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The properties of human DRS transient expressed in COS cells were examined. Paper-174902.
Similar activity was observed with biotin- and 6xHis-tagging of hDRS. Paper-13215123.
Action plan for drug-resistant Streptococcus pneumoniae. The DRSP Working Group. Paper-755139.
MAIN OUTCOME MEASURES: Modified Ashworth (MAS) and Disability Rating ( DRS) scales. Paper-11474279.
The DRS was administered to each person at discharge from in-patient rehabilitation. Paper-1814852.
Neither EE/ DRSP nor EE/ DSG showed clinically significant effects on blood pressure. Paper-10670044.
In a stepwise regression analysis, only DRS scores were predictive of MMAA performance. Paper-9969928.
Higher purity but significantly lower yields of hDRS were obtained using biotin-tagging. Paper-13215123.
Both hDRS and hDRS delta 32 bound to hydrophobic interaction gels such as aminohexyl-agarose. Paper-85465.
DRSP is a spironolactone-like progestin with antiandrogenic and antimineralocorticoid activity. Paper-9056750.
The relation between hours of exercise per week and BR [log ( DRS)] was estimated by linear regression. Paper-9077055.
We suggest that the function of pinin is to pin intermediate filaments to the desmosome. Paper-800468.
STUDY DESIGN: We analyzed a population-based data set of 62,527 EE/ DRSP users ( Dimension Rx, Caremark). Paper-12563072.
A cell surface desmosome-associated component: identification of tissue-specific cell adhesion molecule. Paper-5202041.
Present data also indicate that EE/ DRSP has a favorable effect on the symptoms of premenstrual syndrome. Paper-8737986.
Change in gene expression subsequent to induction of Pnn/ DRS/ memA: increase in p21(cip1/ waf1). Paper-9026454.
Pinin is a desmosome-associated protein occurring in epithelia, cardiac muscle, and meninges. Paper-2019894.
The DRS-values of all the doses of salbutamol differed significantly from placebo and from each other. Paper-6534096.
AR, quantified by the loge dose-response slope to methacholine ( DRS), had a h2N of 30.3% (SE = 12.3%). Paper-8588983.
Pinin/ DRS/ memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells. Paper-10041589.
The catalytic constant of hDRS delta 32 for aminoacylation of tRNA was 2-fold higher than that of hDRS. Paper-85465.
We sought to determine whether EE/ DRSP use might lead to adverse effects possibly attributable to hyperkalemia. Paper-13045129.
Pnn/ DRS protein is associated with desmosomes and colocalizes with splicing factors in nuclear speckled domains. Paper-10009288.
Ubiquitin, SUMO, biotin, and hexahistidine tags did not appreciably interfere with hDRS activity. Paper-13215123.
AR, quantified by the log(e) dose-response slope to methacholine ( DRS), had a h(2)(N) of 30.0% (SE = 12.3%). Paper-8398519.
One EE/ DRSP initiator and four comparators were diagnosed specifically with hyperkalemia (RR 0.5, 95% CI 0.0-4.9). Paper-13045129.
In addition, the inclusion of EE in a betadex clathrate does not affect the pharmacokinetics of either EE or drsp. Paper-12744428.
Northern analyses revealed diminished pinin mRNA in renal cell carcinomas (RCC) and certain cancer cell lines. Paper-2096512.
RESULTS: Of 25 subjects who received EE/ DRSP (N = 12 with EE and N = 13 with placebo), 21 completed treatment. Paper-12653766.
Digital subtraction radiography ( DRS) was utilized to evaluate the anatomy and function of the bladder and urethra. Paper-5869148.
In this study, we found that ectopic expression of the Drs protein induced apoptosis in human cancer cell lines. Paper-10290637.
No associations were found between the psychometric data and measures of PIP and MEMA leakage from REM into NREM. Paper-3184753.
Combined with EE (3 mg DRSP+30 microg EE), DRSP provides effective inhibition of ovulation and cycle control. Paper-10174693.
Additionally, cognitive profiles have not been investigated across different levels of dementia as determined by the DRS. Paper-9987000.
DRSP decreased blood pressure in male hypertensive rats, whereas an increase was noted under conventional progestins. Paper-10174693.
Genomic Southern blots revealed the existence of one gene for pinin, suggesting alternative splicing of the mRNA. Paper-800468.
PURPOSE: Pinin (Pnn/ DRS/ memA) plays an important role in regulating cell-cell adhesion of corneal epithelial cells. Paper-10766067.
Electron-rich, bulky PNN-type ruthenium complexes: synthesis, characterization and catalysis of alcohol dehydrogenation. Paper-12373655.
The kinetics of the N-terminal 32 residue-deleted human aspartyl-tRNA synthetase ( hDRS delta 32) was analyzed. Paper-146230.
A significant and consistent weight loss was seen with DRSP/EE compared to a reference preparation containing desogestrel. Paper-10687581.
Multiple linear regression analyses of various transformations of the DRS also indicated a higher degree of BHR in females. Paper-997975.
The COC 3-mg DRSP/20-microg EE 24/4 regimen is a suitable option for women with moderate acne vulgaris who require contraception. Paper-12948153.
Rationale and design of the MEMA kwa Vijana adolescent sexual and reproductive health intervention in Mwanza Region, Tanzania. Paper-12134699.
The relationships between DBNN's and other models (linear perceptron, piecewise-linear perceptron, LVQ, and PNN) are discussed. Paper-12731796.
This effect is likely due to the antimineralocorticoid activity of DRSP, which counteracts the water retention elicited by estrogen. Paper-13113419.
The zinc fingers of the SR-like protein ZRANB2 are single-stranded RNA-binding domains that recognize 5' splice site-like sequences. Paper-13708616.
GST- hDRS formed high molecular weight aggregates while GST- hDRS delta 32 was a dimeric protein. Paper-85465.
We have previously identified an SR-like protein, pinin (pnn), which is localized not only in nuclear speckles but also at desmosomes. Paper-9480683.
The mean LDL cholesterol values increased by 10.6% vs. baseline in the DSG group and remained nearly stable in the DRSP group (+1.8%). Paper-10240879.
Together, the university and the medical center created what neither one alone could have: the perinatal nurse practitioner ( PNNP) program. Paper-7802495.
It has been developed in combination with ethinylestradiol for use as an oral contraceptive (EE/ DRSP, Yasmin, Schering AG, Berlin, Germany). Paper-8737991.
An advanced practice nursing role, the perinatal nurse practitioner ( PNNP) was implemented to provide collaborative care for these patients. Paper-11758375.
Recently, a new combined oral contraceptive containing 30 microg ethinylestradiol and 3 mg drospirenone (Yasmin, EE/ DRSP) has been developed. Paper-8737986.
No generally accepted method has so far become available for consideration of minor histocompatibility antigens in the context of DRS for BMT. Paper-6140806.
The localization of pinin to the desmosomes has been correlated with the reinforcement of intercellular adhesion and increased IF organization. Paper-8355202.
DRSP also prevented hypertension and fetal growth retardation in pregnant rats after L-NAME, an inhibitor of nitric oxide synthase. Paper-10174693.
Immunohistochemical examination of tumor samples demonstrated absent or greatly reduced pinin in transitional cell carcinoma (TCC) and RCC tumors. Paper-2096512.
Overall we demonstrated ubiquitin and SUMO fusion proteins similarly enhanced the proper folding of hDRS expressed in E. coli. Paper-13215123.
GSTP1 Val105/Val105 genotype in the child was associated with a reduced risk of atopy (P = 0.038) and AHR (PC20, P = 0.046; DRS, P = 0.032). Paper-10052282.
Here I present evidence that pinin exists simultaneously at the desmosome and within the nucleus by generating location-specific monoclonal antibodies. Paper-2019894.
An SR-like GSH uptake appeared in microsomes obtained from an HEK-293 (human embryonic kidney 293) cell line after transfection of RyR1. Paper-10049147.
Previous work has suggested that Pnn/ DRS/ memA is a potential tumor suppressor involved in the regulation of cell adhesion and cell migration. Paper-9026454.
This report summarizes results of recent investigations by CDC and state public health officials of DRSP in communities in Kentucky and Tennessee. Paper-11708119.
Comparison of 1978 and 1983 ratings revealed increased dyskinesia scores, which was statistically significant on the DRS Choreo-athetosis cluster. Paper-5116765.
When we used noise to modulate the off rate of the Ca(2+) binding proteins in simulation, an SR-like phenomenon of synchronous oscillations is observed. Paper-9117582.
PURPOSE: To describe the key objectives, aims, activities and vision for the International Nurse Practitioner/Advanced Practice Nursing Network (INP/ PNN). Paper-10713889.
Basic estimates on the association between DRS and salivary findings showed that microbial counts only produced significant odds ratios, from 2.0 to 3. Paper-1316773.
The kinetics of aspartyl-adenylate formation and Asp-tRNA synthesis by hDRS delta 32 were indistinguishable from those of hDRS. Paper-146230.
A slight increase in mean total HDL cholesterol vs. baseline was found for the DRSP group (+12.8%) and the DSG group (+11.8%) after 13 treatment cycles. Paper-10240879.
EE/ DRSP is equally as effective as ethinylestradiol 30microg/ desogestrel 150microg (EE/ DSG; corrected Pearl index 0.28-0.41) in preventing pregnancy. Paper-10670044.
memA/ DRS, a putative mediator of multiprotein complexes, is overexpressed in the metastasizing human melanoma cell lines BLM and MV3. Paper-1817036.
COS cells transfected with pSV-hDRS delta 32 that contained N-terminal 32 residue-coding sequence deleted hDRS cDNA showed no increase in DRS activity. Paper-174902.
Point mutation analyses revealed two essential residues within the pinin fragment 1-98, leucine 8 and leucine 19, for the interaction with keratin. Paper-8355202.
Stabilizing hormone levels with EE/ DRSP may provide an important therapeutic option for women taking antidepressants whose symptoms break through premenstrually. Paper-12653766.
CONCLUSION: This study provides preliminary evidence that addition of EE/ DRSP (+/- EE) to antidepressants may treat premenstrual breakthrough of depression. Paper-12653766.
The Michaelis-Menten constants for aspartic acid and tRNAAsp were 302 microM and 13 nM for hDRS, and 29 microM and 130 nM for hDRS delta 32, respectively. Paper-85465.
An ICL DRS 20/50 network of four microcomputers has been installed in the obstetric unit of a district teaching hospital with a link to the regional mainframe. Paper-5061201.
It contains 3 mg drospirenone, a progestogen resembling endogenous progesterone, and 30 microg ethinylestradiol ( DRSP/EE, Yasmin, Schering AG, Berlin, Germany). Paper-10687587.
Microvilli- and desmosome-associated bodies in Crohn's disease and other disorders in childhood: an ultrastructural abnormality of the small and large intestine. Paper-4637497.
Drospirenone ( DRSP: 6beta,7beta,15beta,16beta-dimethylene-3-oxo 17alpha-pregn-4-ene-21,17 carbolactone) is the first synthetic progestin with antialdosterone activity. Paper-10174693.
TNF-alpha did not alter the KILLER/ DR5 mRNA stability, suggesting that the TNF-alpha regulation of KILLER/ DRS expression appears transcriptional. Paper-1413054.
Endemic pemphigus foliaceus, or fogo selvagem, is an autoimmune blistering skin disease caused by IgG autoantibodies to a desmosome-associated glycoprotein. Paper-6269357.
Cell death induced by IFNs and Apo2L can be blocked by a dominant-negative Apo2L receptor, DRS, and is regulated by members of the Bcl-2 family of proteins. Paper-9938440.
Expression of memA mRNA is elevated in the highly metastasizing human melanoma cell lines and derived xenografts, as compared with the non-metastasizing ones. Paper-1817036.
Antibodies differentiate desmosome-form and nucleus-form pinin: evidence that pinin is a moonlighting protein with dual location at the desmosome and within the nucleus. Paper-2019894.
CONCLUSION: The betadex clathrate formulation of EE, when combined with DRSP, does not affect the pharmacokinetics and relative bioavailability of either EE or drsp. Paper-12744428.
Ethinylestradiol 30microg/drospirenone 3mg (Yasmin, petibelle) [EE/ DRSP] is a combined contraceptive pill (CC) for the prevention of pregnancy in women of reproductive age. Paper-10670044.
In conclusion, use of the DRS showed it possible to evaluate the protective efficacy of beta 2-adrenergic agonists against induced bronchoconstriction in healthy subjects. Paper-6534096.
Recently a protein, claimed to be localized exclusively in the nucleus, however, with amino acid sequence identical to pinin, was reported (E. J. Cell Biol. (1998) 75, 295-298). Paper-2019894.
This is the first trial of a unique oral contraceptive containing a combination of drospirenone ( DRSP, 3 mg) and ethinyl estradiol ( EE, 30 microg) for the treatment of PMDD. Paper-9056750.
We have identified a protein named pinin that is associated with the mature desmosomes of the epithelia (Ouyang, P., and S.P. Sugrue. 1992. J. Cell Biol. 118:1477-1488). Paper-800468.
The study was conducted to investigate the relative bioavailability and pharmacokinetic parameters of EE and drsp after oral administration of EE-betadex clathrate/ drsp. Paper-12744428.
This article chronicles the development of the perinatal nurse practitioner ( PNNP) role in providing care to high-risk obstetric patients in ambulatory and inpatient settings. Paper-608439.
memA was isolated by subtractive hybridization in which the mRNA repertoire was compared in a panel of human melanoma cell lines with different metastasizing potential. Paper-1817036.
Gel filtration analysis showed that hDRS in pSV-hDRS transfected cells expressed as a low molecular weight form of hDRS and pSV-hDRS delta 32 transfected cells did not. Paper-174902.
Patients treated with DRSP/ EE showed a numerically greater change from baseline compared with those treated with placebo on each of the 22 COPE items and each of the 4 symptom factors. Paper-9056750.
CONCLUSIONS: The E2 1mg/ DRSP 2mg combination tested in the study was efficacious and safe in the treatment of hot flushes and other climacteric symptoms in postmenopausal Korean women. Paper-13344774.
In particular, items reflecting attention, initiation and perseveration, conceptualization, and memory tasks on the DRS distinguished between those with and without severe sleep apnea. Paper-6960661.
Participants were randomly assigned to treatment with 1.0 mg of estradiol alone (E(2) monotherapy) or 1.0 mg of estradiol plus 0.5, 1.0, 2.0, or 3.0 mg of drospirenone ( DRSP/E(2)). Paper-11794603.
Targeting desmosome signaling via inhibition of p38MAPK and HSP27 phosphorylation may provide novel treatments for PV and other desmosome-associated blistering diseases. Paper-11171225.
Expression of the full-length cDNA clones in human 293 cells and monkey COS-7 cells demonstrated that a 140-kD immunoreactive species on Western blots corresponded to pinin. Paper-800468.
Both active ingredients of the new contraceptive EE/ DRSP showed accumulation within a treatment cycle, which is also the case with other synthetic progestogen/ ethinylestradiol combinations. Paper-8737991.
CONCLUSION: EE/ DRSP initiators are no more likely than other OC initiators to experience hyperkalemia or related clinical outcomes which could be caused by hyperkalemia during follow-up. Paper-13045129.
Furthermore, methylation analyses revealed that aberrant methylation of pinin CpG islands was correlated with decreased/absent pinin expression in a subset of tumor tissues. Paper-2096512.
The results of this study show a consistent trend in the reduction of symptoms that suggested a beneficial effect of DRSP/ EE for the treatment of PMDD, despite limitations of the study design. Paper-9056750.
A similar improvement in skin condition (acne, seborrhea) was observed in women receiving EE/ DRSP or ethinylestradiol 35microg/cyproterone acetate 2mg in a randomized, double-blind trial. Paper-10670044.
The Test for Severe Impairment (TSI; Albert & Cohen, 1992) was compared to the Dementia Rating Scale ( DRS; Mattis, 1988) on nursing home patients identified with cognitive impairment. Paper-8311804.
Moreover, although the TSI was a test designed for late stage assessment, it is a comparable measure with the DRS and can be used across the different levels of cognitive impairment in dementia. Paper-8311804.
Extra-framework aluminium species, formed upon expulsion of aluminium from the framework, are detected by DRS because they are involved in aluminium-oxygen charge transfer transitions. Paper-8721490.
The utility of this methodology in facilitating the application of the WVPC and PPC-2, and the potential of the DRS as a multiple baseline measure in treatment outcome research is discussed. Paper-1496451.
There were six cases of drug-resistant S. pneumoniae ( DRSP) infection; 3 cases of meningitis, one case of pneumonia, one case of infective endocarditis and one case of purpura fulminans. Paper-8912669.
At 1-3mg DRSP per animal per day subcutaneously, pregnancy maintenance after ovariectomy, antiovulatory activity, and antimineralocorticoid activity were seen in the respective assays in rats. Paper-10174693.
Objectives To evaluate the effect of a 30-mug ethinyloestradiol and 3-mg drospirenone (EE 30 mug/ drsp 3 mg) combined oral contraceptive (COC) on the quality of life (QoL) and sexual functioning. Paper-12747294.
The prevalence of MRSA and DRSP among healthy children colonized with SA or SP is low in this population of children attending a university-based ambulatory care centre in the United States. Paper-10384257.
In the absence of propylene glycol, hDRS bound to amino-hexyl-agarose weaker than hDRS delta 32, but, in the presence of 50% propylene glycol, hDRS bound tighter than hDRS delta 32. Paper-85465.
Pearson correlations between composite and total DRS scores were highly significant (p<.001) for all domains and the global index score, with the exception of delayed memory, which showed a floor effect. Paper-9987000.
Dynamic expression of pemphigus antigens by cultured human and mouse keratinocytes was compared with that of desmosome-associated molecules and cellular markers relating to epidermal differentiation. Paper-7571369.
RESULTS: The relative bioavailability of EE and drsp after EE-betadex clathrate/ drsp tablet administration was comparable with that achieved with the EE/ drsp tablet (107% and 101%, respectively). Paper-12744428.
BACKGROUND: The oral contraceptive ethinyl estradiol 0.03 mg/drospirenone 3 mg (EE/ DRSP) contains a progestin component that possesses potassium-sparing diuretic activity similar to spironolactone. Paper-13045129.
BACKGROUND: Ethinyl estradiol 0.03 mg/drospirenone 3 mg (EE/ DRSP) contains a progestin drospirenone with antimineralocorticoid properties that may cause potassium retention leading to hyperkalemia. Paper-12563072.
Thus, there are physical attributes of SR and SR-like substrates that dictate the mechanism of phosphorylation, whereas the ability to processively phosphorylate substrates is inherent to SR protein kinases. Paper-13372816.
CONCLUSION: This study demonstrates incomplete physician compliance with a labeling recommendation of potassium monitoring for initiators of EE/ DRSP receiving concomitant therapy predisposing to hyperkalemia. Paper-12433971.
In this work, the thermotropic phase behaviour of T12 has been studied by means of various techniques, namely, DSC, FTIR and FT-Raman spectroscopy, X-ray powder diffraction, and DRS. Paper-10542234.
We investigate the connections between two field-enhanced phenomena of gold nanoparticles: multiphoton-absorption-induced luminescence (MAIL) and metal-enhanced multiphoton absorption polymerization ( MEMAP). Paper-13721386.
Northern blots of mRNA from chicken corneal epithelium, MDCK cells, and various human tissues indicated that pinin messages exhibit tissue-specific variation in size, ranging from 3.2 to 4.1 kb. Paper-800468.
These results from clinical trials with EE/ DRSP indicate that it is a well-tolerated combined oral contraceptive that has a positive effect on body weight, skin and the symptoms of premenstrual syndrome. Paper-8737986.
These catalysts were characterized using various physicochemical techniques (BET, NO chemisorption, DRS, LRS, TPR, and XPS), and their catalytic activity for the hydrodesulfurization of thiophene was determined. Paper-10022594.
Results QoL indices for women using EE 30 mug/ drsp 3 mg scored higher than for the controls and statistically significantly so with regard to improved general health and mood (p < 0.02), and mental health (p < 0.01). Paper-12747294.
A composite clinical surrogate hyperkalemia end point occurred with equal frequency in the compared groups [118 cases in EE/ DRSP and 260 in comparators; rate ratio (RR) 0.9, 95% confidence interval (CI) 0.7-1.1]. Paper-13045129.
The women received single oral doses of 40 mcg EE/6 mg drsp formulated as EE-betadex clathrate/ drsp or EE/ drsp (EE as a free steroid) tablets, or as a microcrystalline suspension on three separate occasions. Paper-12744428.
In addition, the d-form pinin is characterized by a dynamic transport process which involves the gradual diminishing of nuclear materials relative to enhanced anchoring of pinin to the desmosome upon mature cells. Paper-2019894.
Our previous study demonstrated that restoration of pinin expression in transformed cells not only positively influenced cellular adhesive properties but also reversed the transformed phenotype to more epithelial-like. Paper-2096512.
This reaction is catalyzed by a ruthenium complex based on a dearomatized PNN-type ligand [where PNN is 2-(di-tert-butylphosphinomethyl)-6-(diethylaminomethyl)pyridine], and no base or acid promoters are required. Paper-13382495.
A particular set of cards when dealt together could constitute Sjögren's syndrome if the hand includes cards marked for female sex, HLA DRS, anti Ro antibodies, anti La antibodies, exposure to retroviruses etc. Paper-426154.
In this double-blind, placebo-controlled trial, 82 women with PMDD ( Diagnostic and Statistical Manual of Mental Disorders, 4th ed. [ DSM IV]) were randomized to receive DRSP/ EE or placebo for three treatment cycles. Paper-9056750.
BACKGROUND: A new combined oral contraceptive formulation has been developed consisting of a beta-cyclodextrin (betadex) clathrate formulation of ethinyl estradiol in combination with drospirenone (EE-betadex clathrate/ drsp). Paper-12744428.
This protein, referred to as pNO40 based on its molecular weight on SDS-PAGE, was identified through yeast two hybrid interaction screen of a human kidney cDNA library using pinin (pnn) protein as the bait. Paper-9804747.
Pinin is a cell adhesion-associated and nuclear protein that has been shown to localize in the vicinity of intermediate filament (IF) convergence upon the cytoplasmic face of the desmosomal plaque as well as in the nucleus. Paper-8355202.
In this study, a collection of quinolone and quinoline derivatives' carcinogenicity is determined by qualitatively predicting their genotoxicity potential with predictive PNN (probabilistic neural network) classification models. Paper-10980838.
Because preliminary analyses indicated incomplete compliance, we surveyed physicians who prescribed EE/ DRSP to women receiving drugs predisposing to hyperkalemia on their knowledge and attitudes with regard to the recommendation. Paper-12433971.
The studies were performed during first and third uses of cuprammonium rayon and polysulfone dialyzers processed by rinsing with water, then bleach, in an automated system (Seratronics DRS 4) and then packed in 1.5% formaldehyde. Paper-6443398.
Previously, we have shown that pinin/ DRS (Pnn), a 140-kDa nuclear and cell adhesion-related phosphoprotein, is involved in the regulation of cell adhesion and modulation of the activity of multiple tumor suppressor genes. Paper-11423528.
Indeed, while only one phosphorus atom is coordinated to iron in ( PNN coordination), no thiophosphine moiety is connected to Fe in (NN coordination), whereas both phosphine oxide arms are linked to the metal in (ONNO) coordination. Paper-13756445.
Since 1977, the author has treated proliferative diabetic retinopathy (PDR) under a protocol using DRS-style panretinal photocoagulation (PRP), with supplemental PRP, panretinal cryotherapy, and vitrectomy as needed. Paper-4326370.
Coupled with our previous morphological observations and transfection studies, these data suggest that pinin may play a role in epithelial cell adhesion and the IF complex through a direct interaction with the keratin filaments. Paper-8355202.
Further, the XRD, FT-IR, UV-vis DRS, and XPS studies indicate the retention of the coordination geometries of the specific divalent anions anchored to LDH matrix in their monomeric form during the ion exchange and after the reaction. Paper-9769549.
CONCLUSION: DRS is a more physiologically friendly and accurate method of gastric banding adjustment than the conventional barium swallow adjustment; it also results in a better weight loss during the first 6 months after operation. Paper-10311828.
AEFV can be considered at least as good a pulmonary function variable as FEV1 in demonstrating bronchoconstriction during MPs in normal subjects, and it might even be a better variable to obtain DRS-values than other variables tested. Paper-6532822.
Methods A total of 81 non-hysterectomized postmenopausal women were allocated either to 17beta-estradiol 1 mg and norethisterone acetate 0.5 mg (E2/NETA, n = 43) or to 17beta-estradiol 1 mg and drospirenone 2 mg (E2/ DRSP, n = 38). Paper-13767382.
Furthermore, we found that the Drs protein can interact with ASY/Nogo-B/RTN-x(S), an apoptosis-inducing protein localized in the endoplasmic reticulum, and that coexpression of these genes increased the efficiency of apoptosis. Paper-10290637.
Supervised (probabilistic neural networks, PNN) and unsupervised ( principal component analysis, PCA; Kohonen neural networks; generative topographic mapping, GTM) pattern recognition techniques were used to visualize and classify samples. Paper-12390593.
Immunofluorescence staining revealed that the expressed pinin protein was assembled to the lateral boundaries of the cells in contact, which is consistent with the staining pattern of pinin in epithelial cells. Paper-800468.
The solution NMR spectroscopic and X-ray crystallographic studies are indicative of a trigonal bipyramidal geometry for these aluminium complexes in which the amino nitrogen atom is trans to the phosphorus donor of the [ PNN](-) ligand. Paper-11495340.
The Dementia Rating Scale ( DRS; Mattis, 1976, 1988) is commonly used in the assessment of dementia, although little is known about the relationship of performance on this test to specific cognitive deficits in Alzheimer's disease (AD). Paper-9987000.
The encoded amino acid sequence predicts that the MEMA protein has three coiled-coil domains, one glycine loop domain, is very hydrophilic and contains regions rich in glutamine/ proline, glutamic acid and serine residues. Paper-1817036.
In the present prospective study, digital retrograde urethrographs (Prestilix 1600X/ DRS, General Electric) were obtained in 40 consecutive male patients (mean age 60.6 years; range 23-88 years) presenting for evaluation of urinary pathology. Paper-649637.
A novel missense mutation, Arg(139)His, located in the conserved DRS motif at the junction of the third transmembrane and the second intracellular loop of the GnRH receptor was identified in the homozygous state in one female with complete HH. Paper-8985763.
Correlations with psychometric test data showed PIP rate in REM to be related to the psychoticism scale of the Minnesota Multiphasic Personality Inventory and MEMA rate in REM to be inversely related to the Barron Ego Strength scale. Paper-3184753.
The dose-response slope [ DRS = maximal fall (%) in pulmonary function/maximal non-cumulative methacholine dose (mumol)] was calculated from forced expiratory volume in 1 s (FEV1) and from area under the expiratory flow-volume curve (AEFV). Paper-6884622.
Dose response slope [ DRS = maximal percentual fall in pulmonary function/maximal noncumulative histamine dose (mumol)] was used as an index of bronchial reactivity, and was calculated for FEV1 (DRSFEV1) and area under the flow-volume curve (DRSAEFV). Paper-8013173.
PURPOSE: Yasmin-28 [ ethinyl estradiol 0.03 mg/drospirenone 3 mg (EE/ DRSP)] contains drospirenone, a progestin component that possesses antimineralocorticoid activity with a potassium-sparing diuretic effect similar to that in spironolactone. Paper-12433971.
DRSP (3 mg per day+15, 20, or 30 microg ethinyl estradiol per day) prevented the mild increase of blood pressure seen under a conventional levonorgestrel-containing contraceptive and even tended to reduce pretreatment blood pressure. Paper-10174693.
Newly emerging patterns of antibiotic resistance have altered recent guidelines for CAP treatment; DRSP is now a consideration in elderly patients because an age older than 65 years is a well-described risk factor for infection with this organism. Paper-9671230.
My last three trials were a trial of photocoagulation in diabetic retinopathy ( DRS), a six-country trial of the antiarrhythmic drug mexiletine (IMPACT), and a study involving two diagnostic procedures for pulmonary embolism (PIOPED). Paper-6457023.
METHODS: Twenty-seven women with either severe papular or nodulocystic facial acne were treated with a combined oral contraceptive containing 30 mug ethinyl estradiol and 3 mg drospirenone (EE/ DRSP; Yasmin) and spironolactone (SL) 100 mg taken daily. Paper-12671571.
In this study, we evaluated the correlation of patients' scores on Mattis' Dementia Rating Scale ( DRS; total and subscale scores) with scores on the Medication Management Ability Assessment (MMAA), a performance-based measure of medication management. Paper-9969928.
The risk of severe visual loss rose with increasing NVD, hemorrhages/microaneurysms, retinal elevation, proteinuria, and hyperglycemia and fell with increasing "treatment density." These results are similar to previous DRS findings on untreated eyes. Paper-6187533.
The probability of hyperplasia was 0.060 (95% CI, 0.043-0.078) for the E(2) monotherapy group, 0.007 for the 2-mg DRSP/E(2) group, and nonsignificant for the remaining drospirenone/ estradiol groups.Endometrial bleeding decreased in all treatment groups over time. Paper-11794603.
The incidence of intermenstrual bleeding (spotting, breakthrough bleeding or both) during treatment with EE/ DRSP in young, healthy women decreased rapidly after the first cycle to 9 to 18% in the second cycle and 6% after 26 cycles, indicating good cycle control. Paper-10670044.
The N-terminal region containing the serine-rich (S) domain, the central RNA recognition motif (RRM), and the C-terminal arginine/ serine/ proline-rich (RS/P) domain of RNPS1 interact with p54, pinin, and hTra2 beta, respectively. Paper-10206578.
The preliminary document WHO/ CDC/ CSR/ DRS/2000.I Draft has already been distributed, and remarks have been solicited.<br /> The World Health Assembly Resolution of 1998 urged Member States to encourage the appropriate and cost-effective use of antimicrobials. Paper-12553626.
METHODS: We evaluated compliance with this recommendation by measuring monitoring around the date of oral contraceptive (OC) initiation in women who received EE/ DRSP while being treated with medications predisposing to hyperkalemia and in similar women who received other OCs. Paper-12433971.
2. NVD are the single most important prognostic feature of diabetic retinopathy, and when they are well established (i.e., greater than or equal to DRS Standard Photograph 10A), the indication for initiation of scatter photocoagulation is strong (Cases 7, 8, 10, and 11). Paper-11952389.
The absence of hyperphenylalaninemia and the presence of normal urinary pterin metabolites and of normal SR-like activity in red blood cells may be explained by alternative pathways for the final two-step reaction of BH(4) biosynthesis in peripheral and neuronal tissues. Paper-9017302.
The activity of the studied catalysts is well correlated with the intensity of a DRS absorption band that appeared at ca. 400 nm, which is considered as a measure of the magnitude of interactions exerted between the monolayer transition metal-oxo species and the TiO2 carrier. Paper-11430603.
Studies have suggested that rates of dysmenorrhea improved in women taking DRSP/EE as well as in women using an oral contraceptive containing 30 microg ethinylestradiol and desogestrel, but symptoms were more often mild or less often severe in the DRSP/EE group. Paper-10687587.
Because DRS and LSS provide complementary information to each other and to other spectroscopic modalities, such as fluorescence, it is possible that a combination of all these techniques will ultimately provide a highly accurate real-time method for detecting BE dysplasia. Paper-9938299.
STUDY DESIGN: This was a single-center prospective analysis of self-rated menstrual flow during a 21/7-day versus a 168-day extended regimen of on OC containing 3 mg of drosperinone and 30 mcg of ethinyl estradiol ( DRSP/EE) with institution of a randomized protocol to manage BTB/ BTS. Paper-12244867.
Dose response "slope" ( DRS = maximum percentage fall in pulmonary function/maximal noncumulative methacholine dose (mumols] was used as an index of bronchial reactivity, and was calculated for forced expiratory flow volume in 1 s (DRSFEV1) and area under the flow-volume curve (DRSAEFV). Paper-6534096.
These results showed that hDRS has little tendency to aggregate in vivo and suggested that the N-terminal extension in hDRS was not involved in the expression and sub-cellular localization of hDRS, but may play a role in the maintenance of enzymatic activity of hDRS in COS cells. Paper-174902.
After transfection of COS cells with the recombinant plasmids pSVL-63 that contained hDRS cDNA coding and non-coding sequences, and pSV-hDRS where the non-coding sequences were deleted, DRS in the transfected COS cells significantly increased compared to mock transfected cells. Paper-174902.
In contrast, 3-year interim results from a large, controlled, prospective postmarketing surveillance study suggest a VTE rate of 61/100 000 women-years for EE/ DRSP, which is similar to the rates of 60/100 000 and 73/100 000 women-years for levonorgestrel-containing OCs and other OCs, respectively. Paper-11413697.
On the contrary, data pooled from homogeneous populations of post-MI patients from DRS, MDPIT, DAVIT-I, and DAVIT-II indicate that clinical outcomes are favorably influenced in patients recovering from non-Q wave MI, and in hypertensive post-MI patients with preserved left ventricular function. Paper-907949.
Because of the rapidly emerging resistance of Streptococcus pneumoniae (SP) infections to penicillin and other antimicrobial agents, the Drug-Resistant Streptococcus pneumoniae Working Group (DRSPWG) was established in 1993 to develop a strategy to minimize the impact of drug-resistant SP ( DRSP). Paper-11683537.
METHOD: Eighty women (mean age, 24.6 years) were randomized into three groups and given one of the following contraceptive methods: ethinylestradiol 15 mug/gestodene 60 mug (EE/ GST, n=25), ethinylestradiol 30 mug/drospirenone 3 mg (EE/ DRS, n=29) or male condom ( control group, n=26). Paper-11312766.
STUDY DESIGN: This was a single center prospective analysis of the single item Scott and White (S&W) Mood Scale and the Penn State Daily Symptom Report (DSR17) during a 21/7-day followed by a 168-day extended regimen of an OC containing 3 mg of drosperinone and 30 microg of ethinyl estradiol ( DRSP/EE). Paper-12298104.
Previous work from our group showed that intrathecal (i.t.) administration of substances such as glutamate, NMDA, or PGE(2) induced sensitization of the primary nociceptive neuron ( PNN hypernociception) that was inhibited by a distal intraplantar (i.pl.) injection of either morphine or dipyrone. Paper-13501425.
This asked women who had been involved in two major clinical trials how they felt after these trials had ended, in comparison with the study periods when they were taking EE/ DRSP or a combined oral contraceptive containing 30 microg ethinylestradiol/150 microg desogestrel ( Marvelon, EE/ DSG). Paper-8737986.
As DRSP continues to spread and resistant strains with penicillin MIC >2 mg/L become more prevalent, new agents such as the azabicyclo-methoxyquinolone, moxifloxacin, and perhaps grepafloxacin, but not the more toxic sparfloxacin and trovafloxacin, will undoubtedly flourish as treatments for CAP. Paper-1946816.
This study compared the efficacy of a low-dose combined oral contraceptive (COC) containing 3-mg drospirenone and 20-microg ethinyl estradiol (3-mg DRSP/20-microg EE) administered in a 24-day active pill/4-day inert pill (24/4) regimen and placebo in women with moderate acne vulgaris during 6 treatment cycles. Paper-12948153.
OBJECTIVES: The aim of this study was to demonstrate that the therapeutic efficacy of an estradiol 1mg/drospirenone 2mg (E2/ DRSP) preparation is superior to a placebo in postmenopausal Korean women with hot flushes and other climacteric symptoms, and to demonstrate that this treatment is both safe and tolerable. Paper-13344774.
Reaction of the electron-rich, bulky tridentate PNN ligand (PNN=2-di-tert-butylphosphinomethyl-6-diethylaminomethylpyridine) with Ru(PPh3)3Cl2 at 65 degrees C resulted in formation of the mononuclear dinitrogen complex (PNN)Ru(Cl)2N2 (minor) and the N2 bridged Ru(II) dinuclear complex [(PNN)Ru(Cl)2]2(micro-N2) (major). Paper-12373655.
Older adults with epilepsy who were receiving antiepileptic drug (AED) polytherapy (n=11) displayed worse performance on the attention, initiation/perseveration, and memory subscales of the DRS and Logical Memory delayed recall score compared with those older adults with epilepsy receiving monotherapy (n=14). Paper-11216723.
The effect of level of cognitive impairment (as measured by the MMSE and Mattis DRS), demographic characteristics (e.g., education and age), behavioral problems (e.g., agitation), and co-existent health problems (e.g., vascular disease) on rate of decline was investigated via multivariate regression analysis. Paper-148646.
We estimated the percentage of EE/ DRSP users prescribed concomitant potassium-sparing drugs [nonsteroidal antiinflammatory drugs, diuretics, angiotensin-converting enzyme inhibitors (with diuretics), angiotensin II agonists (with diuretics), and potassium chloride] between January 1, 2002, and March 31, 2005. Paper-12563072.
In a collection of human tumor cell lines and melanoma metastasis lesions, memA mRNA expression could be detected in the A-431 ( epidermoid carcinoma), HT-1080 ( fibrosarcoma), JEG-3 and JAR ( choriocarcinomas) cell lines and in three out of 11 melanoma metastasis lesions. Paper-1817036.
Although the desmosome-form (d-form) and the nucleus-form (n-form) pinin share identical amino acid sequences as demonstrated by cDNA library screening and DNA sequencing, they exhibit remarkably different biochemical properties, reflecting the apparent different multiprotein nature of their differential cellular locations. Paper-2019894.
In this open-label, randomized study we compared the influence of a new oral contraceptive containing 30 microg ethinylestradiol and 3 mg drospirenone (EE + DRSP = Yasmin), with a reference preparation containing 30 microg ethinylestradiol and 150 microg desogestrel (EE + DSG = Marvelon) on the lipid profile. Paper-10240879.
Therefore, pinin may play a significant role in reinforcing the intermediate filament-desmosome complex. cDNA clones coding for pinin were identified, using degenerative oligonucleotide probes that were based on the internal amino acid sequence of pinin for the screening of a cDNA library. Paper-800468.
1. Although the presence of DRS high-risk characteristics is the single most important indication for initiating scatter photocoagulation, intraretinal lesions suggesting ischemia (soft exudates, IRMA, venous beading, arteriolar abnormalities, and moderately severe hemorrhages and/or microaneurysms) are also important. Paper-11952389.
Dendritic reticulum cells and their desmosome-associated processes, characteristic of germinal centers, were observed in all 11 cases of nodular poorly differentiated lymphocytic lymphoma and in one of two cases of nodular "histiocytic" lymphoma, but were not identified in the lymphomas with a diffuse growth pattern. Paper-3406109.
Clearly, as discussed elsewhere in this supplement, the continuing validity of these 20-year-old conclusions and the global prevalence of DRSP demand the development and marketing of new conjugate vaccines, although more widespread use of the existing 23-valent polysaccharide vaccine among high-risk populations is essential in the interim. Paper-1946816.
Although a correlation exists between the tyrosine phosphorylation of the adherens junction protein beta-catenin and loss of classical cadherin-mediated adhesion, the effects of tyrosine phosphorylation on the function of the adherens junction and desmosome-associated protein plakoglobin is unknown. Paper-9008662.
CONCLUSION: The percentage of drug resistant Streptococcus pneumoniae was negligible in Karachi during the study period, however it is important to monitor the susceptibility pattern to keep a check on an increase in the number of DRSP as reported at different centres in Turkey, Saudi Arabia, Singapore, Thailand, Hong Kong and Indonesia. Paper-2199839.
A protein recently described as a desmosome-specific molecule involved in anchoring intermediate-sized filaments (IFs) to the desmosomal plaque, and hence named " pinin" [43], has been known in our laboratory for several years as a strictly nuclear protein occurring in a wide range of cell types, including many that are totally devoid of desmosomes. Paper-1304461.
Human aspartyl-tRNA synthetase ( hDRS) and an N-terminal 32-residue truncated form of human aspartyl-tRNA synthetase ( hDRS delta 32) were expressed in Escherichia coli under the control of the inducible tac promoter as glutathione-S-transferase ( GST) fusion proteins linked through a thrombin cleavage site. Paper-85465.
When respiratory infections occur, rapid diagnosis and prompt, empirical administration of appropriate antibacterial therapy that ensures adequate coverage of DRSP is likely to increase the probability of a successful outcome when treating community-acquired pneumonia in elderly patients, particularly those with multiple risk factors for DRSP. Paper-10918320.
Kaplan-Meier (KM) DFI curves were calculated for any relapse defined as a local, regional, contralateral, or distant breast cancer event for the six predefined breast cancer subgroups: ER + PR + HER-2 - ( PPN), ER + PR - HER-2 - ( PNN), ER + PR + HER-2 + (PPP), ER - PR - HER-2 - (NNN), ER - PR - HER-2 + (NNP), and ER + PR - HER-2 + ( PNP). Paper-13527634.
DFT calculations (B3LYP/6-311+G(3df,2p)//B3LYP/6-31G(d,p)) are used to evaluate the bonding, ground-state structures, and energy landscape for the different isomers of 3: the thermodynamics and kinetics of the successive elimination of chlorotrimethylsilane (TMS-Cl) resulting in the formation of covalent azide analogues such as TMS- PNN or TMS-NNP. Paper-11006055.
From our results we conclude that this nuclear protein, characterized by a domain exceptionally rich in serine residues and hence termed DRS-protein, occurs in at least two genetically different forms in a diffusible state as well as in special ribonucleoprotein-particles, "speckles" [6], and is a widespread if not ubiquitous nuclear protein. Paper-1304461.
These synonyms are used for gene PNN (pinin, desmosome associated protein): SR-like protein, SDK3, Pinin, pinin, Nuclear protein SDK3, MEMA, memA, Melanoma metastasis clone A protein, DRS protein, DRSP, DRS, Domain-rich serine protein, Desmosome-associated protein, 140 kDa nuclear and cell adhesion-related phosphoprotein.
These accession numbers are used for gene PNN: Q6P5X4 (UNIPROT__AC), BAD97332 (NCBI_GENBANK__AC), B4DZX8 (UNIPROT__AC), AAH62602 (NCBI_GENBANK__AC).
PNN is a homologue of R186.7 (hypothetical protein) from Caenorhabditis elegans.
PNN is a homologue of PNN (pinin, desmosome associated protein) from Bos taurus.
PNN is a homologue of PNN (pinin, desmosome associated protein) from Pan troglodytes.
PNN is a homologue of PNN (pinin, desmosome associated protein) from Gallus gallus.
PNN is a homologue of PNN (pinin, desmosome associated protein) from Canis lupus familiaris.
PNN is a homologue of Pnn (pinin) from Mus musculus.
PNN is a homologue of Pnn (Pinin) from Drosophila melanogaster.
PNN is a homologue of Pnn (pinin, desmosome associated protein) from Rattus norvegicus.
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iHOP - Information Hyperlinked over Proteins .
Concept & Implementation by Robert Hoffmann.