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Synaptophysin in human breast carcinomas. Paper-6890165.
The epithelial cells of some thymomas also express Syn. Paper-1641019.
We found that all 22 PNETs expressed synaptophysin extensively. Paper-6829145.
Syn density was almost identical across the three genotypes. Paper-2099412.
Synaptophysin expression in the striatum in Huntington's disease. Paper-6530190.
Synaptophysin in the cochlear nucleus following acoustic trauma. Paper-9577637.
The first report of the Systolic and Pulse Pressure ( SYPP) Working Group. Paper-2135916.
Synaptophysin. A new marker for pancreatic neuroendocrine tumors. Paper-5483192.
For this purpose, antibodies to substance P and to synaptophysin were used. Paper-6656793.
Synaptophysin and NF were present in the large rosettes of pineocytomas. Paper-8180990.
Melatonin also inhibits the secretion of synaptophysin in PC12 cells. Paper-1860639.
Microves synaptophysin (neurons) and neuron-glial antigen 2 (NG2) ( pericytes). Paper-13512333.
The cDNA and derived amino acid sequences for rat and human synaptophysin. Paper-5454051.
Normal Purkinje cells did not express pNFP, synaptophysin or alphaB-crystallin. Paper-1578993.
All four carcinoid tumors were immunoreactive with chromogranin and synaptophysin. Paper-9411744.
About 30% of the stromal cells showed a weak cytoplasmic synaptophysin positivity. Paper-6190617.
The development of synaptophysin immunoreactivity in the human sympathetic ganglia. Paper-9040987.
Additionally, synaptophysin may be a specific marker for some central neurocytomas. Paper-7103290.
Use of synaptophysin immunohistochemistry in intestinal motility disorders. Paper-11075577.
Synaptophysin stains 100% of carcinoid tumors regardless of their site of origin. Paper-1560972.
Sorting of synaptophysin into special vesicles in nonneuroendocrine epithelial cells. Paper-8155990.
Synaptophysin has a selective distribution in early endosomes of PC12 cells. Paper-7675961.
Synaptophysin staining in normal brain: importance for diagnosis of ganglioglioma. Paper-1418512.
Aberrant diffuse expression of synaptophysin in a sinonasal alveolar rhabdomyosarcoma. Paper-13198508.
Synaptophysin regulates clathrin-independent endocytosis of synaptic vesicles. Paper-8457618.
Three common amino acid motifs ( SYP, TYVS and VRH) were found among these eight sequences. Paper-952285.
Most pituitary adenomas, including null cell adenomas, immunostained with SYP. Paper-5829280.
In addition, antibodies to Syn stained nerve structures surrounding the thymic blood vessels. Paper-1641019.
Synaptophysin reactivity was reduced around the soma of degenerating normal motor neurons. Paper-13319413.
Synaptophysin reactivity was present in 10 phaeochromocytomas and in the 8 paragangliomas. Paper-7655160.
Immunocytochemical studies on synaptophysin in the anterior horn of lower motor neuron disease. Paper-7936281.
Synaptophysin immunoreactivities were also similar in Parkinson's disease and control cases. Paper-8514128.
All tumors were negative for leukocyte common antigen, muscle-specific actin, and synaptophysin. Paper-47512.
Enhanced degradation of synaptophysin by the proteasome in mucopolysaccharidosis type IIIB. Paper-13736789.
A second population of low-density vesicles contains synaptophysin but not hGH or norepinephrine. Paper-6743920.
Immunocytochemical localization of synaptophysin in human hypophyses and pituitary adenomas. Paper-5829280.
Expression of a kinase anchoring protein 79 and synaptophysin in the developing human red nucleus. Paper-9256850.
SNAT1 immunoreactivity (ir) was also in leptomeninges, ependymal cells and choroid plexus. Paper-10287748.
The results show that expression of synaptophysin can be maintained during formation of metastases. Paper-5453289.
AIMS: To investigate synaptophysin gene expression in the cerebral cortex in schizophrenia. Paper-2186885.
Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles. Paper-2116869.
Immunohistochemical study on synaptophysin in the spinal cord of chronic anterior poliomyelitis. Paper-287676.
Hippocampal synaptophysin immunoreactivity is reduced during natural hypothermia in ground squirrels. Paper-9734581.
Synaptic vesicle proteins, synaptophysin and chromogranin A in amyotrophic lateral sclerosis. Paper-386314.
Synaptophysin is a protein involved in neurotransmitter exocytosis and is a neuroendocrine marker. Paper-2044932.
Synaptophysin protein and mRNA expression in the human hippocampal formation from birth to old age. Paper-12197335.
The neuroendocrine cells within the bronchial-type epithelium stained for calcitonin and synaptophysin. Paper-12362316.
Synaptophysin: structure of the human gene and assignment to the X chromosome in man and mouse. Paper-16514.
Synaptophysin in choroid plexus epithelial cells: no useful aid in differential diagnosis. Paper-2016944.
The expression of intermediate filaments and synaptophysin in Y79 retinoblastoma cells was studied. Paper-5830457.
Immunoblotting showed a 38 kDa reactivity, which is also the molecular weight of synaptophysin. Paper-12825315.
Two melanomas contained neurofilament-positive tumor cells, which were however negative for synaptophysin. Paper-6498831.
Synaptophysin and chromogranin A immunoreactivities of Lewy bodies in Parkinson's disease brains. Paper-8174911.
In this study, we show that overexpression of synaptophysin enhances the micro-opioid receptor endocytosis. Paper-12381869.
Aberrant neurofilament protein and synaptophysin expression in malignant melanoma of the nasal cavity. Paper-10458768.
In some non-HD patients' colonic specimens SY-positive synapses were present in the muscularis mucosae. Paper-11075577.
Co-localization of synaptophysin with different neuroendocrine hormones in the human gastrointestinal tract. Paper-1778212.
In the ciliary ganglion, upregulation of synaptophysin II mRNA correlates very well with synaptogenesis. Paper-7660618.
Frontal cortical synaptophysin in Lewy body diseases: relation to Alzheimer's disease and dementia. Paper-1421314.
The LCNEC showed organoid and trabecular growth patterns and was positive for chromogranin and synaptophysin. Paper-1976232.
Prognostic significance of synaptophysin in stage I of squamous carcinoma and adenocarcinoma of the lung. Paper-12519735.
Decreased synaptophysin in the medial temporal lobe in schizophrenia demonstrated using immunoautoradiography. Paper-467188.
Synaptophysin is an integral membrane protein of small synaptic vesicles in brain and endocrine cells. Paper-16514.
Synaptophysin expression in the human spinal cord. Diagnostic implications of an immunohistochemical study. Paper-790573.
Synaptophysin: a sensitive and specific marker for ganglion cells in central nervous system neoplasms. Paper-6535869.
Synaptophysin: a sensitive and specific marker for ganglion cells in central nervous system neoplasms. Paper-6536975.
Neuronotypic differentiation results in reduced levels and altered distribution of synaptophysin in PC12 cells. Paper-7639793.
PPNAD nodules and the PPNAD cell line, but not the extranodular adrenal cortex, stained intensely for SYN. Paper-1785224.
Nerve growth factor regulates synaptophysin expression in developing trigeminal ganglion neurons in vitro. Paper-13607810.
Seven days after treatment there was a significant loss of hair cells and synaptophysin-stained area (SSA). Paper-9868977.
Synaptophysin in the human retina and retinoblastoma. An immunohistochemical and Western blotting study. Paper-6441766.
It is the first case report of neoplastic precursor T cell lymphoblasts with unusual expression of synaptophysin. Paper-13696176.
Synaptophysin may act as an important calcium binding protein in the sensory transduction of hair cells. Paper-6159037.
Determination of the base sequence of h-Sp-1 showed a size of 2170 bp and 43.4% homology with human synaptophysin. Paper-9926857.
Synaptophysin was significantly lower in presenile than senile AD in right frontal and bilateral parietal lobes. Paper-9484345.
Thus, rhabdomyosarcomas (0/5), lymphomas (0/4), or Ewing's sarcomas (0/2) were negative for synaptophysin. Paper-5785838.
Ultrastructural distribution of synaptophysin and synaptic vesicle recycling at the frog neuromuscular junction. Paper-679263.
Reduction of the synaptophysin level but normal levels of glycerophospholipids in the gyrus cinguli in schizophrenia. Paper-9434991.
Synaptophysin immunohistochemistry during vestibular hair cell recovery after gentamicin treatment. Paper-9868977.
Glial cells were highlightened by antibodies to GFAP and neuronal cells by chromogranin and synaptophysin markers. Paper-12981951.
We determined synaptophysin concentration from motor cortex in only 4 of our PSP cases, 2 demented and 2 non-demented. Paper-8969413.
In normal liver and chronic hepatitis synaptophysin immunoreactivity was detected in the lobules and portal areas. Paper-8198380.
Synaptophysin gene expression in schizophrenia. Investigation of synaptic pathology in the cerebral cortex. Paper-2186885.
Cholinergic fibers were depleted to 15% of control values, while synaptophysin density was not significantly altered. Paper-7498577.
Calcineurin and synaptophysin in the human spinal cord of normal individuals and patients with familial dysautonomia. Paper-6817412.
Alpha and beta nicotinic acetylcholine receptors subunits and synaptophysin in putamen from Parkinson's disease. Paper-8514128.
Severe panencephalic Pick's disease with Alzheimer's disease-like neuropil threads and synaptophysin immunoreactivity. Paper-7912359.
(4) To determine the synaptophysin and chromogranin immunoreactivity in neuroendocrine tumors arising in various locations. Paper-1560972.
We have studied the endocytic pathway in PC12 cells and localized synaptophysin to a subpopulation of early endosomes. Paper-7675961.
SypI was only weakly detected, mainly in cell somata, before 7 days in vitro, after which it was found in neurites. Paper-13420459.
These findings suggest that the major function of SNAT1 is not to replenish the transmitter pools of Glu and GABA. Paper-10287748.
Immunocytochemical labeling of undifferentiated PC12 cells reveals concentrations of synaptophysin in the perinuclear region. Paper-7639793.
Synaptophysin identified in metastases of neuroendocrine tumors by immunocytochemistry and immunoblotting. Paper-5453289.
Dietary curcumin (2000 ppm), but not ibuprofen, suppressed oxidative damage (isoprostane levels) and synaptophysin loss. Paper-8918827.
The origin of the Merkel cells (MC) being far from clear, this study was performed to establish if normal MC express SY. Paper-5830144.
Changed intestinal distributions of SY-positive synaptic vesicles usually accompany colonic ganglion cell disorders. Paper-11075577.
In temporal cortex (Brodmann area 21), synaptophysin mRNA was decreased in AD and non-AD dementia groups compared to controls. Paper-1414508.
A clinicopathologic and immunohistochemical analysis of 53 cases of medulloblastoma with emphasis on synaptophysin expression. Paper-6537959.
SYN expression was studied with a monoclonal antibody (MAb) by the immunoperoxidase technique in 53 medulloblastomas. Paper-6537959.
In the gastrointestinal tract (except the antrum), chromogranin A is a better general neuroendocrine marker than synaptophysin. Paper-1778212.
No reduction of EAATs or synaptophysin immunostaining was observed in demyelinated cortex in the absence of activated microglia. Paper-12500859.
A patient with diffusely positive staining for both chromogranin A and synaptophysin was diagnosed with neuroendocrine carcinoma. Paper-12103613.
The synaptophysin immunoreactivity revealed connections between the terminals and the neurons of the deep cerebellar nuclei. Paper-1576582.
We identify synaptophysin as a major specifically cholesterol-binding protein in PC12 cells and brain synaptic vesicles. Paper-2116869.
Using a monoclonal antibody, SBI 20.10, we investigated the expression of synaptophysin in the sensory cells of the avian cochlea. Paper-849087.
Interestingly, synaptophysin was downregulated in these MRT cell lines in contrast with the neuroblastoma cell lines. Paper-9308658.
Cholinergic fiber loss occurs in the absence of synaptophysin depletion in Alzheimer's disease primary visual cortex. Paper-7498577.
This prenatal insult caused age-specific changes in accumbal dopamine levels and in synaptophysin expression in the frontal cortex. Paper-13071496.
Temporal cortex synaptophysin mRNA is reduced in Alzheimer's disease and is negatively correlated with the severity of dementia. Paper-1414508.
Synaptophysin was found to be sulfated, which facilitated the determination of its exit route from the trans-Golgi network (TGN). Paper-6994861.
Additionally, fifteen of sixteen neoplasms (93.8%) with MTSCC showed the expression of either chromogranin A or synaptophysin or both. Paper-11377794.
Detection of synaptophysin-producing cells in human thymus by immunohistochemistry and nonradioactive in situ hybridization. Paper-1718188.
These cytoplasmic structures were immunoreactive with antibodies against chromogranin A and synaptophysin in paraffin-embedded tissue. Paper-9358296.
Synaptophysin immunoreactivity in Pick's disease: comparison with Alzheimer's disease and dementia with Lewy bodies. Paper-11617568.
We conclude that SYN is a useful marker for medulloblastomas, indicating that this tumor is a primitive neuronal-neuroblastic neoplasm. Paper-6537959.
The midbrain tumors showed weak reactivity to synaptophysin, and they blended with reactive astrocytes positive for glial markers. Paper-6927372.
Further, SYN mRNA expression was studied by nonradioactive in situ hybridization using digoxigenin-labeled oligonucleotide probes. Paper-207776.
Our data highlight synaptophysin as a sensitive and specific marker of both neuronal lineage and neoplastic character in gangliogliomas. Paper-6536975.
In the normal ureteral mucosa adjacent to the tumor, some endocrine cells positive for chromogranin A and synaptophysin were identified. Paper-13671008.
Synaptophysin staining suggested that these peripheral nerve fibers in the inflammatory areas still contained synaptic vesicles. Paper-8246392.
In AD as compared to controls, a decrease in synaptophysin immunostaining was evident in the terminal zone of the perforant pathway. Paper-7493477.
Transplanted OB precursors gave rise to interneurons with dendritic spines in close proximity to synaptophysin-positive boutons. Paper-12268940.
The interrelationships of synaptophysin, other presynaptic proteins, the cholinergic system, and severity of dementia in AD remain unclear. Paper-9075523.
Synaptophysin expressed in the bronchopulmonary tract: neuroendocrine cells, neuroepithelial bodies, and neuroendocrine neoplasms. Paper-5622848.
Dendritic spines and immunoreactivity of synaptophysin in the frontal cortex of humans with infantile brain damage. A correlative study. Paper-7963843.
Pheochromocytoma was diffusely positive for synaptophysin and chromogranin, whereas staining was focal and punctate in neuroblastoma. Paper-8017180.
An immunohistological study with an antibody to synaptophysin showed that the number of synapses in transplanted ganglia was severely reduced. Paper-1682280.
Immunohistochemical neuronal markers (neurofilament protein, synaptophysin and chromogranin) confirm the presence of a neuronal cell component. Paper-11528914.
The latter structures displayed synaptophysin immunoreactivity, mostly localized to outer membranes of synaptic vesicles and dense bodies. Paper-7191853.
As a marker for the synaptic vesicle-like organelles in this system, we have used the integral membrane glycoprotein p38 or synaptophysin. Paper-6610580.
Newly synthesized synaptophysin is transported to synaptic-like microvesicles via constitutive secretory vesicles and the plasma membrane. Paper-6994861.
The aim was to determine if dementia in Lewy body disease was associated with diminished concentrations of midfrontal cortex synaptophysin. Paper-1421314.
In rats, entorhinal lesions resulted in diminished immunoreactivity for both synaptophysin and NT75 in the perforant pathway terminal zone. Paper-7493477.
In parahippocampal gyrus, the loss of synaptophysin messenger RNA per neuron in schizophrenia was greater in deep than superficial laminae. Paper-400221.
The predicted protein product derived from this clone is truncated, and the tissue distribution of HL-5 is different from that of synaptophysin. Paper-7236524.
In CJD patients with a long clinical course, synaptophysin immunoreactivity decreased, and synaptic PrPCJD accumulated with a wider distribution. Paper-7213729.
Positive SY immunostaining was solely restricted to the neural and sensory structures and did not include supporting cells of the organ of Corti. Paper-10194815.
The synaptic-vesicle-specific proteins rab3a and synaptophysin are reduced in thalamus and related cortical brain regions in schizophrenic brains. Paper-2028121.
Polariscopy, trichrome staining, and immunostaining for synaptophysin were very useful for differentiating spinal cord from peripheral nerve. Paper-8424457.
Expression of intermediate filaments and synaptophysin show neuronal properties and lack of glial characteristics in Y79 retinoblastoma cells. Paper-5830457.
Synaptophysin was expressed in all central neurocytomas and DNTs, in three oligodendrogliomas (43%), and in three oligoastrocytomas (75%). Paper-9266562.
The superficial cellular layer was also diffusely stained for synaptophysin; there was a positive reaction in the linearly arranged myelin sheaths. Paper-6681968.
Quantitative analysis of synaptophysin immunoreactivity in human neocortex after cardiac arrest: confocal laser scanning microscopy study. Paper-1807907.
In most cases, the studied oncocytomas did not react to synaptophysin showing different results from other adenomas of the anterior hypophysis. Paper-6079816.
Histologically, prominent neurocytic rosettes with synaptophysin expression were embedded in a glial tumor component resembling pilocytic astrocytoma. Paper-10047285.
In the ganglionic colon of HD patients and others the immunoreactivity of SY-positive synapses was abundantly present in the smooth muscle layers. Paper-11075577.
PGA/ chitosan grafts were evaluated as (+++) and (++), while PGA grafts were evaluated as (++) and (+) with use of synaptophysin antibody. Paper-13044091.
Quantitative assessment of the synaptophysin immuno-reactivity of the cortical neuropil in various neurodegenerative disorders with dementia. Paper-7831472.
Compared with synaptophysin, NB84 was more sensitive, although less specific, in the identification of neuroblastoma in formaldehyde-fixed tissue. Paper-1346475.
Comparative immunohistochemical study on synaptophysin expression in the anterior horn of post-poliomyelitis and sporadic amyotrophic lateral sclerosis. Paper-898871.
Some immunoreactivity for synaptophysin was also found in the secretory granules of the insulin-producing cells, although it was weaker in this location. Paper-6892470.
Immunostaining of SYN in the cerebral cortex (an area not exhibiting spongiform lesions) was similar in viral infected and age-matched control mice. Paper-109659.
Some adenohypophysial corticotrophs, most corticotrophs spreading to the posterior lobe, and Crooke's hyaline material did not immunoreact with anti- SYP. Paper-5829280.
Both PB and PA were able to increase expression of glial marker glial fibriliary acidic protein and neuronal marker synaptophysin in two cell lines. Paper-10411661.
In contrast, synaptophysin was expressed in both the neonate and adult cochlea; immunoreactivity was found below IHCs around P4 and below OHCs at P5. Paper-831840.
We have determined the structure and organization of the human synaptophysin gene and have established the chromosome localizations in man and mouse. Paper-16514.
Synaptophysin immunoreactivity can be quantified by image analysis to evaluate loss of presynaptic terminals in human neurodegenerative diseases. Paper-341364.
Central neurocytoma is a rare brain tumor composed of small round synaptophysin-positive cells, suggesting a neuronal origin of these tumor cells. Paper-641768.
Synaptophysin, an integral membrane glycoprotein of presynaptic vesicles, was tested as an immuno-histochemical marker for childhood neuroblastoma. Paper-5785838.
Morphometry of synaptophysin immunoreactive ganglion cells in Auerbach plexus in patients with colorectal cancer. Is this a new prognostic factor? Paper-10898271.
Both compounds significantly increased the levels of synaptophysin and tau in cerebral cortex, and PFOA also increased the levels of tau in hippocampus. Paper-13701593.
Increased SYP immunoreactivity was accompanied with degeneration of neuronal cell bodies, their processes and terminals as well as glial cell proliferations. Paper-11307436.
Localization of the glutamine transporter SNAT1 in rat cerebral cortex and neighboring structures, with a note on its localization in human cortex. Paper-10287748.
We report the first case of a patient with precursor T-ALL/T-LBL who presented with cholestatic jaundice and aberrant tumor expression of synaptophysin. Paper-13696176.
Synaptophysin and syntaxin-1 are membrane proteins that associate with synaptic vesicles and presynaptic active zones at nerve endings, respectively. Paper-8997929.
The membrane of these presumptive secretory microvesicles is known to contain synaptophysin, a major integral glycoprotein of neuronal synaptic vesicles. Paper-7809543.
Axon varicosities positive for synaptophysin were present in the adventitia of ICA of young animals but were absent in the ligamentous cord of mature animals. Paper-12326758.
Synaptophysin is an integral membrane protein of synaptic vesicles characterized by four transmembrane domains with both termini facing the cytoplasm. Paper-9185147.
Immunohistochemical markers such as chromogranin A, synaptophysin, and serotonin have proven to be useful diagnostic tools in evaluating carcinoid tumors. Paper-6537945.
Synaptophysin and/or chromogranin A may be expressed in epithelial cells of normal and dysplastic mammary gland and in some cancer of the breast. Paper-1010914.
Immunoelectron microscopy showed synaptophysin expression in the extraskeletal myxoid chondrosarcoma but not in the skeletal chondrosarcoma case. Paper-9107659.
Topology of innervation of labial salivary glands by protein gene product 9.5 and synaptophysin immunoreactive nerves in patients with Sjögren's syndrome. Paper-7505417.
These processes are immunopositive for synaptophysin, and they terminate in two strata occupied by the dendrites of amacrine cells and ganglion cells. Paper-8300321.
However, in some carcinoma cases ChgA and Syn were revealed in carcinoma cells, in myoepithelial cells, in some stromal mesenchymal cells and endothelial cells. Paper-1006686.
Application of high pharmacological doses of estradiol promoted only synaptophysin expression, a presynaptic protein, but did not increase the number of boutons. Paper-11838690.
Reduction of the small synaptic vesicle protein synaptophysin but not the large dense core chromogranins in the left thalamus of subjects with schizophrenia. Paper-2085113.
On the other hand, the reduced synaptophysin' levels in the gyrus cinguli demonstrate that biological differences can be revealed in this relatively small sample. Paper-9434991.
The cells in the adrenocortical micronodules of both cases were stained intensely with antiserum for synaptophysin, whereas the surrounding adrenal cortex did not. Paper-13334409.
The other is the essential role of membrane cholesterol, which specifically interacts with synaptophysin, the major transmembrane protein of synaptic vesicles. Paper-8550313.
RESULTS: Prenatal exposure to ethanol did not alter levels of presynaptic proteins in the hippocampus or levels of synaptophysin in the prefrontal cortex. Paper-11511633.
Two isoforms of the neural cell adhesion molecules were increased in the hippocampus of BD, whereas the synaptic protein marker, synaptophysin, was not changed. Paper-8511231.
The dense ligamentous tissue proper was practically aneural, as was seen in staining for the generalized neuronal markers protein gene product 9.5 and synaptophysin. Paper-7373548.
BACKGROUND: Decreased expression of proteins such as synaptophysin in the hippocampus and prefrontal cortex in schizophrenia is suggestive of synaptic pathology. Paper-2186885.
Synaptophysin is an integral membrane glycoprotein (Mr 38,000) that occurs in presynaptic vesicles of neurons and in similar vesicles of the adrenal medulla. Paper-5246506.
Synaptophysin (ICN, Costa Mesa, California) reactivity was strong in testicular tumor of the adrenogenital syndrome but rarely observed in Leydig cell tumor. Paper-12424689.
Histopathological examination of the specimen revealed positive chromogranin A and synaptophysin stainings compatible with the diagnosis of a carcinoid tumor. Paper-12140885.
By immunohistochemical staining for chromogranin A and synaptophysin, NE cell differentiation was detected in eight of 48 patients (16.7%) with PD adenocarcinoma. Paper-12138335.
A series of nonneuroendocrine tumors, such as adenocarcinomas, sarcomas, lymphomas, and melanomas, were negative for both synaptophysin and NF proteins. Paper-5565102.
Dystrophic neurites were not detected by a modified Bielschowsky stain or by neurofilament, synaptophysin and tau immunohistochemistry in the olfactory mucosa. Paper-946995.
We identified palpable tumor masses (log-rank test, P = 0.0027) and synaptophysin expression (log-rank test, P = 0.0422) as prognostic unfavorable markers for renal PNET. Paper-12082855.
It was evenly distributed throughout the compartment at 14-22 weeks of gestation, and then from 23 weeks to the time of birth, there was a pericellular arrangement of SYN. Paper-9256850.
The other 21 cases of gangliogliomas were originally diagnosed as astrocytoma or mixed glioma, but were shown by synaptophysin staining to be gangliogliomas. Paper-7633103.
Core biopsy of the mass and left axillary lymph node aspiration revealed neuroendocrine tumor of the breast, which stained positive for synaptophysin and chromogranin. Paper-12621731.
As soon as cell migration had finished, the entire cortical plate contained dense synaptophysin immunoreactivity, in a pattern similar to that observed in the adult animal. Paper-7695216.
In the search for proteins regulating mu-opioid receptor (MOPr) endocytosis, synaptophysin was found to bind to the rat micro-opioid receptor in yeast two-hybrid assay. Paper-12381869.
The expression of synaptophysin in epithelial cells of the thymic cortex suggests that this protein may be involved in secretory activities related to T-cell maturation. Paper-1718188.
Synaptophysin, a membrane glycoprotein of presynaptic vesicles, and neurofilament (NF) proteins were tested as immunohistochemical markers for neuroendocrine tumors. Paper-5565102.
Vascular dementia in Spatz-Lindenberg's disease (SLD): cortical synaptophysin immunoreactivity as compared with dementia of Alzheimer type and non-demented controls. Paper-7873073.
Loss of neurons would be expected to lead to the retrograde degeneration of their afferents, which should be reflected in a loss of presynaptic markers such as synaptophysin. Paper-10646095.
In addition, no age-related change in number of synaptophysin-positive boutons was observed in the molecular layer of the dentate gyrus or CA1 region of hippocampus. Paper-1822300.
Poorly differentiated endocrine carcinomas lack large dense core vesicles markers (chromogranin A), while widely express synaptophysin and cytosol endocrine markers. Paper-10238221.
Pineal parenchymal tumor (PPT) differentiation was confirmed by immunohistochemical detection of neuroendocrine markers ( synaptophysin, neurofilaments, and chromogranin A). Paper-9666399.
To assess the synaptic changes in the motor neurons, we examined immunoreactivities for synaptophysin in the spinal cord of 11 patients with Werdnig-Hoffmann disease. Paper-845343.
For example, the reduction in synaptophysin messenger RNA in subicular neurons may be accompanied by decreased density of synaptic terminals in the nucleus accumbens. Paper-400221.
Neuroendocrine differentiation of sparse cells interspersed in the pluristratified epithelium was documented by immunohistochemical staining for chromogranin and synaptophysin. Paper-9035346.
Differentiation markers as an aid in the histological diagnosis of small-cell carcinoma of the lung: synopsis of intermediate filament protein and synaptophysin expression. Paper-5871757.
This revealed the presence of 29 putative exons, organized into three genes, in addition to the 7 exons of the complete SYP coding region, all mapping within a 44-kb interval. Paper-1301901.
The results show that fibrous SYN immunolabelling most probably indicating intra-axonal transport of synaptic vesicles can only be observed during the first half of gestation. Paper-2098786.
Synaptophysin immunoreactivity of the cortical neuropil in vascular dementia of Binswanger type compared with the dementia of Alzheimer type and nondemented controls. Paper-8202230.
Nerve-muscle preparations treated this way exhibited adequate preservation of ultrastructure and revealed the distribution of synaptophysin with high sensitivity and resolution. Paper-1841064.
Preliminary analysis of the latter suggested that this might reflect a high density of coding sequences and we therefore undertook the complete sequencing of a SYP-containing cosmid. Paper-1301901.
Here, we tested whether intra-carotid infusion of bone marrow stromal cells promotes synaptophysin expression and neurological functional recovery after stroke in rats. Paper-12151988.
In the recipient heart cardiac nerve fibers and fascicles displayed immunoreactivity for general neural (protein gene product 9.5 and synaptophysin) and Schwann cell markers (S-100). Paper-6618760.
The biogenesis of synaptic-like microvesicles (SLMVs) in neuroendocrine cells was investigated by studying the traffic of newly synthesized synaptophysin to SLMVs in PC12 cells. Paper-6994861.
VASE immunostaining was also observed in the cytoplasm of CA4 pyramidal neurons that were positive for phosphorylated high molecular weight neurofilament and synaptophysin terminals. Paper-1685435.
We studied the effects of anoxia or hypoxia on 7-day-old rats frontal cortex synaptophysin protein levels assessed by Western blotting 4 and 7 weeks following the exposure. Paper-13555224.
We conclude that the neuroendocrine marker SYN is expressed in a small subset of non-small-cell carcinomas of the cervix and its expression seems to correlate with a poor outcome. Paper-9320176.
SYN protein levels were decreased in individuals with dementia and increased in those with clinical signs of cognitive impairment insufficient for a diagnosis of dementia. Paper-13803670.
BACKGROUND: The prognostic significance of the presence of a neuroendocrine marker ( synaptophysin, SY) was analyzed in stage I of squamous carcinoma and adenocarcinoma of the lung. Paper-12519735.
In myasthenic thymuses, Syn expression was in cortical and medullary epithelial cells, in myoid cells and only scanty and focal in keratinized epithelial cells of Hassall's bodies. Paper-1641019.
To understand the role of the synapsins and synaptophysin in the biology of a nerve cell means to elucidate the fundamental mechanism of brain function, the release of neurotransmitter. Paper-7591783.
The innervation of human cerebral blood vessels has been examined using synaptophysin, a marker of synaptic vesicles, and chromogranin A, a marker of large dense-core vesicles. Paper-304151.
Additionally, the distribution of the SV protein synaptophysin, when expressed by transfection in fibroblastic cells or in polarized epithelial cells (MDCK cells), was investigated. Paper-7816566.
SNAT1 mediates glutamine (Gln) influx into neurons and is believed to replenish the transmitters pools of glutamate ( Glu) and gamma-aminobutyric acid ( GABA). Paper-10287748.
Synaptophysin was consistently present in the tumor cells of pheochromocytomas (10/10), thyroid medullary carcinomas (8/8), and pancreatic islet cell tumors (6/6). Paper-5565102.
Immunochemistry confirmed the cytologic diagnoses of all SmC cases (neck, 16; mediastinum, 9; abdomen, 1; and axilla, 1) with either positive chromogranin or synaptophysin. Paper-10894812.
We report the sequence analysis of a clone, HL-5, isolated from a human erythroleukemia cell cDNA library, that is similar to synaptophysin in DNA and amino acid sequence. Paper-7236524.
In these mice, axonal dilatations with accumulation of synaptophysin, neurofilaments, mitochondria, and vesicles were documented, suggesting impairment of axonal transport. Paper-8587261.
Synaptophysin immunoreactivity, as demonstrated by SY-38, proved very sensitive to prolonged fixation and was of poor quality following formaldehyde and paraformaldehyde fixation. Paper-7652176.
These neurons displayed extensive processes, exhibited immunoreactivity for mature neuron-specific markers such as tau and synaptophysin, and fired action potentials upon current injection. Paper-2129669.
The ballooned neurons in the anterior horns of patients with WHD, S-ALS, L-MND, and axonal reaction had few SP immunoreactive dots or granules around the cell bodies and proximal processes. Paper-651292.
The morphology and course of synaptophysin-positive nerve fibers indicated that synaptic contacts within the spiral ganglion, as observed under the electron microscope, may be abundant. Paper-2173911.
All of the point mutations, like wild-type CLN3, were highly associated with lysosome-associated membrane protein II in non-neuronal cells and with synaptophysin in neuronal cell lines. Paper-2205824.
In addition, an Eco0109 RFLP has been identified and used in genetic mapping of the human SYP locus and supports the order TIMP-SYP-DXS14 within a span of approximately 4-7 centimorgans. Paper-16514.
Electron microscopic examination of synaptophysin immunoreactivity in the developing cerebral cortex of ferrets confirmed that labeling was solely associated with synaptic vesicles. Paper-7695216.
A positive synaptophysin reaction was obtained on the surface of neoplastic neurons in gangliogliomas, as well as on the surface of normal neurons in the encephalon, cerebellum and pons. Paper-11643645.
When certain epithelial non-NE cells, such as human hepatocellular carcinoma PLC cells, were cDNA transfected to synthesize synaptophysin, the new molecules appeared in specific SET vesicles. Paper-8155990.
Early in the developing cerebellar cortex, the expression of NF protein and synaptophysin occurred in discrete patches or columns similar to those described for other antigens (i.e., zebrins). Paper-100054.
By immunohistochemistry a high percentage of senile plaques was found to contain chromogranin A-reactive dystrophic neurites, whereas synaptophysin reactivity within plaques was rare. Paper-7455637.
Finally, electron microscopy showed the presence of small electron translucent vesicles, comparable to the synaptophysin-reactive synaptic vesicles in neurons, in stellate cell projections. Paper-2044932.
We found a decrease in mean synaptophysin concentration in these 8 cases in frontal, temporal, and parietal lobes, and in cerebellum, compared to the means in corresponding lobes of 16 controls. Paper-8969413.
We investigated synaptophysin immunoreactivity (SYN-ir) in the hippocampus after short and long periods of hypothermia and short and long periods of euthermy in hibernating ground squirrels. Paper-9734581.
There were several subsets of neurites that were argyrophilic or immunoreactive against antibodies to either phosphorylated tau protein, phosphorylated neurofilaments, ubiquitin, or synaptophysin. Paper-8275999.
In the same tissues, synaptophysin immunoreactivity was significantly reduced in both the inner and outer molecular layers of the dentate gyrus (both p<0.01 by paired t-test), but not in the hilus. Paper-11135907.
Because SYP is a marker protein for presynaptic vesicles, presynaptic terminals in the inferior olivary nucleus seem to change their distribution during the course of olivary hypertrophy. Paper-8174291.
Histopathological analysis of both tumours showed a strong expression of chromogranin and synaptophysin, thus both were classified as well-differentiated, non-functioning neuroendocrine carcinomas. Paper-13076715.
Similar granular synaptophysin reactivity is seen around heterotopic neurons in the subcortical white matter, in dysgenesis of the cerebellar cortex and in the residual anencephalic forebrain. Paper-1815125.
We identified special histopathological and immunophenotypic features, including synaptophysin staining, which distinguish testicular tumor of the adrenogenital syndrome from Leydig cell tumor. Paper-12424689.
We also measured synaptophysin mRNA in the human subjects and found no age-related changes, except in parahippocampal gyrus wherein the mRNA declined from infancy to adolescence, and again in old age. Paper-12197335.
The results support the genomic composition of Elymus batalinii as SYP and also indicated the presence of at least one H genome in Elymus enysii with a hitherto unknown genomic constitution. Paper-12793275.
In superior cervical ganglion (SCG) cultures, NET surface expression is prominent on varicosities defined by FM1-43 labeling of living neurons or synaptophysin labeling of fixed preparations. Paper-10090657.
By contrast, there was a significant depletion of synaptophysin-positive axon terminals in the substantia gelatinosa and in the dorsal nucleus of Clarke of patients with familial dysautonomia. Paper-6817412.
The apparent molecular mass (approximately 38 kDa) and the extent of glycosylation of platelet-derived synaptophysin was more similar to the neuronal than to the neuroendocrine form of the protein. Paper-6546245.
The consistent expression of synaptophysin and 2 or more neuropeptides indicates that central nervous system PNETs have significant phenotypic features in common with neuroendocrine tumors. Paper-6829145.
Ultrastructural studies and immunohistochemical stains for chromogranin, protein gene product 9.5, and synaptophysin are effective tools for the diagnosis of thymic carcinoid and oat-cell carcinoma. Paper-6127813.
In the spinal cord, fibres immunostained by ME20.4 appeared in a characteristic pattern that differed from the spatial and temporal distributions of synaptophysin- and neurofilament-immunoreactive fibres. Paper-7363558.
These results suggest that a greater fraction of synaptophysin expression within the sensory epithelium depends on the presence of afferent calyceal endings, which are greatly affected by gentamicin. Paper-9868977.
A dense innervation of the myocardium, blood vessels and endocardium was revealed with antisera to general neuronal (protein gene product 9.5 and synaptophysin) and Schwann cell markers (S-100). Paper-6011420.
This protein, for which we propose the name synaptophysin*, provides a molecular marker for the presynaptic vesicle membrane and may be involved in synaptic vesicle formation and exocytosis. Paper-4868162.
In our study, the reaction with synaptophysin and NFP was performed on fragments of normal frontal lobe, pons and cerebellum as well as on fragments of post-operation tumor diagnosed as ganglioglioma. Paper-11643645.
Similar phenotypes are observed in adolescent muscle null for a synaptophysin-family protein named mitsugumin-29 (MG29) that is involved in maintenance of muscle membrane ultrastructure and Ca2+ signaling. Paper-12203654.
Immunoreactivity for neurofilament epitopes and synaptophysin was detected in areas of ganglionic differentiation and coincided with the demonstration of neurofibrils in Bielschowsky's silver impregnations. Paper-2668.
RESULTS: EC labeled with at least one of the studied markers were detected in 47 (34.3%) primary colorectal cancers (30% chromogranin A-positive, 33% synaptophysin-positive and 18% serotonin-positive). Paper-13543698.
In all hippocampal subfields, synaptophysin was lowest in infancy, but did not differ significantly between the older age groups, except in dentate gyrus (DG) where the rise was delayed until adulthood. Paper-12197335.
Choroid plexus epithelium (normal and neoplastic) expresses synaptophysin. A potentially useful aid in differentiating carcinoma of the choroid plexus from metastatic papillary carcinomas. Paper-1818545.
The perikaryon showed intense synaptophysin immunoreativity with a distal process projecting into the fibrous stroma of the RWM displaying structural specializations suggestive of a mechanoreceptor function. Paper-8315926.
Neuropil in the cortex of cortical tubers showed reduced immunoreactivity for synaptophysin in all patients. ' Giant cells' were investigated in the cortex and white matter regions of cortical tubers. Paper-1010864.
A transmission electron microscopy (TEM) study and synaptophysin immunoreactivity analysis of neurons in the human spiral ganglion was performed with particular emphasis on the demonstration of synapses. Paper-2173911.
The homotransplanted tumor was immunopositive for histamine, synaptophysin and protein gene product 9.5, and its cells contained numerous secretory granules that were visualized by electron microscopy. Paper-1042383.
Synaptophysin immunoreactivity was normally distributed throughout the spinal cord gray matter, being highly concentrated in the substantia gelatinosa, the dorsal nucleus of Clarke and the anterior horn. Paper-6817412.
To begin to understand the relationship between cognition and synaptic loss in DLB, we assessed immunoreactivity for the synaptic-terminal specific protein, synaptophysin, in the hippocampus in 14 DLB cases. Paper-12741275.
Overlapping expression of immunohistochemical markers and synaptophysin mRNA in pheochromocytomas and adrenocortical carcinomas. Implications for the differential diagnosis of adrenal gland tumors. Paper-207776.
From these results, it was concluded that alphaTC6 cells accumulate L-glutamate in the synaptophysin-containing vesicles in an ATP-dependent manner and secrete it through a Ca2+-dependent exocytic mechanism. Paper-8758796.
A parallel study in rats showed no effect of haloperidol treatment upon hippocampal synaptophysin messenger RNA, suggesting that neuroleptic treatment does not underlie the reductions found in schizophrenia. Paper-400221.
The mitsugumin29 gene mapped to the mouse chromosome 3 F3-H2 is closely related to the synaptophysin gene in exon-intron organization, which indicates their intimate relationship in molecular evolution. Paper-1534576.
Ultrastructural demonstration of neurohaemal contacts in the internal zone of the median eminence of the Mongolian gerbil ( Meriones unguiculatus): correlation with synaptophysin immunohistochemistry. Paper-6892345.
Using an indirect immunohistochemical method, synaptophysin immunoreactivity (SYN-IR) has been studied in cryostat sections of stellate and thoracic ganglia in human fetuses, neonates, infants and adults. Paper-9040987.
By using well-defined monoclonal antibodies, the distribution of synaptophysin and the glycoprotein Egp-34, the first of its kind, was analyzed immunohistochemically in the fetal and the adult human inner ear. Paper-6159037.
In ALS, the staining intensity for chromogranin peptides and synaptophysin was significantly lower in the ventral horn of ALS patients due to a loss in immunoreactive motor neurons, varicose fibers and varicosities. Paper-13494707.
Although SYP cannot be used as a general marker to identify specifically pituitary cells or adenomas, its demonstration may be helpful in immunocytochemical characterization of some null cell adenomas. Paper-5829280.
Virtually all [35S]sulfate-labeled synaptophysin was found to leave the TGN in vesicles which were indistinguishable from constitutive secretory vesicles but distinct from immature secretory granules and SLMVs. Paper-6994861.
Synaptophysin, a 38-kilodalton glycoprotein found in synaptic vesicle membranes, has been shown to be a sensitive marker of neuroendocrine differentiation in non-central nervous system (CNS) tumors. Paper-6535869.
Synaptophysin, a 38-kilodalton glycoprotein found in synaptic vesicle membranes, has been shown to be a sensitive marker of neuroendocrine differentiation in non-central nervous system (CNS) tumors. Paper-6536975.
For this purpose, immunostaining for synaptophysin, which has previously been shown to selectively label the cell surface of neoplastic ganglion cells, was used to retrospectively examine glioma tumor specimens. Paper-7633103.
Histopathological examination revealed characteristic features of central neurocytoma, including immunoreactivity for synaptophysin, as well as the unusual feature of abundant pigment in the cytoplasm of tumor cells. Paper-10484846.
Surface perikaryal labeling for SYN is not restricted to the neoplastic neurons of ganglion cell tumors and should be cautiously interpreted, particularly when neurosurgical material derives from the spinal cord. Paper-790573.
These data suggest that central neurocytomas may be recognized by synaptophysin immunoreactivity and that the expression of cytoskeletal epitopes indicates that these tumors are well-differentiated neuronal neoplasms. Paper-78573.
Almost all 'neuronal giant cells' and some of the 'indeterminate giant cells' in the white matter showed intense immunoreactivity for synaptophysin: cell borders were surrounded by an intense immunoreactive halo. Paper-1010864.
The overlying and surrounding epithelium of the tumor showed intestinal metaplasia including goblet cells, pseudopyloric glands, Paneth's cells, and chromogranin A and synaptophysin-positive endocrine cells. Paper-1527598.
Decreased synaptophysin immunoreactivity was observed in the anterior horn cell column in all patients with Werdnig-Hoffmann disease and correlated with the degree of degenerative change in the motor neurons. Paper-845343.
METHODS: The presence of endocrine cells (EC) was determined in 137 colorectal cancers using light and electron immunohistochemistry and the immunogold method with chromogranin A, serotonin and synaptophysin. Paper-13543698.
This report concerns the immunohistochemical demonstration of two neuronal Ca2(+)-binding proteins, calcineurin and synaptophysin, in the spinal cord of normal controls and from patients with familial dysautonomia. Paper-6817412.
In fetal labyrinths, a distinct immunoreactivity for synaptophysin occurred in the apical region of both outer and inner hair cells as well as in nerve terminals adjacent to both cochlear and vestibular hair cells. Paper-6159037.
Segregation of met-enkephalin from vesicular acetylcholine transporter and choline acetyltransferase in sympathetic preganglionic varicosities mostly lacking synaptophysin and synaptotagmin. Paper-13935280.
Combining both morphologic and biochemical findings, in HD the number of cholinergic vesicles in the remaining nerve endings seems to be increased as measured by SY, a marker molecule specific for synaptic vesicles. Paper-1598208.
Density of dendritic spines on the apical dendrites of layer V pyramidal neurons (Brodman area 10) was analysed in correlation to the density of synaptophysin-reactive granules (counts/microns 2) in the same region. Paper-7963843.
This study concerns the expression of synaptophysin in the hippocampal formation of normal controls, of patients with Alzheimer's disease (AD) and of patients with parkinsonism-dementia complex on Guam (P-D complex). Paper-6814332.
No synaptophysin was detected in blood plasma in humans, not even during an embolisation treatment of tumour metastases in the liver, which induced tumour cell necrosis, in a patient with carcinoid tumours. Paper-7905429.
The present study examined the potential role of synaptic alterations in this process by using an animal model of immature head injury to define the impact of TBI on expression of the synaptic protein, synaptophysin. Paper-13425827.
Synaptophysin reactivity is strong at the surface of neurons but not detected in their somatic cytoplasm; coarsely beaded reactivity within the neuropil probably corresponds to synaptic vesicles in terminal axons. Paper-1815125.
In fact, we found that in three cases of typical SLD type II the synaptophysin immunoreactivity of the cortical neuropil in areas without overt infarcts or scar formation was as much reduced as in Alzheimer's disease. Paper-7873073.
Moreover, the regions around the cell bodies of some ectopic and orthotopic Purkinje cells were intensely immunoreactive with an antibody to synaptophysin, which suggests an abnormal increase in presynaptic terminals. Paper-1829142.
Four weeks later the subsequent axonal sprouting in the dentate gyrus was analysed, by measuring the density of the synaptophysin immunocytochemical staining in the termination area of the entorhinal cortex axons. Paper-9419952.
Following a 7- to 8-day exposure to dibutyryl cAMP (dbcAMP), NG108-15 cells exhibited a neuron-like morphology associated with the expression of the neuronal protein, synaptophysin, and with increased NADPH-d activity. Paper-9250739.
Immunogold labeling of the pancreatic islets in humans by means of monoclonal antibodies to synaptophysin resulted in a distinct localization of gold particles to the secretory granules of glucagon-immunoreactive cells. Paper-6892470.
In the second group six cerebral and midbrain tumours were composed of small cells, which showed apparent neuronal differentiation including positive immunoreactivity for synaptophysin and the presence of synaptic structures. Paper-8842409.
Pathologic quiz case: patient with chronic obstructive pulmonary disease. Diffuse pulmonary neuroendocrine hyperplasia with multifocal tumorlets, immunoreactive to synaptophysin, associated with pulmonary emphysema. Paper-2087804.
Synaptophysin (a presynaptic vesicle protein) levels were quantified by immunoblotting of synaptic membrane fractions isolated from hippocampus, entorhinal cortex, caudate nucleus, and occipital cortex. Paper-1131286.
SY and NF-immunorective nerve fibers were distributed throughout the myenteric plexus of the normal esophagus, but the scarcity of these immunoreactive nerve fibers in the atretic esophagus was apparent. Paper-13306634.
To do this, we targeted synaptophysin messenger RNA with a 35S-labelled oligonucleotide probe in autoclaved, formalin-fixed, paraffin wax-embedded sections of the hippocampal formation of 11 schizophrenics and 11 controls. Paper-2002040.
Consistent with a deficit in kinesin-I-mediated fast axonal transport, densities of synaptophysin- and syntaxin-I-containing vesicles and mitochondria were reduced in neuritic processes of KIM146V hippocampal neurons. Paper-9661157.
As an index of synaptic regulation during such changes, we have examined the expression of a synaptic vesicle protein, synaptophysin, in the cochlear nucleus following a damaging acoustic stimulus in adult chinchillas. Paper-9577637.
Of the ETNFs, one demonstrated synaptophysin expression and neural ultrastructures but lacked genetic alterations, whereas the other showed allelic loss on 1p and 19q but was negative immunohistochemically and ultrastructurally. Paper-9266562.
RESULTS: There were significant decreases in both NeuN and synaptophysin after 1 day and 1 week but not 1 month after injury within the hippocampus and neocortex adjacent to the impact site compared to sham-injured controls. Paper-13425827.
Immunohistochemical detection of synaptophysin played a crucial role in identifying the neuronal nature of these neoplasms and was instrumental in distinguishing them from oligodendrogliomas, with which they are readily confused. Paper-911804.
In contrast to GFP-tagged synaptophysin that moved as vesicles at 1 microm/sec predominantly in the anterograde direction in the typical style of fast axonal transport, the two ER proteins did not move in a discrete vesicular form. Paper-9040787.
The effects of betamethasone on neuronal development and function were determined in the fetal baboon brain by examination of cytoskeletal microtubule associated proteins (MAPs) and the presynaptic marker protein synaptophysin. Paper-9784114.
MATERIALS AND METHODS: Forty-three NE breast carcinomas immunocytochemically positive for chromogranins and/or synaptophysin in > or = 50% of cells were graded following the Elston and Ellis grading system for breast carcinomas. Paper-8936527.
A decrease in synaptophysin expression was observed in the anterior horn neuropil of all motor neuron disease patients and this reduction was correlated with the degree of degeneration or neuronal loss of anterior horn cells. Paper-8091580.
Surgery revealed the presence of an adrenal cortical adenoma with positive staining for the neuroendocrine marker synaptophysin, but negative for chromogranin, as has been previously reported for these rare cortical phaeochromocytomas. Paper-10025570.
Synaptophysin was expressed in the non-neoplastic Sertoli and Leydig cells, 45% of the Sertoll cell tumors, and 70% of the Leydig cell tumors, in approximately similar proportions between the benign and malignant Leydig cell tumors. Paper-1611731.
These granular cells co-expressed neuronal immunohistochemical markers, including synaptophysin, chromogranin, and Neu-N, and demonstrated accumulation of lysosomes and dense core granules in the same cells at the ultrastructural level. Paper-12369123.
Synaptophysin, a synaptic vesicle protein and a marker for synaptic density has been found to be reduced in postmortem prefrontal cortex of schizophrenia patients, consistent with evidence for synaptic deficits in schizophrenia. Paper-13555224.
Synaptophysin in serotonin organelles from rabbit platelets, as suggested for small synaptic vesicles in neurons, might play a role in the formation of protein channels for the exocytotic release of serotonin. Paper-6546245.
Stimulation with cyclic AMP analogs also produces neuronotypic differentiation of PC12 cells, and the degree of morphologic differentiation induced by these agents parallels their ability to effect reduction in synaptophysin levels. Paper-7639793.
The density of glutamate immunolabeling in pinealocytes varied among individual cells and was mostly paralleled by the density of immunostaining for synaptophysin, a major integral membrane protein of synaptic and synaptic-like vesicles. Paper-8186618.
The observed decrease in SP expression around ballooned neurons in these disorders is indicative of a disconnection of presynaptic terminals of afferent fibers from the proximal portion of the swollen degenerated anterior horn cells. Paper-651292.
Synaptophysin immunoreactivity and transmission electron microscopy have demonstrated vesiculated nerve endings synapsing on the supranuclear zone of outer hair cells and also of Deiters' cells in the human organ of Corti. Paper-8200506.
Developmental pattern and distribution of nerve growth factor low-affinity receptor immunoreactivity in human spinal cord and dorsal root ganglia: comparison with synaptophysin, neurofilament and neuropeptide immunoreactivities. Paper-7363558.
We found in 9 cases of vascular dementia of Binswanger type a significant reduction in synaptophysin immunoreactivity of the cortical neuropil (9.1%), the magnitude of which was not much less than in Alzheimer type dementia (10.9%). Paper-8202230.
CONCLUSIONS: Undifferentiated carcinomas of the urinary bladder and prostate should be analyzed not only by means of hematoxylin and eosin but also by immunohistochemical staining for Chr A and SNP to demonstrate a neuroendocrine origin. Paper-9553132.
Although light microscopic features of neuroendocrine (NE) differentiation were not present, staining for CGA and/or SYN was identified in 5/17 (29%) large cell carcinomas (LCC) and 4/19 (21%) poorly differentiated adenocarcinomas (PDA). Paper-6508283.
Synaptophysin, a 38-kDa glycoprotein, is one of the most abundant integral membrane proteins of small presynaptic vesicles and is a useful marker for sites of synaptic transmission of the efferent olivocochlear system in the cochlea. Paper-10194815.
Synaptophysin is an integral membrane glycoprotein with an Mr of 38,000 that occurs in the small, clear vesicles present in neuronal cells and tumors as well as in pancreatic islet cells and various neuroendocrine (NE) carcinomas. Paper-5622848.
Sections of healthy human pancreatic tissue were imaged to visualize synaptophysin in neuroendocrine cells, and sections from human lymph node and liver invaded by metastatic melanoma to localize the cancer markers PS100 and HMB45 simultaneously. Paper-13133534.
The immunoreactivities for both proteins were found in the immature photoreceptor, amacrine and ganglion cells; however, synaptophysin was differentially localized in bipolar cells and their axons, and syntaxin was present in some horizontal cells. Paper-8997929.
Using an improved fluorescent reporter comprising pHluorin fused to synaptophysin, we find that only a slow mode of endocytosis (tau = 15 s) operates at hippocampal synapses when vesicle fusion is triggered by a single nerve impulse or short burst. Paper-12234843.
The messenger RNA encoding synaptophysin, a presynaptic terminal protein, is reduced in the medial temporal lobe in the disease, but immunocytochemical and immunoblotting data have not produced clear evidence for a loss of the encoded protein. Paper-467188.
Our findings suggest that expression of pNFP and synaptophysin by ballooned neurons may reflect axonal impairment and that the presence of alpha B-crystallin, srp 27 and ubiquitin may be related to the degenerative processes that neurons undergo in CJD. Paper-7533143.
In this study, the authors tentatively defined small cell neuroendocrine carcinoma (SCNEC) as a tumor composed of small cells with at least two of the following: argyrophilic cytoplasm, chromogranin A immunoreactivity, and synaptophysin immunoreactivity. Paper-10651256.
Detection of synaptophysin messenger RNA broadens the range of methods by which synaptic protein gene products can be studied and used as markers of synaptic density and synaptic involvement during physiological and pathological processes in human brain. Paper-8029258.
Along the corticospinal tract, there were severe axonal loss and numerous axonal spheroids, which were positive for phosphorylated neurofilament, ubiquitin, and synaptophysin, and lipid-laden macrophages in the centrum semiovale to the crus cerebri. Paper-1183178.
The pseudopapillae were composed of thick hyalinized vessels enclosed by a single layer of glial fibrillary acid protein-positive astrocytes and variously sized synaptophysin-positive and chromogranin-negative neuronal cells in the interpapillary regions. Paper-12042963.
In this work, we have quantified acetylcholinesterase fiber density and the density of an immunohistochemical reaction for synaptophysin as measures of cholinergic and total synaptic loss, respectively, in the primary visual cortex of AD and control cases. Paper-7498577.
We determined immunoreactivity for the synaptic-terminal specific protein synaptophysin in the outer molecular layer of the hippocampal dentate gyrus (OMDG) in eight PiD, nine AD, nine dementia with Lewy bodies (DLB), and seven control cases. Paper-11617568.
Since this tumour can be confused with an oligodendroglioma or an ependymoma on routine histopathology (as happened in seven of our cases); immunohistochemical studies with synaptophysin should be routinely performed for intraventricular glial tumours. Paper-9211293.
The mRNA data indicate that the maturational increases in synaptophysin protein are either translational rather than transcriptional in origin, or else are secondary to mRNA increases in neurons, the cell bodies of which lie outside the hippocampal formation. Paper-12197335.
Our results indicate that anti- synaptophysin antibody detected immunoreactive material in nerve fibers around vessels located in major thymic septa, in a relevant number of cortical epithelial cells, and in scattered epithelial cells in the medulla. Paper-1718188.
Colocalisation of synaptophysin has been studied in different neuroendocrine cell types in histologically normal mucosa from human gastrointestinal tract (corpus, antrum, duodenum, ileum and colon) using double-immunofluorescence stainings. Paper-1778212.
This study concerns the synaptophysin expression in anterior horn neurons of 15 patients with amyotrophic lateral sclerosis and of 4 patients with lower motor neuron disease, who had no upper motor neuron and corticospinal tract involvement. Paper-8091580.
Neuroendocrine markers (chromogranin A and synaptophysin) may be positive in papillary carcinoma, particularly in the solid type, and there may be some overlap with the ductal carcinoma in situ with spindle cells or endocrine ductal carcinoma in situ. Paper-13739451.
Acetone-fixed frozen sections of 15 malignant melanomas of the skin with metastases were studied immunohistochemically for the presence of different types of intermediate filament proteins, synaptophysin, muscle cell actins, and desmoplakins. Paper-6498831.
Cytologic features in 16 histologically confirmed LCNECs in fine-needle aspiration biopsies, cell blocks, bronchial brushes, washes, and sputum specimens stained with Diff-Quik, Papanicolaou, hematoxylin-eosin, chromogranin, and synaptophysin were analyzed. Paper-8683884.
A new synaptic vesicle membrane protein (svp25) of Mr 25,000 with properties similar to synaptophysin as well as a synaptic vesicle binding phosphoprotein of the presynaptic membrane (Mr 92,000) likely to be involved in vesicle exocytosis are described. Paper-6256314.
Cases 3-5, as well as 7 of the 33 screened ependymomas, showed a suggestion of neuronal differentiation by immunohistochemistry alone, including immunoreactivity for Neu-N (n = 8), synaptophysin (n = 4), neurofilament protein (n = 4), and chromogranin (n = 2). Paper-13100829.
We propose that specific interactions between cholesterol and SLMV membrane proteins, such as synaptophysin, contribute to both the segregation of SLMV membrane constituents from plasma-membrane constituents, and the induction of synaptic-vesicle curvature. Paper-2116869.
The latter findings may prove useful in differentiating choroid plexus carcinomas from metastatic papillary carcinomas of extracerebral origin with the exception of neuroendocrine carcinomas of various sites that are usually positive for synaptophysin. Paper-1818545.
Morphometric analysis of synaptophysin immunoreactive ganglion cells in Auerbach plexus in colorectal cancer may be a new useful marker for the description of changes in the intestinal nervous system as well as a prognostic factor for colorectal cancer. Paper-10898271.
A distinction in staining between large perisomatic structures and smaller puncta in the neuropil and between the dorsal and the ventral zones of the ventral cochlear nuclei revealed some variations in the response and degree of recovery of synaptophysin staining. Paper-9577637.
Univariate analyses revealed only a very weak negative correlation between the density of beta A4-immunoreactive cortical plaques and the intensity of the synaptophysin staining, while in a multivariate analysis the plaque density did not show any impact on the latter. Paper-7831472.
We studied synaptophysin immunohistochemical expression in 35 human liver specimens (normal and different pathological conditions), in rat models of galactosamine hepatitis and carbon tetrachloride-induced cirrhosis, and in freshly isolated rat stellate cells. Paper-2044932.
METH-using patients with HIVE showed significantly lower gp41 scores and less severe forms of encephalitis but a higher frequency of ischemic events, a more pronounced loss of synaptophysin immunoreactivity, and a more severe microglial reaction than HIVE non-METH users. Paper-10170541.
This study has characterized the developmental profiles of the vesicular glutamate transporters (VGLUTs) and the synaptic vesicle proteins synapsins and synaptophysin in cerebellar granule cells and in co-cultures containing both granule cells and astrocytes. Paper-11841043.
Synaptophysin immunoreactivity was studied in paraffin-embedded sections of the central nervous system (CNS) in 14 normal human fetuses and neonates ranging in age from 8 to 41 weeks gestation, and in three brains with heterotopic neurons or malformations. Paper-1815125.
To assess the validity of this criterion in the evaluation of intramedullary neoplasms, we screened formalin-fixed, paraffin-embedded sections from 35 histologically unremarkable spinal cords (removed at autopsy) using commercially available monoclonal antibodies to SYN. Paper-790573.
In the AA group in the distal part of the atretic rectum (at the place where the fistula was cut) SY-positive synapses were present in smooth muscle layers and small dysplastic ganglions were seen in the submucosal and muscular region, but not in large numbers. Paper-11075577.
Synaptophysin was also demonstrated in several adenomas of the hypophysis and parathyroids, in the majority of carcinoids of the bronchopulmonary and gastrointestinal tracts, and in many, though not all, NE carcinomas of the same sites, and of the skin. Paper-5781447.
We have studied synaptophysin messenger RNA in the neocortex, hippocampus and cerebellum using in situ hybridization histochemistry to see if the encoding transcript can be detected in post mortem human brain and to investigate factors which might influence its abundance. Paper-8029258.
It has been shown recently that in Alzheimer's disease the degree of dementia is strongly correlated with a reduction of the synaptophysin reactivity of the cortical neuropil as a measure of synapse density, while counts of neuritic plaques showed a weak correlation. Paper-8202230.
Immunofluorescence microscopy revealed that synaptophysin was compartmentalized in intact rabbit platelets and immuno-electron microscopy of subcellular fractions showed that it was localized exclusively to the membrane surface of serotonin organelles. Paper-6546245.
As there is only scarce evidence for a genetic linkage between synaptophysin's chromosomal locus (Xp11.22) and schizophrenia, we hypothesized that early neonatal exposure of rat pups to oxygen restriction would result in reduced frontal cortex synaptophysin protein levels at adulthood. Paper-13555224.
We therefore conclude that, despite the distinct morphological phenotype, no significant changes in gene expression are detectable in synaptophysin-deficient animals and that therefore compensatory mechanisms are either pre-existent and/or act at the posttranscriptional level. Paper-11806315.
The pattern of SY-positive synapses distribution in circular and longitudinal colonic muscles and intermuscular ganglions can reflect functional disturbances of large bowel motility and could be helpful in the description of the innervation status of colonic specimens in HD patients. Paper-11075577.
The PNET component revealed immunopositivity for synaptophysin and neurofilament and showed cells with delicate intercellular junctions, profiles of rough endoplasmic reticulum, mitochondria, and dense core granules, and cell processes with microtubules and neurofilaments. Paper-947489.
Control sections of formalin fixed paraffin embedded cervical (C7/8), thoracic (T10) and lumbar spinal cord (L5) and C6, C7, C8 and L5 of ALS cases were stained with haematoxylin and eosin, luxol fast blue (LFB), and immunostained with a mouse monoclonal antibody against Sph. Paper-11685511.
A correlative investigation of synaptophysin (a major integral membrane protein of small synaptic vesicles) immunoreactivity at the light microscopical level demonstrated a conspicuously dense immunostaining around portal capillaries in both EZ and IZ of the proximal and distal ME (neural stalk). Paper-6892345.
The small, darkly staining cells comprising the first population stained positively for synaptophysin, showing them to be neuroblasts, and the large epithelioid cells comprising the second cell population stained positively with the antibodies HMB-45 and NKI-Beteb, showing them to be melanocytes. Paper-738838.
The files of the Division of Neuropathology of New York University Medical Center contained 45 tumors that had been diagnosed as ganglioglioma, of which 42 were verified by synaptophysin; three cases were reclassified, two as astrocytomas and one as a gangliocytic paraganglioma. Paper-7633103.
The main differential diagnostic consideration was well-differentiated neuroendocrine neoplasm ( carcinoid tumor); positive immunostaining with antibodies against chymotrypsin and trypsin and negative immunostaining with antibodies against synaptophysin and chromogranin helped exclude this diagnosis. Paper-12953379.
Previous neuropathological and morphometric studies of the cerebral cortex of patients with human immunodeficiency virus encephalitis (HIVE) have shown a decrease in the population of large neurons, moderate loss in synaptophysin immunoreactivity, and pathological changes in dendrites. Paper-7246939.
By indirect immunofluorescence microscopy of cryostat sections, using the monoclonal antibody SY 38 to synaptophysin, a consistent positive immunoreactivity was observed in all medulloblastomas (n = 6) and neuroblastomas (n = 3) as well as a ganglioneuroma and a glioneuronal hamartoma. Paper-5459276.
Our data suggest that the alterations in synaptophysin expression occurring in ALS are mainly associated with the loss of lower motor neurons, and that the occasional increased perikaryal expression may be due to the neuronal atrophy, compensatory accumulation or abnormal synaptic vesicle degradation. Paper-8161273.
Expression of synaptic proteins was relatively preserved in the dentate nucleus, although synaptophysin immunohistochemistry disclosed large coarse pericellular terminals in Creutzfeldt-Jakob disease, instead of the fine granular terminals in control cases, around the soma of dentate neurons. Paper-8395579.
Here we show that prenatal LPS administration throughout pregnancy causes maturation-dependent PPI deficits and age-dependent alterations in dopamine activity, as well as in synaptophysin expression and cytokine levels.Molecular Psychiatry advance online publication, 15 April 2008; doi:10.1038/mp.2008.44. Paper-13071496.
Our data suggest that the function of OPCA Purkinje cells is impaired from the peripheral dendrites toward the cell bodies, and that the presence of aberrant phosphorylation of neurofilament proteins, synaptophysin and alphaB-crystallin may be related to the degeneration of Purkinje cells in OPCA. Paper-1578993.
Synaptic vesicle recycling after intense acetylcholine ( ACh) release was studied at the frog neuromuscular junction (NMJ) using the synaptic vesicle transmembrane protein synaptophysin as immunocytochemical marker of the synaptic vesicle membrane during the process of exo-endocytosis. Paper-679263.
Fifty-four formalin-fixed and paraffin-embedded intraocular retinoblastoma specimens and three human eyes enucleated because of orbital tumors were studied for the presence of synaptophysin, a neuron-associated integral membrane glycoprotein of presynaptic vesicles, by using the monoclonal antibody SY38. Paper-6441766.
In the present study we assess the synaptic integrity of thalamus by means of examining the protein levels of: (1) synaptophysin, a membrane bound protein of small synaptic vesicles, and (2) chromogranins, a family of soluble secretory proteins stored and released from the secretory large dense-core vesicles. Paper-2085113.
Surface perikaryal labeling on immunohistochemical assay for synaptophysin (SYN)--a glycoprotein component of synaptic vesicle membranes--has been posited to distinguish the neoplastic neuronal elements of gangliogliomas from native central nervous system neurons overrun by gliomas invasive of gray matter. Paper-790573.
The results show that in L-MND there is decreased SP immunoreactivity of the anterior horn neuropil, but preservation of immunoreactive dots around the cell body and proximal processes, and the presence of some residual neurons in the affected gray matter that are surrounded by a dense accumulation of immunoreaction products. Paper-7936281.
Up to approximately 40% of the [35S]sulfate-labeled synaptophysin eventually (after 3 h and later) reached SLMVs, which could be distinguished from the other post-TGN compartments by their lower buoyant density in a sucrose gradient and their selective inclusion upon permeation chromatography using a controlled-pore glass column. Paper-6994861.
These electrophysiological data correlated in the epileptic subiculum with (i) reduced levels of mRNA expression and immunoreactivity of the neuron-specific potassium-chloride cotransporter 2; (ii) decreased number of parvalbumin-positive cells; and (iii) increased synaptophysin (a putative marker of sprouting) immunoreactivity. Paper-12248277.
In this study, the integral synaptic vesicle protein synaptophysin, measured immunoautoradiographically, was used as an index of synaptic terminal abundance in the hippocampal formation of 37 subjects from 5 weeks to 86 yr old, divided into 4 age groups (10 infants, 15 adolescents/young adults, 6 adults, and 6 elderly). Paper-12197335.
In line with a prolonged efferent synaptic transmission onto Ca(V)1.3 deficient IHCs, which normally ceases around onset of hearing, we found juxtaposed immunoreactive spots of efferent presynaptic synaptophysin and postsynaptic (IHCs) small conductance Ca(2+)-activated potassium channels (SK channels) up to six weeks after birth. Paper-12183111.
To correlate the expression of neuro-endocrine (NE) markers with the presence of somatostatin receptors (SSR) in human breast cancer, a series of 100 cases was stained with the Grimelius silver procedure, by immunocytochemistry with specific NE markers (i.e., chromogranin A and B and synaptophysin) and by autoradiography for SSR. Paper-6359362.
Upon appropriate induction, 100% of 1C11 precursor cells develop neurite extensions and acquire neuronal markers (N-CAM, synaptophysin, gammagamma-enolase, and neurofilament) as well as the general functions of either serotonergic (1C11*(/5HT)) (5HT, 5-hydroxytryptamine) or noradrenergic (1C11**(/NE)) (NE, norepinephrine) neurons. Paper-2186299.
Average synaptophysin levels were reduced in hippocampus when comparing definite AD to controls (55%, p < 0.0001), p-AD to control (25%, p < 0.005), and definite AD to p-AD (30%, p < 0.05), but levels in entorhinal cortex, occipital cortex, and caudate nucleus were either unchanged or less significantly altered than in hippocampus. Paper-1131286.
We strongly recommend staining of any myxoid or glandular tumour of the adrenal gland for alpha-inhibin and synaptophysin (probably the currently best characterised markers of adrenocortical origin) before considering alternative (probably more common) diagnoses of metastatic adenocarcinoma or retroperitoneal tumours localised to the adrenal gland. Paper-10877115.
Synaptophysin immunoreactivity was preserved in the proximal dendrites and around the somata of the remaining normal-appearing neurons, but it was reduced around the somata and dendrite, especially the distal portion of the proximal dendrites of small degenerated neurons with central chromatolysis, pigmentary atrophy, or simple neuronal atrophy. Paper-8091580.
By contrast, the synaptophysin demonstrated no statistically significant changes in expression at 3 or 7 days but demonstrated statistically significant increases at 14, 30, and 60 days in the forelimb, hindlimb, and parietal neocortical regions ipsilateral to the infarction as well as increased distribution in the contralateral parietal neocortex. Paper-1633102.
These synonyms are used for gene SYP (synaptophysin): Synaptophysin, Major synaptic vesicle protein p38.
These accession numbers are used for gene SYP: CAA29686 (NCBI_GENBANK__AC), B7Z359 (UNIPROT__AC), B2R7L6 (UNIPROT__AC), AAB92358 (NCBI_GENBANK__AC).
SYP is a homologue of sypa (synaptophysin a) from Danio rerio.
SYP is a homologue of SYP (synaptophysin) from Bos taurus.
SYP is a homologue of SYP (synaptophysin) from Pan troglodytes.
SYP is a homologue of SYP (synaptophysin) from Canis lupus familiaris.
SYP is a homologue of Syp (synaptophysin) from Mus musculus.
SYP is a homologue of Syp (synaptophysin) from Rattus norvegicus.
Important links !
iHOP - Information Hyperlinked over Proteins .
Concept & Implementation by Robert Hoffmann.