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A concatenated ERF-1 binding site probe identified a 30,000-Da protein. Paper-182197.
Low-level ERF-1 expression was detected in normal human mammary epithelial cells. Paper-182197.
Elevated expression levels of NCOA3, TOP1, and TFAP2C in breast tumors as predictors of poor prognosis. Paper-9837049.
TFAP2C controls hormone response in breast cancer cells through multiple pathways of estrogen signaling. Paper-12496553.
CITED2 interacted with the dimerization domain of TFAP2C, which is highly conserved in TFAP2A/B. Paper-9695909.
CONCLUSIONS: TOP1, TFAP2C, and (particularly) NCOA3 may be prognostic indicators for patients with breast tumors. Paper-9837049.
It is also demonstrated that HCN and ROS both activate similarly ERF1, a component of the ethylene signaling pathway. Paper-13749463.
These results indicate that ERF-1 expression represents a common mechanism of ER regulation in hormonally responsive carcinomas. Paper-182197.
Overexpression of TFAP2C in invasive breast cancer correlates with a poorer response to anti-hormone therapy and reduced patient survival. Paper-13495776.
Abundant ERF-1 expression was also found in endometrial carcinoma cell lines that express the ER-positive phenotype. Paper-182197.
This region contains two binding sites for a protein, estrogen receptor factor 1 ( ERF-1), which is expressed in ER-positive breast carcinomas. Paper-182197.
ERF-1 protein was purified from the ER-positive breast carcinoma cell line, MCF7, utilizing ion exchange and DNA affinity chromatography. Paper-997114.
We conclude that TFAP2C is a central control gene of hormone response and is a novel therapeutic target in the design of new drug treatments for breast cancer. Paper-12496553.
Reduced disease-free survival, but not reduced overall survival, was associated with high expression of TOP1 ( P = 0.035) and TFAP2C ( P = 0.035). Paper-9837049.
Knockdown of TFAP2C abrogated the mitogenic response to estrogen exposure and decreased hormone-responsive tumor growth of breast cancer xenografts. Paper-12496553.
Herein, we show that TFAP2C is the key regulator of hormone responsiveness in breast carcinoma cells through the control of multiple pathways of estrogen signaling. Paper-12496553.
PURPOSE: Transcription factor activator protein-2gamma ( TFAP2C, AP-2gamma) was reported previously in extraembryonic ectoderm and breast carcinomas but not in the testis. Paper-10621952.
Maturation of TFAP2A/ CK18+ epithelia and TFAP2G/ smooth muscle actin-positive myoepithelia proceeded in a distal-to-proximal manner beginning in the terminal end buds (week 22). Paper-12623763.
The ERF-1 transcription factor was previously shown to be involved in the regulation of estrogen receptor ( ER) gene transcription in hormonally responsive breast and endometrial carcinomas. Paper-997114.
CK5+ progenitor cells and CK5/ TFAP2A or CK5/ TFAP2G co-expressing intermediary glandular or myoepithelial cells were found in the terminal end buds of neonatal fetal breast tissue. Paper-12623763.
Given the central role of ER expression in breast carcinoma biology, ERF-1 is likely to regulate expression of a set of genes characteristic of the hormonally-responsive breast cancer phenotype. Paper-997114.
Aims: AP2alpha (TFAP2A) and AP2gamma ( TFAP2G) transcription factors have been implicated in the control of proliferation, differentiation and apoptosis of normal breast epithelium and in breast cancer. Paper-12623763.
It is proposed that the mode of action of cyanide in sunflower seed dormancy alleviation does not involve ethylene production and that ERF1 is a common component of the ethylene and cyanide signalling pathways. Paper-12815484.
In the present study, we report the complete sequence determination of the human TFAP2C gene encoding the AP-2gamma transcription factor plus the mapping of the transcription start site used in breast tumour-derived cells. Paper-9801687.
In particular we were able to identify potential hESC signature-like genes that encode transcription factors ( TFAP2C and MYCN), an RNA binding protein ( IMP-3), and a functionally uncharacterized protein ( MAGEA4). Paper-12057204.
The AP-2gamma transcription factor encoded by the TFAP2C gene is a member of a family of homologous DNA binding proteins that play essential roles during vertebrate embryogenesis but show a restricted pattern of expression in the adult. Paper-13495776.
Tcfap2b and Tcfap2c map to mouse chromosomes 1A2-4 and 2H3-4, respectively, while TFAP2B and TFAP2C map to human chromosomes 6p12 and 20q13.2, the latter being a region that is frequently amplified in breast carcinoma. Paper-643291.
Moreover, we found a significant association between T-ALL oncogenic subgroups and ectopic expression of a limited set of genes, including several developmental genes, namely HOXA, TLX1, TLX3, NKX3-1, SIX6, and TFAP2C. Paper-11066182.
Transcripts encoding Sertoli (KITL, FGF9, SOX9, FSHR, WT1) and germ (CKIT, TFAP2C) cell-specific products increased per testis through the second trimester, but expression per cell was static apart from TFAP2C, which declined. Paper-12631391.
Other genes that were highly ranked for their expression in ACC were those encoding the transcription factors SOX4 and AP-2 gamma, the latter of which also was overexpressed in ACC relative to 175 other carcinomas from 10 anatomical sites that we had previously profiled. Paper-9412289.
We applied recent knowledge from gonadal germ cell tumours and analysed expression of a wide panel of stem cell-related proteins (C-KIT, OCT-3/4 ( POU5F1), AP-2gamma ( TFAP2C), and NANOG) and developmentally regulated germ cell-specific proteins (including MAGE-A4, NY-ESO-1, and TSPY). Paper-11844673.
These synonyms are used for gene TFAP2C (transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)): Transcription factor ERF-1, Transcription factor AP-2 gamma, TFAP2G, hAP-2g, ERF1, AP2-GAMMA, AP2-gamma, Activating enhancer-binding protein 2 gamma.
These accession numbers are used for gene TFAP2C: Q9P1X2 (UNIPROT__AC), Q8IVB6 (UNIPROT__AC), CAC86997 (NCBI_GENBANK__AC), AAH35664 (NCBI_GENBANK__AC).
TFAP2C is a homologue of TFAP2C (transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)) from Bos taurus.
TFAP2C is a homologue of TFAP2C (transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)) from Pan troglodytes.
TFAP2C is a homologue of TFAP2C (transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)) from Gallus gallus.
TFAP2C is a homologue of TFAP2C (transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)) from Canis lupus familiaris.
TFAP2C is a homologue of Tcfap2c (transcription factor AP-2, gamma) from Mus musculus.
TFAP2C is a homologue of Tcfap2c (transcription factor AP-2, gamma) from Rattus norvegicus.
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