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In addition, bone matrix showed intensive BMP-3 staining. Paper-8058835.
Initiation of bone development by osteogenin and promotion by growth factors. Paper-6249270.
Osteogenin and related BMPs initiate cartilage and bone formation in vivo. Paper-7378104.
RESULTS: Exogenous rhBMP-2 could promote the expression of BMP-3 in fibroblasts. Paper-9872218.
The expression of BMP-3 in fibroblasts was detected by immunohistochemistry. Paper-9872218.
Induction of bone in composites of osteogenin and porous hydroxyapatite in baboons. Paper-7519772.
Osteogenin initiates new bone formation and is promoted by other growth factors. Paper-7507435.
Surprisingly, BMP-3 and -6 were found in osteoclasts at the sites of bone resorption. Paper-9684218.
However, no bone formation was observed in resorbable rods, even in the presence of osteogenin. Paper-7519772.
Lymphocyte testing was performed to assess development of an immune reaction to osteogenin. Paper-7028919.
The bone inductive protein, osteogenin, was isolated by heparin affinity chromatography. Paper-7507435.
BMP-3 localizes to neural ectoderm and later on in development to newly forming periosteum. Paper-6405100.
Analysis of variance was used to determine effects of bBMP/FS (alpha = 0.05). Paper-12648888.
BMP3 transgenic mice displayed spontaneous rib fractures that were first detected at E17. Paper-13954705.
Expression and possible mechanisms of regulation of BMP3 in rat cranial sutures. Paper-11079857.
Regulation of neural specification from human embryonic stem cells by BMP and FGF. Paper-13966621.
Osteogenin does not impair normal lymphocyte blastogenesis at 6 months postsurgical challenge. Paper-7028919.
Differentiation of bone occurred in nonresorbable hydroxyapatite rods, both osteogenin-treated and controls. Paper-7519772.
RESULTS: Significant bone formation was induced by BMP extract in all treatment groups. Paper-12637436.
Additional defects were implanted with baboon demineralized bone matrix (DBM) or ICBM without osteogenin as control. Paper-7647541.
The remaining two defects were implanted with one disk of each hydroxyapatite preparation without osteogenin as control. Paper-7492831.
Inactivation of BMP pathway genes in the epithelium is known to cause intestinal polyposis. Paper-12740710.
Post-translational modifications of collagen upon BMP-induced osteoblast differentiation. Paper-13293935.
Finally, we observed reduced number of osteoclasts and modulation of genes related to BMP pathways. Paper-12546836.
To optimize BMP-2 secretion, the molecular weight of the polymers and cell densities were varied. Paper-13187116.
Overexpression of BMP3 in the developing skeleton alters endochondral bone formation resulting in spontaneous rib fractures. Paper-13954705.
This study shows BMP3, EYA2, ALX4, and vimentin genes are methylated in most colorectal neoplasms but rarely in normal epithelia. Paper-12646280.
Novel promoter and exon mutations of the BMPR2 gene in Chinese patients with pulmonary arterial hypertension. Paper-13895058.
The sequences were similar to portions of the amino acid sequence deduced from the cDNA clone of bone morphogenetic protein-3 ( BMP-3). Paper-7378104.
Normal rat ventral prostate expressed all these BMP mRNAs, but the rat prostate adenocarcinoma PAIII expressed predominantly BMP 3 mRNA. Paper-8175892.
Further evidence in mice suggests a primary role for mesenchymal loss of BMP signalling in hamartoma development. Paper-12952053.
The expression of BMP proteins in this autocrine loop is essential for Wnt-3A-induced osteoblast differentiation. Paper-10737351.
Sensitive cell lines express the central BMP pathway element SMAD4, whereas the resistant cell lines do not. Paper-12487055.
Osteogenin has been purified to homogeneity from bovine bone matrix and the sequences of several tryptic peptides have been determined. Paper-7378104.
Finally, the use of BMP led to a stable fusion construct within 6 months without encroachment on the spinal canal. Paper-13289517.
Osteogenin (bone morphogenic protein 3) inhibits proliferation and stimulates differentiation of osteoprogenitors in human bone marrow. Paper-8116264.
However, how pluripotential epiblasts temporally and spatially respond to BMP signals to form PGCs remains unclear. Paper-10792081.
The hamartomas that develop in these patients and in BMP pathway mutant mice have a remarkable mesenchymal component. Paper-12952053.
BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Paper-13926085.
Simultaneous addition of 2.5 ng/ml osteogenin and 1,25 dihydroxy vitamin D3 (10(-8) M) enhanced the stimulation observed in osteocalcin synthesis. Paper-8116264.
Sustained BMP Signaling in Osteoblasts Stimulates Bone Formation by Promoting Angiogenesis and Osteoblast Differentiation. Paper-13853722.
Apoptosis at this later stage can be prevented, and BMP-induced regeneration can be further induced by inhibition of p38. Paper-12650170.
Together, these findings indicate that the BMP/Smad signaling pathway has a dominant role in adipocyte lineage determination. Paper-13926085.
Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors. Paper-12485754.
Moreover, functional BMP signaling, demonstrated by the expression of phosphorylated Smad1/5/8, is present in the enteric ganglia. Paper-10802370.
Bmp signaling promotes intermediate mesoderm gene expression in a dose-dependent, cell-autonomous and translation-dependent manner. Paper-11305016.
Osteogenin was isolated from demineralized baboon bone matrix and purified by chromatography on heparin-Sepharose, hydroxyapatite, and Sephacryl S-200. Paper-7464434.
Our study also suggests that BMP antagonists are candidate signaling components that make up the intestinal epithelial stem cell niche. Paper-12485754.
BMP signaling is necessary for neural crest cell migration and ganglion formation in the enteric nervous system. Paper-10802370.
Skin keratinocytes pre-treated with embryonic stem cell-conditioned medium or BMP4 can be directed to an alternative cell lineage. Paper-12484301.
Bone-specific differentiation was observed to occur earlier in the pores of spherical hydroxyapatite implants enhanced with osteogenin within the rabbit socket. Paper-8382694.
Conclusions: The width of residual bone was one of the clinical host factors that affected bone regeneration following BMP implantation. Paper-13815490.
CONCLUSIONS: BMP3 is expressed in rat cranial sutures in a temporal pattern suggesting involvement in cranial suture patency and fusion. Paper-11079857.
These data support a role for modulators of the BMP signaling pathway in treating diseases of iron overload and anemia of chronic disease. Paper-13301937.
By 7d PR, it induces apoptosis by activating p38 (a noncanonical BMP pathway) and down-regulating FGF signaling (by both MAPK and AKT pathways). Paper-12650170.
BMP inhibition also leads to hypoganglionosis and failure of enteric ganglion formation, with crest cells unable to cluster into aggregates. Paper-10802370.
Collagen-targeted BMP3 fusion proteins arrayed on collagen matrices or porous ceramics impregnated with Type I collagen enhance osteogenesis in a rat cranial defect model. Paper-9530379.
A single point mutation of endofin (F872A) disrupts interaction between the catalytic subunit pp1c and sensitizes BMP signaling in vitro. Paper-13853722.
We highlight recent studies suggesting the evolutionary conservation of BMP target gene regulation signaling by Schnurri family zinc finger proteins. Paper-13817698.
Interestingly, Bmp3 was uniquely expressed postnatally in the resting zone of the synchondrosis growth center, suggesting a role in the regulation of cranial base growth. Paper-12331127.
BMP regulates hematopoietic stem cell (HSC) specification during development, while TGF-beta1, 2 and 3 are not essential for the generation of HSCs. Paper-10751970.
We propose that BMP4 is a major gene for AM and/or retinal dystrophy and brain anomalies and may be a candidate gene for myopia and poly/ syndactyly. Paper-12727892.
We provide several lines of evidence to suggest that SMOC acts downstream of the BMP receptor via MAPK-mediated phosphorylation of the Smad linker region. Paper-13872891.
The TGF-beta/ BMP pathway has been associated with the development of diabetic nephropathy, which has some features in common with sickle cell nephropathy. Paper-13114473.
In this study, local bBMP/FS treatment showed a positive trend in improving BMD, histomorphometric parameters, and mechanical strength of osteoporotic vertebra. Paper-12648888.
Induction of initial cardiomyocyte alpha-actin--smooth muscle alpha-actin--in cultured avian pregastrula epiblast: a role for nodal and BMP antagonist. Paper-11154962.
The bone inductive activity, termed osteogenin, can be dissociatively extracted, and it was isolated by heparin affinity, hydroxyapatite and molecular sieve chromatography. Paper-7378104.
These results establish the potential therapeutic application of osteogenin and demineralized bone matrix for the architectural reconstruction of the bone-bone marrow organ in humans. Paper-7647541.
Our results suggest transient activation of Smad signaling pathways in initial MCTP endothelial cell toxicity, and a persistent dysregulation of BMP signaling. Paper-13183237.
Test substances (either simvastatin low- or high dosed or BMP-2) were incorporated into a biodegradable layer of poly(d,l-lactide). Paper-13922729.
Furthermore, BMP3 is regulated in calvarial osteoblasts by recombinant human fibroblast growth factor 2 and by paracrine signaling from dura mater. Paper-11079857.
Histomorphometry on decalcified sections prepared on days 30 and 90 showed superior osteogenesis in osteogenin-treated nonresorbable hydroxyapatite specimens as compared with controls. Paper-7492831.
Inhibition of BMP activity by noggin misexpression within the developing gut, both in ovo and in vitro, inhibits normal migration of enteric neural crest cells. Paper-10802370.
The micro-CT reconstruction analysis showed that the density and connectivity of trabecular bone in bBMP/FS treated vertebrae were higher than those in control groups. Paper-12648888.
The activation of BMP signaling in EBs was confirmed by the increase in the phosphorylation of Smad1/5/8 and by the nuclear localization of phospho-Smad1/5/8 and Smad4. Paper-13806468.
Ankylosis disappearance following application of BMP has been observed in the case of a small defect, which might be beneficial change for periodontal regeneration. Paper-10752635.
We examined approximately 175 haplotype tagging (ht) SNPs in about 70 genes of the TGFbeta/ BMP pathway for their association with GFR using linear regression. Paper-13114473.
These data suggest that although BMP-3 has been isolated from bone matrix, it may have additional regulatory roles in the morphogenesis and/or function of human lung, kidney, and intestine. Paper-8058835.
Simvastatin locally applied from a biodegradable coating of osteosynthetic implants improves fracture healing comparable to BMP-2 application. Paper-13922729.
In situ hybridization and RT-PCR confirmed that these BMP antagonists are expressed by intestinal cryptal myofibroblasts and smooth muscle cells at the colon crypt. Paper-12485754.
Although smooth muscle cell proliferation contributes to the vascular remodeling observed in PAH, the role of BMPs in this process and the impact of BMPR2 mutation remains unclear. Paper-10760560.
We find, however, that Tbx2 expression is neither affected by blocking Shh signaling with cyclopamine nor by genetic removal of several BMP activities in the limb bud. Paper-12459291.
Radiographic results demonstrated progressed callus consolidation in the BMP-2- and simvastatin-treated groups compared to the uncoated group at both timepoints. Paper-13922729.
A lot of reports have studied the presence of BMPs and their effects on bone marker expression in many different cell lines, however none describe the regulation of BMP3 by different factors and expression conditions. Paper-1839863.
Moreover, disruption of the membrane-anchoring FYVE motif by point mutation led to a reduction of BMP-responsive gene expression in cell culture and Xenopus ectodermal explants. Paper-12466233.
Stimulation of osteoblasts with recombinant human fibroblast growth factor 2 led to a rapid and sustained suppression of BMP3 expression (85 percent, p < 0.01) when compared with controls. Paper-11079857.
Our results uncover new functions for TRAF4 as a Smurf1-regulated mediator of BMP and Nodal signaling that are essential for neural crest development and neural plate morphogenesis. Paper-13890046.
We conclude that defective Smad signaling and unopposed p38(MAPK)/ERK signaling, as a consequence of mutation in BMPR2, underlie the abnormal vascular cell proliferation observed in familial PAH. Paper-10760560.
However, each has specific disadvantages. bBMP could rapidly increasing bone formation and suppressing bone resorption, but little is known about its effect on ovariectomized-induced osteoporosis. Paper-12648888.
Our results demonstrate that osteogenin and related BMPs through their profound effects on monocyte recruitment and cytokine synthesis may promote additional successive steps in the endochondral bone formation cascade. Paper-7514717.
Furthermore, adding lefty-1, a nodal antagonist, to the blastoderm inhibited the expression of SMA, and nodal plus BMP antagonist up-regulated the expression of SMA in cultured posterior epiblast. Paper-11154962.
The ability of either sequential Shh and BMP signals or retrovirus-encoded Nkx3.2 or Sox9 to induce this competence correlates with their ability to activate chondrogenesis in various embryonic tissues. Paper-13300732.
RNA interference (RNAi) knockdowns of Smed- BMP or Smed-Smad1 led to the disappearance of dorsal markers along with the ectopic expression of ventral markers on the dorsal side of the treated animals. Paper-12487991.
Northern blot analysis revealed that, the BMP3 mRNA level was increased in a few cell lines (MG-63, HBMSC, HOS) after the addition of 1,25(OH)2D3 when compared to the untreated cells (127%+/-1; 130.5%+/-19.5; 207%+/-14). Paper-1839863.
The current study finds that low and high levels of Bmp ligand are both necessary and sufficient to activate intermediate and lateral mesodermal gene expression, respectively, both in vivo and in vitro. Paper-11305016.
Blocking FGF signaling inhibited neural induction, but did not alter the phosphorylation of the linker region of Smad1, suggesting that FGF enhances human neural specification independently of BMP signaling. Paper-13966621.
These results demonstrate that BMP signaling is activated in all the tissue layers of the GI tract during the development and plays a role during interactions and reciprocal communications of these tissue layers. Paper-11087602.
The collagen-targeted BMP3 fusion protein (rhBMP3-C) was expressed in E. coli, purified from bacterial inclusion bodies, renatured under controlled redox conditions, and assayed for biological activity in vitro and in vivo. Paper-9530379.
The results showed that 10 million transduced fibroblasts that was the maximum number of cells feasible for encapsulation within PEG-DA 10 and 20 kDa hydrogels produced the highest amount of secreted BMP-2 protein. Paper-13187116.
Collectively, these findings reveal that Smad6 serves as a critical mediator of BMP signal via a functional interaction with Tbx6, thus regulating the activation of Tbx6 downstream genes during cell differentiation. Paper-13947977.
In almost all cases, a duplicated central nervous system differentiated dorsally after Smed- BMP or Smed-Smad1 RNAi. These defects were observed not only during regeneration but also in intact non-regenerating animals. Paper-12487991.
Methylation of BMP3, EYA2, ALX4, or vimentin was detected respectively in 66%, 66%, 68%, and 72% of cancers; 74%, 48%, 89%, and 84% of adenomas; and 7%, 5%, 11%, and 11% of normal epithelia (P < 0.01, cancer or adenoma versus normal). Paper-12646280.
Recent progress in the isolation of osteogenin, a specific bone differentiation factor, by heparin affinity chromatography permits the further investigation of the commitment and clonal expansion of the putative osteoprogenitor stem cells. Paper-6249270.
In conclusion, osteoblast targeted expression of a mutant endofin protein lacking the pp1c binding activity results in sustained signaling of the BMP type I receptor, which increases bone formation and skeletal angiogenesis. Paper-13853722.
By in situ hybridization, the BMP-3 transcripts were found in lung bronchial epithelium, straight collecting kidney tubules, intestinal mucosa, perichondrium, periosteum, and osteoblasts of human embryos of 6-14 weeks' gestation. Paper-8058835.
Here we have addressed why inhibition of BMP/Smad1 signaling does not induce neural markers efficiently in Xenopus ventral ectoderm, and show that suppression of both Smad1 and Smad2 signals is sufficient to induce neural markers. Paper-12575012.
In the arterial vasculature, mechanical and inflammatory redox signals, characteristic of hypertension and diabetes have emerged as a secretagogues for BMP production-with downstream activation of endothelial NADPH oxidases (Nox). Paper-12628957.
In each animal, one disk of each hydroxyapatite preparation was treated with osteogenin isolated and purified from baboon bone matrix after sequential chromatography on heparin-Sepharose, hydroxyapatite, and Sephacryl S-200 gel filtration columns. Paper-7492831.
Downregulation of Trb3 inhibits BMP-mediated cellular responses, including osteoblast differentiation of C2C12 cells and maintenance of the smooth muscle phenotype of pulmonary artery smooth muscle cells. Paper-13363249.
In the present study, we use an antibody that recognizes the phosphorylated and activated form of Smad1, 5, and 8 to examine (by immunohistochemistry) the endogenous patterns of BMP signaling pathway activation in the developing GI tract. Paper-11087602.
Using a combination of single-particle electron microscopy, small-angle X-ray scattering, and other biophysical measurements in solution, we show that mTLD, but not BMP-1, forms a calcium-ion-dependent dimer under physiological conditions. Paper-13808010.
Unexpectedly, we found in transfection and localization studies in vitro that both Tbx20 and mutant isoforms of Tbx20 unable to bind DNA attenuate Bmp/Smad-dependent activation of Tbx2 by binding Smad1 and Smad5 and sequestering them from Smad4. Paper-13957585.
Whole-mount in situ hybridization showed that Smed- BMP is expressed at the planarian dorsal midline, suggesting a role in dorsoventral patterning, while Smed-Smad1 is widely expressed throughout the mesenchyme and in the central nervous system. Paper-12487991.
Regulation of BMP3 expression was determined using primary rat calvarial osteoblasts stimulated with recombinant human fibroblast growth factor 2 or recombinant human transforming growth factor beta1, or cultured with primary rat nonsuture dura mater. Paper-11079857.
Even though an increase of mineralized areas among periosteal callus was found at d 42 for simvastatin-high as well as BMP-2 treated animals, no significant difference could be detected at both timepoints compared to the uncoated group. Paper-13922729.
We propose that deregulation of the BMP developmental pathway in a subset of glioblastoma TICs contributes to their tumorigenicity both by desensitizing TICs to normal differentiation cues and by converting otherwise cytostatic signals to proproliferative signals. Paper-12675651.
When a human bone marrow stromal cell (HBMSC) culture was treated simultaneously with 1,25(OH)2D3 (10(-8) M) and BMP3 (2.5 ng/ml), the total osteocalcin content in the cell layer and in the culture medium was higher than when the culture was treated with either factor alone (162%). Paper-1839863.
These data suggest that BMP3 exerts its effects in the skeleton by altering signaling through ActRIIB in chondrocytes and the periosteum, and this results in defects in bone collar formation and late hypertrophic chondrocyte maturation leading to decreased mineralization and less bone. Paper-13954705.
Results indicate that the interaction between the tissues of the posterior epiblast and hypoblast is necessary to initiate the expression of SMA during early cardiogenesis and that nodal and BMP antagonist may play an important role in the regulation of SMA expression. Paper-11154962.
However, BMP antagonists do not inhibit the expression of the "initial heart alpha-actin"--smooth muscle alpha-actin (SMA)--which is first expressed in the anterior lateral mesoderm and then recruited into the initial myofibrils (Nakajima et al. [2002] Dev. Biol. 245:291-303). Paper-11154962.
CONCLUSIONS: Our results suggest that ESC-CM contains a number of factors, including BMP4, which are capable of reprogramming mouse skin keratinocytes to make them more developmentally potent, as evidenced by their ability to be re-differentiated into cells of the neuronal lineage. Paper-12484301.
Manipulations that inhibit both Smad1 and Smad2 pathways, including a truncated type IIB activin receptor, Smad7 and Ski, induce early neural markers and inhibit epidermal genes in ventral ectoderm; and co-expression of BMP inhibitors with a truncated activin/nodal-specific type IB activin receptor leads to efficient neural induction. Paper-12575012.
Osteochondromas of the proximal part of the tibia are benign osteochondral neoplasms or orthotopic lesions of skeletal remodeling associated with dysregulated BMP signaling and have been considered an atypical feature of fibrodysplasia ossificans progressiva, but they may be underdiagnosed because of their often asymptomatic nature. Paper-12723698.
These synonyms are used for gene BMP3 (bone morphogenetic protein 3): Osteogenin, Bone morphogenetic protein 3, BMP-3A, BMP-3.
These accession numbers are used for gene BMP3: Q4VAS5 (UNIPROT__AC), AAH96269 (NCBI_GENBANK__AC), AAA51836 (NCBI_GENBANK__AC), A8MT91 (UNIPROT__AC).
BMP3 is a homologue of zgc:153939 (zgc:153939) from Danio rerio.
BMP3 is a homologue of BMP3 (bone morphogenetic protein 3) from Bos taurus.
BMP3 is a homologue of BMP3 (bone morphogenetic protein 3) from Pan troglodytes.
BMP3 is a homologue of BMP3 (bone morphogenetic protein 3 (osteogenic)) from Gallus gallus.
BMP3 is a homologue of BMP3 (bone morphogenetic protein 3) from Canis lupus familiaris.
BMP3 is a homologue of Bmp3 (bone morphogenetic protein 3) from Mus musculus.
BMP3 is a homologue of Bmp3 (bone morphogenetic protein 3) from Rattus norvegicus.
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