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Pregnancy-associated major basic protein in amniotic fluid. Paper-7239282.
This parallels the late rise in MBP seen in humans in the third trimester. Paper-7433411.
Neither MBP1 nor MBP2 could be detected in any other peripheral blood leukocyte. Paper-14713261.
Analysis of pregnancy-associated major basic protein levels throughout gestation. Paper-7818383.
MBP increased by 5-9%, but heart rate was unchanged throughout immersion. Paper-8009222.
In 15 patient hospitalized for asthma, MBP levels of sputum were markedly elevated. Paper-3741694.
MBP was extracted from human eosinophils and purified by size-exclusion HPLC. Paper-7479969.
Here, plasma MBP levels were measured throughout gestation in cynomolgus monkeys. Paper-7433411.
Milk basic protein ( MBP) increases radial bone mineral density in healthy adult women. Paper-9234951.
EMBP was found to be expressed predominantly in the moderately differentiated carcinomas. Paper-5800635.
Furthermore, there were great individual differences in the intensity of MBP deposition. Paper-2179303.
Extracellular MBP in the mucin was strikingly greater than intact eosinophil staining. Paper-8473455.
The eosinophil granule major basic protein ( MBP) is toxic to parasites and mammalian cells. Paper-3741694.
Overexpression of MBP-1 induces cell death in a number of cancer cells and regresses tumor growth. Paper-13032698.
Serum levels of major basic protein ( MBP) were measured in patients with atopic dermatitis (AD). Paper-577429.
The pro- MBP subunit contains 12 cysteine residues, of which 10 have been accounted for. Paper-9723886.
Finally, a molecule indistinguishable from eosinophil granule MBP is found in the human placenta. Paper-5187846.
Prior observations have indicated that an elevated sputum level of MBP is associated with asthma. Paper-4674992.
During the final one-third of gestation, striking increases in plasma MBP occurred in the monkeys. Paper-7433411.
RESULT(S): Major basic protein ( MBP) is found in several ovarian cell types throughout the menstrual cycle. Paper-9681705.
Pregnancy-associated major basic protein ( pMBP) is a marker for placental intermediate trophoblast. Paper-1339882.
Lymph nodes from patients without Hodgkin's disease showed no extracellular deposition of MBP. Paper-5424797.
MBP levels and eosinophil survival enhancing activity were assayed in sera from three patients. Paper-615699.
The 12- to 14-kDa eosinophil major basic protein ( MBP) is primarily translated as 25-kDa pro- MBP. Paper-1164568.
Peak sputum MBP levels approximate concentrations toxic to respiratory epithelium in vitro. Paper-5169575.
In either event, there is a strong association between deposition of eosinophil granule MBP and cutaneous oedema. Paper-5187846.
We found that MBP damaged bronchial epithelium in vitro and produced changes that mimicked those in asthma. Paper-3741694.
PG-induced T cell responses decline with age, whereas there is a shift toward Th1 cytokines. Paper-13867111.
MBP (Version 1.0): A Software Package to Optimize Maize Breeding Procedures Based on Doubled Haploid Lines. Paper-12762784.
Knockdown of MBP-1 in human foreskin fibroblasts induces p53- p21 dependent senescence. Paper-13032698.
These cells were confirmed to be eosinophils by means of specific staining with antibody to major basic protein ( MBP). Paper-1187060.
MBP staining of nasal polyps showed a predominantly cellular pattern with focal areas of extracellular deposition. Paper-8473455.
Sputum MBP was not elevated in patients with bronchopulmonary infections unless acute asthma was also present. Paper-4674992.
The MBP-mediated damage to the respiratory epithelium consists of desquamation and frank destruction of ciliated cells. Paper-5169575.
Eighty percent of patients with acute optic neuritis have CSF- MBP levels greater than 6.2 ng/ml (mean 7.6 ng/ml CSF). Paper-4325404.
We analyzed placental tissue, serum, amniotic fluid, and placental cyst fluid for pregnancy-associated major basic protein. Paper-7368488.
Extracellular MBP diffusion, the hallmark of eosinophil cytotoxicity, was recurrent on sarcolemma and endothelium. Paper-13739452.
Because eosinophilia is characteristic of asthma, we tested the effect of MBP on bronchi and assayed sputa for this protein. Paper-3741694.
In the intermediate/mature follicles, MBP was immunolocalized in theca, but not in granulosa cells except in the mature follicles. Paper-9681705.
We studied the effects of daily intake of milk basic protein ( MBP) on radial bone mineral density (BMD) in healthy adult women. Paper-9234951.
Expression of estramustine-binding protein ( EMBP) and the proliferation- associated antigen Ki-67 in prostatic carcinomas. Paper-5800635.
Coupling of MBP fusion protein cleavage with sparse matrix crystallization screens to overcome problematic protein solubility. Paper-11216267.
MBP1 is more abundant than MBP2 in lysates of eosinophils and their granules, as judged by immunoassay and Western blotting. Paper-14713261.
Accordingly, interactions between human eosinophil MBP and guinea-pig airway epithelium were quantitated biochemically. Paper-7479969.
Placental site trophoblastic tumor: human placental lactogen and pregnancy-associated major basic protein as immunohistologic markers. Paper-1339882.
The object of this study was to examine the effect of MBP on the bone mineral density and bone metabolism of healthy young women. Paper-13103144.
Thus, pMBP is a useful marker for intermediate trophoblast tumors and could help distinguish these from other forms of trophoblastic disease. Paper-1339882.
These findings suggested that pro- MBP could be used as a marker for proliferation of immature granulocytes with normal or malignant nature. Paper-1164568.
A total of 112 amniotic fluids were tested and all but three contained levels of pregnancy-associated major basic protein greater than 400 ng/ml. Paper-7239282.
Thus, the cynomolgus monkey may serve as a model to clarify the role of the MBP in the biochemical events that culminate in parturition. Paper-7433411.
RESULTS.: The linear regression fit of [Na] versus [ PG] data yielded a significant linear correlation coefficient of 0.71. Paper-14184290.
Together, these results demonstrated that knockdown of endogenous MBP-1 is involved in cellular senescence of HFF through p53- p21 pathway. Paper-13032698.
Duodenal biopsy specimens were obtained and studied by immunostaining for the eosinophil major basic protein ( MBP), IgE, and CD3+ T cells. Paper-9777651.
Serum pregnancy-associated major basic protein levels were variable and likely cannot be used to predict the occurrence of maternal floor infarction. Paper-7368488.
Systemic immunization of BALB/c mice with human cartilage proteoglycan ( PG) aggrecan induces progressive polyarthritis. Paper-10755711.
These results suggest that MBP promoted bone formation and suppressed bone resorption, while maintaining the balance of bone remodeling. Paper-9104339.
We developed MBP (version 1.0), a software package for optimizing maize ( Zea mays L.) breeding procedures based on doubled haploid lines. Paper-12762784.
Duodenal increases of MBP+ eosinophils and IgE-bearing cells were found in the patients during the birch pollen season as compared with off-season. Paper-9777651.
In the lungs of patients who had died of asthma, MBP has been localized outside of the eosinophil in association with damage to the epithelium. Paper-5169575.
Proteinase inhibition by proform of eosinophil major basic protein (pro- MBP) is a multistep process of intra- and intermolecular disulfide rearrangements. Paper-11006652.
Mean finger arterial blood pressure ( MBP) decreased by 34.0 +/- 1.8% at the elevated position and increased by 39.9 +/- 3.3% at the lowered position. Paper-8009222.
BACKGROUND/AIMS: Eosinophil cytoplasmic granules contain major basic protein ( MBP), which is primarily translated from its precursor, proMBP. Paper-13549175.
To unravel the role of endogenous MBP-1, we knocked down MBP-1 expression in primary human foreskin fibroblasts (HFF) by RNA interference. Paper-13032698.
The eosinophil granule proteins ( ECP and MBP) were found in the epithelium and substantia propria in patients with subacute conjunctivitis. Paper-1426181.
We first confirmed that we could measure eosinophil counts accurately in peripheral blood using alpha-major basic protein ( MBP) immunofluorescent staining. Paper-8281968.
Using an oligonucleotide probe corresponding to the partial amino acid sequence of BMPG, we cloned, sequenced, and expressed a cDNA for BMPG. Paper-7340321.
The regulatory/activated T cell ratio decreases in older mice after PG injections indicating impaired regulation of the immune response. Paper-13867111.
MBP is cytotoxic to parasites and numerous mammalian cells and is a potent secretagogue for platelets, basophils, mast cells, and neutrophils. Paper-7943823.
A bone marrow proteoglycan ( BMPG) has been purified which consists of the same amino acid sequence as that of pro-MBP, and produced two anti- BMPG mAbs. Paper-8017747.
HL-60, a promyelocytic leukemia cell line, produces pro- MBP but not MBP, suggesting production of pro- MBP by immature granulocytes. Paper-1164568.
A fusion protein MBPVP4 containing the VP4 insert of CVB4E2 and a control fusion protein MBP-beta-gal-alpha, were produced in Escherichia coli K12 TB1. Paper-13197910.
We have purified a novel immunoregulatory factor ( BMPG: bone-marrow proteoglycan) produced by a T-cell hybridoma, with a monoclonal antibody column. Paper-7340321.
BACKGROUND: The human eosinophil-granule major basic protein ( MBP) is a 13.8-kilodalton cationic polypeptide constituting the core of the eosinophil granule. Paper-7943823.
The toxic effects of the human eosinophil granule major basic protein ( MBP), reduced and alkylated, were studied on human nasal mucosa in vitro. Paper-6698108.
A study involving stimulation of rabbit disc cells with LIPUS revealed upregulation of cell proliferation and proteoglycan ( PG) synthesis. Paper-13887750.
The luteal tissue is the major site of MBP and PAPP-A with highest intensity found during the midluteal phase associated with both small and large luteal cells. Paper-9681705.
By immunofluorescence, MBP1 is present in eosinophils, basophils, and a human mast cell line (HMC1), whereas MBP2 is only detected in eosinophils. Paper-14713261.
An antibody was demonstrated in the serum of 166 out of 200 patients with MS which enabled normal lymphocytes to develop a cytotoxic (ADLC) reaction against MBP. Paper-3552026.
We utilized immunofluorescence to localize MBP in eosinophils and at sites of degranulation to study specimens from 2 fatal cases of B. procyonis infection. Paper-6264900.
In vitro, the eosinophil granule major basic protein ( MBP) is toxic to helminths and to mammalian cells, including human respiratory epithelium. Paper-5169575.
OBJECTIVES: To assess the effects of the BPP when compared with conventional monitoring (CTG only or MBPP) on pregnancy outcome in high-risk pregnancies. Paper-12726432.
Five of 7 patients with acute internuclear ophthalmoplegia due to an initial exacerbation of demyelination have CSF- MBP levels above 6.2 ng/ml (mean 6.8 ng/ml). Paper-4325404.
We conclude that a strong MBP deposition seems to occur in acute lesions of those patients with atopic dermatitis who have a predisposition to respiratory atopy. Paper-2179303.
CONCLUSION: Eosinophil proteins such as MBP and EPO inhibit mucin release from primary HTSE cells without causing any apparent cytotoxicity. Paper-1993269.
We have recently reported that human pregnancy is characterized by a 10- to 20-fold elevation of eosinophil major basic protein ( MBP) immunoreactivity in maternal blood. Paper-4543715.
To establish the connectivities of cysteine residues of the PAPP-A.pro- MBP complex, biochemical analyses of peptides derived from purified protein were performed. Paper-9723886.
Even after controlling for age, body mass index, gender, and 24-h systolic BP, the MBP hyper-reactive status still remained a strong predictor for LV hypertrophy. Paper-11518946.
Immunohistochemical staining intensities for pMBP and hPL correlated (r2 = +.24; P = .013), but hPL staining was mainly confined to intermediate trophoblast and was more intense. Paper-1339882.
The sera of all pregnant women contain increased amounts of a protein biochemically and immunologically similar to the eosinophil granule major basic protein ( MBP). Paper-7433411.
The pregnancy-associated major basic protein, a protein elevated in the sera of all pregnant women, is virtually identical to the eosinophil granule major basic protein. Paper-7239282.
As a consequence of studies using the eosinophil granule MBP, we are now able to postulate that eosinophils damage bronchial epithelium during the course of asthma. Paper-5187846.
Increased expression of major basic protein ( MBP) and interleukin-5(IL-5) in middle ear biopsy specimens from atopic patients with persistent otitis media with effusion. Paper-8592648.
Eosinophil granule major basic protein ( MBP), a potent cytotoxin released by eosinophils, has previously been demonstrated in conjunctiva from patients with GPC. Paper-6585296.
MBP staining showed that tissue eosinophil density and percentages in eosinophilia-associated myopathies were significantly higher than in idiopathic myositides. Paper-13739452.
Human eosinophil granule major basic protein ( MBP1) is an exceedingly basic ( isoelectric point >11) 14-kDa protein, comprising the core of the secondary eosinophil granule. Paper-14713261.
Eosinophil Major Basic Protein ( MBP) may be a potent effector in damaging airway epithelium and inducing acute (2-3 h) hyperresponsiveness to agonists in primates. Paper-7479969.
We examined eosinophil degranulation in tissues from patients infected with Baylisascaris procyonis as shown by the extracellular deposition of granule major basic protein ( MBP). Paper-6264900.
The results indicate that eosinophil granule constituents are released into the bronchi in asthma and that measurement of sputum MBP may be useful in identifying asthma. Paper-3741694.
OBJECTIVE.: To determine the existence of a linear correlation between intervertebral disc [Na] measured from sodium MRI and [ PG] measurement from DMMB assay. Paper-14184290.
Methyl 2-bromopropionate ( MBP) was added as free initiator during the brush preparation to control growth of the brushes and to monitor the polymerization kinetics. Paper-10377047.
These results indicate that MBP damages human upper respiratory epithelium, causing ciliostasis and alteration of the epithelial surface at concentrations likely achieved in vivo. Paper-6698108.
CONCLUSION.: Specificity of sodium MRI for PG in the intervertebral discs makes it a promising diagnostic tool for the earlier phase of disc degeneration. Paper-14184290.
The MBP immunostaining of ovarian follicles varied depending on the size, with primordial follicles staining in the ooplasm with a lack of staining in the granulosa and theca cells. Paper-9681705.
We immunohistochemically stained biopsy specimens from acute, non-oozing indurated erythematous lesions of atopic dermatitis with BMK-13, a monoclonal antibody which recognizes MBP. Paper-2179303.
In bronchial asthma, considerable evidence exists that the eosinophil releases granule proteins, especially the major basic protein ( MBP), which in turn mediate tissue abnormalities. Paper-7701013.
They were evaluated by measuring cell proliferation, PG synthesis, PG content, gene expression of TGFbetaR1, and TGF-beta1 concentration. Paper-12613260.
Previously, pregnancy-associated major basic protein has been localized to the placental X cell and identified at elevated levels in serum and amniotic fluid in all normal pregnancies. Paper-7368488.
Knockdown of MBP-1 in HFF (HFF-MBPsi-4) resulted in an induction of premature senescence, displayed flattened cell morphology, and increased senescence-associated beta-galactosidase activity. Paper-13032698.
Adjacent nonmucinous areas of respiratory mucosa showed predominantly cellular staining with eosinophil MBP, neutrophil elastase, and mast cell tryptase. Paper-8473455.
Indirect immunofluorescence for eosinophil granule major basic protein ( MBP), neutrophil elastase, and mast cell tryptase was performed on lesional tissue. Paper-615699.
The proteolytic activity of PAPP-A is inhibited by the proform of eosinophil major basic protein (pro- MBP), which forms a covalent 2:2 proteinase-inhibitor complex based on disulfide bonds. Paper-11006652.
Off-season, there was no significant difference between the patients and the control subjects regarding the intestinal frequencies of MBP+ eosinophils, mucosal IgE+ cells, and T cells. Paper-9777651.
With a microscope coupled with a television monitor (magnification x 2500) and videotape recorder, we investigated the effects of MBP on the mucosa and the ciliary activity of single cells. Paper-6698108.
To determine whether pregnancy-associated major basic protein is present in amniotic fluid, we examined samples from both early and late gestation by a double antibody radioimmunoassay. Paper-7239282.
These results demonstrate the ability of human eosinophils to lyse T. cruzi amastigotes extracellularly in the absence of antibody and suggest that MBP may be involved in the effect. Paper-5518677.
Increased sputum MBP concentration is a good marker for asthma, and patients treated for acute asthma have high levels of MBP in their sputa, which decrease after treatment. Paper-5169575.
The IL-1beta-induced reduction in PG synthesis and proliferation of chondrocytes cultured in alginate were counteracted by the CAT fraction at a concentration of 10 mug/ml. Paper-13811165.
Treatment with bronchodilators and glucocorticoids caused an increase peak expiratory flow rate, a reduction in blood eosinophils, and a decrease in the serum and sputum levels of MBP. Paper-3741694.
Eosinophil infiltration and degranulation in tissues from 52 patients with the TOS were examined by immunofluorescence staining for the eosinophil granule major basic protein ( MBP). Paper-6630725.
We report a case of incontinentia pigmenti and demonstrate the deposition and localization of eosinophil major basic protein ( MBP) in the vesicular stage of this neurocutaneous syndrome. Paper-6985824.
Concentrations of a molecule immunochemically similar to eosinophil granule MBP are present in maternal plasma, and MBP has been localized by immunofluorescence to placental X cells. Paper-7943823.
The lack of T cell response to the deleted epitope(s) was specific, but the overall immune response against the wild-type rhG1 domain of human PG was not significantly affected. Paper-10755711.
OBJECTIVE: To assess the expression and cellular distribution of pregnancy-associated plasma protein-A ( PAPP-A) and major basic protein ( MBP) in human ovarian tissue during the menstrual cycle. Paper-9681705.
The hypodense cells (density less than 1.082) contained significantly less MBP than normodense (density greater than 1.082) eosinophils (P less than .001) as measured by radioimmunoassay (RIA). Paper-5895376.
The G1 domain of the PG aggrecan molecule contains most of the T cell epitopes, including three immunodominant ('arthritogenic') and at least six subdominant T cell epitopes. Paper-10755711.
Eosinophil granule major basic protein 2 ( MBP2 or major basic protein homolog) is a paralog of major basic protein ( MBP1) and, similar to MBP1, is cytotoxic and cytostimulatory in vitro. Paper-13324717.
As conventional histology is likely to underestimate this leucocyte subset, MBP staining may be a useful tool in the analysis of tissue infiltration of eosinophils as a possible treatment target. Paper-13739452.
Our findings indicate that the UBM imaging system could provide two-dimensional (2-D) visual information for monitoring progressive trypsin-induced PG depletion in articular cartilage. Paper-13951364.
RESULTS: The patients with eosinophilic vasculitis had depressed serum complement levels and peripheral blood eosinophilia; MBP levels were elevated in serum and eosinophil survival was prolonged. Paper-615699.
By immunofluorescence, 77% of the PSTT specimens and 100% of the EPS specimens stained with antibodies to pMBP, and the pMBP was localized in intermediate trophoblast and surrounding extracellular areas. Paper-1339882.
MAIN OUTCOME MEASURE(S): Microscopic evaluation to assess the presence, distribution, and cellular co-localization of MBP and PAPP-A and to describe any variations in their expression during the menstrual cycle. Paper-9681705.
This study reports an ultrasound biomicroscopy (UBM) imaging approach to monitor the progressive trypsin-induced depletion of proteoglycan ( PG) and its inhibition in articular cartilage. Paper-13951364.
Three nodes of the mixed cellularity type, one node of the lymphocyte predominance type, and one lymph node of the lymphocyte depletion type showed one or two small foci of extracellular MBP deposition. Paper-5424797.
Immunofluorescent staining showed massive MBP deposition in multiple organ parenchyma including the heart, renal glomeruli, adrenal cortex, bronchioles, and other visceral organs, suggesting a causal relationship. Paper-1107405.
It specifically interacts with heterogeneous nuclear ribonucleoprotein A2, a trans-acting targeting factor that has previously been implicated in the transport of MBP mRNA in oligodendrocytes and neurons. Paper-12305073.
DESIGN: Ovarian tissues (n = 50) and corpora lutea (n = 18) were obtained from patients undergoing hysterectomy/ oophorectomy for benign conditions and tissue sections were immunostained for MBP and PAPP-A. Paper-9681705.
In the previous in vitro and in vivo studies, we have shown that milk whey protein, especially its basic protein fraction (milk basic protein [ MBP]), promoted bone formation and suppressed bone resorption. Paper-9104339.
STUDY DESIGN.: This study demonstrated the diagnostic potential of sodium (Na) magnetic resonance imaging (MRI) for noninvasive quantification of proteoglycan ( PG) in the intervertebral discs. Paper-14184290.
Thus, an elevated sputum MBP level was specifically associated with asthma, whereas an elevated CLC protein level was associated with both asthma and with bronchopulmonary infection in certain patient groups. Paper-4674992.
A protein immunologically identical to the major basic protein ( MBP) of eosinophil granules is present in the plasma of pregnant women and has been localized to human placental X cells using immunofluorescence. Paper-5519119.
STUDY DESIGN: Four groups of premolars (n = 60) were prepared using GT Rotary files and the crown-down technique and filled by the single-cone technique with AH26, AHPlus, EndoREZ, and an experimental MBP as sealer. Paper-13339742.
These data demonstrates that MBP cytotoxicity to intact epithelium can be rapidly measured in vitro, and suggests that rodent airway epithelium may be relatively resistant to the cytotoxic effects of MBP. Paper-7479969.
CONCLUSION: Serum pregnancy-associated major basic protein levels thus distinguish between benign disorders, such as pregnancy and partial and complete moles, and trophoblastic tumors, such as persistent moles and choriocarcinoma. Paper-695716.
In the PAPP-A.pro- MBP complex, two of these form the basis of both two interchain disulfide bonds between the PAPP-A and the pro- MBP subunits and two disulfide bonds responsible for pro- MBP dimerization, respectively. Paper-11006652.
Within the 2:2 complex, PAPP-A is dimerized by a single disulfide bond; pro- MBP is dimerized by two disulfides, and each PAPP-A subunit is connected to a pro- MBP subunit by two disulfide bonds. Paper-9723886.
This information raises important questions about the function of pregnancy-associated MBP because of the potential biological functions attributed to its eosinophil counterpart (namely, its potent toxic and cytostimulatory activities). Paper-7433411.
BACKGROUND: Blister formation and tissue damage in bullous pemphigoid have been attributed to the release of eosinophil granule proteins--namely, to eosinophil derived cationic protein ( ECP) and major basic protein ( MBP). Paper-1426181.
Concerning the gas pathway, anaerobic conditions considerably favour the emission of organo-metal compounds (tetra-methyl tin, di-methyl mercury, tetra-methyl lead) in both the MBP material and especially in the incineration ash. Paper-12436904.
CONCLUSION: Pregnancy-associated major basic protein, a potent cytotoxin, is localized to X cells and is deposited in close proximity to chorionic villi in maternal floor infarction and may contribute to the pathophysiology of this disorder. Paper-7368488.
BMPG was found to have unique characteristics: it has three types of sugar chains and it shows a marked homology with animal lectins including the human asialoglycoprotein receptor, chicken hepatic lectin and the homing receptor of lymphocytes. Paper-7340321.
Eosinophil degranulation shown by MBP deposition outside of eosinophils was found in six of eight nodes from patients with nodular sclerosing disease and in two of eight nodes from patients with lymphocyte depletion-type disease. Paper-5424797.
PAPP-A is secreted as a dimer of 400 kDa but circulates in pregnancy as a disulfide-bound 500-kDa 2:2 complex with the proform of eosinophil major basic protein (pro- MBP), recently shown to function as a proteinase inhibitor of PAPP-A. Paper-9723886.
Recent in vitro and in vivo studies have shown that milk whey protein, especially its basic protein fraction (milk basic protein, MBP), contains several components capable of promoting bone formation and inhibiting bone resorption. Paper-13103144.
STUDY DESIGN: We compared serum pregnancy-associated major basic protein levels in seven patient groups: nonpregnant and pregnant controls, partial moles, complete moles, persistent moles, placental-site trophoblastic tumors, and choriocarcinoma. Paper-695716.
EXPERIMENTAL DESIGN: To determine whether X cells produce MBP, the expression of MBP messenger RNA (mRNA) was investigated in placentas by Northern blot analyses and by in situ hybridization with 35S-labeled RNA probes. Paper-7943823.
METHODS: A total of 1505 patients, aged 18-85 years with American Society of Anesthesiologists grades I-III, were randomized to MBP or no MBP before open elective surgery for cancer, adenoma or diverticular disease of the colon. Paper-13257758.
Here we test the hypothesis that pregnancy-associated major basic protein is localized to the X cells in maternal floor infarction and that it contributes to the pathophysiologic features of pregnancies complicated by maternal floor infarction. Paper-7368488.
When purified preparations of the major eosinophil-derived protein major basic protein ( MBP) were studied, similar effects on epithelial cells were observed, i.e., damage (77 +/- 13% release of 51Cr) without detachment (less than 5% cell detachment). Paper-7294758.
Here we show, by immunofluorescence, that placental tissue specifically binds antibody to MBP in and around the placental X cells and placental-site giant cells and, using thin plastic sections, that placenta has no infiltrating eosinophils. Paper-4543715.
This human MBP caused modest, but statistically significant, damage to respiratory epithelium (16.4% increase in efflux of 51Cr from guinea-pig tracheal rings) after 3 h of incubation with 10(-4) M concentration, but not with lower concentrations. Paper-7479969.
We describe the laboratory and anatomic findings in a 15-year-old female with extraordinarily high circulating levels of eosinophil major basic protein ( MBP) who sustained a precipitous cardiac death secondary to a massive myocardial infarction. Paper-1107405.
Deposition of eosinophil granule major basic protein ( MBP) often occurs in acute and chronic lesions of atopic dermatitis, but it is not clear what the factors may be that are related to the MBP deposition in some skin lesions of the disease. Paper-2179303.
Lymph nodes from each of the four histologic types of Hodgkin's disease were examined for the presence of eosinophils and for eosinophil degranulation by immunofluorescent localization of eosinophil granule major basic protein ( MBP). Paper-5424797.
The X cells line the inner aspects of placental septal cysts, and the cyst fluid, obtained by aspiration, contains immunoreactive MBP at concentrations of 100 micrograms/ml, a sixfold greater concentration than the highest levels measured in maternal blood. Paper-4543715.
Sequential biopsies of delayed pressure urticaria at time 0, 20 min, 6, 12 and 24 h, showed eosinophil infiltration with extensive MBP deposition beginning at 20 min, and neutrophil infiltration with variable elastase deposition beginning at 20 min. Paper-463174.
RESULTS: Placental tissue from pregnancies complicated by maternal floor infarction had increased numbers of X cells and fibrinoid material that occupied or surrounded degenerating villi and that stained intensely for pregnancy-associated major basic protein. Paper-7368488.
RESULTS: Northern blot analyses of RNA from placental septa and villi showed the existence of a 1.0-kb RNA band that hybridized with the MBP anti-sense probe; no MBP mRNA was detected in whole blood of normal or pregnant women or in cord blood. Paper-7943823.
Sputum eosinophilia is characteristic of bronchial asthma, and sputum specimens from patients with asthma contain eosinophil-derived substances including Charcot-Leyden crystals ( CLC) and the eosinophil granule major basic protein ( MBP). Paper-4674992.
Analyses of placentas by in situ hybridization showed MBP mRNA in X cells of placental septa and anchoring villi, but not in other cellular elements such as syncytiotrophoblasts, cytotrophoblasts, villous stromal cells, and fetal endothelial cells. Paper-7943823.
Eosinophil infiltration and degranulation were found in several tissues, especially during the acute phase of the TOS, and serum MBP was significantly elevated during all phases of the disease, suggesting that eosinophils play a role in the pathogenesis of the TOS. Paper-6630725.
METHODS: Tissue specimens from 8 patients with allergic fungal sinusitis, along with 8 nasal polyp specimens from patients without allergic fungal sinusitis, were stained by using indirect immunofluorescence for eosinophil granule major basic protein ( MBP). Paper-8473455.
CONCLUSION: Patients with eosinophilic vasculitis, CTD, and hypocomplementemia show vessel wall destruction in association with vessel wall deposition of cytotoxic eosinophil granule MBP, which suggests that eosinophils mediate vascular damage in this disease process. Paper-615699.
Biopsies from dermographic lesions at time 0, 5 min, 15 min, 2 h and 24 h, showed few infiltrating eosinophils, with minimal extracellular MBP deposition, and a few infiltrating neutrophils, with minimal neutrophil elastase deposition, throughout the evolution of the lesions. Paper-463174.
CONCLUSION: These results suggested that MBP supplementation was effective in increasing BMD in young women and that this increase in BMD may be primarily mediated through the promotion of bone formation and inhibition of bone resorption by MBP supplementation. Paper-13103144.
Amniotic fluid pregnancy-associated major basic protein antigenic activity was immunochemically identical to that of the eosinophil granule major basic protein and also had identical physicochemical properties such as heat stability and the need for reduction and alkylation. Paper-7239282.
The finding of consistently smaller granules in the presence of equal or fewer granules per cell in the hypodense eosinophils may explain the lower MBP content and thus provide a morphologic basis for the low density of eosinophils in patients with the hypereosinophilic syndrome. Paper-5895376.
The presence of cytokines and the toxic eosinophil granule product major basic protein ( MBP) was investigated in nasal aspirates from children with naturally occurring virus-induced asthma exacerbations and compared with levels in nasal aspirates taken from the same children when asymptomatic. Paper-1771884.
CONCLUSIONS: MBP immunohistology on skeletal muscle, previously performed only for acute eosinophilic polymyositis, suggests that eosinophil-mediated injury of muscle cells may occur in a wider spectrum of less aggressive eosinophilia-associated myopathies than previously thought. Paper-13739452.
A strong MBP deposition was often seen in specimens from patients with atopic dermatitis who had a personal or family history of respiratory atopy, but was absent in specimens from those patients with atopic dermatitis who had neither a personal nor a family history of respiratory atopy. Paper-2179303.
Indirect immunofluorescence with affinity-chromatography purified antibody to human eosinophil granule MBP demonstrated many intact eosinophils within vesicles and scattered throughout the epidermis and dermis, and extracellular deposition of granular MBP in the tissue. Paper-6985824.
Our inability to demonstrate eosinophils in maternal blood or placental tissue, coupled with the large quantities of immunoreactive MBP highly localized in placental cysts and the chromatographic behavior of this molecule, suggest that the MBP detected in human gestation is produced by placenta. Paper-4543715.
To determine whether CLC protein was also elevated in asthma, we measured by specific radioimmunoassays the quantities of MBP and CLC protein in sputum specimens from 106 consecutive patients with various respiratory diseases and in sputum specimens from 10 patients hospitalized for asthma. Paper-4674992.
CONCLUSION(S): The expression and distinct pattern of MBP and PAPP-A cellular localization in human ovarian tissue during folliculogenesis and in luteal tissue suggest that their individual and combined actions in a cell specific fashion may play a role in growth and differentiation of theca, granulosa, and luteal cells. Paper-9681705.
BACKGROUND: We applied a new logistic curve fitting procedure to ambulatory blood pressure (ABP) recordings to determine whether the rate of increase in systolic ( SBP), mean ( MBP) and diastolic blood pressure (DBP) and heart rate (HR) in the morning is related to the level of BP in subjects. Paper-12259634.
The presence of extracellular MBP in lymph nodes of patients with Hodgkin's disease indicates that eosinophil degranulation commonly occurs and suggests that the released eosinophil granule proteins may participate in the inflammatory reaction in this disorder more extensively than is presently appreciated. Paper-5424797.
CONCLUSIONS: Given the known toxicities of eosinophil granule MBP and neutrophil elastase, their extracellular presence supports the contribution of these proteins in the pathogenesis of allergic fungal sinusitis and further indicates that eosinophil and neutrophil activation occurs in the disease. Paper-8473455.
We investigated the ultrastructural characteristics and the granule major basic protein ( MBP) content of hypodense eosinophils from patients with the hypereosinophilic syndrome who had at least 90% hypodense eosinophils in their peripheral blood and compared these cells to normodense eosinophils from normal persons. Paper-5895376.
Beside the surface marker analysis of peripheral blood mononuclear cells (PBMC) we measured surface bound IgE molecules on lymphocytes and eosinophil cells, intracellular cytokines ( IL-5, INFgamma) in CD4+ lymphocytes and eosinophil major basic protein ( MBP) in eosinophils using flow cytometric detection method. Paper-9128103.
Here, we focused on the emission dynamics of various organo-metal compounds (e.g., di,- tri-, tetra-methyl tin, di-methyl mercury, tetra-methyl lead) from two different kinds of pre-treated mass waste, namely mechanically-biologically pre-treated municipal solid waste ( MBP MSW) and municipal waste incineration ash (MWIA). Paper-12436904.
Extensive extracellular MBP deposition was present in the necrotic migration tracks in the brain and around larvae in the mesenteric granulomata in association with the radiating eosinophilic deposits characteristic of the "Splendore-Hoeppli phenomenon." The Splendore-Hoeppli deposits consist in part of eosinophil granule MBP. Paper-6264900.
We have reported that the capacity of human intervertebral nucleus pulposus cell line to synthesize proteoglycan ( PG) was increased by exposure to LIPUS, and postulated that one of the mechanisms underlying this response was an increase in expression of the transforming growth factor-beta type I receptor gene (TGFbetaR1). Paper-12613260.
The soluble MBP immunoreactivities in placental homogenates and in maternal serum chromatograph identically on Sephadex G-50, and both these gestational MBP molecules migrate as though substantially larger than the MBP found in serum from patients with hypereosinophilic syndrome or purified from the eosinophil granule. Paper-4543715.
These data confirm that the eosinophil product MBP and the eosinophil chemoattractant chemokines RANTES and macrophage-inhibitory protein 1alpha are increased in upper respiratory viral infections associated with asthma exacerbations and suggest an important role for these chemokines in regulating eosinophil influx and activation. Paper-1771884.
We measured the serum levels of total MBP, using an ELISA that detects both pro- MBP and MBP, in 25 patients with leukemia (six acute myelogenous leukemia (AML), seven acute lymphoblastic leukemia (ALL), eight chronic myelogenous leukemia (CML), four chronic lymphocytic leukemia (CLL)) and five recipients of allogeneic bone marrow transplants (BMT). Paper-1164568.
These synonyms are used for gene PRG2 (proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)): Proteoglycan 2, MGC14537, MBP1, MBP, Bone marrow proteoglycan, BMPG.
These accession numbers are used for gene PRG2: Q14227 (UNIPROT__AC), P81448 (UNIPROT__AC), CAA68751 (NCBI_GENBANK__AC), AAA35965 (NCBI_GENBANK__AC).
PRG2 is a homologue of Prg2 (proteoglycan 2, bone marrow) from Mus musculus.
PRG2 is a homologue of Prg2 (proteoglycan 2, bone marrow) from Rattus norvegicus.
Important links !
iHOP - Information Hyperlinked over Proteins .
Concept & Implementation by Robert Hoffmann.