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Fen1 expression: a novel marker for cell proliferation. Paper-1803296.
FEN1 is Overexpressed in Testis, Lung and Brain Tumors. Paper-13884859.
FEN1 contributes to telomere stability in ALT-positive tumor cells. Paper-13632720.
Here, we analyse the telomeres in human cancer cells following FEN1 depletion. Paper-13632720.
Inhibition of FEN-1 processing by DNA secondary structure at trinucleotide repeats. Paper-2075454.
Essential amino acids for substrate binding and catalysis of human flap endonuclease 1. Paper-536394.
Functional analysis of point mutations in human flap endonuclease-1 active site. Paper-1137914.
Furthermore, Fen1 phosphorylation is detected in vivo and depends upon Cdks activity. Paper-9758086.
Dynamic evidence for metal ion catalysis in the reaction mediated by a flap endonuclease. Paper-9852034.
Active site substitutions delineate distinct classes of eubacterial flap endonuclease. Paper-13604162.
The FEN-1 nuclease family includes several similar enzymes encoded by bacteriophages. Paper-948332.
Processing of an HIV replication intermediate by the human DNA replication enzyme FEN1. Paper-1631361.
Expression of flap endonuclease-1 during meiosis in a basidiomycete, Coprinus cinereus. Paper-10297110.
Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks. Paper-11182768.
Gene expression of flap endonuclease-1 during cell proliferation and differentiation. Paper-8444604.
Functional FEN1 polymorphisms are associated with DNA damage levels and lung cancer risk. Paper-13964996.
FEN1 is a nuclease that plays an important role in DNA replication, repair, and recombination. Paper-13499659.
Triplet repeat expansion generated by DNA slippage is suppressed by human flap endonuclease 1. Paper-10319445.
Defects in yeast FEN1 produce chromosomal instability, hyper-recombination, and sequence duplication. Paper-11128639.
The 3'-flap pocket of human flap endonuclease 1 is critical for substrate binding and catalysis. Paper-13924143.
In this report, the FEN-1 gene expression was examined during cell cycle and differentiation. Paper-1761093.
Analysis of human flap endonuclease 1 mutants reveals a mechanism to prevent triplet repeat expansion. Paper-9668652.
The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors. Paper-11267569.
Overall, the data demonstrate that FEN1 overexpression is common in testis, lung and brain tumors. Paper-13884859.
Given a substrate with the exact HIV nucleotide sequence, FEN1 was able to remove the overlap. Paper-1631361.
Our results suggest that alterations of FEN1 are not likely to contribute to development of lung cancer. Paper-10127747.
Functional analysis of human FEN1 in Saccharomyces cerevisiae and its role in genome stability. Paper-2034787.
Furthermore, Fen1 acetylation was observed in vivo and was enhanced upon UV treatment of human cells. Paper-9007999.
The deoxyribonucleic acid repair protein flap endonuclease-1 modulates estrogen-responsive gene expression. Paper-13299458.
MX, giving apex as a homozygote, is dominant to MF1, giving frenata, which is dominant to the other alleles. Paper-2628650.
The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair. Paper-9579930.
Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300. Paper-9007999.
Acetylation occurs at four lysines located at the C terminus of Fen1, which is important for DNA binding. Paper-9879802.
Wheat ( Triticum vulgare) chloroplast nuclease ChSI exhibits 5' flap structure-specific endonuclease activity. Paper-10625693.
Here, crystals of the complex between the catalytic domain of human FEN1 and a DNA product have been obtained. Paper-12667541.
The FEN-1 family of structure-specific nucleases in eukaryotic DNA replication, recombination and repair. Paper-948332.
Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases. Paper-10774507.
The Fen1 extrahelical 3'-flap pocket is conserved from archaea to human and regulates DNA substrate specificity. Paper-10228064.
A representative MF line, MF1, is resistant to both killing and mutation by MNNG or N-methyl-N-nitrosourea. Paper-5310297.
Similarly, in long-patch base excision repair, a damaged nucleotide is displaced into a flap and removed by FEN1. Paper-10509034.
Thus the substrate specificity of Fen1 has been functionally conserved over a billion years from archaea to human. Paper-10228064.
The replacement of Ser(187) by Ala, eliminating the only phosphorylation site, retains FEN1 in nucleoli. Paper-12832038.
Saccharomyces cerevisiae flap endonuclease 1 uses flap equilibration to maintain triplet repeat stability. Paper-10249128.
Down-regulation of human FEN-1 gene expression during differentiation of promyelocytic leukemia cells. Paper-1761093.
Remarkably, acetylation of the Fen1 C terminus by p300 significantly reduced Fen1's DNA binding and nuclease activity. Paper-9007999.
Functional deficiency of the FEN1 gene has been suggested to cause genomic instability and cancer predisposition. Paper-13303721.
Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria. Paper-12946318.
The influence of adenine nucleotides and Mg2+ on the thermal denaturation of mitochondrial F1-ATPase ( MF1) was analyzed. Paper-1614015.
The aim of the present study was to elucidate the level of expression of FEN1 protein in cancer of testis, lung and brain. Paper-13884859.
Structural changes measured by X-ray scattering from human flap endonuclease-1 complexed with Mg2+ and flap DNA substrate. Paper-1715715.
These data suggested that these sites are the hot spot of mutagenesis in plasmid replicated in FEN-1-deficient cells. Paper-10915828.
In cancer cells, FEN1 deficiency induces gradual shortening of telomeres but does not alter the single-stranded G-overhangs. Paper-13499659.
FEN1 is also important for preservation of telomere stability and thus a key node in maintaining genomic stability. Paper-13884859.
This study investigated whether functional variations in FEN1 gene are associated with DNA damage and lung cancer risk. Paper-13964996.
Although the role Fen1 plays in DNA replication has been well characterized, its function in DNA repair is not so clear. Paper-1803296.
Six DNA samples obtained from non-founding migraine affected members of migraine family 1 ( MF1) were used in this study. Paper-11771754.
In addition, FEN1 was transiently down-regulated in the glioblastoma cell line LN308 by transfection with siRNA. Paper-13884859.
In response to replication arrest, FEN-1 interacts specifically with Werner syndrome protein for efficient fork cleavage. Paper-11182768.
As part of this analysis we discovered and sequenced a FEN1 pseudogene ( GenBank accession #AY249897) located at 1p22. Paper-10127747.
Human flap endonuclease-1: conformational change upon binding to the flap DNA substrate and location of the Mg2+ binding site. Paper-8734638.
The profile of single-site catalysis by TF1 at 23 degrees C was different from that of beef heart mitochondrial F1-ATPase ( MF1). Paper-5465448.
Here we have tested whether one copy of yeast FEN1 is enough to maintain CAG/CTG tract stability in diploid yeast cells. Paper-13182841.
Flap endonuclease 1 efficiently cleaves base excision repair and DNA replication intermediates assembled into nucleosomes. Paper-9255809.
We further demonstrate that FEN1 deficiency in mouse embryonic fibroblasts leads to an increase in telomere end-to-end fusions. Paper-13499659.
Recent genetic evidence indicates that null mutants of the 5'-flap endonuclease ( FEN1) result in an expansion of repetitive sequences. Paper-8461978.
That is, hydroxy pyruvate reductase was detected in only the above-mentioned MF1 strain, but hexulose phosphate synthase (HPS) was not. Paper-12309543.
We show that FEN1 is required for telomere stability in cells that rely on the alternative lengthening of telomere (ALT) mechanism. Paper-13632720.
Arginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determination. Paper-9165434.
FEN1 is a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Paper-10509034.
Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV ( FEN1). Paper-1080015.
After methyl methanesulfonate ( MMS) damage, the mobile fraction of focal GFP- Fen1 decreased and t(m) increased, but it then recovered. Paper-10778354.
Despite sharing significant amino acid sequence homology, the RAD2 proteins exhibit disparate nuclease properties and biological functions. Paper-9376205.
Together the results indicate that the presence of a 3'-flap is the critical feature for efficient hFEN1 substrate recognition and catalysis. Paper-13924143.
The enzyme's active-site structure suggests that DNA binding induces FEN-1 to clamp onto the cleavage junction to form the productive complex. Paper-1598020.
Human FEN-1 can process the 5'-flap DNA of CTG/CAG triplet repeat derived from human genetic diseases by length and sequence dependent manner. Paper-9600289.
In cells with no endogenous defects in DNA repair, exogenous nuclease-defective FEN-1 causes repeat instability and aberrant DNA repair. Paper-9826141.
Selective depletion of either hChlR1 or Fen1 by targeted small interfering RNA treatment results in the precocious separation of sister chromatids. Paper-12935405.
For brain tumors, 9/11 glioblastoma multiforme and 5/8 astrocytomas expressed FEN1 protein at a higher level than did normal brain tissue. Paper-13884859.
Formaldehyde Uptake by Methylobacterium sp. MF1 and Acidomonas Methanolica MB 58 with the Different Formaldehyde Assimilation Pathways. Paper-12309543.
Moreover, a significant increase of FEN-1 protein was observed when temporarily quiescent fibroblasts were induced to proliferate by serum stimulation. Paper-1761093.
This phenotype was observed in an MF1 background but not in a mixed B6/129 background, suggestive of the action of a strain-specific modifying gene(s). Paper-10855243.
Several years ago, we demonstrated that FEN1 migrates into the nucleus in response to DNA damage and under certain cell cycle conditions. Paper-12832038.
The flap endonuclease gene homologue from the hyperthermophilic archaeon, Pyrococcus horikoshii, was overexpressed in Escherichia coli and purified. Paper-1900484.
The Invader assay uses a structure-specific 5' nuclease (or flap endonuclease) to cleave sequence-specific structures in each of two cascading reactions. Paper-8556675.
2. This pseudogene is amplified from cDNA preparations contaminated with genomic DNA and must be taken into account in any FEN1 mutation analysis studies. Paper-10127747.
Results of immunofluorescence and subcellular fractionation studies were also consistent with the presence of FEN1 in the mitochondria of intact cells. Paper-12946318.
Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair. Paper-8953010.
To gain dynamic support for such mechanisms, the role of metal ion cofactors in phosphate diester hydrolysis catalysed by a flap endonuclease has been studied. Paper-9852034.
N-methyl-N'-nitro-N-nitrosoguanidine sensitivity, mutator phenotype and sequence specificity of spontaneous mutagenesis in FEN-1-deficient cells. Paper-10915828.
Cleavage of 5'-flaps by FEN-1 in pre-repair HIV-1 integration intermediates was relatively inefficient and was further decreased 3-fold by HIV-1 integrase. Paper-9319662.
RNAi-mediated silencing of OsGEN-L (OsGEN-like), a new member of the RAD2/XPG nuclease family, causes male sterility by defect of microspore development in rice. Paper-11291586.
The translated sequence is identical to peptide sequence obtained from maturation factor-1, which is 1 of the 10 essential proteins for cell-free DNA replication. Paper-249721.
This antibody has been used to examine Fen1 levels by immunoblotting and its subcellular localization in cultured cells and tissue samples by immunostaining. Paper-1803296.
The Invader technology uses a Flap Endonuclease for allele discrimination and a universal fluorescence resonance energy transfer (FRET) reporter system. Paper-2192782.
Our results suggest that CRN-1/ FEN-1 may play a critical role in switching the state of cells from DNA replication/repair to DNA degradation during apoptosis. Paper-9770814.
FEN1 was retained in protease-treated mitochondria and detected in mitochondrial nucleoids that contain known mitochondrial replication and transcription proteins. Paper-12946318.
When the reaction was initiated by the addition of FEN-1, the cleavage kinetics were dependent on enzyme concentration and appeared to saturate at high concentrations. Paper-675880.
FEN-1 mutations altering PCNA binding should reduce activity during replication, likely causing DNA repeat expansions as seen in some cancers and genetic diseases. Paper-1598020.
Because of their unique structural specificities, FEN-1 and its family members have important roles in DNA replication, repair and, potentially, recombination. Paper-948332.
OBJECTIVES: The aim of this study was to investigate genetic polymorphisms of DNase IV and their relationship with SLE and various autoantibodies present in SLE patients. Paper-12835480.
Our data show a clear overexpression of FEN1 in 19/25 samples from testicular tumors (mostly seminomas) and 4/4 samples from lung tumors (non-small cell lung cancer). Paper-13884859.
These findings suggest that FEN-1 gene expression is inducible during cell proliferation for DNA synthesis, and is down-regulated during cell differentiation. Paper-8444604.
In contrast, antibodies to the MF1 epitope on this microfilarial stage-specific antigen are mostly present in amicrofilaremic donors without clinical lymphatic disease. Paper-369851.
In the current study, we compare the kinetics of these activities to shed light on the aspects of DNA structure and FEN-1 DNA-binding elements that affect substrate cleavage. Paper-11312406.
Here, we demonstrate by immunodepletion experiments that 5'-dRP-N(3) excision in long patch BER of uracil-DNA in a human lymphoid cell extract is, indeed, dependent upon FEN1. Paper-2129016.
Eight restrictively conserved amino acids in FEN-1 have been converted individually to an alanine to elucidate their roles in specific DNA substrate binding and catalysis. Paper-536394.
Indeed, FEN1 depletion resulted in telomere dysfunction, characterized by formation of telomere dysfunction-induced foci (TIFs) and end-to-end fusions in ALT-positive cells. Paper-13632720.
With this approach, we were able to measure continuously the kinetics of DNA cleavage by FEN-1 and to separate experimentally the binding and catalysis functions of the enzyme. Paper-675880.
We have determined the X-ray crystal structure of the Sulfolobus solfataricus PCNA1-PCNA2 heterodimer, bound to a single copy of the flap endonuclease FEN1 at 2.9 A resolution. Paper-12269447.
PowerBLAST and GRAIL analysis of this cosmid sequence identified matches with several other ESTs, the previously described FEN1 gene, and a novel evolutionarily conserved gene. Paper-1495644.
In contrast, the FEN-1 mRNA level showed a sharp decrease in HL-60 cells differentiated by dimethyl-sulfoxide, all-trans retinoic acid or 12-O-tetradecanoylphorbol-13-acetate. Paper-1761093.
In Brugian filariasis, the MF1 epitope is preferentially recognized by residents of endemic areas who remain amicrofilaremic and asymptomatic despite lifelong exposure to filarial worms. Paper-369851.
In the basidiomycete Coprinus cinereus (C. cinereus), which shows a highly synchronous meiotic cell cycle, the meiotic prophase I cells demonstrate flap endonuclease-1 activity. Paper-10297110.
Conversely, most down-regulated were the stress response genes, including several heat shock proteins, yet only the expression of flap endonuclease-1 was significantly decreased in all cell lines. Paper-8823237.
Reverse transcriptase PCR analysis revealed that all 49 lung cancer cell lines (20 small cell lung cancers (SCLCs) and 29 non-small cell lung cancers (NSCLCs)) expressed FEN1. Paper-10127747.
Recently, FEN-1 has been reported to also possess a gap endonuclease (GEN) activity, which is possibly involved in apoptotic DNA fragmentation and the resolution of stalled DNA replication forks. Paper-11312406.
FEN1 protein was abundantly expressed in all 23 lung cancer cell lines (10 SCLCs and 13 NSCLCs) and was expressed at lower levels in three of four normal lung epithelial culture controls. Paper-10127747.
MMR-independent pathways or factors that can process some types of mismatches in DNA are nucleotide-excision repair (NER), some base excision repair (BER) glycosylases, and the flap endonuclease FEN-1. Paper-9416301.
Methylobacterium sp. MF1 (an obligate methylotrophic bacterium isolated newly by the authors) and Acidomonas methanolica MB58 (a facultative methylotrophic bacterium) uptake formaldehyde similarly. Paper-12309543.
In the current paper, we found that FEN1 is superaccumulated in the nucleolus and plays a role in the resolution of stalled DNA replication forks formed at the sites of natural replication fork barriers. Paper-12832038.
The gene expression of FEN-1 was higher in mitotic cells than in resting cells, and was markedly decreased, especially, when terminal differentiation was induced in promyelocytic leukemia cells ( HL-60 cells). Paper-8444604.
Circulating antibodies against one of these peaks, MF1, which contained MBTAA, were observed in male breast cancer patients but not in normal male or male patients with carcinoma of other organs (stomach, colon, lung). Paper-9693856.
Disease-length CAG tracts in Huntington's disease mice heterozygous for FEN-1 display a tendency toward expansions over contractions during intergenerational inheritance compared to those in homozygous wild-type mice. Paper-9826141.
We investigated intramuscular, intravascular, and intraperitoneal delivery of human fetal mesenchymal stem cells (hfMSCs) into embryonic day (E) 14-16 MF1 mice to determine the most appropriate route for systemic delivery. Paper-13177296.
Signal probes corresponding to the cleaved flaps of the primary probes [labeled with fluorescein and 6-carboxytetramethylrhodamine (TAMRA) dye] and Cleavase VIII enzyme (a flap endonuclease) were then added to the mixture. Paper-9022848.
The purified F1-ATPase, which contains three tightly bound nucleotides, denatures at a transition temperature (Tm) of 55 degrees C. The nucleotide and Mg2+ content of MF1 strongly influence the thermal denaturation process. Paper-1614015.
These results demonstrate that the FEN-1 gene expression is up-regulated during entrance into the mitotic cell cycle and down-regulated in nongrowing cells, as in the case of differentiated promyelocytic leukemia cells. Paper-1761093.
Previous structural studies on native T5 5' nuclease, a member of the flap endonuclease family of structure-specific nucleases, demonstrated that this enzyme possesses an unusual helical arch mounted on the enzyme's active site. Paper-9496067.
Very recent structural data obtained from Archaeoglobus fulgidus Fen1 suggest that an extrahelical 3'-flap pocket is responsible for substrate specificity, by binding to the unpaired 3'-flap and by opening and kinking the DNA. Paper-10228064.
Crystallization and preliminary crystallographic analysis of the catalytic domain of human flap endonuclease 1 in complex with a nicked DNA product: use of a DPCS kit for efficient protein-DNA complex crystallization. Paper-12667541.
The decay of fluorescence anisotropy indicated that the rod-shaped probe molecules wobbled in the membranes with a wobbling diffusion constant around 0.1 rad2/nsec, presumably reflecting the dynamics of surrounding lipid chains. Paper-4751053.
More importantly, chromatin immunoprecipitation and RNA interference assays demonstrate that endogenously expressed FEN-1 associates with the native pS2 gene in MCF-7 cells and influences estrogen-responsive gene expression. Paper-13299458.
Together, our studies help to elucidate the functional consequence of the ERalpha- FEN-1 interaction and increase our understanding of the elaborate regulatory mechanisms that drive estrogen-responsive gene expression and DNA repair. Paper-13299458.
Our results identify acetylation as a novel regulatory modification of Fen1 and implicate that p300 is not only a component of the chromatin remodeling machinery but might also play a critical role in regulating DNA metabolic events. Paper-9007999.
The multiple functions of FEN-1 are regulated via several means, including formation of complexes with different protein partners, nuclear localization in response to cell cycle or DNA damage and post-translational modifications. Paper-10774507.
FEN-1 has specific endonuclease activity for repairing nicked double-stranded DNA substrates that have the 5'-end of the nick expanded into a single-stranded tail, and it is involved in processing Okazaki fragments during DNA replication. Paper-1715715.
The crystal structure of Pyrococcus furiosus FEN-1, active-site metal ions, and mutational information indicate interactions for the single- and double-stranded portions of the flap DNA substrate and identify an unusual DNA-binding motif. Paper-1598020.
We have cloned a human FEN-1 gene, overexpressed it in Escherichia coli, purified the recombinant protein to near homogeneity, and characterized its cleavage of a flap DNA structure using a novel analytical approach based on flow cytometry. Paper-675880.
The Invader assay uses a structure-specific flap endonuclease (FEN) to cleave a three-dimensional complex formed by hybridization of allele-specific overlapping oligonucleotides to target DNA containing a single nucleotide polymorphism (SNP) site. Paper-10776598.
FEN-1 recognizes the 5'-flap DNA structure and cleaves it, a specialized endonuclease function essential for the processing of Okazaki fragments during DNA replication and for the repair of 5'-end single-stranded tails from nicked double-stranded DNA substrates. Paper-8734638.
The rate of excision by FEN-1 of 5'-flaps from short- and long-flap oligonucleotide substrates that mimic pre- and post-repair HIV-1 integration intermediates, respectively, and the effect of HIV-1 integrase on these reactions were examined in the present study. Paper-9319662.
FEN1 from the hyperthermophilic archaeon Desulfurococcus amylolyticus was expressed in Escherichia coli, purified and crystallized using the sitting-drop vapour-diffusion method with monoammonium dihydrogen phosphate as the precipitant at pH 8. Paper-13967609.
Using the single-turnover kinetics as a measure of the amount of enzyme-substrate complex present, we estimated the Kd for the FEN-1-flap DNA substrate to be 7.5 nM in the absence of Mg2+ and the rate constant for dissociation of the enzyme-substrate complex to be 0.07 s-1. Paper-675880.
METHODS AND RESULTS: Replacement of glucose, cellobiose and starch in MF1 medium by RB or palm kernel cake and replacement of trypticase peptone and yeast extract in the medium by SM or enzymatic digested soybean milk significantly increased the phytase production by M. jalaludinii. Paper-9238435.
Myelofibrosis in ET, PV and CMGM is graded in no reticulin fibrosis (MFO), early reticulin fibrosis ( MF1), advanced reticulin sclerosis with minor collagen fibrosis (MF2) and advanced collagen fibrosis with or without osteosclerosis (MF3). Paper-1148242.
Myelofibrosis in ET, PV and EMGM is graded into: no reticulin fibrosis (MF0), early reticulin fibrosis ( MF1), advanced reticulin sclerosis with minor or moderate collagen fibrosis (MF2) and advanced collagen fibrosis with osteosclerosis (MF3). Paper-1790449.
The rate of removal of 5'-flaps by FEN-1 from post-repair HIV-1 integration intermediates containing relatively long (7-nucleotide) unpaired 5'-tails and short (1-nucleotide) gaps was increased 3-fold relative to that seen with pre-repair substrates and was further stimulated 5- to 10-fold by HIV-1 integrase. Paper-9319662.
Following the establishment of MF1, the population ofR. flavefaciensslightly increased in the rumen of the four lambs, there was also an increase in straw degradation, in the activity of some glycoside and polysaccharide hydrolases of the adherent microbial populations and in the concentration of acetate in ruminal contents. Paper-12094223.
Site-directed mutagenesis further revealed that a mutation of the KRK cluster to three alanine residues completely blocked the localization of FEN-1 into the nucleus, whereas mutagenesis of the KKK cluster led to a partial defect of nuclear localization in HeLa cells without observable phenotype in yeast. Paper-8953010.
The present data and interpretation are in agreement with those reported recently (Reynafarje and Pedersen, 1996) which show that the first order rate constant of ATP hydrolysis by MF1, the analogous enzyme from mitochondria, is virtually constant under experimental conditions involving either unisite or multisite hydrolysis of ATP. Paper-1865933.
Our data suggest that mutations that arise in FEN1 affect telomere stability and genome fidelity by promoting telomere fusions and anaphase-bridge-breakage cycles, which further drive genome instability and thereby contribute to the transformation process.Oncogene (2009) 28, 1162-1167; doi:10.1038/onc.2008.458; published online 12 January 2009. Paper-13632720.
These enzymes are widely proposed to catalyze phosphate diester hydrolysis using a "two-metal-ion mechanism." Yet, analyses of flap endonuclease (FEN) family members, which occur in all domains of life and act in DNA replication and repair, exemplify controversies regarding the classical two-metal-ion mechanism for phosphate diester hydrolysis. Paper-13031164.
These synonyms are used for gene FEN1 (flap structure-specific endonuclease 1): RAD2, MF1, Maturation factor 1, hFEN-1, Flap structure-specific endonuclease 1, Flap endonuclease 1, FEN-1, DNase IV.
These accession numbers are used for gene FEN1: Q6FHX6 (UNIPROT__AC), CAA54166 (NCBI_GENBANK__AC), B4DWZ4 (UNIPROT__AC), AAM74238 (NCBI_GENBANK__AC).
FEN1 is a homologue of RAD27 (5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment...) from Saccharomyces cerevisiae.
FEN1 is a homologue of PFD0420c (flap exonuclease) from Plasmodium falciparum 3D7.
FEN1 is a homologue of Os05g0540100 (Os05g0540100) from Oryza sativa Japonica Group.
FEN1 is a homologue of NCU02288.1 (hypothetical protein) from Neurospora crassa OR74A.
FEN1 is a homologue of MGG_06559 (similar to NADPH oxidase isoform 2) from Magnaporthe grisea 70-15.
FEN1 is a homologue of KLLA0F02992g (hypothetical protein) from Kluyveromyces lactis NRRL Y-1140.
FEN1 is a homologue of FEN1 (flap structure-specific endonuclease 1) from Bos taurus.
FEN1 is a homologue of FEN1 (flap structure-specific endonuclease 1) from Pan troglodytes.
FEN1 is a homologue of FEN1 (flap structure-specific endonuclease 1) from Gallus gallus.
FEN1 is a homologue of FEN1 (flap structure-specific endonuclease 1) from Canis lupus familiaris.
FEN1 is a homologue of Fen1 (flap structure specific endonuclease 1) from Mus musculus.
FEN1 is a homologue of Fen1 (Flap endonuclease 1) from Drosophila melanogaster.
FEN1 is a homologue of Fen1 (flap structure-specific endonuclease 1) from Rattus norvegicus.
FEN1 is a homologue of fen1 (FEN-1 endonuclease) from Schizosaccharomyces pombe.
FEN1 is a homologue of crn-1 (Cell-death-Related Nuclease) from Caenorhabditis elegans.
FEN1 is a homologue of AT5G26680 (endonuclease, putative) from Arabidopsis thaliana.
FEN1 is a homologue of AgaP_AGAP011448 (AGAP011448-PA) from Anopheles gambiae str. PEST.
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