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We have localized the gene encoding human RNase k6 to within approximately 120 kb on the long (q) arm of chromosome 14 by HAPPY mapping. Paper-1668847.
At the cellular level, transcripts encoding RNase k6 were detected in normal human monocytes and neutrophils (but not in eosinophils) suggesting a role for this ribonuclease in host defense. Paper-700910.
Each gene encodes a complete ORF with no less than 86% amino acid sequence identity to human RNase k6 with the eight cysteines and catalytic histidines (H15 and H123) and lysine (K38) typically observed among members of the RNase A superfamily. Paper-1668847.
To further our understanding of the individual lineages comprising the RNase A superfamily, we have isolated and characterized 10 novel genes orthologous to that encoding human RNase k6 from Great Ape, Old World, and New World monkey genomes. Paper-1668847.
The open reading frame of RNase k6, amplified from human genomic DNA, encodes a 150 amino acid polypeptide with eight cysteines and histidine and lysine residues corresponding to those found in the active site of the prototype, ribonuclease A. The single-copy gene encoding RNase k6 maps to human chromosome 14 and orthologous sequences were detected in both primate and non-primate mammalian species. Paper-700910.
These synonyms are used for gene RNASE6 (ribonuclease, RNase A family, k6): RNS6, RNase K6, RNasek6, Ribonuclease K6.
These accession numbers are used for gene RNASE6: Q6IB39 (UNIPROT__AC), AAH20848 (NCBI_GENBANK__AC), AAC51848 (NCBI_GENBANK__AC).
RNASE6 is a homologue of RNASE6 (ribonuclease, RNase A family, k6) from Bos taurus.
RNASE6 is a homologue of RNASE6 (ribonuclease, RNase A family, k6) from Pan troglodytes.
RNASE6 is a homologue of Rnase6 (ribonuclease, RNase A family, 6) from Mus musculus.
RNASE6 is a homologue of Rnase6 (ribonuclease, RNase A family, 6) from Rattus norvegicus.
Important links !
iHOP - Information Hyperlinked over Proteins .
Concept & Implementation by Robert Hoffmann.