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Tra2 beta directly and ASF/ SF2 indirectly associated with the ESE of wild tau exon 10. Paper-10487993.
Like most splicing factors, htra2-beta and clk2 pre-mRNAs are regulated by alternative splicing. Paper-10846546.
However, correct splicing can be restored by over-expression of the SR-like splicing factor Htra2-beta 1. Paper-10136295.
Tra2 beta, SF2/ ASF and SRp30c modulate the function of an exonic splicing enhancer in exon 10 of tau pre-mRNA. Paper-10487993.
Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta. Paper-9720125.
Overexpression of RNPS1 in HeLa cells induced exon skipping in a model beta-globin pre-mRNA and a human tra-2 beta pre-mRNA. Paper-10206578.
The resulting HTRA2- BETA3 protein lacks the first RS domain of HTRA2-BETA1, is expressed in several tissues and has no influence on tra2-beta splice site selection. Paper-10487858.
Importantly, this up-regulation of SMN could be most likely attributed to increased levels of Htra2-beta 1 which facilitates the correct splicing of SMN2 RNA as well as to an SMN gene transcription activation. Paper-10136295.
Here, we investigated whether human postmortem brain tissue of AD patients reveal differences in alternative splicing patterns of the tau, htra2-beta, presenilin 2 and clk2 genes when compared with age-matched controls. Paper-10846546.
We have previously shown that transient expression of an SR-like splicing factor, hTra2 beta 1, stimulates inclusion of exon 7 in SMN2-derived mini-gene transcripts through an interaction with the AG-rich exonic splice enhancer within exon 7. Paper-9196793.
Four factors were identified: p54 (also called SRp54; a member of the SR protein family), human transformer 2 beta ( hTra2 beta; an exonic splicing enhancer-binding protein), hLucA (a potential component of U1 snRNP), and pinin (also called DRS and MemA; a protein localized in nuclear speckles). Paper-10206578.
These synonyms are used for gene TRA2B (transformer 2 beta homolog (Drosophila)): Transformer-2 protein homolog beta, Transformer-2 protein homolog B, TRAN2B, TRA2-BETA, SRFS10, Splicing factor, arginine/serine-rich 10, SFRS10, HTRA2-beta, Htra2-beta, DKFZp686F18120.
These accession numbers are used for gene TRA2B: Q8N1H4 (UNIPROT__AC), B4DVK2 (UNIPROT__AC), AAD19278 (NCBI_GENBANK__AC), AAB69763 (NCBI_GENBANK__AC).
TRA2B is a homologue of TRA2B (transformer 2 beta homolog (Drosophila)) from Bos taurus.
TRA2B is a homologue of TRA2B (transformer 2 beta homolog (Drosophila)) from Pan troglodytes.
TRA2B is a homologue of TRA2B (transformer 2 beta homolog (Drosophila)) from Gallus gallus.
TRA2B is a homologue of TRA2B (transformer 2 beta homolog (Drosophila)) from Canis lupus familiaris.
TRA2B is a homologue of Tra2b (transformer 2 beta homolog (Drosophila)) from Mus musculus.
TRA2B is a homologue of tra2b (transformer 2 beta homolog (Drosophila)) from Danio rerio.
TRA2B is a homologue of Sfrs10 (splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)) from Rattus norvegicus.
TRA2B is a homologue of rsp-8 (SR Protein (splicing factor)) from Caenorhabditis elegans.
Important links !
iHOP - Information Hyperlinked over Proteins .
Concept & Implementation by Robert Hoffmann.