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Thyroid hormone-induced expression of specific somatostatin receptor subtypes correlates with involution of the TtT-97 murine thyrotrope tumor. Paper-862074. This study investigates the regulation of somatostatin receptor subtypes in this tumor. Paper-862074.
T4 administration resulted in a reduction in TSH beta mRNA expression and a marked degree of tumor involution. Paper-862074.
The TtT-97 tumor is an in vivo murine thyrotropic model that has retained its physiological response to thyroid hormone. Paper-862074.
Moreover, analogs of native somatostatin have potent TSH-reducing and growth-retarding effects on human thyrotropinomas. Paper-862074.
Somatostatin is a hypothalamic peptide that has been implicated in the negative regulation of TSH secretion in the thyrotrope. Paper-862074.
Following the protracted hypothyroid state, treatment with thyroid hormone will induce a decline in TSH and reduce thyrotrope hyperplasia. Paper-862074.
TtT-97 tumors, actively growing in hypothyroid mice, did not express any significant somatostatin receptor messenger RNA (mRNA) or protein. Paper-862074.
Thus, the TtT-97 tumor provides a thyrotrope-specific model in which to study the regulation of somatostatin receptor subtypes by thyroid hormone and correlate this expression with both antisecretory and antiproliferative effects. Paper-862074.
Analysis of residual tumors from thyroid hormone-treated mice showed the specific up-regulation of SSTR1 and SSTR5 mRNA subtypes and the appearance of abundant, high affinity SSTR receptor-binding sites within the tumor. Paper-862074.
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