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The anchorless SDH protein, thus, is an important virulence factor. Paper-10973788.
Cochlear microphonics and SDH activity in the hair cells under anoxia. Paper-2517250.
The islet cells in the patient showed a high activity when examined for SDH. Paper-1191612.
After transient ischemia, SDH activity remained unchanged in the CA 1 sector. Paper-621433.
SDH was also sensitive to other anthracycline drugs except for aclarubicin. Paper-9876961.
Therefore, SDH could be a target molecule responsible for CAPS induced toxicity. Paper-10436558.
SDH activities of all types of fibers did not change after hindlimb suspension. Paper-11436874.
In contrast vastus lateralis SDH activity had returned to the pre-training level. Paper-2790939.
The first two enzymes of lysine catabolism are synthesized from a single LKR/ SDH gene. Paper-11365549.
Molecular cloning and tissue distribution of rat sarcosine dehydrogenase. Paper-1657114.
SDH Mutations in Patients Affected by Paraganglioma Syndromes: A Personal Experience. Paper-12313296.
Succinate dehydrogenase ( SDH) deficiency represents a minor cause of Leigh syndrome (LS). Paper-2164535.
CONCLUSION: SDH/E is a significant cause of morbidity and mortality in infancy. Paper-11038275.
Also, 6 potently inhibits SDH in streptozotocin-diabetic rat sciatic nerve. Paper-9041891.
The human sarcosine dehydrogenase gene is at least 75.3 kb long and located on chromosome 9q34. Paper-8343261.
We determined succinate dehydrogenase ( SDH) activity as a marker of energy metabolism in cells. Paper-10555346.
Enzymatic properties of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver. Paper-4855967.
A full-length cDNA for human sarcosine dehydrogenase was isolated from an adult liver cDNA library. Paper-8343261.
The viability of lymphocytes was based on SDH activity that can be measured spectrophotometrically. Paper-8571167.
Also, methoxyacetic acid is a competitive inhibitor of sarcosine dehydrogenase with a Ki of 0.26 mM. Paper-4855967.
Sarcosine is then transformed to glycine by sarcosine dehydrogenase (E.C. number 1.5.99.1). Paper-8724531.
When the SDH method was used, red, tonic, intermediate, and white muscle fibers were easily observed. Paper-4827651.
Succinate dehydrogenase ( SDH) activity of the monocytes was used to determine sublethal concentrations. Paper-10773499.
Succinate dehydrogenase ( SDH) activity decreased by 27% and succinate thiokinase (STH) decreased by 24%. Paper-10658128.
Lactate enhanced the SDH activity under pressure stress (160 mmHg for 3 h) as dose dependent manner. Paper-10555346.
SDH and MAO recoveries in the nuclear and free mitochondrial fractions were increased in these groups. Paper-2297703.
SD-sensitized B cell clones could therefore be triggered by the M7-antigen which shows homology to SD. Paper-6654440.
Bioptically excised samples were processed for copper ferrocyanide preferential SDH cytochemistry. Paper-8944673.
The M1- and M7-antigens are biochemically defined as cardiolipin and sarcosine dehydrogenase, respectively. Paper-7266114.
QP-S, a ubiquinone (Q) protein, accepts electrons from succinate through succinate dehydrogenase ( SDH). Paper-5508829.
COS cells transfected with BPR2 constructs carrying only SCR 1-3 or 1-4 gave similar rosetting behavior. Paper-7856999.
SDH and GPDH activity showed an unusual positive relationship in contrast to the skeletal muscle fiber types. Paper-13062966.
Numbers, cross-sectional areas, or SDH activities of spinal motoneurons did not change after hindlimb suspension. Paper-11436874.
Succinate dehydrogenase ( SDH) was inhibited, and the plasma membrane was compromised just after firing cessation. Paper-9523051.
There were many muscle fibers with reduced levels of succinate dehydrogenase ( SDH) activities in the muscle fiber. Paper-9059616.
SDH was present apically and basally in epithelial cells throughout the epididymis and in the lumen. Paper-11830645.
Only pure nickel suppressed (by 48% compared to Teflon controls) the SDH activity of the HMVECs or THP-1 monocytes. Paper-8349218.
These results indicate that the prevention of the cell surface export of SDH affects the virulence properties of GAS. Paper-10973788.
1. A significant inverse relationship was found between the severity of the hyperplasia and the duration of SDH. Paper-2599648.
The kinetic data suggests that inhibition of SDH by methyl parathion was pH and temperature independent. Paper-4754794.
SDH in all the brain regions shows two high-activity periods, one at 20-35 g and another at 110-220 g body weight. Paper-4199219.
Low succinate dehydrogenase ( SDH) activity in a patient with a hereditary myopathy with paroxysmal myoglobinuria. Paper-6711959.
Coronal sections of the brains were prepared for quantitative imaging of SDH activity and histological examination. Paper-621433.
On the basis of succinate dehydrogenase ( SDH) and myofibrillar ATP-ase activity, 5 types of muscle fibers are described. Paper-4827651.
Plasma membrane damage, SDH inhibition, nucleus shrinkage and impairment of the nuclear border occurred after 2-4 h. Paper-9523051.
Approximately 10% to 15% of paragangliomas are caused by mutations in the succinate dehydrogenase ( SDH) genes B, C, or D. Paper-12836708.
Enzymatic activity and stability of D-fructose dehydrogenase and sarcosine dehydrogenase immobilized onto giant vesicles. Paper-10189311.
Thus, from a phenotypic perspective, succinate dehydrogenase ( SDH) appears to be a well-supported oxygen sensor candidate. Paper-12313300.
Succinate dehydrogenase ( SDH) activity in liver was measured to evaluate the effect of Jat on aerobic glycolysis in liver. Paper-11479227.
Mutations in the genes encoding succinate dehydrogenase ( SDH) have been associated with susceptibility to pheochromocytoma. Paper-12313303.
Work capacity, muscle strength and SDH activity in both legs of hemiparetic patients and patients with Parkinson's disease. Paper-2286801.
In addition, loss of heterozygosity ( LOH) and succinate dehydrogenase ( SDH) enzyme activity assays were performed. Paper-11765040.
The peripheral blood lymphocytes displayed, too, an increase in activity of all the enzymes mentioned except beta-HBDH and SDH. Paper-3557239.
By contrast, positive SDH reactions were observed in tubular cells of the renal cortex but were faint in the sciatic nerve. Paper-9041323.
Thus, light-induced exposure differentially affects SDH activity, cell survival, and growth, depending on cell energy consumption. Paper-10358885.
Mitochondrial volume in liver and pectoral muscle and SDH activity in liver and heart did not alter with life-cycle stage. Paper-12346350.
A number of mutations in human SDH genes are responsible for the development of paragangliomas, cancers of the head and neck region. Paper-10048843.
This neurotoxicity is similar to that of structurally related mitochondrial SDH inhibitors, malonate and 3-nitropropionic acid. Paper-770297.
Effect of age and cold shock on the SDH activity of brain mitochondria and carbohydrate contents of brain of male garden lizard. Paper-3851174.
Anti-mitochondrial antibodies (anti-M7) in heart diseases recognize epitopes on bacterial and mammalian sarcosine dehydrogenase. Paper-6654440.
Cochlear microphonics and succinic dehydrogenase ( SDH) activity of the hair cells during anoxia were studied in guinea pigs. Paper-2517250.
Our data also challenge the dogma that superoxide production by SDH is a flavin-mediated event rather than a quinone-mediated one. Paper-10048843.
Significant differences were found in injury pattern, body weight, and Townsend score between NAHI and SDH/E from other cause. Paper-11038275.
We thus used a specific staining method for succinate dehydrogenase ( SDH), which is located in the membrane system of vital mitochondria. Paper-455300.
The IC(50) of licochalcone A for SDH and NDH in human peripheral blood mononuclear cells were at least 70 times higher than that for FRD. Paper-8991006.
We estimated cell energy consumption by population doubling time, and cell survival and growth by succinate dehydrogenase ( SDH) activity. Paper-10358885.
Primary care physicians are often the first point of contact for patients with seasonal AR ( SAR) or perennial AR (PAR) symptoms. Paper-12774628.
Therefore, these data indicated that streptococci/ SDH-mediated phosphorylation plays a critical role in bacterial entry into the host cell. Paper-1224466.
These cells showed necrotic features such as the swelling of cells, eosin-achromatophilia, the loss of SDH activity and swelling mitochondria. Paper-9893974.
3-Nitropropionic acid (3-NPA) produces hypothermia and inhibits histochemical labeling of succinate dehydrogenase ( SDH) in rat brain. Paper-2016291.
Meanwhile hypospermia, as well as decreased lactate dehydrogenase-x(LDH-x) and succinodehydrogenase ( SDH) in sperm were found in exposed group. Paper-7418565.
The availability of the SDH gene sequence will enable characterization of the genotypes of sarcosinemia patients with different phenotypes. Paper-8343261.
SDH staining suggests that reduced enzyme activity in the midfrequency region of the cochlea occurs acutely following toluene exposure. Paper-8421604.
METHODS: Data from all four trials of fluticasone furoate nasal spray (FFNS) in the treatment of SAR are reviewed and critically considered. Paper-13004858.
When sarcosine is used as the substrate for sarcosine dehydrogenase the kinetics are Michaelis-Menten with a Km of 0.5 mM for sarcosine. Paper-4855967.
We also observed that haloperidol inhibited SDH in the striatum and hippocampus, whereas clozapine inhibited the enzyme only in the striatum. Paper-12620582.
In the control extremity only SDH showed a lowered value on the 3rd post-operative day (p less than 0.05), perhaps due to hypokinesia in hospital. Paper-3949322.
Finally, we looked for evidence of CCH or any other thyroid disease in a panel of germ-line SDH (B or D) mutation carriers and found none. Paper-10991851.
ADM rapidly inactivated mitochondrial SDH during its interaction with horseradish peroxidase (HRP) in the presence of H(2)O(2) (HRP-H(2)O(2)). Paper-9876961.
Cryostat sections of a biopsy from the quadriceps femoris muscle were incubated for succinate dehydrogenase ( SDH) using quantitative histochemistry. Paper-10195178.
Succinate dehydrogenase ( SDH) in central nervous system (CNS) and food muscle (FM) crested at 0400 h while in midgut gland (MG) it was out of phase. Paper-4140696.
OBJECTIVE: Phaeochromocytomas and paragangliomas are familial in up to 25% of cases and can result from succinate dehydrogenase ( SDH) gene mutations. Paper-13012705.
The discovery of the SDH genes in 2000/2001 dramatically changed the genetics of pheochromocytoma (PHEO) and paraganglioma (PGL). Paper-12313290.
SDH was chosen since it is a rate limiting enzyme of the Krebs cycle and therefore it is regarded as a marker for metabolic and neuronal activity. Paper-11660975.
Secoisolariciresinol dehydrogenase ( SDH) catalyzes the NAD(+) dependent enantiospecific conversion of secoisolariciresinol into matairesinol. Paper-11338925.
In this study we report the results of sequencing analysis in leukocyte DNA of patients affected by PHEO/PGL who turned out to be SDH mutation carriers. Paper-12313296.
After 8 weeks of training VO2 max was 19%, vastus lateralis SDH 32%, and cytochrome oxidase activity 35% above the pre-training levels respectively. Paper-2790939.
Therefore, the pseudo-hypoxia pathway in SDH-deficient cells depends on the HIF1alphaprolyl hydroxylase product/substrate ( succinate/alpha-KG) equilibrium. Paper-11526901.
The onset and duration of action of olopatadine hydrochloride nasal spray, 665 mcg (OLO; Patanese), for seasonal AR ( SAR) was evaluated in this study. Paper-12618432.
The intracellular distribution of succinate dehydrogenase ( SDH) activity was measured and mapped in iliotibialis cranialis muscle fibers of growing turkeys. Paper-5130095.
BACKGROUND: Mutations in genes coding for the mitochondrial complex II succinate dehydrogenase ( SDH) subunits cause familial neural crest derived (NCD) tumours. Paper-11519983.
Each week cellular proliferation (hemocytometer), succinic dehydrogenase ( SDH) activity (MTT) and total cellular protein ( bicinchoninic acid) were assessed. Paper-2115774.
The optical density of the SDH stain in brain was reduced according to a similar time-course, most prominently in the cerebellum and least sharply in the thalamus. Paper-2016291.
In aging, energy-deficient sarcomeres are supported to be negatively selected and eliminated, while the surviving ones appear to maintain an adequate SDH activity. Paper-8944673.
Cu, Zn-SOD activity increased by 12.97%-12.11%, the MDA level decreased by 29.12%-39.82% and succinate dehydrogenase ( SDH) activity was ameliorated by 25.15%-34.76%. Paper-11991292.
Comparative histochemical study of the succinic dehydrogenase ( SDH) activity in the respiratory muscles of an air-breathing siluroid fish, Clarias batrachus (Linn.). Paper-2710699.
Altered pH vs. specific activity curves for SDH demonstrated significant inhibition by methyl parathion in buffered acidic, neutral and alkaline ranges. Paper-4754794.
SAR studies revealed that the compounds most likely bind according to binding mode B to the active site, i.e., the 6-phenyl moiety mimicking the steroidal A-ring. Paper-12901787.
The preliminary SAR study suggested the introduction of a chlorine substituent at the 4 position of the benzothiazole ring greatly enhanced the inhibitory activities. Paper-11358032.
Nv, Vv and the average mitochondrial volume (V) were measured on perikaryal Purkinje cell organelles preferentially stained for succinic dehydrogenase ( SDH) activity. Paper-11604657.
We also tested for antibodies against SDH, FAD, and G2s in 12 patients with GH who developed CO (6 patients) or OM (6 patients) after treatment with antithyroid drugs. Paper-9430857.
The caudate nucleus had the greatest density of SDH staining that we measured in brain; it also has been reported to be the region most consistently lesioned by 3-NPA. Paper-2016291.
The succinate dehydrogenase ( SDH) is a mitochondrial enzyme complex with an important role in oxydative phosphorylation and intracellular oxygene sensing and signaling. Paper-10986110.
The initial velocities of SDH in single hepatocytes in sections incubated on gel substrate films are calculated from the activities during the first 20 s of incubation. Paper-281839.
The nucl. of the lateral descending trigeminal tract (dlV) and the nucl. reticularis caloris (rc) showed to moderate SDH activity in the main neuropil and/or perikarya. Paper-5778373.
SDH activity, particularly in the outer hair cells was quite parallel to the oxygen tension in perilymph and also to the behavior of the cochlear microphonics. Paper-2517250.
With respect to different appearances of the SDH staining, minimal essential medium without dextran seems to have a positive effect on the condition of epithelial cells. Paper-455300.
Cytochemical differentiation of muscle fibers by succinic dehydrogenase ( SDH) activity in the respiratory muscles of an air-breathing fish, Channa punctatus (Bloch). Paper-2280204.
Seven days of partial water deprivation did not alter the LDH activity of lizards of all three age groups but caused an increase in SDH activity of old lizards only. Paper-11789622.
In human foetal brain ontogeny the cerebral activity of succinate oxidoreductase (EC 1.3.99.1), i.e. succinate dehydrogenase ( SDH), is higher than the cerebellar activity. Paper-4199219.
Microphotometric assay media for the measurement of succinate dehydrogenase ( SDH) and cytochrome oxidase activities in sections of human skeletal muscle have been developed. Paper-6249786.
We suggest that certain mutations in SDH can make it a significant source of superoxide production in mitochondria, which may contribute directly to disease progression. Paper-10048843.
The measurement is accomplished by transforming creatine to formaldehyde in reactions catalyzed by creatinase ( creatine amidinohydrolase) and sarcosine dehydrogenase. Paper-3734895.
SDH activity in the oriens layer, stratum radiatum and lacunosum molecular layer of the CA 1 sector was lower than in the corresponding layers of the CA 2 and CA 3 sectors. Paper-621433.
This is accomplished by inserting an inverted-repeat sequence targeting the maize LKR/ SDH gene into an intron of a transgene cassette that expresses CordapA. Paper-12661461.
Moreover, our results demonstrated that the atypical antipsychotic olanzapine inhibited SDH in the cerebellum and aripiprazole increased the enzyme in the prefrontal cortex. Paper-12620582.
Finally, the tissue distribution of SarDH was investigated by Northern-blot analysis of total RNA and Western-blot analysis of total protein from several rat tissues. Paper-1657114.
Effects in vitro of methyl parathion on some kinetic constants of succinic dehydrogenase ( SDH) in hepatopancreas of freshwater mussel, L. marginalis were studied. Paper-4754794.
It was concluded that, in poor metabolic control the SDH activity is increased, which counteracts but does not prevent the sorbitol accumulation nor the genesis of complications. Paper-7807698.
The use of nitroblue tetrazolium chloride as a vital stain for SDH activity showed that all mycorrhizal infection revealed by trypan blue staining was not physiologically active. Paper-9149950.
5. Four series of randomized, controlled and double-blind experiments were carried out and consistently showed a lower increase in SDH in NAC-treated animals in each series. Paper-812755.
The findings in our patient suggest a limitation of mitochondrial function, probably related to SDH in the tricarboxylic acid cycle and complex II in the electron transport chain. Paper-6711959.
Mitochondrial function [succinic dehydrogenase ( SDH) activity] and total cellular protein [ bicinchoninic acid ( BCA) assay] were assessed at weekly intervals during metal exposure. Paper-9383397.
From our previous study [Eur. J. Clin. Pharmacol. 56 (2000) 405] we hypothesized that chloramphenicol succinate (CAPS) may be a competitive substrate for succinate dehydrogenase ( SDH). Paper-10436558.
In young rats the reactivity of enzymes investigated is similar in both the tunica media and the intima with the exception of SDH which reacts stronger in the media than in the intima. Paper-11792859.
These cells in the outermost layer give stronger reactions for acidic lipids, phospholipids and cholesterol esters and weaker reactions for SDH and alkaline phosphatase activities. Paper-3466124.
When comparing these groups erythrocyte sorbitol (ERY-SOR) was significantly (P < 0.001) increased in the diabetic patients, but no difference in SDH could be demonstrated. Paper-7807698.
Optimal assay media ( SDH) contained 130 mM succinate, 1.5 mM Nitro Blue tetrazolium, 0.2 mM phenazine methosulphate and 1.0 mM sodium azide in 0.1 m phosphate buffer, pH7. Paper-6249786.
Conversely, some enzymes of the respiratory chain ( SDH, cytochrome oxidase and ATPases) showed a stronger reactivity in the serous cells of the parotid and submandibular glands. Paper-2642474.
After light exposure of the cells, they were processed for analyzing tritium incorporation, succinate dehydrogenase ( SDH) activity, trypan blue exclusion, and DNA fragmentation. Paper-12848180.
Dual presence of SDH and LDH activities in ureter epithelium is seen in hypothetical connection with periods of changing oxygen supply caused by ureter peristalsis. Paper-2370248.
Pyridine-2-aldoxime (25 microM), pyridine-4-aldoxime (15 microM) and L-cysteine (40 microM) neutralized the inhibition of SDH by methyl parathion (12.5 microM). Paper-4754794.
The increased intestinal SDH activity may indicate an elevation in energy assimilation at a time when intestine hypertrophy occurs, thus maximizing BM increase prior to putative migration. Paper-12346350.
The effects ensuing from the interaction between membrane-bound sarcosine dehydrogenase and the surrounding lipids as well as the effects of membrane fluidity were described in this study. Paper-12803983.
Moreover, the fast return to the pre-training level of both SDH and cytochrome oxidase activities indicate a high turnover rate of enzymes in the TCA cycle as well as the respiratory chain. Paper-2790939.
(1) The histochemical staining pattern of succinic dehydrogenase ( SDH) does not show unequivocal differentiation between the type I red and type II red fibres in mammalian striated muscles. Paper-2635661.
Urinary oxalic acid and alkoxyacetic acid excretion together was found to relate to the decrease of the succinate dehydrogenase activity ( SDH) as an indicator of renal mitochondrial effects. Paper-7973179.
The SDH mutation database: an online resource for succinate dehydrogenase sequence variants involved in pheochromocytoma, paraganglioma and mitochondrial complex II deficiency. Paper-11449586.
On the other hand, quail fed 110 ppm, 220 ppm, and 330 ppm monensin in feed for 6 weeks showed a significant rise in SDH and AST activities at 330 ppm but not at 110 ppm and 220 ppm. Paper-6627836.
Recent studies indicate that germ line mutations of genes encoding specific succinate dehydrogenase ( SDH) subunits also predispose individuals to pheochromocytomas and paragangliomas. Paper-12349513.
High levels of SDH activity suggest that kernels synthesize considerable amounts of sorbitol, but the molecular mechanism and functional role for this process have remained equivocal. Paper-12915423.
LKR activity in the bifunctional LKR/ SDH polypeptide is also post-translationally regulated by phosphorylation by casein kinase-2 (CK2), but the consequence of this regulation is still unknown. Paper-11365549.
Two smaller cDNA clones, isolated from adult liver and infant brain libraries, were assembled from the same sarcosine dehydrogenase gene by the use of alternate polyadenylation and splice sites. Paper-8343261.
Pyruvate dehydrogenase complex activity (PDHc) is one of the enzymes known to be reduced, while succinate dehydrogenase activity ( SDH), another enzyme of oxidative glucose metabolism is unchanged. Paper-10237059.
Therefore, we studied SDH activity and the relation with complications and with sorbitol accumulation in erythrocytes from 96 type 1 diabetics and 29 age- and sex-matched healthy subjects. Paper-7807698.
3. The intensity of SDH reaction reveals that except the Adductor mandibularis, Intermandibularis anterior and the Protractor tentaculi all muscles are made up of red as well as white muscle fibers. Paper-2710699.
The standard cast patients had a significant reduction of succinate dehydrogenase ( SDH) activity in the vastus lateralis whereas the patients with the cast brace did not show any significant changes. Paper-3215988.
We conclude that the muscle hypertrophy associated with strength training results in reduced density of regionally distributed mitochondria, as indicated by the reduction in the activity of SDH. Paper-8315312.
In Purkinje cell perikarya, vitamin E deficiency resulted in a significant decrease of Vv, Nv and V, as well as a steeper reduction of the percentage of SDH-positive mitochondria of larger size. Paper-11604657.
The localization of the mitochondria and the relative intensity of succinic dehydrogenase ( SDH) and deoxyribonucleic acid (DNA) activity in the control and BNA-treated trophozoites were compared. Paper-6389688.
Here, we show that alpha-TOS inhibits succinate dehydrogenase ( SDH) activity of complex II (CII) by interacting with the proximal and distal ubiquinone (UbQ)-binding site (Q(P) and Q(D), respectively). Paper-12886296.
In particular, beside its function in the Krebs cycle and the respiratory chain, the specific redox properties of the enzyme could confer to the SDH a specific function in superoxide handling. Paper-9578541.
Regression analysis showed that the change (posttaper minus pretaper) in simulated 40-km endurance time was correlated with the change in CYTOX and SDH activity for all groups combined (r2=0.62-0.72). Paper-10043554.
The Km values determined in situ for SDH in hepatocytes and for LDH in various cell types with the gel film technique are in the same order of magnitude as the corresponding values determined biochemically. Paper-281839.
At the end of experimental period, four animals from each group were perfusion fixed with 4% paraformaldehyde and two animals from each group were used for fresh tissue purposes (for SDH localization). Paper-11020280.
Cross-sectional areas and succinate dehydrogenase ( SDH) activities of soleus muscle fibers and their spinal motoneurons in male Wistar Hannover rats were determined after 16 days of hindlimb suspension. Paper-11436874.
We have shown that in solar keratoses (SK) and in paralesional skin there is instead of an even distribution of succinic dehydrogenase ( SDH) activity a relative decreased activity in the granular cell layer. Paper-3114764.
There were marked increases in the serum activities of AST, ALT, and SDH following carbon tetrachloride administration and all 3 enzymes appeared to be useful markers of acute hepatocellular injury. Paper-5085254.
The absorbances of the formazan reaction products formed by SDH, for example, in sections of liver determined by such means increase linearly during the first minute of incubation, but non-linearly afterwards. Paper-281839.
RESULTS: We confirmed that residual titanate particulates may alter the SDH activity assay, but that this effect is eliminated by adding a final centrifugation step to the standard MTT procedure. Paper-12518472.
This combination of LKR/ SDH silencing and CordapA expression led to the accumulation of free lysine to over 4000 p.p.m. in transgenic corn grain, compared to less than 100 p.p.m. in wild-type controls. Paper-12661461.
The potential at which the activity of SDH becomes attenuated only emerges at saturating substrate conditions and occurs at a potential (ca. + 320mV vs NHE) well removed from any known redox couple in the enzyme. Paper-13037922.
The purity and origin of each peak were assessed by using succinate dehydrogenase ( SDH) activity as the IM marker and reactivities to lipopolysaccharide core and O-antigen monoclonal antibodies as the OM markers. Paper-10039308.
Patients with a hereditary mitochondrial myopathy with succinate dehydrogenase ( SDH) deficiency and abnormal lactacidosis during physical exercise have a low work capacity when exercising for about 10-15 min. Paper-7293975.
Furthermore, some differentiation between fibre types in terms of metabolic properties were present, with type I fibres expressing the highest levels of SDH and lowest levels of alpha-glycerophosphate dehydrogenase. Paper-9924979.
Lethal concentrations (defined as > 50% suppression of mitochondrial succinate dehydrogenase ( SDH) activity) of metals were determined by dose-response curves with the use of 72 h exposures to human THP-1 monocytes. Paper-10547659.
Assessment of auditory function was made using distortion product otoacoustic emissions (DPOAE) with subsequent measurement of succinate dehydrogenase ( SDH) staining density in hair cells using surface preparations. Paper-8421604.
However, within other areas of brain such as subdivisions of the hippocampus, neither endogenous SDH activity nor its sensitivity to inhibition by 3-NPA could predict the susceptibility to neurodegenerative changes. Paper-2016291.
A kinetic study was carried out on the aminolysis of p-nitrophenyl acetate (NPA) by n-decylamine ( DEC), piperazine (PIP) and sarcosine ( SAR) in AOT/ isooctane/water (w/o) microemulsions. Paper-11537481.
A model of the ternary complex of SDH, NAD, and saccharopine identifies residues Lys77 and Glu122 as potentially important for substrate binding and/or catalysis, consistent with a proton shuttle mechanism. Paper-12516424.
Mutations in genes encoding mitochondrial succinate dehydrogenase ( SDH) are frequently involved in the development of neural crest-derived (NCD) tumors, such as pheochromocytomas (PHEOs) or paragangliomas (PGLs). Paper-12313296.
Hypersarcosinaemia is a rare inborn error of metabolism, caused by a deficiency of the sarcosine dehydrogenase complex with tetrahydrofolate as a formaldehyde acceptor needed for the sarcosine-glycine conversion. Paper-3284790.
A thenoyltrifluoroacetone sensitive free radical signal was detected by EPR spectroscopy in succinate-Q reductase reconstituted from this QP-S and SDH; the characteristics of this species identify it as ubisemiquinone. Paper-5508829.
The purpose of this study was to evaluate the responses of succinic dehydrogenase ( SDH) and alkaline phosphatase (ALP) activities of human deciduous teeth pulpal fibroblasts (HDPF) to dental restorative materials. Paper-9416292.
Sarcosine dehydrogenase is a liver mitochondrial matrix flavoenzyme that is defective in patients with sarcosinemia, a rare autosomal metabolic defect characterized by elevated levels of sarcosine in blood and urine. Paper-8343261.
Covalent binding of FAD to SarDH was demonstrated by the observation of strong fluorescence at 530 nm under excitation at 450 nm of the enzyme immunoprecipitated under denaturing conditions from liver extracts. Paper-1657114.
CONTEXT: The identification of mutations in genes encoding peptides of succinate dehydrogenase ( SDH) in pheochromocytoma/ paraganglioma syndromes has necessitated clear elucidation of genotype-phenotype associations. Paper-11374846.
3-Nitropropionic acid (3-NPA), an inhibitor of succinate dehydrogenase ( SDH) at complex II of the mitochondrial electron transport chain induces cellular energy deficit and oxidative stress-related neurotoxicity. Paper-12283880.
A quantitative cytochemical study has been carried out on succinic dehydrogenase ( SDH) activity in biopsy samples of vastus lateralis (VL) and anterior tibialis (AT) muscles from healthy men undergoing orthopaedic surgery. Paper-8944673.
On the basis of his response to folate treatment, a partially-reversible defect in the formation of activated formaldehyde in the reaction catalyzed by sarcosine dehydrogenase was considered to be the most likely site. Paper-4298153.
This study investigated the mode of enantiospecific Podophyllum SDH catalysis, the order of binding, and the stereospecificity of hydride abstraction/transfer from secoisolariciresinol to NAD(+). Paper-11338925.
Thus, weight loss resulted in no change in muscle fiber type or cross-sectional area, but produced increases in capillary/fiber ratio, capillary density, and SDH activity, suggesting an increase in muscle oxidative capacity. Paper-2027719.
Analysis of a subclone containing the resistance gene revealed the presence of the sdhC gene, which encodes the cytochrome b560 subunit of the succinate dehydrogenase ( SDH) complex (Complex II) in the mitochondrial membrane. Paper-10869288.
Intact streptococci and purified SDH induce a similar protein phosphorylation pattern with the de novo tyrosine phosphorylation of a 17-kD protein found in the membrane/particulate fraction of the pharyngeal cells. Paper-1224466.
Succinate dehydrogenase ( SDH); mitochondrial complex II) germline mutations cause CB paragangliomas and there is evidence that the severity and the population genetics of paragangliomas may be influenced by altitude. Paper-12313300.
Ni ion treatment decreases the activity of several Fe-S enzymes related to cellular energy metabolism, including mitochondrial aconitase (m-aconitase), succinate dehydrogen-ase ( SDH), and NADH:ubiquinone oxidoreductase (complex I). Paper-12254613.
The concentrations which caused a 50% decrease in succinic dehydrogenase ( SDH) activity, protein production, and lactate dehydrogenase (LDH) release were measured and compared with these values for fibroblasts and osteoblasts. Paper-538413.
Measurements of succinate-cytochrome c reductase activity in the transformants with mutant sdhC gene(s) suggest that flutolanil resistance of the fungus is caused by a decrease in the affinity of the SDH complex for flutolanil. Paper-10869288.
To clarify the cardiotoxic action of the anthracycline drug adriamycin (ADM), the inhibitory effect on succinate dehydrogenase ( SDH) by ADM and other anthracyclines was examined by using pig heart submitochondrial particles. Paper-9876961.
Ocular allergy associated with SAR and PAR (seasonal and perennial allergic conjunctivitis, respectively) is characterized by both early- and late-phase reactions, with symptoms often persisting long after allergen exposure. Paper-12774628.
When enzyme activity ratios were calculated, sex differences were only evident for the HAD/ SDH ratio (mean +/- SD; females = 0.56 +/- 0.20; males = 0.41 +/- 0.11 and for the PFK/HAD ratio (females = 7.40 +/- 1.6; males = 9.58 +/- 1.9). Paper-4809352.
Cryostat sections (20 microm) of the cervical and lumbar spinal cords of fixed and fresh frozen tissue blocks (n=2/group) were stained for localization of cytochrome oxidase (CO) and succinic dehydrogenase ( SDH) activities, respectively. Paper-11020280.
A proline surfactant including two chiral carbons, sodium N-dodecanoyl-(4R)-hydroxy-L-prolinate ( SDHP), has been synthesized, and its micellization behavior in aqueous solution has been investigated by 1H NMR spectroscopy. Paper-12917789.
First, it was determined whether or not the alloys or pure metals could cause cytotoxicity to THP-1 human monocytes or human microvascular endothelial cells (HMVECs) by measuring the succinic dehydrogenase ( SDH) activity of the cells. Paper-8349218.
Metoprolol tartrate injected intraperitoneally 3 h before and 1 h after carotid ligation (10 mg/kg each dose) significantly decreased the extent of myocardial damage as estimated both with SDH histochemistry and MB-CK serum levels. Paper-6105682.
Samples were sectioned and fibers were analyzed for type (I, IIa, IIb/x), cross-sectional area (CSA), succinate dehydrogenase ( SDH), alpha-glycerol-phosphate dehydrogenase (GPDH), and actomyosin adenosine triphosphatase (qATPase) activities. Paper-9836178.
Dimethylglycine dehydrogenase (EC 1.5.99.2) and sarcosine dehydrogenase (EC 1.5.99.1) are flavoproteins which catalyze the oxidative demethylation of dimethylglycine to sarcosine and sarcosine to glycine, respectively. Paper-4855967.
These findings clearly suggest that SDH plays an important role in cellular communication between streptococci and pharyngeal cells that may be important in host cell gene transcription, and hence in the pathogenesis of streptococcal infection. Paper-1224466.
Ultrastructural transformation of mitochondria in the cotyledons of dry and germinating seeds of Vigna sinensis from the 'orthodox' to 'condensed' forms is coupled with an increasing rise in the specific activity of succinic dehydrogenase ( SDH). Paper-2982142.
After that, the tissues around the sinuatrial nodes were fixed for ultrastructural study; succinate dehydrogenase ( SDH) and Cu, Zn superoxide dismutase (Cu, Zn-SOD) activity, as well as malondialdehyde (MDA) level of the atria were assayed. Paper-11991292.
Histochemical studies revealed a rapid decrease in succinate dehydrogenase ( SDH) staining in IHCs soon after carboplatin treatment, and staining intensity remained depressed in surviving IHCs for at least 1 month after carboplatin treatment. Paper-8319768.
In addition, there is a small increase in the intensity of the HDO resonance over the period of the study, which is interpreted to reflect the ultimate oxidation of the labeled sarcosine methyl group via mitochondrial sarcosine dehydrogenase. Paper-5722987.
Marker enzymes for muscle fibre oxidative ( succinate dehydrogenase SDH) and glycolytic ( glycerophosphate dehydrogenase; alpha-GPDH) capacity was assessed by histochemistry, and the resulting enzyme activities measured by image analysis. Paper-12914860.
In cryostat sections, succinate dehydrogenase ( SDH) activity was mainly found in ciliated cells, whereas neutral lipids and acid-phosphatase-reactive lysosomes were present in all portions of the gill filament, mostly being related to lipofuscin granules. Paper-11101362.
After 24 hours, morphologic and biochemical changes (total protein content, lactate dehydrogenase leakage, neutral red uptake, methathiazole tetrazolium salt metabolization, lysosomal function, and succinate dehydrogenase [ SDH] activity) were investigated. Paper-11814854.
Under spinal anaesthesia, patients underwent a standardised diathermy perianal operation, or had a circumferential doughnut of mucosal prolapse at least 2 cm above the dentate line, using a circular end-to-end stapler (Ethicon Endosurgery SDH 33). Paper-12094857.
Chinchilla cochleae were treated with 3-nitropropionic acid (3-NP, 20 or 50mM), an irreversible inhibitor of succinate dehydrogenase ( SDH), to inhibit the mitochondrial energy production before and after exposure to 75 pairs of impulses at 155dB pSPL. Paper-12721319.
Age changes in the specific activity of cerebral succinic dehydrogenase ( SDH) and the effect of two inhibitors ( malonate and p-chlorophenoxy acetic acid) on enzyme activity were traced in a short-lived species of reptile, Calotes versicolor, the garden lizard. Paper-11789607.
The apparent Km for dehydroepiandrosterone was 0.33 x 10(-6) M. delta4-3-Oxo products of SDH action ( 4-androstene-3,17-dione, app. Ki=0.60x10(-6) M; progesterone, app. Ki=1.5x10(-6) M) were the most potent inhibitors and appeared to act non-competitively. Paper-2439426.
We evaluated the effect of endurance training (cycling 3 times per week for 12 weeks) on succinate dehydrogenase ( SDH) activity in the subsarcolemmal (SS) and intermyofibrillar (IMF) regions of vastus lateralis muscle fibres in 7 individuals (4 females and 3 males). Paper-1362389.
Inherited defects of the mitochondrial succinate dehydrogenase ( SDH) in humans are associated with striking variable clinical presentations ranging from early-onset devastating encephalomyopathy to tumour susceptibility in adulthood, or optic atrophy in the elderly. Paper-9578541.
The NAD-binding domains of TH are homologous to bacterial alanine dehydrogenases (ADH) and eukaryotic saccharopine dehydrogenases ( SDH) as well as N5(carboxyethyl)-L-ornithine synthase of Lactococcus lactis and dipicolinate synthase of Bacillus subtilis. Paper-2057574.
Approximately 60 fibers in each sample were analyzed for their type (I, IIa, or IIx), cross-sectional area (CSA), and succinic dehydrogenase ( SDH), alpha glycerol phosphate dehydrogenase (GPDH) and calcium-activated actomyosin adenosine triphosphatase (qATPase) activities. Paper-8838395.
Thyroidectomy and castration in Calotes versicolor significantly decreased the activities of hepatic mitochondrial cytochrome oxidase, alpha-glycerophosphate dehydrogenase (alpha-GPDH), and succinate dehydrogenase ( SDH) when compared to sham-operated controls. Paper-5818038.
Expressed sequence tags of SDH-like sequences have also been generated from various non-Rosaceae species that do not synthesize sorbitol as a primary photosynthetic product, but the physiological roles of the encoded proteins in non-Rosaceae plants are unknown. Paper-11197717.
The time to 50% fatigue was measured during the training period, and compared with the density of dihydropyridine ( DHP) and ryanodine (Ry) receptors and succinate dehydrogenase ( SDH) and phosphorylase activity determined by histochemical analysis of the swimming muscles. Paper-12781772.
Our analysis also identified a new SDH functional group, which appears to have evolved recently from an ancestral AroE, illustrating a very prominent role of horizontal transmission and neofunctionalizaton in the evolutionary and functional diversification of this enzyme family. Paper-12997172.
Histochemical analysis of five muscles from the water monitor, Varanus s