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GIP, incretin and gastrointestinal disease. Paper-4520152.
GIP levels are highly elevated in CAPD patients. Paper-4834251.
GIP effects on cell proliferation are not known. Paper-9926964.
GIP and DIP: a new view of uraemic toxicity. Paper-7961251.
GIP receptors and signal-transduction mechanisms. Paper-735828.
This suggests an insensitivity of the diabetic B-cell to GIP. Paper-81558.
GIP effects on gastric emptying have not yet been studied. Paper-10383687.
Glucose-induced GIP levels in patients with insulinoma. Paper-4530817.
In addition, GIP seems to have direct effects on lipid metabolism. Paper-3993216.
The human GIP gene has been assigned to chromosome 17q21.3----q22. Paper-6370745.
Circadian rhythm of gastric inhibitory polypeptide ( GIP) in man. Paper-4517100.
A reduced GIP response has been seen in patients with celiac disease. Paper-3274254.
Gastric inhibitory polypeptide links overnutrition to obesity. Paper-9849864.
Gastric inhibitory polypeptide in obesity and diabetes mellitus. Paper-4542130.
Influence of vagotomy upon GIP release in patients with peptic ulcer. Paper-4548694.
Secretion of GIP in responders to acarbose in obese Type 2(NIDDM) patients. Paper-8937987.
Capillary and venous blood was drawn for glucose, insulin, C-peptide, and GIP. Paper-10939630.
Both doses of rioprostil delay and reduce the 3-h postprandial GIP release. Paper-6167311.
The infusion of GIP increased plasma cortisol levels to 7.8 times above baseline. Paper-663509.
GIP is released from the precursor by processing at single arginine residues. Paper-5724381.
CONCLUSIONS--We conclude that glyburide enhances beta-cell sensitivity to GIP. Paper-7567602.
Gastric inhibitory polypeptide, dietary-induced thermogenesis, and obesity. Paper-5515439.
No effect of gliclazide on gastric inhibitory polypeptide ( GIP) in type II diabetes. Paper-5624953.
We present the first case of food- and GIP-dependent adrenal adenoma in an adolescent. Paper-10680127.
Plasma concentrations of GIP tended to be higher during nadolol than placebo treatment. Paper-5112388.
In gastrointestinal diseases accompanied by malabsorption the GIP response is diminished. Paper-3649107.
Concomitantly, GIP (10(-10) - 10(-6) M) increases the basal cyclic AMP level in the cells. Paper-4532036.
GIP was raised after glucose and triglyceride more than after protein (P = 0.0003). Paper-7401765.
GIP synthesis has now been documented in the dentate gyrus of the hippocampus. Paper-12284179.
The kinetics of the hydrolysis of GIP, GLP-1(7-36)amide and PHM were analyzed in detail. Paper-93992.
Finally, ANTGIP reversed the effects of GIP on both basal and stimulated adipocyte metabolism. Paper-12170766.
After sucrose ingestion, plasma levels of GIP peaked at 15 min and remained high up to 120 min. Paper-59336.
Concentrations of GIP (p < 0.001) were higher in the amniotic fluid than the fetal circulation. Paper-235063.
Our data show that the insulinotropic effect of GIP is almost abolished in insulinoma patients. Paper-4530817.
Synthesis of a 42 residue peptide corresponding to the entire amino acid sequence of human GIP. Paper-4855097.
Glucose-dependent insulinotropic polypeptide induced growth hormone secretion in acromegaly. Paper-10172995.
Therefore, GIP abnormalities occur in a large number of gastrointestinal and metabolic diseases. Paper-4247428.
Enteroglucagon and GIP after oral glucose in patients with prolactinoma and acromegaly. Paper-4517340.
GIP is produced by K cells, a specific subtype of small intestinal enteroendocrine (EE) cell. Paper-10805830.
Giant cell interstitial pneumonia ( GIP) is a very uncommon respiratory disease. Paper-9590158.
GIP and insulin responses to oral glucose in coeliac patients before and after treatment. Paper-11979691.
GIP is a peptide secreted by the duodenal K-cells in response to ingested fat and carbohydrate. Paper-10534247.
CONCLUSIONS/SIGNIFICANCE: This study shows that vaccination against GIP was safe and effective. Paper-12991208.
Gastric inhibitory polypeptide response to hyper- and hypoglycemia in insulin-dependent diabetics. Paper-3187069.
The GIP binding sites of human insulinoma were coupled to adenylate cyclase stimulation. Paper-5566628.
In this study we report the presence of insulin and GIP in human AF of normal and diabetic pregnancies. Paper-5066320.
In the present study, we identified a novel role for GIP in regulating K(V)1.4 channel endocytosis. Paper-10784581.
GIP acts on the B-cells of the pancreas by potentiating glucose-induced insulin secretion. Paper-3649107.
Similarly, hyperinsulinism and hypoglycemia failed to suppress baseline GIP levels in the diabetics. Paper-3187069.
Complementary DNA clones encoding human GIP were isolated from a library prepared with RNA from duodenum. Paper-5724381.
In the current study we demonstrate a role for arachidonic acid in GIP-mediated signal transduction. Paper-8996926.
Pepsin output in the tests with and without GIP did not differ significantly at any dose of pentagastrin. Paper-3534520.
Insulin and glucose-dependent insulinotropic polypeptide levels were not associated with FSR periodicity. Paper-351426.
In many of these patients, newly described granulocyte inhibitory proteins ( GIP) can be demonstrated. Paper-488629.
Two missense SNPs in GIP showed significant effects with palmitoleic and stearic fatty-acid concentration. Paper-12634859.
Incubation of adenomatous cells prepared from this tumor with GIP resulted in increased cortisol secretion. Paper-10680127.
Arachidonic acid is therefore a new component of GIP-mediated signal transduction in the beta-cell. Paper-8996926.
To our knowledge this is the first physiological characterization of receptors for GIP in endothelial cells. Paper-8618289.
The response of gastric inhibitory polypeptide ( GIP) and insulin to glucose in duodenal ulcer patients. Paper-2949530.
Glucose-dependent insulinotropic polypeptide modulates adipocyte lipolysis and reesterification. Paper-12170766.
Epinephrine alone and epinephrine + phentolamine did not influence glucose-stimulated GIP. Paper-3985345.
A randomized trial comparing GIP to a two-drug combination of gemcitabine and cisplatin is planned. Paper-8631612.
Stimulation of HCO3- transport by gastric inhibitory peptide ( GIP) in proximal duodenum of the bullfrog. Paper-3457851.
There appears to be no direct effect of the autonomic nervous system on glucose-induced secretion of GIP. Paper-5184771.
Cultured subcutaneous human adipocytes showed similar responses to GIP but with greater sensitivity. Paper-12459872.
On the other hand, GIP seems to have direct metabolic effects independent of its insulinotropic activity. Paper-4849116.
In contrast, after 1 month of treatment with tolazamide, IR- GIP concentrations were not significantly altered. Paper-3717407.
Betazole, a pyrazole analogue of histamine, as well as pentagastrin and HCl stimulate GIP secretion. Paper-4015783.
Gastric inhibitory polypeptide hypersecretion in diabetes mellitus: effect of sulfonylurea treatment. Paper-3717407.
Electronimmunocytochemical evidence for the K cell localization of gastric inhibitory polypeptide ( GIP) in man. Paper-3155912.
Mature Sertoli cells were observed in testicular biopsies performed in three patients with untreated GIPP. Paper-7597881.
Bombesin-like peptides produced by enteric neurons and luminal nutrients stimulate GIP release in vivo. Paper-10805830.
The data suggests that postprandial insulin and GIP responses are key players in short-term appetite regulation. Paper-8919186.
Consumption of 7.5 and 15% Fructose diets increased fasting plasma glucose and GIP responses in both groups. Paper-4522003.
Functional GIP receptors in a hamster pancreatic beta cell line, In 111: specific binding and biological effects. Paper-4532036.
Plasma glucose, insulin, GIP, NEFA and ketone concentrations were also very similar following the two meals. Paper-8091728.
24-hour profiles of melatonin, cortisol, insulin, C-peptide and GIP following a meal and subsequent fasting. Paper-3981399.
Chemical modifications of the cysteine residues also have little influence on the antigrowth activity of the GIP. Paper-10193662.
Pancreastatin inhibited carbachol- but not forskolin- or GIP-stimulated insulin release from Rin m 5F cells. Paper-6268756.
The human gene coding for the human GIP precursor spans approximately 10 kilobase pairs and consists of six exons. Paper-6370745.
Twenty-two vagotomized peptic ulcer patients were studied on the influence of vagotomy on the release of GIP. Paper-4548694.
We report that there are differences in GIP activation of the signal transduction pathways in these two cell types. Paper-10222191.
Clinical endocrinology and metabolism. Glucose-dependent insulinotropic polypeptide/gastric inhibitory polypeptide. Paper-10628667.
We report that GIP dose dependently stimulated 3H-thymidine incorporation in the osteoblastic-like cell line MG-63. Paper-9926964.
The secretion of GIP, a 42 amino acid polypeptide secreted by duodenal K cells, is triggered by fat and glucose. Paper-502789.
The GIP moiety is flanked by polypeptide segments of 51 and 60 amino acids at its NH2 and COOH termini, respectively. Paper-5724381.
To a lesser degree, gastric acid secretion, gastric emptying and vagal control may also influence GIP secretion. Paper-3971422.
There is, however, clear evidence for an association between post-prandial GIP concentrations and triglyceride levels. Paper-1249612.
Specific binding sites for GIP have been characterized in a insulin-secreting pancreatic tumor cell line, In 111. Paper-4532036.
GIP immunoreactive cells were observed in the pancreas of five foetuses with gestational ages of 18-20 weeks. Paper-3987733.
Interestingly, the GIP promoter activity was repressed by the c-jun proto-oncogene product, possibly through the CREs. Paper-7571970.
In conclusion, plasma cortisol responsiveness to LVP, GIP, and octreotide is heterogeneous in patients with AIMAH. Paper-1345477.
GIP infusion in dogs results in an increase in portal vein circulation but a drop in hepatic artery blood flow. Paper-10222191.
We have demonstrated the possibility that GIP stimulates GH secretions from the pituitary adenoma cells of acromegalics. Paper-10172995.
Preceding hyperinsulinemia prevents demonstration of insulin effect on fat-induced gastric inhibitory polypeptide ( GIP). Paper-4541933.
We conclude that GIP does not inhibit pentagastrin-stimulated gastric acid secretion in vagotomized human subjects. Paper-3932513.
Total plasma cholesterol, insulin and glucose-dependent insulinotropic polypeptide were also measured at each timepoint. Paper-351426.
McCune-Albright syndrome (MAS) in girls is characterized by gonadotropin independent precocious puberty ( GIPP). Paper-11616933.
Thus, in juvenile obesity, excessive alimentary beta-cell stimulation may be independent of the increased release of GIP. Paper-8464271.
Taken together, these findings implicate the possible role of GIP as a neuromodulator in the central nervous system. Paper-11772281.
Reversal of impaired GIP and insulin secretion in patients with pancreatogenic steatorrhea following enzyme substitution. Paper-3701422.
The pharmacokinetics of porcine glucose-dependent insulinotropic polypeptide were investigated in six healthy volunteers. Paper-4228444.
High-carbohydrate, low-fat diet: effect on lipid and carbohydrate metabolism, GIP and insulin secretion in diabetics. Paper-4836318.
The in vitro secretory response to GIP was higher for the adrenal androgen DHEA, compared with cortisol. Paper-8676525.
Insulin and GIP levels were however, not suppressed to control values after atropine administration in obese patients. Paper-5199067.
Factors other than GIP seem to be of greater importance in determining the magnitude of B cell function in Type 1 diabetes. Paper-4817169.
Here we report the heterologous expression of GIP as a histidine-tagged fusion protein in Escherichia coli cells. Paper-9144773.
Augmentation of alimentary insulin secretion despite similar gastric inhibitory peptide ( GIP) responses in juvenile obesity. Paper-8464271.
GIP hypersecretion in turn might play a role in the pathogenesis of hyperinsulinemia that characterizes acromegaly. Paper-8994316.
The complete GIP cDNA clone has 1315 nucleotides with a 372-base open reading frame encoding a 124-amino acids protein. Paper-8692269.
Thus, in food-dependent Cushing's syndrome the adrenals aberrantly express receptors for gastric inhibitory polypeptide ( GIP). Paper-2171872.
The incretin effect of the patients with less than 150 cm jejunum was significantly subnormal in spite of a normal GIP release. Paper-3449790.
The present data represents the first analysis of functionally relevant GIP binding sites in a insulin-secreting cell. Paper-4909846.
We also isolated 94 probe sets potentially linked to the formation of GIP-dependent nodules adjacent to the diffuse hyperplasia. Paper-12216273.
The predicted amino acid sequence indicates that GIP is derived by proteolytic processing of a 153-residue precursor, preproGIP. Paper-5724381.
Reduction of the GIP-protein complex by 100 mM dithiothreitol induces a decrease of the electrophoretic mobility of the complex. Paper-5188283.
Even though GIP has insulinotropic action, its role in the hyperinsulinism found in hyperthyroid subjects appears to be minimal. Paper-4849000.
The interaction of GIP with its receptors in the hamster pancreatic insulin-secreting beta cell line, In lll, has been analyzed. Paper-4909846.
Elevated plasma glucose-dependent insulinotropic polypeptide associates with hyperinsulinemia in impaired glucose tolerance. Paper-10464072.
The Mr 64,000 complex is not observed in tissues which have no specific binding sites for GIP such as intestinal epithelium. Paper-4776708.
During the application of SMS 201-995 hypoglycaemia did not develop and plasma insulin and GIP concentrations remained unchanged. Paper-6247922.
Following oral glucose, morphine slowed gastric emptying and reduced plasma concentrations of glucose, insulin, and GIP. Paper-5167492.
The effect of dietary modification and hyperglycaemia on gastric emptying and gastric inhibitory polypeptide ( GIP) secretion. Paper-5916235.
Our data suggest the contribution of altered GIP secretion in the pathogenesis of hyperinsulinemia in essential hypertension. Paper-242220.
CONCLUSION: This study provides evidence that in patients with acromegaly fasting and postprandial GIP levels are abnormally high. Paper-8994316.
The results suggest that betazole and therefore histamine may stimulate GIP directly and not necessarily via the mediation of HCl. Paper-4015783.
In the clonal pancreatic beta-cell line, BRIN-BD11, GIP(1-16) demonstrated weak insulin releasing activity compared with native GIP. Paper-9624672.
An inverse correlation was observed between AUC(incremental, GIP) and energy intake at the subsequent ad libitum meal in all groups. Paper-8919186.
Nocloprost was without effect on gastric inhibitory polypeptide ( GIP) and did not influence insulin or C-peptide concentrations. Paper-6179692.
The higher serum GIP concentrations observed following glucose ingestion in diabetics could not be attributed to obesity or age. Paper-2507187.
Remarkably, high glucose leads to an increase in the same intracellular signals, as does a combination of acetylcholine and GIP. Paper-12669.
We conclude that food-dependent Cushing's syndrome results from the expression of GIP receptors on adrenocortical adenoma cells. Paper-663509.
In contrast, the GIP response to the test meal was blunted after dexamethasone (126 +/- 17 vs. 177 +/- 23 pmol/l; p less than 0.001). Paper-5519300.
The magnitude of the increase in plasma GIP after oral glucose load was positively correlated to the length of residual jejunum. Paper-3449790.
The influence of body weight, age and glucose tolerance on the relationship between GIP secretion and beta-cell function in man. Paper-6275182.
Concentrations of gastric inhibitory polypeptide ( GIP) in fetal blood were higher than levels in maternal blood but not significantly. Paper-235063.
Maximum acid output in response to tetragastrin correlated significantly with integrated GIP response after oral glucose loading. Paper-4548694.
It is concluded that GIP secretion is stimulated by glucose absorption and tGLP-1 secretion by the presence of sucrose in the gut. Paper-59336.
Glucose-dependent insulinotropic polypeptide enhances adipocyte development and glucose uptake in part through Akt activation. Paper-12630473.
Although the presence of gastric inhibitory polypeptide ( GIP) in amniotic fluid has not been described, it is present in the fetal gut. Paper-5066320.
Of the 746 diverse cases in the authors' analytical database, almost all cases with the highest tungsten concentration showed GIP. Paper-12885516.
Cyclic AMP production and insulin releasing activity of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide. Paper-9624672.
Following incubation in plasma, (Ser2)GIP had a reduced hydrolysis rate compared with native GIP, while (Gly2)GIP was completely stable. Paper-9707514.
Cell suspensions of adrenal tissue from the patient produced more cortisol when stimulated by GIP than when stimulated by corticotropin. Paper-7259932.
Apathetic behaviour and consciousness disorders were measured with the Behaviour Rating Scale for Psychogeriatric Inpatients ( GIP). Paper-11236702.
There were no significant effects of administration of GIP or triglyceride on the blood levels of glucose or immunoreactive insulin. Paper-6865271.
Lack of a direct effect of the autonomic nervous system on glucose-stimulated gastric inhibitory polypeptide ( GIP) secretion in man. Paper-5184771.
Total integrated GIP (P < 0.05) and glucose (P < 0.01) responses were higher post heparin than after acipimox in obese subjects only. Paper-1812126.
The total area under the curve ( AUC) of the GIP response after the mixed meal was associated with insulin sensitivity (r = 0.54, P < 0.01). Paper-10710576.
Postpartum, the GIP response was greater in the gestational diabetics than in normal women whereas no difference was found in pregnancy. Paper-4758298.
RESULTS: The peak level of glucose and peak levels and area under the curve ( AUC) of insulin and GIP were higher in patients (P < 0.05). Paper-1079757.
A role for GIP in the regulation of lipid homeostasis and in the development of obesity has been inferred from different animal studies. Paper-10628667.
PATIENTS: Ten patients, who met the criteria for dementia ( DSM-IV) and motor restless behaviour (subscale 10 of the GIP), were included. Paper-8704150.
Characterization of the cellular and metabolic effects of a novel enzyme-resistant antagonist of glucose-dependent insulinotropic polypeptide. Paper-9365245.
Glucose-dependent insulinotropic peptide ( GIP) is a 42-amino acid peptide synthesized and secreted from endocrine cells in the small intestine. Paper-2130754.
The evidence for the regulatory role of endogenous GIP as a glucose dependent insulinotropic hormone in patients with duodenal ulcer. Paper-4524405.
GIP cases in the WC industry reveal elevated concentrations of tungsten in all, but cobalt was detected in only 6 ( approximately 10%). Paper-12885516.
We report a case of GIPP with testicular enlargement who was diagnosed to have testotoxicosis and successfully managed with spironolactone. Paper-12054647.
The effect of atropine on plasma gastric inhibitory polypeptide ( GIP), serum insulin, and blood glucose after intraduodenal infusion of fat. Paper-11979679.
The development of aberrant adrenal sensitivity to GIP can result in food-dependent adrenal hyperplasia and therefore in Cushing's syndrome. Paper-7259933.
Autopsy confirmed the presence of numerous giant cells characteristic of GIP with associated fibrosis throughout the transplanted lung. Paper-7628312.
Gastric inhibitory polypeptide release after oral glucose: relationship to glucose intolerance, diabetes mellitus, and obesity. Paper-3982874.
Assuming one molecule of 125I-GIP is bound per molecule of protein, one protein with Mr 59,000 is identified as the specific GIP binding site. Paper-4776708.
In patients with chronic pancreatitis receiving an oral glucose load or mixed liquid test meal, GIP levels have been shown to be exaggerated. Paper-3274254.
The function of salivary GIP is unknown, but we speculate that it may play a role in the regulation of gastric acid secretion in the fasting state. Paper-9768789.
The present results suggest that GIP may have effects other than the insulinogenic one, being probably involved in the control of lipid metabolism. Paper-4517100.
The effects on alpha(i2)-mRNA were accompanied by a parallel, albeit weaker effect on the protein level (only GIP and UK 14,304 were investigated). Paper-2074351.
However, cortisol secretion occurs in response to gastric inhibitory polypeptide ( GIP) in rare cases of food-dependent Cushing's syndrome (CS). Paper-11124257.
GIP as well as GIP-GFP secreted by NIH3T3 cells significantly stimulated intracellular cAMP accumulation and Ca(2+) mobilization in SaOS2 cells. Paper-8785496.
Longer use of ketoconazole to suppress GIPP is required to determine whether this therapy can prolong linear growth with enhancement of final height. Paper-11616933.
Glucose intolerance, hyperinsulinism, and exaggerated gastric inhibitory polypeptide ( GIP) release occurred following glucose ingestion. Paper-4995792.
In conclusion, the present data demonstrate that ectopic expression of functional GIP receptors is the main cause of food-dependent Cushing's syndrome. Paper-1676633.
Treatment with octreotide initially prevented the meal-induced increases in cortisol and GIP levels and decreased urinary cortisol excretion. Paper-663509.
In conclusion, it is presumed that GIP release is affected by gastric acid, gastric emptying time, intestinal transit time and vagal nerve action. Paper-4548694.
The enteric enhancement of glucose-stimulated insulin release. The role of GIP in aging, obesity, and non-insulin-dependent diabetes mellitus. Paper-4547865.
Plasma glucose, serum insulin (IRI), and GIP were evaluated after a mixed meal containing a total of 82 g of carbohydrates, and 2 g sodium chloride. Paper-242220.
GIP hypersecretion may, however, contribute to the increased lipogenesis in obesity and the hypoglycemia in the late dumping syndrome. Paper-4247428.
The glucose-dependent action of GIP on pancreatic beta-cells has attracted attention towards its exploitation as a potential drug for type 2 diabetes. Paper-11434786.
This appears to be the first demonstration of a GIP-stimulated signal transduction pathway involved in increasing fat storage in adipocytes. Paper-12459872.
The gastrointestinal hormone, gastric inhibitory polypeptide ( GIP), is synthesized and released from the duodenum and proximal jejunum postprandially. Paper-2100726.
To explore the effects of increased caloric intake and dietary composition on GIP secretion, 20 normal lean volunteers underwent a 4-week ambulatory study. Paper-4565487.
At 30 min, however, IRI and GIP were higher in normotensives with a family history of hypertension and in established hypertensive versus control subjects. Paper-242220.
CONCLUSIONS: An abnormal GIP response is present in cases of chronic pancreatitis irrespective of the presence or severity of pancreatic insufficiency. Paper-940210.
Plasma gastric inhibitory polypeptide ( GIP) was studied for 24 h in six healthy, young men who ate four meals and performed their usual physical activities. Paper-3523759.
BACKGROUND/AIMS: Gastric inhibitory polypeptide is recognized as an acid inhibitor, while its relationship with Helicobacter pylori colonization is unknown. Paper-1980053.
Eight fasting students were given an infusion of porcine gastric inhibitory polypeptide ( GIP) and glucose with or without atropine on two separate days. Paper-4838912.
Recognition of GIP as a rare manifestation of nitrofurantoin toxicity is important because prompt therapy may be associated with a favorable outcome. Paper-12171556.
GIP receptors are present in the ZF/R of the normal adrenals, and are particularly abundant in some types of adrenocortical adenomas and hyperplasias. Paper-8498144.
It is concluded that the non-selective beta-adrenoceptor antagonist propranolol inhibits the release of GIP after intraduodenal administration of glucose. Paper-3836737.
Enprostil markedly reduced the post-prandial rises in insulin and glucose-dependent insulinotropic peptide ( GIP) but plasma glucose remained unchanged. Paper-6162804.
The adult-onset diabetic group was also studied for immunoreactive GIP (IR- GIP), insulin, and glucose with a test meal before and after tolazamide therapy. Paper-3717407.
Gastrointestinal peptides and neoplasia ectopic gastric inhibitory polypeptide ( GIP) receptors in adrenal glands causing food-dependent Cushing's syndrome. Paper-12778593.
There was a close correlation between circulating gastric inhibitory polypeptide ( GIP) and cortisol levels during normal food intake (r = 0.92; P < 0.0002). Paper-663509.
Glucose-dependent insulinotropic polypeptide stimulates insulin secretion via increased cyclic AMP and [Ca2+]1 and a wortmannin-sensitive signalling pathway. Paper-605325.
There were no significant differences in the rates of gastric acid or chloride output between the experimental periods with placebo or any dose of GIP. Paper-11833187.
In the present study we identified Forkhead (Foxo1)-mediated suppression of the bax gene as a critical component of the effects of GIP on cell survival. Paper-10742543.
Variables assayed were plasma glucose, insulin and glucose-dependent insulinotropic peptide ( GIP) levels for 2 h and diet-induced thermogenesis (DIT) for 5 h. Paper-8397794.
Phase I study with dose escalation of gemcitabine and cisplatin in combination with ifosfamide ( GIP) in patients with non-small-cell lung carcinoma. Paper-10252731.
Our study suggests that the timing of adrenarche and central puberty in these subjects with GIP was apparently unaltered by prolonged exposure to gonadal steroids. Paper-7386713.
CONCLUSIONS: These studies provide further evidence for an important physiologic role for GIP in lipid homeostasis and possibly in the pathogenesis of obesity. Paper-12630473.
It is proposed that a factor of intestinal origin is released during intake of carbohydrates, which blocks the B-cell response to the combined glucose- GIP stimulus. Paper-4164717.
A cross-sectional analysis of adrenal androgen secretion was performed in nine additional patients to assess further the time course of adrenarche in GIP. Paper-7386713.
DISCUSSION: These studies provide further evidence for an important physiological role for GIP in lipid homeostasis and possibly in the pathogenesis of obesity. Paper-12170766.
This effect is not due to diversion of portal blood to the systemic circulation and may be attributable to hypersensitivity of the alpha-cells to stimulation by GIP. Paper-6865271.
METHODS: A retrospective follow-up study has been conducted using drug prescription data from the database of the Dutch Drug Information Project ( GIP database). Paper-10884668.
It is concluded that porcine GIP is glucagonotropic in patients with cirrhosis of the liver who show elevated levels of IRG in the plasma in the postabsorptive state. Paper-6865271.
However, eliminating the effect of endogenous GIP may at the same time impair postprandial insulin secretion, thereby severely disturbing glucose homeostasis. Paper-11580824.
We studied the putative influence of food intake on the hypothalamo-pituitary-adrenal (HPA) axis in patients with adrenal incidentalomas and possible mediation by GIP. Paper-8399685.
These two proteins, GIP I and II (28 kD and 9.5 kD, respectively, in molecular weight), block effective bacterial killing, chemotaxis, and oxygen metabolism. Paper-488629.
Although hyperinsulinism, hypoglycemia, and suppression of endogenous insulin secretion were produced in the controls, no suppression of baseline GIP was detected. Paper-3187069.
A novel mechanism for the suppression of a voltage-gated potassium channel by glucose-dependent insulinotropic polypeptide: protein kinase A-dependent endocytosis. Paper-10784581.
Formula fed infants had a greater insulin and GIP response to feeding and their basal and postprandial blood ketones were considerably lower than in breast fed infants. Paper-3903395.
The case of a patient with yellow nail syndrome (YNS), an infiltrating duct carcinoma of the breast, and giant cell interstitial pneumonitis ( GIP) is presented. Paper-5430034.
Impairment of the insulinotropic effect of gastric inhibitory polypeptide ( GIP) in obese and diabetic rats is related to the down-regulation of its pancreatic receptors. Paper-12635780.
The signal transduction pathways of a cloned human gastric inhibitory polypeptide (GIP) receptor have been investigated in CHO cells stably expressing this receptor. Paper-1065992.
Plasma GIP concentration increased significantly with enteral glucose administration in all infants but remained unchanged with parenteral glucose infusion. Paper-6443325.
Our preliminary experience indicates the safety and effectiveness of ketoconazole as a therapy for GIPP with potential advantages over previously used modes of treatment. Paper-11616933.
In conclusion, under conditions of stable hyperglycemia, the ingestion of a small amount of glucose elicited equivalent GIP responses in both lean and obese children. Paper-8464271.
Half-maximal stimulation is observed in the presence of 30 nM GIP, maximal stimulation induced by 10(-6) M peptide increases up to 4 times the basal cyclic AMP production. Paper-4532036.
The current report examines the N-terminal bioactive domain of GIP residing in residues 1-14 by alanine scanning mutagenesis and N-terminal substitution/modification. Paper-10530052.
Five vagotomized male subjects were given graded doses of pentagastrin without and with a background infusion of 2 microgram/kg/hr of gastric inhibitory polypeptide ( GIP). Paper-3932513.
The GIP was shown to be growth-suppressive in nine human tumor types and to suppress the spread of tumor infiltrates and metastases in human and mouse mammary cancers. Paper-11479779.
The GIP was tested in vitro for anticancer activity and was found to suppress the growth in 38 of 60 human cancer cell lines, representing nine different cancer types. Paper-10193662.
Gonadotropins independent precocious puberty ( GIPP) in male is characterized by early appearance of sexual hairs and phallic growth but without testicular enlargement. Paper-12054647.
It had no effect on plasma levels of insulin during euglycemia but decreased plasma insulin during hyperglycemia. ex(9-39)NH2 did not alter GIP-stimulated insulin secretion. Paper-1381154.
We conclude that the enteroinsular axis in terms of IR- GIP is overactive in adult-onset diabetics; tolazamide therapy does not appear to effect its meal-stimulated response. Paper-3717407.
Aberrant gastric inhibitory polypeptide (GIP) receptor expression in bilaterally hyperplastic adrenals or unilateral adrenal adenomas is a rare form of adrenal hyperfunction. Paper-8676525.
OBJECTIVE: The purpose of our study was to describe the high-resolution CT and pathologic findings of giant cell interstitial pneumonia ( GIP) in four adult patients. Paper-11115497.
METHODS: A total of 111 patients with mediastinal lymph nodes had undergone EUS-FNA using a linear array echo endoscope and a 170 cm, 22 G GIP needle consecutively. Paper-8610713.
MATERIALS AND METHODS: On separate occasions we performed an OGTT and administered an i.v. bolus of 20 pmol GIP/kg body weight in 20 women with pGDM and 20 control women. Paper-11074954.
These data suggested that some somatotroph adenoma cells have an aberrant response to GIP which may go toward explaining paradoxical GH secretions to OGTT in acromegalics. Paper-10172995.
These results suggest that adverse metabolic effects associated with clozapine treatment may be related to its ability to increase intestinal gene expression for GIP. Paper-11772281.
Finally, based on cholinergic studies, it was proposed that GIP could influence the enzymatic activity of membrane acetylcholinesterases during tumor growth and metastasis. Paper-11479779.
RESULTS: After glucose ingestion, subjects with IGT had both hyperinsulinemia and hyperemia, while subjects with type 2 diabetes had both beta- and GIP-cell deficiency. Paper-10464072.
The insulinotropic gut hormone gastric inhibitory polypeptide ( GIP) has been demonstrated to inhibit gastric acid secretion and was proposed to possess "enterogastrone" activity. Paper-10383687.
An extended duration of action of each GIP analogue was demonstrated prior to examining the effects of once daily injections (25nmolkg(-1) body weight) over a 14-day period. Paper-12187616.
However, the correlation between the GIP response and disturbances of the entero-insular axis in some gastrointestinal diseases and, in particular, Type 2 diabetes, is poor.