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Hereditary joint disorder in progressive ankylosis ( ank/ ank) mice. II. Effect of high-dose hydrocortisone treatment on inflammation and intraarticular calcium hydroxyapatite deposits. Paper-5331608. No changes, however, occurred in the joint morphology of hydrocortisone-treated normal ( ank/+) mice. Paper-5331608.
Mice homozygous for the progressive ankylosis trait develop an inflammatory joint disorder associated with the intraarticular deposition of calcium hydroxyapatite. Paper-5331608.
Since inhibition of inflammation by hydrocortisone treatment did not block apatite accumulation, intraarticular deposition of hydroxyapatite occurs independent of inflammation in progressive ankylosis. Paper-5331608.
When affected ( ank/ ank) mice were treated with high doses of hydrocortisone, synovitis receded, development of cartilaginous and bony osteophytes halted, and calcium hydroxyapatite accumulated in and distended the synovial spaces. Paper-5331608.
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iHOP - Information Hyperlinked over Proteins .
Concept & Implementation by Robert Hoffmann.