma angiotensin converting enzyme 1 and renin activity. Paper-10974158.
Aliskiren did not inhibit renin and prorenin- induced ERK 1/2 phosphorylation and kinase activity. Paper-12750481.
Renal damage is not improved by blockade of endothelin receptors in primary renin-dependent hypertension. Paper-10197159.
Repeated determinations showed high plasma renin activity and plasma erythropoietin activity within the detectable range. Paper-2909679.
A novel assay was developed for measurement of renin and angiotensin-converting enzyme (ACE) activity in plasma. Paper-10974158.
Peripheral blood samples were analyzed for active renin and endothelin before, and immediately, 1, 3 and 5 days after ESWL. Paper-423896.
We conclude that increased AGT concentrations decrease REN MCR and increase REN T1/2beta. Paper-2149890.
In the hypertensive patient renin collections from the vena cava and the renal vein of the solitary kidney were normal. Paper-4307892.
The alpha 1 blockers maintain cardiac output and blood flow to vital organs, and they do not affect renin release. Paper-6927859.
Plasma renin, erythropoietin and chorionic gonadotropin levels were evaluated in 57 patients with renal adenocarcinoma. Paper-2693347.
Plasma renin, erythropoietin and chorionic gonadotropin levels were evaluated in 57 patients with renal adenocarcinoma. Paper-2567259.
Taken together, these data strongly suggest that Pit-1 activates pituitary renin gene expression. Paper-7566329.
Regional chromosomal assignment of human renin gene to 1q12----qter and use in linkage studies in Charcot-Marie-Tooth disease. Paper-5733143.
The tissue-specific expression patterns of REN and FLJ10761 were retained in transgenic mice containing PAC160. Paper-10208827.
In contrast to angiotensin II- ERK signaling, renin and prorenin signaling did not involve the epidermal growth factor receptor. Paper-12750481.
We report a case of erythrocytosis due to elevated serum erythropoietin with a renin secreting juxtaglomerular cell tumor. Paper-6241544.
Effect of hypovolemia, infusion, and oral rehydration on plasma electrolytes, ADH, renin activity, and +Gz tolerance. Paper-2729783.
In summary, PPARgamma was identified as a novel intracellular mediator involved in the upregulation of renin transcription. Paper-12526649.
Superoxide contributes to vascular dysfunction in mice that express human renin and angiotensinogen. Paper-9170543.
The inhibitor was shown to be alpha-1 anti-trypsin and the effect in vitro on the renin activity was examined. Paper-2484438.
Atrial natriuretic peptide increases microvascular blood flow and macromolecular escape during renin infusion in the hamster. Paper-6682962.
Plasma renin activities (resting PRA, post-dialysis delta PRA) were studied in 61 patients under chronic dialysis treatment. Paper-3362672.
Plasma renin activity was nearly equal in three extrarenal sampling sites (antecubital vein, aorta, and lower inferior vena cava). Paper-3715071.
When used in studies of 12 informative families, no linkage could be found between the renin gene and Charcot-Marie-Tooth disease. Paper-5733143.
Concentrations of both atrial natriuretic peptide and renin showed significant inverse relations with serum sodium concentrations. Paper-5153481.
We genotyped 25 single-nucleotide polymorphisms in the renin-angiotensin system genes ACE, AGT, AGTR1, and REN. Paper-9684402.
Ren, Aldo and AVP, which were similar in both groups, were reduced in H7, but were higher in RSL2 (rest or exercise). Paper-9628958.
No conversion of this inactive high molecular weight renin into the active, 44,000 mol wt form of renin was observed. Paper-4639256.
Exaggeration of focal cerebral ischemia in transgenic mice carrying human Renin and human angiotensinogen genes. Paper-13591700.
AIM: To investigate the expression of local renin and angiotensinogen mRNA in cirrhotic portal hypertensive patients. Paper-9907390.
Activation and characterization of inactive big renin in plasma of patients with diabetic nephropathy and unusual active renin. Paper-3684385.
Gene expression studies revealed that renin and endothelin-1 were regulated by PPARgamma in Calu-6 cells. Paper-12948144.
Plasma prolactin in normal and hypertensive subjects: relationships with age, posture, blood pressure, catecholamines, and renin. Paper-3694675.
Thus acid activation of inactive renin depends on plasma prekallikrein, whereas the action of trypsin is independent of prekallikrein. Paper-3426159.
Angiotensinogen concentrations and renin clearance : implications for blood pressure regulation. Paper-2149890.
In both normal subjects and the normal renin essential hypertensives, plasma prolactin was significantly higher in females than in males. Paper-5106476.
Impaired endothelial function in transgenic mice expressing both human renin and human angiotensinogen. Paper-2138907.
The production of renin by the tumor cells was confirmed by demonstration of specific renin mRNA by in situ hybridization ( ISH). Paper-8013824.
Using bladder distention to produce the autonomic hyperreflexia, renin determinations were made during and after the hypertensive episode. Paper-2664435.
Surprisingly, we found that PPARgamma targets a palindromic repeat with a 3-bp spacer (Pal3) in the proximal human renin promoter. Paper-12526649.
Plasma cathepsin D isoforms and their active metabolites increase after myocardial infarction and contribute to plasma renin activity. Paper-11499858.
Renal and antihypertensive effects of neutral endopeptidase inhibition in transgenic rats with an extra renin gene. Paper-793239.
Vascular damage (VD), glomerular sclerosis (GS), renin ( PRA) and blood pressure were assessed in 50 patients with Berger's nephropathy. Paper-4520883.
HADHB, HuR, and CP1 bind to the distal 3'-untranslated region of human renin mRNA and differentially modulate renin expression. Paper-10165380.
Increased blood pressure in transgenic mice expressing both human renin and angiotensinogen in the renal proximal tubule. Paper-10221291.
Therefore, we believe that renin and erythropoietin determinations may be of value as biochemical tumor markers in renal adenocarcinoma. Paper-2693347.
Therefore, we believe that renin and erythropoietin determinations may be of value as biochemical tumor markers in renal adenocarcinoma. Paper-2567259.
The human renin Pal3 sequence was found to selectively bind PPARgamma and the retinoid X receptor-alpha from Calu-6 nuclear extracts. Paper-12917159.
MATERIALS & METHODS: Functional polymorphisms were selected from five candidate genes: CYP27B1, CYP24A1, VDR, REN and ACE. Paper-14560966.
2 Although experimental renin regulation appears to be a beta 2-receptor function, clinical studies suggest that in man it is a beta 1 effect. Paper-3212007.
We tested the hypothesis that this long catalytic cycle might indicate an influence of AGT concentrations on REN clearance. Paper-2149890.
Renin ( REN) requires seconds to convert angiotensinogen ( AGT) to angiotensin I. Paper-2149890.
PPARgamma knockdown paradoxically did not attenuate the stimulation of the endogenous renin gene expression by rosiglitazone. Paper-12917159.
Digests of DNA were prepared from leucocytes and RFLPs were determined using Southern blotting analysis with REN and ANP gene probes. Paper-48756.
The Pal3 promoter sequence is critical for the regulation of human renin gene transcription by peroxisome proliferator-activated receptor-gamma. Paper-12917159.
Co-transfection of human PC5 and human prorenin expression vectors in cultured GH4C1 cells led to secretion of active renin. Paper-746328.
Renin and atrial natriuretic peptide restriction fragment length polymorphisms: association with ethnicity and blood pressure. Paper-48756.
Neutral endopeptidase inhibition potentiates the effects of natriuretic peptides in renin transgenic rats. Paper-920644.
In homozygous Ren2 rats, renal damage was ameliorated by a nonhypotensive dose of an AT(1)-RA and, similarly, by blockade of ERK or p38. Paper-10052349.
Erythropoietin was raised in 63 per cent of patients and was more sensitive than renin in indicating the presence of renal adenocarcinoma. Paper-2693347.
Erythropoietin was raised in 63 per cent of patients and was more sensitive than renin in indicating the presence of renal adenocarcinoma. Paper-2567259.
Similarly, a deficiency of PPARgamma did not attenuate the activation of the minimal human renin promoter, which contains the endogenous Pal3 motif. Paper-12917159.
A case is presented of renal artery stenosis causing renin-dependent hypertension 11 1/2 years after irradiation for Wilms tumor. Paper-2878733.
We hypothesized that MI would also result in cardiac release of cathepsin D, a ubiquitous lysosomal enzyme with high renin sequence homology. Paper-11499858.
Activation of plasma prorenin by plasminogen activators in vitro and increase in plasma renin after stimulation of fibrinolytic activity in vivo. Paper-4543956.
A mitogen-activated protein kinase kinase 1/2 inhibitor inhibited both renin and prorenin- induced ERK 1/2 phosphorylation. Paper-12750481.
Cathepsin D release from damaged myocardial tissue could contribute to angiotensin formation by acting as an enzymatic alternate to renin. Paper-11499858.
COX-2 metabolites have been implicated in mediation of renin release, regulation of sodium excretion and maintenance of renal blood flow. Paper-10745846.
Factor VII, apolipoprotein E and two renin polymorphisms were differentially frequent in patients with evidence of CS compared with non-CS patients. Paper-13003734.
As anticipated, renin and renin mRNA were also detected in the HLA-DR negative cells, more than 80% of which stained with specific antiserum to PRL. Paper-198395.
The renin ( REN) gene is a good candidate that could underlie an individual's genetic susceptibility to human essential hypertension (EHT). Paper-2101680.
Endogenous or pharmacological PPARgamma agonists (unsaturated fatty acids and thiazolidinediones, respectively) stimulated renin gene expression. Paper-12526649.
Analysis of the distribution of the human signal among the hybrids confirms the localization of the renin gene ( REN) to human chromosome 1. Paper-6279905.
The finding of big renin may indicate the presence of certain renin-secreting renal tumors or other renal disorders, especially diabetic nephropathy. Paper-2462990.
Quantitative study of human blood alpha-1-antitrypsin, alpha-2-macroglobulin and inter-alpha-trypsin-inhibitor with respect to plasma renin activity. Paper-4325433.
Angiotensinogen ( AGT) is mainly expressed in glial cells in close proximity to renin-expressing neurons in the brain. Paper-11472865.
We conclude that dual production of renin and angiotensinogen in the renal proximal tubule can result in a systemic increase in arterial pressure. Paper-10221291.
The concentration of inactive renin on the affected side was significantly lower than that on the non- affected side and in the inferior vena cava. Paper-3396930.
Recombinant HADHB bound specifically to the 3'-UTR of REN mRNA, as did the known mRNA stabilizers HuR and CP1 (poly(C)-binding protein-1). Paper-10165380.
Glial-specific ablation of angiotensinogen lowers arterial pressure in renin and angiotensinogen transgenic mice. Paper-11472865.
There was no correlation between sodium intake and plasma prolactin, nor was there any apparent correlation between prolactin and plasma renin activity. Paper-2934797.
CONCLUSION: In children, active renin determination is preferable to PRA determination because of methodological advantages and a smaller sample volume. Paper-827153.
Similarly, transition from slow-wave sleep (SWS) to light sleep (LS) is affected by a "hormone-time" interaction for cortisol and renin, but not GH. Paper-13685796.
The effect of laparoscopic tubal sterilization by Hulka or Filshie clips on serum total renin levels was evaluated in 33 healthy, regularly menstruating women. Paper-8874912.
Statistical modeling of pairwise interactions was done using two-way ANOVA between polymorphisms in the ETNK2, RENIN, ACE, PAI-1, t-PA, and AGT genes. Paper-15671760.
Immunoprecipitation and reverse transcription-PCR of Calu-6 extracts confirmed that HADHB, HuR, and CP1 each associate with REN mRNA in vivo. Paper-10165380.
In the brain of GFAP- hREN and SYN- hREN mice, hREN protein was observed almost exclusively in astrocytes and neurons, respectively. Paper-9169502.
We have studied a series of 19 primary renal cell carcinomas using an antibody to pure human renin and the indirect PAP technique. Paper-4539514.
Despite the close localization of KISS1, REN, and FLJ10761, they each exhibit distinct, yet overlapping tissue-specific expression profiles in humans. Paper-10208827.
Because of the differing specificities of polyclonal antisera, sera raised in two laboratories against human renin purified from different sources were employed. Paper-4613728.
In the present study we investigate whether REN (BglI), AGT (M235T), ACE (A245T, Indel), and AGTR1 (A1166C) are associated with breast cancer. Paper-15953987.
We conclude that there are sequences in and around the renin and ETNK2 loci which act as boundaries between neighboring genes which insulate them from each other. Paper-12927863.
The ISH was negative for renin mRNA at these sites, indicating that renin positivity was due to an uptake of renin rather than to renin production. Paper-8013824.
PPARgamma-dependent regulation of adenylate cyclase 6 amplifies the stimulatory effect of cAMP on renin gene expression. Paper-15482124.
A significantly positive correlation was observed between plasma renin activity and the plasma prolactin level in male essential hypertensives, but not in females. Paper-5106476.
Their salt appetite correlated with symptoms of salt wasting, namely, plasma renin activity, plasma K(+), and urine Na(+) and (inversely) with blood pressure. Paper-10989031.
The number of transgenic fetuses in each pool was determined by human renin-specific polymerase chain reaction of DNA purified from placenta or tail biopsies. Paper-7636956.
Seven-week-old homozygous Ren2 rats were treated with low-dose AT(1)-RA candesartan, ERK inhibitor tyrphostin, or p38 inhibitor SB239063 for 4 weeks. Paper-10052349.
Immunohistochemical profile of the human placenta. Studies on localization of prolactin, human chorionic gonadotropin, human placental lactogen, renin and oxytocin. Paper-5857232.
Lateralization of renin secretion as assessed by the PRA ratio and the renin secretion index was found in the majority of patients (66% and 88%, respectively). Paper-5148963.
AT3, REN, CR2, and GNB1 mapped to BTA 16, PFKM to BTA 5, AMY1A and NRAS to BTA 3, FGR and FUCA1 to BTA 2, and ACTA1 to BTA 28. Paper-143824.
In 2 patients (1 with APA, 1 with IAH) PRA was constantly undetectable (less than 0.2 ng/ml . 18 h) and in 2 patients with APA a fixed secretion of renin was observed. Paper-3280908.
In hypertensive patients the proportion of the more basic renin forms in the hepatic vein was significantly decreased in comparison with the infrarenal vena cava. Paper-6633438.
De novo CML patients had increased ACE, angiotensinogen and renin mRNA levels and these expression levels decreased following administration of imatinib. Paper-13998686.
The specificity of immunofluorescence was proven by exclusion of cross reactivity with pepsin, cathepsin-D, acid erythrocyte proteinase and porcine renin. Paper-4489651.
PPARgamma agonists also stimulated renin gene expression in cultured native juxtaglomerular cells, which are the main source of renin in vivo. Paper-12526649.
Prorenin and renin- induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide. Paper-12750481.
METHODS: The expression of local renin and angiotensinogen mRNA in the liver, splenic artery and vein of PH patients was detected by RT-PCR analysis. Paper-9907390.
Severe renin- mediated hypertension was noted in 2 children as a result of selective renal damage from vesicoureteral reflux during the early years of life. Paper-2825266.
1. Urinary sodium excretion and plasma renin activity have been measured in a group of persons with untreated mild hypertension and in a control normotensive group. Paper-2267205.
Genetic and gene expression studies implicate renin and endothelin-1 in edema caused by peroxisome proliferator-activated receptor gamma agonists. Paper-12948144.
Symposium on hypertension: Part II. Renin profiling and drug therapy, childhood hypertension, prorenin, the physiology of renin secretion. Introduction. Paper-2550701.
Double transgenic mice expressing both the hREN gene and SYN- hAGT transgene exhibited normal BP and water intake but had an increased preference for salt. Paper-9180341.
The expression of genes for renin ( Ren1) and cyclooxygenase ( Cox-2) was evaluated in renal tissue of ISIAH and WAG rats (normotensive control). Paper-14542406.
Rats harboring the human renin and angiotensinogen genes (dTGR) feature angiotensin (ANG) II/hypertension-induced cardiac damage and die suddenly between wk 7 and 8. Paper-13369320.
Renal endothelin-1 mRNA expression and proteinuria (4.1-fold) were significantly elevated in Ren2 compared with SD rats ( P < 0.05, respectively). Paper-10197159.
Neither the human renin HRE nor the consensus PPRE was sufficient to attain the maximal stimulation of renin promoter activity by the PPARgamma agonist rosiglitazone. Paper-12917159.
Upon decreasing HADHB mRNA with RNA interference, renin protein and mRNA stability increased, whereas RNA interference against HuR caused these to decrease. Paper-10165380.
Prorenin, a precursor of renin, was measured in sera from normal subjects and type 2 diabetic patients, using a newly developed antibody-activating direct enzyme kinetic assay. Paper-11608375.
There was no significant difference between the liver, splenic artery and vein in the expression of local renin or local angiotensinogen mRNA in PH group, (P<0.05). Paper-9907390.
Cellular expression of renal, cardiac and pulmonary inducible nitric oxide synthase in double-transgenic mice expressing human renin and angiotensinogen genes. Paper-14547917.
1. Hypertensive mice expressing the human renin ( REN) and angiotensinogen ( AGT) genes are used as a model for human hypertension. Paper-14547917.
In U937 cells, we found that both human renin and prorenin induced a long-lasting ERK 1/2 phosphorylation despite angiotensin II type 1 and 2 receptor blockade. Paper-12750481.
Association of the renin gene polymorphism, three angiotensinogen gene polymorphisms and the haplotypes with essential hypertension in the Mongolian population. Paper-15321559.
Our data suggest that in addition to its direct effect on renin gene transcription, PPARγ "sensitizes" renin gene to cAMP via trans-activation of AC6 gene. Paper-15482124.
Schweda et al. offer exciting data demonstrating that connexin45, a connexin with different biophysical properties, can replace connexin40 functions related to the control of renin. Paper-13617616.
AC6 knockdown decreased basal renin mRNA level and attenuated the maximal PPARγ-dependent stimulation of the cAMP-induced renin gene expression. Paper-15482124.
Low PRA and active renin (AR) may be accompanied by low inactive renin (IR), indicating impaired renin production, or by normal or elevated IR, suggesting defective conversion to AR. Paper-3965561.
The role of radiology in screening and diagnosis is discussed with special attention to renal vein sampling for renin assay ( RVR) and digital subtraction angiography (DSA). Paper-6306419.
In contrast, the human renin Pal3 element mediates both the full PPARgamma-dependent activation of transcription and the PPARgamma-driven basal renin gene transcription. Paper-12917159.
We generated double-transgenic mice expressing human renin ( hREN) from a neuron-specific promoter and human AGT ( hAGT) from its own promoter (SRA mice) to emulate this expression. Paper-13164481.
Immunohistochemistry results were as follows: vimentin (positive), renin (weakly positive), smooth muscle actin (focal immunoreactivity), and cytokeratin (negative). Paper-11999829.
However, when the human renin Pal3 site was replaced by the consensus PPRE sequence, PPARgamma knockdown abrogated the effect of rosiglitazone on renin promoter activity. Paper-12917159.
Several functional binding sites for CTCF, a mammalian insulator protein, were identified in and around the renin and ETNK2 loci by gel shift and chromatin immunoprecipitation. Paper-12927863.
The effect of acute plasma volume change in humans on serum erythropoietin [EPO]s, plasma active renin [ REN] and plasma aldosterone [ ALDO] concentrations was examined. Paper-669614.
These I3C-induced changes in renal haemodynamics, PRA and kidney Ang II levels were more pronounced in Cyp1a1- Ren2 rats with malignant hypertension. Paper-14713377.
RESULTS: In the upright posture, systemic hemodynamics, FA blood flow index, plasma atrial natriuretic peptide level, and plasma renin activity level were similar in patients and controls. Paper-1211772.
The suppression of renin secretion from the ischemic kidney either by nephrectomy or by revascularization, joins with normalization either of peripheral PRA or of blood pressure. Paper-2992861.
Double-transgenic mice expressing the hREN gene and the GFAP- hAGT transgene exhibited a 15-mm Hg increase in blood pressure and an increased preference for salt. Paper-9046460.
However, UMOD, REN or HNF-1β mutations are found in only approximately 45% of FJHN probands, indicating the involvement of other genetic loci in approximately 55% of probands. Paper-15599641.
It has been shown that renin secretion is stimulated by endothelin, a recently discovered peptide with strong vasoconstrictive properties and stimulating effects on renin secretion. Paper-423896.
We investigated renin/prorenin ratios in untreated GHD patients (n=31) and in a group of GHD patients treated with GH (n=23) and compared both groups to a group of 59 normal control subjects. Paper-11035355.
METHODS: Sixteen patients undergoing posterior spinal fusion using isoflurane and fentanyl (n = 8) or sufentanil (n = 8) had renin, aldosterone, ADH and ANF measurements. Paper-10881949.
In brain, transcription of hREN occurs from an alternative upstream promoter, causing translation to initiate within exon-II and potentially generating an intracellular form of active renin. Paper-9189546.
Resveratrol induces mitochondrial biogenesis and ameliorates Ang II-induced cardiac remodeling in transgenic rats harboring human renin and angiotensinogen genes. Paper-15115222.
Both GFAP- hREN and SYN- hREN mice exhibited the highest hREN mRNA expression in the brain and had undetectable levels of hREN protein in the systemic circulation. Paper-9169502.
Heterozygous offspring from the low hAGT TGR strain had plasma REN activity, hREN concentration, and rat AGT values that were no different from those of their parents. Paper-2149890.
We assessed circulating renin and cathepsin D from both control and MI patient plasma (7-20 hours after MI) using shallow gradient focusing that allowed for independent measurement of both enzymes. Paper-11499858.
4. Highly purified tissue (pancreatic) kallikrein, in a concentration of less than 2 X 10(-8) mol/l, activates inactive renin that has been isolated from plasma by ion-exchange chromatography. Paper-3426159.
Therefore, our objective was to determine whether the genes for placental renin ( REN) and maternal angiotensinogen ( AGT) interact to influence the risk of preeclampsia. Paper-15293697.
These RFLPs were used to study the linkage relationships of LAMB2 to four other genes on lq: Duffy (FY), renin ( REN), decay accelerating factor (DAF), and complement receptor 2 ( CR2). Paper-5813556.
Included in the group of 9 patients were those with polycystic kidneys, staghorn calculi, renin-related renal hypertension, chronic pyelonephritis and persistent vesicoureteral reflux. Paper-4458994.
Renin gene I/ D polymorphism is associated with EH, whereas AGT gene M235T, A-6G, and A-20C polymorphisms and the haplotypes are not associated with EH in the Mongolian population. Paper-15321559.
CONCLUSIONS: Our study revealed RAS genes, ACE and AGT-M235T but not AGT-T174M, AGTR1 or REN genotypes, as contributing factors for DN in type 2 diabetes mellitus in Chinese. Paper-10594314.
The binding ability of hPRR expressed in the haemolymph and fat body with renin or prorenin was analysed by ELISA and surface plasmon resonance using a biosensor respectively. Paper-12739959.
In renovascular patients suppression or renin secretion from the contralateral kidney was always observed: otherwise in patients with essential hypertension both kidneys contribute to peripheral PRA. Paper-2992861.
Transfection of a Pit-1 expression construct into HeLa cells, where activity of the human renin promoter is low, stimulates expression of cotransfected renin-luciferase constructs. Paper-7566329.
As the renin gene is negatively regulated by calcium in the same way as the parathormone ( PTH) gene, we hypothesized that a similar molecular transcriptional mechanism could be involved. Paper-10015439.
The purpose of the study is to explore the association of a new genetic marker of renin gene, and AGT gene M235T, A-6G, and A-20C polymorphisms and their haplotypes with EH in the Mongolian population. Paper-15321559.
The relationship between blood pressure, REN and ANP gene RFLPs was tested in a population of black Afro-Caribbean and white European subjects sampled randomly from family practice registers. Paper-48756.
Maternal angiotensinogen ( AGT) haplotypes, fetal renin ( REN) haplotypes and risk of preeclampsia; estimation of gene-gene interaction from family-triad data. Paper-15293697.
These results indicate that renin is an inhibitor of GlcNAc 2-epimerase, and the renin- RnBP heterodimer HMW renin is an inactive form of both renin and GlcNAc 2-epimerase activities. Paper-8643659.
CONCLUSIONS: The locus identified in this study for familial dilated cardiomyopathy, 1q32, is rich in candidate genes, such as MEF-2, renin, and helix loop helix DNA binding protein MYF-4. Paper-438719.
Thus, to investigate whether RB is involved in the regulation of renin gene expression, we examined the effects of RB on transcriptional activity of the mouse renin (Ren-1C) promoter. Paper-1079895.
The effect of hepatic degradation on renin forms was assessed in hepatic vein plasma in comparison with infrarenal vena cava plasma in hypertensive patients during renal vein renin studies. Paper-6633438.
RECENT FINDINGS: Apart from fluid overload and renin activation, hypertensive patients with autosomal dominant polycystic kidney disease also have increased sympathetic activity, regardless of renal function. Paper-9312104.
3. Inactive renin can also be activated by exposure of plasma to exogenous trypsin, and in normal plasma the quantities of inactive renin that are activated after acidification and with trypsin are identical. Paper-3426159.
We estimated relative risks (RR) conferred by maternal AGT and fetal REN haplotypes using HAPLIN, a statistical software designed to detect multi-marker transmission distortion among triads. Paper-15293697.
Moreover, 24 hours after nephrectomy, human plasma renin fell to very low levels, indistinguishable from those of nontransgenic littermates, indicating that their circulating hREN is of renal origin. Paper-1702327.
MATERIALS AND METHODS: In a prospective study of 48 normotensive patients undergoing ESWL for renal stones the influence of high energy shock waves on plasma endothelin and active renin was analyzed. Paper-423896.
Four patients with paroxysmal hypertension related to spinal cord injury (autonomic hyperreflexia) were studied to determine if the plasma renin became elevated in relation to a sympathetic stimulus. Paper-2664435.
Nevertheless, several inhibitors including those targeting renin, BACE1 and gamma-secretase are in clinical or preclinical development, and some other aspartic proteases are discussed as potential drug target. Paper-13121849.
Fluorescence-activated cell sorter analysis showed that, although fluorescein isothiocyanate-labeled HRP bound to U937 cells, HRP did not inhibit renin or prorenin- induced ERK 1/2 activation. Paper-12750481.
A 19-year-old man with moyamoya disease was diagnosed as having renovascular hypertension, based on stenosis of the proximal portion of the right renal artery with elevated plasma renin activity. Paper-9080498.
In order to determine the influence of proximal 5'-flanking DNA of the human renin gene ( REN) in cells that express human renin, transient expression analyses were carried out in chorio-decidual cells. Paper-135369.
A linkage analysis using the backcross progenies confirmed the assignment of renin locus ( REN) on linkage group (LG) X at a site between FH ( fumarate hydratase) and PEPC (peptidase) loci. Paper-64453.
For breast cancer there are three reports that include the angiotensin II receptor, subtype 1 (AGTR1), only one for angiotensinogen ( AGT) and none for renin gene ( REN). Paper-15953987.
The present study, while confirming the ability of the denervated kidney to handle sodium normally, also suggests that atrial natriuretic peptide could assume a crucial role in regulating renin secretion. Paper-8066445.
To identify other FJHN loci, we performed a single nucleotide polymorphism (SNP)-based genome-wide linkage analysis, in six FJHN families in whom UMOD, HNF-1β and REN mutations had been excluded. Paper-15599641.
We conclude that a change in Cox-2 gene expression after short-term water deprivation serves as a reliable criterion for functional strain of the renal renin system in hypertensive ISIAH rats. Paper-14542406.
RESULTS: During the 20-week observation period 35% of untreated Ren2, 30% of Ren2- ETA/ B, 50% of Ren2- ETA, and 83% of Ren2-AT1 animals survived compared with 100% of SD rats. Paper-10197159.
During renin infusion, topical ANP (50 ng/ml) produced transient arteriolar vasodilation, and increased 51Cr-EDTA clearance (+35%), RVC (+58%) and FITC-Dx-150 clearance (+54%), without affecting systemic pressure. Paper-6682962.
To assess the role of inactive renin in hypertensive patients, active, inactive and total renin concentrations (ARC, IRC and TRC) were measured in 37 patients with hypertension of various etiologies. Paper-4843393.
Four-week-old double transgenic rats harboring human renin and human angiotensinogen genes (dTGR) were treated for 4 weeks either with SIRT1 activator resveratrol or SIRT1 inhibitor nicotinamide. Paper-15115222.
Proteinuria was normalized to SD control levels in Ren2-AT1 ( P < 0.05) but increased further in Ren2- ETA (7.7-fold) and Ren2- ETA/ B (15-fold) ( P < 0.05, respectively). Paper-10197159.
The presence of an MboI site in an RFLP in the renin gene and the Thr at the Met/Thr polymorphism at codon 235 (M235T) of the angiotensinogen gene have been reported to be associated with hypertension. Paper-10727763.
Using surface-enhanced laser desorption/ionization time of flight mass spectrometry ( SELDI-TOF-MS) with a ProteinChip Array technology, plasma renin and ACE1 could be measured in <0.5 microL of plasma. Paper-10974158.
The effects of Atrial Natriuretic Peptide ( ANP) on microvascular hemodynamics and macromolecular permselectivity were studied in the hamster cheek pouch under resting conditions and during intravenous renin infusion. Paper-6682962.
The lower PRA appears to be due to a reduction in the rate of secretion of renin but the exact mechanistic events underlying such differences in renin release between blacks and whites are still not fully understood. Paper-8721527.
We report here the results of linkage studies using five chromosome 1 markers--Duffy (Fy), antithrombin III (AT3), renin ( REN), beta-nerve growth factor (NGFB), and salivary amylase (AMY1)--in 16 CMT1 pedigrees. Paper-6102017.
CONCLUSION: In normal subjects the expression of local renin and angiotensinogen mRNA was organ specific, but with increase of the expression of LRAS, the organ-specificity became lost in cirrhotic patients. Paper-9907390.
As a key enzyme of the renin-angiotensin-aldosterone system, the renin gene ( REN) is a good candidate quantitative trait locus that may be implicated in the molecular etiology of essential hypertension. Paper-1670686.
The renin-angiotensin system is upregulated in the donor and downregulated in the recipient's kidneys, while paradoxically raised renin levels in the recipient may contribute to raised afterload along with endothelin. Paper-11220183.
Antibodies to angiotensin AT(1) receptor ( AT1), angiotensinogen ( ANG), renin ( REN), angiotensin converting enzyme (ACE) and angiotensin II ( AII) were used. Paper-8897919.
We previously reported the development and characterization of transgenic mice containing a large 160-kb P1 artificial chromosome (PAC) encompassing the renin ( REN) locus from human chromosome 1. Paper-10208827.
Time course studies showed that renin was first synthesized in a high molecular weight form, 55,000 mol wt, i.e., 10,000 mol wt higher than that of active renin, and was then converted into a 44,000-mol wt form. Paper-4639256.
Thus, the human renin Pal3 site appears to be critical for the PPARgamma-dependent regulation of gene expression by mediating maximal transcription activation, particularly at the low cellular level of PPARgamma. Paper-12917159.
No change in TAME esterase or renin activity occurred after addition of kaolin to acid-treated plasma deficient in Hageman factor; however, both enzymatic activities increased slightly in acidified prekallikrein-deficient plasma. Paper-3717486.
This study aimed to assess expressions of the RAS components, renin, angiotensinogen and angiotensin-converting enzyme (ACE), during imatinib mesylate treatment of patients with chronic myeloid leukaemia (CML). Paper-13998686.
Subjects were genotyped at the angiotensinogen M235T, angiotensin-converting enzyme I/ D, aldosterone synthase C-344 T, renin, angiotensin II type 1 receptor, and adducin loci. Paper-10148150.
Constructs containing renin DNA to residue +13, i.e., which retained the REN promoter, all displayed very low CAT activities, consistent with negative cis-acting control within the -149 to +13 region. Paper-7014094.
However, TGR offspring with high hAGT values had massively elevated plasma REN activity and hREN concentration as well as elevated blood pressure, even though both the hREN and rREN genes are downregulated. Paper-2149890.
An investigation of restriction fragment length polymorphisms ( RFLPs) and association with blood pressure was carried out for the candidate genes coding for renin ( REN) and atrial natriuretic peptide ( ANP). Paper-48756.
Hormonal values that had a significant correlation with intraoperative diuresis were: renin at 0.5 h (r2 = 0.26, P = 0.04), aldosterone at 0.5 h (r2 = 0.30, P = 0.03) and ANF at 0.5 h (r2 = 0.32, P = 0.02). Paper-10881949.
We tested whether human prorenin and renin induce extracellular signal-regulated kinase (ERK) 1/2 activation and whether the direct renin inhibitor aliskiren or the HRP inhibits the receptor. Paper-12750481.
However, if there is a concomitant diminution or absence of normal renin a state of apparent hyporeninemia exists, as we have observed in diabetic nephropathy; this may be associated with hypoaldosteronism and hyperkalemia. Paper-2462990.
STUDY DESIGN: Decidua and villous placental tissue were obtained from term and first-trimester human pregnancies, and concentrations of prorenin, active renin, prolactin, and human chorionic gonadotropin were measured. Paper-180596.
FJHN is genetically heterogeneous and due to mutations of three genes: uromodulin ( UMOD), renin ( REN) and hepatocyte nuclear factor-1beta (HNF-1β) on chromosomes 16p12, 1q32.1, and 17q12, respectively. Paper-15599641.
PV (measured by carbon monoxide rebreathing), plasma renin ( Ren), aldosterone ( Aldo), atrial natriuretic factor ( ANF) and arginine vasopressin ( AVP) were measured at rest and during exercise. Paper-9628958.
Yeast three-hybrid screening with the REN 3'-UTR as bait isolated HADHB (hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein) beta-subunit) as a novel REN mRNA-binding protein. Paper-10165380.
RESULTS: Analysis of the human renin proximal promoter led to the identification of a negative calcium response element (nCaRE), which is identical to the region of the PTH promoter and is involved in its repression by calcium. Paper-10015439.
The mechanism controlling cell-specific Ang II production in the brain remains unclear despite evidence supporting neuron-specific renin and glial- and neuronal-specific angiotensinogen ( AGT) expression. Paper-13164481.
CONCLUSIONS: These findings indicate that acetylcholine-induced relaxation of carotid artery is impaired selectively in mice made hypertensive by expression of human renin and human angiotensinogen. Paper-2138907.
CONCLUSION: Our results implicate a key role for renin and endothelin-1 in the edema caused by PPARgamma agonists and demonstrate how knowledge gained from pharmacogenetic studies can be applied in drug discovery. Paper-12948144.
The lysosomal hydrolase cathepsin B has been proposed as a prorenin processing enzyme based on reports of its co-localization with renin in the secretory granules of certain tissues and its ability to activate prorenin in vitro. Paper-1727241.
The significance is discussed of the susceptibility of cyprosin to inhibitors of human immunodeficiency virus proteinase and particularly of renin, some of which were found to have subnanomolar potencies against the plant enzyme. Paper-1888661.
Plasma prolactin was also significantly higher in the normal renin essential hypertensives than in normal subjects of both sexes, while no significant difference was found between the low renin group and normal subjects of either sex. Paper-5106476.
We found only weak evidence of an overall effect of fetal REN haplotypes and no support for our hypothesis that an effect of REN depended on whether the mother carried the C-T-A haplotype of AGT (p = 0.33). Paper-15293697.
We have developed a new assay method for GlcNAc 2-epimerase activity using a system of N-acyl-D-hexosamine oxidase coupled with peroxidase and employed this method to study the effects of renin on GlcNAc 2-epimerase activity. Paper-8643659.
Genetic clamping of renin gene expression induces hypertension and elevation of intrarenal Ang II levels of graded severity in Cyp1a1- Ren2 transgenic rats. Paper-14713377.
The aim of this survey was to investigate the association of the polymorphisms (angiotensin II type 1 [ AT1] receptor T174M and M235T, renin G2805A, ACE I/ D and AT1-receptor A1166C) of the genes of RAS in women with PD-PRM. Paper-13444343.
Fifteen HMSN families with 218 members and documented male-to-male transmission and slow motor nerve conduction velocities were informative for linkage to Duffy blood group (Fy), antithrombin III cDNA probe (AT3) and renin ( REN). Paper-5729986.
The pepsin-activated renin of normal plasma eluted from Sephadex G-100 in a peak of apparent molecular weight (MW) 58,000 and from Sephacryl S-200 with apparent MW 53,000, like big renin in plasma of patients with diabetic nephropathy. Paper-3670407.
In addition to tubular epithelial cells that were positive for AT(1A)R, AT(2)R, REN, and AGTN, interstitial fibroblast-like cells expressed AT(1A)R, REN, AGTN, and ACE in the fibrosing kidney. Paper-9400636.
The REN- AGT complex may stabilize plasma REN concentration and regulate plasma REN activity independent of renal REN secretion and angiotensin II-mediated feedback. Paper-2149890.
No statistically significant differences between groups were found in the allele frequency and genotype distribution for A20C variant of AGT gene, MboI of renin, Gly460Trp of aldosterone and Lys173Arg of adducin (p > 0.05). Paper-13667570.
We therefore investigated whether pharmacologic blockade of ERK and p38 could prevent renal damage in high- renin homozygous transgenic rats ( Ren2), with the effects of an AT(1) receptor antagonist (AT(1)-RA) as a reference. Paper-10052349.
Human decidual tissue, the specialized endometrium of the luteal phase of the menstrual cycle and pregnancy, synthesizes and releases prolactin, relaxin, renin, and at least three insulinlike growth factor (IGF)-binding proteins. Paper-12805828.
Because the renin-angiotensin system is species specific, we bred KAP2- hREN mice with the mice expressing human angiotensinogen under the same promoter ( KAP- hAGT) to produce offspring that expressed both transgenes. Paper-10221291.
These data suggest that there is a major contribution of glial- AGT to the hypertensive state in mice carrying systemically expressed hREN and hAGT genes and confirm the importance of a glial source of ANG II substrate in the brain. Paper-11472865.
The findings show significant ethnic RFLP differences at the gene loci for both renin and ANP and provide evidence for a possible link between variations within or close to the renin gene and elevated blood pressure in Afro-Caribbeans. Paper-48756.
Ten polymorphisms in seven genes- AGT/Thr174Met and AGT/Met235Thr; REN/I8-83G-->A; ACE/insertion(I)-deletion(D); CMA/-1930A-->G; AGTR1/-731T-->G, AGTR1/-521C-->T, and AGTR1/1166A-->C; AGTR2/3123C-->A; and CYP11B2/-344T-->C were examined. Paper-11076271.
1. Active and inactive renin were assayed in plasma of the renal veins and the inferior vena cava below the kidney in eight patients with hypertension and unilateral renal abnormalities, 20 min after the patients had resumed the upright position. Paper-3396930.
Since a weak positive correlation was observed between [EPO]s and [ REN] and a lack of correlation between [EPO]s and [ ALDO], it would seem that there is no direct link between [ REN] and [ ALDO] and erythropoietin synthesis in healthy subjects. Paper-669614.
The most significant interactions for PAI-1 levels were with REN T9435C and the TPA I/ D polymorphisms (p = 0.001) in females, and the association of REN G6567T with the TPA I/ D polymorphisms (p = 0.032) in males. Paper-15671760.
The human renin gene contains a direct repeat (DR) motif AGGGGTCAC-AGGGCCA in the proximal region (-259/-245 bp), which contains similar sequence for nuclear receptor superfamily binding core motif, AGGTCA, and is the most similar to COUP-TFII consensus. Paper-12583107.
Based on these data, particularly those indicating both agents are released by volume expansion, our current view is that low renin hypertension is in part generated by the sodium pump inhibitor and is in part moderated by atrial natriuretic peptide. Paper-5621613.
These variants were studied in autopsy-confirmed AD cases and matched controls from the U.K. While no association was detected with the renin polymorphism, a weak deleterious effect was observed in cases homozygous for the angiotensinogen Thr allele. Paper-10727763.
Here, we tested the hypothesis that glial-derived AGT plays an important role in blood pressure regulation in hypertensive mice carrying human renin ( hREN) and human AGT transgenes under the control of their own endogenous promoters. Paper-11472865.
METHODS: Three haplotype-tagging SNPs (htSNPs) covering REN (rs5705, rs1464818, and rs3795575) and another three covering AGT (rs2148582, rs2478545 and rs943580) were genotyped in 99 mother-father-child triads of preeclampsia pregnancies. Paper-15293697.
We suggest that the atrial natriuretic peptide compensates for increased volume due to reduced renal function and/or increased salt intake and that in low renin hypertension the compensation is not sufficient to return volume and pressure to normal. Paper-5621613.
The recombinant human (rh) RnBP existed as a dimer and its GlcNAc 2-epimerase activity was strongly inhibited by the purified renin concomitant with the formation of RnBP- renin heterodimer, so-called high molecular weight (HMW) renin. Paper-8643659.
The effect of PPARgamma was mapped to two sequences in the renin promoter: a direct repeat hormone response element (HRE), which is related to the classical PPAR response element (PPRE) and a nonconsensus palindromic element with a 3-bp spacer (Pal3). Paper-12917159.
Moreover, direct investigations of pre-treatment renin status in hypertensive blacks in relation to blood pressure response have demonstrated that the pre-treatment PRA is not a good index of subsequent blood pressure response to pharmacological treatment. Paper-8721527.
BACKGROUND: Because no systematic study on the comparison of the stability of plasma renin activity (PRA) and renin concentration ( REN) under different preanalytical conditions has been reported, we examined the impact of several sampling and storage conditions. Paper-13648307.
BACKGROUND: Because no systematic study on the comparison of the stability of plasma renin activity (PRA) and renin concentration ( REN) under different preanalytical conditions has been reported, we examined the impact of several sampling and storage conditions. Paper-14111310.
Other markers examined were MS1, oncogene L-myc (MYCL), beta-subunit of nerve growth factor (NGFB), oncogene N-ras ( NRAS), glucocerebrosidase (GBA), apolipoprotein AII (APOA2), antithrombin III (AT3), renin ( REN), and MS32. Paper-6445010.
Phenotypically, these truncations cause a severe dysregulation of human renin expression, but remarkably, a preservation of the normal tissue-specific expression of the human ethanolamine kinase 2 ( ETNK2) gene which lies immediately downstream of renin. Paper-12927863.
To assess a combined effect of maternal AGT and fetal REN haplotypes, the preeclamptic triads were first stratified by presence/absence of maternal AGT haplotype C-T-A and tested for an effect of fetal REN across these strata. Paper-15293697.
The effect of a synthetic atrial natriuretic peptide (h-ANP, 25 amino acids, Wy-47.663) on blood pressure, renal electrolyte excretion, plasma catecholamines, and plasma renin activity was studied in nine patients with cirrhosis of the liver and ascites. Paper-5790873.
However, few studies have examined the localization of RAS components, such as angiotensin II receptors, renin ( REN), angiotensinogen ( AGTN), and angiotensin-converting enzyme (ACE), in the fibrosing kidney. Paper-9400636.
In an observational study, we examined simultaneously sleep EEG and nocturnal levels of renin, growth hormone ( GH), and cortisol (between 2300 and 0700) in 47 healthy volunteers comprising 24 women (41.67 +/- 2.93 yr of age) and 23 men (37.26 +/- 2.85 yr of age). Paper-13685796.
Concentrations of renin and angiotensin-converting enzyme (ACE) were assayed in BM aspirates and in simultaneously drawn peripheral blood samples of 16 pre-chemotherapy leukemic and 10 post-treatment megaloblastic anemia patients with normal blood counts, as controls. Paper-9609414.
To investigate the role of brain angiotensin II (ANG II) in the pathogenesis of injury following ischemic stroke, mice overexpressing renin and angiotensinogen (R+A+) and their wild-type control animals (R-A-) were used for experimental ischemia studies. Paper-14098860.
Glomerulosclerosis, tubulointerstitial damage and renal osteopontin mRNA expression were reduced in Ren2-AT1 ( P < 0.05, respectively) but remained unchanged or increased further in Ren2- ETA and Ren2- ETA/ B compared with Ren2. Paper-10197159.
Human PC5 was colocalized with renin by immunohistochemistry in the zona glomerulosa of the adrenal gland, suggesting that it could participate in the activation of a local renin-angiotensin system in the human adrenal cortex. Paper-746328.
Significant linkage was established between diastolic blood pressure and a microsatellite marker of the renin gene ( REN) on rat chromosome 13, and between pulse pressure and the carboxypeptidase B gene ( CPB) on chromosome 2. Paper-7853738.
RESULTS: SNPs in renin (rs2368564) and endothelin-1 (rs5370) were associated with reduced risk of edema (P=0.003 and P=0.028, respectively) and an SNP in beta1 adrenergic receptor (rs1801253) was associated with increased susceptibility to edema (P=0.034). Paper-12948144.
We studied 2 transgenic rat (TGR) strains for human (h) AGT; one strain has hAGT values approximately 7-fold higher than the other (68+/-18 versus 10+/-4 microg angiotensin I/mL). hREN (30 000 pg) was bolus-infused into both lines and into nontransgenic controls. Paper-2149890.
We studied 11 individuals with renal tubular dysgenesis, belonging to nine families, and found that they had homozygous or compound heterozygous mutations in the genes encoding renin, angiotensinogen, angiotensin converting enzyme or angiotensin II receptor type 1. Paper-11094589.
The renin secretion index proved to have a higher sensitivity (92%) and predictive value (92%) for a successful outcome of both surgery and PTA than the PRA ratio (69% and 89%, respectively), while the specificity was the same with both parameters (42% and 43%, respectively). Paper-5148963.
In order to study the role of the renin-angiotensin system in patients with diabetic nephropathy, renin release and the juxtaglomerular apparatus were studied in 17 diabetic patients with proteinuria and in 23 without proteinuria; 8 normal subjects were used for conctrls. Paper-3059539.
OBJECTIVE: The association of renin C-4063T and angiotensinogen ( AGT) T174M, AGT M235T and AGT A-6G polymorphisms with ischemic stroke of atherosclerotic etiology was investigated in 329 Tunisian patients with stroke and 444 controls. Paper-13808942.
PAI-1 is upregulated by the renin-angiotensin system (RAS), specifically by angiotensin II, the product of angiotensin converting enzyme (ACE) cleavage of angiotensin I, which is produced by the cleavage of angiotensinogen ( AGT) by renin ( REN). Paper-15671760.
Five genetic variants of the RAS, i.e., renin ( REN) C-5312T, ACE insertion/deletion, angiotensinogen M235T, angiotensin II type 1 receptor A1166C, and angiotensin II type 2 receptor C3123A were assayed by PCR and restriction fragment-length polymorphism. Paper-13901862.
CONCLUSIONS: Sympathetic nerve excitability in group A was greatly increased; hypertensive LVH was closely associated with Ald and Ins level, but not with AT-II and Ren. Group A is characterized by a significantly greater frequency of premature ventricular contractions and ischaemia. Paper-10256544.
Forskolin, which augments REN mRNA stability in Calu-6 cells, increased binding of several proteins, including HuR and CP1, to the REN 3'-UTR, whereas 4-bromocrotonic acid, a specific thiolase inhibitor, decreased binding and elevated renin protein levels. Paper-10165380.
The present study was performed to characterise the changes in plasma and kidney tissue Ang II levels and in renal haemodynamic function in Cyp1a1- Ren2 rats following induction of either slowly developing or malignant hypertension in these transgenic rats. Paper-14713377.
DESIGN: Ren2 animals were treated between 10 and 30 weeks of age with the selective ETA receptor antagonist darusentan (Ren2-ETA) and the ETA/ B receptor antagonist Lu420627 ( Ren2- ETA/ B), and compared with transgene negative Sprague-Dawley (SD) controls. Paper-10197159.
Since the elevated systolic blood pressure in Ren2 was not affected in either Ren2- ETA or Ren2- ETA/ ETB, an additional Ren-2 group was treated with a non-antihypertensive dose of the angiotensin II type 1 receptor blocker eprosartan (Ren2-AT1). Paper-10197159.
Since the renin gene is a member of a conserved synteny group that in humans spans chromosome 1q21.3-32.3 and includes the gene for antithrombin III ( AT3), we used linkage studies to examine the relationship between alleles of AT3 and hypertension in a family having 10 affected members. Paper-36354.
As renin is the key enzyme of the renin-angiotensin-aldosterone system, the renin gene ( REN) represents a good candidate quantitative trait locus for investigations aimed at uncovering the molecular and genetic influences implicated in the molecular etiology of essential hypertension. Paper-2043795.
We tested the nephroprotective potential of selective endothelin A receptor ( ETA) and non-selective ETA and endothelin B ( ETA/ B) receptor blockade in the TGR(mRen2)27 transgenic rat model with renin-dependent hypertension ( Ren2). Paper-10197159.
The aim of this study was to determine the association of five genetic polymorphisms (A6G and A20C of angiotensinogen ( AGT), MboI of renin, Gly460Trp of aldosterone synthase and Lys173Arg of adducin) of RAAS genes in Malaysian essential hypertensive and type 2 diabetic subjects. Paper-13667570.
CONTENTS: Although information from messenger RNA studies may be reliable for tissues such as kidney and, in mouse, submandibular gland, which have relatively high expression, more sensitive approaches, e.g. polymerase chain reaction technology, are needed for studies of renin gene regulation in other tissues. Paper-7545165.
Plasma prolactin level and plasma renin activity were determined in normal subjects and patients with low and normal renin essential hypertension, renal hypertension, renovascular hypertension, primary aldosteronism, Cushing syndrome, pheochromocytoma and malignant hypertension. Paper-5106476.
The findings suggest that renin production is not increased in diabetic patients with proteinuria plus marked vascular damage, and that the renin-angiotensin system in patients with diabetic nephropathy apparently does not play an important role in the exacerbation of hypertension or the degree of vascular damage. Paper-3059539.
Plasma prorenin was therefore separated from active renin and from the protease inhibitors alpha 2-macroglobulin, C1-inactivator, alpha 1-antitrypsin, inter-alpha-trypsin inhibitor, and antithrombin III by gel filtration on Sephadex G-100 and affinity chromatography on Blue Sepharose CL-6B at neutral pH. Paper-4205175.
From these results, it was shown that significant differences of plasma prolactin levels exist between normal renin essential hypertensives, and low renin essential hypertensives or normal subjects, and that these differences may partly depend on renin status which might be related to the central dopaminergic activity. Paper-5106476.
METHODS AND RESULTS: We performed an experiment with dense tagging single-nucleotide polymorphism coverage of 4 genes encoding proteins that control the overall activity of the cascade, namely renin, angiotensinogen, angiotensin-converting enzyme, and angiotensin-converting enzyme 2, in 2 Irish populations. Paper-14250867.
Objectives: This research analysed renin ( REN), angiotensin II (ANG), aldosterone (ALD) and vasopressin (AVP) in horses covering different distances, assesses differences between successful and eliminated horses and evaluates correlations between hydration status, renal function, electrolytes, REN, ANG, ALD and AVP. Paper-15922690.
INTRODUCTION: Transgenic rats with inducible angiotensin II (Ang II)-dependent hypertension (strain name: TGR[Cyp1a1- Ren2]) were generated by inserting the mouse Ren2 renin gene, fused to the cytochrome P450 1a1 ( Cyp1a1) promoter, into the genome of the rat. Paper-14713377.
This study aimed to assess the role of cAMP target sequences enhancer cAMP response element (enhCRE) and cAMP and overlapping negative response element (CNRE) in the control of human renin gene ( REN) in vivo. enhCRE and CNRE were silenced by mutations in a 12.2-kb human renin promoter fused to LacZ reporter gene. Paper-15797573.
METHODS: Systolic tail blood pressure, mean arterial blood pressure, pulse rate, heart mass, body mass and relative heart mass were determined for each rat in the age range 17-19 weeks, and DNA polymorphisms were examined for the guanylyl cyclase A (GCA), angiotensin converting enzyme (ACE) and renin ( REN) genes. Paper-305305.
5. Specific biochemical test that suggest the existence of certain disorders, such as hypercalcemia in hyperparathyroidism, hyperglycemia in Cushing's syndrome and pheochromocytoma, and unprovoked hypokalemia with renin-producing tumors, primary hyperaldosteronism, or renin-mediated renovascular hypertension. Paper-770936.
The present study examined the association of particular human renin gene ( REN) and antithrombin III gene (AT3) polymorphisms with essential hypertension by comparing the frequency of specific alleles for each of these genes in 50 hypertensive offspring of hypertensive parents and 91 normotensive offspring of normotensive parents. Paper-51905.
Therefore, we directly evaluated whether this form of renin has physiological implications for BP regulation by characterizing transgenic mice expressing human icREN driven by the glial fibrillary acidic protein ( GFAP) promoter and comparing it with similar mice expressing the secreted form of renin. Paper-10828982.
The influence on homologous and heterologous promoter activity of DNA extending 2.4 kb upstream of the human renin gene ( REN) was examined by transient expression assay in JEG-3 cells, using the gene for chloramphenicol acetyl transferase (CAT) as reporter, and cotransfection with pCH110 to control for transfection efficiency. Paper-7014094.
METHODS: In a population-based case-control study set in King County, Washington, 211 SCA cases (80% male; mean age 59 years,) and 730 age- and gender-matched controls of European descent were genotyped for 47 single nucleotide polymorphisms ( SNPs) in eight genes (ACE, AGT, REN, AGTR1, AGTR2, ACE2, KNG1, BDKRB2). Paper-13961546.
Thus, although cure after both surgery and PTA is more likely in the presence of lateralized renin secretion and contralateral suppression, the method does not allow to exclude patients with severe renal artery stenosis, hypertension and negative renal venous renin tests from these interventions.(ABSTRACT TRUNCATED AT 250 WORDS) Paper-5148963.
These studies suggest that sequences flanking the structural gene, missing from previous hREN transgenic lines, suppress renin gene expression at inappropriate extrarenal sites where cellular proteases, to which prorenin is not normally exposed, could convert prorenin to renin, resulting in abnormal secretion of renin into the plasma. Paper-1702327.
They all formed embryoid bodies in suspension cultures, and after seeding in culture plates they showed pluripotency in vitro by forming cell lineages derived from all three germ layers as indicated by expression of the ectodermal marker nestin, the mesodermal marker renin, and the endodermal markers alpha-fetoprotein and GATA6. Paper-11382185.
Therefore, we generated and characterized transgenic mice overexpressing human renin ( hREN) under the control of the glial fibrillary acidic protein ( GFAP) promoter ( GFAP- hREN) and synapsin-I promoter (SYN- hREN) and bred them with mice expressing human angiotensinogen (hAGT) under the control of the same promoters (GFAP-hAGT and SYN-hAGT). Paper-9169502.
Those that had a significant correlation with the mean postoperative diuresis were: renin at 6 h (r2 = 0.29, P = 0.03), 8h (r2 = 0.26, P = 0.04) and 12h (r2 = 0.31, P = 0.03), aldosterone at 6h (r2 = 0.54, P = 0.001), 8h (r2 = 0.40, P = 0.01) and 12h (r2 = 0.32, P = 0.03), ADH at 24h (r2 = 0.38, P = 0.01) and ANF at 6h (r2 = 0.26, P = 0.045). Paper-10881949.
In conclusion, HADHB, HuR, and CP1 are novel REN mRNA- binding proteins that target a cis-element in the 3'-UTR of REN mRNA and regulate renin production. cAMP- mediated increased REN mRNA stability may involve stimulation of HuR and CP1, whereas REN mRNA decay may involve thiolase-dependent pathways. Paper-10165380.
The influence of neutral endopeptidase ( NEP) inhibition with (S)-thiorphan on the hormonal, renal, and blood-pressure-lowering effects of an infusion of atrial ( ANP), brain (BNP), and C-type natriuretic peptide ( CNP) was evaluated in hypertensive transgenic rats (TGR) harboring an additional mouse renin gene (TGR(m(Ren2)27)). Paper-920644.
CONCLUSIONS: Activation of AT1-receptors by Ang II generated as a consequence of induction of the Cyp1a1- Ren2 transgene mediates the increased arterial pressure and the associated reduction of renal haemodynamics and enhancement of intrarenal Ang II levels in hypertensive Cyp1a1- Ren2 transgenic rats. Paper-14713377.
These synonyms are used for gene REN (renin): Renin, HNFJ2, FLJ10761, Angiotensinogenase.
These accession numbers are used for gene REN: X00063 (NCBI_GENBANK__AC), Q6T5C2 (UNIPROT__AC), Q6FI38 (UNIPROT__AC), BP321283 (NCBI_GENBANK__AC).
REN is a homologue of Ren1 (renin 1 structural) from Mus musculus.
REN is a homologue of REN (renin) from Pan troglodytes.
REN is a homologue of REN (renin) from Canis lupus familiaris.
REN is a homologue of REN (renin) from Bos taurus.
REN is a homologue of Ren (renin) from Rattus norvegicus.
REN is a homologue of ren (renin) from Danio rerio.
REN is a homologue of CG10104 (CG10104 gene product from transcript CG10104-RA) from Drosophila melanogaster.
Important links !
iHOP - Information Hyperlinked over Proteins .
Concept & Implementation by Robert Hoffmann.