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The RP S19 and C5a receptor genes co-localized on the same chromosome. Paper-10936167.
The TIN-ag- RP is encoded in ten exons with introns ranging from 83 bp to 4 kb. Paper-8504940.
Expression of carbonic anhydrase-related protein CA- RP VIII in non-small cell lung cancer. Paper-9723988.
We conclude that the RP family allows valuable comparative genomics and phylogeny of Lepidoptera. Paper-10173417.
Most RP genes have common promoters and were therefore assumed to have a unified gene expression control mechanism. Paper-12002363.
After its uptake by an anuclear cell the protomitochondrium transferred several of its RP genes to the host genome. Paper-12964129.
Profiling of T-cell receptor signaling complex assembly in human CD4 T-lymphocytes using RP protein arrays. Paper-13582660.
In mammalian cells, this effect is achieved in part through a co-ordinated inhibition of RP (ribosomal protein) synthesis. Paper-10819439.
Interestingly, uterine smooth muscle cells completely lacked TIN-ag- RP expression, implying a regulated gene expression. Paper-8716153.
The RP gene knockdown system developed in this study could be a powerful tool for studying the roles of ribosomes in human diseases. Paper-12363277.
By sequencing the rpl32 gene, we have characterized the apparent complete set of the RP genes in Zea mays plastid genome. Paper-7674433.
RESULTS: The amino acid sequence of the guinea pig RP S19 deduced from the cDNA nucleotide sequence was identical to the human protein. Paper-10936167.
In particular, a highly conserved 5'-TOP (5'-terminal oligopyrimidine tract) appears to play a key role in the regulation of RP mRNA translation. Paper-10819439.
Mutations in RP genes are also associated with tissue-specific phenotypes, suggesting a possible role in organ development during early embryogenesis. Paper-12363277.
We examined cytotoxicity against tumor cells in vitro and in vivo of CTLs specific to PP- RP established from esophageal cancer patients. Paper-10923899.
A transactivation domain of MYC- RP/ GP and Delila could be located in the region between the 193rd and the 420th amino acid of MYC- RP/ GP proteins. Paper-8337251.
Duplication of the RCCX modules probably occurred before the speciation of great apes and humans as they contain the same breakpoint region of RP and Gene X gene duplication. Paper-8174972.
These data suggest that hDREF is an important transcription factor for cell proliferation which plays roles in cell cycle-dependent regulation of a number of RP genes. Paper-13129903.
Cumulative data suggest that the four tandemly arranged genes RP, complement C4, steroid 21-hydroxylase ( CYP21), and Gene X altogether form a modular structure, RCCX. Paper-8174972.
These CTLs, generated from HLA-A24-positive esophageal cancer patients, had cytotoxic activity against cancer cell lines positive for both PP- RP and HLA-A24. Paper-10923899.
Furthermore, adoptive transfer of the PP- RP-specific CTL line inhibited the growth of a human esophageal cancer cell line engrafted in nude mice. Paper-10923899.
The cDNA produced by RP or virus specific primers (SP) was used to detect PLRV and PVY from infected tubers in a duplex reverse transcription polymerase chain reaction (d-RT-PCR). Paper-8690390.
RESULTS: In 26 esophageal cancer tissues, an average of relative ratio of the expression of the PP- RP mRNA in cancer cells versus adjacent normal esophageal tissues was 396. Paper-10923899.
The results revealed that (1) most RP genes are coordinately expressed at the mRNA level, with higher signals in the spleen, lymph node dissection (LND), and fetal brain. Paper-12002363.
Backcross breeding enables breeders to transfer a desired trait such as a transgene from one variety (donor parent, DP) into the favored genetic background of another (recurrent parent, RP). Paper-13724059.
Using a polyclonal anti- TIN-ag- RP antibody, TIN-ag- RP expression was predominantly seen in vascular smooth muscle (VSM) cells, but also in cardiac and skeletal muscle cells as well as in kidney. Paper-8716153.
Several examples of the introduction of a gene from one gene complex into another (introgression) are found when chloroplast RP gene clusters are compared to those in Escherichia coli or cyanobacteria. Paper-7858657.
2. Immunohistochemical analysis revealed that, in 20 of the 22 esophageal cancer tissues, PP- RP protein was strongly expressed only in the cancer cells and not so in normal esophageal epithelial cells. Paper-10923899.
Based on the high degree of homology of the amino acid sequences and genomic organization between TIN-ag- RP and TIN-ag, we suggest that both molecules may form a distinct group or family of TIN-ag-like proteins. Paper-8504940.
Determination of the DNA sequences for RP2 from two different HLA haplotypes revealed identical hybrid sequences which resulted from fusion of RP with the tenascin-like Gene X and truncation of the 5' regions of both genes. Paper-8174972.
Furthermore, human TIN-ag- RP tagged with the T7-epitope, was expressed in HeLa cells, and was found to be localized in vesicular compartments as well as secreted into the medium suggesting the involvement of the endosomal trafficking pathway. Paper-8504940.
Therefore, PP- RP may prove to be an ideal tumor antigen useful for diagnosis and immunotherapy for patients with esophageal cancer. cDNA microarray analysis is a useful method to identify ideal tumor-associated antigens. Paper-10923899.
The amino acid sequence of TIN-ag- RP is composed of a 21 aa long signal sequence, a 181 aa long N-terminal domain containing two epidermal growth factor-like domains, a follistatin motif, and a 265 aa long cathepsin B-like domain. Paper-8716153.
Localization studies in HeLa cells stably transfected with TIN-ag- RP cDNA showed that TIN-ag- RP is glycosylated and actively secreted, a finding in line with its proposed function as a structural or regulatory protein similar to TIN-ag. Paper-8716153.
Comparison of RP genes from humans, Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae revealed the coding sequences to be highly conserved (63% homology on average), although gene size and the number of exons vary. Paper-9393057.
Northern blot analysis revealed a single TIN-ag- RP transcript of 2.4 kb in various tissues with the highest transcript levels detected in aorta, heart, placenta, skeletal muscle, kidney, and a colorectal adenocarcinoma cell line. Paper-8716153.
The amino acid sequence of the predicted protein of 467 aa was 46% identical with that of human tubulointerstitial nephritis antigen ( TIN-ag), and therefore, the protein was tentatively designated as the TIN-ag-related protein ( TIN-ag- RP). Paper-8716153.
The positions of the introns are also conserved among these species as follows: 44% of human introns are present at the same position in either D. melanogaster or C. elegans, suggesting RP genes are highly suitable for studying the evolution of introns. Paper-9393057.
In addition, transient luciferase assays revealed that hDRE-like sequences act as positive elements for RP gene transcription and cotransfection of an hDREF- expressing plasmid was found to stimulate RP gene promoter activity. Paper-13129903.
Like that of hDREF, expression of RP genes is increased during the late G(1) to S phases, and depletion of hDREF using short hairpin RNA- mediated knockdown decreased RP gene expression and cell proliferation in normal human fibroblasts. Paper-13129903.
CONCLUSIONS: The expression of PP- RP in esophageal cancer cells was significantly higher than in normal cells, and the CTLs recognizing PP- RP killed tumor cells in vitro and also showed tumor rejection effects in a xenograft model. Paper-10923899.
Among the 7 RP genes whose knockdown produced severe brain phenotypes, 3 human orthologs are located within chromosomal regions that have been linked to brain-associated diseases, suggesting a possible involvement of RP genes in brain or neurological diseases. Paper-12363277.
Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region. Molecular cloning, exon-intron structure, composite retroposon, and breakpoint of gene duplication. Paper-8174972.
These accession numbers are used for gene RP: .
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