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PTPN22 and rheumatoid arthritis: gratifying replication. Paper-11077602.
We could not replicate association with HLA-DRB1 and PTPN22. Paper-13461899.
HLA, PTPN22 and CTLA4 are known to be involved in immune regulation. Paper-12768771.
PTPN22 and CTLA4 were not associated with erosive phenotype. Paper-12752261.
For the candidate genes, we found strong signals for PTPN22 and SUMO4. Paper-13461856.
The PTPN22 1858T variant was associated with future development of RA. Paper-12336974.
HLA , CTLA-4 and PTPN22 : the shared genetic master-key to autoimmunity? Paper-11526175.
DESIGN: Study of p53 and PTPN22 polymorphisms in women with endometriosis. Paper-12892562.
Modeling of PTPN22 and HLA-DRB1 susceptibility to rheumatoid arthritis. Paper-13461867.
Epistasis between the FCRL3 -169C and the PTPN22 1858T variants was also examined. Paper-12367742.
In this study we have analyzed SNPs in PTPN22 and CTLA-4 in patients with AAU. Paper-13595141.
CONCLUSION: We found no association between PTPN22 and RA in a Japanese population. Paper-12279563.
Joint effects of HLA, INS, PTPN22 and CTLA4 genes on the risk of type 1 diabetes. Paper-12768771.
Analysis of PTPN22 genotype distribution in relation to p53 genotypes. Paper-12892562.
Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22. Paper-13610934.
These results are further evidence that the PTPN22 gene confers autoimmune susceptibility. Paper-13027235.
The association of PTPN22 with rheumatoid arthritis and juvenile idiopathic arthritis. Paper-11382014.
Grb2 was co-immunoprecipitated with Lyp in 293T cells overexpressing both proteins. Paper-9197443.
PTPN22 is genetically associated with risk of generalized vitiligo, but CTLA4 is not. Paper-12827926.
Association of the PTPN22 locus with rheumatoid arthritis in a New Zealand Caucasian cohort. Paper-11077647.
At baseline, ACPA were measured and the PTPN22 C1858T and HLA-DRB1 genotypes determined. Paper-13298606.
In Silico Screening for PTPN22 Inhibitors: Active Hits from an Inactive Phosphatase Conformation. Paper-13667626.
There was no significant difference of fascin expression within the histological subtypes of LyP. Paper-9297632.
CONCLUSION: The PTPN22 gene is a joint susceptibility locus for AITD (especially HT) and T1D. Paper-13603912.
CCR4 was expressed in 11 of 12 (92%) cases of PCALCL, but in only two of 13 (15%) cases of LyP. Paper-11819891.
These data increase the likelihood that ADAM33, CDKAL1, and PTPN22 are true psoriasis-risk genes. Paper-13610934.
Examples include the murine Roquin and Ncf1 genes, and the PTPN22 gene identified in humans. Paper-12137681.
CXCR3 was expressed in 11 of 13 (85%) cases of LyP, but in only one of 12 (8%) cases of PCALCL. Paper-11819891.
The result suggests that the PTPN22 gene is associated with RA only in a specific ethnic group. Paper-12279563.
FAM- LyP-1-abraxane co-localized with extravascular islands expressing its receptor, p32. Paper-13617888.
Haplotype analysis revealed no association between the PTPN22 gene and RA in a Japanese population. Paper-12279563.
Co-expression of Lyp and Bcr-Abl in Cos-7 cells resulted in decreased levels of Bcr-Abl, Grb2, and Myc. Paper-9791592.
Simpler methods used include MP2, B3- LYP, BMK, and MPWB1K in association with the 6-311+G(3df,2p) basis set. Paper-12098870.
Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. Paper-10480305.
Association analysis of the PTPN22 gene in childhood-onset systemic lupus erythematosus in Mexican population. Paper-12347620.
Haplotype analysis also revealed that PTPN22 gene was not associated with RA in a Japanese population. Paper-12279563.
The adequacies of other currently used quantum chemical methods, MP2, CCSD(T), B3 LYP, and BLYP, are discussed. Paper-13097301.
RESULTS: There was no significant association between PTPN22 620W, CTLA-4 -318C/T, or CTLA-4 49A/G and AAU. Paper-13595141.
INTRODUCTION: PTPN22, PADI-4, and CTLA-4 have been associated with risk for rheumatoid arthritis (RA). Paper-13084277.
OBJECTIVE Specific alleles of non-HLA genes INS, CTLA-4, and PTPN22 have been associated with type 1 diabetes. Paper-13694935.
PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background. Paper-13675057.
RECENT FINDINGS: The second risk factor for rheumatoid arthritis, the PTPN22 polymorphism, has been identified. Paper-10785553.
Lyp1 was found to be constitutively associated with the proto-oncogene c-Cbl in thymocytes and T cells. Paper-1772368.
In our cohort of 496 MS trios from the United Kingdom, we observed reduced transmission of the PTPN22 620W allele. Paper-11406071.
We found no association between PTPN22 and the presence of the HLA-DRB1 shared epitope or clinical characteristics. Paper-12152312.
CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells. Paper-13668181.
BACKGROUND/HYPOTHESIS: HLA, INS, PTPN22 and CTLA4 are considered to be confirmed type 1 diabetes susceptibility genes. Paper-12768771.
Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis. Paper-13183520.
The past few years have seen the identification of PTPN22 and the confirmation of CTLA-4 as common autoimmune disease genes. Paper-11372442.
These patients and 6,866 geographically matched control subjects were genotyped at CTLA4, PTPN22, HLA-DRB1 and HLA-DQB1. Paper-13136932.
CONCLUSION: The PTPN22 620W allele appears to be involved in the pathogenesis of WG, and ANCA positivity seems to be the hallmark. Paper-11506297.
METHODS: A population-based study was performed for the PTPN22 polymorphism in 199 patients with WG and in 399 healthy individuals. Paper-11506297.
Five risk loci have been identified and validated: HLA-DRB1, PTPN22, STAT4, a region in 6q23, and the TRAF1/C5 locus. Paper-13741289.
The PTPN22 association with RA was greater in the absence than in the presence of the FCRL3 -169C allele (P = 0.0008 versus P = 0.001). Paper-12367742.
RANTES was strongly expressed by lymphoma cells in PCALCL (11 of 12: 92%), but was weak or sporadic in LyP (seven of 13: 54%). Paper-11819891.
The non-synonymous C1858T substitution in the PTPN22 gene is associated with susceptibility to the severe forms of alopecia areata. Paper-12141064.
Effects of PTPN22 C1858T polymorphism on susceptibility and clinical characteristics of British Caucasian rheumatoid arthritis patients. Paper-12152312.
Association of the PTPN22 C1858T single-nucleotide polymorphism with rheumatoid arthritis phenotypes in an inception cohort. Paper-11055678.
This study therefore examined whether the functionally relevant PTPN22 polymorphism is associated with Wegener's granulomatosis ( WG). Paper-11506297.
Potential interaction between risk haplotypes of PTPN22 and the PSORS1 associated risk allele was tested by regression analysis. Paper-12025493.
Previous linkage and candidate gene studies have identified several regions that predispose to RA, including the HLA-DRB1 and PTPN22. Paper-13461899.
Genotype analysis of polymorphisms in autoimmune susceptibility genes, CTLA-4 and PTPN22, in an acute anterior uveitis cohort. Paper-13595141.
Evaluating the role of the genetic variations of PTPN22, NFKB1, and FcGRIIIA genes in inflammatory bowel disease: a meta-analysis. Paper-12557063.
Here, we focus on the role of three phosphatases, CD45, CD148, and LYP/PEP, which are critical regulators of SFKs in hematopoietic cells. Paper-13668181.
The aim of this study was to test genetic association of the PTPN22 1858C>T variant and generalized vitiligo in a Romanian case-control cohort. Paper-12791337.
METHODS: The PTPN22 missense SNP was genotyped in 886 RA, 661 JIA, 279 psoriasis, 455 PsA, and 379 MS patients and in 595 healthy controls. Paper-11091329.
We present a comparative map of the Lyp region in rat and human, assigning the gene to a 1.3-Mb segment between RNY3 and ABP1 at 7q35. Paper-8496397.
TARC showed weak or sporadic reactivity in both LyP and PCALCL, and MIG did not show a distinctive expression pattern in either disorder. Paper-11819891.
In addition, the PTPN22 and insulin variable number tandem repeat genes showed significant associations with T1D or AITD in our families. Paper-13705854.
Although HLA-DRB1 and PTPN22 are well-established susceptibility loci, other genes that confer a modest level of risk have been identified recently. Paper-12484865.
In particular, MCP1-A2518G gave the major contribution as protective locus, similarly to TNF-alpha-C857T, DLG5 rs124869, PTPN22 C1858T variants. Paper-13539430.
CONCLUSIONS: In this large clinical cohort, we replicated the association between HLA-SE and PTPN22, but not CTLA4 with CCP+ and RF+ phenotypes. Paper-12752261.
For each, the SCS-MP2 results are in excellent agreement with the experimental data and compare far more favorably to G3 than both MP2 and B3 LYP. Paper-11431884.
Similarly, the presence or absence of the HLA DRB1 shared epitope or the RA associated PTPN22 allele had no influence on this association. Paper-13539813.
Among candidate genes for type 1 diabetes, HLA, INS, CTLA4, PTPN22 and SUMO4 have been shown to be associated with the disease in Caucasian populations. Paper-13384949.
METHODS: A total of 689 RA patients from the Brigham RA Sequential Study (BRASS) were genotyped for HLA-SE, PTPN22 (rs2476601) and CTLA4 (rs3087243). Paper-12752261.
Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population. Paper-12367742.
Fascin expression in LyP was significantly less frequent than in ALCL (p < 0.001) and also than in LyP associated with lymphomas (p < 0.05). Paper-9297632.
CONCLUSIONS: The data do not support an association between SNPs in PTPN22 and CTLA-4, genes regarded as genetic master switches of autoimmunity. Paper-13595141.
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase ( PTPN22) is associated with rheumatoid arthritis. Paper-10505632.
METHODS: We studied RA risk associated with PTPN22 (rs2476601), PADI-4 (rs2240340), and CTLA-4 (rs3087243) in the Nurses' Health Study (NHS) and NHSII. Paper-13084277.
Recently a number of convincing candidate genes have begun to emerge and an update has been provided for three of these: PTPN22, CTLA-4 and MIF. Paper-11543688.
Currently, 5 loci (HLA, PTPN22, TRAF1/C5, TNFAIP3, and STAT4) have been consistently reported, whereas others have been observed less systematically. Paper-13774036.
Multiplex family-based study in systemic lupus erythematosus: association between the R620W polymorphism of PTPN22 and the FcgammaRIIa ( CD32A) R131 allele. Paper-12308586.
CONCLUSIONS: We confirmed the previously reported association of PTPN22 with RF-positive RA, which was independent from the HLA-DRB1 genotype. Paper-12152312.
Based on significant association evidence, we built an association network among the loci of PTPN22, PADI4, DLG5, SLC22A4, SUMO4, and CARD15. Paper-13461856.
Lack of association between ankylosing spondylitis and a functional polymorphism of PTPN22 proposed as a general susceptibility marker for autoimmunity. Paper-11841744.
The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation. Paper-9197443.
These results implicate PTPN22 in mediating susceptibility to generalized vitiligo and associated autoimmune diseases, but do not support a role for CTLA4. Paper-12827926.
The CD40, CTLA-4, thyroglobulin, TSH receptor, and PTPN22 gene quintet and its contribution to thyroid autoimmunity: back to the future. Paper-13214436.
We conducted a case-control association study for the PTPN22 1858C/T polymorphism in Hungarian and German MG patients (n = 282) and regional controls (n = 379). Paper-13857539.
Sera from the subjects were tested for the presence of antibodies to cyclic citrullinated peptide (anti-CCP), rheumatoid factor (RF), and the 620W PTPN22 allele. Paper-13652278.
However, there was no evidence of association of the confirmed type 1 diabetes susceptibility genes CTLA4 and PTPN22 and the candidate gene IL2RA with IgE levels. Paper-12027066.
RESULTS: SLE patients carrying the risk allele of PTPN22 had higher serum IFNalpha activity than patients lacking the risk allele (P = 0.027). Paper-12987489.
INS, PTPN22, IL2/ IL21, C1QTNF6, and C12orf30, associated with human type 1 diabetes, are contained within the chromosomes 1, 2, 7, and 12 loci. Paper-13694932.
A comparison is made of the relative accuracy of some NDDO semiempirical methods and the DFT functionals LYP and PW91 using both double and triple zeta basis sets. Paper-10446406.
In HLA-DRB1 shared epitope positive, ACPA-positive UA patients, ACPA-levels were significantly increased in PTPN22 1858T allele carriers compared with non-1858T carriers. Paper-13298606.
The PTPN22 1858T variant also increased the risk of autoimmune thyroid disease (AITD) in the RA patients, whereas the FCRL3 risk variant was protective against AITD. Paper-12367742.
Reaction energies for this disproportionation as well as that of the sulfur and tellurium homologues have been calculated with MP2, CCSD(T,) and B3 LYP methods. Paper-11431878.
BACKGROUND: HLA-DRB1 shared epitope (HLA-SE), PTPN22 and CTLA4 alleles are associated with cyclic citrullinated peptide (CCP) and rheumatoid arthritis ( RA). Paper-12752261.
The popular B3 LYP hybrid density functional offers no advantage over the pure PBE functional that at least qualitatively accounts for some of the dispersive effects. Paper-10501922.
PTPN22 has emerged strongly as a genuine rheumatoid arthritis susceptibility gene with replications of the association to the R620W single nucleotide polymorphism. Paper-11365512.
CONCLUSIONS: This is the first study to demonstrate that fascin is expressed in cutaneous CD30+ LPD and that it is a candidate marker of disease progression in LyP. Paper-9297632.
The single nucleotide polymorphism (SNP) C1858T within the PTPN22 gene was recently associated with autoimmune thyroid disease ( AITD) and type I diabetes (T1D). Paper-13603912.
Three additional relevant susceptibility regions mapped on chromosomes 1p13 ( PTPN22), 2q33 ( CTLA-4), and 11p15 ( insulin) have also been described by linkage studies. Paper-13543456.
METHODS: A longitudinally followed cohort of 238 Norwegian patients with RA (the EURIDISS cohort) was genotyped for the PTPN22 1858C-->T polymorphism. Paper-12542971.
We checked for the prevalence of the PTPN22 R620W polymorphism in multiplex families affected with systemic lupus erythematosus ( SLE) and other autoimmune diseases. Paper-12308586.
OBJECTIVE: To investigate whether the PTPN22 1858T risk variant is associated with the rate of radiographic progression in rheumatoid arthritis ( RA). Paper-12542971.
CONCLUSION: Our findings support an association of RA with an FCRL3 functional polymorphism and reveal that this association is stronger in the absence of PTPN22 risk genotypes. Paper-12367742.
Nine genes and ESTs were identified in the contig in addition to a rat EST from the University of Iowa rat EST database-all possible candidate genes for Lyp. Paper-8543439.
CONCLUSION: Most established susceptibility genes seem to act approximately multiplicatively with other loci on the risk of disease except for the joint effect of HLA and PTPN22. Paper-12768771.
BACKGROUND: The PTPN22 gene has been widely confirmed as a susceptibility gene for rheumatoid arthritis ( RA) in populations of Northern European descent. Paper-12687653.
Our comparative study indicated the superiority of MP2 theory while the HF and B3- LYP methods as well as less sophisticated basis sets failed for the correct energetic relations. Paper-8507737.
Consistent interaction, defined as departure from additivity, between HLA-DRB1 SE alleles and the A allele of PTPN22 R620W was seen in all three studies regarding anti-CCP-positive RA. Paper-13183520.
RESULTS: The PTPN22 620W allele frequency was significantly increased in antineutrophil cytoplasmic antibody (ANCA)-positive WG patients compared with healthy controls (P < 0.001). Paper-11506297.
These findings support a genetic heterogeneity across RA populations, suggesting that both the FCRL3 and PTPN22 genes play roles in RA susceptibility, but in different individuals. Paper-12367742.
It is found that SCS-MP2 and the new perturbative B2-PLYP density functional provide accurate reaction barriers and outperform MP2 as well as standard density functionals such as B3- LYP. Paper-11335552.
RESULTS: HLA-SE alleles alone, concomitant presence of TNFRII 196R and PTPN22 1858T alleles, IgA, IgG and IgM RF alone and ACPA were found to be significantly associated with RA diagnosis. Paper-13082028.
This set includes genes involved in cell adhesion ( TNC and SCAM-1), drug metabolism ( cyclooxygenase 1), protein tyrosine kinases and phosphatases ( BTK and PTPN22). Paper-12111608.
PTPN22 polymorphism and anti-cyclic citrullinated peptide antibodies in combination strongly predicts future onset of rheumatoid arthritis and has a specificity of 100% for the disease. Paper-12336974.
We conclude that the common autoimmune polymorphism PTPN22 1858C/T may account for disease susceptibility in a subset of nonthymoma MG patients with anti-titin antibodies present. Paper-13857539.
These findings suggest that the PTPN22 1858T variant alters BCR signaling and implicate B cells in the mechanism by which the PTPN22 1858T variant contributes to autoimmunity. Paper-13651127.
The overlapping clinical and histological features with LyP suggest that both conditions are part of a broader spectrum of primary cutaneous CD30-positive lymphoproliferative disorders. Paper-8018786.
Because the gene confers an impact on autoimmune diseases, we attempt to explore an association between PTPN22 gene and RA in a Japanese population without restricting to the SNP, R620W. Paper-12279563.
OBJECTIVE: To study the association of endometriosis with p53 codon 72 polymorphism in the population of central Italy and to search for possible interaction with the PTPN22 polymorphism. Paper-12892562.
A combination of the PTPN22 1858T variant and anti-CCP antibodies gave a much higher relative risk (>132.03) for developing RA than the combination of the T variant and HLA-SE (OR = 7.85). Paper-12336974.
CONCLUSION: These data demonstrate a novel interaction between the phosphatase Lyp and the adaptor Grb2 and are consistent with a negative regulatory role for Lyp in T-cell signaling. Paper-9197443.
A co-dominant model fitted the rs2476601 (R620W) single-nucleotide polymorphism (SNP) of the PTPN22 gene well, whereas a lack of fit for all models was observed for the HLA-DRB1 locus. Paper-13461867.
We found no evidence of ALK expression nor of Epstein-Barr virus expression in any case either by in situ hybridization or immunohistochemistry in the LyP cases associated with HL. Paper-9297632.
RESULTS: The PTPN22 1858T risk allele was more prevalent in the RA patients (13.9%) compared with the healthy controls (10.3%) (P = 0.008, odds ratio 1.4, 95% confidence interval 1.09-1.79). Paper-12152312.
An interaction between p53 and PTPN22 was observed: a protective action by the Arg/Arg genotype against endometriosis seems to be present only in carriers of the ( *)T allele of PTPN22. Paper-12892562.
Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4. Paper-11451475.
Surprisingly, a previously cloned " lymphocyte-specific" phosphatase, Lyp, was frequently detected in a number of myeloid cell lines as well as normal granulocytes and monocytes. Paper-9791592.
RESULTS: Fascin was expressed by tumor cells in 11/45 (24%) cases of LyP, 11/17 (64%) cases of ALCL, 7/9 (77%) cases of PTL and 6/10 (60%) cases of LyP associated with systemic lymphomas. Paper-9297632.
OBJECTIVE: The C1858T polymorphism in PTPN22 has been associated with the risk of systemic lupus erythematosus ( SLE) as well as multiple other autoimmune diseases. Paper-12987489.
Substantial departure from multiplicativity was observed between smoking and SNPs in genes CTLA4, PADI4, MIF, and SNPs on chromosome 5 and one haplotype of PTPN22. Paper-13461897.
IRF5 is involved in the production of rheumatoid arthritis (RA) cytokines, and SLE already shares with RA one genetic factor within the tyrosine phosphatase PTPN22 gene. Paper-13239152.
A missense single nucleotide polymorphism (SNP) in the PTPN22 gene known as R620W was recently reported to be associated with several autoimmune diseases including rheumatoid arthritis ( RA). Paper-12279563.
The main genetic determinants map to the major histocompatibility complex (MHC), and in particular DR and DQ, although, genes outside the MHC contribute, including the insulin gene, PTPN22, and CTLA-4. Paper-12333552.
We find that "click" chemistry allows cyclic LyP-1 targeting peptides to be specifically linked to azido-nanoparticles and to direct their binding to p32-expressing tumor cells in vitro. Paper-12915334.
PTPN22 ( Lyp), a non-receptor protein-tyrosine phosphatase, is expressed exclusively in cells of hematopoietic origin, notably in T cells where it represses signaling through the T cell receptor. Paper-11807102.
Associations between human leukocyte antigen, PTPN22, CTLA4 genotypes and rheumatoid arthritis phenotypes of autoantibody status, age at diagnosis and erosions in a large cohort study. Paper-12752261.
Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking. Paper-13084277.
Our results support the association of the PTPN22 1858T allele with sporadic childhood-onset SLE in Mexican population.Genes and Immunity (2006) 7, 693-695. doi:10.1038/sj.gene.6364350; published online 26 October 2006. Paper-12347620.
We also found evidence for association (P < 1 x 10(-5)) at FCGR2A, PTPN22 and STAT4, regions previously associated with SLE and other autoimmune diseases, as well as at > or =9 other loci (P < 2 x 10(-7)). Paper-12710316.
Family-based or case-control analyses were done to assess the association of cytotoxic T-lymphocyte-antigen 4 ( CTLA4) and protein tyrosine phosphatase ( PTPN22) variants with susceptibility to multiple sclerosis. Paper-12270145.
Using data from NOD2 and PTPN22, we show that the true sample sizes required to detect association may be incorrect when calculated under the assumption of a single mutation and complete LD with the genotyped marker. Paper-12955747.
The acetylation of tert-butanol with acetic anhydride catalyzed by 4-(dimethylamino)pyridine ( DMAP) has been studied at the Becke3 LYP/6-311 + G(d,p)//Becke3 LYP/6-31G(d) level of theory. Paper-11519397.
The combination of the PTPN22 1858T variant and anti-CCP antibodies gave a high specificity for the disease, and was significantly associated with RA (P = 8.86 x 10(-5), OR 10.05, 95% CI 1.88-53.73). Paper-12701295.
Quantum chemical calculations were carried out for B(N(3))(4)(-), B(N(3))(3), C(5)H(5)N.B(N(3))(3), (N(3))(3)B.NC(4)H(4)N.B(N(3))(3), and the hypothetical C(3)H(3)N(3).[B(N(3))(3)](3) at HF, MP2, and B3- LYP levels of theory. Paper-8809655.
Secondly, in a same and well-defined population, a large genetic association study indicated that a number of polymorphic genes (i.e. HLA-DRB1, TNF and PTPN22) influence the susceptibility for acquiring different ADs. Paper-12349369.
Careful evaluation of the effect of the size of the atomic orbital (AO) basis set shows that the larger expansions improve the agreement with experiment for the SCS-MP2 method, while they get worse for both MP2 and B3 LYP. Paper-11431884.
METHODS: We genotyped 421 nuclear families, 1,331 patients and 1,625 controls for polymorphisms of HLA-DRB1, -DQA1 and -DQB1, the insulin gene ( INS, -23 HphI), CTLA4 (JO27_1) and PTPN22 (Arg620Trp). Paper-12768771.
We genotyped 525 independent North American white individuals with systemic lupus erythematosus ( SLE) for the PTPN22 R620W polymorphism and compared the results with data generated from 1,961 white control individuals. Paper-10480305.
We studied the effect of the INS -23A/T, PTPN22 1858C/T, and CTLA-4 +49A/G polymorphisms on the emergence of T1D-associated autoimmunity in children exposed to cow's milk (CM) based formula during early or late infancy. Paper-13931210.
We observed a statistically significant difference in the frequency of the PTPN22 1858T allele between SLE patients (3.4%) and healthy controls (1.1%) (P=0.0062, odds ratio (OR) 3.09 (95% confidence interval 1.32-7.21)). Paper-12347620.
RESULTS: The PTPN22 1858 minor T-allele frequency was strongly increased in patients with AITD+T1D (23.6%) compared with controls (8.0%, pc<0.001), with patients with AITD only (8.6%, pc=0.006), or with T1D only (10.7%, pc=0.028). Paper-13603912.
Among the major AITD susceptibility genes that have been identified and characterized is the HLA-DR gene locus, as well as non-MHC genes including the CTLA-4, CD40, PTPN22, thyroglobulin, and TSH receptor genes. Paper-13758863.
The more convincing genetic associations include the human leukocyte antigen region (with multiple genes), C1q, PTPN22, PDCD1, Fc receptor-like 3, FcgammaRIIA, FcgammaRIIIA, interferon regulatory factor 5, and others. Paper-12256911.
In humans, genome-wide screens and candidate-gene analyses led to the identification of several loci containing potential targets (FcgammaRIIa, PTPN22, PD-1, IL-10) for physiopathological research and therapeutic interventions. Paper-10789889.
METHODS: Using a protein interaction screening protocol based on phage display, T-cell signaling components that associate with the adapter molecule, Grb2, the lymphoid-specific tyrosine phosphatase Lyp was identified. Paper-9197443.
In this review I touch on three examples of studies that have attempted to understand the mechanisms of genetic susceptibility in three genes identified recently for systemic lupus erythematosus: PDCD1, PTPN22 and IRF5. Paper-12284429.
The SCS-MP2 calculated reaction and activation energies of nine Diels-Alder reactions, four [3,3] sigmatropic rearrangements, and ten electrocyclization reactions are compared to those of the MP2, B3 LYP, QCISD(T), and G3 methods. Paper-11431884.
Testing genetic models of rheumatoid arthritis that include the PTPN22 SNP in addition to the HLA-DRB1 locus did not affect the results, nor did subgroup analysis of PTPN22 conditional on the rheumatoid factor status. Paper-13461867.
In patients with RA, we found no significant interaction between the FCRL3 -169T>C and PTPN22 1858C>T SNPs, nor between the FCRL3 -169CC genotype and IgM-rheumatoid factor or anti-cyclic citrullinated peptide titre levels. Paper-12907492.
CONCLUSION: The autoimmune disease risk allele of PTPN22 is associated with skewing of serum cytokine profiles toward higher IFNalpha activity and lower TNFalpha levels in vivo in patients with SLE. Paper-12987489.
Loci with distinct effects in the two diseases included INS on chromosome 11p15, IL2RA on chromosome 10p15, and PTPN22 on chromosome 1p13 in type 1 diabetes and IL12A on 3q25 and LPP on 3q28 in celiac disease. Paper-13517694.
Lyp was localized to the cytosol, and overexpression of Lyp caused reduction in the phosphorylation levels of multiple proteins in KCL22 chronic myeloid leukemia blast cells including Cbl, Bcr-Abl, Erk1/2, and CrkL. Paper-9791592.
These results suggest that the non-synonymous C1858T substitution in the PTPN22 gene may have an influence on the severity of alopecia areata and provide further evidence for autoimmunity as an aetiological factor in this disorder. Paper-12141064.
The 1858C>T (R620W) functional polymorphism of the PTPN22 gene, which encodes lymphoid protein tyrosine phosphatase ( Lyp), has been associated with susceptibility to a number of autoimmune disorders, including generalized vitiligo. Paper-12791337.
Our results imply that the PTPN22 polymorphism affects the development of T1D-associated autoimmunity only if children are exposed to CM formula during early infancy suggesting an interplay between genetic and environmental factors. Paper-13931210.
We examined single nucleotide polymorphisms ( SNPs) in the PTPN22 and CTLA4 genes in Caucasian patients with BMD to assess the possible association between these polymorphism and the predisposition and clinical expression of this disease. Paper-14161630.
RECENT FINDINGS: The consistent replication of an association between the R620W single nucleotide polymorphism in PTPN22 and rheumatoid arthritis clearly establishes this polymorphism as an important risk factor for rheumatoid arthritis. Paper-11365512.
Our results provide evidence that the PTPN22 1858T allele contributes to risk of generalized vitiligo in European Caucasian populations, and underscores the importance of a genetically mediated autoimmune mechanism in the pathogenesis of vitiligo. Paper-12791337.
We examined single-nucleotide polymorphisms ( SNPs) in the PTPN22 and CTLA4 genes in 126 Caucasian families with multiple cases of generalized vitiligo and associated autoimmune diseases, using a family-based association study design. Paper-12827926.
Given the strong statistical power to replicate a true-positive association in this study, our results provide support for PTPN22, CTLA4, and PADI4 as RA susceptibility genes and demonstrate novel associations with clinically relevant subsets of RA. Paper-11451475.
The objective of this study was to determine whether genetic variants in the loci for interleukin-1 (IL-1), IL-6, IL-10, protein tyrosine phosphatase N22 ( PTPN22), and selenoprotein S are associated with radiographic damage. Paper-13408809.
Nineteen percent of affected individuals had both the PTPN22 T and the CD32A R131 alleles, whereas only 8.5% unaffected relatives had both susceptibility alleles simultaneously [P= 0.031, odds ratios 2.508 (95% confidence interval 1.066-5.896)]. Paper-12308586.
The effect of two monoclonal antibodies P2 ( LyP 2) or P4 ( LyP 4), specific for the platelet membrane glycoprotein IIb/IIIa complex, on binding of 125I-labelled fibrinogen or 125I-labelled fibronectin to thrombin-stimulated platelets was studied. Paper-5149311.
CONCLUSION: The combination of the T variant of the 1858 polymorphism of the PTPN22 gene in combination with the presence of anti-CCP antibodies, preferentially in a SE-positive individual, is associated with the development of RA. Paper-12701295.
To eliminate sources of variance introduced by DNA pooling, the SNPs in the best-ranked PLCG1 as well as the PTPN22 gene were thereafter genotyped in individual MS and control samples, however, without finding evidence for association to MS. Paper-12159497.
CONCLUSIONS: PTPN22 1858T, TNFRII 196R and HLA-SE alleles do not improve the predictive value of RF and ACPA for RA diagnosis in our cohort, and do not contribute to an earlier diagnosis in undifferentiated patients initially negative for RF and ACPA. Paper-13082028.
The PTPN22 1858T allele was associated with the appearance of the autoantibodies and clinical T1D among children exposed to CM formula before the age of 6 months ( PTPN22: for all P <or= 0.001, Log Rank test), but not among children exposed later on. Paper-13931210.
METHODS: The functional protein tyrosine phosphatase type 22 ( PTPN22) SNP (rs2476601, 1858C/T) and CTLA4 SNP (rs231775, 49A/G) were analyzed in 52 patients with BMD and 348 healthy controls by a TaqMan 5' allelic discrimination assay. Paper-14161630.
DISCUSSION: We exclude a major role of *620W in German psoriasis patients but suggest that other susceptibility determinant(s) within non-coding regions of PTPN22 or its proximity might exist acting independently of the major PSORS1 risk factor. Paper-12025493.
OBJECTIVES: To confirm the association of a functional single-nucleotide polymorphism (SNP), C1858T (rs2476601), in the PTPN22 gene of British Caucasian rheumatoid arthritis ( RA) patients and to evaluate its influence on the RA phenotype. Paper-12152312.
Together with recent evidence showing association of this SNP with type 1 diabetes and rheumatoid arthritis, these data provide compelling evidence that PTPN22 plays a fundamental role in regulating the immune system and the development of autoimmunity. Paper-10480305.
Confirmation of the roles of CTLA4 and PTPN22 as general immune function modulators with a nonlinear dose-response effect on autoimmunity, and confirmation of the role of IL2RA, which may act via a regulatory T cell subset on immune disease risk. Paper-12597857.
OBJECTIVE: We examined associations between HLA-SE, PTPN22, CTLA4 genotypes and RA phenotypes in a large cohort to (a) replicate prior associations with CCP status, and (b) determine associations with radiographic erosions and age of diagnosis. Paper-12752261.
To address this, we genotyped DNA from 154 patients with PBC and 166 ethnically matched healthy controls for SNPs of five candidate genes (60G/A CTLA-4, 1858 C/T LYP, -IVS9 C/T foxp3, p1323 C/G ICOS and -9606 T/C CD25) using a TaqMan assay. Paper-11515915.
We detected an association of the PTPN22 1858T allele with MG in the subgroup of nonthymoma patients with anti-titin antibodies present (n = 50; T allele frequency 21% vs 11% in controls; p = 0.005, odds ratio 2.1, 95% confidence interval 1.23-3.58). Paper-13857539.
RESULTS: Susceptibility alleles at loci expected to influence immunoregulation ( PTPN22, CTLA4, and IL2RA) did not differ between progressors and nonprogressors but were elevated in both groups relative to general population frequencies, as was the INS promoter variant. Paper-12921064.
We observed significant association of generalized vitiligo with the 1858T risk allele of PTPN22 [P = 0.0138; OR = 2.92 (1.21-7.03)], with significantly different distribution of PTPN22 1858C>T genotypes in cases versus controls [P = 0.036; OR = 2.69 (1.07-6.80)]. Paper-12791337.
The 620W allele of PTPN22 has been associated with susceptibility to several different forms of chronic inflammatory disease, including Type 1 diabetes (T1D), rheumatoid arthritis ( RA), systemic lupus erythematosus ( SLE), and autoimmune thyroiditis (AIT). Paper-11406071.
The proline-, glutamic acid-, serine- and threonine-rich (PEST) family of protein tyrosine phosphatases (PTPs) includes proline-enriched phosphatase (PEP)/lymphoid tyrosine phosphatase ( LYP), PTP-PEST, and PTP-hematopoietic stem cell fraction (HSCF). Paper-13668182.
Stratification of the RA cohort by PTPN22 genotypes revealed the FCRL3 risk variant and RA association was stronger in the patient subgroup lacking PTPN22 1858T variants (P = 0.004) and was not detectable in the subgroup with PTPN22 1858T variants (P = 0.52). Paper-12367742.
Analysis of the data revealed that allele frequency differences between the different Indian language groups were small, and interestingly the variant alleles of ALOX5 g.8322G>A and g.50778G>A, and PTPN22 g.36677C>T were present only in a subset of the Indian language groups. Paper-12772176.
Incubation of patient (n=100) derived PBMC cells with the autoantigen, the acetylcholine receptor, resulted in a significantly higher number of cells producing anti-AChR antibodies and IL-2 in W620 carriers, suggesting that PTPN22 W620 may be a loss-of-function variant in MG. Paper-12880993.
For this, the allelic distribution of the PTPN22 C1858T alleles was determined in 196 English patients with alopecia areata and 507 healthy subjects in a case control study using a restriction fragment length polymorphism-polymerase chain reaction (PCR-RFLP) genotyping method. Paper-12141064.
The errors for the reaction enthalpies are in general larger than for the barriers when compared to CBS-QB3 literature values, which is related to strong changes in the electronic structures, but the deviations are again smaller than with MP2 or B3- LYP and are also more systematic. Paper-11335552.
The first identified was the Human-Leucocyte-Antigen DR (HLA-DR) gene locus, then a non-HLA genes as cytotoxic T lymphocyte antigen ( CTLA-4), CD40, protein tyrosine phosphatase-22 ( PTPN22), thyroglobulin, and thyroid-stimulating hormone receptor ( TSHR) gene. Paper-13645732.
Furthermore, we analyzed the distribution of CD40 genotypes in subgroups of patients with GD divided according to age of onset, gender, family history, tobacco smoking, ophthalmopathy, and genetic parameters ( CTLA4 49G, PTPN22/ LYP 1858T or HLA-DRB1*03 alleles). Paper-11008145.
The hypersurface for the reaction of H(2)OOH(+) with CH(3)Cl and C(2)H(5)Cl was calculated at the B3 LYP, MP2, and G3(m*) level, underlining the three mechanistic scenarios in which the reaction is either induced by oxidation at the hydrogen or the halogen atom, or by proton transfer. Paper-11426479.
Protein tyrosine phosphatase type 22 ( PTPN22) and Cytotoxic T lymphocyte antigen-4 ( CTLA-4) are two of these genes, and single nucleotide polymorphisms ( SNPs) in the genes encoding these molecules have been associated with several autoimmune diseases. Paper-13595141.
The association of CTLA4 with type 1 diabetes is concentrated in a subset of patients with autoimmune thyroid disease (AITD) in both Japanese and Caucasian populations, while the association of PTPN22 with type 1 diabetes in Japanese and most Asian populations is not as clear as in Caucasians. Paper-12998844.
The identification of such functional variants should provide new clues to the pathogenesis of MG, as recently illustrated by the study of a promoter polymorphism of the CHRNA1 locus, influencing its thymic expression and central tolerance, or of a coding variant of the PTPN22 intracellular phosphatase. Paper-12845869.
ABSTRACT : In the present paper, we used the North American Rheumatoid Arthritis Consortium data provided for Genetic Analysis Workshop 15 Problem 2 to: 1) estimate the penetrances of PTPN22 and HLA-DRB1 and, 2) test the selected model of PTPN22 conditional on the rheumatoid factor status. Paper-13461867.
The genetic factors involved consist of multiple susceptibility genes, at least five of which, HLA, INS, CTLA4, PTPN22 and IL2RA/ CD25, have been shown to be associated with type 1 diabetes in Caucasian (Western) populations, as has recently been confirmed by genome-wide association studies. Paper-12998844.
The minor allele of a single nucleotide polymorphism (SNP) in the PTPN22 gene (1858T) encoding the Lyp-tyrosine phosphatase has been recently associated with multiple autoimmune disorders, raising the possibility that this variant may also represent a risk allele for primary biliary cirrhosis ( PBC). Paper-11839101.
Three other disease susceptibility loci have been clearly demonstrated based on their direct effect on risk, INS ( chromosome 11p15, allelic odds ratio [OR] approximately 1.9), CTLA4 ( chromosome 2q33, allelic OR approximately 1.2), and PTPN22 ( chromosome 1p13, allelic OR approximately 1.7). Paper-11127401.
By comparison of a Danish population sample of 253 Caucasian children and adolescents with T1D and a control group consisted of 354 unrelated healthy blood donors, the present study provides evidence of an isolated association of the disease-associated PTPN22 1858T-allele with T1D to the female sex. Paper-12610006.
Results: Fasting C-peptide levels were significantly lower and HbA1c levels significantly higher in subjects carrying the PTPN22 1858T variant compared with those of subjects homozygous for C1858 from time of disease diagnosis through 12 month of intensive insulin therapy follow-up (p=0.008 and p=0.01 respectively). Paper-12772915.
The distribution of PTPN22 alleles and genotypes among patients and controls was compared, and correlation was sought between PTPN22 'T' and sex, tobacco smoking status, family history of GD, age of disease onset, presence (and severity) of ophthalmopathy, and presence of the CTLA4 A49G or DRB1*03 alleles. Paper-10802291.
METHODS: The functional protein tyrosine phosphatase type 22 ( PTPN22) SNP (R620W rs2476601, 1858C/T), and two CTLA-4 SNPs (rs5742909, -318C/T and rs231775, 49A/G) were analyzed in 140 patients with AAU and 92 healthy controls by sequence-specific primer -polymerase chain reaction (SSP-PCR). Paper-13595141.
In this work, the AFM method has been tested to parametrize force fields for liquid water so that the resulting force fields reproduce forces calculated using the ab initio MP2 and the Kohn-Sham density functional theory with the Becke-Lee-Yang-Parr (BLYP) and Becke three-parameter LYP (B3LYP) exchange correlation functionals. Paper-12972416.
We analysed relationships between the PTPN22 1858 polymorphism and antibodies to cyclic citrullinated peptide (CCP), rheumatoid factors (RFs) and the shared epitope (SE) gene (HLA-DRB1*0404 or 0401) and determined their combined predictive value for rheumatoid arthritis ( RA) in individuals who subsequently developed RA. Paper-12336974.
The aim of this study was to investigate associations of the missense SNP of PTPN22 in a number of autoimmune diseases in the UK population, including RA, juvenile idiopathic arthritis (JIA), psoriasis, psoriatic arthritis (PsA), and multiple sclerosis ( MS), some of which have not been examined previously. Paper-11091329.
To attain tumor-selective tropism, we recently developed a baculovirus vector displaying the lymphatic homing peptide LyP-1, originally identified by ex vivo/in vivo screening of phage display libraries, on the viral envelope by fusion to the transmembrane anchor of vesicular stomatitis virus G-protein. Paper-12975726.
Stratifying patients affected with AITDs according to their phenotype ( Graves' disease and Hashimoto's thyroiditis) and RA patients according to the presence of rheumatoid factor (RF) and antibodies against cyclic citrullinated peptides ( ACPA) did not show any significant association with PTPN22 R620W allele (p>0.05). Paper-13725583.
OBJECTIVE: To analyse the relationship between the presence of auto-antibodies [rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP)], HLA-DRB1 alleles and PTPN22 1858 C/T polymorphism and test the value of their combination as susceptibility markers for rheumatoid arthritis ( RA). Paper-12701295.
Although SNPs in PADI4 had similar allele frequency among three groups [maximal difference 11%; (P >0.05)], the other three loci revealed statistically significant allele frequency differences (maximal difference 39% (P <0.00001), 13% (P <0.00001), and 8% (P <0.00001) in SLC22A4, PDCD1, and PTPN22, respectively). Paper-10752595.
However, inconsistent results of the contributions of non-HLA susceptibility genes have been described, with the exception of a few genes repeatedly associated with RA-susceptibility, such as PTPN22 gene in populations of European ancestry and PADI4 gene in populations of Asian ancestry, revealing the presence of genetic heterogeneity in RA. Paper-13758868.
OBJECTIVE: To analyze the genetic impact of allelic variants of the protein tyrosine phosphatase N22 ( PTPN22) and HLA-DRB1 alleles on IgG autoantibody formation directed toward an immunodominant conformational epitope (C1(III); amino acid residues 359-369) of type II collagen (CII) in early rheumatoid arthritis (RA). Paper-10822342.
METHODS: Because of the association of LyP with HL, fascin expression was analyzed by immunohistochemistry in LyP (n = 45), cutaneous CD30+ ALCL (n = 17) and pleomorphic T-cell lymphoma (n = 9) (PTL) and LyP associated with systemic lymphomas (7 HL, 2 ALCL, 1 MF), with the intent to determine if fascin expression can predict disease progression. Paper-9297632.
RESULTS: We investigated the prevalence of common polymorphisms that have been associated with diseases, such as atherosclerosis ( ALOX5), hypertension ( CYP3A5, AGT, GNB3), diabetes ( CAPN10, TCF7L2, PTPN22), prostate cancer (DG8S737, rs1447295), Hirschsprung disease (RET), and age-related macular degeneration ( CFH, LOC387715). Paper-12772176.
These synonyms are used for gene PTPN22 (protein tyrosine phosphatase, non-receptor type 22 (lymphoid)): Tyrosine-protein phosphatase non-receptor type 22, PTPN8, PEP, LYP2, Lyp2, LYP1, Lyp1, LYP, LyP, Lyp, Lymphoid phosphatase, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP.
These accession numbers are used for gene PTPN22: O95064 (UNIPROT__AC), O95063 (UNIPROT__AC), AK310570 (NCBI_GENBANK__AC), AAD00905 (NCBI_GENBANK__AC).
PTPN22 is a homologue of si:dkey-78k11.1 (si:dkey-78k11.1) from Danio rerio.
PTPN22 is a homologue of PTPN22 (protein tyrosine phosphatase, non-receptor type 22 (lymphoid)) from Bos taurus.
PTPN22 is a homologue of PTPN22 (protein tyrosine phosphatase, non-receptor type 22 (lymphoid)) from Pan troglodytes.
PTPN22 is a homologue of PTPN22 (protein tyrosine phosphatase, non-receptor type 22 (lymphoid)) from Gallus gallus.
PTPN22 is a homologue of PTPN22 (protein tyrosine phosphatase, non-receptor type 22 (lymphoid)) from Canis lupus familiaris.
PTPN22 is a homologue of Ptpn22 (protein tyrosine phosphatase, non-receptor type 22 (lymphoid)) from Mus musculus.
PTPN22 is a homologue of Ptpn22 (protein tyrosine phosphatase, non-receptor type 22 (lymphoid)) from Rattus norvegicus.
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