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The enhancer of split complex of Drosophila includes four Notch-regulated members of the bearded gene family. Paper-8425356. Consistent with this, both are expressed specifically in multiple settings where N signaling takes place.
In this report, we analyze the structure, regulation and activity of the m1, m2 and m6 genes of the E(spl)-C. Paper-8425356.
We show that overexpression of either m2 or m6 interferes with N-dependent cell fate decisions in adult PNS development. Paper-8425356.
Surprisingly, while misexpression of m6 impairs lateral inhibition, overexpression of m2 potentiates it, suggesting functional diversification within the Brd protein family. Paper-8425356.
During Drosophila development, transcriptional activation of genes of the Enhancer of split Complex (E(spl)-C) is a major response to cell-cell signaling via the Notch (N) receptor. Paper-8425356.
Finally, we present our initial studies of the structure, expression and regulation of the newest member of the Brd gene family, Ocho, which is located in the recently identified Bearded Complex. Paper-8425356.
Particularly noteworthy is our finding that m6 transcripts accumulate both in adult muscle founder cells in the embryo and in a subset of adepithelial (muscle precursor) cells associated with the wing imaginal disc. Paper-8425356.
We demonstrate that the expression of both m2 and m6 is responsive to N receptor activity and that both genes are apparently direct targets of regulation by the N- activated transcription factor Suppressor of Hairless. Paper-8425356.
We find that E(spl)m2 and E(spl)m6 encode divergent members of the Bearded ( Brd) family of proteins, bringing to four (m(alpha), m2, m4 and m6) the number of Brd family genes in the E(spl)-C. Paper-8425356.
Although the structure and function of the E(spl)-C have been studied intensively during the past decade, these efforts have focused heavily on seven transcription units that encode basic helix-loop-helix (bHLH) repressors; the non-bHLH members of the complex have received comparatively little attention.
Important links !
iHOP - Information Hyperlinked over Proteins .
Concept & Implementation by Robert Hoffmann.