The most recent information on SLC6A4 is here. Click here for the function of SLC6A4. Edit this page in Wiki Genes - SLC6A4 or see Wiki Gene. MAOA, COMT and 5-HTT polymorphisms were analyzed. Paper-13977425. Genotyping is done for the DAT, DRD4, and 5-HTT genes. Paper-14157769. In girls, a significant DRD4 x 5-HTT interaction was detected. Paper-12276957. ITGB3 shows genetic and expression interaction with SLC6A4. Paper-12139528. The genotyping of the DRD2, DRD4, GABRB3, 5-HTTLPR was carried out. Paper-14298011. 5-HTT gene polymorphic variants have been associated with both MDD and SCZ. Paper-14390081. CONCLUSIONS: These results support an involvement of 5-HTTLPR in the etiology of MDD. Paper-10787992. Together, these results indicate a distinct role of p38 MAPK in SERT regulation. Paper-10759515. Interaction analysis between 5-HTTLPR and TNFA -238/-308 polymorphisms in schizophrenia. Paper-14707429. We observed neither main effects nor interactions with CYP2A6, DAT, and SLC6A4 genes. Paper-12686654. We thus show for the first time that the cytokine TNF-alpha modulates 5-HTT function. Paper-1643999. LEPR, ADBR3, IRS-1 and 5-HTT genes polymorphisms do not associate with obesity. Paper-13159144. SERT availability decreased by a mean 36.5%, whereas DAT availability increased by about 40%. Paper-11215042. The frequencies of COMT Val158Met, 5-HTTLPR, and TPH IVS7+218C>A polymorphisms were determined. Paper-9153578. We also examine whether ITGB3 might interact with SLC6A4 to contribute to autism susceptibility. Paper-12139528. Five genes showed significant adjusted effects ( HTR2A, TPH1, HTR5A, SLC6A4 and HTR1A). Paper-14112342. Social adversity, the serotonin transporter ( 5-HTTLPR) polymorphism and major depressive disorder. Paper-11331369. We demonstrate that one of the mitogen-activated protein kinases (MAPKs), p38 MAPK, regulates SERT. Paper-10759515. For protective allele associations, the ORs are between 0.842 and 0.886, for DAO, IL1B, and SLC6A4. Paper-12982428. 5-HTT, DRD4, and COMT genes polymorphisms are not associated with fear during childbirth in Korea. Paper-14547898. Independent genetic effects of 5-HTTLPR SCL6A4 and OXTR rs53576 on observed maternal sensitivity were found. Paper-14338638. The meta-analysis included data on the DRD2, DAT, 5HTT, and CYP2A6 genes and smoking behavior. Paper-10906688. Shortest duration of looking was associated with the L- DRD4 and s/ s 5-HTTLPR genotypes. Paper-8901298. Polymorphisms in SLC6A4, PAH, GABRB3, and MAOB and modification of psychotic disorder features. Paper-13691070. Gene variants that affect COMT, MAOA and 5HTT activity have previously been linked to antisocial behaviour. Paper-14088295. Family-based association study of 5-HTTLPR, TPH, MAO-A, and DRD4 polymorphisms in mood disorders. Paper-9466551. The association of SERT with Rab4-GTP depends on: (i) 5HT modification and (ii) the GTP-binding ability of Rab4. Paper-14386990. Family-based and case-control study of DRD2, DAT, 5HTT, COMT genes polymorphisms in alcohol dependence. Paper-12305556. Other variants at the AGT, ACE, 5-HT2A and 5-HTT did not contribute to the risk of cardiac hypertrophy. Paper-15285003. GST-pulldown assays confirmed the physical interaction between SCAMP2 and the N-terminal domain of SERT. Paper-12242696. Furthermore, we mapped the Rab4- SERT association domain to amino acids 616-624 in the cytoplasmic tail of SERT. Paper-14386990. CONCLUSION: "s" allele variant in the intron 2 of SERT gene could be associated with susceptibility to MDD. Paper-12133511. We found the association between DRD1, DRD4, COMT and SERT genes polymorphisms and the performance on WCST. Paper-15250755. Functional SLITRK1 var321, varCDfs and SLC6A4 G56A variants and susceptibility to obsessive-compulsive disorder. Paper-12197069. Alterations in expression of p11 and SERT in mucosal biopsy specimens of patients with irritable bowel syndrome. Paper-12435341. BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism. Paper-14278241. ADH1B*1, ADH1C*2, DRD2 (-141C Ins), and 5-HTTLPR were associated with alcoholism in Mexican Americans (p < 0.05). Paper-10610938. Brain-derived neurotrophic factor- 5-HTTLPR gene interactions and environmental modifiers of depression in children. Paper-11307101. Oxytocin receptor ( OXTR) and serotonin transporter ( 5-HTT) genes associated with observed parenting. Paper-14338638. Only three of the candidates-DRD5, 5HTT, and CALCYON-coincided with sites of positive linkage identified by our screen. Paper-9160218. Using murine and human expression data, we observe that ITGB3 and SLC6A4 expression levels are correlated (0.38<r<0.78). Paper-12139528. We have constructed a 1 Mb YAC and PAC contig which harbours both the SLC6A4 and the carboxypeptidase D ( CPD) genes. Paper-2165529. Allelic frequencies of genomic variations for 5HTT, NAT1, NAT2, PON1, PON2, and SOD2 were determined. Paper-12843455. No significant differences in genotype or allele frequencies were found for 5-HTTLPR or MTHFR (p-values > 0.3). Paper-14133218. CONCLUSIONS: Using a prospective design, 5-HTTLPR is associated with MDD incidence during interferon-alpha treatment. Paper-13538512. Our study did not support the involvement of 5-HTTLPR, TPH, MAO-A, or DRD4 polymorphisms in mood disorders. Paper-9466551. No gene by environment (GxE) interactions between the 5-HTTLPR genotype, social adversity, and MDD were observed. Paper-11331369. Refined mapping of the human serotonin transporter ( SLC6A4) gene within 17q11 adjacent to the CPD and NF1 genes. Paper-2165529. No evidences for biased transmissions of both HTR2A -1438 A > G and SLC6A4 polymorphisms to ADHD youths were observed. Paper-12385119. Consistent with these findings, knockout mice lacking integrin beta3 displayed diminished platelet SERT activity. Paper-14302971. Convergent genetic modulation of the endocrine stress response involves polymorphic variations of 5-HTT, COMT and MAOA. Paper-13200921. All subjects were then genotyped for selected polymorphisms at the SLC6A4, HTR7, HTR2A, ITGB3, and TPH1 loci. Paper-12660183. METHODS: Messenger RNA (mRNA) expression of SLC6A4 and p11 was measured in sigmoid and rectal mucosal biopsy specimens. Paper-12435341. In agreement with published meta-analysis our results indicate that 5-HTT associates with SCZ but not with MDD. Paper-14390081. Functional variants of the serotonergic genes 5-HT1A and 5-HTT possibly modulating S100B serum levels were also studied. Paper-14110177. In addition to the significant independent effects, evidence for interaction between SLC6A4 and ITGB3 markers was also found. Paper-13150896. Genotyping was performed for 5-HTTLPR and two single nucleotide polymorphisms ( SNPs) (-1438G/A and 102T/C) of HTR2A. Paper-13137617. Associations between the exploratory assessed 5-HTT, COMT, and DAT polymorphisms and affect-modulated ASR were not found. Paper-14551752. Additionally, moderate association (P<0.05) was observed with 8 tagSNPs on SLC6A3, DBH, DRD4, SLC6A4, and COMT. Paper-13927044. Furthermore a progressive truncation of the C-terminus of SERT was performed to map the vimentin- SERT association domain. Paper-13654445. Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels. Paper-13150896. Blood was drawn from 247 subjects and analyzed for platelet MAO-B activity and polymorphisms in the MAO-A and 5-HTT genes. Paper-14320159. Association study of polymorphisms in LRP1, tau and 5-HTT genes and Alzheimer's disease in a sample of Colombian patients. Paper-12195037. Promoter variants of the cannabinoid receptor 1 gene ( CNR1) in interaction with 5-HTTLPR affect the anxious phenotype. Paper-14157123. The effect of COMT, BDNF, 5-HTT, NRG1 and DTNBP1 genes on hippocampal and lateral ventricular volume in psychosis. Paper-14029703. Neither was there any effect of the BDNF, 5-HTTLPR, NRG1 and DTNBP1 genotypes on these regional brain volumes. Paper-14029703. ADHD and Disruptive Behavior scores - associations with MAO-A and 5-HTT genes and with platelet MAO-B activity in adolescents. Paper-14320159. Some ADHD polymorphisms (in genes DAT1, DRD2, DRD3, DBH, 5-HTT) in case-control study of 100 subjects 6-10 age. Paper-14413119. Genetic correlates of behavioral endophenotypes in Alzheimer disease: role of COMT, 5-HTTLPR and APOE polymorphisms. Paper-12233516. RATIONALE: Serotonin transporter ( 5-HTT) and norepinephrine transporter (NET) are the primary targets of many antidepressants. Paper-13893732. In addition, co-immunoprecipitation experiments showed that SERT and syntaxin 1A form a protein complex in these neurons. Paper-9225740. Neither 5-HTTLPR L/ S nor DAT1 G2319A SNP genotypes nor alleles discriminated alcoholic patients from normal controls. Paper-11328857. Sexually dimorphic effects of four genes ( COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary study. Paper-14340221. A physical interaction between Myc- SERT- calnexin and Myc- SERT- calreticulin was demonstrated by co-immunoprecipitation. Paper-1899977. Incubation of thalamocortical cultures with botulinum toxin C1, which specifically cleaves syntaxin 1A, decreased SERT function. Paper-9225740. Association studies of MAO-A, COMT, and 5-HTT genes polymorphisms in patients with anxiety disorders of the phobic spectrum. Paper-10624525. Significant 5-HTTLPR x CNR1 promoter-promoter interaction was observed using STAI-T ( P = 0.0006) and TEMPS-Anx ( P = 0.0013). Paper-14157123. Taken together, our results suggest that SCAMP2 plays an important role in the regulation of the subcellular distribution of SERT. Paper-12242696. We genotyped 706 individuals for the 5-HTTLPR in the SLC6A4 promoter and 4 SNPs located in the CNR1 promoter region. Paper-14157123. ADH1B*1, ADH1C*2, DRD2 (-141C Ins), and 5-HTTLPR are associated with alcoholism in Mexican American men living in Los Angeles. Paper-10610938. Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth. Paper-15382154. In the present study, using the yeast two-hybrid system, we identified the membrane glycoprotein M6B as a binding partner of SERT. Paper-13526031. Differential effects of 5-HTTLPR and DRD2/ ANKK1 polymorphisms on electrocortical measures of error and feedback processing in children. Paper-13570222. Significant associations were identified for several candidate genes including DAT1, DRD4, DRD5, 5HTT, HTR1B, and SNAP25. Paper-13783758. CONCLUSIONS: Brain serotonin turnover is elevated in unmedicated patients with MDD and is influenced by the 5-HTT genotype. Paper-14330025. Using a yeast one-hybrid screen, we found the transcription factor Y box binding protein 1 (YB-1) interacts with the 5-HTT VNTR. Paper-10442691. We have investigated four ADHD candidate genes ( COMT, SLC6A2, MAOA, SLC6A4) for which there is evidence of sexually dimorphic effects. Paper-14340221. Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features. Paper-13982907. In another study, interaction of 5-HTTLPR with the cannabinoid receptor 1 gene promoter was significantly associated with anxious phenotype. Paper-15282631. OPRM1 (AA>AG or GG) was associated with smoking reward, but SLC6A4 variable number tandem repeat was unrelated to any of these measures. Paper-12965354. The correlation of the SERT promoter polymorphism with age at diagnosis in FPAH suggests a possible relationship between the SERT and BMPR2. Paper-11313406. The translocation of SERT between these compartments is correlated with changes in the interaction with the LIM domain adaptor protein Hic-5. Paper-12183934. We investigated whether the effects of IFN-alpha on the functions of 5-HTT were related to mitogen-activated protein kinase ( MAPK). Paper-12978381. We found that the variants of 5-HTTLPR interacted with the DAT1 gene polymorphism to influence the HA and RD temperament subscales of TCI. Paper-12133134. RESULTS: There was a significant three-way interaction between BDNF genotype, 5-HTTLPR, and maltreatment history in predicting depression. Paper-11307101. Panic disorder and serotonergic genes ( SLC6A4, HTR1A and HTR2A): Association and interaction with childhood trauma and parenting. Paper-15422926. HTR2A T102C, HTR2C Cys23Ser and 5-HTTLPR interaction terms associated with early onset component under dominant, recessive and additive model. Paper-15203190. No association between lithium full responders and the DRD1, DRD2, DRD3, DAT1, 5-HTTLPR and HTR2A genes in a Sardinian sample. Paper-13977469. Likewise, the >5% group had the highest percentage of athletes with the combined SS 5-HTT and/or +9/+9 BDKRB2 genotypes (chi(2)=7.4, P=0.007). Paper-12251798. An investigation of associations between alcohol use disorder and polymorphisms on ALDH2, BDNF, 5-HTTLPR, and MTHFR genes in older Korean men. Paper-14133218. In conclusion, we detected a role of SLC6A4 in mood changes after stressful events, and revealed new putative associations involving DDC and PRKCB. Paper-15160505. CONCLUSIONS: These data do not suggest independent or interactive effects of the TH Val(81)Met, the 5-HTTLPR/rs25531, or the STin2 polymorphisms in BPD. Paper-14245385. 2) The risk of ADHD is significantly increased at homozygotes for risk alleles in genes DRD2 (O.R.=54,8), 5-HTT (O.R.=6,7) and DAT1 (O.R.=6,6). Paper-14413119. We also detected significant interactions between 5-HT2C and TPH2 (p=0.001), and among 5-HT2C, 5-HTT, MAOA and TPH2 (p=0.001) in BPD. Paper-13578352. This finding provides an explanation for the role of the C terminus in the localization and trafficking of SERT via Rab4 in a plasma 5HT-dependent manner. Paper-14386990. YB-1 and CTCF differentially regulate the 5-HTT polymorphic intron 2 enhancer which predisposes to a variety of neurological disorders. Paper-10442691. The analyses of 5-HT2A receptor gene, 5 HTT gene, and COMT gene polymorphisms were performed using polymerase chain reaction ( PCR) technique. Paper-10019581. BACKGROUND/AIMS: The norepinephrine transporter (NET) and serotonin transporter ( 5-HTT) genes constitute promising candidate genes in major depression. Paper-15283939. Moreover, genetic variation in ITGB3 is associated with expression of both ITGB3 (P=0.012) and SLC6A4 (P=0.008) in unrelated CEPH individuals. Paper-12139528. These genes are the catechol-O-methyltransferase gene ( COMT Val158Met) and the regulatory region ( 5-HTTLPR) of the serotonin transporter gene. Paper-13132305. OBJECTIVE: The aim of this study is to evaluate the association between HTR1A, HTR2A and the 5-HTTLPR in panic disorder (PD) patients and controls. Paper-15422926. Neither polymorphisms were associated with symptoms of fatigue ( IL-6: F = 1.2, d.f. = 430, P = 0.2; 5-HTT: F = 0.5, d.f. = 430, P = 0.5). Paper-13077074. 5-HTTLPR genotype was significantly associated with dopaminergic sensitivity ( P = 0.004) explaining 9.2% of the variance of GH response. Paper-14658737. Further bivariate modeling revealed that approximately 10% of the correlation between Beck Depression Inventory and IL-6 could be explained by the SLC6A4 gene. Paper-14621710. Biotinylation studies showed reduced SERT proteins in the plasma membrane of synaptosomes after p38 MAPK inhibition and PKC activation. Paper-10759515. Cathecol-O-methyltransferase ( COMT), serotonin gene-linked promoter region ( 5-HTTLPR), and Apolipoprotein E (ApoE) genotypes were performed. Paper-11807688. CONCLUSIONS: Inconsistent 5-HTTLPR GxE findings to date may be partly attributable to unmeasured epistatic effects between 5-HTTLPR and COMT val158met. Paper-15334610. These findings suggest that the variants of 5-HTTLPR interacted with the DAT1 gene polymorphism to influence the HA and RD temperament subscales of TCI. Paper-12133134. METHOD: Within our study there were selected the genes of dopaminergic ( DRD2, DRD3, DAT1), noradrenergic ( DBH) and serotoninergic ( 5-HTT) systems. Paper-14413119. Genes controlling adrenergic and serotonergic mechanisms ( ADRA2A, GNB3, and SLC6A4) affect gastric emptying (GE), volume ( GV), and satiation. Paper-14092377. No association between FD and the genotype of the insertion/deletion polymorphism in the promoter of SERT (SERT-P) or HTR3A C178T polymorphism was observed. Paper-12836609. The power of sample size and homogenous sampling: association between the 5-HTTLPR serotonin transporter polymorphism and major depressive disorder. Paper-10787992. In this study, we investigated the association of the polymorphism of the DRD2, Dopamine D4 receptor gene ( DRD4), GABRB3, 5-HTTLPR with the COAs. Paper-14298011. Our objective was to examine whether the effects of child abuse are moderated by gene x gene (G x G) interactions between CRHR1 and 5-HTTLPR polymorphisms. Paper-14681656. The association of the dopamine D4 receptor gene ( DRD4) and the serotonin transporter promoter gene ( 5-HTTLPR) with temperament in 12-month-old infants. Paper-8901298. With the stratification of DRD2 TaqI A1(+) allele, high NS of ANX/DEP ALC existed only in carriers of 5-HTTLPR S/ S genotype (p=0.001). Paper-13413395. Of these, 41 studies investigated 45 different 5-HT receptor variants and 45 studies investigated at least one of two commonly studied 5-HTT polymorphisms in MDD. Paper-9921213. In conclusion, the DRD4 genotypes might influence decision-making performance differently according to the background genotypes of 5-HTTLPR. Paper-13977419. The effect of previously described " TGC" haplotype in the alternative promoter of CNR1 depended both on the conventional promoter polymorphism and the 5-HTTLPR. Paper-14157123. In the present report, the interaction of syntaxin 1A with endogenous serotonin transporters ( SERT) expressed in developing thalamocortical neurons is examined. Paper-9225740. CONCLUSIONS: Genetic vulnerability involving the SLC6A4 gene is significantly associated with both increased depressive symptoms and elevated IL-6 plasma levels. Paper-14621710. The purpose of the present study was to investigate the role of the serotonin transporter ( 5-HTT) and serotonin 5-HT1B and 5-HT2A receptor genes in OCD. Paper-11345251. In synaptosomes, PKC activation but not p38 MAPK inhibition resulted in SERT redistribution from cholesterolrich lipid raft fractions to nonlipid raft fractions. Paper-10759515. CONCLUSIONS: The BDNF Met allele may protect S/L(G) 5-HTTLPR homozygotes from increased dysfunctional thinking following a sad mood provocation. Paper-15188843. All patients were genotyped for functional variations in the 5-HT(1A) receptor ( HTR1A), 5-HT transporter ( SLC6A4, 5-HTT), and tryptophan hydoxylase-2 ( TPH2). Paper-13210845. It could be concluded: 1) the risk of ADHD is significantly increased in the presence of one risk allele in genes DRD2 (O.R.=7,5), 5-HTT (O.R.=2,7) and DAT1 (O.R.=1,6). Paper-14413119. CONCLUSIONS: An association between polymorphisms of ACE, AGT, ATR1 and SERT gene, and predisposition to VVS was not proven by the present study (Tab. 2, Ref. 22). Paper-13747103. Gene expression studies of SOD, GPx, 5-HT(2A) and 5-HTT in cerebellum showed a significant down regulation (p<0.001) in diabetic rats compared to control. Paper-15076114. 5-HTT and TPH2 variations did not contribute significantly to the prediction of interferon- induced depression by HTR1A (sensitivity, 35.9%; specificity, 84.0%). Paper-13210845. A fourth possible explanation might be SLC6A4 x BDNF interactions, which prompted us to investigate combined genotypes of BDNF V66M with the three SLC6A4 loci. Paper-12609707. CONCLUSIONS: Overall, the examination of genetic variants at the HTR1B, HTR2A, and SLC6A4 loci indicated no association between the selected polymorphisms and COMD. Paper-14374563. In the present study we investigated the influence of interleukin-4 ( IL-4), which acts as an anti-inflammatory cytokine in the central nervous system, on the 5-HTT. Paper-8683601. In addition, several researchers reported that the COAs might be associated with the GABA A receptor beta3 subunit gene ( GABRB3) and serotonin transporter gene ( 5-HTTLPR). Paper-14298011. In the final model, the only significant variables selected for smoking were OGG1, SLC6A4, EPHX1, ESR1, and CYP17A1, and for drinking, ALDH2 and NUDT1. Paper-11282139. Association study of the INPP1, 5HTT, BDNF, AP-2beta and GSK-3beta GENE variants and restrospectively scored response to lithium prophylaxis in bipolar disorder. Paper-12062094. We used an association study examining G x G x E interactions of CRHR1 and 5-HTTLPR polymorphisms and measures of child abuse on adult depressive symptomatology. Paper-14681656. We performed 5-HTT and 5-HT1A binding, 5-HTT mRNA in situ and tryptophan hydroxylase ( TPH) immunoautoradiography on depressed suicides and controls brainstem sections. Paper-12219035. Associations of SERT with Hic-5 are evident in brain synaptosomes, suggesting the existence of parallel mechanisms operating to regulate SERT at serotonergic synapses. Paper-12183934. Since both 5-HT and TNF-alpha are elevated at sites of inflammation, TNF-alpha may act to renormalize 5-HT levels by way of its effect on the 5-HTT. Paper-1643999. DNA from buccal smears successfully obtained from 98 children was genotyped by polymerase chain reaction methods for the 5-HTTLPR, DRD4, COMT, and MAO(A) polymorphisms. Paper-9664576. Functional polymorphisms in the promoter region of the IL-6 gene (rs1800795) and serotonin transporter gene ( 5-HTTLPR) have been identified as regulating these systems. Paper-13077074. The co-expression of SERT with M6B results in a significant decrease in SERT-mediated serotonin uptake caused by a down-regulation of SERT surface expression. Paper-13526031. Although some heterogeneity was present across studies, our finding suggests that 5-HTTLPR, STin2, HTR1A, HTR2A, TPH1 and BDNF may modulate antidepressant response. Paper-14517845. Five candidate genes, the receptors DRD2, DRD3, HTR2A and GABA(A)gamma2, and the serotonin transporter ( 5-HTT) were analyzed for association with heroin abuse. Paper-9200783. There were no significant differences in the genotype frequencies of the DRD2, ALDH2, 5-HTTLPR, and COMT polymorphisms between alcoholics with and without ADHD. Paper-12127286. METHODS: 5-HTT binding was quantified using positron emission tomography (PET) with [(11)C]McN5652 in 19 currently depressed subjects with MDD and 41 healthy controls. Paper-13040237. Responders and nonresponders were stratified according to 5-HTT, 5-HT1B, and 5-HT2A genotypes and differentiated in paroxetine-or venlafaxine-treated groups. Paper-13242774. In endogenous and heterologous expression systems, our proteomic and biochemical analysis demonstrated that an intermediate filament, vimentin, binds to the C-terminus of SERT. Paper-13654445. SERT is the first member of the neurotransmitter transporter family whose folding has been shown to be assisted by the molecular chaperones calnexin, calreticulin, and BiP. Paper-1899977. In conclusion, our studydoes not provide evidence that the 5HTT, 5-HT1A, 5HT1B,5HT2A and 5HT6 gene polymorphisms play a role in the genetic predisposition to MOH. Paper-14216691. Weak, though significant, association coefficients obtained with HTT and LEPR loci indicate that the genotype numbers at these loci may depend on BMI status to some extent. Paper-13159144. In addition, SERT was found to form a complex with SCAMP2 as demonstrated by co-immunoprecipitation from a heterologous expression system and from rat brain homogenate. Paper-12242696. Conversely, following 5HT stimulation, the association between vimentin- SERT is enhanced which changes the cellular distribution of SERT on an altered vimentin network. Paper-13654445. In addition to the previously reported contribution of SLC6A4, we found significant associations of ITGB3 haplotypes with serotonin level distribution ( P = 0.0163). Paper-13150896. Markers within, or close to, each of the serotonergic genes 5HTT, HTR2A, HTR2C, MAOA ( monoamine oxidase type A) and tryptophan hydroxylase ( TPH) were genotyped. Paper-10624365. We also examined whether measures of impulsivity, hostility and sensation seeking influenced the relationship between the 5-HTTLPR polymorphism and PRL response to m-CPP in this sample. Paper-12303238. Polymorphisms in genes encoding the serotonin receptor type three A subunit ( HTR3A), the serotonin transporter ( SERT) and the G-protein beta3 subunit ( GNB3) were analysed. Paper-12836609. The aim of this study was to investigate possible associations of functional polymorphisms within the IL-6, 5-HTT, and MAO-A genes with endurance performance of Ironman triathletes. Paper-14584897. Thus, the aim of our study was to analyze the interaction of the promoter regions of the serotonin transporter ( SLC6A4) and cannabinoid receptor 1 ( CNR1) genes on anxiety. Paper-14157123. To study how SLC6A4 genetic vulnerability influences the relationship between depressive symptoms and IL-6, bivariate models were constructed using structural equation modeling. Paper-14621710. Logistic regression analysis showed a lack of interaction between the TH Val(81)Met and the 5-HTTLPR/rs25531 as well as between the TH Val(81)Met and the STin2 polymorphism. Paper-14245385. Specifically, there was a significantly lower rate of CCK-4- induced panic attacks in female subjects who had MAO-A longer alleles or 5-HTTLPR short allele gene variants. Paper-10643526. Although both temperament and attachment behavior were affected by the DRD4 repeat polymorphism, the effect on temperament measures was modified by the infants' 5-HTTLPR genotype. Paper-9660788. While DCT is in good overall agreement with GAT and HTT, there is some systematic deviation at different pressure ranges in normal, ocular hypertension, and glaucoma populations. Paper-12515018. A single injection of dexamethasone did not affect mRNA expressions of TPH, MAO-A and 5-HTT genes, but repeated dexamethasone increased them in the dorsal raphe nucleus. Paper-12721094. Furthermore, we find, using confocal microscopy, that M6B co-localizes with SERT when transiently expressed in HEK-MSR-293 cells and when endogenously expressed in RN46A cells. Paper-13526031. The role of clinical variables, neuropsychological performance and SLC6A4 and COMT gene polymorphisms on the prediction of early response to fluoxetine in major depressive disorder. Paper-15497992. DNA samples were prepared to detect polymorphisms of 5HTT, aldehyde dehydrogenase 2 ( ALDH2), D2 dopamine receptor ( DRD2), and cytochrome p450 2A6 ( CYP2A6) genes. Paper-14108760. Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans. Paper-14579735. The goal of this study was to elucidate whether the 5-HTTLPR polymorphism is associated with the mirtazapine antidepressant response in subjects with major depressive disorder ( MDD). Paper-13355087. CONCLUSIONS: These results support the hypothesis that GNB3, HTR2A, and SLC6A4 may play a role in the outcome of short-term antidepressant treatment for MDD in an interactive manner. Paper-13977403. Using the yeast two-hybrid approach we screened a human brain cDNA library and identified secretory carrier membrane protein 2 ( SCAMP2) as a novel SERT-interacting protein. Paper-12242696. After immunization with MOGp 35-55, or with rat MBP, the disease courses of the 5-HTT knockout mice were attenuated as compared to wildtype control mice. Paper-11101583. CONCLUSION: Our findings indicated that 5-HT2A receptor gene, 5 HTT gene, and COMT gene polymorphisms were similar in schizophrenia with non-TD, schizophrenia with TD, and healthy controls. Paper-10019581. A multivariate analysis using a mixed-effects model and including age, sex and predominant ethnicity as covariates was applied to the analyses of 5HTT LPR and DRD4 length polymorphism data. Paper-9908568. However, infants with the 7-repeat DRD4 allele and homozygous for the short form of 5-HTTLPR (7(+), s/ s) showed more anxiety and resistance to the stranger's initiation of interaction. Paper-9660788. HTR2A T102C, HTR2C Cys23Ser, SLC6A4 5-HTTLPR and rs25531 polymorphisms were genotyped in 230 BPD patients and inserted as covariates in a mixture regression model of age at onset (AAO). Paper-15203190. In this report we test for association with genes coding brain-derived neurotrophic factor ( BDNF), the serotonin transporter ( SLC6A4), and catechol-O-methyltransferase ( COMT). Paper-13612237. These markers of satiation were compared for 38 genetic variants in ADRA2A, ADR2C, ADRB3, uncoupling protein (UCP)-2 and -3, GNB3, FTO, and SLC6A4 using a recessive model of inheritance. Paper-14092377. Confirmed association has been reported for several candidate genes, including DAT1, DRD4, SNAP-25, DRD5, 5HTT, HTR1B, and DBH; however, these confer relatively small risk. Paper-12566984. Un-medicated subjects with remitted MDD and healthy controls were genotyped for the long (l) and short (s) alleles of the 5-HTTLPR polymorphism and categorized into one of three genotypes. Paper-14334235. We found that the 5-HTTLPR S allele interacted with CRHR1 haplotypes and child abuse to predict current depressive symptoms ( N = 856, P = 0.016). Paper-14681656. The purpose of the present study was to determine whether polymorphisms of the serotonin transporter ( 5-HTT), 5-HT1B, and 5-HT2A receptor genes affect the efficacy of SRI treatment in OCD. Paper-13242774. Haplotypes at SLC6A4 and individual genotypes of polymorphisms at SLC6A4, HTR7, HTR2A, ITGB3, and TPH1 showed no significant association with whole blood 5-HT. Paper-12660183. Infants with at least one copy of both the 7-repeat DRD4 allele and the long variant of 5-HTTLPR (7(+), l/l&l/ s) responded with significantly less anxiety than infants with other genotypes. Paper-9660788. No significant differences of the allelic distribution of genetic polymorphisms in the genes for 5HTT, NAT1, NAT2, PON1, PON2, and SOD2 were found between cases and controls. Paper-12843455. Two specific meta-analyses were carried out, pooling studies investigating the 5-HT2A 102 T/C and the 5-HTT promoter loci that included, respectively, a total of 1599 and 2539 subjects. Paper-9932275. We genotyped the -1438 A/G polymorphism in the 5-HT2A receptor gene and serotonin transporter linked-polymorphic region ( 5-HTTLPR) in 132 adolescent subjects with AN and in 93 healthy controls. Paper-11330910. The DRD2 TaqIA, exon 8, and promoter -141C ins/del polymorphisms as well as COMT Val158Met, 5HTT 44 bp del in promoter, and DAT 40 bp VNTR polymorphisms were detected by means of PCR. Paper-12725769. Furthermore, SNPs of the genes that contribute to alcohol behavior, DRD3 (rs167770), DRD2 (rs10891556), and SLC6A4 (rs140701), were also associated with an increased risk of breast cancer. Paper-15167418. Further, publicly available human postmortem gene expression data were re-analyzed to elucidate the impact of S100B, 5-HT1A and 5-HTT SNPs on frontal cortex S100B mRNA expression. Paper-14110177. OBJECTIVE: To investigate whether polymorphisms of the serotonin transporter ( 5HTT), serotonin-2a receptor (5HTR2a) and endothelial nitric oxide synthetase ( eNOS) are related to PH in COPD. Paper-14124744. Here we have investigated whether other members of the synuclein family of proteins, gamma-synuclein (gamma-Syn) and beta-synuclein (beta-Syn) can similarly modulate the serotonin transporter ( SERT). Paper-13764183. Pooled data using a fixed-effects model suggested significant associations between the 5HTT LPR, DRD4 c>t, DRD4 length, DRD2 A1/ A2, DRD3 A1/ A2 polymorphisms and personality traits. Paper-9908568. Lower brainstem serotonin and 5-hydroxyindoleacetic acid, fewer prefrontal serotonin transporter ( 5-HTT) sites and more post-synaptic 5-HT1A and 5HT2A receptors were reported in suicide. Paper-12219035. The expression of functional Myc- SERT, as determined by an inhibitor binding assay, was enhanced nearly 3-fold by co-expressing calnexin, and to a lesser degree on co-expression of calreticulin and BiP. Paper-1899977. These results suggest that the caudate and putamen, both of which show high AADC activity, convert 5-HTP to 5-HT at a high rate, and the increased 5-HT competes with [(11)C]DASB for the 5-HTT. Paper-13329083. This downregulation of 5-HTT by fluoxetine and its enhancement by Org 34850 can explain our recent observation that GR antagonists augment the SSRI-induced increase in extracellular 5-HT. Paper-13075656. Past neurobiological and genetic studies suggest that COMT, and SLC6A4 variants may have a greater influence on males and that SLC6A2, and MAOA variants may have a greater influence on females. Paper-14340221. We found that BDNF levels were significantly reduced in the hippocampus and prefrontal cortex of SERT knockout rats, through transcriptional changes that affect different neurotrophin isoforms. Paper-14644636. We tested the hypothesis that variations in serotonergic genes ( TPH2, TPH1, SLC6A4, HTR1A), which influence serotonin availability, affect choice behavior in a probabilistic gambling task. Paper-14278243. Three genes contributed exclusively to mood disorders, one through a main effect ( HTR5A (rs1657268)) and two through gene-environment interactions with CPA ( HTR1A (rs878567) and SLC6A4 (rs3794808)). Paper-14112342. The Multifactor Dimensionality Reduction analysis was used to examine gene-gene interactions in serotonin system, including three other genes ( 5-HTT, 5-HT2A and MAOA) that we previously reported. Paper-13578352. Since tumor necrosis factor alpha ( TNF-alpha) and interleukin-6 are two inflammatory mediators that are central to the initiation of inflammation, we studied the impact of these cytokines on the 5-HTT. Paper-1643999. Co-expression of SERT and SCAMP2 in mammalian cells results in the subcellular redistribution of SERT with a decrease in cell surface SERT and a concomitant reduction in 5-HT uptake activity. Paper-12242696. CONCLUSIONS/SIGNIFICANCE: Based on our findings, we propose that phosphate modification of the SITPET sequence differentially, one at a time exposes the vimentin binding domain on the C-terminus of SERT. Paper-13654445. Therefore, Myc- SERT was co-expressed with the endoplasmic reticulum (ER) molecular chaperones calnexin, calreticulin and immunoglobulin heavy chain binding protein (BiP), and the foldase, ERp57. Paper-1899977. Lastly, the involvement of genes whose products are already the targets for approved drugs, such as SLC6A4, PPARalpha and PPARgamma , in the development of CMS suggests new avenues for CMS pharmacological treatment. Paper-13472860. Finally, the GMDR approach identified a significant gene-gene interaction (P-value=0.025) involving GNB3 and HTR2A, as well as a significant 3-locus model (P-value=0.015) among GNB3, HTR2A, and SLC6A4. Paper-13977403. Genotyping was performed in the 503 patients and in 559 healthy controls to search for polymorphisms of DRD3 p.S9G, DRD2 Taq1A, GRIN2B c.2664C>T, c.366C>G, c.-200T>G, and the promoter region of SLC6A4. Paper-15683590. However, marginal association between subjects with both TNFA -238 A allele ( genotype AA plus AG) and 5-HTTLPR s allele (ss plus sl) and presence of family history was found (p = 0.023; p = 0.026). Paper-14707429. With the exception of the hypoglossal nucleus, where 5-HT1A receptor binding increases while SERT binding remains stable, the medullary 5-HT markers analyzed in the study are essentially "in place" at birth. Paper-10276244. The polymorphisms under investigation were the 5-HTTLPR, the VNTR in intron 2 and the 3'UTR SNP in 5-HTT, the 5- HTR1B variations 861G>C and 102T>C, and the 5- HTR2A variations His452Tyr and 1438G>A. Paper-12468342. Conversely, HEK293 cells engineered to express human SERT and an activated form of integrin beta3 exhibited enhanced SERT function that coincided with elevated SERT surface expression. Paper-14302971. Several SNPs or haplotypes in ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1 and NTRK2 were associated with MDD, and in ABCB1, SLC6A2 and NTRK2 with antidepressant response. Paper-14579735. Drawing on the life course perspective, we predicted a stronger association between the polymorphisms in 5HTT, DAT1, DRD4, DRD2, and MAOA and alcohol consumption in young adulthood than adolescence. Paper-13261688. In population-based sub-analyses, we found significant results in four genes in Asians (ORs between 1.084 and 1.309 for DRD4, GABRB2, PPP3CC, and TP53), and one gene in European (OR of 0.888 for SLC6A4). Paper-12982428. Maternal accounts of temperament and observed response to novelty were investigated for 90 infants, who were independently genotyped for the DRD4 III exon, and for 5-HTT-linked promoter region length polymorphisms. Paper-9660788. CONCLUSION: The association between polymorphisms in serotonergic genes ( SERT and 5-HT2A, 5-HT2C) suggests that these genetic factors can modulate vulnerability to puerperal psychosis in female bipolar participants. Paper-13411549. (b) Participants having specific genotypes such as homozygotes (A1/A1 or A2/ A2) of DRD2 TaqI A, COMTH/COMTH, AG of NET-8, and LL of 5-HTTLPR showed a higher abstinence rate than the other participants. Paper-12693557. The purpose of this study is to investigate the association between four serotonergic polymorphisms (STin2 VNTR and 5-HTTLPR of the SLC6A4 gene, and A-1438G (rs6311) and T102C (rs6313) of the HTR2A gene) and OCD. Paper-14360907. Children with the met allele of the BDNF gene and two short alleles of 5-HTTLPR had the highest depression scores, but the vulnerability associated with these two genotypes was only evident in the maltreated children. Paper-11307101. This study examined the association between two common polymorphisms, the dopamine D4 receptor ( DRD4) gene and the serotonin transporter promoter ( 5-HTTLPR) gene and temperament in 61 infants aged 12 months. Paper-8901298. Gene x environment (G x E) interactions mediating depressive symptoms have been separately identified in the stress-sensitive serotonergic ( 5-HTTLPR) and corticotropin-releasing hormone ( CRHR1) systems. Paper-14681656. Our most intriguing result involved three SNPs in the TPH1 gene and one SNP in the SLC6A4 gene, which show significant single-locus association when response to fluoxetine is compared to nonresponse (P=0.02-0.04). Paper-10642926. We attempted to investigate whether the dopamine D2 receptor ( DRD2) and the serotonin transporter promoter region ( 5-HTTLPR) genes were involved in Novelty Seeking (NS) and Harm Avoidance (HA) of ANX/DEP ALC. Paper-13413395. In contrast, after an excessive training program over four weeks, well-trained endurance athletes showed no change of Bmax of 5-HTT, but a decline of 5-HT(2A)R density and an increase in basal plasma PRL concentration. Paper-8829672. Using confocal microscopy we show that in neuronal cells endogenous SERT co-localizes with SCAMP2 in discrete structures also containing the lipid raft marker flotillin-1 and the SNARE protein syntaxin 1A. Paper-12242696. Although investigating the mechanism by which elevated plasma 5HT level down-regulates the density of SERT molecules on the plasma membrane, we studied Rab4 and SERT in heterologous and platelet expression systems. Paper-14386990. Two proteins that influence the function of serotonin and serotonergic receptors are serotonin transporter protein ( SERT or soluble carrier protein, SLC6A4) and p11 (S-100A10, or calpactin I light chain). Paper-12435341. Functional expression of the unglycosylated SERT mutant, SERT-QQ, was also increased on co-expression of calnexin, suggesting that the interaction between calnexin and SERT is not entirely dictated by the N-glycan. Paper-1899977. The different 5-HT ( serotonin) receptors including the serotonin transporter ( 5-HTT) are candidate genes for affective disorders such as major depressive disorder ( MDD) and bipolar disorder (BD). Paper-9921213. A 19 bp insertion/deletion polymorphism in the dopamine beta-hydroxylase ( DBH) gene, the apolipoprotein ( APOE) epsilon2/epsilon3/epsilon4 variation and 5-HTTLPR in the serotonin transporter gene were genotyped. Paper-12675802. Five other transporters were downregulated; aquaporin 10, SLC6A4, TRPM6, SLC23A1 and SLC30A4, which have specificity for water, serotonin ( 5-HT), magnesium, vitamin C and zinc, respectively. Paper-13321594. Single-nucleotide polymorphisms ( SNPs) in five serotonin receptor genes ( HTR1A, HTR1B, HTR2A, HTR2C and HTR6) and the 5-HT transporter-linked polymorphic region ( 5-HTTLPR) were genotyped. Paper-12154554. Twenty-seven single nucleotide polymorphisms ( SNPs) in the MTR, MTRR, MTHFR, TYMS, ADH1C, ALDH2, GSTP1, NAT1, NAT2, CYP2E1 DRD2, DRD3, and SLC6A4 were genotyped. Paper-15167418. Association of 5-HTTLPR serotonin transporter gene polymorphism and Val66Met brain-derived neurotrophic factor gene polymorphism with auditory N100 evoked potential amplitude in patients with endogenous psychoses. Paper-14509040. Genetic epidemiological studies support an overlap between schizophrenia and bipolar disorder, and COMT, BDNF, 5-HTT, NRG1 and DTNBP1 genes have been implicated in the aetiology of both these disorders. Paper-14029703. Moreover, we observed an additive effect of both genotypes for EPN, with highest neural activity to emotional stimuli in individuals carrying combination of both short variant of 5-HTT and T variant of TPH2. Paper-13171251. The analysed polymorphisms were Arg492Cys ( ADRA1A gene), Ser49Gly and Arg389Gly ( ADRB1), Arg16Gly and Gln27Glu ( ADRB2), 825C/ T ( GNB3), -1021C/ T ( DBH) and S/L ( SLC6A4). Paper-15134790. There were no direct associations between the IL-6 -174 G/C, 5-HTT 44 bp insertion-deletion, and MAO-A 30 bp VNTR gene polymorphisms and endurance performance in the 2000 and (or) 2001 South African Ironman Triathlons. Paper-14584897. It has been demonstrated that the interaction between serotonin transporter ( 5HTT) and norepinephrine transporter (NET) functions affects each transporter function and behavior in studies using knockout mice model. Paper-12823034. Promoter region polymorphisms ( 5-HTTLPR) of the serotonin transporter gene ( SLC6A4) and the 5-HT2A receptor gene ( HTR2A) have been studied as potential candidate genes in autism spectrum disorder (ASD). Paper-13137617. Gene-environment interaction in psychiatric disorders as indicated by season of birth variations in tryptophan hydroxylase ( TPH), serotonin transporter ( 5-HTTLPR) and dopamine receptor ( DRD4) gene polymorphisms. Paper-9910285. BACKGROUND: Family-based evidence for association at serotonin system genes SLC6A4, HTR1B, HTR2A, and brain-derived neurotrophic factor ( BDNF) has been previously reported in obsessive-compulsive disorder (OCD). Paper-12433814. The integrin beta3 ( ITGB3) and serotonin transporter ( SLC6A4) genes were both recently identified as male quantitative trait loci (QTLs) for serotonin levels and alleles of each have been associated with autism. Paper-12139528. This first study on the role of both OXTR and 5-HTT genes in human parenting points to molecular genetic differences that may be implicated in the production of oxytocin explaining differences in sensitive parenting. Paper-14338638. No significant differences in genotype distribution or allele frequencies were identified for 5-HTTLPR or 5-HTTVNTR between AD patients and age- and sex-matched non-demented controls regardless of ApoE epsilon4 allele. Paper-12631085. Genetic polymorphisms in several genes ( TPH2, SLC6A4, HTR1A, HTR2A, COMT, and BDNF) were tested as predictors of relapse (defined as any drinking during follow-up) while controlling for baseline measures. Paper-13694153. The association between NS and ANX/DEP ALC only existed in subjects with DRD2 TaqI A1(+) allele (A1/A1 or A1/ A2 genotypes) (p = 0.004) and in those with S/ S genotype of 5-HTTLPR (p = 0.005). Paper-13413395. In this study we used in situ hybridization and real-time PCR to study the gene expression of monoamine transporters, such as NET, SERT, VMAT2, EMT and OCT1/2, in normal as well as in pre-eclamptic placentae. Paper-10425201. The evidence for an effect of specific genes was modest, however, and evidence indicated substantial between-study heterogeneity in most cases, with the exception of the effects of the 5HTT and CYP2A6 genes on smoking cessation. Paper-10906688. Out of the 17 genes we reviewed, 8 genes were entered into the meta-analysis ( SLC6A4, HTR1A, HTR2A, TPH1, gene encoding the beta-3 subunit, brain-derived neurotrophic factor ( BDNF), HTR3A and HTR3B). Paper-14517845. The aim of this study was to determine whether there were any associations between polymorphisms within the ACE, BDKRB2, NOS3 and/or 5-HTT genes with weight changes during the 2000 and 2001 226 km South African Ironman Triathlons. Paper-12251798. RESULTS: We found a significant interaction between the development of depressive symptoms in the course of pregnancy and polymorphisms in 5-HTT (p=0.019); MAOA (p=0.044) and COMT (p=0.026), and MAOA x COMT (p<0.001). Paper-13977425. Potential relevant OCD phenotypes founded on age of onset, positive family history for OCD, clinical subtypes, comorbidity and symptom severity were stratified according to 5-HTT, 5-HT1B and 5-HT2A genotypes. Paper-11345251. The serotoninergic system is believed to be involved in suicidal behavior and there is evidence of biological abnormalities of two serotonin receptors ( HTR2A, HTR2C) and one serotonin transporter ( 5HTT) in suicide victims. Paper-12725775. We observed an additive effect of COMT and both 5-HTT polymorphisms, accounting for 40% of the inter-individual variance in the averaged BOLD response of amygdala, hippocampal and limbic cortical regions elicited by unpleasant stimuli. Paper-13132305. Although these data should be interpreted cautiously due to the small sample size, these results implicate TPH1 and SLC6A4 in general response, and HTR2A, TPH2, and MAOA in the specificity of response to fluoxetine. Paper-10642926. We found no significant differences for any measured parameter according to the eNOS, 5- HTR2A and the 5-HTT polymorphisms, although there was a higher allelic frequency of the 5-HTT long variant in IPAH than in CTEPH and controls. Paper-14651240. The levels of MAPK phosphorylation, 5-HTT mRNA expression and 5-HT uptake all increased in the IFN-alpha-treated cells but were blocked in those that were pretreated with MAPK inhibitors and fluoxetine. Paper-12978381. Mini-Mental State Examination (MMSE), Activities of Daily Living ( ADL), and Instrumental Activities of Daily Living (IADL) scores, socio-economic status and 5-HTTLPR and APOE gene polymorphisms were determined for each subject. Paper-13584064. Polymorphisms in catechol-O-methyltransferase, tryptophan hydroxylase ( TPH1), serotonin receptor 2C ( HTR2C) and serotonin transporter ( SLC6A4) genes were identified and associated with bodyweight gain during treatment. Paper-13848342. Our findings indicate that the DRD2 -141C Ins allele and the 5-HTTLPR S allele are genetic risk factors for alcoholism in Mexican-Americans, and that smoking modulates the association between genetic risk factors and alcoholism. Paper-10555217. METHODS: In 59 COPD patients who underwent right heart catheterization, 6-min walking distance, NYHA functional class, pulmonary function tests, blood gases and 5HTT, 5HTR2a and eNOS (4ab and T298C) polymorphisms were determined. Paper-14124744. Polymorphisms within the DRD1, DRD2, DRD3, DAT1, 5-HTTLPR and HTR2A genes are being studied for association with lithium prophylaxis in a sample of 155 Sardinian unrelated probands affected by bipolar disorder (BP). Paper-13977469. METHODS: We evaluated the role of three polymorphic genes related to alcohol metabolism ( CYP2E1) and, possibly, dependence ( DRD2 and SLC6A4 promoter) in a series of 60 alcoholics admitted to a specialized referral center in Florence, Italy. Paper-8710202. RESULTS: Polymorphisms in PDE1A, PDE1C, PDE6A, PDE11A, ABCB1, GRIK4, SLC6A4, and OPRM1 genes showed no statistically significant associations (uncorrected, two-tailed p > .05) with duloxetine treatment response. Paper-15100601. BACKGROUND: We explored the relationship of genetic variants of the serotonin transporter gene SLC6A4, a key regulator of the serotonergic neurotransmission, with both depressive symptoms and plasma interleukin-6 ( IL-6) levels. Paper-14621710. Pyridoxine treated alone and in combination with insulin, A. marmelose to diabetic rats reversed the B(max), K(d) of 5-HT, 5-HT(2A) and the gene expression of SOD, GPx, 5-HT(2A) and 5-HTT in cerebellum to near control. Paper-15076114. Using functional magnetic resonance imaging, we assessed the effects of COMT Val(158)Met and both 5-HTT genotypes on brain activation by standardized affective visual stimuli (unpleasant, pleasant, and neutral) in 48 healthy subjects. Paper-13132305. We examined the effects of serotonin transporter-linked promoter region ( 5-HTTLPR) and dopamine transporter ( DAT1) gene polymorphisms for associations with the Temperament and Character Inventory (TCI) temperament subscales in 209 Koreans. Paper-12133134. Norepinephrine transporter (NET), serotonin transporter ( SERT), vesicular monoamine transporter ( VMAT2) and organic cation transporters ( OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies. Paper-10425201. By performing Western blotting, real-time reverse transcriptase-polymerase chain reaction and [3H]5-HT labelling, we examined MAPK phosphorylation, 5-HTT mRNA expression and 5-HT uptake in Jurkat T cells. Paper-12978381. The polymorphisms were TPH (A779C), 5-HT transporter ( 5-HTT, LPR S/L), monoamine oxidase A ( MAOA G941T), 5-HT1B receptor ( HTR1B G861C), 5-HT2A receptor ( HTR2A T102C), and 5-HT2C receptor ( HTR2C Cys23Ser). Paper-9918691. The most significant models contributing to serotonin distribution were found for interactions between TPH1 rs4537731 and SLC6A4 haplotypes ( P = 0.002) and between HTR1D rs6300 and SLC6A4 haplotypes ( P = 0.013). Paper-13150896. A sample of alcoholics and normal controls were screened with the variations in tryptophan hydroxylase ( TPH), serotonin receptors ( 5-HT2A and 5-HT2C), serotonin transporter ( 5-HTT), and monoamine oxidase A ( MAO-A) genes. Paper-8923449. Many studies investigated the association between MDD and BD with the 5-HT2A 102 T/C, the 5-HTT promoter 44 bp insertion/deletion and the intron 2 VNTR polymorphisms, and thus, these could be pooled using meta-analytic techniques. Paper-9921213. Multiple 'variability genes' were found for longitudinal change in a semantic memory task including candidates coding for apolipoprotein E ( APOE) and estrogen receptor alpha ( ESR1) as well as serotonin candidates ( HTR2A and 5HTT). Paper-13287980. Individuals of lower income and less education had lower peak PRL concentrations following administration of fenfluramine than did subjects ranking higher on these dimensions, but only among persons possessing at least one 5-HTTLPR short allele. Paper-10205894. The combined evidence was significant for association with the 5-HTT locus (Mantel-Haenszel weighted odds ratio (M-H(w) OR)=1.17 CI : 1.04-1.32, P=0.009), but not for the 5-HT2A 102 T/C variant (M-H(w) OR)=1.09 CI : 0.93-1.27, P=0.319). Paper-9932275. The polymorphism of the genes related to the activity of serotonin ( 5-HT) and dopamine (DA)-systems (such as 5-HTT, 5HT2a, MAOA, DAT, DRD2, COMT) was determined upon the basis of DNA analysis according to a standard procedure. Paper-15417104. We screened for variants in the complete coding sequence and intron-exon junctions of two candidate genes for neuropsychiatric phenotypes: SLC6A4, encoding the serotonin transporter; and SLC18A2, encoding the vesicular monoamine transporter. Paper-8713746. We report a significant main effect of the HTR5A gene in autism ( P = 0.0088), and a significant three-locus model comprising a synergistic interaction between the ITGB3 and SLC6A4 genes with an additive effect of HTR5A ( P < 0.0010). Paper-13150896. Two intronic SNPs, one at the serotonin transporter gene ( SLC6A4) and another at dopa decarboxylase ( DDC), were significantly associated to STAI anxiety scores after multiple testing correction (nominal P=0.0000513 and 0.000097, respectively). Paper-15160505. These results appear to clarify the association of depression with IFN-alpha-induced 5-HT uptake that reduces the 5-HT levels and IFN-alpha-regulated transcription of 5-HTT; further, the results suggest the involvement of MAPK in this process. Paper-12978381. The aim of this study was to investigate seven genetic variants in three genes ( serotonin transporter ( 5-HTT), serotonin receptor 1B (5- HTR1B) and serotonin receptor 2A (5- HTR2A)), which have previously been shown to be associated with ADHD. Paper-12468342. Psychopathy trait scores were assessed [total scores and 'emotional dysfunction' (also referred to as 'affective') scores] and the MAOA 30-bp variable number of tandem repeats, SLC6A4 44-bp insertion/deletion and COMT Val158Met variants were genotyped. Paper-14088295. While mean velocities of 5HTT kinetics did not significantly differ among the groups, significant elevation in the mean velocity of MAOB kinetics was observed in NS subjects and was even more pronounced in HS subjects in comparison to controls. Paper-13721163. Our results indicate that genetic associations are stronger when stratified by sex and in the same direction as the previous neurobiological studies indicate: associations were stronger in males for COMT, SLC6A4 and stronger in females for SLC6A2, MAOA. Paper-14340221. In a clinical sample of 266 children with ADHD, we tested for interaction between gene variants (in DRD4, DAT1, DRD5, and 5HTT) found to be associated with ADHD in pooled analyses and maternal smoking, alcohol use during pregnancy and birth weight. Paper-12671896. However, assessment of the combined influence of 5-HT2A A-1438G and 5-HTTLPR polymorphisms demonstrated a significant effect (chi(2) (3)=11.51, p=0.009), whereby the combination of -1438A and 5-HTTLPR S alleles was associated with schizophrenia. Paper-13160562. All subjects were assessed with the State-Trait Anger Expression Inventory (STAXI) and were genotyped for 3 polymorphisms: serotonin transporter (5-HTT) gene-linked polymorphic region ( 5-HTTLPR), tryptophan hydroxylase 1 ( TPH1) A218C, and TPH2 G-703T. Paper-15334999. In the presence of the DAT1 10/10 genotype, subjects of group L of 5-HTTLPR had a significantly higher HA score and significantly lower RD score than those of group S ( F = 5.04, df = 1, p = 0.03 and F = 8.35, df = 1, p = 0.004, respectively). Paper-12133134. Evidence indicated effects of the DRD2 Taq1A polymorphism and smoking initiation, the 5HTT LPR and CYP2A6 reduced-activity polymorphisms and smoking cessation, and the DRD2 Taq1A and CYP2A6 reduced-activity polymorphisms and cigarette consumption. Paper-10906688. Moreover, subjects with s homozygosity at the 5-HTTLPR and BDNF met carriers (16.2±7.9 ng/ml) had lower serum levels of BDNF as compared with those with l carriers of the 5-HTTLPR in combination with BDNF val homozygosity (21.7±4.4 g/ml) (p=0.024). Paper-15636919. Our haplotype and putative transcription binding profile analyses strongly suggest that certain constellations of CB1-receptor and 5-HTT promoters yield extremely high or low synaptic 5-HT concentrations, and these are associated with an anxious phenotype. Paper-14157123. Subjects homozygous for the L allele (with high 5-HTT expression) showed the lowest GH response, whereas those homozygous for the S allele (with low 5-HTT expression) showed the highest GH response (this was intermediate in heterozygous participants). Paper-14658737. We collected 225 independent subjects (74 sporadic FTLD and 151 age-matched healthy controls, CT) that were genotyped for the rs4795541, the SLC6A4 single nucleotide polymorphisms (SNP) rs25531 and rs6354, and the apolipoprotein E ( APOE) allelic variants. Paper-13483063. BACKGROUND: The pathophysiology of tardive dyskinesia (TD) is not completely understood.Aim. - To assess the relationship of TD with 5-HT2A receptor gene, serotonin transporter gene ( 5 HTT), and catechol-o-methyltransferase ( COMT) gene polymorphisms. Paper-10019581. Following gene polymorphisms were determined by the PCR method: ACE insertion/deletion (I/ D ACE), angiotensinogen ( AGT) (M 235), angiotensin II receptor (ATR1) (A 1166C) and serotonin transporter ( SERT) polymorphism (5HTTLPR). Paper-13747103. RESULTS: Variations in the catecholamine metabolizing enzyme genes ( MAOA and COMT) showed significant associations with the maximum post-operative pain rating while the serotonin transporter gene ( SLC6A4) showed association with the onset time of post-operative pain. Paper-12175545. These studies reveal cellular phenotypes associated with naturally occurring human SERT coding variants and suggest that altered transporter regulation by means of PKG/ p38 MAPK-linked pathways may influence risk for disorders attributed to compromised 5-HT signaling. Paper-11047657. The overall results implicate SLC6A4 and ITGB3 gene interactions in autism etiology and in serotonin level determination, providing evidence for a common underlying genetic mechanism and a molecular explanation for the association of platelet hyperserotonemia with autism. Paper-13150896. The 5-HTTLPR was genotyped in 139 adult men and women (n = 75 and 64) who were administered a standard neuroendocrine challenge to assess central serotonergic responsivity (plasma prolactin ( PRL) response to the serotonin releasing agent, fenfluramine). Paper-10205894. Polymorphic markers at catechol O-methyltransferase ( COMT), serotonin transporter ( 5-HTT), and tryptophan hydroxylase ( TPH) genes were analyzed in a case-control association study of bipolar disorder patients with or without lifetime panic disorder. Paper-9153578. CONCLUSIONS: Abnormal hippocampal and lateral ventricular volumes are among the most replicated endophenotypes for psychosis; however, the influences of COMT, BDNF, 5-HTT, NRG1 and DTNBP1 genes on these key brain regions must be very subtle if at all present. Paper-14029703. The aim of the current paper is to determine whether particular alleles or genotypes of two crucial genes of these systems, the serotonin transporter gene ( SLC6A4) and the brain-derived neurotrophic factor gene ( BDNF), are associated with mental deficiency (MD). Paper-14273777. METHODOLOGY/PRINCIPAL FINDINGS: We tested the impact of 5HT-stimulation on vimentin- SERT association and found that 5HT-stimulation accelerates the translocation of SERT from the plasma membrane via enhancing the level of association between phosphovimentin and SERT. Paper-13654445. However, taking in account OCD phenotypes, we found indication towards an association of the 5-HTTLPR S-allele with female OCD patients, and the 5-HT2A G-allele and GG genotype with patients with a positive family history of OCD and an early onset of disease. Paper-11345251. The purpose of the present study was to determine whether norepinephrine transporter gene (NET) and serotonin transporter gene ( 5-HTT) polymorphisms are associated with the antidepressant response to milnacipran, a dual serotonin/ norepinephrine reuptake inhibitor. Paper-10561660. METHODS: The present study examined associations between the 5-HTTLPR polymorphism of the SLC6A4 gene, the Val66Met polymorphism of the brain-derived neurotrophic factor ( BDNF) gene, and cognitive reactivity in a never depressed, unmedicated, young adult sample (N=151). Paper-15188843. We investigated the relationship of a polymorphism in the 5' promoter region of the serotonin transporter gene ( 5-HTTLPR) with prolactin ( PRL) response to meta-chlorophenylpiperazine (m-CPP) in a sample of 68 African-American individuals, 35 CD subjects and 33 controls. Paper-12303238. In the current study, 85 current performing dancers and their parents were genotyped for the serotonin transporter ( SLC6A4: promoter region HTTLPR and intron 2 VNTR) and the arginine vasopressin receptor 1a (AVPR1a: promoter microsatellites RS1 and RS3). Paper-11479782. To test this possibility, data from the National Longitudinal Study of Adolescent Health (Add Health) were used to examine the effects that five different genetic polymorphisms ( DAT1, DRD2, DRD4, 5HTT, and MAOA) have on desistance from delinquent involvement. Paper-13502530. Whereas, the 5-HT1A receptor genotype did not show any significant effects on [11C]WAY 100635 binding, 5-HT1A receptor binding potential values were lower in all brain regions in subjects with 5-HTTLPR short (SS or SL) genotypes than those with long (LL) genotypes. Paper-11085738. The role in autism etiology of seven candidate genes in the serotonin metabolic and neurotransmission pathways and mapping to autism linkage regions ( SLC6A4, HTR1A, HTR1D, HTR2A, HTR5A, TPH1 and ITGB3) was analyzed in a sample of 186 nuclear families. Paper-13150896. In the 404 patients who completed the interview and the 559 Korean healthy normal controls, genotyping was performed for variants of the DRD3 p.S9G, DRD2 Taq1A, GRIN2B c.366C>G, c.2664C>T and c.-200T>G, and the promoter region of the serotonin transporter gene ( 5-HTTLPR). Paper-13997188. Genotyping HD patients for DRD4 and 5-HTT polymorphisms and measuring PL concentrations, we report on an association between the combination DRD4*7/ 5HTT LL genotype and a reduced improvement in general functioning accompanied by different PL levels upon MPH treatment. Paper-9085834. METHODS: We genotyped five polymorphisms of the AGT, ACE, AT1R, 5-HT2A, and 5-HTT genes in 245 patients with Hypertrophic Cardiomyopathy (HCM; 205 without an identified sarcomeric gene mutation), in 145 patients with LVH secondary to hypertension, and 300 healthy controls. Paper-15285003. RESULTS: Relative to the comparison subjects, subjects with bipolar disorder without panic disorder, but not those with comorbid bipolar disorder and panic disorder, showed significantly higher frequencies of the COMT Met158 and the short 5-HTTLPR alleles and genotypes. Paper-9153578. Functional polymorphisms in the MAO-A uVNTR promoter gene, the COMT gene (Val158Met) exon 4, and the 5-HTT promoter gene (44 bp ins/del) were investigated in 101 patients with phobic disorders of the anxiety spectrum and 202 controls matched to the patients for sex, age and ethnicity. Paper-10624525. Molecular polymorphisms are discussed considering their functional role in regulating serotonin synthesis ( TPH2), neuronal reuptake ( 5-HTTLPR and 5-HTT intron 2), and catabolism ( MAOA) in the nervous system of Italian SIDS infants. Paper-12820474. There were no significant differences in the relative genotype distributions within the IL-6 (p = 0.636), 5-HTT (p = 0.659), and MOA-A (p = 0.227) polymorphisms when the fastest-fnishing, middle-finishing, and slowest-finishing triathletes, as well as the control groups, were compared. Paper-14584897. One hundred and eleven male patients with alcohol dependence and 123 nonalcoholic healthy men were tested for the genetic polymorphisms of alcohol dehydrogenase 2 ( ADH2), aldehyde dehydrogenase 2 ( ALDH2), serotonin transporter ( 5-HTT) and dopamine transporter ( DAT1). Paper-11328857. Differential sampling procedures may influence the proportion of AAO subgroups in a given association study, and therefore these results may explain the conflicting results obtained in studies of the association between the SLC6A4 gene polymorphism and bipolar affective disorder ( BPAD). Paper-9269039. We genotyped four single nucleotide polymorphisms ( SNPs), including GNB3 rs5443 (C825T), HTR1A rs6295 (C-1019G), HTR2A rs6311 (T102C), and SLC6A4 rs25533, and employed the generalized multifactor dimensionality reduction (GMDR) method to investigate gene-gene interactions. Paper-13977403. We investigated the genetic contribution of four single nucleotide polymorphisms ( SNPs) within the serotonin receptor 5HT2C and two sequence variants within the serotonin transporter SLC6A4 to different ED-related psychopathological symptoms in a total sample of 82 ED patients. Paper-12654495. These data suggest that G x E interactions predictive of depressive symptoms may be differentially sensitive to levels of childhood trauma, and the effects of child abuse are moderated by genetic variation at both the CRHR1 and 5-HTTLPR loci and by their G x G interaction. Paper-14681656. In the present study, we aimed to analyze the potential relevance of the polymorphism in the promoter region of the serotonin transporter ( SERT or 5-HTT) gene ( 5-HTTLPR) and the risk of suffering major depression (MDD) in a population of patients previously genotyped for CYP2C9. Paper-13343691. Using a high-throughput single-nucleotide polymorphism (SNP) genotyping platform and capillary electrophoresis, we genotyped patients at 110 SNPs and four repeat polymorphisms located in seven candidate genes ( HTR1A, HTR2A, HTR2C, MAOA, SLC6A4, TPH1, and TPH2). Paper-10642926. To determine allele-dose effects, the number of COMT Met158 alleles (i.e., lower activity of COMT) and the number of 5-HTT low expressing alleles ( S and G) was correlated with the blood oxygen level-dependent (BOLD) response to pleasant or unpleasant stimuli compared to neutral stimuli. Paper-13132305. Variants of the functional polymorphism in the serotonin transporter (upstream regulatory region: 5-HTTLPR), the tryptophan hydroxylase ( TPH), the monoamine oxidase A ( MAO-A), and the dopamine receptor D4 ( DRD4) genes have all been associated with mood disorders. Paper-9466551. Polymorphisms in the 5-HT2A (102 (T/C), His452Tyr), 5-HT2C (Cys23Ser, -759 (C/T), -995 (G/A), TPH2 (-366 (C/T), -8933 (A/G) and 5-HTT (LPR, -15370 (A/G)) genes were investigated in a cohort of 427 US Caucasian patients undergoing antipsychotic treatment, using automated genotyping techniques. Paper-14071585. Measures of psychiatric symptomatology and social supports were obtained using standard research instruments, and serotonin transporter ( 5-HTTLPR) (locus SLC6A4) and brain-derived neurotrophic factor ( BDNF) (variant val66met) genotypes were obtained from saliva-derived DNA specimens. Paper-11307101. Overall our results indicates that the HTR2A, 5-HTT, DRD3 and GABA(A)gamma2 genes are not likely to be a major genetic risk factor for heroin abuse in this population, with the exception of possible association between nasal inhalation and DRD2 promoter - 141DeltaC polymorphism. Paper-9200783. CONCLUSION: Our study suggests that the markers examined thus far in COMT and SLC6A4 are not associated with pediatric bipolar disorder and that if the val66met marker in BDNF is associated with pediatric bipolar disorder the magnitude of the association is much smaller than first reported. Paper-13612237. We performed a genetic association study using polymorphisms of five serotonin metabolism-related genes: serotonin transporter ( 5HTT), serotonin receptor 1A(5-HT1A), serotonin receptor 1B ( 5-HT1B), serotonin receptor 2A ( 5-HT2A) and serotonin receptor 6 (5HT6)genes. Paper-14216691. Tag Single Nucleotide Polymorphisms ( SNPs) (r(2)>0.8) were selected for serotoninergic system genes ( TPH2, SLC6A4 and HTR2A) and HPA axis genes ( CRH, CRHR1, CRHBP, MC2R, POMC, NR3C1, and SERPINA6) and genotyped using Sequenom technology. Paper-15249814. We have measured the activity of two platelet 5HT-associated proteins: 5HT transporter ( 5HTT) and monoamine oxidase B ( MAOB), and indirectly studied the activity of 5HT(2A) receptor (5HT(2A)r) in 15 hyperserotonemic (HS) and 17 normoserotonemic (NS) autistic subjects, and 15 healthy controls (C). Paper-13721163. They include the following genes/markers: Apolipoprotein E ( APOE), 5-hidroxytryptamine transporter length polymorphic region ( 5-HTTLPR), brain-derived neurotrophin factor ( BDNF), monoamine oxidase A ( MAO-A), and two simple-sequence tandem repeat polymorphisms (DXS1047 and D10S1423). Paper-13555221. Nine gene-candidates, including 5-HTTLPR, MAO-A VNTR, TPH2 rs1386494, 5- HTR1A -1019C-G, 5- HTR2A 102T-C, CCKR1 246G-A, CCKR2 -215C-A, DRD1 -94G-A and COMT Val158Met, were selected for genotyping based on previous positive findings from genetic association studies in PD. Paper-14344238. Cotransfection of HEK-293 cells with SERT and a constitutively active form of MAP kinase kinase 3b(E) [MKK3b(E)] increased 5-HT transport, and RNA interference targeted to p38 MAPK inhibited 5-HT uptake, confirming the involvement of active p38 MAPK in SERT expression. Paper-10759515. This study aimed to investigate whether three serotonergic polymorphisms ( HTR2A A-1438G (rs6311), and SCL6A4 5-HTTLPR and STin2 VNTR) were associated with alcohol dependence, and, whether the serotonergic polymorphisms played a similar role in conferring vulnerability in alcohol and heroin dependence. Paper-13759567. A single amino acid mutation, cysteine-201 to alanine, within the conserved cytoplasmic E peptide of SCAMP2, abolished SCAMP2- mediated down-regulation of SERT, although this mutation had no effect on the physical interaction between SERT and SCAMP2. Paper-12242696. METHODS: We analyzed four functional polymorphisms (rs25531, 5-HTTLPR, VNTR, rs3813034) of the SLC6A4 gene and one functional polymorphism (Val66 Met) of the BDNF gene in 98 patients with non-syndromic mental deficiency (NS-MD) and in an ethnically matched control population of 251 individuals. Paper-14273777. By including individuals varying in their degree of susceptibility to MD, we showed evidence of interactions between 5-HTT and MD susceptibility in baseline cortisol, and between MAOA and MD susceptibility in baseline ACTH measures, indicating a role for these genotypes in stable-state endocrine regulation. Paper-13200921. The association between the IL-6 polymorphism and reduced risk of depressive symptoms confirms the role of the inflammatory response system in the pathophysiology of IFN-alpha-induced depression; in contrast, the effect of the 5-HTT gene was small and perhaps dependent on the status of the inflammatory response. Paper-13077074. Although the 5-HIAA concentration showed a tendency to be higher in short (S) carriers than in non-S carriers of the 5-HTTLPR in patients (p=0.06), when considering patients with major depressive disorder ( MDD), the 5-HIAA concentration was significantly higher among S carriers than among non-S carriers (p=0.02). Paper-12494206. Furthermore, during a 3-week moderate endurance training of sedentary males basaline values of Bmax of 5-HT transporters ( 5-HTT) and 5-HT2A receptors (5-HT(2A)R) on isolated platelet membranes increased while plasma prolactin ( PRL) concentrations decreased as well as mood and physical efficiency improved. Paper-8829672. METHODS: We investigated polymorphisms in two serotonin-receptor genes, HTR1B and HTR2A, and the serotonin transporter ( SLC6A4) in two independent samples of patients with childhood-onset mood disorders (COMD): 203 patients from Pittsburgh, USA with matched controls and 448 small families from Hungary. Paper-14374563. METHODS: In 156 Caucasian BPD patients and 152 healthy controls, we tested for association between BPD and the TH Val(81)Met SNP, the 5-HTTLPR/rs25531 polymorphism, the STin2, the interaction of the TH Val(81)Met SNP with the tri-allelic 5-HTTLPR/rs25531, the interaction of the TH Val(81)Met SNP with STin2. Paper-14245385. METHODS: With a 2-year prospective study of a community sample ( N = 521) of older people (aged 65+), information on baseline number of health complaints, diagnosis of moderate/severe depressive syndrome (Geriatric Mental State), and genotypes for 5-HTTLPR and MTHFR C677T polymorphisms were ascertained. Paper-13717916. Investigators have demonstrated that recombinant human IL-6 administration and serotonergic neurotransmission manipulation, with 5-hydroxytryptamine transporter ( 5-HTT) and monoamine oxidase A ( MAO-A) inhibitors, prior to exercise, can alter running performance, consistent with a central governor hypothesis. Paper-14584897. BACKGROUND: Polymorphisms in the brain-derived neurotrophic factor ( BDNF) val66met and serotonin transporter gene- linked promoter region ( 5-HTTLPR) are associated with alterations in mood and BDNF protein, but the effects of two genetic variations on the serum level of BDNF is unclear. Paper-15636919. The genotype frequencies of the dopamine type 2 receptor gene ( DRD2), aldehyde dehydrogenase type 2 gene ( ALDH2), functional polymorphism in the regulatory region of the serotonin transporter gene ( 5-HTTLPR), and catechol-O-methyltransferase gene ( COMT) polymorphisms were examined. Paper-12127286. For the eight genes for which the same variant has been studied in three or more case-control or family-based studies, seven show statistically significant evidence of association with ADHD on the basis of the pooled odds ratio across studies: DRD4, DRD5, DAT, DBH, 5-HTT, HTR1B, and SNAP-25. Paper-10796019. The present study sought to evaluate the relationship between such behavioral endophenotypes in AD and genetic variations in dopamine- or serotonin-related genes, such as catechol-O-methyltransferase ( COMT) or 5-HTT gene- linked promoter region ( 5-HTTLPR), and apolipoprotein E ( APOE). Paper-12233516. A variable number of tandem repeats (short (S) vs long (L)) in the promoter region of the serotonin transporter gene ( 5-HTTLPR) and a functional variant of a single-nucleotide polymorphism (rs25531) in 5-HTTLPR have been recently associated with increased risk for major depressive disorder ( MDD). Paper-14278256. In both groups we genotyped 11 genetic variations (rs1800587; rs3087258; rs1799724; 5-HTTLPR; rs1386493; rs1386494; rs1487275; rs1843809; rs4570625; rs2129575; rs6313) located in genes whose impact on alcohol related behaviors and disorders has been hypothesized ( IL1A, IL1B, TNF, 5-HTTLPR, TPH2 and HTR2A). Paper-13982907. OBJECTIVE: To investigate (i) the association between four serotonergic polymorphisms (A-1438G and T102C of the 5-HT2A receptor gene, and 5-HTT VNTR and 5-HTTLPR of the 5-HT transporter gene) and schizophrenia and (ii) the potential interaction of those polymorphisms in the development of schizophrenia. Paper-13160562. Very few or no significant associations were seen for the DRD2/ANKK1 TaqIA polymorphism, the serotonin transporter promoter VNTR or 5HTTLPR ( SLC6A4), the dopamine transporter 3' VNTR ( SLC6A3), and the mu opioid receptor A118G single nucleotide polymorphism ( mu opioid receptor polymorphism 1). Paper-12965353. The P values of odds ratios to habitual smoking for CYP17A1, ESR1, EPHX1, GSTT2, ALDH2, NOS2A, OGG1, and SLC6A4 and those of odds ratios to habitual drinking for CYP1B1, ESR1, HSD17B3, GSTM3, COMT, ADH1C, ALDH2, NOS3, and NUDT1 were under 0.05. Paper-11282139. In the present study, we investigated a polymorphism in the promoter region of the serotonin transporter ( SLC6A4) and two polymorphisms (-1438 A > G and His452Tyr) in the serotonin 5- HTR2A receptor gene using family based association analyses in a sample of 243 Brazilian ADHD children and adolescents and their parents. Paper-12385119. Here, we show that polymorphic variations in genes coding for serotonin transporter ( 5-HTT), catechol-O-methyl transferase ( COMT) and monoamine oxidase A ( MAOA) as well as sex differences influence the regulation of hypothalamic-pituitary-adrenal (HPA)-axis response to acute psychological and endocrine challenges. Paper-13200921. Suggested mechanisms for hyperserotonemia in autism have been increased synthesis of serotonin (5HT) by tryptophan hydroxylase ( TPH), increased uptake into platelets through 5HT transporter (5HTt), diminished release from platelets through 5HT2A receptor (5HT2Ar) and decreased metabolism by monoamine oxydase ( MAOA). Paper-14307654. Four hundred sixty-eight male Caucasian triathletes who completed the 2000 and (or) 2001 South African Ironman Triathlon and 200 healthy Caucasian male controls were genotyped for the -174 IL-6 G/C, 5-HTT 40 base pair (bp) insertion-deletion and 30 bp variable number of tandem repeats ( VNTR) MAO-A gene polymorphisms. Paper-14584897. Genotypes and allelic frequencies of TPH2, 5-HTTLPR, the 5-HTT ( SLC6A4) intron 2 variable-number tandem repeat (VNTR) region, and the MAOA VNTR region were determined in brain-stem samples of 20 "genuine" SIDS cases and compared with results obtained from 150 healthy controls. Paper-12820474. OBJECTIVE: Applying a probabilistic learning task we examined the influence of functional polymorphisms of the serotonin transporter gene ( 5-HTTLPR) and the D2 dopamine receptor gene ( DRD2/ ANKK1) on error and feedback processing by measuring electrocortical event-related potentials (ERPs) in 10- to 12-year-old children. Paper-13570222. We tested four genes [ phenylalanine hydroxylase ( PAH), the serotonin transporter ( SLC6A4), monoamine oxidase B ( MAOB), and the gamma-aminobutyric acid A receptor beta-3 subunit ( GABRB3)] for their impact on five schizophrenia symptom factors: delusions, hallucinations, mania, depression, and negative symptoms. Paper-13691070. The aim of the present observational study was to assess the value of the C825T polymorphism of the beta-3 subunit of G proteins ( GNB3) as well as of variants in the SLC6A4 gene (5HTTLPR and STin2 VNTR) and DRD2 gene (TaqI A and NcoI) as predictive markers for consistency in headache response to triptans in migraine patients. Paper-15214034. Twenty-day-old offspring (P21) brains were processed and immunoreactivity (IR) using antibodies against tryptophan hydroxylase ( TPH), 5-HT, 5-HT transporter ( 5HTT), glial fibrillary acidic protein ( GFAP), S-100B protein, 200-kDa neurofilaments (Nf-200) and neuronal nitric oxide synthase (nNOS) was evaluated. Paper-10131937. In this study, nine polymorphisms in four serotonin receptor genes ( HTR1B, HTR2A, HTR5A and HTR6) and the serotonin transporter gene ( SLC6A4) were analysed to investigate their influence on antidepressant response in a well-characterized unipolar depressive population (n=166) following a protocolized treatment regimen. Paper-12773123. In a general population sample of 607 Italian preadolescents, we examined the independent and joint effects of SES and the dopamine receptor D4 ( DRD4) and serotonin transporter linked promoter region ( 5-HTTLPR) polymorphisms upon rule-breaking and aggressive behaviors measured with the Child Behavior CheckList/6-18. Paper-12572437. In the present case-control study we investigated possible associations between PD phenotype and five candidate polymorphisms including 5-HT transporter ( 5-HTTLPR and VNTR), monoamine oxidase A ( MAOA promoter region), tryptophan hydroxylase 1 ( TPH1 218A/C) and 5-HT1B receptor (5-HT1BR 861G/C) genes. Paper-11520814. Those polymorphic sites include alcohol dehydrogenase ( ADH1B, ADH1C), aldehyde dehydrogenase ( ALDH2), cytochrome P-450 2E1 ( CYP2E1) TaqI, DraI, RsaI, dopamine D2 receptor ( DRD2) TaqI A, B, intron 6, exon 7, -141C Ins/Del, serotonin transporter ( 5-HTTLPR), and GABAA receptor beta3 subunit (GABRbeta3). Paper-10610938. Six polymorphisms in four genes related to the serotonin system, including the HTTLPR and HTTVNTR in the SLC6A4 gene, rs6295 in the HTR1A gene, rs11568817 and rs130058 in the HTR1B gene, and rs6313 in the HTR2A gene, were studied in 420 patients with MD to investigate the relationship between these genes and suicidal ideation in MD. Paper-14585299. Across 118 meta-analyses, a total of 24 genetic variants in 16 different genes ( APOE, COMT, DAO, DRD1, DRD2, DRD4, DTNBP1, GABRB2, GRIN2B, HP, IL1B, MTHFR, PLXNA2, SLC6A4, TP53 and TPH1) showed nominally significant effects with average summary odds ratios of approximately 1.23. Paper-12854626. Further, significant heterogeneity was observed for the associations between ADHD and DAT1, DRD4, DRD5, DBH, ADRA2A, 5HTT, TPH2, MAOA, and SNAP25, suggesting that future studies should explore potential moderators of these associations (e.g., ADHD subtype diagnoses, gender, exposure to environmental risk factors). Paper-13783758. We analyzed five genes, derived from pharmacological or translational mouse models, in a new case-control study of PD and SAD in European Americans: (1) the serotonin transporter ( SLC6A4), (2) the serotonin receptor 1A, (3) catechol-O-methyltransferase, (4) a regulator of g-protein signaling and (5) the gastrin-releasing peptide receptor. Paper-13529401. These genetic differences could be explained by various genes, the HTR1B, encoding the 5-HT(1) receptor subtype, MAOA gene that encodes the monoamino-oxidase, the main metabolic enzyme of this triptan, SLC6A4 (gene encoding the serotonin transporter) and DRD(2) (gene encoding the D(2) receptor), both involved in the pathogenesis of migraine. Paper-13302231. Those genes are ATP-binding cassette subfamily B member 1 ( ABCB1), the noradrenaline, dopamine, and serotonin transporters ( SLC6A2, SLC6A3 and SLC6A4), cyclic AMP-responsive element binding protein 1 ( CREB1), corticotropin-releasing hormone receptor 1 ( CRHR1) and neurotrophic tyrosine kinase type 2 receptor ( NTRK2). Paper-14579735. Food intake and weight gain were recorded, and plasma leptin, brain contents of serotonin ( 5-hydroxytryptamine; 5-HT), 5-hydroxy-indole-acetic acid (5-HIAA) and the raphe expression of tryptophan hydroxylase ( TPH), monoamine oxidase A ( MAO-A) and 5-HT reuptake transporter ( 5-HTT) genes were examined. Paper-12721094. There was a significant linear trend for the distribution of both the BDKRB2 +9/+9 genotype and the 5-HTT SS genotype between the three weight loss groups, with the >5% group having the highest percentage of athletes with the +9/+9 genotype (chi(2)=5.3, P=0.021) and the highest percentage of athletes with the SS genotype (chi(2)=5.8, P=0.016). Paper-12251798. A case group of males with type 2 alcoholism (N=59) and a control group of healthy males (N=282), both of Croatian origin, were analyzed for the frequency distribution of polymorphisms in 5HT transporter (5HTT-VNTR2, 5HTT-LPR), monoamine oxidase A (MAOA-uVNTR) and B (MAOB-A/G) and tryptophan hydroxylase 1 ( TPH1 A218C) and 2 ( TPH2 G-703T) genes. Paper-14307663. In our sample of 814 patients comprising 114 with schizophrenia, 416 with bipolar affective disorder and 284 with unipolar affective disorder, we studied interactions between the tryptophan hydroxylase ( TPH), the serotonin transporter ( 5-HTTLPR), and the dopamine receptor ( DRD4) genes in relation to five major psychiatric symptomatology scores. Paper-10772653. To address this issue, we looked for associations between markers in neurotransmitter genes (the serotonin transporter gene, 5-HTT; the serotonin receptor 2A, 5HT2A; the dopamine D2 receptor gene, DRD2; and the dopamine D4 receptor gene, DRD4) and the six styles of love as conceptualized by Lee (Eros, Ludus, Storge, Pragma, Mania and Agape). Paper-12652996. METHODS: In this exploratory study, we performed regression analyses with generalized estimating equations in patients with familial MDD (n=233) in order to explore whether a polymorphism in the serotonin transporter gene ( 5-HTTLPR) is differentially associated with MDD and a comorbid disorder compared with MDD without that particular comorbidity. Paper-13565457. METHODS: The role of polymorphisms in the serotonin receptor 1A ( 5-HT1A), serotonin receptor 2A ( 5-HT2A), and the serotonin transporter gene (5-HTT) promotor region ( 5-HTTLPR) in the manifestation of individual alcohol withdrawal symptoms was investigated in 97 Korean male inpatients with alcohol dependence and 76 Korean healthy male subjects. Paper-13551004. Using quantitative in situ hybridization, we measured messenger RNA (mRNA) levels of tryptophan hydroxylase ( TPH), 5-HT transporter ( 5-HTT), 5-HT1A and 5-HT1B autoreceptors, dopamine receptor-D2 ( DR-D2) autoreceptors and postsynaptic receptors, and dopamine receptor-D1 ( DR-D1) postsynaptic receptors, in discrete brain regions of HCR and LCR. Paper-12241720. These synonyms are used for gene SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4): Solute carrier family 6 member 4, Sodium-dependent serotonin transporter, SERT, OCD1, HTT, hSERT, 5HT transporter, 5-HTTLPR, 5-HTT, 5HTT. These accession numbers are used for gene SLC6A4: L05568 (NCBI_GENBANK__AC), B3VRV5 (UNIPROT__AC), B3VRR5 (UNIPROT__AC), AK309538 (NCBI_GENBANK__AC). SLC6A4 is a homologue of slc6a4a (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4A) from Danio rerio. SLC6A4 is a homologue of SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4) from Pan troglodytes. SLC6A4 is a homologue of SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4) from Canis lupus familiaris. SLC6A4 is a homologue of SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4) from Bos taurus. SLC6A4 is a homologue of SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4) from Gallus gallus. SLC6A4 is a homologue of Slc6a4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4) from Mus musculus. SLC6A4 is a homologue of Slc6a4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4) from Rattus norvegicus. Important links ! iHOP - Information Hyperlinked over Proteins . Concept & Implementation by Robert Hoffmann.