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Genetic marker study of dentinogenesis imperfecta.Pairwise linkage analysis was performed using the procedures of Morton.
Tight linkage between DGI-II and eleven genetic markers, including Gc and EGF, was excluded.
Gc and MNS blood group antigen typing were done using commercial SERA. Paper-68231.
Results from this study demonstrated that DGI-II may possibly arise from more than one genetic mutation.
The tightest linkage with DGI-II was identified with the probe INP10 at theta = 0.0 with lod = +3.91. Paper-68231.
DGI-II has been linked to the group specific component (Gc) on 4q and to interferon induced protein 10 ( INP10) on 4q. Paper-68231.
Restriction fragment length polymorphism analysis using Southern blotting was done on the remaining markers.
However, INP10 RFLP differences were detected between the families, such that DGI-II correlated with different alleles in each family. Paper-68231.
Affected family members had brownish discoloration of the teeth, enamel fracturing and radiographic evidence of coronal and radicular pulp chamber obliteration. Paper-68231.
Thirteen polymorphic markers on 4q were studied including D4S35, D4S1, ALB, Gc, MGSA, AR, INP10, ADH3, FGFB, EGF, IL2, IF, and MNS. Paper-68231.
We studied a three generation family with DGI-II along with a four generation DGI-II family to more precisely place DGI-II in the existing genetic map of 4q and to determine if genetic heterogeneity existed between various DGI-II families.
Important links !
iHOP - Information Hyperlinked over Proteins .
Concept & Implementation by Robert Hoffmann.