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The epithelial cells of some thymomas also express Syn. Paper-1641019.
Syn density was almost identical across the three genotypes. Paper-2099412.
Synaptophysin immunohistochemistry in the human cochlea. Paper-10194815.
Synaptophysin expression in the striatum in Huntington's disease. Paper-6530190.
Synaptophysin in the cochlear nucleus following acoustic trauma. Paper-9577637.
The first report of the Systolic and Pulse Pressure ( SYPP) Working Group. Paper-2135916.
Synaptophysin. A new marker for pancreatic neuroendocrine tumors. Paper-5483192.
For this purpose, antibodies to substance P and to synaptophysin were used. Paper-6656793.
Synaptophysin and NF were present in the large rosettes of pineocytomas. Paper-8180990.
Melatonin also inhibits the secretion of synaptophysin in PC12 cells. Paper-1860639.
The cDNA and derived amino acid sequences for rat and human synaptophysin. Paper-5454051.
All four carcinoid tumors were immunoreactive with chromogranin and synaptophysin. Paper-9411744.
About 30% of the stromal cells showed a weak cytoplasmic synaptophysin positivity. Paper-6190617.
The development of synaptophysin immunoreactivity in the human sympathetic ganglia. Paper-9040987.
Additionally, synaptophysin may be a specific marker for some central neurocytomas. Paper-7103290.
Use of synaptophysin immunohistochemistry in intestinal motility disorders. Paper-11075577.
On immunochemistry, the tumor stained positive for chromogranin A and synaptophysin. Paper-12258279.
Sorting of synaptophysin into special vesicles in nonneuroendocrine epithelial cells. Paper-8155990.
Synaptophysin has a selective distribution in early endosomes of PC12 cells. Paper-7675961.
Synaptophysin staining in normal brain: importance for diagnosis of ganglioglioma. Paper-1418512.
Synaptophysin regulates clathrin-independent endocytosis of synaptic vesicles. Paper-8457618.
Three common amino acid motifs ( SYP, TYVS and VRH) were found among these eight sequences. Paper-952285.
Tyrosine phosphorylation of synaptophysin in synaptic vesicle recycling. Paper-11182566.
Most pituitary adenomas, including null cell adenomas, immunostained with SYP. Paper-5829280.
In addition, antibodies to Syn stained nerve structures surrounding the thymic blood vessels. Paper-1641019.
Synaptophysin reactivity was present in 10 phaeochromocytomas and in the 8 paragangliomas. Paper-7655160.
Immunocytochemical studies on synaptophysin in the anterior horn of lower motor neuron disease. Paper-7936281.
Synaptophysin was labeled using silver-intensified immunogold in dissociated muscle fibers. Paper-679263.
Synaptophysin immunoreactivities were also similar in Parkinson's disease and control cases. Paper-8514128.
All tumors were negative for leukocyte common antigen, muscle-specific actin, and synaptophysin. Paper-47512.
A second population of low-density vesicles contains synaptophysin but not hGH or norepinephrine. Paper-6743920.
Immunocytochemical localization of synaptophysin in human hypophyses and pituitary adenomas. Paper-5829280.
Expression of a kinase anchoring protein 79 and synaptophysin in the developing human red nucleus. Paper-9256850.
The results show that expression of synaptophysin can be maintained during formation of metastases. Paper-5453289.
AIMS: To investigate synaptophysin gene expression in the cerebral cortex in schizophrenia. Paper-2186885.
Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles. Paper-2116869.
Immunohistochemical study on synaptophysin in the spinal cord of chronic anterior poliomyelitis. Paper-287676.
Hippocampal synaptophysin immunoreactivity is reduced during natural hypothermia in ground squirrels. Paper-9734581.
Synaptic vesicle proteins, synaptophysin and chromogranin A in amyotrophic lateral sclerosis. Paper-386314.
Synaptophysin is a protein involved in neurotransmitter exocytosis and is a neuroendocrine marker. Paper-2044932.
Synaptophysin protein and mRNA expression in the human hippocampal formation from birth to old age. Paper-12197335.
Usefulness of synaptophysin immunohistochemistry in an adult case of choroid plexus carcinoma. Paper-8596578.
The neuroendocrine cells within the bronchial-type epithelium stained for calcitonin and synaptophysin. Paper-12362316.
In this study, we show that overexpression of synaptophysin enhances the mu-opioid receptor endocytosis. Paper-12381869.
Synaptophysin: structure of the human gene and assignment to the X chromosome in man and mouse. Paper-16514.
Synaptophysin in choroid plexus epithelial cells: no useful aid in differential diagnosis. Paper-2016944.
The expression of intermediate filaments and synaptophysin in Y79 retinoblastoma cells was studied. Paper-5830457.
Synaptophysin and chromogranin A immunoreactivities of Lewy bodies in Parkinson's disease brains. Paper-8174911.
Two melanomas contained neurofilament-positive tumor cells, which were however negative for synaptophysin. Paper-6498831.
Synaptophysin immunoreactivity was determined in the left cingulate gyrus from the same patient groups. Paper-1465330.
Aberrant neurofilament protein and synaptophysin expression in malignant melanoma of the nasal cavity. Paper-10458768.
Co-localization of synaptophysin with different neuroendocrine hormones in the human gastrointestinal tract. Paper-1778212.
In the ciliary ganglion, upregulation of synaptophysin II mRNA correlates very well with synaptogenesis. Paper-7660618.
The LCNEC showed organoid and trabecular growth patterns and was positive for chromogranin and synaptophysin. Paper-1976232.
Decreased synaptophysin in the medial temporal lobe in schizophrenia demonstrated using immunoautoradiography. Paper-467188.
Prognostic significance of synaptophysin in stage I of squamous carcinoma and adenocarcinoma of the lung. Paper-12519735.
Synaptophysin is an integral membrane protein of small synaptic vesicles in brain and endocrine cells. Paper-16514.
Synaptophysin expression in the human spinal cord. Diagnostic implications of an immunohistochemical study. Paper-790573.
Synaptophysin: a sensitive and specific marker for ganglion cells in central nervous system neoplasms. Paper-6535869.
Synaptophysin: a sensitive and specific marker for ganglion cells in central nervous system neoplasms. Paper-6536975.
Neuronotypic differentiation results in reduced levels and altered distribution of synaptophysin in PC12 cells. Paper-7639793.
PPNAD nodules and the PPNAD cell line, but not the extranodular adrenal cortex, stained intensely for SYN. Paper-1785224.
Seven days after treatment there was a significant loss of hair cells and synaptophysin-stained area (SSA). Paper-9868977.
The localization of synaptophysin in the organ of Corti of the human as shown by immunoelectron microscopy. Paper-7847030.
Both types of lesion resulted in synaptophysin upregulation in contralateral and ipsilateral cortical areas. Paper-12432796.
Synaptophysin in the human retina and retinoblastoma. An immunohistochemical and Western blotting study. Paper-6441766.
Synaptophysin may act as an important calcium binding protein in the sensory transduction of hair cells. Paper-6159037.
Determination of the base sequence of h-Sp-1 showed a size of 2170 bp and 43.4% homology with human synaptophysin. Paper-9926857.
Synaptophysin was significantly lower in presenile than senile AD in right frontal and bilateral parietal lobes. Paper-9484345.
Thus, rhabdomyosarcomas (0/5), lymphomas (0/4), or Ewing's sarcomas (0/2) were negative for synaptophysin. Paper-5785838.
Ultrastructural distribution of synaptophysin and synaptic vesicle recycling at the frog neuromuscular junction. Paper-679263.
Synaptophysin immunohistochemistry during vestibular hair cell recovery after gentamicin treatment. Paper-9868977.
Glial cells were highlightened by antibodies to GFAP and neuronal cells by chromogranin and synaptophysin markers. Paper-12981951.
We determined synaptophysin concentration from motor cortex in only 4 of our PSP cases, 2 demented and 2 non-demented. Paper-8969413.
In normal liver and chronic hepatitis synaptophysin immunoreactivity was detected in the lobules and portal areas. Paper-8198380.
Synaptophysin gene expression in schizophrenia. Investigation of synaptic pathology in the cerebral cortex. Paper-2186885.
Changed intestinal distributions of SY-positive synaptic vesicles usually accompany colonic ganglion cell disorders. Paper-11075577.
Cholinergic fibers were depleted to 15% of control values, while synaptophysin density was not significantly altered. Paper-7498577.
Calcineurin and synaptophysin in the human spinal cord of normal individuals and patients with familial dysautonomia. Paper-6817412.
Quantitative study of synaptophysin immunoreactivity of cerebral cortex and spinal cord in motor neuron disease. Paper-341364.
Alpha and beta nicotinic acetylcholine receptors subunits and synaptophysin in putamen from Parkinson's disease. Paper-8514128.
Severe panencephalic Pick's disease with Alzheimer's disease-like neuropil threads and synaptophysin immunoreactivity. Paper-7912359.
We have studied the endocytic pathway in PC12 cells and localized synaptophysin to a subpopulation of early endosomes. Paper-7675961.
These findings suggest that the major function of SNAT1 is not to replenish the transmitter pools of Glu and GABA. Paper-10287748.
Synaptophysin immunohistochemistry reveals inside-out pattern of early synaptogenesis in ferret cerebral cortex. Paper-7695216.
Synaptophysin identified in metastases of neuroendocrine tumors by immunocytochemistry and immunoblotting. Paper-5453289.
Immunocytochemical labeling of undifferentiated PC12 cells reveals concentrations of synaptophysin in the perinuclear region. Paper-7639793.
Dietary curcumin (2000 ppm), but not ibuprofen, suppressed oxidative damage (isoprostane levels) and synaptophysin loss. Paper-8918827.
The origin of the Merkel cells (MC) being far from clear, this study was performed to establish if normal MC express SY. Paper-5830144.
In temporal cortex (Brodmann area 21), synaptophysin mRNA was decreased in AD and non-AD dementia groups compared to controls. Paper-1414508.
A clinicopathologic and immunohistochemical analysis of 53 cases of medulloblastoma with emphasis on synaptophysin expression. Paper-6537959.
SYN expression was studied with a monoclonal antibody (MAb) by the immunoperoxidase technique in 53 medulloblastomas. Paper-6537959.
There it plays a role in the process of membrane fusion during exocytosis by interacting with syntaxin and synaptophysin. Paper-11479760.
In the gastrointestinal tract (except the antrum), chromogranin A is a better general neuroendocrine marker than synaptophysin. Paper-1778212.
No reduction of EAATs or synaptophysin immunostaining was observed in demyelinated cortex in the absence of activated microglia. Paper-12500859.
The synaptophysin immunoreactivity revealed connections between the terminals and the neurons of the deep cerebellar nuclei. Paper-1576582.
We identify synaptophysin as a major specifically cholesterol-binding protein in PC12 cells and brain synaptic vesicles. Paper-2116869.
One hundred ninety-four cases of EBD carcinomas were analyzed using immunohistochemistry with synaptophysin and chromogranin. Paper-11035394.
Interestingly, synaptophysin was downregulated in these MRT cell lines in contrast with the neuroblastoma cell lines. Paper-9308658.
Cholinergic fiber loss occurs in the absence of synaptophysin depletion in Alzheimer's disease primary visual cortex. Paper-7498577.
This prenatal insult caused age-specific changes in accumbal dopamine levels and in synaptophysin expression in the frontal cortex. Paper-13071496.
Overexpression of synaptophysin in MN9D cells can significantly increase the resistance of the transformants to MPP+ toxicity. Paper-10739107.
Synaptophysin mRNA signal correlated negatively with the degree of dementia and negatively with the pathological severity of AD. Paper-1414508.
Temporal cortex synaptophysin mRNA is reduced in Alzheimer's disease and is negatively correlated with the severity of dementia. Paper-1414508.
Synaptophysin was found to be sulfated, which facilitated the determination of its exit route from the trans-Golgi network (TGN). Paper-6994861.
Detection of synaptophysin-producing cells in human thymus by immunohistochemistry and nonradioactive in situ hybridization. Paper-1718188.
Additionally, fifteen of sixteen neoplasms (93.8%) with MTSCC showed the expression of either chromogranin A or synaptophysin or both. Paper-11377794.
These cytoplasmic structures were immunoreactive with antibodies against chromogranin A and synaptophysin in paraffin-embedded tissue. Paper-9358296.
Synaptophysin immunoreactivity in Pick's disease: comparison with Alzheimer's disease and dementia with Lewy bodies. Paper-11617568.
We conclude that SYN is a useful marker for medulloblastomas, indicating that this tumor is a primitive neuronal-neuroblastic neoplasm. Paper-6537959.
The midbrain tumors showed weak reactivity to synaptophysin, and they blended with reactive astrocytes positive for glial markers. Paper-6927372.
Further, SYN mRNA expression was studied by nonradioactive in situ hybridization using digoxigenin-labeled oligonucleotide probes. Paper-207776.
Our data highlight synaptophysin as a sensitive and specific marker of both neuronal lineage and neoplastic character in gangliogliomas. Paper-6535869.
Synaptophysin staining suggested that these peripheral nerve fibers in the inflammatory areas still contained synaptic vesicles. Paper-8246392.
Reduction of synaptophysin immunoreactivity in the prefrontal cortex of subjects with schizophrenia. Regional and diagnostic specificity. Paper-1195314.
In AD as compared to controls, a decrease in synaptophysin immunostaining was evident in the terminal zone of the perforant pathway. Paper-7493477.
We present immunohistochemical data showing synaptophysin expression by cochlear hair cells in both late stage embryos and adult chickens. Paper-849087.
Transplanted OB precursors gave rise to interneurons with dendritic spines in close proximity to synaptophysin-positive boutons. Paper-12268940.
The interrelationships of synaptophysin, other presynaptic proteins, the cholinergic system, and severity of dementia in AD remain unclear. Paper-9075523.
Synaptophysin expressed in the bronchopulmonary tract: neuroendocrine cells, neuroepithelial bodies, and neuroendocrine neoplasms. Paper-5622848.
Dendritic spines and immunoreactivity of synaptophysin in the frontal cortex of humans with infantile brain damage. A correlative study. Paper-7963843.
We investigated human thymic tissue by immunohistochemistry and in situ hybridization for the presence of synaptophysin-producing cells. Paper-1718188.
The double labeling immunohistochemistry revealed that this granular structure overlaps synaptophysin-positive dystrophic neurites. Paper-10658919.
Pan-endocrine markers chromogranin A and synaptophysin were positive in almost all carcinoid tumors, in 4 and 7 of the 10 NECs, respectively. Paper-10781039.
Pheochromocytoma was diffusely positive for synaptophysin and chromogranin, whereas staining was focal and punctate in neuroblastoma. Paper-8017180.
An immunohistological study with an antibody to synaptophysin showed that the number of synapses in transplanted ganglia was severely reduced. Paper-1682280.
Immunohistochemical neuronal markers (neurofilament protein, synaptophysin and chromogranin) confirm the presence of a neuronal cell component. Paper-11528914.
The latter structures displayed synaptophysin immunoreactivity, mostly localized to outer membranes of synaptic vesicles and dense bodies. Paper-7191853.
As a marker for the synaptic vesicle-like organelles in this system, we have used the integral membrane glycoprotein p38 or synaptophysin. Paper-6610580.
Newly synthesized synaptophysin is transported to synaptic-like microvesicles via constitutive secretory vesicles and the plasma membrane. Paper-6994861.
The aim was to determine if dementia in Lewy body disease was associated with diminished concentrations of midfrontal cortex synaptophysin. Paper-1421314.
However, in reactive retinas present in retinoblastoma eyes, synaptophysin was often observed in perikarya and processes of photoreceptors. Paper-6441766.
In rats, entorhinal lesions resulted in diminished immunoreactivity for both synaptophysin and NT75 in the perforant pathway terminal zone. Paper-7493477.
In parahippocampal gyrus, the loss of synaptophysin messenger RNA per neuron in schizophrenia was greater in deep than superficial laminae. Paper-400221.
The predicted protein product derived from this clone is truncated, and the tissue distribution of HL-5 is different from that of synaptophysin. Paper-7236524.
In CJD patients with a long clinical course, synaptophysin immunoreactivity decreased, and synaptic PrPCJD accumulated with a wider distribution. Paper-7213729.
Positive SY immunostaining was solely restricted to the neural and sensory structures and did not include supporting cells of the organ of Corti. Paper-10194815.
The synaptic-vesicle-specific proteins rab3a and synaptophysin are reduced in thalamus and related cortical brain regions in schizophrenic brains. Paper-2028121.
Polariscopy, trichrome staining, and immunostaining for synaptophysin were very useful for differentiating spinal cord from peripheral nerve. Paper-8424457.
MSCs treated with retinoic acid resulted in synaptic transmission, based on immunostaining of synaptophysin and electrophysiological studies. Paper-11284357.
A transient increase in synaptophysin mRNA was observed after treatment with venlafaxine and fluoxetine whereas imipramine had no effect. Paper-12675206.
Synaptophysin was expressed in all central neurocytomas and DNTs, in three oligodendrogliomas (43%), and in three oligoastrocytomas (75%). Paper-9266562.
The superficial cellular layer was also diffusely stained for synaptophysin; there was a positive reaction in the linearly arranged myelin sheaths. Paper-6681968.
In most cases, the studied oncocytomas did not react to synaptophysin showing different results from other adenomas of the anterior hypophysis. Paper-6079816.
Quantitative analysis of synaptophysin immunoreactivity in human neocortex after cardiac arrest: confocal laser scanning microscopy study. Paper-1807907.
Smooth muscle actin reactivity was more common in the benign tumors (p = 0.046) and synaptophysin reactivity in the malignant tumors (p = 0.010). Paper-8797010.
Histologically, prominent neurocytic rosettes with synaptophysin expression were embedded in a glial tumor component resembling pilocytic astrocytoma. Paper-10047285.
PGA/ chitosan grafts were evaluated as (+++) and (++), while PGA grafts were evaluated as (++) and (+) with use of synaptophysin antibody. Paper-13044091.
Quantitative assessment of the synaptophysin immuno-reactivity of the cortical neuropil in various neurodegenerative disorders with dementia. Paper-7831472.
Compared with synaptophysin, NB84 was more sensitive, although less specific, in the identification of neuroblastoma in formaldehyde-fixed tissue. Paper-1346475.
Comparative immunohistochemical study on synaptophysin expression in the anterior horn of post-poliomyelitis and sporadic amyotrophic lateral sclerosis. Paper-898871.
Some immunoreactivity for synaptophysin was also found in the secretory granules of the insulin-producing cells, although it was weaker in this location. Paper-6892470.
Immunostaining of SYN in the cerebral cortex (an area not exhibiting spongiform lesions) was similar in viral infected and age-matched control mice. Paper-109659.
Some adenohypophysial corticotrophs, most corticotrophs spreading to the posterior lobe, and Crooke's hyaline material did not immunoreact with anti- SYP. Paper-5829280.
In contrast, synaptophysin was expressed in both the neonate and adult cochlea; immunoreactivity was found below IHCs around P4 and below OHCs at P5. Paper-831840.
We have determined the structure and organization of the human synaptophysin gene and have established the chromosome localizations in man and mouse. Paper-16514.
Synaptophysin immunoreactivity can be quantified by image analysis to evaluate loss of presynaptic terminals in human neurodegenerative diseases. Paper-341364.
Central neurocytoma is a rare brain tumor composed of small round synaptophysin-positive cells, suggesting a neuronal origin of these tumor cells. Paper-641768.
Synaptophysin, an integral membrane glycoprotein of presynaptic vesicles, was tested as an immuno-histochemical marker for childhood neuroblastoma. Paper-5785838.
Morphometry of synaptophysin immunoreactive ganglion cells in Auerbach plexus in patients with colorectal cancer. Is this a new prognostic factor? Paper-10898271.
Increased SYP immunoreactivity was accompanied with degeneration of neuronal cell bodies, their processes and terminals as well as glial cell proliferations. Paper-11307436.
Localization of the glutamine transporter SNAT1 in rat cerebral cortex and neighboring structures, with a note on its localization in human cortex. Paper-10287748.
Synaptophysin and syntaxin-1 are membrane proteins that associate with synaptic vesicles and presynaptic active zones at nerve endings, respectively. Paper-8997929.
The membrane of these presumptive secretory microvesicles is known to contain synaptophysin, a major integral glycoprotein of neuronal synaptic vesicles. Paper-7809543.
Axon varicosities positive for synaptophysin were present in the adventitia of ICA of young animals but were absent in the ligamentous cord of mature animals. Paper-12326758.
Synaptophysin is an integral membrane protein of synaptic vesicles characterized by four transmembrane domains with both termini facing the cytoplasm. Paper-9185147.
Immunohistochemical markers such as chromogranin A, synaptophysin, and serotonin have proven to be useful diagnostic tools in evaluating carcinoid tumors. Paper-6537945.
Synaptophysin and/or chromogranin A may be expressed in epithelial cells of normal and dysplastic mammary gland and in some cancer of the breast. Paper-1010914.
Immunoelectron microscopy showed synaptophysin expression in the extraskeletal myxoid chondrosarcoma but not in the skeletal chondrosarcoma case. Paper-9107659.
Topology of innervation of labial salivary glands by protein gene product 9.5 and synaptophysin immunoreactive nerves in patients with Sjögren's syndrome. Paper-7505417.
These processes are immunopositive for synaptophysin, and they terminate in two strata occupied by the dendrites of amacrine cells and ganglion cells. Paper-8300321.
At the ultrastructural level, synaptophysin labeling is found on similar organelles in both undifferentiated and nerve growth factor-stimulated PC12 cells. Paper-7639793.
One of the most prominent features of synaptophysin is that its cytoplasmic C-terminus largely consists of pentapeptide repeats initiated by a tyrosine residue. Paper-11182566.
However, in some carcinoma cases ChgA and Syn were revealed in carcinoma cells, in myoepithelial cells, in some stromal mesenchymal cells and endothelial cells. Paper-1006686.
Application of high pharmacological doses of estradiol promoted only synaptophysin expression, a presynaptic protein, but did not increase the number of boutons. Paper-11838690.
Reduction of the small synaptic vesicle protein synaptophysin but not the large dense core chromogranins in the left thalamus of subjects with schizophrenia. Paper-2085113.
The other is the essential role of membrane cholesterol, which specifically interacts with synaptophysin, the major transmembrane protein of synaptic vesicles. Paper-8550313.
RESULTS: Prenatal exposure to ethanol did not alter levels of presynaptic proteins in the hippocampus or levels of synaptophysin in the prefrontal cortex. Paper-11511633.
At day 60, immunohistochemistry revealed a 13.5% +/- 5.3% reduction in synaptophysin in the infralimbic cortex and cingulate gyrus in isolation-housed subjects. Paper-12682406.
Two isoforms of the neural cell adhesion molecules were increased in the hippocampus of BD, whereas the synaptic protein marker, synaptophysin, was not changed. Paper-8511231.
The dense ligamentous tissue proper was practically aneural, as was seen in staining for the generalized neuronal markers protein gene product 9.5 and synaptophysin. Paper-7373548.
BACKGROUND: Decreased expression of proteins such as synaptophysin in the hippocampus and prefrontal cortex in schizophrenia is suggestive of synaptic pathology. Paper-2186885.
Synaptophysin is an integral membrane glycoprotein (Mr 38,000) that occurs in presynaptic vesicles of neurons and in similar vesicles of the adrenal medulla. Paper-5246506.
Synaptophysin (ICN, Costa Mesa, California) reactivity was strong in testicular tumor of the adrenogenital syndrome but rarely observed in Leydig cell tumor. Paper-12424689.
By immunohistochemical staining for chromogranin A and synaptophysin, NE cell differentiation was detected in eight of 48 patients (16.7%) with PD adenocarcinoma. Paper-12138335.
A series of nonneuroendocrine tumors, such as adenocarcinomas, sarcomas, lymphomas, and melanomas, were negative for both synaptophysin and NF proteins. Paper-5565102.
Synaptophysin immunohistochemistry is an indirect labeling method with a high detection rate for intestinal ganglion cells by demonstrating their synapses. Paper-11075577.
Quantitative immunohistochemistry of synaptophysin in human neocortex: an alternative method to estimate density of presynaptic terminals in paraffin sections. Paper-6815222.
Dystrophic neurites were not detected by a modified Bielschowsky stain or by neurofilament, synaptophysin and tau immunohistochemistry in the olfactory mucosa. Paper-946995.
We identified palpable tumor masses (log-rank test, P = 0.0027) and synaptophysin expression (log-rank test, P = 0.0422) as prognostic unfavorable markers for renal PNET. Paper-12082855.
In the search for proteins regulating mu-opioid receptor (MOPr) endocytosis, synaptophysin was found to bind to the rat mu-opioid receptor in yeast two-hybrid assay. Paper-12381869.
Immunohistochemical studies revealed variable immunoreactivity for simple epithelial cell cytokeratins and for synaptophysin (weak staining) in a minority of tumor cells. Paper-6874223.
It was evenly distributed throughout the compartment at 14-22 weeks of gestation, and then from 23 weeks to the time of birth, there was a pericellular arrangement of SYN. Paper-9256850.
Synaptophysin immuno-reactivity was found in all neuroblastomas (6/6), but not in the other small round-cell tumors to be considered in its differential diagnosis. Paper-5785838.
Loss of synaptophysin-positive boutons on lumbar motor neurons innervating the medial gastrocnemius muscle of the SOD1G93A G1H transgenic mouse model of ALS. Paper-11291904.
The other 21 cases of gangliogliomas were originally diagnosed as astrocytoma or mixed glioma, but were shown by synaptophysin staining to be gangliogliomas. Paper-7633103.
Core biopsy of the mass and left axillary lymph node aspiration revealed neuroendocrine tumor of the breast, which stained positive for synaptophysin and chromogranin. Paper-12621731.
As soon as cell migration had finished, the entire cortical plate contained dense synaptophysin immunoreactivity, in a pattern similar to that observed in the adult animal. Paper-7695216.
The expression of synaptophysin in epithelial cells of the thymic cortex suggests that this protein may be involved in secretory activities related to T-cell maturation. Paper-1718188.
Synaptophysin, a membrane glycoprotein of presynaptic vesicles, and neurofilament (NF) proteins were tested as immunohistochemical markers for neuroendocrine tumors. Paper-5565102.
Vascular dementia in Spatz-Lindenberg's disease (SLD): cortical synaptophysin immunoreactivity as compared with dementia of Alzheimer type and non-demented controls. Paper-7873073.
Loss of neurons would be expected to lead to the retrograde degeneration of their afferents, which should be reflected in a loss of presynaptic markers such as synaptophysin. Paper-10646095.
In addition, no age-related change in number of synaptophysin-positive boutons was observed in the molecular layer of the dentate gyrus or CA1 region of hippocampus. Paper-1822300.
Poorly differentiated endocrine carcinomas lack large dense core vesicles markers (chromogranin A), while widely express synaptophysin and cytosol endocrine markers. Paper-10238221.
All other patients with small cell neuroendocrine carcinomas of the bladder and prostate demonstrated extremely high proliferation activity (>80%) and expressed Chr A and SNP. Paper-9553132.
Pineal parenchymal tumor (PPT) differentiation was confirmed by immunohistochemical detection of neuroendocrine markers ( synaptophysin, neurofilaments, and chromogranin A). Paper-9666399.
To assess the synaptic changes in the motor neurons, we examined immunoreactivities for synaptophysin in the spinal cord of 11 patients with Werdnig-Hoffmann disease. Paper-845343.
For example, the reduction in synaptophysin messenger RNA in subicular neurons may be accompanied by decreased density of synaptic terminals in the nucleus accumbens. Paper-400221.
Neuroendocrine differentiation of sparse cells interspersed in the pluristratified epithelium was documented by immunohistochemical staining for chromogranin and synaptophysin. Paper-9035346.
This review will cover the evidence for tyrosine phosphorylation of synaptophysin and how this phosphorylation may control its function in the SV life cycle. Paper-11182566.
Differentiation markers as an aid in the histological diagnosis of small-cell carcinoma of the lung: synopsis of intermediate filament protein and synaptophysin expression. Paper-5871757.
This pattern resulted from binding of the antibodies to synaptic complexes of both rods and cones, shown by double-labelling with antibodies to either synaptophysin or actin. Paper-118728.
This revealed the presence of 29 putative exons, organized into three genes, in addition to the 7 exons of the complete SYP coding region, all mapping within a 44-kb interval. Paper-1301901.
The results show that fibrous SYN immunolabelling most probably indicating intra-axonal transport of synaptic vesicles can only be observed during the first half of gestation. Paper-2098786.
Synaptophysin immunoreactivity of the cortical neuropil in vascular dementia of Binswanger type compared with the dementia of Alzheimer type and nondemented controls. Paper-8202230.
Preliminary analysis of the latter suggested that this might reflect a high density of coding sequences and we therefore undertook the complete sequencing of a SYP-containing cosmid. Paper-1301901.
Here, we tested whether intra-carotid infusion of bone marrow stromal cells promotes synaptophysin expression and neurological functional recovery after stroke in rats. Paper-12151988.
The biogenesis of synaptic-like microvesicles (SLMVs) in neuroendocrine cells was investigated by studying the traffic of newly synthesized synaptophysin to SLMVs in PC12 cells. Paper-6994861.
We conclude that the neuroendocrine marker SYN is expressed in a small subset of non-small-cell carcinomas of the cervix and its expression seems to correlate with a poor outcome. Paper-9320176.
BACKGROUND: The prognostic significance of the presence of a neuroendocrine marker ( synaptophysin, SY) was analyzed in stage I of squamous carcinoma and adenocarcinoma of the lung. Paper-12519735.
To understand the role of the synapsins and synaptophysin in the biology of a nerve cell means to elucidate the fundamental mechanism of brain function, the release of neurotransmitter. Paper-7591783.
The innervation of human cerebral blood vessels has been examined using synaptophysin, a marker of synaptic vesicles, and chromogranin A, a marker of large dense-core vesicles. Paper-304151.
Additionally, the distribution of the SV protein synaptophysin, when expressed by transfection in fibroblastic cells or in polarized epithelial cells (MDCK cells), was investigated. Paper-7816566.
SNAT1 mediates glutamine (Gln) influx into neurons and is believed to replenish the transmitters pools of glutamate ( Glu) and gamma-aminobutyric acid ( GABA). Paper-10287748.
Synaptophysin was consistently present in the tumor cells of pheochromocytomas (10/10), thyroid medullary carcinomas (8/8), and pancreatic islet cell tumors (6/6). Paper-5565102.
Immunochemistry confirmed