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No association of vacuolar protein sorting 26 polymorphisms with Alzheimer's disease. Paper-13197384.
The wild-type H beta 58 gene encodes a single 2.7 kb mRNA during embryonic and fetal development, and in many adult somatic tissues. Paper-7435725.
Genotyping of eight single nucleotide polymorphisms covering the complete VPS26 gene and haplotypic analysis revealed no association with AD. Paper-13197384.
A bioinformatic analysis of the mouse genome identified an additional transcribed paralog of the Vps26 retromer protein, which we termed Vps26B. Paper-11246536.
Identification and characterization of a novel, evolutionarily conserved gene disrupted by the murine H beta 58 embryonic lethal transgene insertion. Paper-7435725.
5. In this paper, we describe the characterization of a novel gene encoded at the H beta 58 locus, whose disruption appears to be responsible for the mutant phenotype. Paper-7435725.
The mammalian retromer complex consists of SNX1, SNX2, Vps26, Vps29 and Vps35, and retrieves lysosomal enzyme receptors from endosomes to the trans-Golgi network. Paper-12030559.
The core of retromer is composed of three subunits vacuolar protein sorting (Vps)35, Vps26 and Vps29, and in mammals, there are two paralogues of the medium subunit Vps26A and Vps26B. Paper-12726997.
We show here that clathrin and the retromer subunit Vps26 colocalize at the ultrastructural level on early/recycling endosomes containing Shiga toxin B-subunit, a well-studied retrograde transport cargo. Paper-13277613.
The loop is phylogenetically conserved and provides a mechanism for Vps26 integration into the complex that leaves the rest of the structure free for engagements with membranes and for conformational changes. Paper-12030559.
The mutant phenotype appears to be driven by hVps35 competing with endogenous yVps35, becoming incorporated into defective retromer complexes and causing proteasomal degradation of endogenous Vps26 and Vps29. Paper-12601884.
Hydrophobic residues and a glycine in this loop are required for integration into the retromer complex and endosomal localization of human Vps26, and for the function of yeast Vps26 in carboxypeptidase Y sorting. Paper-12030559.
The association of Vps26- Vps29- Vps35 with endosomes requires the presence of either SNX1 or SNX2, whereas SNX1/2 can be recruited to endosomes independently of Vps26- Vps29- Vps35. Paper-12430425.
The recognition of cargo proteins by the retromer is performed by the Vps35p/ VPS35 (where Vps is vacuolar protein sorting) component, which together with Vps26p/ VPS26 and Vps29p/ VPS29, forms the cargo-selective subcomplex. Paper-12541666.
The SNX subunits contain PX and BAR domains that allow binding to PI(3)P enriched, highly curved membranes of endosomal vesicles and tubules, while Vps26, Vps29 and Vps35 have arrestin, phosphoesterase and alpha-solenoid folds, respectively. Paper-12935874.
A hybrid structural model derived from crystal structures, electron microscopy, interaction studies and bioinformatics shows that the alpha-solenoid fold extends the full length of VPS35, and that VPS26 is bound at the opposite end from VPS29. Paper-12531877.
Vps26 proteins have a striking similarity to the arrestin family of proteins that regulate the signalling and endocytosis of G-protein-coupled receptors, although we observe that surface residues involved in arrestin function are not conserved in Vps26. Paper-12726997.
These observations indicate that the mammalian retromer complex assembles by sequential association of SNX1/2 and Vps26- Vps29- Vps35 subcomplexes on endosomal membranes and that SNX1 and SNX2 play interchangeable but essential roles in retromer structure and function. Paper-12430425.
The open reading frame shows significant homology to Hbeta58, a mouse gene essential for embryogenesis, PEP8, a yeast homologue of Hbeta58, and an expressed sequence tag of Arabidopsis thariana, suggesting that DCRA has some important function that has been conserved during the course of evolution. Paper-1304730.
These synonyms are used for gene VPS26A (vacuolar protein sorting 26 homolog A (S. pombe)): VPS26, Vesicle protein sorting 26A, Vesicle protein sorting 26, Vacuolar protein sorting-associated protein 26A, vacuolar protein sorting 26 homolog A (yeast), Vacuolar protein sorting 26, PEP8A, hVPS26, Hbeta58, HB58, FLJ12930.
These accession numbers are used for gene VPS26A: B2RDD3 (UNIPROT__AC), A8K3C1 (UNIPROT__AC).
VPS26A is a homologue of VPS26A (vacuolar protein sorting 26 homolog A (S. pombe)) from Canis familiaris.
VPS26A is a homologue of VPS26A (vacuolar protein sorting 26 homolog A (S. pombe)) from Bos taurus.
VPS26A is a homologue of VPS26A (vacuolar protein sorting 26 homolog A (S. pombe)) from Gallus gallus.
VPS26A is a homologue of VPS26A (vacuolar protein sorting 26 homolog A (S. pombe)) from Pan troglodytes.
VPS26A is a homologue of Vps26a (vacuolar protein sorting 26 homolog A (yeast)) from Mus musculus.
VPS26A is a homologue of Vps26a (vacuolar protein sorting 26 homolog A (yeast)) from Rattus norvegicus.
VPS26A is a homologue of vps26a (vacuolar protein sorting 26 homolog A (yeast)) from Danio rerio.
VPS26A is a homologue of PFL2415w (Hbeta58/Vps26 protein homolog, putative) from Plasmodium falciparum 3D7.
VPS26A is a homologue of Os11g0629200 (Os11g0629200) from Oryza sativa (japonica cultivar-group).
VPS26A is a homologue of AT5G53530 (vacuolar protein sorting-associated protein 26, putative / VPS26, putative) from Arabidopsis thaliana.
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