The most recent information on SLC6A4 is here. Click here for the function of SLC6A4. Edit this page in Wiki Genes - SLC6A4 or see Wiki Gene. ITGB3 shows genetic and expression interaction with SLC6A4. Paper-12139528. There were also non- SERT neurons expressing ERbeta mRNA. Paper-9019768. Both compounds showed potent inhibitory activities against AChE and SERT. Paper-9239695. Together, these results indicate a distinct role of p38 MAPK in SERT regulation. Paper-10759515. We thus show for the first time that the cytokine TNF-alpha modulates 5-HTT function. Paper-1643999. The modulation correlates with a shift in the affinity of SERT for syntaxin 1A binding. Paper-12994707. In contrast, the monomers of CFP- hSERT and YFP- hSERT were essentially undetectable. Paper-8952395. SB203580 selectively blocked the TNF-alpha- induced change in SERT K(m). Paper-12232665. We observed neither main effects nor interactions with CYP2A6, DAT, and SLC6A4 genes. Paper-12686654. CONCLUSIONS: These results support an involvement of 5-HTTLPR in the etiology of MDD. Paper-10787992. The regulation by CaM kinase II is eliminated by a mutation in the N-terminal domain of SERT. Paper-12994707. LEPR, ADBR3, IRS-1 and 5-HTT genes polymorphisms do not associate with obesity. Paper-13159144. There was no significant difference in mitochondrial RNA expression of MKK 7, TrKB, and 5HTT. Paper-12209698. At this same time, EB treatment increased Pet-1 and 5-HTT mRNA levels within the DRN and MRN. Paper-13655734. This may indicate in vivo competition between ADAM and 5-HT for binding to the SERT. Paper-10205893. Whole-cell treatments with okadaic acid or calyculin A diminished SERT/ PP2Ac associations. Paper-8747618. In contrast, TNF-alpha stimulation decreased 5-HT K(m) and increased SERT V(max). Paper-12232665. Previously, we showed that syntaxin 1A regulates the transport stoichiometry of SERT. Paper-12994707. The increase in SERT/ NSE was highly significant (P<0.01) in DS frontal cortex compared to controls. Paper-8513006. Interestingly, another substrate, N-methyl-4-phenylpyridinium ( MPP+), was transported only by hSERT. Paper-9746312. Effects of 5-HTT and COMT genotypes did not affect brain processing of pleasant stimuli. Paper-13132305. Our data do not support the implication of the 5-HTT gene in the psychiatric comorbidities of NF1. Paper-10727762. We demonstrate that one of the mitogen-activated protein kinases (MAPKs), p38 MAPK, regulates SERT. Paper-10759515. GST-pulldown assays confirmed the physical interaction between SCAMP2 and the N-terminal domain of SERT. Paper-12242696. For protective allele associations, the ORs are between 0.842 and 0.886, for DAO, IL1B, and SLC6A4. Paper-12982428. In the second part, the selectivity of the compounds for DAT binding vs SERT binding is studied. Paper-9422829. We also examine whether ITGB3 might interact with SLC6A4 to contribute to autism susceptibility. Paper-12139528. In contrast, SERT immunoreactivity is clearly segregated from transferrin receptor-containing endosomes. Paper-12242696. Polymorphisms in SLC6A4, PAH, GABRB3, and MAOB and modification of psychotic disorder features. Paper-13691070. [(123)I] ADAM is a novel radiotracer that selectively binds the 5-HTT of the central nervous system. Paper-13072689. Social adversity, the serotonin transporter ( 5-HTTLPR) polymorphism and major depressive disorder. Paper-11331369. CONCLUSIONS: 5-HTT gene polymorphism appears to determine the severity of PH in hypoxemic patients with COPD. Paper-10031703. In vivo expression of 5-HTT by PA- SMC may play a key role in serotonin-mediated pulmonary vascular remodeling. Paper-1751542. Recently, radioligands targeting the brain serotonin transport protein ( SERT) have been developed. Paper-13314755. The 5HT uptake rate of placental SERT is important for both the mother and the developing embryo. Paper-13212527. We have also examined two other 5HTT polymorphisms (the VNTR in intron 2 and the 3' UTR SNP). Paper-9315965. Functional SLITRK1 var321, varCDfs and SLC6A4 G56A variants and susceptibility to obsessive-compulsive disorder. Paper-12197069. Alterations in expression of p11 and SERT in mucosal biopsy specimens of patients with irritable bowel syndrome. Paper-12435341. A remarkable difference was noted when SERT was normalized vs. neuron specific enolase ( NSE), a neuronal marker. Paper-8513006. Family-based and case-control study of DRD2, DAT, 5HTT, COMT genes polymorphisms in alcohol dependence. Paper-12305556. Familial migraine with aura: association study with 5-HT1B/ 1D, 5-HT2C, and hSERT polymorphisms. Paper-10338641. Characterization of a functional polymorphism in the 3' UTR of SLC6A4 and its association with drinking intensity. Paper-13593993. Only three of the candidates-DRD5, 5HTT, and CALCYON-coincided with sites of positive linkage identified by our screen. Paper-9160218. (b) That reduction of the density of SERT may be a homeostatic reaction in the brain following epileptic seizures. Paper-12119599. CONCLUSIONS: Schizophrenia is generally not associated with alterations of DAT in the striatum or SERT in the brainstem. Paper-2143421. Serotonin transporter ( 5-HTT) promoter genotype may influence the prolactin response to clomipramine. Paper-8353625. We have constructed a 1 Mb YAC and PAC contig which harbours both the SLC6A4 and the carboxypeptidase D ( CPD) genes. Paper-2165529. Two genes that have been implicated as conferring susceptibility to ASD are PTEN and Serotonin transporter ( SLC6A4). Paper-13611776. The binding of [(3)H]paroxetine to SERT and [(3)H]lazabemide to MAO-B were higher in the raphe nuclei than in the LC. Paper-9931880. No evidences for biased transmissions of both HTR2A -1438 A > G and SLC6A4 polymorphisms to ADHD youths were observed. Paper-12385119. These results suggest that functional variants of 5-HTT and COMT impact brain functions involved in stress and anxiety. Paper-11389104. Striatal D2 and 5-HT1A receptors were studied in schizophrenia and 5-HT transporters ( 5-HTT) in depression and bulimia. Paper-9276589. All subjects were then genotyped for selected polymorphisms at the SLC6A4, HTR7, HTR2A, ITGB3, and TPH1 loci. Paper-12660183. METHODS: Messenger RNA (mRNA) expression of SLC6A4 and p11 was measured in sigmoid and rectal mucosal biopsy specimens. Paper-12435341. In addition, BDNF Val66Met and 5-HTTLPR polymorphisms seemed to moderate the effect of CSA on adult depressive symptoms. Paper-13916224. Neither polymorphisms were associated with symptoms of fatigue ( IL-6: F=1.2, d.f.=430, P=0.2; 5-HTT: F=0.5, d.f.=430, P=0.5). Paper-13077074. Allelic frequencies of genomic variations for 5HTT, NAT1, NAT2, PON1, PON2, and SOD2 were determined. Paper-12843455. Furthermore a progressive truncation of the C-terminus of SERT was performed to map the vimentin- SERT association domain. Paper-13654445. No gene by environment (GxE) interactions between the 5-HTTLPR genotype, social adversity, and MDD were observed. Paper-11331369. Association study of polymorphisms in LRP1, tau and 5-HTT genes and Alzheimer's disease in a sample of Colombian patients. Paper-12195037. In these nuclei, we demonstrate that the distribution of 5-HTT- labeled fibers follows the distribution of OT-labeled cells. Paper-13190714. Taken together, our results suggest that SCAMP2 plays an important role in the regulation of the subcellular distribution of SERT. Paper-12242696. ERbeta mRNA hybridization signal was expressed in most cells containing SERT mRNA in the dorsal and median raphe and pons. Paper-9019768. Panic disorder is associated with the serotonin transporter gene ( SLC6A4) but not the promoter region (5-HTTLPR). Paper-13529401. OCT3 may be an important transporter mediating serotonergic signaling when 5-HTT expression or function is compromised. Paper-13476234. Mimicking clinical use by treating PBMC with a combination of IFN-alpha and ribavirin increased the 5-HTT mRNA expression level. Paper-10844945. Also, there were significantly fewer SERT mRNA-positive cells in the dorsal raphe of E- and E+P-treated groups ( ANOVA, P<0.001). Paper-1375333. In the present study, using the yeast two-hybrid system, we identified the membrane glycoprotein M6B as a binding partner of SERT. Paper-13526031. Autoradiography of AFM or DASB binding was compared in the brains of mice with genetically normal, diminished, or absent SERT. Paper-10205843. The expression of SERT in induced T-REx-SERT cells was 400,000 copies per cell, but in MEL- SERT it was only 80,000 copies per cell. Paper-9678806. Association of different susceptibilities to morphine with the expression of 5-HTT and 5-HT1AR mRNA in brain regions of SD rats. Paper-13009074. Incubation of thalamocortical cultures with botulinum toxin C1, which specifically cleaves syntaxin 1A, decreased SERT function. Paper-9225740. WFS1 and HTT are related to the unfolded protein response and endoplasmic reticulum stress, and TBC1D1 is a GTPase activator. Paper-13690718. These results implicate distal domains and a single residue in TMD 12 in the formation of high affinity SERT antagonist binding sites. Paper-718961. Significant associations were identified for several candidate genes including DAT1, DRD4, DRD5, 5HTT, HTR1B, and SNAP25. Paper-13783758. The translocation of SERT between these compartments is correlated with changes in the interaction with the LIM domain adaptor protein Hic-5. Paper-12183934. Quantitative structure-activity relationship of phenoxyphenyl-methanamine compounds with 5HT2A, SERT, and hERG activities. Paper-13092630. METHODS: DNA was obtained from 64 patients treated with sertraline plus T3 (SERT-T3, N=35) or plus placebo ( SERT- PLB, N=29), for 8 weeks. Paper-13525145. We performed an extensive analysis of SLC6A4 on DNA of 254 BPI patients and 364 control individuals from a Northern Swedish isolated population. Paper-13537893. FKBP5, SERT and COMT mRNA expressions in the peripheral leukocytes during menstruation cycle in healthy reproductive females. Paper-12768538. OPRM1 (AA>AG or GG) was associated with smoking reward, but SLC6A4 variable number tandem repeat was unrelated to any of these measures. Paper-12965354. Using a yeast one-hybrid screen, we found the transcription factor Y box binding protein 1 ( YB-1) interacts with the 5-HTT VNTR. Paper-10442691. The SERT inhibitors desipramine and fluoxetine also inhibited (3)H- MPP(+) specific uptake (with IC(50)s of 189 and 0.92 microM, respectively). Paper-10019407. The present results suggest that both AFM and DASB are highly selective SERT ligands potentially suitable for use in human PET studies of SERT. Paper-10205843. Alterations in PD, c-fos, and SERT expression could contribute to the depression-like syndrome associated with psychostimulant withdrawal. Paper-13593738. Synthesis and characterization of an improved SERT imaging agent, ADAM (2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine)(7) was achieved. Paper-8431167. This gene is adjacent to the NF1 gene, raising the question of the implication of the 5-HTT gene in the psychiatric comorbidity during NF1. Paper-10727762. The endothelial nitric oxide synthase ( eNOS) expressions in tumors were reduced in 5-HTT(-/-) mice compared with 5-HTT(+/+) mice. Paper-13681051. To test if the midline contains an activity that induces SERT, cuts were made that separated serotonergic cell bodies from the midline. Paper-2048050. In addition, immunofluorescence for the serotonin reuptake transporter ( SERT) was observed in the cell body region of undifferentiated B14 cells. Paper-9835395. In the SON, 5-HTT- labeled fibers and OT-labeled cells overlap in the ventromedial subdivision and in the 'capsular' part of the dorsolateral SON. Paper-13190714. The correlation of the SERT promoter polymorphism with age at diagnosis in FPAH suggests a possible relationship between the SERT and BMPR2. Paper-11313406. In neonatal thalomocortical neurons that endogenously express SERT and syntaxin 1A, inhibition of CaM kinase II reveals SERT-mediated currents. Paper-12994707. To date, there is statistically significant evidence for six MDD susceptibility genes ( APOE, DRD4, GNB3, MTHFR, SLC6A3 and SLC6A4). Paper-12935989. Moreover, genetic variation in ITGB3 is associated with expression of both ITGB3 (P=0.012) and SLC6A4 (P=0.008) in unrelated CEPH individuals. Paper-12139528. We also show preliminary evidence that genotypes at the ITGB3 and SLC6A4 loci may interact to affect autism susceptibility (P=0.033). Paper-12139528. The SERT availability was approximated using SPECT and [123I] ADAM while the DAT availability was approximated using SPECT and [99mTc] TRODAT-1. Paper-13627084. Moreover, we also demonstrated SERT expression in glial fibrillary acidic protein-positive cells by immunocytochemical staining in normal human astrocytes. Paper-8810374. No association between FD and the genotype of the insertion/deletion polymorphism in the promoter of SERT (SERT-P) or HTR3A C178T polymorphism was observed. Paper-12836609. In the grasshopper CNS, serotonergic growth cones cross the midline early in development and initiate expression of serotonin uptake activity, or SERT. Paper-2048050. At these positions, many other mouse lines, including DBA/2J, encode, respectively, Glu-39 and Arg-152 (ER haplotype), amino acids found also in hSERT. Paper-13611905. Except a marked decrease in Kv channels, no changes in the lung expression of mediators of pulmonary vascular remodeling were observed in SM22- 5-HTT(+) mice. Paper-12018776. The present data show that the SNARE protein syntaxin 1A binds the N-terminal tail of SERT, and this interaction regulates two SERT-conducting states. Paper-10167269. Further studies are required to determine whether the increased expression of Pet-1 and 5-HTT mRNA plays a causal role in the anorexigenic effect of estradiol. Paper-13655734. Immunocytochemical analyses were performed using antisera to 5-HT, to the serotonin transporter ( SERT), and to the vesicular monoamine transporter ( VMAT2). Paper-12266774. Agents capable of selectively inhibiting 5-HTT- mediated PA- SMC proliferation deserve to be investigated as potential treatments for pulmonary hypertension. Paper-12159726. During the HTT, thermal and thirst sensations, RPE, rectal temperature (Tre), heart rate (HR), and mean weighted skin temperature (Tsk) were measured. Paper-12345887. Since both 5-HT and TNF-alpha are elevated at sites of inflammation, TNF-alpha may act to renormalize 5-HT levels by way of its effect on the 5-HTT. Paper-1643999. CONCLUSIONS: An association between polymorphisms of ACE, AGT, ATR1 and SERT gene, and predisposition to VVS was not proven by the present study (Tab. 2, Ref. 22). Paper-13747103. BACKGROUND: The propensity for severe drinking is hypothesized to be regulated by differential expression of serotonin transporter gene ( SLC6A4) in the human brain. Paper-13593993. In the present report, the interaction of syntaxin 1A with endogenous serotonin transporters ( SERT) expressed in developing thalamocortical neurons is examined. Paper-9225740. DRD2A, DRD2B, GABB2, EAAT2, and 5HTT genotypes did not divide alcoholic cases and controls on N-methyl-d-aspartate ( NMDA) receptor parameters. Paper-10619816. In the E- and E+P-treated groups compared to the control group, there was a 32% and 33% decrease in SERT mRNA signal represented by pixel number ( ANOVA, P<0.05). Paper-1375333. All patients were genotyped for functional variations in the 5-HT(1A) receptor ( HTR1A), 5-HT transporter ( SLC6A4, 5-HTT), and tryptophan hydoxylase-2 ( TPH2). Paper-13210845. These included neuronal nitric oxide synthase (nNOS), a PSD-95/Disc large/ ZO-1 (PDZ) domain-containing protein recruited by the atypical PDZ binding motif of SERT. Paper-13228555. People who were homozygous for the short gene ( SS) displayed decreased SERT IR, whereas those who were homozygous for the long gene (LL) demonstrated increased SERT IR. Paper-12207391. Further investigation will be required to establish whether SERT binding is more or less decreased in those patients with PD who also have major depressive disorder. Paper-13186884. 5-HTT and TPH2 variations did not contribute significantly to the prediction of interferon- induced depression by HTR1A (sensitivity, 35.9%; specificity, 84.0%). Paper-13210845. Pharmacological and clinical studies have shown that the 5-HT transporter ( 5-HTT) and the 5-HT1A receptor appear to be candidate loci for the aetiology of alcohol dependence. Paper-1799881. A fourth possible explanation might be SLC6A4 x BDNF interactions, which prompted us to investigate combined genotypes of BDNF V66M with the three SLC6A4 loci. Paper-12609707. Biotinylation studies showed reduced SERT proteins in the plasma membrane of synaptosomes after p38 MAPK inhibition and PKC activation. Paper-10759515. In the present study we investigated the influence of interleukin-4 ( IL-4), which acts as an anti-inflammatory cytokine in the central nervous system, on the 5-HTT. Paper-8683601. No differences were found between the allele distribution of polymorphisms at DRD2, DRD4, DAT, and SERT in probands and parental nontransmitted chromosomes. Paper-8332953. Of these, 41 studies investigated 45 different 5-HT receptor variants and 45 studies investigated at least one of two commonly studied 5-HTT polymorphisms in MDD. Paper-9921213. In the final model, the only significant variables selected for smoking were OGG1, SLC6A4, EPHX1, ESR1, and CYP17A1, and for drinking, ALDH2 and NUDT1. Paper-11282139. Association study of the INPP1, 5HTT, BDNF, AP-2beta and GSK-3beta GENE variants and restrospectively scored response to lithium prophylaxis in bipolar disorder. Paper-12062094. The aim of this study was to investigate potential alterations of striatal dopamine transporters ( DAT) and brainstem serotonin transporters ( SERT) density in schizophrenia. Paper-2143421. We performed 5-HTT and 5-HT1A binding, 5-HTT mRNA in situ and tryptophan hydroxylase ( TPH) immunoautoradiography on depressed suicides and controls brainstem sections. Paper-12219035. For this purpose, we generated fusion proteins of hSERT and spectral variants of the green fluorescent protein (cyan and yellow fluorescent proteins, CFP and YFP, respectively). Paper-8952395. We also documented seasonal variations in brain serotonergic function by our finding of reduced brain 5- HTT availability in winter (compared to summer) in healthy controls. Paper-9276589. Weak, though significant, association coefficients obtained with HTT and LEPR loci indicate that the genotype numbers at these loci may depend on BMI status to some extent. Paper-13159144. After immunization with MOGp 35-55, or with rat MBP, the disease courses of the 5-HTT knockout mice were attenuated as compared to wildtype control mice. Paper-11101583. In addition to the previously reported contribution of SLC6A4, we found significant associations of ITGB3 haplotypes with serotonin level distribution (P = 0.0163). Paper-13150896. A weaker, but nevertheless replicated, body of evidence also supports associations with SNAP-25 (synaptosomal-associated protein, 25 kDa) and SLC6A4 ( serotonin transporter). Paper-11533164. The co-expression of SERT with M6B results in a significant decrease in SERT-mediated serotonin uptake caused by a down-regulation of SERT surface expression. Paper-13526031. Five candidate genes, the receptors DRD2, DRD3, HTR2A and GABA(A)gamma2, and the serotonin transporter ( 5-HTT) were analyzed for association with heroin abuse. Paper-9200783. The present study strongly suggests that the activation of 5HT2BR and inhibition of 5HTT played a significant role in the pathogenesis of 5HT-induced valvulopathy in SD rats. Paper-12881564. Markers within, or close to, each of the serotonergic genes 5HTT, HTR2A, HTR2C, MAOA ( monoamine oxidase type A) and tryptophan hydroxylase ( TPH) were genotyped. Paper-10624365. No association was found between 5-HT neuron count or density, 5-HT(1A) receptor binding density, or 5-HTT receptor binding density and other risk factors. Paper-12299726. The nonsynonymous variants rs1383180 in EVC gene, rs6811863 in TBC1D1 gene, rs362272 in HTT gene, and rs734312 in WFS1 gene were associated to the male completed suicide. Paper-13690718. As JAR cells, as well as the placenta, express the neuronal serotonin transporter ( SERT), a comparison between the uptake of (3)H- MPP(+) and (3)H-serotonin ((3)H-5HT) was made. Paper-10019407. In endogenous and heterologous expression systems, our proteomic and biochemical analysis demonstrated that an intermediate filament, vimentin, binds to the C-terminus of SERT. Paper-13654445. We present novel data on the immunocytochemistry of the vesicular monoamine transporter ( VMAT2) and of the high-affinity serotonin transporter ( SERT) in human fetuses. Paper-9209781. In addition, SERT was found to form a complex with SCAMP2 as demonstrated by co-immunoprecipitation from a heterologous expression system and from rat brain homogenate. Paper-12242696. The S enantiomers displayed higher dopamine transporter ( DAT) affinity and the R enantiomers were found to interact at the serotonin transporter ( SERT) with higher affinity. Paper-9396722. By additional ablation of the dopamine transporter ( DAT), this aberrant 5-HT accumulation was abolished in MAOA/ 5-HTT/ DAT triple knockout mice. Paper-12108118. The research of some candidate genes ( DRD4, DAT, DRD5, DBH, 5HTT, HTR1B and SNAP25) brought consistent results confirming the heredity of ADHD syndromes. Paper-12387159. Conversely, following 5HT stimulation, the association between vimentin- SERT is enhanced which changes the cellular distribution of SERT on an altered vimentin network. Paper-13654445. We conclude that 5-HTT activity plays a key role in the pathogenesis of PA- SMC proliferation in PPH and that a 5HTT polymorphism confers susceptibility to PPH. Paper-9047875. Relative 5-HTT mRNA levels were determined in 53 permanent lymphoblast cell lines by semiquantitative real-time polymerase chain reaction using beta-actin as reference. Paper-10280153. SERT mRNA expression was decreased in the DRN, and PD mRNA expression was increased in the adjacent ventrolateral periaqueductal gray (VLPAG) following D-AMPH withdrawal. Paper-13593738. Our study indicates that these therapeutic drugs regulate 5-HTT expression, which implies that 5-HTT might be a trait marker in IFN-alpha-induced depression after hepatic therapy. Paper-10844945. Other examples of the successful application of AEI analysis for studying functional polymorphism include 5-HTT ( serotonin transporter, SLC6A4) and OPRM1 (mu opioid receptor). Paper-12259552. Accordingly, we first examined the potency of MPEP to bind to or inhibit uptake at the NET as well as the dopamine and serotonin transporters ( DAT and SERT, respectively). Paper-10159657. Across all three regimens, Dex administration evoked upregulation of cerebrocortical 5HT1A and 5HT2 receptors and the presynaptic 5HT transporter, greatest for 5HT1A receptors. Paper-11831201. Associations of SERT with Hic-5 are evident in brain synaptosomes, suggesting the existence of parallel mechanisms operating to regulate SERT at serotonergic synapses. Paper-12183934. There were no differences in 5-HTT genotype or 5-HT2c allele distribution between the ADHD+ subgroups and alcoholics without comorbidity and matched controls, respectively. Paper-10189238. In synaptosomes, PKC activation but not p38 MAPK inhibition resulted in SERT redistribution from cholesterolrich lipid raft fractions to nonlipid raft fractions. Paper-10759515. Brain 5- HTT binding potential (BP) may have an important role during MDE due to major depressive disorder, because the 5-HTT regulates extracellular 5-HT. Paper-10616900. In addition, we studied whether paroxetine was able to block (123)I-FP-CIT binding in SERT-rich brain areas and in lung tissue, as lung tissue contains a considerable amount of SERTs. Paper-13136007. While the TPH protein in the midbrain of Ovx rats was significantly higher than others, the SERT levels were not significantly different among groups in all measured brain areas. Paper-13513771. While DCT is in good overall agreement with GAT and HTT, there is some systematic deviation at different pressure ranges in normal, ocular hypertension, and glaucoma populations. Paper-12515018. The SLC6A3 3' UTR 40-bp variable number of tandem repeats ( VNTR) and the SLC6A4 5' 44-bp insertion/deletion polymorphism were analyzed by polymerase chain reaction. Paper-13122678. Allelic variation of the hSERT, with 9, 10, and 12 copies of a "repetitive element," was studied by polymerase chain reaction amplification of the variable number tandem repeat region. Paper-10338641. Two specific meta-analyses were carried out, pooling studies investigating the 5-HT2A 102 T/C and the 5-HTT promoter loci that included, respectively, a total of 1599 and 2539 subjects. Paper-9932275. Furthermore, we find, using confocal microscopy, that M6B co-localizes with SERT when transiently expressed in HEK-MSR-293 cells and when endogenously expressed in RN46A cells. Paper-13526031. The FKBP5 mRNA expression was significantly lower in the follicular phase than in the other phases but no changes were seen in either SERT or COMT mRNA expressions among the phases. Paper-12768538. No causal role for the G482T and G689T polymorphisms in translation regulation of serotonin transporter ( SLC6A4) or association with attention-deficit-hyperactivity disorder ( ADHD). Paper-13764215. Polymorphisms in genes encoding the serotonin receptor type three A subunit ( HTR3A), the serotonin transporter ( SERT) and the G-protein beta3 subunit ( GNB3) were analysed. Paper-12836609. To investigate whether 5-HTT overexpression in PA-SMCs is sufficient to produce PH, we generated transgenic mice overexpressing 5-HTT under the control of the SM22 promoter. Paper-12018776. CONCLUSIONS: Weight reduction with sibutramine is associated with altered gastric functions and increased peptide YY and is significantly associated with SLC6A4 genotype. Paper-13335393. 5-hydroxytryptamine (5HT)-induced valvulopathy: compositional valvular alterations are associated with 5HT2B receptor and 5HT transporter transcript changes in Sprague-Dawley rats. Paper-12881564. HCR expressed higher levels of 5-HT1B autoreceptor mRNA in the raphe nuclei relative to LCR, but similar levels of TPH, 5-HTT, and 5-HT1A mRNA in these areas. Paper-12241720. Using the yeast two-hybrid approach we screened a human brain cDNA library and identified secretory carrier membrane protein 2 ( SCAMP2) as a novel SERT-interacting protein. Paper-12242696. Ninety-two Irish families, with a total of 106 proband-parent trios, have been genotyped for 3 previously known polymorphisms within hSERT (5-HTTLPR, intron 2 VNTR, and 3' UTR G/T). Paper-8525827. Confirmed association has been reported for several candidate genes, including DAT1, DRD4, SNAP-25, DRD5, 5HTT, HTR1B, and DBH; however, these confer relatively small risk. Paper-12566984. Phorbol esters, which trigger SERT phosphorylation, also diminish SERT/ PP2Ac associations, effects that can be blocked by PKC antagonists as well as the SERT substrate 5-HT. Paper-8747618. Similarly, protein phosphatase ( PP1/ PP2A) inhibitors down-regulate 5HT transport and significantly elevate hSERT 32P incorporation, effects that are additive with those of PKC activators. Paper-1321940. We recently identified three potential candidate genes that might be involved in DIE pain pathways: tyrosine kinase receptor B (TrKB), mu-opioid receptor ( MOR) and serotonin transporter ( 5HTT). Paper-12373920. These data indicate that region-specific changes in PD and c-fos expression occur after withdrawal, while SERT mRNA expression is suppressed, similar to what has been reported in MDD. Paper-13593738. A multivariate analysis using a mixed-effects model and including age, sex and predominant ethnicity as covariates was applied to the analyses of 5HTT LPR and DRD4 length polymorphism data. Paper-9908568. Interestingly, oligomerization was not confined to hSERT; fluorescence resonance energy transfer was also observed between CFP- and YFP-labeled rat gamma-aminobutyric acid transporter. Paper-8952395. Pooled data using a fixed-effects model suggested significant associations between the 5HTT LPR, DRD4 c>t, DRD4 length, DRD2 A1/A2, DRD3 A1/A2 polymorphisms and personality traits. Paper-9908568. Since tumor necrosis factor alpha ( TNF-alpha) and interleukin-6 are two inflammatory mediators that are central to the initiation of inflammation, we studied the impact of these cytokines on the 5-HTT. Paper-1643999. The main purpose of this study was to design potential new and selective PET radiotracers for the SERT and to predict their binding affinity at both the SERT and the norepinephrine transporter. Paper-11560209. The DRD2 TaqIA, exon 8, and promoter -141C ins/del polymorphisms as well as COMT Val158Met, 5HTT 44 bp del in promoter, and DAT 40 bp VNTR polymorphisms were detected by means of PCR. Paper-12725769. MDMA treatment significantly decreased (125)I-RTI-55 labeled SERT binding sites in the striatum, nucleus accumbens and cingulate cortex demonstrating a loss of 5-HT terminals. Paper-13084023. Appetite suppressants that increase the risk for developing primary pulmonary hypertension ( PPH) are all SERT substrates, but these drugs vary considerably in their propensity to increase this risk. Paper-9324622. METHODS: Striatal DAT and brainstem SERT were measured in 24 patients with schizophrenia and 22 matched healthy control subjects using single photon emission computed tomography and [(123)I]beta-CIT. Paper-2143421. No significant differences of the allelic distribution of genetic polymorphisms in the genes for 5HTT, NAT1, NAT2, PON1, PON2, and SOD2 were found between cases and controls. Paper-12843455. It is unknown, however, whether tegaserod interacts with the human serotonin reuptake transporter ( hSERT) and the uptake transporters for dopamine ( hDAT) and norepinephrine ( hNET). Paper-13415028. The Multifactor Dimensionality Reduction analysis was used to examine gene-gene interactions in serotonin system, including three other genes ( 5-HTT, 5-HT2A and MAOA) that we previously reported. Paper-13578352. Changes in the serotonin transporter ( SERT) have also been reported in MDD, and changes in the immediate early gene c-fos have been observed in the context of psychostimulant withdrawal. Paper-13593738. Lower brainstem serotonin and 5-hydroxyindoleacetic acid, fewer prefrontal serotonin transporter ( 5-HTT) sites and more post-synaptic 5-HT1A and 5HT2A receptors were reported in suicide. Paper-12219035. Co-expression of SERT and SCAMP2 in mammalian cells results in the subcellular redistribution of SERT with a decrease in cell surface SERT and a concomitant reduction in 5-HT uptake activity. Paper-12242696. By inhibiting SERT and increasing local 5-HT concentrations in the gut wall, tegaserod might exert its prokinetic action via a synergism between 5-HT4 agonism and low-affinity SERT inhibition. Paper-13415028. This downregulation of 5-HTT by fluoxetine and its enhancement by Org 34850 can explain our recent observation that GR antagonists augment the SSRI-induced increase in extracellular 5-HT. Paper-13075656. Haplotypes at SLC6A4 and individual genotypes of polymorphisms at SLC6A4, HTR7, HTR2A, ITGB3, and TPH1 showed no significant association with whole blood 5-HT. Paper-12660183. Alleles of the serotonin transporter gene ( SERT) and the dopamine 4 receptor gene ( DRD4) were first associated with anxiety-related and novelty-seeking personality traits, respectively, in 1996. Paper-10648866. The FKBP5 (FK506-binding protein gene), SERT ( serotonin transporter gene) and COMT ( catechol-o-methyltransferase gene) mRNA expressions in the leukocytes were determined with hormonal data. Paper-12768538. Here we have investigated whether other members of the synuclein family of proteins, gamma-synuclein (gamma-Syn) and beta-synuclein (beta-Syn) can similarly modulate the serotonin transporter ( SERT). Paper-13764183. Since there has been no survey in this regard from India, a sample of 56 ADHD cases and 174 healthy individuals from Kolkata were genotyped for the SLC6A4 promoter (5-HTTLPR) and intron-2 (STin2) polymorphisms. Paper-12018629. In vitro, AFA displayed high affinity for SERT (Ki 1.46 +/- 0.15 nM) and lower affinity for norepinephrine transporter (NET, Ki 141.7 +/- 47.4 nM) or dopamine transporter ( DAT, Ki > 10,000 nM). Paper-10533100. The polymorphisms under investigation were the 5-HTTLPR, the VNTR in intron 2 and the 3'UTR SNP in 5-HTT, the 5- HTR1B variations 861G>C and 102T>C, and the 5- HTR2A variations His452Tyr and 1438G>A. Paper-12468342. CONCLUSIONS/SIGNIFICANCE: Based on our findings, we propose that phosphate modification of the SITPET sequence differentially, one at a time exposes the vimentin binding domain on the C-terminus of SERT. Paper-13654445. Syntaxin 1A is a component of the synaptic vesicle docking and fusion apparatus and has been shown to interact with multiple plasma membrane neurotransmitter transporters including SERT. Paper-12994707. Uptake and superfusion experiments were performed on human embryonic kidney 293 cells permanently expressing the hSERT using [(3)H]serotonin ( 5-HT) and [(3)H]1-methyl-4-phenylpyridinium ( MPP(+)) as substrates. Paper-8768190. These studies provided evidence for distinct binding sites coordinating SERT antagonists and revealed a close interaction between TM1 and TM3 differentially targeted by stereoisomers of CIT. Paper-10830089. Lastly, the involvement of genes whose products are already the targets for approved drugs, such as SLC6A4, PPARalpha and PPARgamma , in the development of CMS suggests new avenues for CMS pharmacological treatment. Paper-13472860. A series of 4-[2-[bis(4-fluorophenyl)methoxy]ethylpiperidines were examined for their ability to bind to the dopamine transporter ( DAT), the norepinephrine transporter, and the serotonin transporter ( SERT). Paper-9547707. A series of N-8-substituted benztropinamines was synthesized and evaluated for binding at the dopamine ( DAT), serotonin ( SERT), norepinephrine (NET) transporters, and muscarinic M1 receptors. Paper-11483824. These two SERT-conducting states are present endogenously in thalamocortical neurons, act to depolarize the membrane potential, and are modulated by molecules that disrupt SERT and syntaxin 1A interactions. Paper-10167269. Selective serotonin transporter ( SERT) inhibitors were also effective in reducing cocaine use and blocked cocaine- induced brain activation and increases in extracellular dopamine. Paper-13509264. With the exception of the hypoglossal nucleus, where 5-HT1A receptor binding increases while SERT binding remains stable, the medullary 5-HT markers analyzed in the study are essentially "in place" at birth. Paper-10276244. The goal of this study was to elucidate whether the 5-HTTLPR polymorphism is associated with the mirtazapine antidepressant response in subjects with major depressive disorder ( MDD). Paper-13355087. The increased expression of 5-HTT in hypoxic cells was associated with a greater mitogenic response to 5-HT (10(-8) to 10(-6) mol/L) in the absence as well as in the presence of platelet-derived growth factor-BB. Paper-1751542. Drawing on the life course perspective, we predicted a stronger association between the polymorphisms in 5HTT, DAT1, DRD4, DRD2, and MAOA and alcohol consumption in young adulthood than adolescence. Paper-13261688. While in healthy controls prefrontal (BA10) activation and BA10-amygdala coupling increased with the number of 5-HTT low-expression risk alleles, this effect was abolished, and even reversed, in patients with MDD. Paper-13873977. In population-based sub-analyses, we found significant results in four genes in Asians (ORs between 1.084 and 1.309 for DRD4, GABRB2, PPP3CC, and TP53), and one gene in European (OR of 0.888 for SLC6A4). Paper-12982428. In contrast, after an excessive training program over four weeks, well-trained endurance athletes showed no change of Bmax of 5-HTT, but a decline of 5-HT(2A)R density and an increase in basal plasma PRL concentration. Paper-8829672. We found no evidence for an allelic association of either the silent G603A substitution polymorphism in exon 5 of the EAAT2 gene or the regulatory promoter polymorphism of the SERT gene with either IGE or IAE. Paper-8654361. Pet-1 and 5-HTT mRNA levels were quantified throughout the dorsal and median raphe nuclei (DRN and MRN) by conducting in situ hybridization on free-floating tissue sections using (35)S-labeled cDNA probes. Paper-13655734. CONCLUSION: The association between polymorphisms in serotonergic genes ( SERT and 5-HT2A, 5-HT2C) suggests that these genetic factors can modulate vulnerability to puerperal psychosis in female bipolar participants. Paper-13411549. Five other transporters were downregulated; aquaporin 10, SLC6A4, TRPM6, SLC23A1 and SLC30A4, which have specificity for water, serotonin ( 5-HT), magnesium, vitamin C and zinc, respectively. Paper-13321594. Highly efficient acetylcholinesterase ( AChE) and serotonin transporter ( SERT) dual inhibitors, (S)-4 and (R)-13 were designed and synthesized on the basis of the hypothetical model of AChE active site. Paper-9239695. No significant evidence of association or linkage was found at any of the markers tested, indicating that the 5-HTT and the GABRB3 genes are unlikely to play a major role in the aetiology of autism in our family data set. Paper-8332948. Our most intriguing result involved three SNPs in the TPH1 gene and one SNP in the SLC6A4 gene, which show significant single-locus association when response to fluoxetine is compared to nonresponse (P=0.02-0.04). Paper-10642926. Chase studies with the SERT ligand 15 displaced [(18)F]1-[(18)F]4, but chase studies with the DAT ligand 16 did not displace [(18)F]1-[(18)F]4 thus indicating that the tracers were binding specifically to the SERT. Paper-13511217. Maternal accounts of temperament and observed response to novelty were investigated for 90 infants, who were independently genotyped for the DRD4 III exon, and for 5-HTT-linked promoter region length polymorphisms. Paper-9660788. Because hypoxia and 5-HTT gene polymorphism control 5-HTT expression, we examined 5-HTT gene polymorphism and PH in hypoxemic patients with advanced chronic obstructive pulmonary disease ( COPD). Paper-10031703. Here we demonstrate that expression of the organic cation transporter type 3 ( OCT3, SLC22A3), which also transports 5-HT, is upregulated in the brains of mice with constitutively reduced 5-HTT expression. Paper-13476234. These data show that testosterone as well as estrogen affects SERT expression in male brain, and that the action of testosterone probably depends upon its enzymatic conversion, by aromatase, to estradiol. Paper-1725338. Functional expression of the unglycosylated SERT mutant, SERT-QQ, was also increased on co-expression of calnexin, suggesting that the interaction between calnexin and SERT is not entirely dictated by the N-glycan. Paper-1899977. The different 5-HT ( serotonin) receptors including the serotonin transporter ( 5-HTT) are candidate genes for affective disorders such as major depressive disorder ( MDD) and bipolar disorder (BD). Paper-9921213. The integrin beta3 ( ITGB3) and serotonin transporter ( SLC6A4) genes were both recently identified as male quantitative trait loci (QTLs) for serotonin levels and alleles of each have been associated with autism. Paper-12139528. Individual differences in brain response to emotional stimuli have previously been associated with gene variations within the serotonin transporter ( 5-HTT) and tryptophan hydroxylase-2 ( TPH2) genes. Paper-12896872. The review of association studies gave interesting results, as a number of genes seem to be definitively involved in BP, such as SLC6A4, TPH2, DRD4, SLC6A3, DAOA, DTNBP1, NRG1, DISC1 and BDNF. Paper-12935992. As the 5-HTTLPR polymorphism was significantly associated with an increased risk of major depressive disorder, the 5-HTT gene may be a candidate for a major depressive disorder susceptibility gene. Paper-13865065. An hSERT mutant with single cysteine substitutions in TM1 and TM3 resulted in formation of a high affinity cadmium metal coordination site, suggesting proximity of these domains in the tertiary structure of SERT. Paper-10830089. Using confocal microscopy we show that in neuronal cells endogenous SERT co-localizes with SCAMP2 in discrete structures also containing the lipid raft marker flotillin-1 and the SNARE protein syntaxin 1A. Paper-12242696. Furthermore, only the constructs encoding the NAC domain of alpha-Syn prevented the co-IPs between full-length alpha-Syn and SERT, in both transfected cells and in rat solubilized lysates isolated from the prefrontal cortex. Paper-12077828. The aim of this study was to determine whether there were any associations between polymorphisms within the ACE, BDKRB2, NOS3 and/or 5-HTT genes with weight changes during the 2000 and 2001 226 km South African Ironman Triathlons. Paper-12251798. A series of 4-[2-[bis(4-fluorophenyl)methoxy]ethyl-1-benzylpiperidines were examined for their ability to bind to the dopamine transporter ( DAT), the serotonin transporter ( SERT), and the norepinephrine transporter (NET). Paper-9875884. We examined the possible influence of the long (A/G) variant on 5-HTT density in the living human brain using 3-(11)C-amino-4-(2-dimethylaminomethylphenyl-sulfanyl) benzonitrile ([(11)C]DASB) positron emission tomography. Paper-13372223. However, during the HTT there were no overall differences (P > 0.05) in HR, Tre, Tsk, RPE, thermal sensations, or HTT time (ORAL, 71 +/- 8 min; IV, 73 +/- 5 min; NF, 39 +/- 29 min) between the ORAL and IV treatments. Paper-12345887. Here, we used yeast 2-hybrid screening and cotransfection into 293 cells to identify a homologue of the myristoylated alanine-rich C kinase substrate ( MARCKS), MacMARCKS, as a C-terminally interacting protein of SERT. Paper-9480661. No significant differences in genotype distribution or allele frequencies were identified for 5-HTTLPR or 5-HTTVNTR between AD patients and age- and sex-matched non-demented controls regardless of ApoE epsilon4 allele. Paper-12631085. Genetic polymorphisms in several genes ( TPH2, SLC6A4, HTR1A, HTR2A, COMT, and BDNF) were tested as predictors of relapse (defined as any drinking during follow-up) while controlling for baseline measures. Paper-13694153. In this study we used in situ hybridization and real-time PCR to study the gene expression of monoamine transporters, such as NET, SERT, VMAT2, EMT and OCT1/2, in normal as well as in pre-eclamptic placentae. Paper-10425201. The evidence for an effect of specific genes was modest, however, and evidence indicated substantial between-study heterogeneity in most cases, with the exception of the effects of the 5HTT and CYP2A6 genes on smoking cessation. Paper-10906688. In particular, studies on blood-borne neutral amino acids and platelet serotonin transporter ( SERT) in epileptics suggest: (a) That a decreased brain availability of tryptophan may be related to some types of epilepsy. Paper-12119599. Thus, the binding data show that this conformation is recognized by the DAT- associated binding site and also suggest that this conformation of paroxetine is recognized by the 5-HTT-associated binding site. Paper-1327331. Findings are discussed considering the metabolic association among DAT, 5-HTT and MAOA with special emphasis on the linked action of 5-HTT/ MAOA in regulating serotonin metabolism of SIDS and SIUD infants. Paper-13539561. METHODS AND RESULTS: The SLC6A4 polymorphism has been investigated by polymerase chain reaction in 671 male patients with MI and in 688 controls from the Etude Cas-Témoins de l'Infarctus du Myocarde (ECTIM) multicentric study. Paper-9494516. When expressed in human embryonic kidney 293 cells, the resulting fusion proteins ( CFP- hSERT and YFP- hSERT) were efficiently inserted into the plasma membrane and were functionally indistinguishable from wild-type hSERT. Paper-8952395. Specific cell surface receptors are now known to regulate SERT trafficking and/or catalytic function, with pathways activating protein kinase C, protein kinase G and p38 mitogen-activated protein kinase receiving the greatest attention. Paper-13025323. Potential relevant OCD phenotypes founded on age of onset, positive family history for OCD, clinical subtypes, comorbidity and symptom severity were stratified according to 5-HTT, 5-HT1B and 5-HT2A genotypes. Paper-11345251. The ratio of 5-HTT binding density to 5-HT neuron count in the medulla was significantly lower in SIDS cases compared with controls (mean [SD], 0.70 [0.33] vs 1.93 [1.25] fmol/mg, respectively; P = .001). Paper-12299726. In the present study we investigated to which degree polymorphisms in the 5-HTT and AP-2beta genes are implicated in the neural processes involved in the formation of Temperament and Character traits, as estimated by Cloninger's TCI. Paper-12372369. Serotonin transporter ( SLC6A4) polymorphisms are variously implicated in mediating susceptibility to attention-deficit-hyperactivity disorder ( ADHD), a highly heritable and heterogeneous disorder with onset in childhood. Paper-12018629. In this family-based association study of DRD2, DRD4, DAT, and SERT, the distribution of parental nontransmitted alleles was compared with that of alleles transmitted to 53 Sardinian probands suffering from bipolar disorder. Paper-8332953. These data show that in vitro and in vivo exposure to hypoxia induces, via a transcriptional mechanism, 5-HTT expression in PA-SMCs, and that this effect contributes to the stimulatory action of 5-HT on PA- SMC proliferation. Paper-1751542. BACKGROUND: Although brain serotonin transporter ( 5-HTT) density has been investigated in subjects with a history of major depressive episodes (MDE), there has never been an investigation of brain 5- HTT during a current MDE. Paper-10616900. Wild type (WT, C57 background), heterozygous ( SERT +/-, HET) mice and homozygous knockout ( SERT -/-, KO) were assigned to handled control groups or groups exposed for 10min to a large testing room rich in cat odor. Paper-11833720. In the poly I:C-induced fatigue rats, expression of IFN-alpha and 5-HTT increased, while extracellular concentration of 5-HT in the medial prefrontal cortex decreased, probably on account of the enhanced expression of 5-HTT. Paper-12367708. Compared with control subjects, platelet 5-HTT protein was increased in COPD patients in proportion to the hypoxemia level, and strong 5-HTT immunostaining was observed in remodeled pulmonary arteries from COPD patients. Paper-10031703. As compared with controls, the expression of 5-HTT was increased in cultured PA-SMCs as well as in platelets and lungs from patients with PPH where it predominated in the media of thickened pulmonary arteries and in onion-bulb lesions. Paper-9047875. The combined evidence was significant for association with the 5-HTT locus (Mantel-Haenszel weighted odds ratio (M-H(w) OR)=1.17 CI : 1.04-1.32, P=0.009), but not for the 5-HT2A 102 T/C variant (M-H(w) OR)=1.09 CI : 0.93-1.27, P=0.319). Paper-9932275. Following gene polymorphisms were determined by the PCR method: ACE insertion/deletion (I/D ACE), angiotensinogen ( AGT) (M 235), angiotensin II receptor ( ATR1) (A 1166C) and serotonin transporter ( SERT) polymorphism (5HTTLPR). Paper-13747103. We analyzed five chromosomal regions surrounding the candidate genes 5HT1D (1p36.3-34.3), 5HT1B (6q13), 5HT2A (13q14-21), 5HT transporter (17q11.2-12), CACNLB1 (17q11.2-22) and FHM (19p13), using 29 DNA polymorphic markers. Paper-1286483. SERT binding levels in PD were lower than those in controls in all examined brain areas, with the changes statistically significant in orbitofrontal cortex (-22%), caudate (-30%), putamen (-26%), and midbrain (-29%). Paper-13186884. We hypothesized that a reduced antidepressant response in individuals with a constitutive reduction in 5-HTT expression could arise because of the compensatory expression of other genes that inactivate 5-HT in the brain. Paper-13476234. Statistically significant associations were found for the APOE varepsilon2 (OR, 0.51), GNB3 825T (OR, 1.38), MTHFR 677T (OR, 1.20), SLC6A4 44 bp Ins/Del S (OR, 1.11) alleles and the SLC6A3 40 bpVNTR 9/10 genotype (OR, 2.06). Paper-12935989. Several studies have reported an association of this gene to ADHD, specifically the long variant of a common insertion/deletion polymorphism located in the promoter of this gene that results in increased transcription and higher HTT expression. Paper-12199565. Two proteins that influence the function of serotonin and serotonergic receptors are serotonin transporter protein ( SERT or soluble carrier protein, SLC6A4) and p11 (S-100A10, or calpactin I light chain). Paper-12435341. METHODS: We evaluated the role of three polymorphic genes related to alcohol metabolism ( CYP2E1) and, possibly, dependence ( DRD2 and SLC6A4 promoter) in a series of 60 alcoholics admitted to a specialized referral center in Florence, Italy. Paper-8710202. We report a significant main effect of the HTR5A gene in autism (P = 0.0088), and a significant three-locus model comprising a synergistic interaction between the ITGB3 and SLC6A4 genes with an additive effect of HTR5A (P < 0.0010). Paper-13150896. These transporters for dopamine ( DAT), serotonin ( SERT), and norepinephrine (NET), which are expressed selectively on the corresponding neurons, are established targets of many psychostimulants, antidepressants, and neurotoxins. Paper-9807525. Therefore, we propose that under uncontrolled diabetic conditions, glucose down-regulates 5HT uptake rates of placental SERT by interfering with its functional expression in a cell-cycle-dependent manner. Paper-13212527. On the other hand, melatonin, 5-MI-3-AA, NA- 5-HTT, 5-MTT, 5-MTP, HVA, 5-HI-3-AA, VMA, DOPAC, 5-hydroxytryptophol, and MN, but not 3-MT, DHMA, and NMN, at 2 mM, inhibited estrone sulfate uptake mediated by hOAT3. Paper-10175175. Objective: We examined the relationship between platelet 5-HTT, a presynaptic 5-HT measure, and prolactin ( PRL) response to meta-chlorophenylpiperazine (m-CPP), a postsynaptic 5-HT receptor agonist in cocaine dependent individuals. Paper-13038410. Two SERT ligands, AFM ([(3)H]2-[2-(dimethylaminomethylphenylthio)]-5-fluoromethylphenylamine) and DASB ([(3)H]3-amino-4-[2-(dimethylaminomethylphenylthio)]benzonitrile), have recently been developed for positron emission tomography (PET) imaging. Paper-10205843. Previous studies have suggested that the serotonin transporter ( 5-HTT) gene and the gamma-aminobutyric acid receptor subunit beta3 ( GABRB3) gene, or other genes in the 15q11-q13 region, are possibly involved in susceptibility to autism. Paper-8332948. Using functional magnetic resonance imaging, we assessed the effects of COMT Val(158)Met and both 5-HTT genotypes on brain activation by standardized affective visual stimuli (unpleasant, pleasant, and neutral) in 48 healthy subjects. Paper-13132305. Many studies investigated the association between MDD and BD with the 5-HT2A 102 T/C, the 5-HTT promoter 44 bp insertion/deletion and the intron 2 VNTR polymorphisms, and thus, these could be pooled using meta-analytic techniques. Paper-9921213. Then three-dimensional models of the neurotransmitter transporters hDAT, hSERT and hNET were constructed based on the NhaA model and studies of ligand binding to mutated dopamine transporter ( DAT) and serotonin transporter ( SERT). Paper-12104578. We screened for variants in the complete coding sequence and intron-exon junctions of two candidate genes for neuropsychiatric phenotypes: SLC6A4, encoding the serotonin transporter; and SLC18A2, encoding the vesicular monoamine transporter. Paper-8713746. PURPOSE OF THE STUDY: The G482T and G689T polymorphisms in the 3'-UTR of serotonin transporter ( SLC6A4) are implicated in translational regulation and allelic variants may mediate susceptibility to attention-deficit-hyperactivity disorder ( ADHD). Paper-13764215. The serotoninergic system is believed to be involved in suicidal behavior and there is evidence of biological abnormalities of two serotonin receptors ( HTR2A, HTR2C) and one serotonin transporter ( 5HTT) in suicide victims. Paper-12725775. The findings, that D4DR exon III and 5-HTT promoter genotypes and trbc-MAO activity are related to human fear conditioning, a basic form of associative learning, are consistent with animal studies suggesting a genetic contribution to fear conditioning. Paper-8832063. Previously reported positive associations between DRD2 or SERT and bipolar disorder were conceivably due to stratification dependent on the case-control design, even though our sample might have failed to detect small associations due to limited power. Paper-8332953. OBJECTIVE: To study the association between the occurrence of migraine with aura and 5-HT(1B/ 1D) and 5-HT(2C) receptor gene and the human serotonin transporter ( hSERT) gene polymorphisms in 18 unrelated families with multiple affected members. Paper-10338641. Previous studies showed that the mixed monoamine transporter inhibitor (6, RTI-112) reduced cocaine self-administration at a high level of serotonin transporter ( 5-HTT) occupancy with no detectable dopamine transporter ( DAT) occupancy. Paper-13511193. CONCLUSION: Our data do not support the involvement of 5-HT(1B/ 1D) and 5-HT(2C) receptor gene polymorphisms in migraine with aura, yet do suggest a possible role for a locus at or near the hSERT gene in the susceptibility to migraine with aura. Paper-10338641. No changes occurred in hypothalamic mRNA expression for AGRP, NPY, HCRT, CRH, IL-1, IL-6, TNFalpha, ABCG1, SLC6A4, PPIA and HPRT mRNA but tryptophan hydroxylase ( TPH) mRNA was decreased (47%, P < 0.05) at day 21 post-CP. Paper-11381458. Four potent DAT inhibitors, with relatively high norepinephrine transporter, but low SERT affinities, that occupied the DAT improved activity in parkinsonian monkeys, whereas three high-affinity DAT inhibitors with low DAT occupancy did not. Paper-12270069. Transport by AaLeuT is Cl(-) independent, whereas many neurotransmitter:sodium symporters like serotonin transporter ( SERT), GABA transporter ( GAT1), dopamine transporter and norephinephrine transporter, among others, are strongly Cl(-) dependent.(4). Paper-13499247. While mean velocities of 5HTT kinetics did not significantly differ among the groups, significant elevation in the mean velocity of MAOB kinetics was observed in NS subjects and was even more pronounced in HS subjects in comparison to controls. Paper-13721163. In a clinical sample of 266 children with ADHD, we tested for interaction between gene variants (in DRD4, DAT1, DRD5, and 5HTT) found to be associated with ADHD in pooled analyses and maternal smoking, alcohol use during pregnancy and birth weight. Paper-12671896. When not bound to syntaxin 1A, SERT shows both substrate-independent Na(+) fluxes and substrate-dependent Na(+) fluxes of variable stoichiometry; these fluxes are eliminated in the presence of syntaxin 1A as Na(+) flux becomes strictly coupled to 5HT uptake. Paper-12994707. In vivo, we determined DAT and NET occupancy by modafinil by positron emission tomography imaging; in vitro, we determined modafinil activity at the DAT, NET, SERT, and rhesus monkey trace amine receptor 1 ( TA1). Paper-12270068. The aim of this study was to investigate seven genetic variants in three genes ( serotonin transporter ( 5-HTT), serotonin receptor 1B (5- HTR1B) and serotonin receptor 2A (5- HTR2A)), which have previously been shown to be associated with ADHD. Paper-12468342. The mitogenic effect of serotonin on pulmonary vascular smooth muscle cells is mediated by the serotonin transporter (5-hydroxytryptamine transporter [ 5-HTT]), whereas its constricting effect is mediated by 5-HT1B/1D and 5-HT2A receptors. Paper-9826053. We collected 225 independent subjects (74 sporadic FTLD and 151 age-matched healthy controls, CT) that were genotyped for the rs4795541, the SLC6A4 single nucleotide polymorphisms (SNP) rs25531 and rs6354, and the apolipoprotein E ( APOE) allelic variants. Paper-13483063. To examine further the putative relationship between estradiol and 5-HT, we investigated whether estradiol increases the expression of Pet-1 and the 5-HT transporter ( 5-HTT), two genes implicated in the development and regulation of the 5-HT system. Paper-13655734. A 19 bp insertion/deletion polymorphism in the dopamine beta-hydroxylase ( DBH) gene, the apolipoprotein ( APOE) varepsilon2/varepsilon3/varepsilon4 variation and 5-HTTLPR in the serotonin transporter gene were genotyped. Paper-12675802. Molecular polymorphisms are discussed considering their functional role in regulating serotonin synthesis ( TPH2), neuronal reuptake (5-HTTLPR and 5-HTT intron 2), and catabolism ( MAOA) in the nervous system of Italian SIDS infants. Paper-12820474. In the present study, we investigated the distribution and overlap of OT- labeled cells and serotonin transporter ( 5-HTT) immunoreactive (IR) fibers in the Macaque hypothalamus, utilizing immunocytochemical and double-immunofluorescent techniques. Paper-13190714. Because of an interaction between the serotonin ( 5-HT) and DA systems, the serotonin transporter gene ( SLC6A4) has been considered as a candidate ADHD susceptibility gene. Paper-11531107. The negative modulation of SERT activity by alpha-Syn occurred through the non-Abeta-amyloid component ( NAC) domain of alpha-Syn (aa58-107); DNA constructs encoding this region mimicked the full-length alpha-Syn protein by decreasing [(3)H]5-HT uptake by the transporter. Paper-12077828. The serotonin transporter gene ( SLC6A4, MIM 182138) is a candidate gene in autistic disorder based on neurochemical, neuroendocrine studies and the efficacy of potent serotonin transporter inhibitors in reducing ritualistic behaviors and related aggression. Paper-9201051. The cGKs have been suggested to modulate cytoskeletal organization, vesicle and AMPA receptor trafficking, and gene expression via phosphorylation of various substrates including VASP, RhoA, RGS2, hSERT, GluR1, G-substrate, and DARPP-32. Paper-13497208. METHODS AND RESULTS: In 103 patients with COPD recruited in France (n=67) and the UK (n=36), we determined 5-HTT gene polymorphism and pulmonary artery pressure (PAP) measured during right heart catheterization (France) or Doppler echocardiography (UK). Paper-10031703. Association was also observed between Tellegen Absorption Scale scores and AVPR1a (Qtdtphase: global chi-square = 26.53, p = 0.047), SLC6A4 haplotypes (Qtdtphase: chi-square = 2.363, p = 0.018), and AVPR1a conditional on SCL6A4 (Tdtphase: LRS = 250.44, p = 0.011). Paper-11479782. At 8 weeks of age, SM22- 5-HTT(+) mice exhibited PH, with marked increases in right ventricular systolic pressure (RVSP), right ventricle/left ventricle+septum ratio, and muscularization of distal pulmonary vessels, but no changes in systemic arterial pressure. Paper-12018776. Modafinil did not activate the TA1 receptor in TA1-HEK cells, but it augmented a monoamine transporter-dependent enhancement of phenethylamine activation of TA1 in TA1- DAT and TA1-NET cells, but not in TA1- SERT cells. Paper-12270068. Common alleles of some serotonin pathway genes, including those involved in its degradation ( monoamine oxidase A, MAOA), or its re-uptake into pre-synaptic neurones ( serotonin transporter, SERT) have been shown to confer functional variation. Paper-13115644. This effect was dependent on the 5-HT transporter ( 5-HTT), since it was prevented by the 5-HTT inhibitors fluoxetine (10(-6) mol/L) and paroxetine (10(-7) mol/L), but it was unaltered by ketanserin (10(-6) mol/L), a 5-HT2A receptor antagonist. Paper-1751542. Association studies are summarized, which support a possible role for numerous candidate genes in BPD including COMT, DAT, HTR4, DRD4, DRD2, HTR2A, 5-HTT, the G72/ G30 complex, DISC1, P2RX7, MAOA and BDNF. Paper-11317874. Multiple 'variability genes' were found for longitudinal change in a semantic memory task including candidates coding for apolipoprotein E ( APOE) and estrogen receptor alpha ( ESR1) as well as serotonin candidates ( HTR2A and 5HTT). Paper-13287980. Several studies have attempted to confirm an association between a deletion/insertion polymorphism within the promoter region of the serotonin transporter gene ( 5-HTT) and Alzheimer's disease independent from the apolipoprotein E ( APOE) varepsilon4 status. Paper-8457398. A single amino acid mutation, cysteine-201 to alanine, within the conserved cytoplasmic E peptide of SCAMP2, abolished SCAMP2- mediated down-regulation of SERT, although this mutation had no effect on the physical interaction between SERT and SCAMP2. Paper-12242696. Polymorphisms in the following genes were studied: tryptophan hydroxylase ( TPH), serotonin 2A receptor ( HTR2A), serotonin 2C receptor ( HTR2C), serotonin transporter ( 5-HTT), dopamine receptor D4 ( DRD4), and dopamine transporter ( DAT1). Paper-8398131. This paper considers the possible involvement of genes that may be involved in physiological adaptation to hypoxia (e.g., angiotensin-1 [AT(1)]-converting enzyme [ACE], tyrosine hydroxylase, serotonin transporter [ 5-HTT], and endothelial NO synthase [ eNOS] genes). Paper-10268295. Serotonin (5-HT)-positive cells were counted and the mRNA levels of tryptophan hydroxylase ( TPH), serotonin transporter ( SERT), 5-HT(4) receptor and 5-HT(3) receptor subunits were quantified by real-time reverse transcription polymerase chain reaction. Paper-13245557. The 5HT transporter ( SERT) on the membranes of the placental trophoblast cells controls 5HT levels in the maternal bloodstream to maintain stable transplacental blood flow and simultaneously provide 5HT to the embryo. Paper-13212527. The role in autism etiology of seven candidate genes in the serotonin metabolic and neurotransmission pathways and mapping to autism linkage regions ( SLC6A4, HTR1A, HTR1D, HTR2A, HTR5A, TPH1 and ITGB3) was analyzed in a sample of 186 nuclear families. Paper-13150896. This study is a comprehensive analysis of genetic diversity in HTT and reveals that HD patients of European origin (n = 65) have a significant enrichment (95%) of a specific set of 22 tagging single nucleotide polymorphisms ( SNPs) that constitute a single haplogroup. Paper-13662048. The in vitro binding studies in cells transfected with human SERT, norepinephrine transporter (NET), and dopamine transporter ( DAT) showed that 35, 36, and 37 exhibited high SERT affinity with K is ( SERT) = 1.26, 0.29, and 0.31 nM (vs [ (3)H]citalopram), respectively. Paper-12694639. In the current study, 85 current performing dancers and their parents were genotyped for the serotonin transporter ( SLC6A4: promoter region HTTLPR and intron 2 VNTR) and the arginine vasopressin receptor 1a (AVPR1a: promoter microsatellites RS1 and RS3). Paper-11479782. One common polymorphic variant of the 5-HTT- linked polymorphic region ( 5-HTTLPR), which affects the promoter of the 5-HTT gene, causes reduced uptake of the neurotransmitter serotonin into the presynaptic cells in the brain. Paper-13865065. We have demonstrated that activation of p38 mitogen- activated protein kinase ( MAPK) induces a catalytic activation of the serotonin transporter ( SERT) arising from a reduction in the SERT K(m) for 5-hydroxytryptamine ( 5-HT). Paper-12232665. To test this possibility, data from the National Longitudinal Study of Adolescent Health (Add Health) were used to examine the effects that five different genetic polymorphisms ( DAT1, DRD2, DRD4, 5HTT, and MAOA) have on desistance from delinquent involvement. Paper-13502530. They have tested hypotheses involving key candidate genes in the serotonin ( 5-HTT), dopamine ( DRD2, DAT), glucocorticoid ( GR), GABA ( GABRB), apolipoprotein systems (APOE2), brain-derived neurotrophic factor ( BDNF) and neuropeptide Y ( NPY). Paper-13119087. Whereas, the 5-HT1A receptor genotype did not show any significant effects on [11C]WAY 100635 binding, 5-HT1A receptor binding potential values were lower in all brain regions in subjects with 5-HTTLPR short (SS or SL) genotypes than those with long (LL) genotypes. Paper-11085738. Neuroendocrine cells, specifically 5-HT producing cells, were counted after immunohistochemistry, and non-neuronal mRNA expression levels of tryptophan hydroxylase (TPH)-1, 5-HT transport protein ( SERT), 5-HT3 and 5-HT4 receptor were quantified by real time RT-PCR. Paper-12783482. In addition, the cell lines MEL- SERT, Imi270 and T-REx-SERT all expressed fully N-glycosylated SERT and no unglycosylated inactive protein, in contrast to the baculovirus expression system where the vast majority of expressed SERT was unglycosylated and nonfunctional. Paper-9678806. These data provide in vivo evidence of biologic epistasis between SLC6A4 and BDNF in the human brain by identifying a neural mechanism linking serotonergic and neurotrophic signaling on the neural systems level, and have implications for personalized treatment planning in depression. Paper-12836493. In the present study, we aimed to analyze the potential relevance of the polymorphism in the promoter region of the serotonin transporter ( SERT or 5-HTT) gene (5-HTTLPR) and the risk of suffering major depression (MDD) in a population of patients previously genotyped for CYP2C9. Paper-13343691. Here, we confirm that the norepinephrine (NET), the serotonin ( SERT), the dopamine ( DAT) uptake transporters and MAO activity are inhibited by EGb761((R))in vitro, although rather high concentrations are required for inhibition of MAO-A and MAO-B activity. Paper-13761815. Here we found that PA-SMCs from patients with PPH grow faster than PA-SMCs from controls when stimulated by serotonin or serum and that these effects are due to increased expression of the serotonin transporter ( 5-HTT), which mediates internalization of indoleamine. Paper-9047875. Human serotonin [5-hydroxytryptamine ( 5-HT)] transporters ( hSERT, 5HTT, and SLC6A4) inactivate 5-HT after release and are prominent targets for therapeutic intervention in mood, anxiety, and obsessive-compulsive disorders. Paper-11047657. METHODS: Tegaserod inhibition of SERT- mediated [3H]5-HT and NET- and DAT- mediated [3H]dopamine uptake was measured in human embryonic kidney (HEK) 293 cells stably expressing hSERT, hDAT, and hNET in comparison with untransfected control HEK293-FT cells. Paper-13415028. Pretreatment with methylphenidate reduced the specific binding of [99mTc]TRODAT-1 to DAT sites [(STR-CB)/CB] from 2.45+/-0.13 to 0.32+/-0.04 without any effect on its binding to SERT sites [(MB-CB)/CB], which was confirmed by the co-registration of the [11C](+)McN5652/ PET scans. Paper-1847450. We administered nicotine to rats throughout gestation or in adulthood (postnatal days PN90-107), using regimens that reproduce plasma levels in smokers, assessing effects on serotonin (5HT) receptors, the 5HT transporter and responses mediated through adenylyl cyclase ( AC). Paper-13285473. Measures of psychiatric symptomatology and social supports were obtained using standard research instruments, and serotonin transporter (5-HTTLPR) (locus SLC6A4) and brain-derived neurotrophic factor ( BDNF) (variant val66met) genotypes were obtained from saliva-derived DNA specimens. Paper-11307101. In the present study, we investigated whether 7-day 5HT subcutaneous injections led to structural and compositional abnormalities in conjunction with transcriptomic modulation of 5HT2BR and 5HT transporter ( 5HTT) genes in the aortic and mitral valves of Sprague-Dawley (SD) rats. Paper-12881564. CONCLUSION: These findings suggest that increased medial prefrontal (BA10) activation and BA10-amygdala connectivity may counteract the risk for MDD in healthy carriers of 5-HTT low-expression alleles, while this protective factor might be lost in patients who actually suffer from MDD. Paper-13873977. MAIN OUTCOME MEASURES: 5-HT neuron count and density, 5-HT(1A) receptor binding density, and 5-HT transporter ( 5-HTT) binding density in the medullary 5-HT system; correlation between these markers and 6 recognized risk factors for SIDS. Paper-12299726. Genotyping HD patients for DRD4 and 5-HTT polymorphisms and measuring PL concentrations, we report on an association between the combination DRD4*7/ 5HTT LL genotype and a reduced improvement in general functioning accompanied by different PL levels upon MPH treatment. Paper-9085834. One hundred and eleven male patients with alcohol dependence and 123 nonalcoholic healthy men were tested for the genetic polymorphisms of alcohol dehydrogenase 2 ( ADH2), aldehyde dehydrogenase 2 ( ALDH2), serotonin transporter ( 5-HTT) and dopamine transporter ( DAT1). Paper-11328857. Differential sampling procedures may influence the proportion of AAO subgroups in a given association study, and therefore these results may explain the conflicting results obtained in studies of the association between the SLC6A4 gene polymorphism and bipolar affective disorder ( BPAD). Paper-9269039. Furthermore, binding of [(11)C]AFM in SERT-rich regions was blocked by the cold compound AFM and the selective serotonin reuptake inhibitor citalopram but not by the selective norepinephrine reuptake inhibitor nisoxetine or the selective dopamine reuptake inhibitor GBR 12935. Paper-10525114. Using a high-throughput single-nucleotide polymorphism (SNP) genotyping platform and capillary electrophoresis, we genotyped patients at 110 SNPs and four repeat polymorphisms located in seven candidate genes ( HTR1A, HTR2A, HTR2C, MAOA, SLC6A4, TPH1, and TPH2). Paper-10642926. We have measured the activity of two platelet 5HT-associated proteins: 5HT transporter ( 5HTT) and monoamine oxidase B ( MAOB), and indirectly studied the activity of 5HT(2A) receptor (5HT(2A)r) in 15 hyperserotonemic (HS) and 17 normoserotonemic (NS) autistic subjects, and 15 healthy controls (C). Paper-13721163. All synthesized derivatives were tested for their affinities for the dopamine transporter ( DAT), serotonin ( 5-HT) transporter ( SERT), and norepinephrine transporter (NET) in the brain by measuring their potency in inhibiting the uptake of [(3)H]DA, [(3)H]5-HT, and [(3)H]NE, respectively. Paper-12771896. Monoamine transporter inhibition by Delta3,2-hydroxybakuchiol was more selective for the dopamine transporter ( DAT) (IC50=0.58+/-0.1 microM) and norepinephrine transporter (NET) (IC50=0.69+/-0.12 microM) than for the serotonin transporter ( SERT) (IC50=312.02+/-56.69 microM). Paper-12784890. Overall our results indicates that the HTR2A, 5-HTT, DRD3 and GABA(A)gamma2 genes are not likely to be a major genetic risk factor for heroin abuse in this population, with the exception of possible association between nasal inhalation and DRD2 promoter - 141DeltaC polymorphism. Paper-9200783. We showed that this transcription factor is exclusively expressed in the midline part of the human brainstem containing raphe nuclei, which also specifically expressed 5-HT transporter ( sert) and tryptophan hydroxylase ( tph), two markers of the 5-HT neurotransmitter system. Paper-10205881. Through active reuptake of serotonin into presynaptic neurons, the serotonin transporter ( 5-HTT) plays an important role in regulating serotonin concentrations in the brain, and it is the site of binding for tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs). Paper-13537893. We investigated the expression and role of the 5-HT transporter ( 5-HTT) and 5-HT1B, 5-HT2A, and 5-HT2B receptors in lungs and isolated PA-SMCs from patients with primary PH (n=14), pulmonary veno-occlusive disease (n=4), or secondary PH (SPH, n=8) and nonpulmonary hypertensive control subjects. Paper-10412742. Highly significant differences in AVPR1a haplotype frequencies ( RS1 and RS3), especially when conditional on both SLC6A4 polymorphisms (HTTLPR and VNTR), were observed between dancers and athletes using the UNPHASED program package (Cocaphase: likelihood ratio test [ LRS] = 89.23, p = 0.000044). Paper-11479782. OBJECTIVE: Functional magnetic resonance imaging was used to assess neural response to uncued unpleasant affective pictures in 21 unmedicated patients with MDD compared to 21 matched healthy controls, taking into account genetic influences of the 5-HTT (SCL6A4) high- and low-expression genotype. Paper-13873977. These studies reveal cellular phenotypes associated with naturally occurring human SERT coding variants and suggest that altered transporter regulation by means of PKG/ p38 MAPK- linked pathways may influence risk for disorders attributed to compromised 5-HT signaling. Paper-11047657. Moreover, chronic (48 h) exposure of cells to caffeine (1 microM) stimulated and chronic exposure to xanthohumol and iso-xanthohumol (1 and 0.1 microM, respectively) inhibited (3)H-thiamine uptake, these effects being not mediated through modulation of the expression levels of either hThTr-1 or hSERT mRNA. Paper-12079668. By including individuals varying in their degree of susceptibility to MD, we showed evidence of interactions between 5-HTT and MD susceptibility in baseline cortisol, and between MAOA and MD susceptibility in baseline ACTH measures, indicating a role for these genotypes in stable-state endocrine regulation. Paper-13200921. One candidate SERT-regulatory protein is the SNARE (soluble N-ethylmaleimide-sensitive factor-attachment protein receptor) protein, syntaxin 1A (Syn1A), which has recently been implicated in the regulation of ion channels as well as the SERT-related gamma-aminobutyric acid- and glycine-transporters. Paper-8926261. Furthermore, during a 3-week moderate endurance training of sedentary males basaline values of Bmax of 5-HT transporters ( 5-HTT) and 5-HT2A receptors (5-HT(2A)R) on isolated platelet membranes increased while plasma prolactin ( PRL) concentrations decreased as well as mood and physical efficiency improved. Paper-8829672. The promoter polymorphism of the serotonin transporter gene ( HTT, locus SLC6A4) is of special interest in autism given the well-replicated platelet hyperserotonemia of autism, treatment effects of serotonin reuptake inhibitors, and the role of serotonin in limbic functioning and neurodevelopment. Paper-9004216. Cotransfection of HEK-293 cells with SERT and a constitutively active form of MAP kinase kinase 3b(E) [MKK3b(E)] increased 5-HT transport, and RNA interference targeted to p38 MAPK inhibited 5-HT uptake, confirming the involvement of active p38 MAPK in SERT expression. Paper-10759515. This study examined the effects of chronic, escalating doses of D-AMPH followed by 24 h of withdrawal on the expression of prodynorphin ( PD) and c-fos mRNA in limbic regions of the brain, caudate putamen (CPu), and brainstem and SERT mRNA expression in the dorsal raphe nucleus (DRN). Paper-13593738. Competition binding in cells stably expressing the transfected human DAT and serotonin transporter ( SERT) labeled by [(3)H]WIN 35428 and [(3)H]citalopram, respectively, demonstrated the following order of DAT affinity (K(i) in nM): GBR 12909 (0.36) > CIT (0.48) > (S)-FIPCT (0.67) >> (R)-FIPCT (3.2). Paper-2130213. In the same animals, tryptophan hydroxylase (TPH)-IR axon density was comparably reduced, indicating that serotonergic deficits after substituted amphetamines differ from those in SERT-null animals, which have normal TPH levels but, in the absence of SERT, develop apparent neuroadaptive changes in 5-HT metabolism. Paper-12318532. Among these, the finding of an association between PPH and the L-allelic variant of the serotonin transporter ( 5-HTT) gene indicates that 5-HTT, which controls smooth muscle hyperplasia, probably contributes to susceptibility to PPH or is an important modifier of the PPH phenotype. Paper-9595016. For the eight genes for which the same variant has been studied in three or more case-control or family-based studies, seven show statistically significant evidence of association with ADHD on the basis of the pooled odds ratio across studies: DRD4, DRD5, DAT, DBH, 5-HTT, HTR1B, and SNAP-25. Paper-10796019. Very few or no significant associations were seen for the DRD2/ ANKK1 TaqIA polymorphism, the serotonin transporter promoter VNTR or 5HTTLPR ( SLC6A4), the dopamine transporter 3' VNTR ( SLC6A3), and the mu opioid receptor A118G single nucleotide polymorphism (mu opioid receptor polymorphism 1). Paper-12965353. The P values of odds ratios to habitual smoking for CYP17A1, ESR1, EPHX1, GSTT2, ALDH2, NOS2A, OGG1, and SLC6A4 and those of odds ratios to habitual drinking for CYP1B1, ESR1, HSD17B3, GSTM3, COMT, ADH1C, ALDH2, NOS3, and NUDT1 were under 0.05. Paper-11282139. Genotypes and allelic frequencies of TPH2, 5-HTTLPR, the 5-HTT ( SLC6A4) intron 2 variable-number tandem repeat ( VNTR) region, and the MAOA VNTR region were determined in brain-stem samples of 20 "genuine" SIDS cases and compared with results obtained from 150 healthy controls. Paper-12820474. Two novel radioligands, N,N-dimethyl-2-(2-amino-4-methoxyphenylthio) b enzylamine ( DAPP) and (N,N-dimethyl-2-(2-amino-4-cyanophenylthio) benzylamine (D ASB), were radiolabeled with carbon-11 and evaluated as in vivo probes of the serotonin transporter ( SERT) using positron emission tomography (PET). Paper-8744236. Our data suggest that a decreased expression of the gene encoding the 5-HTT transporter, due to "S" promoter polymorphism, may be associated with an increased availability to experiment illegal drugs among adolescents, particularly in the subjects with more consistent aggressiveness, NS temperament and learning disabilities. Paper-11501581. Examining 5-HTT gene promoter polymorphism, heterozygous individuals (l/s) and individuals with 44-bp deletion (s/s) scored significantly lower in the HA1 subdimension (anticipatory worry and pessimism vs. uninhibited optimism; 4.3 +/- 2.3 vs. 5.5 +/- 2.6) in comparison with individuals without deletion (l/l); p = 0.021. Paper-8838340. Furthermore, three potential candidate genes that might be involved in endometriosis related pain were identified: tyrosine kinase receptor B (TRkB) in endometriosis epithelial cells, and serotonin transporter ( 5HTT) and mu opioid receptor ( MOR) in endometriosis stromal cells were all upregulated. Paper-10867929. Measures of 5-HT function included whole blood 5-HT ( WBS) concentrations, cerebrospinal fluid (CSF) concentrations of the 5-HT metabolite 5-hydroxyindoleacetic acid ( 5-HIAA) and brain 5-HT transporter ( SERT) availability obtained using positron emission tomography (PET). Paper-13523769. In this study, nine polymorphisms in four serotonin receptor genes ( HTR1B, HTR2A, HTR5A and HTR6) and the serotonin transporter gene ( SLC6A4) were analysed to investigate their influence on antidepressant response in a well-characterized unipolar depressive population (n=166) following a protocolized treatment regimen. Paper-12773123. Methods: Regional brain 5- HTT BP(P) was measured using positron emission tomography (PET) with [(11)C]McN 5652 and a metabolite-corrected arterial input function in 43 healthy volunteers and 23 subjects in a major depressive episode, ten of whom reported a history of sexual and/or physical abuse before age 15, and 13 of whom did not. Paper-13766643. SERT expression in the three different inducible stable mammalian cell lines was induced either by a decrease in temperature ( cell line pCytTS-SERT), the addition of tetracycline to the growth medium ( cell line T-REx-SERT) or by adding DMSO which caused the cells to differentiate ( cell line MEL- SERT). Paper-9678806. We tested four genes [ phenylalanine hydroxylase ( PAH), the serotonin transporter ( SLC6A4), monoamine oxidase B ( MAOB), and the gamma-aminobutyric acid A receptor beta-3 subunit ( GABRB3)] for their impact on five schizophrenia symptom factors: delusions, hallucinations, mania, depression, and negative symptoms. Paper-13691070. Across 118 meta-analyses, a total of 24 genetic variants in 16 different genes ( APOE, COMT, DAO, DRD1, DRD2, DRD4, DTNBP1, GABRB2, GRIN2B, HP, IL1B, MTHFR, PLXNA2, SLC6A4, TP53 and TPH1) showed nominally significant effects with average summary odds ratios of approximately 1.23. Paper-12854626. In the present study, we investigated a polymorphism in the promoter region of the serotonin transporter ( SLC6A4) and two polymorphisms (-1438 A > G and His452Tyr) in the serotonin 5- HTR2A receptor gene using family based association analyses in a sample of 243 Brazilian ADHD children and adolescents and their parents. Paper-12385119. Further, significant heterogeneity was observed for the associations between ADHD and DAT1, DRD4, DRD5, DBH, ADRA2A, 5HTT, TPH2, MAOA, and SNAP25, suggesting that future studies should explore potential moderators of these associations (e.g., ADHD subtype diagnoses, gender, exposure to environmental risk factors). Paper-13783758. In a general population sample of 607 Italian preadolescents, we examined the independent and joint effects of SES and the dopamine receptor D4 ( DRD4) and serotonin transporter linked promoter region ( 5-HTTLPR) polymorphisms upon rule-breaking and aggressive behaviors measured with the Child Behavior CheckList/6-18. Paper-12572437. Using in situ hybridization, we examined the mRNA expression of 5-hydroxytryptamine transporter ( 5-HTT) and 5-hydroxytryptamine 1A receptor ( 5-HT1AR) in 3 crucial regions in addiction, namely the ventral tegmental area (VTA), the nucleus accumbens ( NAc), and the medial prefrontal cortex (mPFC), during the dependence and withdrawal. Paper-13009074. Competition binding in cells stably expressing the transfected human SERT, dopamine transporter ( DAT), and norepinephrine transporter (NET) using [(3)H]citalopram, [(3)H]WIN 35,428, and [(3)H]nisoxetine, respectively, demonstrated the following order of SERT affinity (K(i) in nM): ZIENT (0.05) > nor-CIT (0.12) >> EIENT (1.15) > fluvoxamine (1.46). Paper-9843960. Genetic studies of human biogenic amine transporter genes, including the dopamine transporter ( hDAT; SLC6A3), the serotonin transporter ( hSERT; SLC6A4), and the norepinephrine transporter ( hNET; SLC6A2) have provided insight into how genomic variations in these transporter genes influence pharmacology and brain physiology. Paper-12112333. The mRNA expression levels of CNT1, CNT2, apical sodium-dependent bile acid transporter (ABST), serotonin transporter ( SERT), PEPT1, and OCTN2 exhibit marked differences between different regions of the intestine: the first five are predominantly expressed in the small intestine, whereas OCTN2 exhibits strongest expression in the colon. Paper-12469774. We analyzed five genes, derived from pharmacological or translational mouse models, in a new case-control study of PD and SAD in European Americans: (1) the serotonin transporter ( SLC6A4), (2) the serotonin receptor 1A, (3) catechol-O-methyltransferase, (4) a regulator of g-protein signaling and (5) the gastrin-releasing peptide receptor. Paper-13529401. METHOD: The authors assessed dopamine transporter genotype at the SLC6A3 3' variable number of tandem repeats ( VNTR) polymorphism and serotonin transporter genotype at the SLC6A4 promotor VNTR polymorphism in 30 healthy subjects who also underwent single photon emission computed tomography with [(123)I]beta-CIT. Paper-8663853. To address this issue, we looked for associations between markers in neurotransmitter genes (the serotonin transporter gene, 5-HTT; the serotonin receptor 2A, 5HT2A; the dopamine D2 receptor gene, DRD2; and the dopamine D4 receptor gene, DRD4) and the six styles of love as conceptualized by Lee (Eros, Ludus, Storge, Pragma, Mania and Agape). Paper-12652996. Using quantitative in situ hybridization, we measured messenger RNA (mRNA) levels of tryptophan hydroxylase ( TPH), 5-HT transporter ( 5-HTT), 5-HT1A and 5-HT1B autoreceptors, dopamine receptor-D2 ( DR-D2) autoreceptors and postsynaptic receptors, and dopamine receptor-D1 ( DR-D1) postsynaptic receptors, in discrete brain regions of HCR and LCR. Paper-12241720. In our sample of 814 patients comprising 114 with schizophrenia, 416 with bipolar affective disorder and 284 with unipolar affective disorder, we studied interactions between the tryptophan hydroxylase ( TPH), the serotonin transporter ( 5-HTTLPR), and the dopamine receptor ( DRD4) genes in relation to five major psychiatric symptomatology scores. Paper-10772653. These synonyms are used for gene SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4): Solute carrier family 6 member 4, Sodium-dependent serotonin transporter, SERT, OCD1, HTT, hSERT, 5HT transporter, 5-HTTLPR, 5-HTT, 5HTT. These accession numbers are used for gene SLC6A4: CAA50029 (NCBI_GENBANK__AC), B3VRU0 (UNIPROT__AC), B2R7Y7 (UNIPROT__AC), AAH69484 (NCBI_GENBANK__AC). SLC6A4 is a homologue of slc6a4a (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4A) from Danio rerio. SLC6A4 is a homologue of SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4) from Bos taurus. SLC6A4 is a homologue of SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4) from Pan troglodytes. SLC6A4 is a homologue of SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4) from Gallus gallus. SLC6A4 is a homologue of SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4) from Canis lupus familiaris. SLC6A4 is a homologue of Slc6a4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4) from Mus musculus. SLC6A4 is a homologue of Slc6a4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4) from Rattus norvegicus. Important links ! iHOP - Information Hyperlinked over Proteins . Concept & Implementation by Robert Hoffmann.