![]() |
The most recent information on
SYP is here.
Click here for the function of SYP. Edit this page in WikiGenes - SYP. The epithelial cells of some thymomas also express Syn. Paper-1641019. Syn density was almost identical across the three genotypes. Paper-2099412. Synaptophysin immunohistochemistry in the human cochlea. Paper-10194815. Synaptophysin expression in the striatum in Huntington's disease. Paper-6530190. Synaptophysin in the cochlear nucleus following acoustic trauma. Paper-9577637. The first report of the Systolic and Pulse Pressure ( SYPP) Working Group. Paper-2135916. Synaptophysin. A new marker for pancreatic neuroendocrine tumors. Paper-5483192. For this purpose, antibodies to substance P and to synaptophysin were used. Paper-6656793. Synaptophysin and NF were present in the large rosettes of pineocytomas. Paper-8180990. Melatonin also inhibits the secretion of synaptophysin in PC12 cells. Paper-1860639. The cDNA and derived amino acid sequences for rat and human synaptophysin. Paper-5454051. All four carcinoid tumors were immunoreactive with chromogranin and synaptophysin. Paper-9411744. About 30% of the stromal cells showed a weak cytoplasmic synaptophysin positivity. Paper-6190617. The development of synaptophysin immunoreactivity in the human sympathetic ganglia. Paper-9040987. Additionally, synaptophysin may be a specific marker for some central neurocytomas. Paper-7103290. Use of synaptophysin immunohistochemistry in intestinal motility disorders. Paper-11075577. On immunochemistry, the tumor stained positive for chromogranin A and synaptophysin. Paper-12258279. Sorting of synaptophysin into special vesicles in nonneuroendocrine epithelial cells. Paper-8155990. Synaptophysin has a selective distribution in early endosomes of PC12 cells. Paper-7675961. Synaptophysin staining in normal brain: importance for diagnosis of ganglioglioma. Paper-1418512. Synaptophysin regulates clathrin-independent endocytosis of synaptic vesicles. Paper-8457618. Three common amino acid motifs ( SYP, TYVS and VRH) were found among these eight sequences. Paper-952285. Tyrosine phosphorylation of synaptophysin in synaptic vesicle recycling. Paper-11182566. Most pituitary adenomas, including null cell adenomas, immunostained with SYP. Paper-5829280. In addition, antibodies to Syn stained nerve structures surrounding the thymic blood vessels. Paper-1641019. Synaptophysin reactivity was present in 10 phaeochromocytomas and in the 8 paragangliomas. Paper-7655160. Immunocytochemical studies on synaptophysin in the anterior horn of lower motor neuron disease. Paper-7936281. Synaptophysin was labeled using silver-intensified immunogold in dissociated muscle fibers. Paper-679263. Synaptophysin immunoreactivities were also similar in Parkinson's disease and control cases. Paper-8514128. All tumors were negative for leukocyte common antigen, muscle-specific actin, and synaptophysin. Paper-47512. A second population of low-density vesicles contains synaptophysin but not hGH or norepinephrine. Paper-6743920. Immunocytochemical localization of synaptophysin in human hypophyses and pituitary adenomas. Paper-5829280. Expression of a kinase anchoring protein 79 and synaptophysin in the developing human red nucleus. Paper-9256850. The results show that expression of synaptophysin can be maintained during formation of metastases. Paper-5453289. AIMS: To investigate synaptophysin gene expression in the cerebral cortex in schizophrenia. Paper-2186885. Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles. Paper-2116869. Immunohistochemical study on synaptophysin in the spinal cord of chronic anterior poliomyelitis. Paper-287676. Hippocampal synaptophysin immunoreactivity is reduced during natural hypothermia in ground squirrels. Paper-9734581. Synaptic vesicle proteins, synaptophysin and chromogranin A in amyotrophic lateral sclerosis. Paper-386314. Synaptophysin is a protein involved in neurotransmitter exocytosis and is a neuroendocrine marker. Paper-2044932. Synaptophysin protein and mRNA expression in the human hippocampal formation from birth to old age. Paper-12197335. Usefulness of synaptophysin immunohistochemistry in an adult case of choroid plexus carcinoma. Paper-8596578. The neuroendocrine cells within the bronchial-type epithelium stained for calcitonin and synaptophysin. Paper-12362316. In this study, we show that overexpression of synaptophysin enhances the mu-opioid receptor endocytosis. Paper-12381869. Synaptophysin: structure of the human gene and assignment to the X chromosome in man and mouse. Paper-16514. Synaptophysin in choroid plexus epithelial cells: no useful aid in differential diagnosis. Paper-2016944. The expression of intermediate filaments and synaptophysin in Y79 retinoblastoma cells was studied. Paper-5830457. Synaptophysin and chromogranin A immunoreactivities of Lewy bodies in Parkinson's disease brains. Paper-8174911. Two melanomas contained neurofilament-positive tumor cells, which were however negative for synaptophysin. Paper-6498831. Synaptophysin immunoreactivity was determined in the left cingulate gyrus from the same patient groups. Paper-1465330. Aberrant neurofilament protein and synaptophysin expression in malignant melanoma of the nasal cavity. Paper-10458768. Co-localization of synaptophysin with different neuroendocrine hormones in the human gastrointestinal tract. Paper-1778212. In the ciliary ganglion, upregulation of synaptophysin II mRNA correlates very well with synaptogenesis. Paper-7660618. The LCNEC showed organoid and trabecular growth patterns and was positive for chromogranin and synaptophysin. Paper-1976232. Decreased synaptophysin in the medial temporal lobe in schizophrenia demonstrated using immunoautoradiography. Paper-467188. Prognostic significance of synaptophysin in stage I of squamous carcinoma and adenocarcinoma of the lung. Paper-12519735. Synaptophysin is an integral membrane protein of small synaptic vesicles in brain and endocrine cells. Paper-16514. Synaptophysin expression in the human spinal cord. Diagnostic implications of an immunohistochemical study. Paper-790573. Synaptophysin: a sensitive and specific marker for ganglion cells in central nervous system neoplasms. Paper-6535869. Synaptophysin: a sensitive and specific marker for ganglion cells in central nervous system neoplasms. Paper-6536975. Neuronotypic differentiation results in reduced levels and altered distribution of synaptophysin in PC12 cells. Paper-7639793. PPNAD nodules and the PPNAD cell line, but not the extranodular adrenal cortex, stained intensely for SYN. Paper-1785224. Seven days after treatment there was a significant loss of hair cells and synaptophysin-stained area (SSA). Paper-9868977. The localization of synaptophysin in the organ of Corti of the human as shown by immunoelectron microscopy. Paper-7847030. Both types of lesion resulted in synaptophysin upregulation in contralateral and ipsilateral cortical areas. Paper-12432796. Synaptophysin in the human retina and retinoblastoma. An immunohistochemical and Western blotting study. Paper-6441766. Synaptophysin may act as an important calcium binding protein in the sensory transduction of hair cells. Paper-6159037. Determination of the base sequence of h-Sp-1 showed a size of 2170 bp and 43.4% homology with human synaptophysin. Paper-9926857. Synaptophysin was significantly lower in presenile than senile AD in right frontal and bilateral parietal lobes. Paper-9484345. Thus, rhabdomyosarcomas (0/5), lymphomas (0/4), or Ewing's sarcomas (0/2) were negative for synaptophysin. Paper-5785838. Ultrastructural distribution of synaptophysin and synaptic vesicle recycling at the frog neuromuscular junction. Paper-679263. Synaptophysin immunohistochemistry during vestibular hair cell recovery after gentamicin treatment. Paper-9868977. Glial cells were highlightened by antibodies to GFAP and neuronal cells by chromogranin and synaptophysin markers. Paper-12981951. We determined synaptophysin concentration from motor cortex in only 4 of our PSP cases, 2 demented and 2 non-demented. Paper-8969413. In normal liver and chronic hepatitis synaptophysin immunoreactivity was detected in the lobules and portal areas. Paper-8198380. Synaptophysin gene expression in schizophrenia. Investigation of synaptic pathology in the cerebral cortex. Paper-2186885. Changed intestinal distributions of SY-positive synaptic vesicles usually accompany colonic ganglion cell disorders. Paper-11075577. Cholinergic fibers were depleted to 15% of control values, while synaptophysin density was not significantly altered. Paper-7498577. Calcineurin and synaptophysin in the human spinal cord of normal individuals and patients with familial dysautonomia. Paper-6817412. Quantitative study of synaptophysin immunoreactivity of cerebral cortex and spinal cord in motor neuron disease. Paper-341364. Alpha and beta nicotinic acetylcholine receptors subunits and synaptophysin in putamen from Parkinson's disease. Paper-8514128. Severe panencephalic Pick's disease with Alzheimer's disease-like neuropil threads and synaptophysin immunoreactivity. Paper-7912359. We have studied the endocytic pathway in PC12 cells and localized synaptophysin to a subpopulation of early endosomes. Paper-7675961. These findings suggest that the major function of SNAT1 is not to replenish the transmitter pools of Glu and GABA. Paper-10287748. Synaptophysin immunohistochemistry reveals inside-out pattern of early synaptogenesis in ferret cerebral cortex. Paper-7695216. Synaptophysin identified in metastases of neuroendocrine tumors by immunocytochemistry and immunoblotting. Paper-5453289. Immunocytochemical labeling of undifferentiated PC12 cells reveals concentrations of synaptophysin in the perinuclear region. Paper-7639793. Dietary curcumin (2000 ppm), but not ibuprofen, suppressed oxidative damage (isoprostane levels) and synaptophysin loss. Paper-8918827. The origin of the Merkel cells (MC) being far from clear, this study was performed to establish if normal MC express SY. Paper-5830144. In temporal cortex (Brodmann area 21), synaptophysin mRNA was decreased in AD and non-AD dementia groups compared to controls. Paper-1414508. A clinicopathologic and immunohistochemical analysis of 53 cases of medulloblastoma with emphasis on synaptophysin expression. Paper-6537959. SYN expression was studied with a monoclonal antibody (MAb) by the immunoperoxidase technique in 53 medulloblastomas. Paper-6537959. There it plays a role in the process of membrane fusion during exocytosis by interacting with syntaxin and synaptophysin. Paper-11479760. In the gastrointestinal tract (except the antrum), chromogranin A is a better general neuroendocrine marker than synaptophysin. Paper-1778212. No reduction of EAATs or synaptophysin immunostaining was observed in demyelinated cortex in the absence of activated microglia. Paper-12500859. The synaptophysin immunoreactivity revealed connections between the terminals and the neurons of the deep cerebellar nuclei. Paper-1576582. We identify synaptophysin as a major specifically cholesterol-binding protein in PC12 cells and brain synaptic vesicles. Paper-2116869. One hundred ninety-four cases of EBD carcinomas were analyzed using immunohistochemistry with synaptophysin and chromogranin. Paper-11035394. Interestingly, synaptophysin was downregulated in these MRT cell lines in contrast with the neuroblastoma cell lines. Paper-9308658. Cholinergic fiber loss occurs in the absence of synaptophysin depletion in Alzheimer's disease primary visual cortex. Paper-7498577. This prenatal insult caused age-specific changes in accumbal dopamine levels and in synaptophysin expression in the frontal cortex. Paper-13071496. Overexpression of synaptophysin in MN9D cells can significantly increase the resistance of the transformants to MPP+ toxicity. Paper-10739107. Synaptophysin mRNA signal correlated negatively with the degree of dementia and negatively with the pathological severity of AD. Paper-1414508. Temporal cortex synaptophysin mRNA is reduced in Alzheimer's disease and is negatively correlated with the severity of dementia. Paper-1414508. Synaptophysin was found to be sulfated, which facilitated the determination of its exit route from the trans-Golgi network (TGN). Paper-6994861. Detection of synaptophysin-producing cells in human thymus by immunohistochemistry and nonradioactive in situ hybridization. Paper-1718188. Additionally, fifteen of sixteen neoplasms (93.8%) with MTSCC showed the expression of either chromogranin A or synaptophysin or both. Paper-11377794. These cytoplasmic structures were immunoreactive with antibodies against chromogranin A and synaptophysin in paraffin-embedded tissue. Paper-9358296. Synaptophysin immunoreactivity in Pick's disease: comparison with Alzheimer's disease and dementia with Lewy bodies. Paper-11617568. We conclude that SYN is a useful marker for medulloblastomas, indicating that this tumor is a primitive neuronal-neuroblastic neoplasm. Paper-6537959. The midbrain tumors showed weak reactivity to synaptophysin, and they blended with reactive astrocytes positive for glial markers. Paper-6927372. Further, SYN mRNA expression was studied by nonradioactive in situ hybridization using digoxigenin-labeled oligonucleotide probes. Paper-207776. Our data highlight synaptophysin as a sensitive and specific marker of both neuronal lineage and neoplastic character in gangliogliomas. Paper-6535869. Synaptophysin staining suggested that these peripheral nerve fibers in the inflammatory areas still contained synaptic vesicles. Paper-8246392. Reduction of synaptophysin immunoreactivity in the prefrontal cortex of subjects with schizophrenia. Regional and diagnostic specificity. Paper-1195314. In AD as compared to controls, a decrease in synaptophysin immunostaining was evident in the terminal zone of the perforant pathway. Paper-7493477. We present immunohistochemical data showing synaptophysin expression by cochlear hair cells in both late stage embryos and adult chickens. Paper-849087. Transplanted OB precursors gave rise to interneurons with dendritic spines in close proximity to synaptophysin-positive boutons. Paper-12268940. The interrelationships of synaptophysin, other presynaptic proteins, the cholinergic system, and severity of dementia in AD remain unclear. Paper-9075523. Synaptophysin expressed in the bronchopulmonary tract: neuroendocrine cells, neuroepithelial bodies, and neuroendocrine neoplasms. Paper-5622848. Dendritic spines and immunoreactivity of synaptophysin in the frontal cortex of humans with infantile brain damage. A correlative study. Paper-7963843. We investigated human thymic tissue by immunohistochemistry and in situ hybridization for the presence of synaptophysin-producing cells. Paper-1718188. The double labeling immunohistochemistry revealed that this granular structure overlaps synaptophysin-positive dystrophic neurites. Paper-10658919. Pan-endocrine markers chromogranin A and synaptophysin were positive in almost all carcinoid tumors, in 4 and 7 of the 10 NECs, respectively. Paper-10781039. Pheochromocytoma was diffusely positive for synaptophysin and chromogranin, whereas staining was focal and punctate in neuroblastoma. Paper-8017180. An immunohistological study with an antibody to synaptophysin showed that the number of synapses in transplanted ganglia was severely reduced. Paper-1682280. Immunohistochemical neuronal markers (neurofilament protein, synaptophysin and chromogranin) confirm the presence of a neuronal cell component. Paper-11528914. The latter structures displayed synaptophysin immunoreactivity, mostly localized to outer membranes of synaptic vesicles and dense bodies. Paper-7191853. As a marker for the synaptic vesicle-like organelles in this system, we have used the integral membrane glycoprotein p38 or synaptophysin. Paper-6610580. Newly synthesized synaptophysin is transported to synaptic-like microvesicles via constitutive secretory vesicles and the plasma membrane. Paper-6994861. The aim was to determine if dementia in Lewy body disease was associated with diminished concentrations of midfrontal cortex synaptophysin. Paper-1421314. However, in reactive retinas present in retinoblastoma eyes, synaptophysin was often observed in perikarya and processes of photoreceptors. Paper-6441766. In rats, entorhinal lesions resulted in diminished immunoreactivity for both synaptophysin and NT75 in the perforant pathway terminal zone. Paper-7493477. In parahippocampal gyrus, the loss of synaptophysin messenger RNA per neuron in schizophrenia was greater in deep than superficial laminae. Paper-400221. The predicted protein product derived from this clone is truncated, and the tissue distribution of HL-5 is different from that of synaptophysin. Paper-7236524. In CJD patients with a long clinical course, synaptophysin immunoreactivity decreased, and synaptic PrPCJD accumulated with a wider distribution. Paper-7213729. Positive SY immunostaining was solely restricted to the neural and sensory structures and did not include supporting cells of the organ of Corti. Paper-10194815. The synaptic-vesicle-specific proteins rab3a and synaptophysin are reduced in thalamus and related cortical brain regions in schizophrenic brains. Paper-2028121. Polariscopy, trichrome staining, and immunostaining for synaptophysin were very useful for differentiating spinal cord from peripheral nerve. Paper-8424457. MSCs treated with retinoic acid resulted in synaptic transmission, based on immunostaining of synaptophysin and electrophysiological studies. Paper-11284357. A transient increase in synaptophysin mRNA was observed after treatment with venlafaxine and fluoxetine whereas imipramine had no effect. Paper-12675206. Synaptophysin was expressed in all central neurocytomas and DNTs, in three oligodendrogliomas (43%), and in three oligoastrocytomas (75%). Paper-9266562. The superficial cellular layer was also diffusely stained for synaptophysin; there was a positive reaction in the linearly arranged myelin sheaths. Paper-6681968. In most cases, the studied oncocytomas did not react to synaptophysin showing different results from other adenomas of the anterior hypophysis. Paper-6079816. Quantitative analysis of synaptophysin immunoreactivity in human neocortex after cardiac arrest: confocal laser scanning microscopy study. Paper-1807907. Smooth muscle actin reactivity was more common in the benign tumors (p = 0.046) and synaptophysin reactivity in the malignant tumors (p = 0.010). Paper-8797010. Histologically, prominent neurocytic rosettes with synaptophysin expression were embedded in a glial tumor component resembling pilocytic astrocytoma. Paper-10047285. PGA/ chitosan grafts were evaluated as (+++) and (++), while PGA grafts were evaluated as (++) and (+) with use of synaptophysin antibody. Paper-13044091. Quantitative assessment of the synaptophysin immuno-reactivity of the cortical neuropil in various neurodegenerative disorders with dementia. Paper-7831472. Compared with synaptophysin, NB84 was more sensitive, although less specific, in the identification of neuroblastoma in formaldehyde-fixed tissue. Paper-1346475. Comparative immunohistochemical study on synaptophysin expression in the anterior horn of post-poliomyelitis and sporadic amyotrophic lateral sclerosis. Paper-898871. Some immunoreactivity for synaptophysin was also found in the secretory granules of the insulin-producing cells, although it was weaker in this location. Paper-6892470. Immunostaining of SYN in the cerebral cortex (an area not exhibiting spongiform lesions) was similar in viral infected and age-matched control mice. Paper-109659. Some adenohypophysial corticotrophs, most corticotrophs spreading to the posterior lobe, and Crooke's hyaline material did not immunoreact with anti- SYP. Paper-5829280. In contrast, synaptophysin was expressed in both the neonate and adult cochlea; immunoreactivity was found below IHCs around P4 and below OHCs at P5. Paper-831840. We have determined the structure and organization of the human synaptophysin gene and have established the chromosome localizations in man and mouse. Paper-16514. Synaptophysin immunoreactivity can be quantified by image analysis to evaluate loss of presynaptic terminals in human neurodegenerative diseases. Paper-341364. Central neurocytoma is a rare brain tumor composed of small round synaptophysin-positive cells, suggesting a neuronal origin of these tumor cells. Paper-641768. Synaptophysin, an integral membrane glycoprotein of presynaptic vesicles, was tested as an immuno-histochemical marker for childhood neuroblastoma. Paper-5785838. Morphometry of synaptophysin immunoreactive ganglion cells in Auerbach plexus in patients with colorectal cancer. Is this a new prognostic factor? Paper-10898271. Increased SYP immunoreactivity was accompanied with degeneration of neuronal cell bodies, their processes and terminals as well as glial cell proliferations. Paper-11307436. Localization of the glutamine transporter SNAT1 in rat cerebral cortex and neighboring structures, with a note on its localization in human cortex. Paper-10287748. Synaptophysin and syntaxin-1 are membrane proteins that associate with synaptic vesicles and presynaptic active zones at nerve endings, respectively. Paper-8997929. The membrane of these presumptive secretory microvesicles is known to contain synaptophysin, a major integral glycoprotein of neuronal synaptic vesicles. Paper-7809543. Axon varicosities positive for synaptophysin were present in the adventitia of ICA of young animals but were absent in the ligamentous cord of mature animals. Paper-12326758. Synaptophysin is an integral membrane protein of synaptic vesicles characterized by four transmembrane domains with both termini facing the cytoplasm. Paper-9185147. Immunohistochemical markers such as chromogranin A, synaptophysin, and serotonin have proven to be useful diagnostic tools in evaluating carcinoid tumors. Paper-6537945. Synaptophysin and/or chromogranin A may be expressed in epithelial cells of normal and dysplastic mammary gland and in some cancer of the breast. Paper-1010914. Immunoelectron microscopy showed synaptophysin expression in the extraskeletal myxoid chondrosarcoma but not in the skeletal chondrosarcoma case. Paper-9107659. Topology of innervation of labial salivary glands by protein gene product 9.5 and synaptophysin immunoreactive nerves in patients with Sjögren's syndrome. Paper-7505417. These processes are immunopositive for synaptophysin, and they terminate in two strata occupied by the dendrites of amacrine cells and ganglion cells. Paper-8300321. At the ultrastructural level, synaptophysin labeling is found on similar organelles in both undifferentiated and nerve growth factor-stimulated PC12 cells. Paper-7639793. One of the most prominent features of synaptophysin is that its cytoplasmic C-terminus largely consists of pentapeptide repeats initiated by a tyrosine residue. Paper-11182566. However, in some carcinoma cases ChgA and Syn were revealed in carcinoma cells, in myoepithelial cells, in some stromal mesenchymal cells and endothelial cells. Paper-1006686. Application of high pharmacological doses of estradiol promoted only synaptophysin expression, a presynaptic protein, but did not increase the number of boutons. Paper-11838690. Reduction of the small synaptic vesicle protein synaptophysin but not the large dense core chromogranins in the left thalamus of subjects with schizophrenia. Paper-2085113. The other is the essential role of membrane cholesterol, which specifically interacts with synaptophysin, the major transmembrane protein of synaptic vesicles. Paper-8550313. RESULTS: Prenatal exposure to ethanol did not alter levels of presynaptic proteins in the hippocampus or levels of synaptophysin in the prefrontal cortex. Paper-11511633. At day 60, immunohistochemistry revealed a 13.5% +/- 5.3% reduction in synaptophysin in the infralimbic cortex and cingulate gyrus in isolation-housed subjects. Paper-12682406. Two isoforms of the neural cell adhesion molecules were increased in the hippocampus of BD, whereas the synaptic protein marker, synaptophysin, was not changed. Paper-8511231. The dense ligamentous tissue proper was practically aneural, as was seen in staining for the generalized neuronal markers protein gene product 9.5 and synaptophysin. Paper-7373548. BACKGROUND: Decreased expression of proteins such as synaptophysin in the hippocampus and prefrontal cortex in schizophrenia is suggestive of synaptic pathology. Paper-2186885. Synaptophysin is an integral membrane glycoprotein (Mr 38,000) that occurs in presynaptic vesicles of neurons and in similar vesicles of the adrenal medulla. Paper-5246506. Synaptophysin (ICN, Costa Mesa, California) reactivity was strong in testicular tumor of the adrenogenital syndrome but rarely observed in Leydig cell tumor. Paper-12424689. By immunohistochemical staining for chromogranin A and synaptophysin, NE cell differentiation was detected in eight of 48 patients (16.7%) with PD adenocarcinoma. Paper-12138335. A series of nonneuroendocrine tumors, such as adenocarcinomas, sarcomas, lymphomas, and melanomas, were negative for both synaptophysin and NF proteins. Paper-5565102. Synaptophysin immunohistochemistry is an indirect labeling method with a high detection rate for intestinal ganglion cells by demonstrating their synapses. Paper-11075577. Quantitative immunohistochemistry of synaptophysin in human neocortex: an alternative method to estimate density of presynaptic terminals in paraffin sections. Paper-6815222. Dystrophic neurites were not detected by a modified Bielschowsky stain or by neurofilament, synaptophysin and tau immunohistochemistry in the olfactory mucosa. Paper-946995. We identified palpable tumor masses (log-rank test, P = 0.0027) and synaptophysin expression (log-rank test, P = 0.0422) as prognostic unfavorable markers for renal PNET. Paper-12082855. In the search for proteins regulating mu-opioid receptor (MOPr) endocytosis, synaptophysin was found to bind to the rat mu-opioid receptor in yeast two-hybrid assay. Paper-12381869. Immunohistochemical studies revealed variable immunoreactivity for simple epithelial cell cytokeratins and for synaptophysin (weak staining) in a minority of tumor cells. Paper-6874223. It was evenly distributed throughout the compartment at 14-22 weeks of gestation, and then from 23 weeks to the time of birth, there was a pericellular arrangement of SYN. Paper-9256850. Synaptophysin immuno-reactivity was found in all neuroblastomas (6/6), but not in the other small round-cell tumors to be considered in its differential diagnosis. Paper-5785838. Loss of synaptophysin-positive boutons on lumbar motor neurons innervating the medial gastrocnemius muscle of the SOD1G93A G1H transgenic mouse model of ALS. Paper-11291904. The other 21 cases of gangliogliomas were originally diagnosed as astrocytoma or mixed glioma, but were shown by synaptophysin staining to be gangliogliomas. Paper-7633103. Core biopsy of the mass and left axillary lymph node aspiration revealed neuroendocrine tumor of the breast, which stained positive for synaptophysin and chromogranin. Paper-12621731. As soon as cell migration had finished, the entire cortical plate contained dense synaptophysin immunoreactivity, in a pattern similar to that observed in the adult animal. Paper-7695216. The expression of synaptophysin in epithelial cells of the thymic cortex suggests that this protein may be involved in secretory activities related to T-cell maturation. Paper-1718188. Synaptophysin, a membrane glycoprotein of presynaptic vesicles, and neurofilament (NF) proteins were tested as immunohistochemical markers for neuroendocrine tumors. Paper-5565102. Vascular dementia in Spatz-Lindenberg's disease (SLD): cortical synaptophysin immunoreactivity as compared with dementia of Alzheimer type and non-demented controls. Paper-7873073. Loss of neurons would be expected to lead to the retrograde degeneration of their afferents, which should be reflected in a loss of presynaptic markers such as synaptophysin. Paper-10646095. In addition, no age-related change in number of synaptophysin-positive boutons was observed in the molecular layer of the dentate gyrus or CA1 region of hippocampus. Paper-1822300. Poorly differentiated endocrine carcinomas lack large dense core vesicles markers (chromogranin A), while widely express synaptophysin and cytosol endocrine markers. Paper-10238221. All other patients with small cell neuroendocrine carcinomas of the bladder and prostate demonstrated extremely high proliferation activity (>80%) and expressed Chr A and SNP. Paper-9553132. Pineal parenchymal tumor (PPT) differentiation was confirmed by immunohistochemical detection of neuroendocrine markers ( synaptophysin, neurofilaments, and chromogranin A). Paper-9666399. To assess the synaptic changes in the motor neurons, we examined immunoreactivities for synaptophysin in the spinal cord of 11 patients with Werdnig-Hoffmann disease. Paper-845343. For example, the reduction in synaptophysin messenger RNA in subicular neurons may be accompanied by decreased density of synaptic terminals in the nucleus accumbens. Paper-400221. Neuroendocrine differentiation of sparse cells interspersed in the pluristratified epithelium was documented by immunohistochemical staining for chromogranin and synaptophysin. Paper-9035346. This review will cover the evidence for tyrosine phosphorylation of synaptophysin and how this phosphorylation may control its function in the SV life cycle. Paper-11182566. Differentiation markers as an aid in the histological diagnosis of small-cell carcinoma of the lung: synopsis of intermediate filament protein and synaptophysin expression. Paper-5871757. This pattern resulted from binding of the antibodies to synaptic complexes of both rods and cones, shown by double-labelling with antibodies to either synaptophysin or actin. Paper-118728. This revealed the presence of 29 putative exons, organized into three genes, in addition to the 7 exons of the complete SYP coding region, all mapping within a 44-kb interval. Paper-1301901. The results show that fibrous SYN immunolabelling most probably indicating intra-axonal transport of synaptic vesicles can only be observed during the first half of gestation. Paper-2098786. Synaptophysin immunoreactivity of the cortical neuropil in vascular dementia of Binswanger type compared with the dementia of Alzheimer type and nondemented controls. Paper-8202230. Preliminary analysis of the latter suggested that this might reflect a high density of coding sequences and we therefore undertook the complete sequencing of a SYP-containing cosmid. Paper-1301901. Here, we tested whether intra-carotid infusion of bone marrow stromal cells promotes synaptophysin expression and neurological functional recovery after stroke in rats. Paper-12151988. The biogenesis of synaptic-like microvesicles (SLMVs) in neuroendocrine cells was investigated by studying the traffic of newly synthesized synaptophysin to SLMVs in PC12 cells. Paper-6994861. We conclude that the neuroendocrine marker SYN is expressed in a small subset of non-small-cell carcinomas of the cervix and its expression seems to correlate with a poor outcome. Paper-9320176. BACKGROUND: The prognostic significance of the presence of a neuroendocrine marker ( synaptophysin, SY) was analyzed in stage I of squamous carcinoma and adenocarcinoma of the lung. Paper-12519735. To understand the role of the synapsins and synaptophysin in the biology of a nerve cell means to elucidate the fundamental mechanism of brain function, the release of neurotransmitter. Paper-7591783. The innervation of human cerebral blood vessels has been examined using synaptophysin, a marker of synaptic vesicles, and chromogranin A, a marker of large dense-core vesicles. Paper-304151. Additionally, the distribution of the SV protein synaptophysin, when expressed by transfection in fibroblastic cells or in polarized epithelial cells (MDCK cells), was investigated. Paper-7816566. SNAT1 mediates glutamine (Gln) influx into neurons and is believed to replenish the transmitters pools of glutamate ( Glu) and gamma-aminobutyric acid ( GABA). Paper-10287748. Synaptophysin was consistently present in the tumor cells of pheochromocytomas (10/10), thyroid medullary carcinomas (8/8), and pancreatic islet cell tumors (6/6). Paper-5565102. Immunochemistry confirmed |