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Plasma prekallikrein in hypertension. Paper-4188332.
Fletcher factor deficiency and myocardial infarction. Paper-2624161.
Prekallikrein ( Fletcher factor) deficiency in typhoid fever. Paper-3818072.
Plasma prekallikrein and endotoxemia in liver cirrhosis. Paper-3924970.
CRM+ severe Fletcher factor deficiency associated with Graves' disease. Paper-4778112.
Factor XII, kininogen and plasma prekallikrein in abnormal pregnancies. Paper-11005316.
The kininogenin is a glycoprotein containing 18-20% by weight of carbohydrate. Paper-2623907.
Plasma prekallikrein/kallikrein processing by lysosomal cysteine proteases. Paper-10605211.
A significant reduction of the plasma prekallikrein in cirrhosis has been found. Paper-2624141.
Plasma prekallikrein as a prognostic indicator in chronic liver insufficiency. Paper-6825608.
Fine mapping of the H-kininogen binding site in plasma prekallikrein apple domain 2. Paper-9591060.
Strenuous physical exercise did not significantly change plasma prekallikrein levels. Paper-3139234.
The amino acid sequence of factor XI shows 58% identity with human plasma prekallikrein. Paper-5410688.
Activation of human plasma prekallikrein by Pseudomonas aeruginosa elastase in vitro. Paper-7155115.
Multiple cerebral thrombosis in Fletcher factor (prekallikrein) deficiency: a case report. Paper-5097380.
Plasma prekallikrein was measured by its activity on substrate S-2302 after activation. Paper-6830077.
Plasma prekallikrein: a risk marker for hypertension and nephropathy in type 1 diabetes. Paper-9727660.
Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats. Paper-5410687.
This new gene maps to chromosome 19q13.4 and is located between the KLK1 and KLK3 genes. Paper-8690116.
A full length guinea pig plasma prekallikrein (PK) cDNA was cloned from a liver cDNA library. Paper-2112672.
This was the first study to perform association analysis of the KLKB1 gene with essential hypertension. Paper-13171392.
On endothelial cells, plasma prekallikrein is activated by a membrane-associated cysteine protease. Paper-1888626.
Human plasma prekallikrein and high molecular weight kininogen decrease during parturition. Paper-4773013.
Plasma prekallikrein, plasma noradrenaline and plasma atrial natriuretic peptide did not change. Paper-8227936.
These results indicated the participation of plasma prekallikrein in the permeability reaction to beta HFa. Paper-5335006.
Plasma prekallikrein (PPK) decreased in acute pancreatitis, but increased in chronic pancreatitis. Paper-6453389.
Fletcher factor deficiency in a 9-year-old girl: mechanisms of the contact pathway of blood coagulation. Paper-200265.
Fletcher factor deficiency, source of variations of the activated partial thromboplastin time test. Paper-3924188.
Plasma prekallikrein, high molecular weight kininogen, and factor XII levels were not decreased. Paper-1559912.
Kinin and myocardial infarction: effect of Trasylol on the plasma prekallikrein and kallikrein inhibitor. Paper-3153853.
A 59-year-old male patient with Graves' disease and severe hereditary Fletcher factor deficiency is described. Paper-4778112.
A method for assaying plasma prekallikrein has been developed applying the chromogenic substrate Chromozym PK. Paper-3139193.
Immunovisualisation of plasma prekallikrein and H-kininogen on human neutrophils and in human hepatocytes. Paper-7387936.
Direct evidence for multifacial contacts between high molecular weight kininogen and plasma prekallikrein. Paper-703167.
Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein. Paper-11082969.
Complex alternative splicing of the hKLK3 gene coding for the tumor marker PSA (prostate-specific-antigen). Paper-9839317.
Plasma prekallikrein and kallikrein inhibitor did not change during the infusion of either glucose or saline. Paper-2395327.
Plasma prekallikrein levels in patients with hepatocellular carcinoma and liver cirrhosis: a pilot study. Paper-7636365.
Human plasma prekallikrein was fragmented with cyanogen bromide, and 13 homogeneous peptides were isolated and sequenced. Paper-5410687.
Therefore, we prepose that H-kininogen provides the binding site for plasma prekallikrein on circulating neutrophils. Paper-7387936.
Previous investigators have suggested that the biological activity of plasma prekallikrein is defective in cystic fibrosis. Paper-2882144.
Common variation in KLKB1 and essential hypertension risk: tagging-SNP haplotype analysis in a case-control study. Paper-13171392.
After incubation with neuraminidase the kininogenin retained full enzymic activity and possessed an isoelectric point of pH7. Paper-2623907.
Immunoblotting studies of coagulation factor XII, plasma prekallikrein, and high molecular weight kininogen. Paper-5742682.
The structure of two alternative mRNAs (0.9 and 1.65 kb) of the hKLK3 gene that retain the third intron is reported here. Paper-9044196.
Elevated levels of plasma prekallikrein, high molecular weight kininogen and factor XI in coronary heart disease. Paper-9399363.
Plasma prekallikrein, kallikrein inhibitors, kininogen and lipids during gemfibrozil treatment in type II dyslipidaemia. Paper-4188350.
The reduction in plasma prekallikrein may indicate that tenoxicam exerts its anti-inflammatory effect by more than one mechanism. Paper-6335669.
This observation suggests that other sequences within or near KLKB1, or another gene nearby, may contribute to ESRD susceptibility. Paper-8617419.
Mechanized assay of plasma prekallikrein by activation with Pseudomonas aeruginosa elastase and amidolysis of chromogenic substrate. Paper-6855704.
Expression of plasma prekallikrein mRNA in human nonhepatic tissues and cell lineages suggests special local functions of the enzyme. Paper-8289823.
Genomic structure of the human plasma prekallikrein gene, identification of allelic variants, and analysis in end-stage renal disease. Paper-8617419.
Unusual alternative splicing within the human kallikrein genes KLK2 and KLK3 gives rise to novel prostate-specific proteins. Paper-9162055.
Our study examines the effect of sequential preincubation of plasma with chloroform and methylamine on the plasma prekallikrein assay. Paper-4778207.
Primary structure requirements for the binding of human high molecular weight kininogen to plasma prekallikrein and factor XI. Paper-5730619.
Human plasma prekallikrein. Studies of its activation by activated factor XII and of its inactivation by diisopropyl phosphofluoridate. Paper-3657534.
4. Like KLK2 and KLK3, the KLK5 gene is regulated by steroid hormones in the BT-474 breast cancer cell line. Paper-9467664.
Immunochemical studies of human high molecular weight kininogen and of its complexes with plasma prekallikrein or kallikrein. Paper-3657640.
Activation of purified human plasma prekallikrein triggered by cell wall fractions of Escherichia coli and Staphylococcus aureus. Paper-4488405.
In conclusion, plasma prekallikrein seems to indicate whether death is imminent in patients with liver insufficiency due to cirrhosis. Paper-6825608.
Plasma prekallikrein was measured by the kallikrein-like activity on synthetic substrate S-2302 after activation of prekallikrein. Paper-7146651.
In patients with severe toxemia of pregnancy and hydatidiform mole, plasma prekallikrein levels were low, below the normal range. Paper-3928375.
Mapping of the discontinuous H- kininogen binding site of plasma prekallikrein. Evidence for a critical role of apple domain-2. Paper-1999504.
Determination of gene structure by intron trapping using polymerase chain reaction: application to the human plasma prekallikrein gene. Paper-200195.
KLK2 and KLK3 have important applications in prostate cancer diagnostics and, more recently, in breast cancer diagnostics. Paper-8623339.
We studied the ability of fragments of the light chain of human high molecular weight kininogen to bind to plasma prekallikrein. Paper-5413958.
High and low molecular weight kininogen and plasma prekallikrein/plasma kallikrein in villous capillaries of human term placenta. Paper-739636.
We have applied this method to trap introns A, H, and J of human plasma prekallikrein gene and determined their exon-intron junction sequences. Paper-200195.
Expression of the plasma prekallikrein gene: utilization of multiple transcription start sites and alternative promoter regions. Paper-11259174.
Chloroform-induced fibrinolysis. Its dependence on Hageman factor, plasma prekallikrein, and high molecular weight kininogen. Paper-3539305.
Bradykinin (BK) is released directly from kininogens or through activation of either Hageman factor or subsequent plasma prekallikrein. Paper-557184.
During gemfibrozil use, plasma prekallikrein and kininogen were increased significantly while kallikrein inhibitors increased only slightly. Paper-4188350.
The association of KLK3b alleles with ESRD raises the possibility that polymorphisms in KLK3 may play a role in ESRD susceptibility. Paper-1369950.
KLK3 or prostate specific antigen ( PSA) is a serine protease, which is an established tumour marker of prostatic adenocarcinoma. Paper-1792111.
Studies on some coagulation factors ( Hageman factor, plasma prekallikrein, and high molecular weight kininogen) in the normal newborn. Paper-3478689.
It was inhibited by purified antibodies specific for plasma prekallikrein and also by purified C1 inhibitor, but not by antibodies specific for C1s. Paper-3659249.
The amino acid sequence of human plasma prekallikrein was determined by a combination of automated Edman degradation and cDNA sequencing techniques. Paper-5410687.
By RT-PCR, hKLK2 mRNA was detected in 7 patients (33%), and hKLK3 mRNA was detected in 17 (81%) of 21 stage D prostate cancer patients. Paper-1188993.
Plasma prekallikrein was activated to kallikrein by exposure to 50 mg/L dextran sulfate in acetone/water (35/65 by vol) at 0 degrees C for 15 min. Paper-3923665.
Exploratory population pharmacokinetics (e- PPK) analysis for predicting human PK using exploratory ADME data during early drug discovery research. Paper-13907276.
We mapped the KLK3 gene and the marker KLK3c to the long arm of human chromosome 4 between F11 and D4S426 using a radiation hybrid panel. Paper-1369950.
The activation of plasma prekallikrein by single-chain factor XII has been studied in the presence of high molecular weight kininogen and kaolin. Paper-3658895.
The co-localization of kininogen and plasma prekallikrein/plasma kallikrein suggests that kinins could be generated locally in placental capillaries. Paper-739636.
Like the rat plasma kallikrein gene and the closely related human factor XI gene, the human KLKB1 gene contains 15 exons and 14 introns. Paper-8617419.
Immunohistochemical studies localized H- kininogen and plasma prekallikrein/plasma kallikrein to endothelial cells of placental villous capillaries. Paper-739636.
Linkage analysis of affected sibling pairs did not reveal any evidence of linkage of KLK3 to ESRD in all 142 sib-pairs or in the two stratified subsets. Paper-1369950.
Physical and biological significance of peptide sequences mediating the interaction between high molecular weight kininogen and plasma prekallikrein. Paper-1211489.
Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein. Paper-5410688.
Plasma kallikrein ( Fletcher factor) is a hepatic serine proteinase that participated in the early phase of blood coagulation. Paper-6950839.
Our findings suggested that common genetic variation in the KLKB1 gene might contribute to the risk of hypertension in the northern Han Chinese population. Paper-13171392.
In this study, we examined the human plasma kallikrein gene KLK3 to determine whether it contributed to end-stage renal disease ( ESRD) susceptibility. Paper-1369950.
The immediate consequence of plasma prekallikrein activation is the cleavage of high molecular weight kininogen (HK) with liberation of bradykinin. Paper-8645811.
Factor XII-induced fibrinolysis. Diminished proactivator activity and drastic reduction of activator activity in Fletcher factor-deficient plasma gamma globulin. Paper-4208908.
The permeability response to beta HFa was attenuated 5 fold in animals depleted of the circulating plasma prekallikrein by intraarterial antibody administration. Paper-5335006.
Immunoblotting of blood coagulation Factor XII and plasma prekallikrein in whole plasma was performed using radiolabeled antigen for detection. Paper-5411861.
Alteration of factor VII activity by activated Fletcher factor (a plasma kallikrein): a potential link between the intrinsic and extrinsic blood-clotting systems. Paper-2395091.
In this study, we performed a haplotype-based study to assess the effect of common genetic variation in the KLKB1 gene on the risk of essential hypertension. Paper-13171392.
The contact phase of intrinsic clotting involves Factor XI, Factor XII, Fletcher factor, and a fourth activity that we call contact activation cofactor (CAC). Paper-2275216.
A specific method has been established for the measurement of plasma prekallikrein, and validated for blister fluid, skin chamber fluid, plasma and synovial fluid. Paper-7385439.
Decreased concentrations of plasma prekallikrein and high-molecular-mass kininogen were found, providing evidence of activation of the kallikrein-kinin system. Paper-11196892.
Plasma prekallikrein determined by synthetic chromogenic tripeptide substrate was increased with advancing gestational ages, reaching approximately 200% of normal. Paper-3925797.
The promoter and the enhancer region of the KLK 3 (prostate specific antigen) gene is frequently mutated in breast tumours and in breast carcinoma cell lines. Paper-1792111.
Activation of human plasma prekallikrein by Pseudomonas aeruginosa elastase. II. Kinetic analysis and identification of scissile bond of prekallikrein in the activation. Paper-55576.
HK31 (S565-K595) has previously been shown to encompass the binding domain for plasma prekallikrein (PK) within domain 6 of high molecular weight kininogen (HK). Paper-703167.
Additionally, plasma prekallikrein ( Fletcher factor) and high molecular weight kininogen (Fitzgerald factor), a substrate of plasma kallikrein, were normal. Paper-2882144.
HK31 (S565-K595) has previously been shown to encompass the binding domain for plasma prekallikrein (PK) within domain 6 of high molecular weight kininogen (HK). Paper-1211489.
This study of KLKB1 in ESRD has been extended by determining the genomic structure of KLKB1 and searching for allelic variants that may be associated with ESRD. Paper-8617419.
We conclude that taking advantage of the difference between hKLK2 mRNA and hKLK3 mRNA expression is clinically useful for following up prostate cancer patients. Paper-1188993.
We observed that the prekallikrein gene ( Klkb1) is expressed highly in the mammary gland during stromal remodeling periods including puberty and postlactational involution. Paper-13760911.
Detection and quantitation of cleaved and uncleaved high molecular weight kininogen in plasma by ligand blotting with radiolabeled plasma prekallikrein or factor XI. Paper-5960241.
Trypsin (TRY), plasma prekallikrein (PKK), plasma kallikrein ( KK) and functional plasma kallikrein inhibition capacity (KKI) were studied in the peritoneal exudate. Paper-5101956.
KLK5 is a newly discovered human kallikrein gene which shares a high degree of homology and is located adjacent to KLK2 and KLK3 genes on chromosome 19q13. Paper-9467664.
Hageman factor substrates. Human plasma prekallikrein: mechanism of activation by Hageman factor and participation in hageman factor-dependent fibrinolysis. Paper-2884222.
The development of myocardial infarction in a patient who had severe Fletcher factor deficiency emphasizes the importance of alternate pathways for activation of these systems. Paper-2624161.
Furthermore, human systemic lupus erythematosus and lupus nephritis were shown to be associated with kallikrein 1 ( KLK1) and the KLK3 promoter. Paper-13701712.
A lowering of plasma prekallikrein has also been observed in viral hepatitis; in this condition, however, the modifications were less important than those obtained in cirrhosis. Paper-2624141.
The contact factors XI, XII, high molecular weight kininogen (Fitzgerald factor), and prekallikrein ( Fletcher factor) are all markedly decreased in thriving EPT infants. Paper-3292423.
Crystallization and x-ray crystal structure determination of both forms have yielded the first three-dimensional views of the catalytic domain of plasma kallikrein. Paper-11082969.
Of these, only KLK3/ PSA is known to be androgen-regulated while the other genes represent new members of the androgen-response program in prostate epithelium. Paper-9388110.
The serine protease prolylcarboxypeptidase ( PRCP), isolated from human umbilical vein endothelial cells (HUVECs), is a plasma prekallikrein (PK) activator. Paper-10319708.
A kininogenin (EC 3.4.21.8) was purified from the venom of Vipera ammodytes ammodytes (European sand viper) by a combination of gel filtration and ion-exchange chromatography. Paper-2623907.
Plasma prekallikrein activity was low in the propositus, whereas normal levels of antigen could be found, suggesting a defect of kallikrein activation due to factor XII deficiency. Paper-5100441.
Tissue kallikrein ( hK1) and plasma kallikrein (PK, hKB1) are serine proteases that produce biologically active kinin peptides from endogenous kininogen substrates. Paper-12949345.
A decline in plasma prekallikrein levels with an increase in plasma C1-inhibitor-kallikrein complexes suggested activation of kallikrein, probably through the intrinsic coagulation system. Paper-5793492.
Activation of human plasma prekallikrein by a bacterial metalloendopeptidase, Pseudomonas aeruginosa elastase, was reported (Shibuya et al. (1991) Biochim. Biophys. Acta 1097, 23-27). Paper-55576.
Fibrinolytic studies in gamma G fractions of three Fletcher factor-deficient plasmas (functionally deficient in prekallikrein) revealed weak or no factor XII-independent activator activity. Paper-4208908.
The location of 16 of the 18 disulfide bonds in human plasma prekallikrein was determined by amino acid sequence analysis of cystinyl peptides produced by chemical and enzymatic digestions. Paper-6953412.
Both plasma prekallikrein and H-kininogen were immunolocalised in human hepatocytes by the use of immunocytochemical techniques in conjunction with the confocal optical scanning microscopy. Paper-7387936.
On this basis, RGPs associated with vesicles were assumed to be responsible for most of the VPE activity generation via plasma prekallikrein activation and subsequent bradykinin production. Paper-216372.
Assays for known coagulation factors were nromal while Fletcher factor (pre-kallikrein) was 45%, insufficient to account for the observed markedly prolonged partial thromboplastin time. Paper-2290264.
The determination of plasma prekallikrein by direct activation with beta-XIIa in the presence of acetone offers several advantages over the use of contact activators such as dextran sulfate. Paper-4484001.
The effects of gemfibrozil on plasma prekallikrein, kallikrein inhibitors, kininogen and plasma lipids were investigated in 31 male subjects having either type IIA or IIB dyslipidaemia. Paper-4188350.
Enzymes of the contact phase of blood coagulation: kinetics with various chromogenic substrates and a two-substrate assay for the joint estimation of plasma prekallikrein and factor XI. Paper-6008566.
Prostate-specific antigen ( PSA), a 237-amino acid glycoprotein, encoded by the hKLK3 gene, is widely used as a serum marker for the diagnosis and management of prostate cancer. Paper-8928347.
Homozygous states of factor XII deficiency, Fletcher factor deficiency, and high-molecular-weight kininogen deficiency (Fitzgerald trait) also showed abnormally long APTTs by all systems. Paper-3215779.
Many kallikrein genes are differentially expressed in various malignancies and prostate specific antigen ( PSA; encoded by the KLK3 gene) is the best tumor marker for prostate cancer. Paper-9467664.
KLK3 expression is lower in malignant than in normal prostatic epithelium and it is further reduced in poorly differentiated tumors, in which the expression of KLK2 is increased. Paper-12884204.
KLK3 expression is lower in malignant than in normal prostatic epithelium and it is further reduced in poorly differentiated tumors, in which the expression of KLK2 is increased. Paper-13527500.
The prognostic value of plasma prekallikrein activity, prothrombin time, and serum albumin with regard to survival in chronic liver insufficiency was evaluated in 21 consecutive patients. Paper-6825608.
Functionally, the endogenous activation of plasma prekallikrein is of considerable importance, both in the regulation of blood flow and blood pressure and in the causation of septic shock. Paper-2108355.
Furthermore, plasma prekallikrein and functional plasma kallikrein inhibition values in the exudate were elevated significantly in HDC treated animals compared with untreated animals. Paper-5101956.
Serial estimations of plasma prekallikrein in four critically ill patients in intensive care showed reduced values in each case, suggesting activation of the plasma kallikrein kinin system. Paper-4779895.
Binding of a monoclonal anti-human plasma prekallikrein antibody to the complexes of kallikrein with C1-inhibitor and alpha 2-macroglobulin analyzed by immunoblot and "sandwich" assays. Paper-6453023.
Plasma prekallikrein, factor XII, antithrombin III, C1(-)-inhibitor and alpha 2-macroglobulin in critically ill patients with suspected disseminated intravascular coagulation (DIC). Paper-4774194.
PSA (prostate-specific antigen), the most useful serum marker for prostate cancer, is encoded by the hKLK3 gene and is present in the serum as a mixture of several molecular species. Paper-9839317.
Addition of purified human plasma prekallikrein to the IAF-light chain resulted in a maximum increase in fluorescence anisotropy of 0.041 +/- 0.001 and no change in the fluorescence intensity. Paper-4489426.
The problem factor was probably not Fletcher factor, because the abnormal partial thromboplastin time was not significantly shortened by increasing the incubation period of plasma with kaolin. Paper-3068031.
The inheritance of Fletcher trait in this patient is unclear.l Although the father was an apparent heterozygote, the mother was completely normal for Fletcher factor procoagulant activity and antigen. Paper-4206473.
Like the proclotting enzyme, mature factor B is composed of an amino-terminal "clip"-like domain and a carboxyl-terminal serine protease domain homologous to that of human plasma prekallikrein (36.5%). Paper-7847092.
After treatment had begun they were investigated for blood pressure control, family history of hypertension, renal function and urinary kallikrein and plasma prekallikrein concentrations. Paper-7207494.
Factor XI ( FXI), the zymogen of the blood coagulation protease FXIa, and the structurally homologous protein plasma prekallikrein circulate in plasma in noncovalent complexes with H-kininogen (HK). Paper-9155810.
In this study, we detected prostate cancer cells that expressed hKLK2 or hKLK3 mRNA in the peripheral blood of patients with prostate cancer using reverse transcription-PCR ( RT-PCR). Paper-1188993.
The active site of the molecule was required for the priming, because plasma prekallikrein, active site-inactivated plasma kallikrein, and soybean trypsin inhibitor treated kallikrein did not prime PMN. Paper-6453762.
The expression of plasma prekallikrein (PPK) mRNA has been investigated applying reverse transcription, followed by polymerase chain reaction, of mRNA ( RT-PCR) in various human and rat tissues. Paper-7752132.
The C-terminal end of the heavy chain of human plasma prekallikrein or kallikrein contains a binding site for high-molecular-weight kininogen, the nonenzymatic procofactor of contact activation. Paper-135197.
Spontaneous kallikrein activity (KK), plasma prekallikrein (PKK), functional kallikrein inhibition capacity (KKI), C3 activation products ( C3-act), and the terminal complement complex (TCC) were measured. Paper-6448363.
The carboxyl-terminal portion of plasma prekallikrein containing the catalytic region of the molecule was found to have disulfide bonds located in positions similar to those of other serine proteases. Paper-6953412.
Previously it was believed that plasma prekallikrein (PPK), the precursor of PK and a member of the serine protease superfamily, was synthesized exclusively by hepatocytes and secreted into circulation. Paper-10591813.
We then demonstrated some differences in characteristics, such as differentiation of cancer cells and response to antiandrogen therapy, between hKLK2 and hKLK3 mRNA-expressing prostate cancer cells. Paper-1188993.
This most likely represents a coincidental occurrence, but the markedly elevated peripheral blood lymphocyte count and the detection of the defect using ellagic acid are unique for Fletcher factor deficiency. Paper-3660629.
Short sequence repeat polymorphisms for the human plasma kallikrein gene ( KLKB1; previously known as KLK3) on chromosome 4 were associated with ESRD in an African American study population. Paper-8617419.
The case of a patient who, while being treated for an acute myocardial infarction, was found to have Fletcher factor deficiency with a Fletcher factor concentration of less than 1% of normal is described. Paper-2624161.
The intron sequences thus obtained will be useful in designing primers for exon trapping and sequence analysis of plasma prekallikrein gene from patients with defective plasma prekallikrein. Paper-200195.
In the deficient group, the total kininogen concentration gradually decreased after alcohol intake due to a reduction in low molecular weight kininogen, and plasma prekallikrein remained unchanged. Paper-6813710.
In an examination of the mechanism involved we now report the activation, in addition, of plasma prekallikrein and serine proteinase activity, but not plasminogen, when human plasma is incubated with venom. Paper-3923902.
Many kallikrein genes have been found to be differentially expressed in various malignancies, and prostate-specific antigen ( PSA; encoded by the KLK3 gene) is the best tumor marker for prostate cancer. Paper-9520569.
Exclusion analysis indicated that the KLK3 gene could be excluded from contributing to ESRD at a relative risk of 3 when the maximum log of the odds score of -2 was used as the criterion for exclusion. Paper-1369950.
This paper reports an asymptomatic coagulation defect responsible for an abnormality at the contact phase of blood coagulation in vitro, distinct from Hageman factor and Fletcher factor deficiencies. Paper-2439947.
The aim of this study was to investigate the expression of tissue prokallikrein (pro- hK1), plasma prekallikrein ( PPK, pre-hKB1) and kinin B1 and B2 receptor proteins in different subtypes of lung cancer. Paper-12949345.
Identification of the binding site for plasma prekallikrein in human high molecular weight kininogen. A region from residues 185 to 224 of the kininogen light chain retains full binding activity. Paper-5413958.
Both FXII and the complex plasma prekallikrein/high molecular mass kininogen become activated when they bind, in a Zn2+-dependent manner, to receptors on human umbilical vein endothelial cells (HUVEC). Paper-9684914.
The concentration of plasma prekallikrein (PK) in five patients with hepatocellular carcinoma ( HCC) has been measured and related to levels in 18 patients with liver cirrhosis (LC) and 30 healthy subjects. Paper-7636365.
The prolonged activated partial thromboplastin times observed with Fletcher factor (prekallikrein)-deficient plasmas become nearly normal after the plasma is incubated with contact surfaces or with an activator. Paper-3424141.
Plasma kallikrein is a serine protease that has many important functions, including modulation of blood pressure, complement activation, and mediation and maintenance of inflammatory responses. Paper-11082969.
Eight common single nucleotide polymorphisms ( SNPs) were selected from the HapMap database and used to determine the pattern of linkage disequilibrium (LD) and haplotype structure within the KLKB1 gene. Paper-13171392.
It is concluded that the inheritance is as described by Veltkamp and that the Kallikrein release from the prekallikreinogen ( Fletcher factor) " in vitro" is related to the amount of Factor XII procoagulant protein. Paper-3425958.
The NH2-terminal sequences of human plasma prekallikrein and the heavy and light chains of kallikrein have been determined and compared with those of bovine prekallikrein and of human and bovine factors XII and XI. Paper-5411805.
Severe Fletcher factor ( plasma prekallikrein) deficiency with partial deficiency of Hageman factor (factor XII): report of a case with observation on in vivo and in vitro leukocyte chemotaxis. Paper-4206473.
A modified activated partial thromboplastin time assay for CAC has been defined by using a substrate of Dicalite-adsorbed plasma combined with partially purified sources of Factors XI and XII, and Fletcher factor. Paper-2275216.
Fletcher factor deficiency is associated with defects in several interrelated systems, including clotting, fibrinolysis and kinin generation, all of which play a role in the pathogenesis and evolution of infarction. Paper-2624161.
Of note were a common polymorphism (30% of the population) at position 521 of KLKB1 cDNA, which leads to the replacement of asparagine with a serine at position 124 in the heavy chain of the A2 domain of the protein. Paper-8617419.
We recently identified residues 185-224 of the light chain of human high molecular weight kininogen (HMWK) as the binding site for plasma prekallikrein (Tait, J.F., and Fujikawa, K. (1986) J. Biol. Chem. 261, 15396-15401). Paper-5730619.
The mean titers of Hageman factor, plasma prekallikrein and serum hemolytic complement activity were decreased at the time of admission and 2 hours after treatment, and rose to normal values during convalescence. Paper-2812303.
The proportional reduction of plasma prekallikrein and kallikrein inhibitor suggested that an enzyme-inhibitor complex formed in vivo, perhaps at a local site of activation in proximity to the glomerular basement membrane. Paper-2388541.
Plasma prekallikrein (PPK) is synthesised in hepatocytes and secreted into the blood, where it participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. Paper-13388338.
A sequence of 31 amino acids (S565-K595) in domain 6 of the light chain of high molecular weight kininogen (HK) has previously been shown to be responsible for the binding of plasma prekallikrein (PK) or kallikrein. Paper-1089318.
We measured factor XII (FXII), factor XI ( FXI), plasma prekallikrein (PK) and high-molecular-weight kininogen (HK) in 200 patients having survived myocardial infarction for at least 2 months, and in 100 healthy controls. Paper-9399363.
The PT did not change in blood deficient in factor XII or in plasma deficient in Fletcher factor or high molecular weight kininogen, while blood deficient in CI esterase inhibitor (CI INH) had the most profound shortening. Paper-4142430.
Incubation of Fletcher-trait plasma (deficient in a plasma prekallikrein) with kaolin at 0 degrees C. did not induce shortening of the Thrombotest time or enhancement of factor VII activity, in contrast to studies of normal plasma. Paper-2395091.
Factor XII, plasma prekallikrein, alpha 2-macroglobulin and C1-inhibitor levels in renal allograft recipients during immunosuppression with cyclosporin A--sequential measurements over four months in 17 patients. Paper-5764751.
No changes in PGE2 and TXB2 excretions were found, whereas plasma prekallikrein was reduced (P less than 0.05) and urinary excretion of kallikrein (P less than 0.05) and noradrenaline (P = 0.06) increased under nifedipine. Paper-7179503.
Because H- kininogen and plasma prekallikrein circulate in a complexed form, we suggest that endothelial cells bind kininogen and plasma prekallikrein in which they are secreted by the fetal liver from fetal blood. Paper-739636.
The human plasma kallikrein gene ( KLKB1) encodes plasma kallikrein, a serine protease that catalyzes the release of kinins and other vasoactive peptides and may be involved in the pathogenesis of hypertension. Paper-13171392.
Whereas normal plasma and plasmas deficient in factor XII, factor XI, or Fletcher factor yielded about 4% adsorption to glass, factor XI adsorption from patient's plasma was less than 1%, indicating the presence of an adsorption inhibitor. Paper-3789746.
Therefore, these studies suggest that severe prekallikrein ( Fletcher factor) deficiency in man is not associated with any clinically significant impairment in hemostasis, fibrinolysis, inflammatory responses or leukocyte function. Paper-2626535.
In contrast, samples taken early from 15 patients attending an accident and emergency department with multiple trauma showed significantly elevated plasma prekallikrein concentrations; the significance of this observation is at present unclear. Paper-4779895.
In this report, we described two systems ( Pichia pastoris and baculovirus/Sf9 cells) for expression of the protease domain of plasma kallikrein, along with the purification and high resolution crystal structures of the two recombinant forms. Paper-11082969.
Because plasma kallikrein activates human neutrophils, and in plasma prekallikrein (PK) circulates complexed with high molecular weight kininogen (HMWK), we determined whether HMWK could mediate kallikrein's association with neutrophils. Paper-6445068.
Two siblings with hereditary Fletcher factor (prekallikrein) deficiency were studied for alterations of fibrinolysis, platelet function, skin inflammatory responses, permeability factor (PF/dil) formation and leukocyte chemotaxis. Paper-2626535.
The human kallikrein gene family is localized on chromosome 19q13.3-q13.4 and currently includes three members: KLK1 or pancreatic/renal kallikrein, KLK2 or human glandular kallikrein and KLK3 or prostate-specific antigen ( PSA). Paper-2093789.
Plasma prekallikrein (kallikreinogen) and kallikrein inhibitor, assayed with the kaolin activable esterase method, have been evaluated in 20 patients with hepatic cirrhosis, in 12 cases with jaundice from acute viral hepatitis, and in 9 normal. Paper-2624141.
Since plasma kallikrein activates human neutrophils, and in plasma prekallikrein (PK) circulates complexed with high molecular weight kininogen (HK), we determined whether HK could mediate kallikrein's association with neutrophils. Paper-6516705.
More recently, a durable reduction of plasma prekallikrein and of the plasma inhibitor of kallikrein, both evaluated with the kaolin contact method, has been demonstrated to support the implication of the kinin system in the course of myocardial infarction. Paper-2624151.
Contact activation of plasma prekallikrein (PPK) assayed by a tripeptide chromogenic substrate, and surface-mediated fibrinolysis by the euglobulin test (both tests being insensitive to the anticoagulant effect of heparin and heparinoids) were studied. Paper-3661862.
Incubation of purified human plasma prekallikrein with sulfatides or dextran sulfate resulted in spontaneous activation of prekallikrein as judged by the appearance of amidolytic activity toward the chromogenic substrate H-D-Pro-Phe-Arg-p-nitroanilide. Paper-5729929.
Therefore, although polymorphisms in the coding and 5'-proximal promoter of KLKB1 show no statistically significant association with ESRD in African Americans, there is still evidence for association of this part of chromosome 4 with ESRD. Paper-8617419.
Finally, both human SLE and spontaneous lupus nephritis were found to be associated with kallikrein genes, particularly KLK1 and the KLK3 promoter, when DNA SNPs from independent cohorts of SLE patients and controls were compared. Paper-13701716.
In active ulcerative colitis patients, a significant decrease of plasma prekallikrein, high molecular weight kininogen, and C1 inhibitor levels was observed as compared with controls, as well as prekallikrein activation on western blots. Paper-1255910.
By immunolocalization techniques, and using specific antibodies directed against the various contact factors, we now demonstrate that plasma prekallikrein (PK), factor XI ( FXI), and factor XII (FXII) are present on the exterior face of the human neutrophil. Paper-8065843.
In three cases of hepatitis, the behaviour of the plasma prekallikrein and kallikrein inhibitor have been controlled during the period of the disease and compared with the behaviour of some conventional parameters, such as serum transaminases and bilirubin. Paper-2624141.
Interactions among Hageman factor (HG, Factor XII), plasma thromboplastin antecedent ( PTA, Factor XI), plasma prekallikrein (PK, Fletcher factor) and high molecular weight kininogen (HMW-K, Fitzgerald factor) in blood coagulation. Paper-3274633.
We assessed men with localized prostate cancer or castration-refractory prostate cancer (CRPC) for CTCs via real-time RT-PCR assays for KLK3 [ kallikrein-related peptidase 3; i.e., prostate-specific antigen ( PSA)] and KLK2 mRNAs. Paper-13686223.
Factor XII, plasma prekallikrein and high molecular weight kininogen were first identified as coagulation proteins in the intrinsic pathway because patients deficient in these proteins had marked prolongation of in vitro surface-activated coagulation time. Paper-11005316.
However, detection of H-kininogen on non-fixed but not on fixed neutrophils with the anti-domain 6 antibody (directed at the prekallikrein binding site on H-kininogen), suggested that access to the epitope was blocked by the presence of the bound plasma prekallikrein. Paper-7387936.
Thus, high molecular weight kininogen was needed for expression of Hageman factor's clot- promoting properties and plasma prekallikrein played a minor role in the interaction of ellagic acid-treated Hageman factor and plasma thromboplastin antecedent. Paper-3402588.
With the kaolin-cephalin activated partial thromboplastin time technic, the plasmas of persons who have Fletcher factor deficiency have shown considerable shortening of clotting times when contact activation has been lengthened from 3 (PTT-3) to 10 minutes (PTT-10). Paper-2444897.
The transcription start sites (TSSs) of the human plasma prekallikrein gene ( KLKB1) determined in RNA from kidney are mostly localized within intron 1 and exon 2, suggesting that the region encompassing exon 1, intron 1, and exon 2 comprises an alternative promoter. Paper-13774993.
In addition to a low titer of PTA (less than 0.01 U/ml), plasma assayed at 20-fold dilution also showed low titers of Hageman (factor XII, 0.02 U/ml), Fletcher ( plasma prekallikrein, 0.02 U/ml), and Fitzgerald (high molecular weight kininogen, less than 0.01 U/ml) factors. Paper-4786337.
The inactive-renin-activating, plasma prekallikrein-activating and serine proteinase-activating activities could be accounted for to a large extent by a venom metalloproteinase which was estimated to have a Mr of 24,000 by sodium dodecyl sulphate (SDS)-polyacrylamide gel electrophoresis. Paper-3923902.
Human plasma prekallikrein, precursor of the bradykinin-generating enzyme, was activated in a purified system under a near physiological condition ( pH 7.8, ionic strength I = 0.14, 37 degrees C) by Pseudomonas aeruginosa elastase which is a tissue-destructive metalloproteinase. Paper-7155115.
It is also of interest to emphasize that 3 of the siblings suffered from congenital multiple arthrogryposis and that 2 of them presented the arthrogryposis together with the Fletcher factor deficiency, a circumstance which could have been favored by the consanguinity of the parents. Paper-3140401.
We measured the circulating levels of plasma prekallikrein (PK) activity, factor XII, and high-molecular weight kininogen in the plasma of 636 type 1 diabetic patients from the Diabetes Control and Complications Trial/ Epidemiology and Diabetes Intervention and Complications Study cohort. Paper-9727660.
As a first step in examining the possibility that local kinin release may account for the proteinuria in this disorder, two parameters of the plasma kinin-generating system, plasma prekallikrein and kallikrein inhibitor, were assayed during 27 nephrotic episodes in 21 corticosteroid-responsive children. Paper-2388541.
RESULTS: Both SNP and gene-based analyses showed promising associations with breast cancer risk for 17 genes: OR10J3, FCER1A, NCF4, CNTNAP1, CTNNB1, KLKB1, ITGB2, ALOX12B, KLK2, IRAK3, KLK4, STAT6, NCF2, CCL1, C1QR1, MBP and NOS1. Paper-13967965.
Sodium dodecyl sulfate polyacrylamide gel electrophoresis ( SDS-PAGE) of whole plasma is followed by electrotransfer of the electropherogram to nitrocellulose membranes and detection of the blotted HMW-kininogen with its physiologic ligands, radiolabeled plasma prekallikrein or radiolabeled factor XI. Paper-5960241.
The role of the bradykinin-generating system in the pathogenesis of cancer was explored by simultaneously measuring plasma prekallikrein (PK), the precursor of kallikrein, which is the major enzyme responsible for kinin generation, and plasma kininogens ( KNG), which are precursors of kinin, in patients with various cancers. Paper-7156894.
PPK/ PK was localised in hepatic epithelial cells of the liver, in cells of the pancreatic islet of Langerhans, in the interstitial Leydig cells of the testes, in the follicular and thecal granulosa cells of the ovary, and in the parotid gland, oesophagus, skin, respiratory tract, prostate and breast. Paper-13388338.
Studies of plasmas from individuals with Hageman trait ( factor XII deficiency), plasma thromboplastin antecedent ( PTA, factor XI) deficiency, Fletcher trait ( plasma prekallikrein deficiency) and Fitzgerald trait (high molecular weight-kininogen deficiency) have revealed the importance of these proteins in blood coagulation. Paper-3274633.
Three Japanese patients demonstrated plasma prekallikrein (PK) deficiency ( PKD) after an examination of the proband family line named ' PKD Seki'. A molecular genetic analysis of these PK genes showed homozygous amino acid substitutions Gly104Arg and Asn124Ser in exon 5, which encodes part of the apple domain 2 (A2) of the heavy chain. Paper-13300589.
Every breast cancer cell line exhibited a distinct expression pattern of the nuclear receptor co-regulators examined raising the possibility that the relative levels of these co-activators/-repressors might differentially modulate androgen receptor transcriptional activity within the promoter/ enhancer region of KLK2 and KLK3 of these cells. Paper-9513602.
We examined previously the steroid hormone regulation of 2 known androgen-regulated kallikreins, KLK3 (encoding PSA) and KLK2 (encoding human kallikrein 2 or hK2) in BT-474, T-47D, ZR75-1, MCF-7, MFM-223 and BT-20 human breast cancer cells and found that they were differentially regulated, with the cells showing variable responses to androgen. Paper-9513602.
These synonyms are used for gene KLKB1 (kallikrein B, plasma (Fletcher factor) 1): PPK, Plasma prekallikrein, Plasma kallikrein, KLK3, Kininogenin, Fletcher factor.
These accession numbers are used for gene KLKB1: C9J075 (UNIPROT__AC), B2R8H9 (UNIPROT__AC), AW182528 (NCBI_GENBANK__AC), AAI17350 (NCBI_GENBANK__AC).
KLKB1 is a homologue of KLKB1 (kallikrein B, plasma (Fletcher factor) 1) from Bos taurus.
KLKB1 is a homologue of KLKB1 (kallikrein B, plasma (Fletcher factor) 1) from Canis lupus familiaris.
KLKB1 is a homologue of Klkb1 (kallikrein B, plasma 1) from Mus musculus.
KLKB1 is a homologue of Klkb1 (kallikrein B, plasma 1) from Rattus norvegicus.
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iHOP - Information Hyperlinked over Proteins .
Concept & Implementation by Robert Hoffmann.